Supplemental Table 11. Sensitivity analyses of the associations of social isolation and loneliness with the risk of VTE. Note: VTE, venous thromboembolism; CVD, cardiovascular disease; HR, hazard ratio; CI, confidence interval. Ref, reference group.

group

least_isolated

moderately_isolated

most_isolated

loneliness_no

loneliness_yes

Excluding VTE diagnosed within 2 years after baseline

2503/2266290

2299/1943172

918/644390

3862/3095611

1540/1541000

Ref

1.24 (1.15-1.34)

1.30 (1.21-1.40)

1.00 (Ref)

1.15 (1.03-1.29)

Excluding individuals with CVD and cancer

1250/1313195

1241/1311537

520/426667

2390/1054537

728/521930

Ref

0.98 (0.91-1.05)

1.25 (1.16-1.35)

1.08 (1.01-1.15)

1.20 (1.03-1.41)

Restricting to individuals with completing covariates

2167/1860253

1273/1811754

781/15478

3456/2643211

1183/1131898

Ref

1.06 (1.00-1.13)

1.28 (1.18-1.39)

1.05 (0.99-1.11)

1.10 (0.97-1.25)