Subgroup Analysis Results
Stratified by Covariates and Outcomes
Outcome	Subgroup	Interaction Group	HR (95% CI)	P-value
Male
CVD Death	sex	Low AIP/Low GFR	2.76 (2.26-3.37)	<0.001
CVD Death	sex	High AIP/Low GFR	1.65 (1.31-2.08)	<0.001
CVD Death	sex	High AIP/High GFR	0.84 (0.73-0.96)	0.012
CVD Death	sex	Overall P-value		<0.001
All-cause Death	sex	Low AIP/Low GFR	2.00 (1.74-2.30)	<0.001
All-cause Death	sex	High AIP/Low GFR	1.41 (1.21-1.63)	<0.001
All-cause Death	sex	High AIP/High GFR	0.82 (0.76-0.89)	<0.001
All-cause Death	sex	Overall P-value		<0.001
Female
CVD Death	sex	Low AIP/Low GFR	2.35 (1.91-2.90)	<0.001
CVD Death	sex	High AIP/Low GFR	2.08 (1.71-2.53)	<0.001
CVD Death	sex	High AIP/High GFR	0.85 (0.74-0.97)	0.017
CVD Death	sex	Overall P-value		<0.001
All-cause Death	sex	Low AIP/Low GFR	1.96 (1.69-2.27)	<0.001
All-cause Death	sex	High AIP/Low GFR	1.90 (1.66-2.16)	<0.001
All-cause Death	sex	High AIP/High GFR	0.85 (0.78-0.93)	<0.001
All-cause Death	sex	Overall P-value		<0.001
65-85
CVD Death	age_group	Low AIP/Low GFR	2.49 (2.13-2.91)	<0.001
CVD Death	age_group	High AIP/Low GFR	1.86 (1.59-2.17)	<0.001
CVD Death	age_group	High AIP/High GFR	0.84 (0.76-0.93)	<0.001
CVD Death	age_group	Overall P-value		<0.001
All-cause Death	age_group	Low AIP/Low GFR	1.90 (1.71-2.12)	<0.001
All-cause Death	age_group	High AIP/Low GFR	1.60 (1.44-1.77)	<0.001
All-cause Death	age_group	High AIP/High GFR	0.82 (0.77-0.87)	<0.001
All-cause Death	age_group	Overall P-value		<0.001
>85
CVD Death	age_group	Low AIP/Low GFR	1.70 (1.11-2.58)	0.014
CVD Death	age_group	High AIP/Low GFR	1.20 (0.76-1.90)	0.436
CVD Death	age_group	High AIP/High GFR	0.95 (0.68-1.32)	0.748
CVD Death	age_group	Overall P-value		0.076
All-cause Death	age_group	Low AIP/Low GFR	1.51 (1.11-2.04)	0.008
All-cause Death	age_group	High AIP/Low GFR	1.14 (0.82-1.57)	0.440
All-cause Death	age_group	High AIP/High GFR	1.12 (0.90-1.40)	0.307
All-cause Death	age_group	Overall P-value		0.085
No
CVD Death	htn	Low AIP/Low GFR	3.08 (2.11-4.50)	<0.001
CVD Death	htn	High AIP/Low GFR	1.97 (1.26-3.07)	0.003
CVD Death	htn	High AIP/High GFR	0.77 (0.60-0.99)	0.044
CVD Death	htn	Overall P-value		<0.001
CVD Death	marital	Low AIP/Low GFR	1.98 (1.60-2.46)	<0.001
CVD Death	marital	High AIP/Low GFR	1.53 (1.22-1.93)	<0.001
CVD Death	marital	High AIP/High GFR	0.81 (0.69-0.95)	0.010
CVD Death	marital	Overall P-value		<0.001
CVD Death	smoke	Low AIP/Low GFR	2.56 (2.20-2.99)	<0.001
CVD Death	smoke	High AIP/Low GFR	1.83 (1.56-2.14)	<0.001
CVD Death	smoke	High AIP/High GFR	0.83 (0.75-0.92)	<0.001
CVD Death	smoke	Overall P-value		<0.001
CVD Death	edu	Low AIP/Low GFR	2.35 (2.02-2.75)	<0.001
CVD Death	edu	High AIP/Low GFR	1.82 (1.56-2.14)	<0.001
CVD Death	edu	High AIP/High GFR	0.82 (0.73-0.91)	<0.001
CVD Death	edu	Overall P-value		<0.001
All-cause Death	htn	Low AIP/Low GFR	1.91 (1.50-2.44)	<0.001
All-cause Death	htn	High AIP/Low GFR	1.88 (1.48-2.39)	<0.001
All-cause Death	htn	High AIP/High GFR	0.74 (0.65-0.84)	<0.001
All-cause Death	htn	Overall P-value		<0.001
All-cause Death	marital	Low AIP/Low GFR	1.66 (1.42-1.94)	<0.001
All-cause Death	marital	High AIP/Low GFR	1.51 (1.28-1.77)	<0.001
All-cause Death	marital	High AIP/High GFR	0.81 (0.73-0.90)	<0.001
All-cause Death	marital	Overall P-value		<0.001
All-cause Death	smoke	Low AIP/Low GFR	1.91 (1.71-2.13)	<0.001
All-cause Death	smoke	High AIP/Low GFR	1.62 (1.46-1.80)	<0.001
All-cause Death	smoke	High AIP/High GFR	0.82 (0.77-0.87)	<0.001
All-cause Death	smoke	Overall P-value		<0.001
All-cause Death	edu	Low AIP/Low GFR	1.83 (1.64-2.04)	<0.001
All-cause Death	edu	High AIP/Low GFR	1.61 (1.44-1.79)	<0.001
All-cause Death	edu	High AIP/High GFR	0.79 (0.73-0.84)	<0.001
All-cause Death	edu	Overall P-value		<0.001
Yes
CVD Death	htn	Low AIP/Low GFR	2.33 (1.99-2.73)	<0.001
CVD Death	htn	High AIP/Low GFR	1.72 (1.47-2.02)	<0.001
CVD Death	htn	High AIP/High GFR	0.82 (0.74-0.91)	<0.001
CVD Death	htn	Overall P-value		<0.001
CVD Death	marital	Low AIP/Low GFR	2.63 (2.16-3.19)	<0.001
CVD Death	marital	High AIP/Low GFR	1.96 (1.61-2.38)	<0.001
CVD Death	marital	High AIP/High GFR	0.87 (0.77-0.99)	0.030
CVD Death	marital	Overall P-value		<0.001
CVD Death	smoke	Low AIP/Low GFR	2.31 (1.51-3.53)	<0.001
CVD Death	smoke	High AIP/Low GFR	2.14 (1.39-3.30)	<0.001
CVD Death	smoke	High AIP/High GFR	0.82 (0.62-1.06)	0.134
CVD Death	smoke	Overall P-value		<0.001
CVD Death	edu	Low AIP/Low GFR	2.84 (1.86-4.34)	<0.001
CVD Death	edu	High AIP/Low GFR	1.53 (0.98-2.39)	0.062
CVD Death	edu	High AIP/High GFR	0.90 (0.71-1.13)	0.363
CVD Death	edu	Overall P-value		<0.001
All-cause Death	htn	Low AIP/Low GFR	1.93 (1.73-2.16)	<0.001
All-cause Death	htn	High AIP/Low GFR	1.54 (1.38-1.71)	<0.001
All-cause Death	htn	High AIP/High GFR	0.83 (0.78-0.89)	<0.001
All-cause Death	htn	Overall P-value		<0.001
All-cause Death	marital	Low AIP/Low GFR	1.96 (1.72-2.24)	<0.001
All-cause Death	marital	High AIP/Low GFR	1.59 (1.40-1.80)	<0.001
All-cause Death	marital	High AIP/High GFR	0.84 (0.78-0.90)	<0.001
All-cause Death	marital	Overall P-value		<0.001
All-cause Death	smoke	Low AIP/Low GFR	2.27 (1.74-2.95)	<0.001
All-cause Death	smoke	High AIP/Low GFR	1.55 (1.15-2.09)	0.004
All-cause Death	smoke	High AIP/High GFR	0.81 (0.69-0.95)	0.009
All-cause Death	smoke	Overall P-value		<0.001
All-cause Death	edu	Low AIP/Low GFR	2.31 (1.77-3.01)	<0.001
All-cause Death	edu	High AIP/Low GFR	1.37 (1.05-1.79)	0.019
All-cause Death	edu	High AIP/High GFR	0.94 (0.83-1.07)	0.368
All-cause Death	edu	Overall P-value		<0.001