GSE102349 (N=107)	GSE224450 (N=22)	QL1706 (N=33)	Rationale309 (N=263)	P-value
Age (years)
Mean (SD)	46.1 (12.1)	52.9 (10.9)	44.1 (8.79)	49.3 (10.7)	0.426
Median [Min, Max]	46.0 [17.0, 80.0]	52.0 [23.0, 73.0]	41.0 [32.0, 64.0]	50.0 [23.0, 74.0]
Missing	1 (0.9%)	0 (0%)	0 (0%)	0 (0%)
Gender
Female	25 (23.4%)	6 (27.3%)	7 (21.2%)	57 (21.7%)	0.748
Male	81 (75.7%)	16 (72.7%)	26 (78.8%)	206 (78.3%)
unknown	1 (0.9%)	0 (0%)	0 (0%)	0 (0%)
Smoking
No	43 (40.2%)	11 (50.0%)	26 (78.8%)	140 (53.2%)	<0.001
Yes	30 (28.0%)	10 (45.5%)	7 (21.2%)	123 (46.8%)
unknown	34 (31.8%)	0 (0%)	0 (0%)	0 (0%)
Missing	0 (0%)	1 (4.5%)	0 (0%)	0 (0%)
ECOG
0	0 (0%)	0 (0%)	14 (42.4%)	97 (36.9%)	<0.001
1	0 (0%)	0 (0%)	19 (57.6%)	166 (63.1%)
unknown	107 (100%)	22 (100%)	0 (0%)	0 (0%)
Liver.metastasis
no	14 (13.1%)	0 (0%)	15 (45.5%)	150 (57.0%)	<0.001
yes	7 (6.5%)	0 (0%)	18 (54.5%)	113 (43.0%)
unknown	86 (80.4%)	0 (0%)	0 (0%)	0 (0%)
Yes	0 (0%)	14 (63.6%)	0 (0%)	0 (0%)
No	0 (0%)	7 (31.8%)	0 (0%)	0 (0%)
Missing	0 (0%)	1 (4.5%)	0 (0%)	0 (0%)
Treatment
Naive	107 (100%)	0 (0%)	0 (0%)	0 (0%)	<0.001
nivolumab+ipilimumab	0 (0%)	22 (100%)	0 (0%)	0 (0%)
QL1706	0 (0%)	0 (0%)	33 (100%)	0 (0%)
GP	0 (0%)	0 (0%)	0 (0%)	123 (46.8%)
Immuno+GP	0 (0%)	0 (0%)	0 (0%)	124 (47.1%)
Missing	0 (0%)	0 (0%)	0 (0%)	16 (6.1%)