Descriptive statistics by MS

Table showing summary statistics for the entire sample and by migration status, with sex sub-stratification. Country of birth and country of citizenship were included as dichotomic variables. Categorical variables are expressed as counts (%). Normally distributed continuous variables (age) are expressed as mean (SD), and non-normally distributed continuous variables (preoperative length of stay, surgery duration and HDI for both country of birth and country of citizenship) are expressed as median (Q1 - Q3). Outcome-related variables are not included (SSI, SSI type and follow-up time).

Total (Both)

Total by Sex

Migrants (Both)

Migrants by Sex

Non-migrants (Both)

Non-migrants by Sex

Variable

N = 5,7991

Male
N = 3,0561

Female
N = 2,7431

N = 4901

Male
N = 2541

Female
N = 2361

N = 5,3091

Male
N = 2,8021

Female
N = 2,5071

Age

Min - Max

16 - 95.0

18 - 95.0

16 - 95.0

20 - 94.0

21 - 94.0

20 - 85.0

16 - 95.0

18 - 95.0

16 - 95.0

Mean (SD)

66 (12.5)

65 (12.2)

68 (12.6)

59 (13.3)

58 (12.6)

60 (14.1)

67 (12.2)

66 (12.0)

68 (12.2)

Sex

Male

3,056 (52.7%)

254 (51.8%)

2,802 (52.8%)

Female

2,743 (47.3%)

236 (48.2%)

2,507 (47.2%)

Year of surgery

2007

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

2008

95 (1.6%)

50 (1.6%)

45 (1.6%)

2 (0.4%)

1 (0.4%)

1 (0.4%)

93 (1.8%)

49 (1.7%)

44 (1.8%)

2009

245 (4.2%)

111 (3.6%)

134 (4.9%)

8 (1.6%)

5 (2.0%)

3 (1.3%)

237 (4.5%)

106 (3.8%)

131 (5.2%)

2010

290 (5.0%)

138 (4.5%)

152 (5.5%)

14 (2.9%)

6 (2.4%)

8 (3.4%)

276 (5.2%)

132 (4.7%)

144 (5.7%)

2011

348 (6.0%)

180 (5.9%)

168 (6.1%)

14 (2.9%)

7 (2.8%)

7 (3.0%)

334 (6.3%)

173 (6.2%)

161 (6.4%)

2012

369 (6.4%)

185 (6.1%)

184 (6.7%)

29 (5.9%)

10 (3.9%)

19 (8.1%)

340 (6.4%)

175 (6.2%)

165 (6.6%)

2013

379 (6.5%)

197 (6.4%)

182 (6.6%)

23 (4.7%)

12 (4.7%)

11 (4.7%)

356 (6.7%)

185 (6.6%)

171 (6.8%)

2014

295 (5.1%)

138 (4.5%)

157 (5.7%)

11 (2.2%)

9 (3.5%)

2 (0.8%)

284 (5.3%)

129 (4.6%)

155 (6.2%)

2015

208 (3.6%)

103 (3.4%)

105 (3.8%)

15 (3.1%)

6 (2.4%)

9 (3.8%)

193 (3.6%)

97 (3.5%)

96 (3.8%)

2016

297 (5.1%)

128 (4.2%)

169 (6.2%)

20 (4.1%)

10 (3.9%)

10 (4.2%)

277 (5.2%)

118 (4.2%)

159 (6.3%)

2017

298 (5.1%)

133 (4.4%)

165 (6.0%)

19 (3.9%)

6 (2.4%)

13 (5.5%)

279 (5.3%)

127 (4.5%)

152 (6.1%)

2018

160 (2.8%)

93 (3.0%)

67 (2.4%)

8 (1.6%)

6 (2.4%)

2 (0.8%)

152 (2.9%)

87 (3.1%)

65 (2.6%)

2019

395 (6.8%)

179 (5.9%)

216 (7.9%)

30 (6.1%)

11 (4.3%)

19 (8.1%)

365 (6.9%)

168 (6.0%)

197 (7.9%)

2020

361 (6.2%)

181 (5.9%)

180 (6.6%)

21 (4.3%)

9 (3.5%)

12 (5.1%)

340 (6.4%)

172 (6.1%)

168 (6.7%)

2021

283 (4.9%)

140 (4.6%)

143 (5.2%)

27 (5.5%)

10 (3.9%)

17 (7.2%)

256 (4.8%)

130 (4.6%)

126 (5.0%)

2022

175 (3.0%)

98 (3.2%)

77 (2.8%)

20 (4.1%)

10 (3.9%)

10 (4.2%)

155 (2.9%)

88 (3.1%)

67 (2.7%)

2023

829 (14.3%)

520 (17.0%)

309 (11.3%)

108 (22.0%)

60 (23.6%)

48 (20.3%)

721 (13.6%)

460 (16.4%)

261 (10.4%)

2024

772 (13.3%)

482 (15.8%)

290 (10.6%)

121 (24.7%)

76 (29.9%)

45 (19.1%)

651 (12.3%)

406 (14.5%)

245 (9.8%)

Surgical procedure (study classification)

THA

1,191 (20.5%)

604 (19.8%)

587 (21.4%)

101 (20.6%)

43 (16.9%)

58 (24.6%)

1,090 (20.5%)

561 (20.0%)

529 (21.1%)

TKA

1,305 (22.5%)

406 (13.3%)

899 (32.8%)

83 (16.9%)

26 (10.2%)

57 (24.2%)

1,222 (23.0%)

380 (13.6%)

842 (33.6%)

Valve replacement

329 (5.7%)

182 (6.0%)

147 (5.4%)

37 (7.6%)

18 (7.1%)

19 (8.1%)

292 (5.5%)

164 (5.9%)

128 (5.1%)

CABG + valve

74 (1.3%)

53 (1.7%)

21 (0.8%)

3 (0.6%)

2 (0.8%)

1 (0.4%)

71 (1.3%)

51 (1.8%)

20 (0.8%)

Colon or rectal resection

2,069 (35.7%)

1,118 (36.6%)

951 (34.7%)

158 (32.2%)

81 (31.9%)

77 (32.6%)

1,911 (36.0%)

1,037 (37.0%)

874 (34.9%)

CABG

831 (14.3%)

693 (22.7%)

138 (5.0%)

108 (22.0%)

84 (33.1%)

24 (10.2%)

723 (13.6%)

609 (21.7%)

114 (4.5%)

Preoperative length of stay (days)

Min - Max

0 - 59.0

0 - 59.0

0 - 51.0

0 - 26.0

0 - 20.0

0 - 26.0

0 - 59.0

0 - 59.0

0 - 51.0

Median (Q1 - Q3)

1 (0.0 - 1)

1 (0.0 - 1)

1 (0.0 - 1)

1 (0.0 - 1)

1 (0.0 - 1)

1 (0.0 - 1)

1 (0.0 - 1)

1 (0.0 - 1)

1 (0.0 - 1)

ASA classification

I

455 (7.8%)

200 (6.5%)

255 (9.3%)

48 (9.8%)

16 (6.3%)

32 (13.6%)

407 (7.7%)

184 (6.6%)

223 (8.9%)

II

3,211 (55.4%)

1,447 (47.3%)

1,764 (64.3%)

252 (51.4%)

112 (44.1%)

140 (59.3%)

2,959 (55.7%)

1,335 (47.6%)

1,624 (64.8%)

III

1,557 (26.8%)

961 (31.4%)

596 (21.7%)

111 (22.7%)

67 (26.4%)

44 (18.6%)

1,446 (27.2%)

894 (31.9%)

552 (22.0%)

IV

572 (9.9%)

444 (14.5%)

128 (4.7%)

79 (16.1%)

59 (23.2%)

20 (8.5%)

493 (9.3%)

385 (13.7%)

108 (4.3%)

V

4 (0.1%)

4 (0.1%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

4 (0.1%)

4 (0.1%)

0 (0.0%)

Degree of urgency

Elective

5,675 (97.9%)

2,975 (97.3%)

2,700 (98.4%)

474 (96.7%)

245 (96.5%)

229 (97.0%)

5,201 (98.0%)

2,730 (97.4%)

2,471 (98.6%)

Urgent

6 (0.1%)

1 (0.0%)

5 (0.2%)

2 (0.4%)

1 (0.4%)

1 (0.4%)

4 (0.1%)

0 (0.0%)

4 (0.2%)

Semi-elective

118 (2.0%)

80 (2.6%)

38 (1.4%)

14 (2.9%)

8 (3.1%)

6 (2.5%)

104 (2.0%)

72 (2.6%)

32 (1.3%)

Wound class

Clean

3,733 (64.4%)

1,937 (63.4%)

1,796 (65.5%)

333 (68.0%)

174 (68.5%)

159 (67.4%)

3,400 (64.0%)

1,763 (62.9%)

1,637 (65.3%)

Clean-contaminated

1,744 (30.1%)

949 (31.1%)

795 (29.0%)

138 (28.2%)

72 (28.3%)

66 (28.0%)

1,606 (30.3%)

877 (31.3%)

729 (29.1%)

Contaminated

317 (5.5%)

165 (5.4%)

152 (5.5%)

19 (3.9%)

8 (3.1%)

11 (4.7%)

298 (5.6%)

157 (5.6%)

141 (5.6%)

Infected

5 (0.1%)

5 (0.2%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

5 (0.1%)

5 (0.2%)

0 (0.0%)

Antibiotic prophylaxis

Adequate

5,433 (93.7%)

2,843 (93.0%)

2,590 (94.4%)

439 (89.6%)

230 (90.6%)

209 (88.6%)

4,994 (94.1%)

2,613 (93.3%)

2,381 (95.0%)

Inadequate

366 (6.3%)

213 (7.0%)

153 (5.6%)

51 (10.4%)

24 (9.4%)

27 (11.4%)

315 (5.9%)

189 (6.7%)

126 (5.0%)

Minimally invasive surgery

1,827 (31.5%)

983 (32.2%)

844 (30.8%)

142 (29.0%)

69 (27.2%)

73 (30.9%)

1,685 (31.7%)

914 (32.6%)

771 (30.8%)

Surgery duration (minutes)

Min - Max

4 - 1,685.0

4 - 689.0

10 - 1,685.0

22 - 531.0

35 - 460.0

22 - 531.0

4 - 1,685.0

4 - 689.0

10 - 1,685.0

Median (Q1 - Q3)

120 (90.0 - 186)

140 (99.0 - 218)

105 (83.0 - 150)

135 (99.0 - 215)

155 (110.0 - 246)

120 (90.0 - 181)

120 (90.0 - 183)

140 (98.0 - 215)

105 (81.0 - 147)

Country of birth (Dicotomic)

Non-Spain

487 (8.4%)

253 (8.3%)

234 (8.5%)

487 (99.4%)

253 (99.6%)

234 (99.2%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Spain

5,312 (91.6%)

2,803 (91.7%)

2,509 (91.5%)

3 (0.6%)

1 (0.4%)

2 (0.8%)

5,309 (100.0%)

2,802 (100.0%)

2,507 (100.0%)

Country of birth - World Region

East Asia & Pacific

28 (0.5%)

15 (0.5%)

13 (0.5%)

28 (5.7%)

15 (5.9%)

13 (5.5%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Europe & Central Asia

5,432 (93.7%)

2,869 (93.9%)

2,563 (93.4%)

123 (25.1%)

67 (26.4%)

56 (23.7%)

5,309 (100.0%)

2,802 (100.0%)

2,507 (100.0%)

Latin America & Caribbean

246 (4.2%)

109 (3.6%)

137 (5.0%)

246 (50.2%)

109 (42.9%)

137 (58.1%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Middle East & North Africa

52 (0.9%)

35 (1.1%)

17 (0.6%)

52 (10.6%)

35 (13.8%)

17 (7.2%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

North America

5 (0.1%)

3 (0.1%)

2 (0.1%)

5 (1.0%)

3 (1.2%)

2 (0.8%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

South Asia

27 (0.5%)

19 (0.6%)

8 (0.3%)

27 (5.5%)

19 (7.5%)

8 (3.4%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Sub-Saharan Africa

9 (0.2%)

6 (0.2%)

3 (0.1%)

9 (1.8%)

6 (2.4%)

3 (1.3%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Country of birth - Human Development Index

Min - Max

0.5 - 1.0

0.5 - 1.0

0.5 - 1.0

0.5 - 1.0

0.5 - 1.0

0.5 - 1.0

0.9 - 0.9

0.9 - 0.9

0.9 - 0.9

Median (Q1 - Q3)

0.9 (0.9 - 0.9)

0.9 (0.9 - 0.9)

0.9 (0.9 - 0.9)

0.8 (0.7 - 0.8)

0.8 (0.7 - 0.8)

0.8 (0.7 - 0.8)

0.9 (0.9 - 0.9)

0.9 (0.9 - 0.9)

0.9 (0.9 - 0.9)

Country of birth - Human Development Index category

High

184 (3.2%)

79 (2.6%)

105 (3.8%)

184 (37.6%)

79 (31.1%)

105 (44.5%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Low

19 (0.3%)

14 (0.5%)

5 (0.2%)

19 (3.9%)

14 (5.5%)

5 (2.1%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Medium

109 (1.9%)

59 (1.9%)

50 (1.8%)

109 (22.2%)

59 (23.2%)

50 (21.2%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Very High

5,487 (94.6%)

2,904 (95.0%)

2,583 (94.2%)

178 (36.3%)

102 (40.2%)

76 (32.2%)

5,309 (100.0%)

2,802 (100.0%)

2,507 (100.0%)

Country of citizenship (Dicotomic)

Non-Spain

234 (4.0%)

141 (4.6%)

93 (3.4%)

234 (47.8%)

141 (55.5%)

93 (39.4%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Spain

5,565 (96.0%)

2,915 (95.4%)

2,650 (96.6%)

256 (52.2%)

113 (44.5%)

143 (60.6%)

5,309 (100.0%)

2,802 (100.0%)

2,507 (100.0%)

Country of citizenship - World Region

East Asia & Pacific

14 (0.2%)

7 (0.2%)

7 (0.3%)

14 (2.9%)

7 (2.8%)

7 (3.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Europe & Central Asia

5,667 (97.7%)

2,980 (97.5%)

2,687 (98.0%)

358 (73.1%)

178 (70.1%)

180 (76.3%)

5,309 (100.0%)

2,802 (100.0%)

2,507 (100.0%)

Latin America & Caribbean

64 (1.1%)

32 (1.0%)

32 (1.2%)

64 (13.1%)

32 (12.6%)

32 (13.6%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Middle East & North Africa

26 (0.4%)

17 (0.6%)

9 (0.3%)

26 (5.3%)

17 (6.7%)

9 (3.8%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

North America

4 (0.1%)

3 (0.1%)

1 (0.0%)

4 (0.8%)

3 (1.2%)

1 (0.4%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

South Asia

19 (0.3%)

13 (0.4%)

6 (0.2%)

19 (3.9%)

13 (5.1%)

6 (2.5%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Sub-Saharan Africa

5 (0.1%)

4 (0.1%)

1 (0.0%)

5 (1.0%)

4 (1.6%)

1 (0.4%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Country of citizenship - Human Development Index

Min - Max

0.5 - 0.9

0.5 - 0.9

0.5 - 0.9

0.5 - 0.9

0.5 - 0.9

0.5 - 0.9

0.9 - 0.9

0.9 - 0.9

0.9 - 0.9

Median (Q1 - Q3)

0.9 (0.9 - 0.9)

0.9 (0.9 - 0.9)

0.9 (0.9 - 0.9)

0.9 (0.8 - 0.9)

0.9 (0.8 - 0.9)

0.9 (0.8 - 0.9)

0.9 (0.9 - 0.9)

0.9 (0.9 - 0.9)

0.9 (0.9 - 0.9)

Country of citizenship - Human Development Index category

High

64 (1.1%)

31 (1.0%)

33 (1.2%)

64 (13.1%)

31 (12.2%)

33 (14.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Low

14 (0.2%)

10 (0.3%)

4 (0.1%)

14 (2.9%)

10 (3.9%)

4 (1.7%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Medium

48 (0.8%)

28 (0.9%)

20 (0.7%)

48 (9.8%)

28 (11.0%)

20 (8.5%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Very High

5,673 (97.8%)

2,987 (97.7%)

2,686 (97.9%)

364 (74.3%)

185 (72.8%)

179 (75.8%)

5,309 (100.0%)

2,802 (100.0%)

2,507 (100.0%)

RCA document

DNI

5,568 (96.0%)

2,916 (95.4%)

2,652 (96.7%)

259 (52.9%)

114 (44.9%)

145 (61.4%)

5,309 (100.0%)

2,802 (100.0%)

2,507 (100.0%)

NIE

209 (3.6%)

130 (4.3%)

79 (2.9%)

209 (42.7%)

130 (51.2%)

79 (33.5%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Passeport

22 (0.4%)

10 (0.3%)

12 (0.4%)

22 (4.5%)

10 (3.9%)

12 (5.1%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Yearly income category

< 18.000 euros

3,252 (56.1%)

1,550 (50.7%)

1,702 (62.0%)

387 (79.0%)

194 (76.4%)

193 (81.8%)

2,865 (54.0%)

1,356 (48.4%)

1,509 (60.2%)

18.000 - 100.000 euros

2,475 (42.7%)

1,460 (47.8%)

1,015 (37.0%)

97 (19.8%)

56 (22.0%)

41 (17.4%)

2,378 (44.8%)

1,404 (50.1%)

974 (38.9%)

> 100.000 euros

72 (1.2%)

46 (1.5%)

26 (0.9%)

6 (1.2%)

4 (1.6%)

2 (0.8%)

66 (1.2%)

42 (1.5%)

24 (1.0%)

Health insurance at the time of surgery

5,792 (99.9%)

3,052 (99.9%)

2,740 (99.9%)

487 (99.4%)

253 (99.6%)

234 (99.2%)

5,305 (99.9%)

2,799 (99.9%)

2,506 (100.0%)

1n (%)

Crude incidence of SSI

Cumulative incidence

Both sexes: overall and by MS

The crude cumulative incidence in the group migrants is lower compared to the group of non-migrants. The CIR is lower than 1. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +           31          459        490        6.33 (4.34 to 8.86)
## Exposed -          440         4869       5309        8.29 (7.56 to 9.06)
## Total              471         5328       5799        8.12 (7.43 to 8.86)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.76 (0.54, 1.09)
## Inc odds ratio                                 0.75 (0.51, 1.09)
## Attrib risk in the exposed *                   -1.96 (-4.24, 0.32)
## Attrib fraction in the exposed (%)            -31.00 (-86.32, 7.89)
## Attrib risk in the population *                -0.17 (-1.19, 0.86)
## Attrib fraction in the population (%)         -2.04 (-4.44, 0.30)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 2.312 Pr>chi2 = 0.128
## Fisher exact test that OR = 1: Pr>chi2 = 0.142
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units

Females: overall and by MS

Among females, the crude cumulative incidence of SSI was lower among migrant compared to non-migrants. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +           16          220        236       6.78 (3.92 to 10.78)
## Exposed -          184         2323       2507        7.34 (6.35 to 8.43)
## Total              200         2543       2743        7.29 (6.35 to 8.33)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.92 (0.56, 1.51)
## Inc odds ratio                                 0.92 (0.54, 1.56)
## Attrib risk in the exposed *                   -0.56 (-3.93, 2.81)
## Attrib fraction in the exposed (%)            -8.26 (-77.26, 33.89)
## Attrib risk in the population *                -0.05 (-1.46, 1.36)
## Attrib fraction in the population (%)         -0.66 (-4.71, 3.23)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 0.100 Pr>chi2 = 0.752
## Fisher exact test that OR = 1: Pr>chi2 = 0.896
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units

Males: overall and by MS

Among males, the crude cumulative incidence of SSI was lower among migrant compared to non-migrants. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +           15          239        254        5.91 (3.34 to 9.55)
## Exposed -          256         2546       2802       9.14 (8.09 to 10.26)
## Total              271         2785       3056        8.87 (7.88 to 9.93)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.65 (0.39, 1.07)
## Inc odds ratio                                 0.62 (0.36, 1.07)
## Attrib risk in the exposed *                   -3.23 (-6.32, -0.14)
## Attrib fraction in the exposed (%)            -54.71 (-156.24, 6.59)
## Attrib risk in the population *                -0.27 (-1.74, 1.20)
## Attrib fraction in the population (%)         -3.03 (-5.97, -0.17)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 3.008 Pr>chi2 = 0.083
## Fisher exact test that OR = 1: Pr>chi2 = 0.084
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units

Both sexes: overall and by MS - Surgical procedure strata

Colon resection

Considering only colon resection procedures, the crude cumulative incidence of SSI in the group of migrants is lower compared to the group of non-migrants. CIR is lower than one. Differences are statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +            2           90         92        2.17 (0.26 to 7.63)
## Exposed -          115         1172       1287       8.94 (7.43 to 10.63)
## Total              117         1262       1379       8.48 (7.07 to 10.08)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.24 (0.06, 0.97)
## Inc odds ratio                                 0.23 (0.06, 0.93)
## Attrib risk in the exposed *                   -6.76 (-10.12, -3.40)
## Attrib fraction in the exposed (%)            -311.03 (-1536.77, -3.22)
## Attrib risk in the population *                -0.45 (-2.59, 1.69)
## Attrib fraction in the population (%)         -5.32 (-8.07, -2.63)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 5.056 Pr>chi2 = 0.025
## Fisher exact test that OR = 1: Pr>chi2 = 0.019
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
Rectal resection

Considering only rectal resection procedures, the crude cumulative incidence of SSI in the group of migrants is higher compared to the group of non-migrants. CIR is lower than one. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +           13           53         66     19.70 (10.93 to 31.32)
## Exposed -          109          515        624     17.47 (14.57 to 20.68)
## Total              122          568        690     17.68 (14.91 to 20.74)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 1.13 (0.67, 1.89)
## Inc odds ratio                                 1.16 (0.61, 2.20)
## Attrib risk in the exposed *                   2.23 (-7.82, 12.28)
## Attrib fraction in the exposed (%)            11.32 (-48.59, 47.07)
## Attrib risk in the population *                0.21 (-3.91, 4.33)
## Attrib fraction in the population (%)         1.21 (-4.39, 6.50)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 0.204 Pr>chi2 = 0.652
## Fisher exact test that OR = 1: Pr>chi2 = 0.614
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
Colon and/or rectal resection

Considering only colon and/or rectal resection surgeries, the crude cumulative incidence of SSI in the group of migrants is lower compared to the group of non-migrants. CIR is lower than one. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +           15          143        158       9.49 (5.41 to 15.17)
## Exposed -          224         1687       1911     11.72 (10.31 to 13.25)
## Total              239         1830       2069     11.55 (10.21 to 13.01)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.81 (0.49, 1.33)
## Inc odds ratio                                 0.79 (0.46, 1.37)
## Attrib risk in the exposed *                   -2.23 (-7.02, 2.56)
## Attrib fraction in the exposed (%)            -23.47 (-102.94, 24.88)
## Attrib risk in the population *                -0.17 (-2.16, 1.82)
## Attrib fraction in the population (%)         -1.47 (-4.70, 1.65)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 0.709 Pr>chi2 = 0.400
## Fisher exact test that OR = 1: Pr>chi2 = 0.516
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
Orthopedic interventions
TKA

Considering only TKA procedures, the crude cumulative incidence of SSI in the group of migrants is lower compared to the group of non-migrants. CIR is lower than one. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +            3           80         83       3.61 (0.75 to 10.20)
## Exposed -           53         1169       1222        4.34 (3.27 to 5.63)
## Total               56         1249       1305        4.29 (3.26 to 5.54)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.83 (0.27, 2.61)
## Inc odds ratio                                 0.83 (0.25, 2.71)
## Attrib risk in the exposed *                   -0.72 (-4.90, 3.45)
## Attrib fraction in the exposed (%)            -19.99 (-275.84, 61.69)
## Attrib risk in the population *                -0.05 (-1.63, 1.54)
## Attrib fraction in the population (%)         -1.07 (-7.45, 4.93)
## -------------------------------------------------------------------
## Yates corrected chi2 test that OR = 1: chi2(1) = 0.001 Pr>chi2 = 0.972
## Fisher exact test that OR = 1: Pr>chi2 = 1.000
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
THA

Considering only THA procedures, the crude cumulative incidence of SSI in the group of migrants is lower compared to the group of non-migrants. CIR is lower than one. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +            2           99        101        1.98 (0.24 to 6.97)
## Exposed -           47         1043       1090        4.31 (3.19 to 5.69)
## Total               49         1142       1191        4.11 (3.06 to 5.40)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.46 (0.11, 1.86)
## Inc odds ratio                                 0.45 (0.11, 1.87)
## Attrib risk in the exposed *                   -2.33 (-5.30, 0.64)
## Attrib fraction in the exposed (%)            -117.75 (-783.31, 46.32)
## Attrib risk in the population *                -0.20 (-1.85, 1.45)
## Attrib fraction in the population (%)         -4.81 (-11.05, 1.09)
## -------------------------------------------------------------------
## Yates corrected chi2 test that OR = 1: chi2(1) = 0.751 Pr>chi2 = 0.386
## Fisher exact test that OR = 1: Pr>chi2 = 0.427
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
All orthopedic procedures combined

Considering all orthopedic procedures procedures, the crude cumulative incidence of SSI in the group of migrants is lower compared to the group of non-migrants. CIR is lower than one. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +            5          179        184        2.72 (0.89 to 6.23)
## Exposed -          100         2212       2312        4.33 (3.53 to 5.24)
## Total              105         2391       2496        4.21 (3.45 to 5.07)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.63 (0.26, 1.52)
## Inc odds ratio                                 0.62 (0.25, 1.54)
## Attrib risk in the exposed *                   -1.61 (-4.10, 0.88)
## Attrib fraction in the exposed (%)            -59.17 (-285.87, 34.34)
## Attrib risk in the population *                -0.12 (-1.26, 1.03)
## Attrib fraction in the population (%)         -2.82 (-7.27, 1.45)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 1.093 Pr>chi2 = 0.296
## Fisher exact test that OR = 1: Pr>chi2 = 0.442
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
Cardiac procedures
CABG

Considering only CABG procedures, the crude cumulative incidence of SSI in the group of migrants is lower compared to the group of non-migrants. CIR is lower than one. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +           10           98        108       9.26 (4.53 to 16.37)
## Exposed -           90          633        723     12.45 (10.13 to 15.08)
## Total              100          731        831      12.03 (9.90 to 14.44)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.74 (0.40, 1.38)
## Inc odds ratio                                 0.72 (0.36, 1.43)
## Attrib risk in the exposed *                   -3.19 (-9.16, 2.78)
## Attrib fraction in the exposed (%)            -34.44 (-150.23, 27.77)
## Attrib risk in the population *                -0.41 (-3.68, 2.85)
## Attrib fraction in the population (%)         -3.44 (-10.11, 2.82)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 0.903 Pr>chi2 = 0.342
## Fisher exact test that OR = 1: Pr>chi2 = 0.428
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
Valve replacement

Considering only valve replacement procedures, there were no SSI events in the migrants group, therefore the crude cumulative incidence cannot be computed.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +            0           37         37        0.00 (0.00 to 9.49)
## Exposed -           14          278        292        4.79 (2.65 to 7.91)
## Total               14          315        329        4.26 (2.35 to 7.04)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 NaN (NaN, NaN)
## Inc odds ratio                                 NaN (NaN, NaN)
## Attrib risk in the exposed *                   -4.79 (-7.25, -2.34)
## Attrib fraction in the exposed (%)            NaN (NaN, NaN)
## Attrib risk in the population *                -0.54 (-3.82, 2.74)
## Attrib fraction in the population (%)         -12.67 (-17.09, -8.42)
## -------------------------------------------------------------------
## Yates corrected chi2 test that OR = 1: chi2(1) = 0.863 Pr>chi2 = 0.353
## Fisher exact test that OR = 1: Pr>chi2 = 0.381
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
CABG + valve

Considering only CABG + valve replacement procedures, the crude cumulative incidence of SSI in the group of migrants is higher compared to the group of non-migrants. CIR is higher than one. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +            1            2          3      33.33 (0.84 to 90.57)
## Exposed -           12           59         71      16.90 (9.05 to 27.66)
## Total               13           61         74      17.57 (9.70 to 28.17)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 1.97 (0.37, 10.60)
## Inc odds ratio                                 2.46 (0.21, 29.34)
## Attrib risk in the exposed *                   16.43 (-37.62, 70.48)
## Attrib fraction in the exposed (%)            49.30 (-172.43, 90.56)
## Attrib risk in the population *                0.67 (-11.63, 12.96)
## Attrib fraction in the population (%)         3.79 (-10.22, 16.03)
## -------------------------------------------------------------------
## Yates corrected chi2 test that OR = 1: chi2(1) = 0.000 Pr>chi2 = 1.000
## Fisher exact test that OR = 1: Pr>chi2 = 0.445
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units
All cardiac procedures combined

Considering only cardiac procedures, the crude cumulative incidence of SSI in the group of migrants is lower compared to the group of non-migrants. CIR is lower than one. Differences are not statistically significant.

##              Outcome +    Outcome -      Total                 Inc risk *
## Exposed +           11          137        148       7.43 (3.77 to 12.91)
## Exposed -          116          970       1086      10.68 (8.91 to 12.67)
## Total              127         1107       1234      10.29 (8.65 to 12.12)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc risk ratio                                 0.70 (0.38, 1.26)
## Inc odds ratio                                 0.67 (0.35, 1.28)
## Attrib risk in the exposed *                   -3.25 (-7.86, 1.36)
## Attrib fraction in the exposed (%)            -43.71 (-160.30, 20.65)
## Attrib risk in the population *                -0.39 (-2.89, 2.11)
## Attrib fraction in the population (%)         -3.79 (-9.30, 1.45)
## -------------------------------------------------------------------
## Uncorrected chi2 test that OR = 1: chi2(1) = 1.489 Pr>chi2 = 0.222
## Fisher exact test that OR = 1: Pr>chi2 = 0.251
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 100 population units

Incidence rate

Both sexes: overall and by MS

The crude incidence rate in the group migrants is lower compared to the group of non-migrants. The IRR is lower than 1. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +           31           33297        0.93 (0.63 to 1.32)
## Exposed -          440          344265        1.28 (1.16 to 1.40)
## Total              471          377562        1.25 (1.14 to 1.37)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.73 (0.49, 1.05)
## Attrib rate in the exposed *                   -0.35 (-0.70, 0.00)
## Attrib fraction in the exposed (%)            -37.28 (-104.52, 4.68)
## Attrib rate in the population *                -0.03 (-0.19, 0.13)
## Attrib fraction in the population (%)         -2.45 (-2.77, -2.12)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk

Females: overall and by MS

Among females, the crude incidence rate in the group migrants is lower compared to the group of non-migrants. The IRR is lower than 1. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +           16           15998        1.00 (0.57 to 1.62)
## Exposed -          184          165799        1.11 (0.96 to 1.28)
## Total              200          181797        1.10 (0.95 to 1.26)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.90 (0.50, 1.50)
## Attrib rate in the exposed *                   -0.11 (-0.63, 0.41)
## Attrib fraction in the exposed (%)            -10.96 (-98.23, 33.47)
## Attrib rate in the population *                -0.01 (-0.23, 0.21)
## Attrib fraction in the population (%)         -0.88 (-1.47, -0.24)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk

Males: overall and by MS

Among males, the crude incidence rate in the group migrants is lower compared to the group of non-migrants. The IRR is lower than 1. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +           15           17299        0.87 (0.49 to 1.43)
## Exposed -          256          178466        1.43 (1.26 to 1.62)
## Total              271          195765        1.38 (1.22 to 1.56)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.60 (0.33, 1.02)
## Attrib rate in the exposed *                   -0.57 (-1.04, -0.09)
## Attrib fraction in the exposed (%)            -65.43 (-199.93, 1.57)
## Attrib rate in the population *                -0.05 (-0.29, 0.19)
## Attrib fraction in the population (%)         -3.62 (-3.98, -3.24)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk

Both sexes: overall and by MS - Surgical procedure strata

Colon resection

Considering only colon resection procedures, the crude incidence rate of SSI in the group of migrants is lower compared to the group of non-migrants. IRR is lower than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +            2            2706        0.74 (0.09 to 2.67)
## Exposed -          115           36248        3.17 (2.62 to 3.81)
## Total              117           38954        3.00 (2.48 to 3.60)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.23 (0.03, 0.86)
## Attrib rate in the exposed *                   -2.43 (-3.61, -1.26)
## Attrib fraction in the exposed (%)            -329.25 (-3486.93, -16.16)
## Attrib rate in the population *                -0.17 (-0.96, 0.63)
## Attrib fraction in the population (%)         -5.63 (-5.79, -5.45)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk
Rectal resection

Considering only rectal resection procedures, the crude incidence rate of SSI in the group of migrants is higher compared to the group of non-migrants. IRR is higher than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +           13            1763       7.37 (3.93 to 12.61)
## Exposed -          109           16549        6.59 (5.41 to 7.95)
## Total              122           18312        6.66 (5.53 to 7.95)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 1.12 (0.58, 2.00)
## Attrib rate in the exposed *                   0.79 (-3.41, 4.98)
## Attrib fraction in the exposed (%)            10.68 (-73.12, 49.89)
## Attrib rate in the population *                0.08 (-1.63, 1.79)
## Attrib fraction in the population (%)         1.14 (0.12, 2.25)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk
Colon and/or rectal resection

Considering only colon and/or rectal resection surgeries, the crude IR of SSI in the group of migrants is lower compared to the group of non-migrants. IRR is lower than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +           15            4469        3.36 (1.88 to 5.54)
## Exposed -          224           52797        4.24 (3.71 to 4.84)
## Total              239           57266        4.17 (3.66 to 4.74)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.79 (0.44, 1.33)
## Attrib rate in the exposed *                   -0.89 (-2.67, 0.90)
## Attrib fraction in the exposed (%)            -26.40 (-129.64, 24.99)
## Attrib rate in the population *                -0.07 (-0.84, 0.70)
## Attrib fraction in the population (%)         -1.66 (-2.08, -1.20)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk
Orthopedic interventions
TKA

Considering only TKA procedures, the IR of SSI in the group of migrants is lower compared to the group of non-migrants. IRR is lower than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +            3            7301       4.11 (0.85 to 12.01)
## Exposed -           53          106725        4.97 (3.72 to 6.50)
## Total               56          114026        4.91 (3.71 to 6.38)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.83 (0.17, 2.55)
## Attrib rate in the exposed *                   -0.86 (-5.70, 3.98)
## Attrib fraction in the exposed (%)            -20.86 (-504.67, 60.83)
## Attrib rate in the population *                -0.05 (-1.91, 1.80)
## Attrib fraction in the population (%)         -1.12 (-1.85, -0.27)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 10000 units of population time at risk
THA

Considering only THA procedures, the IR of SSI in the group of migrants is lower compared to the group of non-migrants. IRR is lower than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +            2            8973        2.23 (0.27 to 8.05)
## Exposed -           47           95101        4.94 (3.63 to 6.57)
## Total               49          104074        4.71 (3.48 to 6.22)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.45 (0.05, 1.72)
## Attrib rate in the exposed *                   -2.71 (-6.11, 0.68)
## Attrib fraction in the exposed (%)            -121.73 (-1784.49, 41.94)
## Attrib rate in the population *                -0.23 (-2.17, 1.70)
## Attrib fraction in the population (%)         -4.97 (-5.58, -4.25)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 10000 units of population time at risk
All orthopedic procedures combined

Considering all orthopedic procedures combined, the crude IR of SSI in the group of migrants is lower compared to the group of non-migrants. IRR is lower than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +            5           16274        3.07 (1.00 to 7.17)
## Exposed -          100          201826        4.95 (4.03 to 6.03)
## Total              105          218100        4.81 (3.94 to 5.83)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.62 (0.20, 1.50)
## Attrib rate in the exposed *                   -1.88 (-4.75, 0.98)
## Attrib fraction in the exposed (%)            -61.27 (-407.49, 33.15)
## Attrib rate in the population *                -0.14 (-1.48, 1.20)
## Attrib fraction in the population (%)         -2.92 (-3.40, -2.38)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 10000 units of population time at risk
Cardiac procedures
CABG

Considering only CABG procedures, the crude IR of SSI in the group of migrants is lower compared to the group of non-migrants. IRR is lower than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +           10            9079        1.10 (0.53 to 2.03)
## Exposed -           90           58931        1.53 (1.23 to 1.88)
## Total              100           68010        1.47 (1.20 to 1.79)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.72 (0.33, 1.39)
## Attrib rate in the exposed *                   -0.43 (-1.18, 0.33)
## Attrib fraction in the exposed (%)            -38.66 (-198.98, 27.98)
## Attrib rate in the population *                -0.06 (-0.48, 0.37)
## Attrib fraction in the population (%)         -3.87 (-4.97, -2.65)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk
Valve replacement

Considering only valve replacement procedures, there were no SSI events in the migrants group, therefore the IR cannot be computed.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +            0            3249        0.00 (0.00 to 1.14)
## Exposed -           14           25111        0.56 (0.30 to 0.94)
## Total               14           28360        0.49 (0.27 to 0.83)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 NaN (NaN, NaN)
## Attrib rate in the exposed *                   -0.56 (-0.85, -0.27)
## Attrib fraction in the exposed (%)            NaN (NaN, NaN)
## Attrib rate in the population *                -0.06 (-0.45, 0.33)
## Attrib fraction in the population (%)         -12.94 (-12.94, -12.94)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk
CABG + valve

Considering only CABG + valve replacement procedures, the IR of SSI in the group of migrants is higher compared to the group of non-migrants. IRR is higher than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +            1             226       4.42 (0.11 to 24.65)
## Exposed -           12            5600        2.14 (1.11 to 3.74)
## Total               13            5826        2.23 (1.19 to 3.82)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 2.06 (0.05, 13.96)
## Attrib rate in the exposed *                   2.28 (-6.47, 11.04)
## Attrib fraction in the exposed (%)            51.57 (-1970.21, 92.83)
## Attrib rate in the population *                0.09 (-1.63, 1.80)
## Attrib fraction in the population (%)         3.97 (1.90, 6.81)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk
All cardiac procedures combined

Considering all cardiac procedures combined, the crude IR of SSI in the group of migrants is lower compared to the group of non-migrants. IR is lower than one. Differences are not statistically significant.

##              Outcome +    Time at risk                 Inc rate *
## Exposed +           11           12554        0.88 (0.44 to 1.57)
## Exposed -          116           89642        1.29 (1.07 to 1.55)
## Total              127          102196        1.24 (1.04 to 1.48)
## 
## Point estimates and 95% CIs:
## -------------------------------------------------------------------
## Inc rate ratio                                 0.68 (0.33, 1.26)
## Attrib rate in the exposed *                   -0.42 (-0.99, 0.15)
## Attrib fraction in the exposed (%)            -47.68 (-204.05, 20.45)
## Attrib rate in the population *                -0.05 (-0.37, 0.27)
## Attrib fraction in the population (%)         -4.13 (-4.97, -3.21)
## -------------------------------------------------------------------
##  Wald confidence limits
##  CI: confidence interval
##  * Outcomes per 1000 units of population time at risk

Bivariate analysis - SSI

We perform a bivariate analysis to identify variables associated with SSI.

Appropriate tests are performed:

Variable
SSI
p-value2
No
N = 5,328
1
Yes
N = 471
1
Age

0.007
    Min - Max 16 - 95.0 26 - 89.0
    Mean (SD) 66 (12.5) 65 (12.6)
Sex

0.032
    Male 2,785 (52.3%) 271 (57.5%)
    Female 2,543 (47.7%) 200 (42.5%)
Migration Status 459 (8.6%) 31 (6.6%) 0.152
Surgery Year categories

<0.001
    2007-2014 1,904 (35.7%) 117 (24.8%)
    2015-2019 1,225 (23.0%) 133 (28.2%)
    2020-2024 2,199 (41.3%) 221 (46.9%)
Surgical procedure (study classification)

<0.001
    THA 1,142 (21.4%) 49 (10.4%)
    TKA 1,249 (23.4%) 56 (11.9%)
    Valve replacement 315 (5.9%) 14 (3.0%)
    CABG + valve 61 (1.1%) 13 (2.8%)
    Colon or rectal resection 1,830 (34.3%) 239 (50.7%)
    CABG 731 (13.7%) 100 (21.2%)
Preoperative length of stay (days)

<0.001
    Min - Max 0 - 59.0 0 - 52.0
    Median (Q1 - Q3) 1 (0.0 - 1) 1 (1.0 - 1)
ASA classification

<0.001
    I 438 (8.2%) 17 (3.6%)
    II 2,971 (55.8%) 240 (51.0%)
    III 1,416 (26.6%) 141 (29.9%)
    IV 499 (9.4%) 73 (15.5%)
    V 4 (0.1%) 0 (0.0%)
Degree of urgency

0.156
    Elective 5,219 (98.0%) 456 (96.8%)
    Urgent 5 (0.1%) 1 (0.2%)
    Semi-elective 104 (2.0%) 14 (3.0%)
Wound class

<0.001
    Clean 3,500 (65.7%) 233 (49.5%)
    Clean-contaminated 1,544 (29.0%) 200 (42.5%)
    Contaminated 280 (5.3%) 37 (7.9%)
    Infected 4 (0.1%) 1 (0.2%)
Antibiotic prophylaxis

0.301
    Adequate 4,986 (93.6%) 447 (94.9%)
    Inadequate 342 (6.4%) 24 (5.1%)
Minimally invasive surgery 1,649 (30.9%) 178 (37.8%) 0.003
Surgery duration (minutes)

<0.001
    Min - Max 4 - 943.0 14 - 1,685.0
    Median (Q1 - Q3) 120 (90.0 - 180) 164 (110.0 - 235)
Country of birth (Dicotomic)

0.117
    Non-Spain 457 (8.6%) 30 (6.4%)
    Spain 4,871 (91.4%) 441 (93.6%)
Country of birth - World Region

0.692
    East Asia & Pacific 26 (0.5%) 2 (0.4%)
    Europe & Central Asia 4,985 (93.6%) 447 (94.9%)
    Latin America & Caribbean 228 (4.3%) 18 (3.8%)
    Middle East & North Africa 51 (1.0%) 1 (0.2%)
    North America 5 (0.1%) 0 (0.0%)
    South Asia 25 (0.5%) 2 (0.4%)
    Sub-Saharan Africa 8 (0.2%) 1 (0.2%)
Country of birth - Human Development Index

0.265
    Min - Max 0.5 - 1.0 0.6 - 0.9
    Median (Q1 - Q3) 0.9 (0.9 - 0.9) 0.9 (0.9 - 0.9)
Country of birth - Human Development Index category

0.576
    High 171 (3.2%) 13 (2.8%)
    Low 19 (0.4%) 0 (0.0%)
    Medium 100 (1.9%) 9 (1.9%)
    Very High 5,038 (94.6%) 449 (95.3%)
Country of citizenship (Dicotomic)

0.715
    Non-Spain 213 (4.0%) 21 (4.5%)
    Spain 5,115 (96.0%) 450 (95.5%)
Country of citizenship - World Region

0.697
    East Asia & Pacific 12 (0.2%) 2 (0.4%)
    Europe & Central Asia 5,208 (97.7%) 459 (97.5%)
    Latin America & Caribbean 58 (1.1%) 6 (1.3%)
    Middle East & North Africa 24 (0.5%) 2 (0.4%)
    North America 4 (0.1%) 0 (0.0%)
    South Asia 18 (0.3%) 1 (0.2%)
    Sub-Saharan Africa 4 (0.1%) 1 (0.2%)
Country of citizenship - Human Development Index

0.702
    Min - Max 0.5 - 0.9 0.6 - 0.9
    Median (Q1 - Q3) 0.9 (0.9 - 0.9) 0.9 (0.9 - 0.9)
Country of citizenship - Human Development Index category

0.468
    High 58 (1.1%) 6 (1.3%)
    Low 14 (0.3%) 0 (0.0%)
    Medium 42 (0.8%) 6 (1.3%)
    Very High 5,214 (97.9%) 459 (97.5%)
RCA document

0.673
    DNI 5,118 (96.1%) 450 (95.5%)
    NIE 189 (3.5%) 20 (4.2%)
    Passeport 21 (0.4%) 1 (0.2%)
Yearly income category

0.676
    < 18.000 euros 2,997 (56.3%) 255 (54.1%)
    18.000 - 100.000 euros 2,265 (42.5%) 210 (44.6%)
    > 100.000 euros 66 (1.2%) 6 (1.3%)
Health insurance at the time of surgery 5,321 (99.9%) 471 (100.0%) >0.999
1 n (%)
2 Welch Two Sample t-test; Pearson’s Chi-squared test; Wilcoxon rank sum test; Fisher’s exact test

Variables statistically associated to SSI (p<0.05):

  1. Age: mean age was higher among non-infected patients

  2. Sex: the proportion of males was higher among infected patients

  3. Surgery year: the proportion of patients intervened in the 2015-2019 and 2019-2024 periods was higher among the infected compared to the non-infected group.

  4. Surgical procedure: among patients that had an infection, the proportion of patients that had colorectal resection, CABG and CABG + valve was higher, compared to patients with no infection, while the proportion of patients that had orthopedic surgeries or valve replacement was lower.

  5. Preoperative length of stay: higher among the infected group

  6. ASA classification: among patients that had an infection, the proportion of patients that had an ASA classification I or II was lower, while the proportion of patients that had an ASA classification III or IV was higher.

  7. Wound class: among patients that had an infection, the proportion of patients that had a clean wound was lower, while the proportion of patients that had a clean-contaminated or contaminated wound was higher.

  8. Minimally invasive surgery: the proportion of patients that underwent a minimally invasive surgery was higher among the infected group

  9. Surgery duration: The median duration of the surgical procedure was higher among the infected group.

Additionally, variables with a p-value lower than 0.20:

  1. Migration status

  2. Degree of urgency

  3. Country of birth (dicotomic)