| Serum Lab Values |
| Serum WBC (IQR) |
8.17 [5.68, 11.40] |
8.52 [6.55, 11.26] |
8.52 [5.58, 11.94] |
5.67 [3.01, 9.77] |
8.41 [5.88, 11.80] |
<0.001 |
77 |
Serum Lab Values |
| CSF Lab Values |
| CSF Admission Day (IQR) |
1.00 [0.85, 4.00] |
1.00 [0.65, 3.00] |
2.00 [0.44, 4.00] |
3.00 [1.00, 10.00] |
1.00 [0.00, 3.75] |
<0.001 |
62 |
CSF Lab Values |
| CSF Protein (IQR) |
47.50 [31.70, 78.05] |
51.00 [34.00, 85.17] |
45.00 [30.00, 69.00] |
50.65 [35.02, 83.30] |
32.70 [25.40, 52.50] |
<0.001 |
63 |
CSF Lab Values |
| CSF Total Protein < 60, n (%) |
834 (64.0) |
347 (59.4) |
311 (68.4) |
102 (57.3) |
74 (86.0) |
<0.001 |
65 |
CSF Lab Values |
| CSF Total Protein ≥ 60, n (%) |
469 (36.0) |
237 (40.6) |
144 (31.6) |
76 (42.7) |
12 (14.0) |
<0.001 |
66 |
CSF Lab Values |
| CSF Glucose (IQR) |
68.00 [58.00, 85.00] |
68.00 [57.00, 84.25] |
70.00 [59.00, 89.00] |
66.00 [57.00, 81.00] |
65.00 [58.25, 80.00] |
0.015 |
67 |
CSF Lab Values |
| CSF Total Nucleated Cell Count (IQR) |
3.00 [1.00, 21.00] |
4.00 [1.00, 37.25] |
2.00 [1.00, 9.00] |
4.00 [1.00, 19.75] |
1.00 [0.00, 6.75] |
<0.001 |
68 |
CSF Lab Values |
| CSF Total Nucleated Cell Count < 5, n (%) |
769 (59.0) |
306 (52.4) |
305 (66.9) |
96 (53.9) |
62 (72.1) |
<0.001 |
70 |
CSF Lab Values |
| CSF Total Nucleated Cell Count ≥ 5, n (%) |
535 (41.0) |
278 (47.6) |
151 (33.1) |
82 (46.1) |
24 (27.9) |
<0.001 |
71 |
CSF Lab Values |
| CSF Lymphocyte Count (IQR) |
66.00 [25.00, 86.00] |
71.00 [34.00, 88.00] |
58.50 [19.00, 82.25] |
66.00 [25.00, 88.75] |
65.00 [3.00, 80.00] |
0.001 |
72 |
CSF Lab Values |
| Normal CSF Cell Count (CSF TNC < 5), n (%) |
769 (59.0) |
306 (52.4) |
305 (66.9) |
96 (53.9) |
62 (72.1) |
<0.001 |
74 |
CSF Lab Values |
| Pleocytosis (Lymph ≥ 50%), n (%) |
350 (26.8) |
193 (33.0) |
93 (20.4) |
51 (28.7) |
13 (15.1) |
<0.001 |
75 |
CSF Lab Values |
| Pleocytosis (Lymph < 50%), n (%) |
185 (14.2) |
85 (14.6) |
58 (12.7) |
31 (17.4) |
11 (12.8) |
<0.001 |
76 |
CSF Lab Values |
| Seasonal Testing |
| Test Sent Off-Season, n (%) |
479 (36.7) |
226 (38.7) |
158 (34.6) |
67 (37.6) |
28 (32.6) |
0.470 |
60 |
Seasonal Testing |
| Test Sent June-Nov, n (%) |
825 (63.3) |
358 (61.3) |
298 (65.4) |
111 (62.4) |
58 (67.4) |
0.470 |
61 |
Seasonal Testing |
| Clinical History |
| Immunocompetent, n (%) |
1133 (86.9) |
564 (96.6) |
403 (88.4) |
96 (53.9) |
70 (81.4) |
<0.001 |
51 |
Clinical History |
| Immunosuppressed, n (%) |
171 (13.1) |
20 (3.4) |
53 (11.6) |
82 (46.1) |
16 (18.6) |
<0.001 |
52 |
Clinical History |
| No Transplant, n (%) |
1160 (89.0) |
573 (98.1) |
410 (89.9) |
106 (59.6) |
71 (82.6) |
<0.001 |
54 |
Clinical History |
| History of Transplant, n (%) |
144 (11.0) |
11 (1.9) |
46 (10.1) |
72 (40.4) |
15 (17.4) |
<0.001 |
55 |
Clinical History |
| No B-cell Depleting Meds, n (%) |
1271 (97.5) |
575 (98.5) |
446 (97.8) |
165 (92.7) |
85 (98.8) |
<0.001 |
57 |
Clinical History |
| B-cell Depletion, n (%) |
33 (2.5) |
9 (1.5) |
10 (2.2) |
13 (7.3) |
1 (1.2) |
<0.001 |
58 |
Clinical History |
| CDC WNV Testing Guideline Adherence |
| Does Not Follow, n (%) |
969 (74.3) |
374 (64.0) |
367 (80.5) |
156 (87.6) |
72 (83.7) |
<0.001 |
47 |
CDC WNV Testing Guideline Adherence |
| Follows, n (%) |
168 (12.9) |
99 (17.0) |
50 (11.0) |
10 (5.6) |
9 (10.5) |
<0.001 |
48 |
CDC WNV Testing Guideline Adherence |
| Follows but Over-Tested, n (%) |
167 (12.8) |
111 (19.0) |
39 (8.6) |
12 (6.7) |
5 (5.8) |
<0.001 |
49 |
CDC WNV Testing Guideline Adherence |
| Serum West Nile Virus IgM |
| Serum IgM Ordered No, n (%) |
1169 (89.6) |
506 (86.6) |
419 (91.9) |
165 (92.7) |
79 (91.9) |
0.016 |
39 |
Serum West Nile Virus IgM |
| Serum IgM Ordered Yes, n (%) |
135 (10.4) |
78 (13.4) |
37 (8.1) |
13 (7.3) |
7 (8.1) |
0.016 |
40 |
Serum West Nile Virus IgM |
| No Result, n (%) |
14 (1.1) |
3 (0.5) |
9 (2.0) |
0 (0.0) |
2 (2.3) |
0.001 |
42 |
Serum West Nile Virus IgM |
| Positive, n (%) |
11 (0.8) |
4 (0.7) |
6 (1.3) |
1 (0.6) |
0 (0.0) |
0.001 |
43 |
Serum West Nile Virus IgM |
| Negative, n (%) |
110 (8.4) |
71 (12.2) |
22 (4.8) |
12 (6.7) |
5 (5.8) |
0.001 |
44 |
Serum West Nile Virus IgM |
| Not Ordered, n (%) |
1169 (89.6) |
506 (86.6) |
419 (91.9) |
165 (92.7) |
79 (91.9) |
0.001 |
45 |
Serum West Nile Virus IgM |
| CSF West Nile Virus IgM |
| CSF IgM Ordered No, n (%) |
951 (72.9) |
369 (63.2) |
361 (79.2) |
150 (84.3) |
71 (82.6) |
<0.001 |
31 |
CSF West Nile Virus IgM |
| CSF IgM Ordered Yes, n (%) |
353 (27.1) |
215 (36.8) |
95 (20.8) |
28 (15.7) |
15 (17.4) |
<0.001 |
32 |
CSF West Nile Virus IgM |
| CSF IgM No Result, n (%) |
63 (4.8) |
37 (6.3) |
15 (3.3) |
6 (3.4) |
5 (5.8) |
<0.001 |
34 |
CSF West Nile Virus IgM |
| CSF IgM Positive, n (%) |
20 (1.5) |
5 (0.9) |
13 (2.9) |
2 (1.1) |
0 (0.0) |
<0.001 |
35 |
CSF West Nile Virus IgM |
| CSF IgM Negative, n (%) |
270 (20.7) |
173 (29.6) |
67 (14.7) |
20 (11.2) |
10 (11.6) |
<0.001 |
36 |
CSF West Nile Virus IgM |
| CSF IgM Not Ordered, n (%) |
951 (72.9) |
369 (63.2) |
361 (79.2) |
150 (84.3) |
71 (82.6) |
<0.001 |
37 |
CSF West Nile Virus IgM |
| CSF West Nile Virus RT-PCR |
| CSF PCR Ordered No, n (%) |
171 (13.1) |
101 (17.3) |
52 (11.4) |
10 (5.6) |
8 (9.3) |
<0.001 |
23 |
CSF West Nile Virus RT-PCR |
| CSF PCR Ordered Yes, n (%) |
1133 (86.9) |
483 (82.7) |
404 (88.6) |
168 (94.4) |
78 (90.7) |
<0.001 |
24 |
CSF West Nile Virus RT-PCR |
| CSF PCR No Result, n (%) |
38 (2.9) |
20 (3.4) |
13 (2.9) |
3 (1.7) |
2 (2.3) |
0.004 |
26 |
CSF West Nile Virus RT-PCR |
| CSF PCR Positive, n (%) |
4 (0.3) |
3 (0.5) |
1 (0.2) |
0 (0.0) |
0 (0.0) |
0.004 |
27 |
CSF West Nile Virus RT-PCR |
| CSF PCR Negative, n (%) |
1091 (83.7) |
460 (78.8) |
390 (85.5) |
165 (92.7) |
76 (88.4) |
0.004 |
28 |
CSF West Nile Virus RT-PCR |
| CSF PCR Not Ordered, n (%) |
171 (13.1) |
101 (17.3) |
52 (11.4) |
10 (5.6) |
8 (9.3) |
0.004 |
29 |
CSF West Nile Virus RT-PCR |
| CSF Test Ordering |
| PCR Only, n (%) |
951 (72.9) |
369 (63.2) |
361 (79.2) |
150 (84.3) |
71 (82.6) |
<0.001 |
19 |
CSF Test Ordering |
| IgM Only, n (%) |
171 (13.1) |
101 (17.3) |
52 (11.4) |
10 (5.6) |
8 (9.3) |
<0.001 |
20 |
CSF Test Ordering |
| Both PCR & IgM, n (%) |
182 (14.0) |
114 (19.5) |
43 (9.4) |
18 (10.1) |
7 (8.1) |
<0.001 |
21 |
CSF Test Ordering |
| Demographics |
| Male, n (%) |
703 (53.9) |
303 (51.9) |
260 (57.0) |
103 (57.9) |
37 (43.0) |
0.047 |
2 |
Demographics |
| Female, n (%) |
601 (46.1) |
281 (48.1) |
196 (43.0) |
75 (42.1) |
49 (57.0) |
0.047 |
3 |
Demographics |
| Median Age (IQR) |
63.00 [48.00, 73.00] |
62.00 [47.00, 73.73] |
65.00 [50.21, 74.00] |
66.59 [58.10, 73.00] |
43.10 [30.25, 64.00] |
<0.001 |
4 |
Demographics |
| White, n (%) |
994 (76.2) |
435 (74.5) |
334 (73.2) |
158 (88.8) |
67 (77.9) |
0.001 |
6 |
Demographics |
| Non-White, n (%) |
234 (17.9) |
106 (18.2) |
99 (21.7) |
14 (7.9) |
15 (17.4) |
0.001 |
7 |
Demographics |
| Unknown, n (%) |
76 (5.8) |
43 (7.4) |
23 (5.0) |
6 (3.4) |
4 (4.7) |
0.001 |
8 |
Demographics |
| Not Reported Dead, n (%) |
915 (70.2) |
454 (77.7) |
316 (69.3) |
75 (42.1) |
70 (81.4) |
<0.001 |
10 |
Demographics |
| Reported Dead, n (%) |
389 (29.8) |
130 (22.3) |
140 (30.7) |
103 (57.9) |
16 (18.6) |
<0.001 |
11 |
Demographics |
| Other Insurance, n (%) |
933 (71.5) |
430 (73.6) |
295 (64.7) |
145 (81.5) |
63 (73.3) |
<0.001 |
13 |
Demographics |
| Medicaid/Safety Net, n (%) |
371 (28.5) |
154 (26.4) |
161 (35.3) |
33 (18.5) |
23 (26.7) |
<0.001 |
14 |
Demographics |
| Mass General Hospital, n (%) |
706 (54.1) |
350 (59.9) |
256 (56.1) |
44 (24.7) |
56 (65.1) |
<0.001 |
16 |
Demographics |
| Brigham and Women's Hospital, n (%) |
598 (45.9) |
234 (40.1) |
200 (43.9) |
134 (75.3) |
30 (34.9) |
<0.001 |
17 |
Demographics |