Combined Cox Regression Results
Univariable and Multivariable Analysis
Univariable Analysis
Multivariable Analysis
HR 95% CI p-value n HR 95% CI p-value
Age (continuous)
Per year 1.04 (1.03–1.05) 0.000
Median (IQR) NA NA NA 37.0 (24.0–51.0)
Sex
Female 1.00
Male 0.93 (0.72–1.20) 0.576
GCS
Severe (7–8) 1.00 256 1 (ref)
Severe (5–6) 1.48 (1.10–1.99) 0.009 168 1.79 (1.27–2.52) 0.001
Severe (3–4) 3.21 (2.46–4.17) 0.000 195 3.72 (2.76–5.01) 0.000
Pupil Reactivity
Reactive 1.00 64 1 (ref)
Sluggish 1.31 (0.89–1.94) 0.169 170 1.44 (0.94–2.21) 0.094
None 1.05 (0.73–1.53) 0.781 385 0.99 (0.67–1.48) 0.978
Unknown 1 (ref)
Motor Score
1 - No motor response 1.00
2 - Extension to pain (decerebrate) 0.93 (0.66–1.31) 0.690
3 - Flexion to pain (decorticate) 0.71 (0.49–1.03) 0.075
4 - Withdraws from pain 0.41 (0.29–0.58) 0.000
5 - Localizes pain 0.38 (0.28–0.50) 0.000
6 - Obeys commands 0.62 (0.30–1.27) 0.190
Craniotomy
No 1.00 543 1 (ref)
Yes 0.80 (0.58–1.10) 0.169 76 0.72 (0.47–1.10) 0.133
DHC
No 1.00 439 1 (ref)
Yes 1.59 (1.25–2.01) 0.000 180 0.99 (0.69–1.41) 0.948
Hypotension
No 1.00 454 1 (ref)
Yes 1.55 (1.21–1.97) 0.000 165 1.75 (1.32–2.31) 0.000
CT Classification
Normal CT scan 1.00 26 1 (ref)
Diffuse injury I 0.68 (0.38–1.22) 0.198 311 0.51 (0.25–1.07) 0.074
Diffuse injury II 1.97 (1.08–3.59) 0.027 83 1.55 (0.71–3.37) 0.273
Diffuse injury III (Swelling) 1.68 (0.87–3.23) 0.120 47 1.17 (0.49–2.77) 0.729
Diffuse injury IV 1.40 (0.78–2.53) 0.262 118 0.95 (0.41–2.19) 0.901
Evacuated mass lesion 3.02 (1.59–5.73) 0.001 34 2.67 (1.14–6.25) 0.024
tSAH on CT
No 1.00 133 1 (ref)
Yes 2.00 (1.50–2.67) 0.000 486 1.46 (0.99–2.14) 0.054
Epidural Mass on CT
No 1.00
Yes 0.93 (0.66–1.31) 0.686
Glucose Range (g/dL)
<80 0.80 (0.25–2.61) 0.715 9 0.71 (0.17–2.99) 0.637
80–110 1.00 98 1 (ref)
111–140 1.18 (0.79–1.76) 0.410 172 1.18 (0.77–1.80) 0.450
>140 1.78 (1.25–2.54) 0.001 340 1.29 (0.89–1.88) 0.175
Hb Range (g/dL)
<10 1.38 (1.00–1.90) 0.049 72 1.31 (0.91–1.88) 0.144
10–12 0.94 (0.70–1.26) 0.672 124 0.93 (0.66–1.31) 0.683
12–14 1.00 228 1 (ref)
>14 0.83 (0.63–1.10) 0.189 195 0.95 (0.70–1.30) 0.763
Hypoxia
No 1.00
Yes 1.20 (0.92–1.56) 0.175