Associations of the Biological Age Accelerations With the Risk of VHD
Biological Age	Cases/Person-Years	Incidence Rate (95% CI), per 1,000 Person-Years	HR (95% CI)	P Value	PAF (95% CI), %
KDM-BA acceleration, continuous	8,146/4,512,447.4	1.81 (0.77-1.84)	1.35 (1.32-1.38)	<0.001	NA
Q1	1,445/1,142,018.4	1.27 (0.20-1.33)	Reference	<0.001	8.17
Q2	1,702/1,136,599.6	1.50 (1.43-1.57)	1.13 (1.05-1.21)	<0.001	17.03
Q3	2,038/1,129,286.9	1.80 (1.73-1.88)	1.31 (1.22-1.40)	<0.001	34.41
Q4	2,961/1,104,542.5	2.68 (2.59-2.78)	1.86 (1.74-1.99)	<0.001	NA
PhenoAge acceleration, continuous	8,146/4,512,447.4	1.81 (0.77-1.84)	1.29 (1.26-1.32)	<0.001	NA
Q1	1,524/1,146,118.2	1.33 (1.26-1.40)	Reference	0.090	4.96
Q2	1,683/1,141,056.3	1.47 (1.41-1.55)	1.06 (0.99-1.14)	<0.001	11.81
Q3	1,932/1,131,566.5	1.71 (1.63-1.79)	1.15 (1.08-1.24)	<0.001	32.73
Q4	3,007/1,093,706.4	2.75 (2.65-2.85)	1.67 (1.57-1.79)	<0.001	NA