| Serum Lab Values |
| Serum WBC (IQR) |
8.17 [5.68, 11.40] |
8.52 [6.55, 11.26] |
7.82 [5.16, 11.45] |
0.001 |
77 |
Serum Lab Values |
| CSF Lab Values |
| CSF Admission Day (IQR) |
1.00 [0.85, 4.00] |
1.00 [0.65, 3.00] |
2.00 [1.00, 5.00] |
<0.001 |
62 |
CSF Lab Values |
| CSF Protein (IQR) |
47.50 [31.70, 78.05] |
51.00 [34.00, 85.17] |
45.00 [30.00, 69.90] |
<0.001 |
63 |
CSF Lab Values |
| CSF Total Protein < 60, n (%) |
834 (64.0) |
347 (59.4) |
487 (67.7) |
0.002 |
65 |
CSF Lab Values |
| CSF Total Protein ≥ 60, n (%) |
469 (36.0) |
237 (40.6) |
232 (32.3) |
0.002 |
66 |
CSF Lab Values |
| CSF Glucose (IQR) |
68.00 [58.00, 85.00] |
68.00 [57.00, 84.25] |
68.00 [59.00, 85.00] |
0.459 |
67 |
CSF Lab Values |
| CSF Total Nucleated Cell Count (IQR) |
3.00 [1.00, 21.00] |
4.00 [1.00, 37.25] |
2.00 [1.00, 11.00] |
<0.001 |
68 |
CSF Lab Values |
| CSF Total Nucleated Cell Count < 5, n (%) |
769 (59.0) |
306 (52.4) |
463 (64.3) |
<0.001 |
70 |
CSF Lab Values |
| CSF Total Nucleated Cell Count ≥ 5, n (%) |
535 (41.0) |
278 (47.6) |
257 (35.7) |
<0.001 |
71 |
CSF Lab Values |
| CSF Lymphocyte Count (IQR) |
66.00 [25.00, 86.00] |
71.00 [34.00, 88.00] |
60.00 [19.00, 84.00] |
<0.001 |
72 |
CSF Lab Values |
| Normal CSF Cell Count (CSF TNC < 5), n (%) |
769 (59.0) |
306 (52.4) |
463 (64.3) |
<0.001 |
74 |
CSF Lab Values |
| Pleocytosis (Lymph ≥ 50%), n (%) |
350 (26.8) |
193 (33.0) |
157 (21.8) |
<0.001 |
75 |
CSF Lab Values |
| Pleocytosis (Lymph < 50%), n (%) |
185 (14.2) |
85 (14.6) |
100 (13.9) |
<0.001 |
76 |
CSF Lab Values |
| Seasonal Testing |
| Test Sent Off-Season, n (%) |
479 (36.7) |
226 (38.7) |
253 (35.1) |
0.205 |
60 |
Seasonal Testing |
| Test Sent June-Nov, n (%) |
825 (63.3) |
358 (61.3) |
467 (64.9) |
0.205 |
61 |
Seasonal Testing |
| Clinical History |
| Immunocompetent, n (%) |
1133 (86.9) |
564 (96.6) |
569 (79.0) |
<0.001 |
51 |
Clinical History |
| Immunosuppressed, n (%) |
171 (13.1) |
20 (3.4) |
151 (21.0) |
<0.001 |
52 |
Clinical History |
| No Transplant, n (%) |
1160 (89.0) |
573 (98.1) |
587 (81.5) |
<0.001 |
54 |
Clinical History |
| History of Transplant, n (%) |
144 (11.0) |
11 (1.9) |
133 (18.5) |
<0.001 |
55 |
Clinical History |
| No B-cell Depleting Meds, n (%) |
1271 (97.5) |
575 (98.5) |
696 (96.7) |
0.061 |
57 |
Clinical History |
| B-cell Depletion, n (%) |
33 (2.5) |
9 (1.5) |
24 (3.3) |
0.061 |
58 |
Clinical History |
| CDC WNV Testing Guideline Adherence |
| Does Not Follow, n (%) |
969 (74.3) |
374 (64.0) |
595 (82.6) |
<0.001 |
47 |
CDC WNV Testing Guideline Adherence |
| Follows, n (%) |
168 (12.9) |
99 (17.0) |
69 (9.6) |
<0.001 |
48 |
CDC WNV Testing Guideline Adherence |
| Follows but Over-Tested, n (%) |
167 (12.8) |
111 (19.0) |
56 (7.8) |
<0.001 |
49 |
CDC WNV Testing Guideline Adherence |
| Serum West Nile Virus IgM |
| Serum IgM Ordered No, n (%) |
1169 (89.6) |
506 (86.6) |
663 (92.1) |
0.002 |
39 |
Serum West Nile Virus IgM |
| Serum IgM Ordered Yes, n (%) |
135 (10.4) |
78 (13.4) |
57 (7.9) |
0.002 |
40 |
Serum West Nile Virus IgM |
| No Result, n (%) |
14 (1.1) |
3 (0.5) |
11 (1.5) |
<0.001 |
42 |
Serum West Nile Virus IgM |
| Positive, n (%) |
11 (0.8) |
4 (0.7) |
7 (1.0) |
<0.001 |
43 |
Serum West Nile Virus IgM |
| Negative, n (%) |
110 (8.4) |
71 (12.2) |
39 (5.4) |
<0.001 |
44 |
Serum West Nile Virus IgM |
| Not Ordered, n (%) |
1169 (89.6) |
506 (86.6) |
663 (92.1) |
<0.001 |
45 |
Serum West Nile Virus IgM |
| CSF West Nile Virus IgM |
| CSF IgM Ordered No, n (%) |
951 (72.9) |
369 (63.2) |
582 (80.8) |
<0.001 |
31 |
CSF West Nile Virus IgM |
| CSF IgM Ordered Yes, n (%) |
353 (27.1) |
215 (36.8) |
138 (19.2) |
<0.001 |
32 |
CSF West Nile Virus IgM |
| CSF IgM No Result, n (%) |
63 (4.8) |
37 (6.3) |
26 (3.6) |
<0.001 |
34 |
CSF West Nile Virus IgM |
| CSF IgM Positive, n (%) |
20 (1.5) |
5 (0.9) |
15 (2.1) |
<0.001 |
35 |
CSF West Nile Virus IgM |
| CSF IgM Negative, n (%) |
270 (20.7) |
173 (29.6) |
97 (13.5) |
<0.001 |
36 |
CSF West Nile Virus IgM |
| CSF IgM Not Ordered, n (%) |
951 (72.9) |
369 (63.2) |
582 (80.8) |
<0.001 |
37 |
CSF West Nile Virus IgM |
| CSF West Nile Virus RT-PCR |
| CSF PCR Ordered No, n (%) |
171 (13.1) |
101 (17.3) |
70 (9.7) |
<0.001 |
23 |
CSF West Nile Virus RT-PCR |
| CSF PCR Ordered Yes, n (%) |
1133 (86.9) |
483 (82.7) |
650 (90.3) |
<0.001 |
24 |
CSF West Nile Virus RT-PCR |
| CSF PCR No Result, n (%) |
38 (2.9) |
20 (3.4) |
18 (2.5) |
<0.001 |
26 |
CSF West Nile Virus RT-PCR |
| CSF PCR Positive, n (%) |
4 (0.3) |
3 (0.5) |
1 (0.1) |
<0.001 |
27 |
CSF West Nile Virus RT-PCR |
| CSF PCR Negative, n (%) |
1091 (83.7) |
460 (78.8) |
631 (87.6) |
<0.001 |
28 |
CSF West Nile Virus RT-PCR |
| CSF PCR Not Ordered, n (%) |
171 (13.1) |
101 (17.3) |
70 (9.7) |
<0.001 |
29 |
CSF West Nile Virus RT-PCR |
| CSF Test Ordering |
| PCR Only, n (%) |
951 (72.9) |
369 (63.2) |
582 (80.8) |
<0.001 |
19 |
CSF Test Ordering |
| IgM Only, n (%) |
171 (13.1) |
101 (17.3) |
70 (9.7) |
<0.001 |
20 |
CSF Test Ordering |
| Both PCR & IgM, n (%) |
182 (14.0) |
114 (19.5) |
68 (9.4) |
<0.001 |
21 |
CSF Test Ordering |
| Demographics |
| Male, n (%) |
703 (53.9) |
303 (51.9) |
400 (55.6) |
0.205 |
2 |
Demographics |
| Female, n (%) |
601 (46.1) |
281 (48.1) |
320 (44.4) |
0.205 |
3 |
Demographics |
| Median Age (IQR) |
63.00 [48.00, 73.00] |
62.00 [47.00, 73.73] |
64.00 [49.00, 73.00] |
0.327 |
4 |
Demographics |
| White, n (%) |
994 (76.2) |
435 (74.5) |
559 (77.6) |
0.094 |
6 |
Demographics |
| Non-White, n (%) |
234 (17.9) |
106 (18.2) |
128 (17.8) |
0.094 |
7 |
Demographics |
| Unknown, n (%) |
76 (5.8) |
43 (7.4) |
33 (4.6) |
0.094 |
8 |
Demographics |
| Not Reported Dead, n (%) |
915 (70.2) |
454 (77.7) |
461 (64.0) |
<0.001 |
10 |
Demographics |
| Reported Dead, n (%) |
389 (29.8) |
130 (22.3) |
259 (36.0) |
<0.001 |
11 |
Demographics |
| Other Insurance, n (%) |
933 (71.5) |
430 (73.6) |
503 (69.9) |
0.150 |
13 |
Demographics |
| Medicaid/Safety Net, n (%) |
371 (28.5) |
154 (26.4) |
217 (30.1) |
0.150 |
14 |
Demographics |
| Mass General Hospital, n (%) |
706 (54.1) |
350 (59.9) |
356 (49.4) |
<0.001 |
16 |
Demographics |
| Brigham and Women's Hospital, n (%) |
598 (45.9) |
234 (40.1) |
364 (50.6) |
<0.001 |
17 |
Demographics |