library(tidyverse)
## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
## ✔ dplyr 1.1.4 ✔ readr 2.1.5
## ✔ forcats 1.0.0 ✔ stringr 1.5.1
## ✔ ggplot2 3.5.2 ✔ tibble 3.2.1
## ✔ lubridate 1.9.4 ✔ tidyr 1.3.1
## ✔ purrr 1.0.4
## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
## ✖ dplyr::filter() masks stats::filter()
## ✖ dplyr::lag() masks stats::lag()
## ℹ Use the conflicted package (<http://conflicted.r-lib.org/>) to force all conflicts to become errors
library(WGCNA)
## Loading required package: dynamicTreeCut
## Loading required package: fastcluster
##
## Attaching package: 'fastcluster'
##
## The following object is masked from 'package:stats':
##
## hclust
##
##
##
## Attaching package: 'WGCNA'
##
## The following object is masked from 'package:stats':
##
## cor
library(conflicted)
options(stringsAsFactors = FALSE)
# Load the gene expression dataset for T2DM-HTN
T2DM_HTNdata <- read.csv("/Users/lorandacalderonzamora/Downloads/datExpr_merge_T2DM-HTN.csv", row.names = NULL)
dim(T2DM_HTNdata)
## [1] 12251 59
names(T2DM_HTNdata)
## [1] "X" "GSM631755" "GSM631756" "GSM631757" "GSM631758" "GSM631759"
## [7] "GSM631760" "GSM631761" "GSM631762" "GSM631763" "GSM631764" "GSM631765"
## [13] "GSM631766" "GSM631767" "GSM524151" "GSM524152" "GSM524153" "GSM524154"
## [19] "GSM524155" "GSM524156" "GSM524157" "GSM524158" "GSM524159" "GSM524160"
## [25] "GSM524161" "GSM524162" "GSM524163" "GSM524164" "GSM524165" "GSM524166"
## [31] "GSM524167" "GSM524168" "GSM524169" "GSM524170" "GSM701161" "GSM701162"
## [37] "GSM701163" "GSM701164" "GSM701165" "GSM701166" "GSM701167" "GSM701168"
## [43] "GSM701169" "GSM701170" "GSM701171" "GSM701173" "GSM701174" "GSM700797"
## [49] "GSM700798" "GSM700799" "GSM700800" "GSM700801" "GSM700802" "GSM700803"
## [55] "GSM609526" "GSM609527" "GSM609528" "GSM609529" "GSM609530"
# Set row names and transposing the Expression matrix
rownames(T2DM_HTNdata) <- T2DM_HTNdata$X
T2DM_HTNdata <- T2DM_HTNdata[, -1]
datExpr <- as.data.frame(t(T2DM_HTNdata))
dim(datExpr)
## [1] 58 12251
# Quality check for genes and samples
gsg = goodSamplesGenes(datExpr, verbose = 3);
## Flagging genes and samples with too many missing values...
## ..step 1
gsg$allOK
## [1] TRUE
# Load the trait metadata associated with the T2DM and HTN samples
sampleTree = hclust(dist(datExpr), method = "average");
sizeGrWindow(12,9)
par(cex = 0.6);
par(mar = c(0,4,2,0))
plot(sampleTree, main = "Sample clustering to detect outliers", sub="", xlab="", cex.lab = 1.5,
cex.axis = 1.5, cex.main = 2)
# Match Expression data with trait metadata
traitData <- read.csv("/Users/lorandacalderonzamora/Downloads/datMeta_merge_T2DM_HTN.csv")
dim(traitData)
## [1] 59 3
names(traitData)
## [1] "geo_accession" "Disease" "Gender"
# Align trait data to match Expression samples
sampleNames <- rownames(datExpr)
head(traitData$geo_accession)
## [1] "GSM631755" "GSM631756" "GSM631757" "GSM631758" "GSM631759" "GSM631760"
all(sampleNames %in% traitData$geo_accession)
## [1] TRUE
# Converte trait variables to numeric format
traitRows <- match(sampleNames, traitData$geo_accession)
datTraits <- traitData[traitRows, ]
rownames(datTraits) <- datTraits$geo_accession
# Sample clustering and visualization of traits as heatmap
datTraits[] <- lapply(datTraits, function(x) {
if (is.character(x) || is.factor(x)) {
as.numeric(as.factor(x))
} else {
x
}
})
datTraits_clean <- datTraits[, sapply(datTraits, is.numeric)]
str(datTraits_clean)
## 'data.frame': 58 obs. of 3 variables:
## $ geo_accession: num 26 27 28 29 30 31 32 33 34 35 ...
## $ Disease : num 1 1 1 1 1 1 1 3 3 3 ...
## $ Gender : num 2 2 2 2 1 1 1 2 2 1 ...
sampleTree2 <- hclust(dist(datExpr), method = "average")
traitColors <- numbers2colors(datTraits_clean, signed = FALSE)
plotDendroAndColors(sampleTree2, traitColors,
groupLabels = names(datTraits_clean),
main = "Sample dendrogram and trait heatmap")
save(datExpr, datTraits_clean, file = "T2DM_HTNdataInput.RData")
lnames = load(file = "T2DM_HTNdataInput.RData");
#The variable lnames contains the names of loaded variables.
lnames
## [1] "datExpr" "datTraits_clean"
# Filter the least variable genes (optional)
variance_genes <- apply(datExpr, 2, var)
datExpr_filtered <- datExpr[, variance_genes > quantile(variance_genes, 0.70)]
# Select a range of soft-thresholding powers
powers = c(1:10)
sft = pickSoftThreshold(datExpr_filtered, powerVector = powers, verbose = 5)
## pickSoftThreshold: will use block size 3675.
## pickSoftThreshold: calculating connectivity for given powers...
## ..working on genes 1 through 3675 of 3675
## Warning: executing %dopar% sequentially: no parallel backend registered
## Power SFT.R.sq slope truncated.R.sq mean.k. median.k. max.k.
## 1 1 0.435 1.850 0.884 1240.0 1260.00 1840.0
## 2 2 0.016 0.192 0.789 563.0 565.00 1080.0
## 3 3 0.130 -0.511 0.848 294.0 286.00 697.0
## 4 4 0.374 -0.951 0.919 167.0 156.00 475.0
## 5 5 0.516 -1.260 0.948 101.0 90.40 337.0
## 6 6 0.616 -1.520 0.969 63.4 54.30 249.0
## 7 7 0.675 -1.730 0.978 41.4 33.90 187.0
## 8 8 0.710 -1.920 0.983 27.7 21.70 143.0
## 9 9 0.751 -1.990 0.991 19.1 14.20 111.0
## 10 10 0.781 -2.060 0.994 13.4 9.45 87.2
sizeGrWindow(9, 5)
par(mfrow = c(1, 2))
cex1 = 0.9
plot(sft$fitIndices[,1], -sign(sft$fitIndices[,3]) * sft$fitIndices[,2],
xlab = "Soft Threshold (power)",
ylab = "Scale Free Topology Model Fit, signed R^2", type = "n",
main = "Scale independence")
text(sft$fitIndices[,1], -sign(sft$fitIndices[,3]) * sft$fitIndices[,2],
labels = powers, cex = cex1, col = "red")
abline(h = 0.80, col = "red") # Ajuste del umbral a 0.80
plot(sft$fitIndices[,1], sft$fitIndices[,5],
xlab = "Soft Threshold (power)",
ylab = "Mean Connectivity", type = "n",
main = "Mean connectivity")
text(sft$fitIndices[,1], sft$fitIndices[,5], labels = powers, cex = cex1, col = "red")
net = blockwiseModules(
datExpr,
power = 10,
TOMType = "unsigned",
minModuleSize = 200,
reassignThreshold = 0,
mergeCutHeight = 0.25,
numericLabels = TRUE,
pamRespectsDendro = FALSE,
saveTOMs = TRUE,
saveTOMFileBase = "TOM_T2DM-HTN",
verbose = 3
)
## Calculating module eigengenes block-wise from all genes
## Flagging genes and samples with too many missing values...
## ..step 1
## ....pre-clustering genes to determine blocks..
## Projective K-means:
## ..k-means clustering..
## ..merging smaller clusters...
## Block sizes:
## gBlocks
## 1 2 3
## 4705 4039 3507
## ..Working on block 1 .
## TOM calculation: adjacency..
## ..will not use multithreading.
## Fraction of slow calculations: 0.000000
## ..connectivity..
## ..matrix multiplication (system BLAS)..
## ..normalization..
## ..done.
## ..saving TOM for block 1 into file TOM_T2DM-HTN-block.1.RData
## ....clustering..
## ....detecting modules..
## ....calculating module eigengenes..
## ....checking kME in modules..
## ..removing 1 genes from module 1 because their KME is too low.
## ..removing 1 genes from module 2 because their KME is too low.
## ..removing 1 genes from module 4 because their KME is too low.
## ..Working on block 2 .
## TOM calculation: adjacency..
## ..will not use multithreading.
## Fraction of slow calculations: 0.000000
## ..connectivity..
## ..matrix multiplication (system BLAS)..
## ..normalization..
## ..done.
## ..saving TOM for block 2 into file TOM_T2DM-HTN-block.2.RData
## ....clustering..
## ....detecting modules..
## ....calculating module eigengenes..
## ....checking kME in modules..
## ..removing 1 genes from module 1 because their KME is too low.
## ..Working on block 3 .
## TOM calculation: adjacency..
## ..will not use multithreading.
## Fraction of slow calculations: 0.000000
## ..connectivity..
## ..matrix multiplication (system BLAS)..
## ..normalization..
## ..done.
## ..saving TOM for block 3 into file TOM_T2DM-HTN-block.3.RData
## ....clustering..
## ....detecting modules..
## ....calculating module eigengenes..
## ....checking kME in modules..
## ..removing 1 genes from module 1 because their KME is too low.
## ..merging modules that are too close..
## mergeCloseModules: Merging modules whose distance is less than 0.25
## Calculating new MEs...
sizeGrWindow(12, 9)
mergedColors = labels2colors(net$colors)
for (i in 1:length(net$dendrograms)) {
plotDendroAndColors(
net$dendrograms[[i]],
mergedColors[net$blockGenes[[i]]],
"Module colors",
dendroLabels = FALSE,
hang = 0.03,
addGuide = TRUE, guideHang = 0.05
)
}
table(net$colors) # Gene counts per module
##
## 0 1 2 3 4 5 6 7 8 9
## 2139 2486 1607 1495 1447 1128 690 508 471 280
MEs = net$MEs # # Module Eigengene
moduleTraitCor = cor(MEs, datTraits_clean, use = "pairwise.complete.obs")
moduleTraitPvalue = corPvalueStudent(moduleTraitCor, nrow(datExpr))
print(moduleTraitCor)
## geo_accession Disease Gender
## ME1 0.19500519 0.35521308 -0.208789611
## ME6 0.54697658 0.35167365 0.001709643
## ME8 0.43806977 0.32061379 0.029701219
## ME4 -0.27348467 -0.26427643 0.131830993
## ME3 -0.18066237 0.06509473 0.039415092
## ME9 0.03527569 0.02334533 0.110321169
## ME2 -0.46755929 0.01983564 -0.162029221
## ME5 -0.51000297 -0.46297316 0.049633156
## ME7 -0.29600439 -0.49773354 0.031914095
## ME0 0.43096154 0.21011564 0.097884182
print(moduleTraitPvalue)
## geo_accession Disease Gender
## ME1 1.424005e-01 6.215578e-03 0.1157489
## ME6 8.887300e-06 6.788873e-03 0.9898378
## ME8 5.834420e-04 1.413857e-02 0.8248413
## ME4 3.777943e-02 4.500029e-02 0.3239108
## ME3 1.747401e-01 6.273428e-01 0.7689443
## ME9 7.926391e-01 8.619079e-01 0.4097055
## ME2 2.151409e-04 8.825087e-01 0.2243033
## ME5 4.324168e-05 2.527554e-04 0.7113865
## ME7 2.406766e-02 7.028047e-05 0.8120206
## ME0 7.323545e-04 1.134015e-01 0.4647828
# Extract the correlations and p-values for the trait "Disease"
cor_Disease = moduleTraitCor[, "Disease"]
pval_Disease = moduleTraitPvalue[, "Disease"]
best_module = which.max(abs(cor_Disease))
print(paste("Most significant module:", names(cor_Disease)[best_module]))
## [1] "Most significant module: ME7"
print(paste("Correlation:", cor_Disease[best_module]))
## [1] "Correlation: -0.497733540290387"
print(paste("P-value:", pval_Disease[best_module]))
## [1] "P-value: 7.02804651992773e-05"
module7_genes = names(datExpr)[net$colors == 7]
head(module7_genes)
## [1] "ENSG00000005206" "ENSG00000005893" "ENSG00000006377" "ENSG00000006576"
## [5] "ENSG00000007168" "ENSG00000007384"
str(module7_genes)
## chr [1:508] "ENSG00000005206" "ENSG00000005893" "ENSG00000006377" ...
# PPI network analysis
library(STRINGdb)
string_db <- STRINGdb$new(version = "11.5", species = 9606,
score_threshold = 400, input_directory = "")
# Mapping Module ME7 and visualizing Protein-Protein Interaction Network
module7_genes <- gsub("\\..*", "", module7_genes)
df_genes <- data.frame(ENSEMBL = module7_genes)
mapped_genes <- string_db$map(df_genes, "ENSEMBL", removeUnmappedRows = TRUE)
## Warning: we couldn't map to STRING 6% of your identifiers
print(head(mapped_genes))
## ENSEMBL STRING_id
## 1 ENSG00000005206 9606.ENSP00000478298
## 2 ENSG00000005893 9606.ENSP00000408411
## 3 ENSG00000006377 9606.ENSP00000428480
## 4 ENSG00000006576 9606.ENSP00000403042
## 5 ENSG00000007168 9606.ENSP00000380378
## 6 ENSG00000007384 9606.ENSP00000262316
unmapped_genes <- setdiff(df_genes$ENSEMBL, mapped_genes$ENSEMBL)
print(unmapped_genes)
## [1] "ENSG00000088340" "ENSG00000102055" "ENSG00000180581" "ENSG00000182841"
## [5] "ENSG00000184566" "ENSG00000220541" "ENSG00000231313" "ENSG00000231543"
## [9] "ENSG00000231989" "ENSG00000234801" "ENSG00000255872" "ENSG00000256646"
## [13] "ENSG00000262943" "ENSG00000264324" "ENSG00000275272" "ENSG00000276371"
## [17] "ENSG00000276463" "ENSG00000276725" "ENSG00000280549" "ENSG00000281320"
## [21] "ENSG00000281879" "ENSG00000282367" "ENSG00000282902" "ENSG00000282958"
## [25] "ENSG00000286001" "ENSG00000288269" "ENSG00000288368" "ENSG00000288453"
## [29] "ENSG00000291701" "ENSG00000291929" "ENSG00000292002" "ENSG00000292366"
## [33] "ENSG00000298169"
string_db$plot_network(mapped_genes$STRING_id)
interactions <- string_db$get_interactions(mapped_genes$STRING_id)
head(interactions)
## from to combined_score
## 1 9606.ENSP00000210313 9606.ENSP00000216455 988
## 2 9606.ENSP00000210313 9606.ENSP00000216455 988
## 3 9606.ENSP00000216330 9606.ENSP00000216455 770
## 4 9606.ENSP00000216330 9606.ENSP00000216455 770
## 5 9606.ENSP00000210313 9606.ENSP00000217958 972
## 6 9606.ENSP00000210313 9606.ENSP00000217958 972
# Functional enrichment analysis
enrichment_results_GO <- string_db$get_enrichment(
string_ids = mapped_genes$STRING_id,
category = "Process", # GO "Process" or "Pathway" by KEGG
methodMT = "fdr",
iea = FALSE
)
## Warning in string_db$get_enrichment(string_ids = mapped_genes$STRING_id, :
## methodMT parameter is depecated. Only FDR correction is available.
## Warning in string_db$get_enrichment(string_ids = mapped_genes$STRING_id, : iea
## parameter is deprecated.
head(enrichment_results_GO)
## category term number_of_genes number_of_genes_in_background
## 36 Process GO:0044237 259 7513
## 37 Process GO:0043170 220 6137
## 38 Process GO:0071704 260 7755
## 39 Process GO:0008152 272 8298
## 40 Process GO:0044238 247 7332
## 41 Process GO:0006807 234 6852
## ncbiTaxonId
## 36 9606
## 37 9606
## 38 9606
## 39 9606
## 40 9606
## 41 9606
## inputGenes
## 36 9606.ENSP00000188790,9606.ENSP00000196061,9606.ENSP00000200181,9606.ENSP00000200676,9606.ENSP00000210313,9606.ENSP00000216330,9606.ENSP00000216452,9606.ENSP00000216455,9606.ENSP00000216554,9606.ENSP00000216832,9606.ENSP00000216962,9606.ENSP00000217958,9606.ENSP00000221138,9606.ENSP00000221730,9606.ENSP00000223127,9606.ENSP00000225298,9606.ENSP00000225719,9606.ENSP00000227667,9606.ENSP00000230085,9606.ENSP00000234420,9606.ENSP00000237455,9606.ENSP00000239231,9606.ENSP00000239891,9606.ENSP00000241052,9606.ENSP00000242719,9606.ENSP00000244227,9606.ENSP00000248594,9606.ENSP00000249299,9606.ENSP00000252590,9606.ENSP00000252723,9606.ENSP00000252826,9606.ENSP00000253099,9606.ENSP00000254193,9606.ENSP00000254719,9606.ENSP00000256078,9606.ENSP00000256151,9606.ENSP00000258169,9606.ENSP00000258428,9606.ENSP00000258772,9606.ENSP00000259050,9606.ENSP00000259605,9606.ENSP00000260443,9606.ENSP00000260508,9606.ENSP00000260810,9606.ENSP00000261483,9606.ENSP00000261593,9606.ENSP00000261721,9606.ENSP00000262160,9606.ENSP00000262460,9606.ENSP00000262554,9606.ENSP00000263383,9606.ENSP00000263960,9606.ENSP00000264005,9606.ENSP00000264156,9606.ENSP00000264193,9606.ENSP00000264389,9606.ENSP00000265000,9606.ENSP00000268717,9606.ENSP00000268896,9606.ENSP00000269228,9606.ENSP00000269571,9606.ENSP00000271308,9606.ENSP00000271620,9606.ENSP00000272067,9606.ENSP00000274376,9606.ENSP00000282516,9606.ENSP00000283875,9606.ENSP00000287490,9606.ENSP00000288774,9606.ENSP00000289119,9606.ENSP00000290277,9606.ENSP00000295899,9606.ENSP00000296088,9606.ENSP00000296099,9606.ENSP00000296456,9606.ENSP00000296503,9606.ENSP00000296564,9606.ENSP00000296870,9606.ENSP00000297689,9606.ENSP00000299155,9606.ENSP00000300413,9606.ENSP00000300688,9606.ENSP00000301012,9606.ENSP00000301178,9606.ENSP00000301396,9606.ENSP00000301607,9606.ENSP00000302160,9606.ENSP00000302234,9606.ENSP00000303754,9606.ENSP00000306010,9606.ENSP00000306528,9606.ENSP00000306548,9606.ENSP00000307298,9606.ENSP00000309141,9606.ENSP00000310623,9606.ENSP00000310661,9606.ENSP00000310861,9606.ENSP00000311032,9606.ENSP00000315791,9606.ENSP00000316244,9606.ENSP00000318480,9606.ENSP00000318635,9606.ENSP00000319756,9606.ENSP00000321070,9606.ENSP00000323424,9606.ENSP00000325425,9606.ENSP00000325612,9606.ENSP00000326261,9606.ENSP00000326272,9606.ENSP00000328875,9606.ENSP00000331201,9606.ENSP00000331310,9606.ENSP00000337180,9606.ENSP00000338345,9606.ENSP00000338673,9606.ENSP00000339495,9606.ENSP00000340361,9606.ENSP00000341361,9606.ENSP00000341779,9606.ENSP00000342105,9606.ENSP00000345195,9606.ENSP00000345270,9606.ENSP00000345793,9606.ENSP00000345853,9606.ENSP00000346300,9606.ENSP00000349437,9606.ENSP00000349543,9606.ENSP00000350708,9606.ENSP00000351697,9606.ENSP00000351789,9606.ENSP00000351990,9606.ENSP00000352414,9606.ENSP00000353741,9606.ENSP00000354340,9606.ENSP00000354633,9606.ENSP00000355014,9606.ENSP00000355231,9606.ENSP00000355566,9606.ENSP00000355651,9606.ENSP00000355889,9606.ENSP00000356438,9606.ENSP00000357259,9606.ENSP00000357304,9606.ENSP00000357928,9606.ENSP00000358072,9606.ENSP00000358335,9606.ENSP00000358695,9606.ENSP00000358737,9606.ENSP00000359132,9606.ENSP00000359295,9606.ENSP00000359506,9606.ENSP00000359609,9606.ENSP00000359956,9606.ENSP00000360525,9606.ENSP00000360613,9606.ENSP00000360939,9606.ENSP00000361366,9606.ENSP00000361658,9606.ENSP00000361777,9606.ENSP00000361918,9606.ENSP00000361927,9606.ENSP00000362299,9606.ENSP00000362387,9606.ENSP00000363019,9606.ENSP00000365312,9606.ENSP00000365950,9606.ENSP00000367203,9606.ENSP00000367440,9606.ENSP00000367608,9606.ENSP00000367623,9606.ENSP00000367697,9606.ENSP00000368190,9606.ENSP00000368356,9606.ENSP00000368884,9606.ENSP00000369375,9606.ENSP00000369391,9606.ENSP00000369530,9606.ENSP00000370376,9606.ENSP00000371000,9606.ENSP00000371554,9606.ENSP00000373713,9606.ENSP00000374354,9606.ENSP00000375942,9606.ENSP00000376142,9606.ENSP00000376611,9606.ENSP00000377867,9606.ENSP00000378323,9606.ENSP00000378332,9606.ENSP00000378405,9606.ENSP00000378725,9606.ENSP00000379042,9606.ENSP00000379372,9606.ENSP00000380378,9606.ENSP00000380793,9606.ENSP00000381340,9606.ENSP00000381717,9606.ENSP00000382177,9606.ENSP00000382805,9606.ENSP00000384004,9606.ENSP00000384109,9606.ENSP00000385610,9606.ENSP00000385751,9606.ENSP00000386134,9606.ENSP00000386660,9606.ENSP00000387050,9606.ENSP00000387362,9606.ENSP00000387699,9606.ENSP00000388325,9606.ENSP00000389813,9606.ENSP00000392028,9606.ENSP00000392270,9606.ENSP00000400591,9606.ENSP00000403397,9606.ENSP00000404381,9606.ENSP00000406598,9606.ENSP00000408002,9606.ENSP00000408411,9606.ENSP00000408526,9606.ENSP00000408860,9606.ENSP00000409131,9606.ENSP00000410758,9606.ENSP00000410833,9606.ENSP00000411099,9606.ENSP00000415151,9606.ENSP00000416534,9606.ENSP00000417138,9606.ENSP00000417185,9606.ENSP00000417686,9606.ENSP00000418008,9606.ENSP00000418563,9606.ENSP00000418910,9606.ENSP00000419045,9606.ENSP00000420037,9606.ENSP00000420195,9606.ENSP00000422392,9606.ENSP00000428085,9606.ENSP00000428209,9606.ENSP00000428223,9606.ENSP00000430338,9606.ENSP00000436047,9606.ENSP00000438144,9606.ENSP00000438689,9606.ENSP00000438788,9606.ENSP00000444029,9606.ENSP00000445359,9606.ENSP00000448998,9606.ENSP00000451000,9606.ENSP00000452697,9606.ENSP00000461749,9606.ENSP00000462963,9606.ENSP00000463058,9606.ENSP00000463650,9606.ENSP00000465759,9606.ENSP00000472998,9606.ENSP00000478310,9606.ENSP00000479953,9606.ENSP00000480186,9606.ENSP00000480476,9606.ENSP00000482504
## 37 9606.ENSP00000188790,9606.ENSP00000196061,9606.ENSP00000210313,9606.ENSP00000216330,9606.ENSP00000216452,9606.ENSP00000216455,9606.ENSP00000216554,9606.ENSP00000216832,9606.ENSP00000216962,9606.ENSP00000217958,9606.ENSP00000221138,9606.ENSP00000223127,9606.ENSP00000225298,9606.ENSP00000225719,9606.ENSP00000227667,9606.ENSP00000230085,9606.ENSP00000234420,9606.ENSP00000237455,9606.ENSP00000239891,9606.ENSP00000241052,9606.ENSP00000242719,9606.ENSP00000244227,9606.ENSP00000248594,9606.ENSP00000249299,9606.ENSP00000252590,9606.ENSP00000252723,9606.ENSP00000252826,9606.ENSP00000253099,9606.ENSP00000254193,9606.ENSP00000254719,9606.ENSP00000256078,9606.ENSP00000256151,9606.ENSP00000258169,9606.ENSP00000258428,9606.ENSP00000258772,9606.ENSP00000259050,9606.ENSP00000259605,9606.ENSP00000260443,9606.ENSP00000260810,9606.ENSP00000261483,9606.ENSP00000261593,9606.ENSP00000261721,9606.ENSP00000262160,9606.ENSP00000262316,9606.ENSP00000262460,9606.ENSP00000264005,9606.ENSP00000264156,9606.ENSP00000264389,9606.ENSP00000265000,9606.ENSP00000268717,9606.ENSP00000269228,9606.ENSP00000269571,9606.ENSP00000271308,9606.ENSP00000272067,9606.ENSP00000274376,9606.ENSP00000282516,9606.ENSP00000283875,9606.ENSP00000288774,9606.ENSP00000290277,9606.ENSP00000295899,9606.ENSP00000296088,9606.ENSP00000296456,9606.ENSP00000296503,9606.ENSP00000296564,9606.ENSP00000296870,9606.ENSP00000297689,9606.ENSP00000300413,9606.ENSP00000301012,9606.ENSP00000301178,9606.ENSP00000301396,9606.ENSP00000301607,9606.ENSP00000302160,9606.ENSP00000302234,9606.ENSP00000303754,9606.ENSP00000306010,9606.ENSP00000306528,9606.ENSP00000306548,9606.ENSP00000307298,9606.ENSP00000309141,9606.ENSP00000310861,9606.ENSP00000311032,9606.ENSP00000313875,9606.ENSP00000315791,9606.ENSP00000318480,9606.ENSP00000318635,9606.ENSP00000319756,9606.ENSP00000323424,9606.ENSP00000325612,9606.ENSP00000326261,9606.ENSP00000326272,9606.ENSP00000328875,9606.ENSP00000331201,9606.ENSP00000331310,9606.ENSP00000338345,9606.ENSP00000338673,9606.ENSP00000339495,9606.ENSP00000340361,9606.ENSP00000341361,9606.ENSP00000341779,9606.ENSP00000342105,9606.ENSP00000345195,9606.ENSP00000345270,9606.ENSP00000345793,9606.ENSP00000345853,9606.ENSP00000346300,9606.ENSP00000349437,9606.ENSP00000349543,9606.ENSP00000350708,9606.ENSP00000351697,9606.ENSP00000351789,9606.ENSP00000351990,9606.ENSP00000352414,9606.ENSP00000353741,9606.ENSP00000354340,9606.ENSP00000354633,9606.ENSP00000355014,9606.ENSP00000355231,9606.ENSP00000355566,9606.ENSP00000355889,9606.ENSP00000356438,9606.ENSP00000357259,9606.ENSP00000357304,9606.ENSP00000357928,9606.ENSP00000358072,9606.ENSP00000358335,9606.ENSP00000359132,9606.ENSP00000359295,9606.ENSP00000359506,9606.ENSP00000360525,9606.ENSP00000360613,9606.ENSP00000361366,9606.ENSP00000361658,9606.ENSP00000361777,9606.ENSP00000361918,9606.ENSP00000361927,9606.ENSP00000362299,9606.ENSP00000362387,9606.ENSP00000363019,9606.ENSP00000365312,9606.ENSP00000365950,9606.ENSP00000367203,9606.ENSP00000367440,9606.ENSP00000367623,9606.ENSP00000367697,9606.ENSP00000368190,9606.ENSP00000368356,9606.ENSP00000368884,9606.ENSP00000369375,9606.ENSP00000369391,9606.ENSP00000370376,9606.ENSP00000371000,9606.ENSP00000374354,9606.ENSP00000375942,9606.ENSP00000376611,9606.ENSP00000377867,9606.ENSP00000378323,9606.ENSP00000378332,9606.ENSP00000378405,9606.ENSP00000378504,9606.ENSP00000378725,9606.ENSP00000379042,9606.ENSP00000379372,9606.ENSP00000380793,9606.ENSP00000381340,9606.ENSP00000381717,9606.ENSP00000382805,9606.ENSP00000384004,9606.ENSP00000384109,9606.ENSP00000385610,9606.ENSP00000385751,9606.ENSP00000386134,9606.ENSP00000386660,9606.ENSP00000387050,9606.ENSP00000387362,9606.ENSP00000387699,9606.ENSP00000388325,9606.ENSP00000392028,9606.ENSP00000392270,9606.ENSP00000400591,9606.ENSP00000403397,9606.ENSP00000404381,9606.ENSP00000406598,9606.ENSP00000408002,9606.ENSP00000408411,9606.ENSP00000409131,9606.ENSP00000410758,9606.ENSP00000410833,9606.ENSP00000411099,9606.ENSP00000415151,9606.ENSP00000416534,9606.ENSP00000417185,9606.ENSP00000417686,9606.ENSP00000418008,9606.ENSP00000418563,9606.ENSP00000418910,9606.ENSP00000420037,9606.ENSP00000420195,9606.ENSP00000422392,9606.ENSP00000428085,9606.ENSP00000428209,9606.ENSP00000428223,9606.ENSP00000430338,9606.ENSP00000436047,9606.ENSP00000438788,9606.ENSP00000444029,9606.ENSP00000451000,9606.ENSP00000452697,9606.ENSP00000461749,9606.ENSP00000462963,9606.ENSP00000463058,9606.ENSP00000463650,9606.ENSP00000465759,9606.ENSP00000470555,9606.ENSP00000472998,9606.ENSP00000478298,9606.ENSP00000478310,9606.ENSP00000479953,9606.ENSP00000480186,9606.ENSP00000482504,9606.ENSP00000484411
## 38 9606.ENSP00000188790,9606.ENSP00000196061,9606.ENSP00000200676,9606.ENSP00000210313,9606.ENSP00000216330,9606.ENSP00000216452,9606.ENSP00000216455,9606.ENSP00000216554,9606.ENSP00000216832,9606.ENSP00000216962,9606.ENSP00000217958,9606.ENSP00000221138,9606.ENSP00000221730,9606.ENSP00000223127,9606.ENSP00000225298,9606.ENSP00000225719,9606.ENSP00000227667,9606.ENSP00000230085,9606.ENSP00000234420,9606.ENSP00000237455,9606.ENSP00000239231,9606.ENSP00000239891,9606.ENSP00000241052,9606.ENSP00000242719,9606.ENSP00000244227,9606.ENSP00000248594,9606.ENSP00000249299,9606.ENSP00000252590,9606.ENSP00000252723,9606.ENSP00000252826,9606.ENSP00000253099,9606.ENSP00000254193,9606.ENSP00000254719,9606.ENSP00000256078,9606.ENSP00000256151,9606.ENSP00000258169,9606.ENSP00000258428,9606.ENSP00000258772,9606.ENSP00000259050,9606.ENSP00000259605,9606.ENSP00000260443,9606.ENSP00000260508,9606.ENSP00000260810,9606.ENSP00000261483,9606.ENSP00000261593,9606.ENSP00000261721,9606.ENSP00000262160,9606.ENSP00000262316,9606.ENSP00000262460,9606.ENSP00000262554,9606.ENSP00000263383,9606.ENSP00000263960,9606.ENSP00000264005,9606.ENSP00000264156,9606.ENSP00000264193,9606.ENSP00000264389,9606.ENSP00000265000,9606.ENSP00000268717,9606.ENSP00000268896,9606.ENSP00000269228,9606.ENSP00000269571,9606.ENSP00000271308,9606.ENSP00000271620,9606.ENSP00000272067,9606.ENSP00000274376,9606.ENSP00000282516,9606.ENSP00000283875,9606.ENSP00000288774,9606.ENSP00000289119,9606.ENSP00000290277,9606.ENSP00000295899,9606.ENSP00000296088,9606.ENSP00000296456,9606.ENSP00000296503,9606.ENSP00000296564,9606.ENSP00000296870,9606.ENSP00000297689,9606.ENSP00000299155,9606.ENSP00000300413,9606.ENSP00000300688,9606.ENSP00000301012,9606.ENSP00000301178,9606.ENSP00000301396,9606.ENSP00000301607,9606.ENSP00000302160,9606.ENSP00000302234,9606.ENSP00000303754,9606.ENSP00000306010,9606.ENSP00000306528,9606.ENSP00000306548,9606.ENSP00000307298,9606.ENSP00000309141,9606.ENSP00000310661,9606.ENSP00000310861,9606.ENSP00000311032,9606.ENSP00000313875,9606.ENSP00000315791,9606.ENSP00000316244,9606.ENSP00000316786,9606.ENSP00000318480,9606.ENSP00000318635,9606.ENSP00000319756,9606.ENSP00000321070,9606.ENSP00000323424,9606.ENSP00000325425,9606.ENSP00000325612,9606.ENSP00000326261,9606.ENSP00000326272,9606.ENSP00000328875,9606.ENSP00000331201,9606.ENSP00000331310,9606.ENSP00000337180,9606.ENSP00000338345,9606.ENSP00000338673,9606.ENSP00000339495,9606.ENSP00000340361,9606.ENSP00000341361,9606.ENSP00000341779,9606.ENSP00000342105,9606.ENSP00000345195,9606.ENSP00000345270,9606.ENSP00000345793,9606.ENSP00000345853,9606.ENSP00000346300,9606.ENSP00000349437,9606.ENSP00000349543,9606.ENSP00000350708,9606.ENSP00000351697,9606.ENSP00000351789,9606.ENSP00000351990,9606.ENSP00000352414,9606.ENSP00000353741,9606.ENSP00000354340,9606.ENSP00000354476,9606.ENSP00000354633,9606.ENSP00000355014,9606.ENSP00000355231,9606.ENSP00000355566,9606.ENSP00000355651,9606.ENSP00000355889,9606.ENSP00000356438,9606.ENSP00000357259,9606.ENSP00000357304,9606.ENSP00000357928,9606.ENSP00000358072,9606.ENSP00000358335,9606.ENSP00000358737,9606.ENSP00000359132,9606.ENSP00000359295,9606.ENSP00000359506,9606.ENSP00000359609,9606.ENSP00000359956,9606.ENSP00000360525,9606.ENSP00000360613,9606.ENSP00000360939,9606.ENSP00000361366,9606.ENSP00000361658,9606.ENSP00000361777,9606.ENSP00000361918,9606.ENSP00000361927,9606.ENSP00000362299,9606.ENSP00000362387,9606.ENSP00000363019,9606.ENSP00000365312,9606.ENSP00000365950,9606.ENSP00000367203,9606.ENSP00000367440,9606.ENSP00000367623,9606.ENSP00000367697,9606.ENSP00000368190,9606.ENSP00000368356,9606.ENSP00000368884,9606.ENSP00000369375,9606.ENSP00000369391,9606.ENSP00000369530,9606.ENSP00000370376,9606.ENSP00000371000,9606.ENSP00000373713,9606.ENSP00000374354,9606.ENSP00000375942,9606.ENSP00000376142,9606.ENSP00000376611,9606.ENSP00000377867,9606.ENSP00000378323,9606.ENSP00000378332,9606.ENSP00000378405,9606.ENSP00000378504,9606.ENSP00000378725,9606.ENSP00000379042,9606.ENSP00000379372,9606.ENSP00000380378,9606.ENSP00000380793,9606.ENSP00000381340,9606.ENSP00000381717,9606.ENSP00000382177,9606.ENSP00000382805,9606.ENSP00000384004,9606.ENSP00000384109,9606.ENSP00000385610,9606.ENSP00000385751,9606.ENSP00000386134,9606.ENSP00000386660,9606.ENSP00000387050,9606.ENSP00000387362,9606.ENSP00000387699,9606.ENSP00000388325,9606.ENSP00000389813,9606.ENSP00000392028,9606.ENSP00000392270,9606.ENSP00000400591,9606.ENSP00000403397,9606.ENSP00000404381,9606.ENSP00000406598,9606.ENSP00000408002,9606.ENSP00000408411,9606.ENSP00000408526,9606.ENSP00000408860,9606.ENSP00000409131,9606.ENSP00000410758,9606.ENSP00000410833,9606.ENSP00000411099,9606.ENSP00000415151,9606.ENSP00000416534,9606.ENSP00000417138,9606.ENSP00000417185,9606.ENSP00000417686,9606.ENSP00000418008,9606.ENSP00000418563,9606.ENSP00000418910,9606.ENSP00000419045,9606.ENSP00000420037,9606.ENSP00000420195,9606.ENSP00000422392,9606.ENSP00000428085,9606.ENSP00000428209,9606.ENSP00000428223,9606.ENSP00000430338,9606.ENSP00000436047,96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## 39 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## 40 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## 41 9606.ENSP00000188790,9606.ENSP00000196061,9606.ENSP00000200676,9606.ENSP00000210313,9606.ENSP00000216330,9606.ENSP00000216452,9606.ENSP00000216455,9606.ENSP00000216554,9606.ENSP00000216832,9606.ENSP00000217958,9606.ENSP00000221138,9606.ENSP00000223127,9606.ENSP00000225298,9606.ENSP00000225719,9606.ENSP00000227667,9606.ENSP00000230085,9606.ENSP00000234420,9606.ENSP00000237455,9606.ENSP00000239231,9606.ENSP00000239891,9606.ENSP00000241052,9606.ENSP00000242719,9606.ENSP00000244227,9606.ENSP00000248594,9606.ENSP00000249299,9606.ENSP00000252590,9606.ENSP00000252723,9606.ENSP00000252826,9606.ENSP00000253099,9606.ENSP00000254193,9606.ENSP00000254719,9606.ENSP00000256078,9606.ENSP00000256151,9606.ENSP00000258169,9606.ENSP00000258428,9606.ENSP00000258772,9606.ENSP00000259050,9606.ENSP00000259605,9606.ENSP00000260443,9606.ENSP00000260508,9606.ENSP00000260810,9606.ENSP00000261483,9606.ENSP00000261593,9606.ENSP00000261721,9606.ENSP00000262160,9606.ENSP00000262316,9606.ENSP00000262460,9606.ENSP00000262554,9606.ENSP00000264005,9606.ENSP00000264156,9606.ENSP00000264193,9606.ENSP00000264389,9606.ENSP00000265000,9606.ENSP00000268717,9606.ENSP00000268896,9606.ENSP00000269228,9606.ENSP00000269571,9606.ENSP00000271308,9606.ENSP00000272067,9606.ENSP00000274376,9606.ENSP00000282516,9606.ENSP00000283875,9606.ENSP00000288774,9606.ENSP00000289119,9606.ENSP00000290277,9606.ENSP00000295899,9606.ENSP00000296088,9606.ENSP00000296456,9606.ENSP00000296503,9606.ENSP00000296564,9606.ENSP00000296870,9606.ENSP00000297689,9606.ENSP00000299155,9606.ENSP00000300413,9606.ENSP00000300688,9606.ENSP00000301012,9606.ENSP00000301178,9606.ENSP00000301396,9606.ENSP00000301607,9606.ENSP00000302160,9606.ENSP00000302234,9606.ENSP00000303754,9606.ENSP00000306010,9606.ENSP00000306528,9606.ENSP00000306548,9606.ENSP00000307298,9606.ENSP00000309141,9606.ENSP00000310661,9606.ENSP00000310861,9606.ENSP00000311032,9606.ENSP00000315791,9606.ENSP00000316244,9606.ENSP00000318480,9606.ENSP00000318635,9606.ENSP00000319756,9606.ENSP00000323424,9606.ENSP00000325612,9606.ENSP00000326261,9606.ENSP00000326272,9606.ENSP00000328875,9606.ENSP00000331201,9606.ENSP00000331310,9606.ENSP00000337180,9606.ENSP00000338345,9606.ENSP00000338673,9606.ENSP00000339495,9606.ENSP00000340361,9606.ENSP00000341361,9606.ENSP00000341779,9606.ENSP00000342105,9606.ENSP00000345195,9606.ENSP00000345270,9606.ENSP00000345793,9606.ENSP00000345853,9606.ENSP00000346300,9606.ENSP00000349437,9606.ENSP00000349543,9606.ENSP00000350708,9606.ENSP00000351697,9606.ENSP00000351789,9606.ENSP00000351990,9606.ENSP00000352414,9606.ENSP00000353741,9606.ENSP00000354340,9606.ENSP00000354633,9606.ENSP00000355014,9606.ENSP00000355231,9606.ENSP00000355566,9606.ENSP00000355889,9606.ENSP00000356438,9606.ENSP00000356988,9606.ENSP00000357259,9606.ENSP00000357304,9606.ENSP00000357928,9606.ENSP00000358072,9606.ENSP00000358335,9606.ENSP00000358737,9606.ENSP00000359132,9606.ENSP00000359295,9606.ENSP00000359506,9606.ENSP00000359609,9606.ENSP00000359956,9606.ENSP00000360525,9606.ENSP00000360613,9606.ENSP00000360939,9606.ENSP00000361366,9606.ENSP00000361658,9606.ENSP00000361918,9606.ENSP00000361927,9606.ENSP00000362299,9606.ENSP00000362387,9606.ENSP00000363019,9606.ENSP00000365312,9606.ENSP00000365950,9606.ENSP00000367203,9606.ENSP00000367440,9606.ENSP00000367623,9606.ENSP00000367697,9606.ENSP00000368190,9606.ENSP00000368356,9606.ENSP00000368884,9606.ENSP00000369375,9606.ENSP00000369391,9606.ENSP00000370376,9606.ENSP00000371000,9606.ENSP00000374354,9606.ENSP00000375942,9606.ENSP00000376611,9606.ENSP00000377867,9606.ENSP00000378323,9606.ENSP00000378332,9606.ENSP00000378405,9606.ENSP00000378725,9606.ENSP00000379042,9606.ENSP00000379372,9606.ENSP00000380378,9606.ENSP00000380793,9606.ENSP00000381340,9606.ENSP00000381717,9606.ENSP00000382805,9606.ENSP00000384004,9606.ENSP00000384109,9606.ENSP00000385610,9606.ENSP00000385751,9606.ENSP00000386134,9606.ENSP00000386660,9606.ENSP00000387050,9606.ENSP00000387362,9606.ENSP00000387699,9606.ENSP00000388325,9606.ENSP00000392028,9606.ENSP00000392270,9606.ENSP00000400591,9606.ENSP00000403397,9606.ENSP00000404381,9606.ENSP00000406598,9606.ENSP00000408002,9606.ENSP00000408411,9606.ENSP00000409131,9606.ENSP00000410758,9606.ENSP00000411099,9606.ENSP00000415151,9606.ENSP00000416534,9606.ENSP00000417185,9606.ENSP00000417686,9606.ENSP00000418008,9606.ENSP00000418563,9606.ENSP00000418910,9606.ENSP00000419045,9606.ENSP00000420037,9606.ENSP00000420195,9606.ENSP00000422392,9606.ENSP00000428085,9606.ENSP00000428209,9606.ENSP00000428223,9606.ENSP00000430338,9606.ENSP00000436047,9606.ENSP00000438788,9606.ENSP00000444029,9606.ENSP00000451000,9606.ENSP00000452697,9606.ENSP00000461749,9606.ENSP00000462963,9606.ENSP00000463058,9606.ENSP00000463650,9606.ENSP00000465759,9606.ENSP00000470555,9606.ENSP00000472998,9606.ENSP00000478298,9606.ENSP00000478310,9606.ENSP00000479953,9606.ENSP00000480186,9606.ENSP00000480476,9606.ENSP00000482504
## preferredNames
## 36 FAP,PLOD1,ITGB4,CETP,PSMD5,FKBP3,PIGH,PSMA3,EIF5,PNN,PYGB,PSMD10,PPP2CB,EPHX3,PLOD3,UTP18,CPD,APOC3,SNX3,MSH6,RNF103,PANK3,ALG5,CAT,RNF11,SNRNP27,PTPN12,LSM8,PLVAP,EPO,TRPM4,MRPL4,SNRPA1,RPA1,KRAS,CCDC59,MPHOSPH6,REV1,DDX56,MARCH7,RNF38,RSL24D1,CCBL2,TOPBP1,MAN2A1,RNF138,BTBD1,SMAD2,GINS1,SPTLC1,ILVBL,COQ10B,LCAT,MCM6,CPOX,COPS4,GALNT7,COPS3,PCTP,NPC1,ERBB2,PSMA5,PRUNE,ACP1,RASA1,NIPBL,GTF2E1,COX6A2,PEX10,ABHD3,ARAF,THOC7,SNRK,UCN,APEH,HMGB2,ICE1,IL3,NFIL3,AMN,SNRPD1,ATP5L,MVD,AXL,PELP1,EVPL,LSM3,CCL11,PPID,ARF4,DESI2,MRPL13,FEM1B,MARCH3,ISCU,PDE7B,KRT2,CASP3,CSTF3,HTR1A,YME1L1,SUMO4,TENC1,ME2,ISG20L2,MAT2B,MED16,SRRM1,FOXL1,TRAK2,HGS,MORF4L1,AZIN1,SNCA,CDK10,NELFB,ACVR2B,RNF13,PPP1CC,DYRK2,UBQLN2,MGAT3,ZC3H7B,DUSP9,CRKL,IGF2R,PEX2,RAD23B,REV3L,PELI1,NAE1,FGF17,ETF1,UBA3,TAF11,PJA1,BECN1,TOMM20,RAB4A,IARS2,PTGS2,PMF1-BGLAP,KIAA0907,CDC40,ATG5,MAP3K7,CYB5R4,ATP5F1,EXTL2,DR1,FMR1,LMBRD1,ELOVL5,MAGOH,UBE2A,CMPK1,SFTPD,NUP188,SET,PPIE,HNRNPH2,ENG,TSPAN15,UBE2D1,ABI1,RBM3,KDM6A,TDP2,CA9,HSPA14,ATP6AP2,NPHS1,PRKD3,RPS6KA3,TEK,RPP40,ALOX15B,DUT,RNF6,SOD3,SACM1L,EXOSC8,TBP,INPP1,TDG,MST4,PPP3CA,TGFB1I1,BCKDK,KTN1,ERO1L,GTF2A2,PAFAH1B1,ALG3,GGT5,UBE2D2,MYO5A,BACH1,POU6F2,CUL4B,MEX3C,MARK2,NGDN,KDM3A,PLD3,UBE4A,CREB1,LAMB2,ACAD10,CHD7,STRAP,SNRPE,ZDHHC17,DNAJB14,C4orf27,VRK2,LAMP2,IMPA1,CYP21A2,WSB2,LSM5,GBE1,TLK1,CBFB,DDX46,PLTP,VWA1,SLBP,MRPS22,U2SURP,SELT,GCH1,PIGP,SRSF10,LSM6,RPL30,UBE2V2,RPL26L1,INTS8,ST3GAL4,MDH1,ACADVL,CUL7,NUP153,ATP8B1,CYP4F12,ZBTB1,SEC11A,CTDNEP1,TEFM,RBM8A,RNF115,POLRMT,SNRNP70,SPCS1,LRRC8E,POLD2,OPLAH,NR2E3
## 37 FAP,PLOD1,PSMD5,FKBP3,PIGH,PSMA3,EIF5,PNN,PYGB,PSMD10,PPP2CB,PLOD3,UTP18,CPD,APOC3,SNX3,MSH6,RNF103,ALG5,CAT,RNF11,SNRNP27,PTPN12,LSM8,PLVAP,EPO,TRPM4,MRPL4,SNRPA1,RPA1,KRAS,CCDC59,MPHOSPH6,REV1,DDX56,MARCH7,RNF38,RSL24D1,TOPBP1,MAN2A1,RNF138,BTBD1,SMAD2,RHBDF1,GINS1,LCAT,MCM6,COPS4,GALNT7,COPS3,NPC1,ERBB2,PSMA5,ACP1,RASA1,NIPBL,GTF2E1,PEX10,ARAF,THOC7,SNRK,APEH,HMGB2,ICE1,IL3,NFIL3,SNRPD1,MVD,AXL,PELP1,EVPL,LSM3,CCL11,PPID,ARF4,DESI2,MRPL13,FEM1B,MARCH3,KRT2,CASP3,CD46,CSTF3,YME1L1,SUMO4,TENC1,ISG20L2,MED16,SRRM1,FOXL1,TRAK2,HGS,MORF4L1,SNCA,CDK10,NELFB,ACVR2B,RNF13,PPP1CC,DYRK2,UBQLN2,MGAT3,ZC3H7B,DUSP9,CRKL,IGF2R,PEX2,RAD23B,REV3L,PELI1,NAE1,FGF17,ETF1,UBA3,TAF11,PJA1,BECN1,TOMM20,IARS2,PTGS2,PMF1-BGLAP,KIAA0907,CDC40,ATG5,MAP3K7,EXTL2,DR1,FMR1,MAGOH,UBE2A,SFTPD,NUP188,SET,PPIE,HNRNPH2,ENG,TSPAN15,UBE2D1,ABI1,RBM3,KDM6A,TDP2,HSPA14,ATP6AP2,NPHS1,PRKD3,RPS6KA3,TEK,RPP40,DUT,RNF6,EXOSC8,TBP,TDG,MST4,PPP3CA,TGFB1I1,BCKDK,NXF3,KTN1,ERO1L,GTF2A2,ALG3,GGT5,UBE2D2,BACH1,POU6F2,CUL4B,MEX3C,MARK2,NGDN,KDM3A,PLD3,UBE4A,CREB1,LAMB2,CHD7,STRAP,SNRPE,ZDHHC17,DNAJB14,C4orf27,VRK2,LAMP2,WSB2,LSM5,GBE1,TLK1,CBFB,DDX46,VWA1,SLBP,MRPS22,U2SURP,SELT,PIGP,SRSF10,LSM6,RPL30,UBE2V2,RPL26L1,INTS8,ST3GAL4,CUL7,NUP153,ZBTB1,SEC11A,CTDNEP1,TEFM,RBM8A,RNF115,POLRMT,KLK13,SNRNP70,SPPL2B,SPCS1,LRRC8E,POLD2,NR2E3,HOXA3
## 38 FAP,PLOD1,CETP,PSMD5,FKBP3,PIGH,PSMA3,EIF5,PNN,PYGB,PSMD10,PPP2CB,EPHX3,PLOD3,UTP18,CPD,APOC3,SNX3,MSH6,RNF103,PANK3,ALG5,CAT,RNF11,SNRNP27,PTPN12,LSM8,PLVAP,EPO,TRPM4,MRPL4,SNRPA1,RPA1,KRAS,CCDC59,MPHOSPH6,REV1,DDX56,MARCH7,RNF38,RSL24D1,CCBL2,TOPBP1,MAN2A1,RNF138,BTBD1,SMAD2,RHBDF1,GINS1,SPTLC1,ILVBL,COQ10B,LCAT,MCM6,CPOX,COPS4,GALNT7,COPS3,PCTP,NPC1,ERBB2,PSMA5,PRUNE,ACP1,RASA1,NIPBL,GTF2E1,PEX10,ABHD3,ARAF,THOC7,SNRK,APEH,HMGB2,ICE1,IL3,NFIL3,AMN,SNRPD1,ATP5L,MVD,AXL,PELP1,EVPL,LSM3,CCL11,PPID,ARF4,DESI2,MRPL13,FEM1B,MARCH3,PDE7B,KRT2,CASP3,CD46,CSTF3,HTR1A,HSD11B2,YME1L1,SUMO4,TENC1,ME2,ISG20L2,MAT2B,MED16,SRRM1,FOXL1,TRAK2,HGS,MORF4L1,AZIN1,SNCA,CDK10,NELFB,ACVR2B,RNF13,PPP1CC,DYRK2,UBQLN2,MGAT3,ZC3H7B,DUSP9,CRKL,IGF2R,PEX2,RAD23B,REV3L,PELI1,NAE1,FGF17,ETF1,UBA3,SREBF2,TAF11,PJA1,BECN1,TOMM20,RAB4A,IARS2,PTGS2,PMF1-BGLAP,KIAA0907,CDC40,ATG5,MAP3K7,ATP5F1,EXTL2,DR1,FMR1,LMBRD1,ELOVL5,MAGOH,UBE2A,CMPK1,SFTPD,NUP188,SET,PPIE,HNRNPH2,ENG,TSPAN15,UBE2D1,ABI1,RBM3,KDM6A,TDP2,HSPA14,ATP6AP2,NPHS1,PRKD3,RPS6KA3,TEK,RPP40,ALOX15B,DUT,RNF6,SACM1L,EXOSC8,TBP,INPP1,TDG,MST4,PPP3CA,TGFB1I1,BCKDK,NXF3,KTN1,ERO1L,GTF2A2,PAFAH1B1,ALG3,GGT5,UBE2D2,MYO5A,BACH1,POU6F2,CUL4B,MEX3C,MARK2,NGDN,KDM3A,PLD3,UBE4A,CREB1,LAMB2,ACAD10,CHD7,STRAP,SNRPE,ZDHHC17,DNAJB14,C4orf27,VRK2,LAMP2,IMPA1,CYP21A2,WSB2,LSM5,GBE1,TLK1,CBFB,DDX46,PLTP,VWA1,SLBP,MRPS22,U2SURP,SELT,GCH1,PIGP,SRSF10,LSM6,RPL30,UBE2V2,RPL26L1,INTS8,ST3GAL4,MDH1,ACADVL,CUL7,NUP153,ATP8B1,CYP4F12,ZBTB1,SEC11A,CTDNEP1,TEFM,RBM8A,RNF115,POLRMT,KLK13,SNRNP70,SPPL2B,SPCS1,LRRC8E,POLD2,OPLAH,NR2E3,HOXA3
## 39 FAP,PLOD1,ITGB4,CETP,PSMD5,FKBP3,PIGH,PSMA3,DHRS7,EIF5,PNN,PYGB,PSMD10,PPP2CB,EPHX3,PLOD3,UTP18,CPD,APOC3,SNX3,MSH6,RNF103,PANK3,ALG5,CAT,RNF11,SNRNP27,PTPN12,LSM8,PLVAP,EPO,TRPM4,MRPL4,SNRPA1,RPA1,KRAS,CCDC59,MPHOSPH6,REV1,DDX56,MARCH7,RNF38,RSL24D1,CCBL2,TOPBP1,MAN2A1,RNF138,BTBD1,SMAD2,RHBDF1,GINS1,SPTLC1,ILVBL,COQ10B,LCAT,MCM6,CPOX,COPS4,GALNT7,COPS3,PCTP,NPC1,ERBB2,PSMA5,PRUNE,ACP1,ATP6V1A,RASA1,NIPBL,GTF2E1,COX6A2,PEX10,ABHD3,ARAF,THOC7,SNRK,UCN,APEH,HMGB2,ICE1,IL3,NFIL3,AMN,SNRPD1,ATP5L,MVD,AXL,PELP1,EVPL,LSM3,CCL11,PPID,ARF4,DESI2,MRPL13,FEM1B,MARCH3,ISCU,PDE7B,KRT2,CASP3,CD46,CSTF3,HTR1A,HSD11B2,YME1L1,SUMO4,TENC1,ME2,ISG20L2,MAT2B,MED16,SRRM1,FOXL1,TRAK2,HGS,MORF4L1,AZIN1,SNCA,CDK10,NELFB,ACVR2B,RNF13,PPP1CC,DYRK2,UBQLN2,MGAT3,ZC3H7B,DUSP9,CRKL,IGF2R,PEX2,RAD23B,REV3L,PELI1,NAE1,FGF17,ETF1,UBA3,SREBF2,TAF11,PJA1,BECN1,TOMM20,RAB4A,IARS2,PTGS2,NIT1,PMF1-BGLAP,KIAA0907,CDC40,ATG5,MAP3K7,CYB5R4,ATP5F1,EXTL2,DR1,FMR1,LMBRD1,ELOVL5,MAGOH,UBE2A,CMPK1,SFTPD,NUP188,SET,PPIE,HNRNPH2,ENG,TSPAN15,UBE2D1,ABI1,RBM3,KDM6A,TDP2,CA9,HSPA14,ATP6AP2,NPHS1,PRKD3,RPS6KA3,TEK,RPP40,ALOX15B,DUT,RNF6,SOD3,SACM1L,EXOSC8,TBP,INPP1,TDG,MST4,PPP3CA,TGFB1I1,BCKDK,NXF3,KTN1,ERO1L,GTF2A2,PAFAH1B1,ALG3,GGT5,UBE2D2,MYO5A,BACH1,TXNRD2,POU6F2,CUL4B,MEX3C,MARK2,NGDN,KDM3A,PLD3,UBE4A,CREB1,LAMB2,ACAD10,CHD7,STRAP,TMX1,SNRPE,ZDHHC17,DNAJB14,C4orf27,VRK2,LAMP2,IMPA1,CYP21A2,WSB2,LSM5,GBE1,TLK1,CBFB,DDX46,PLTP,VWA1,SLBP,MRPS22,U2SURP,SELT,GCH1,PIGP,SRSF10,LSM6,RPL30,UBE2V2,RPL26L1,INTS8,ST3GAL4,MDH1,ACADVL,CUL7,NUP153,ATP8B1,CYP4F12,ZBTB1,SEC11A,CTDNEP1,TEFM,RBM8A,RNF115,POLRMT,KLK13,SNRNP70,SPPL2B,SPCS1,LRRC8E,POLD2,OPLAH,NR2E3,HOXA3
## 40 FAP,PLOD1,CETP,PSMD5,FKBP3,PIGH,PSMA3,EIF5,PNN,PYGB,PSMD10,PPP2CB,EPHX3,PLOD3,UTP18,CPD,APOC3,SNX3,MSH6,RNF103,PANK3,ALG5,CAT,RNF11,SNRNP27,PTPN12,LSM8,PLVAP,EPO,TRPM4,MRPL4,SNRPA1,RPA1,KRAS,CCDC59,MPHOSPH6,REV1,DDX56,MARCH7,RNF38,RSL24D1,CCBL2,TOPBP1,MAN2A1,RNF138,BTBD1,SMAD2,RHBDF1,GINS1,SPTLC1,ILVBL,LCAT,MCM6,COPS4,GALNT7,COPS3,PCTP,NPC1,ERBB2,PSMA5,ACP1,RASA1,NIPBL,GTF2E1,PEX10,ABHD3,ARAF,THOC7,SNRK,APEH,HMGB2,ICE1,IL3,NFIL3,SNRPD1,ATP5L,MVD,AXL,PELP1,EVPL,LSM3,CCL11,PPID,ARF4,DESI2,MRPL13,FEM1B,MARCH3,PDE7B,KRT2,CASP3,CSTF3,HSD11B2,YME1L1,SUMO4,TENC1,ME2,ISG20L2,MED16,SRRM1,FOXL1,TRAK2,HGS,MORF4L1,AZIN1,SNCA,CDK10,NELFB,ACVR2B,RNF13,PPP1CC,DYRK2,UBQLN2,MGAT3,ZC3H7B,DUSP9,CRKL,IGF2R,PEX2,RAD23B,REV3L,PELI1,NAE1,FGF17,ETF1,UBA3,SREBF2,TAF11,PJA1,BECN1,TOMM20,RAB4A,IARS2,PTGS2,PMF1-BGLAP,KIAA0907,CDC40,ATG5,MAP3K7,ATP5F1,EXTL2,DR1,FMR1,ELOVL5,MAGOH,UBE2A,CMPK1,SFTPD,NUP188,PPIE,HNRNPH2,ENG,TSPAN15,UBE2D1,ABI1,RBM3,KDM6A,TDP2,HSPA14,ATP6AP2,NPHS1,PRKD3,RPS6KA3,TEK,RPP40,ALOX15B,DUT,RNF6,SACM1L,EXOSC8,TBP,INPP1,TDG,MST4,PPP3CA,TGFB1I1,BCKDK,KTN1,ERO1L,GTF2A2,PAFAH1B1,ALG3,GGT5,UBE2D2,MYO5A,BACH1,POU6F2,CUL4B,MEX3C,MARK2,NGDN,KDM3A,PLD3,UBE4A,CREB1,LAMB2,ACAD10,CHD7,STRAP,SNRPE,ZDHHC17,DNAJB14,C4orf27,VRK2,LAMP2,IMPA1,CYP21A2,WSB2,LSM5,GBE1,TLK1,CBFB,DDX46,PLTP,VWA1,SLBP,MRPS22,U2SURP,SELT,PIGP,SRSF10,LSM6,RPL30,UBE2V2,RPL26L1,INTS8,ST3GAL4,MDH1,ACADVL,CUL7,NUP153,ATP8B1,CYP4F12,ZBTB1,SEC11A,CTDNEP1,TEFM,RBM8A,RNF115,POLRMT,KLK13,SNRNP70,SPPL2B,SPCS1,LRRC8E,POLD2,NR2E3
## 41 FAP,PLOD1,CETP,PSMD5,FKBP3,PIGH,PSMA3,EIF5,PNN,PSMD10,PPP2CB,PLOD3,UTP18,CPD,APOC3,SNX3,MSH6,RNF103,PANK3,ALG5,CAT,RNF11,SNRNP27,PTPN12,LSM8,PLVAP,EPO,TRPM4,MRPL4,SNRPA1,RPA1,KRAS,CCDC59,MPHOSPH6,REV1,DDX56,MARCH7,RNF38,RSL24D1,CCBL2,TOPBP1,MAN2A1,RNF138,BTBD1,SMAD2,RHBDF1,GINS1,SPTLC1,LCAT,MCM6,CPOX,COPS4,GALNT7,COPS3,PCTP,NPC1,ERBB2,PSMA5,ACP1,RASA1,NIPBL,GTF2E1,PEX10,ABHD3,ARAF,THOC7,SNRK,APEH,HMGB2,ICE1,IL3,NFIL3,AMN,SNRPD1,ATP5L,MVD,AXL,PELP1,EVPL,LSM3,CCL11,PPID,ARF4,DESI2,MRPL13,FEM1B,MARCH3,PDE7B,KRT2,CASP3,CSTF3,HTR1A,YME1L1,SUMO4,TENC1,ISG20L2,MED16,SRRM1,FOXL1,TRAK2,HGS,MORF4L1,AZIN1,SNCA,CDK10,NELFB,ACVR2B,RNF13,PPP1CC,DYRK2,UBQLN2,MGAT3,ZC3H7B,DUSP9,CRKL,IGF2R,PEX2,RAD23B,REV3L,PELI1,NAE1,FGF17,ETF1,UBA3,TAF11,PJA1,BECN1,TOMM20,IARS2,PTGS2,NIT1,PMF1-BGLAP,KIAA0907,CDC40,ATG5,MAP3K7,ATP5F1,EXTL2,DR1,FMR1,LMBRD1,ELOVL5,MAGOH,UBE2A,CMPK1,SFTPD,NUP188,PPIE,HNRNPH2,ENG,TSPAN15,UBE2D1,ABI1,RBM3,KDM6A,TDP2,HSPA14,ATP6AP2,NPHS1,PRKD3,RPS6KA3,TEK,RPP40,DUT,RNF6,EXOSC8,TBP,TDG,MST4,PPP3CA,TGFB1I1,BCKDK,KTN1,ERO1L,GTF2A2,PAFAH1B1,ALG3,GGT5,UBE2D2,BACH1,POU6F2,CUL4B,MEX3C,MARK2,NGDN,KDM3A,PLD3,UBE4A,CREB1,LAMB2,CHD7,STRAP,SNRPE,ZDHHC17,DNAJB14,C4orf27,VRK2,LAMP2,WSB2,LSM5,TLK1,CBFB,DDX46,VWA1,SLBP,MRPS22,U2SURP,SELT,GCH1,PIGP,SRSF10,LSM6,RPL30,UBE2V2,RPL26L1,INTS8,ST3GAL4,CUL7,NUP153,ZBTB1,SEC11A,CTDNEP1,TEFM,RBM8A,RNF115,POLRMT,KLK13,SNRNP70,SPPL2B,SPCS1,LRRC8E,POLD2,OPLAH,NR2E3
## p_value fdr description
## 36 1.53e-12 1.96e-08 Cellular metabolic process
## 37 1.29e-11 8.32e-08 Macromolecule metabolic process
## 38 3.70e-11 1.59e-07 Organic substance metabolic process
## 39 9.14e-11 2.93e-07 Metabolic process
## 40 1.47e-10 3.79e-07 Primary metabolic process
## 41 2.23e-10 4.77e-07 Nitrogen compound metabolic process