Co-expression network analysis of Hypertension
Loranda_Calderon
2024-10-11
library(tidyverse)## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
## ✔ dplyr 1.1.4 ✔ readr 2.1.5
## ✔ forcats 1.0.0 ✔ stringr 1.5.1
## ✔ ggplot2 3.5.2 ✔ tibble 3.3.0
## ✔ lubridate 1.9.4 ✔ tidyr 1.3.1
## ✔ purrr 1.0.4
## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
## ✖ dplyr::filter() masks stats::filter()
## ✖ dplyr::lag() masks stats::lag()
## ℹ Use the conflicted package (<http://conflicted.r-lib.org/>) to force all conflicts to become errorslibrary(WGCNA)## Loading required package: dynamicTreeCut
## Loading required package: fastcluster
##
## Attaching package: 'fastcluster'
##
## The following object is masked from 'package:stats':
##
## hclust
##
##
##
## Attaching package: 'WGCNA'
##
## The following object is masked from 'package:stats':
##
## corlibrary(conflicted)
options(stringsAsFactors = FALSE)# Load the gene expression dataset for HTN
HTNdata <- read.csv("/Users/lorandacalderonzamora/Downloads/datExpr_integrative_HTN.csv", row.names = NULL)
dim(HTNdata)## [1] 18006 26names(HTNdata)## [1] "X" "GSM700797" "GSM700798" "GSM700799" "GSM700800" "GSM700801"
## [7] "GSM700802" "GSM700803" "GSM701161" "GSM701162" "GSM701163" "GSM701164"
## [13] "GSM701165" "GSM701166" "GSM701167" "GSM701168" "GSM701169" "GSM701170"
## [19] "GSM701171" "GSM701173" "GSM701174" "GSM609526" "GSM609527" "GSM609528"
## [25] "GSM609529" "GSM609530"# Set row names and transposing the Expression matrix
rownames(HTNdata) <- HTNdata$X
HTNdata <- HTNdata[, -1]
datExpr <- as.data.frame(t(HTNdata))dim(datExpr)## [1] 25 18006gsg = goodSamplesGenes(datExpr, verbose = 3);## Flagging genes and samples with too many missing values...
## ..step 1gsg$allOK## [1] TRUEsampleTree = hclust(dist(datExpr), method = "average");
sizeGrWindow(12,9)
par(cex = 0.6);
par(mar = c(0,4,2,0))
plot(sampleTree, main = "Sample clustering to detect outliers", sub="", xlab="", cex.lab = 1.5,
cex.axis = 1.5, cex.main = 2)# Load the trait metadata associated with the HTN samples
traitData <- read.csv("/Users/lorandacalderonzamora/Downloads/datMeta_HTN.csv")
dim(traitData)## [1] 26 3names(traitData)## [1] "geo_accession" "Disease" "Gender"# Match Expression data with trait metadata
sampleNames <- rownames(datExpr)
head(traitData$geo_accession)## [1] "GSM700797" "GSM700798" "GSM700799" "GSM700800" "GSM700801" "GSM700802"all(sampleNames %in% traitData$geo_accession)## [1] TRUE# Align trait data to match Expression samples
traitRows <- match(sampleNames, traitData$geo_accession)
datTraits <- traitData[traitRows, ]
rownames(datTraits) <- datTraits$geo_accession# Converte trait variables to numeric format
datTraits[] <- lapply(datTraits, function(x) {
if (is.character(x) || is.factor(x)) {
as.numeric(as.factor(x))
} else {
x
}
})
datTraits_clean <- datTraits[, sapply(datTraits, is.numeric)]
str(datTraits_clean)## 'data.frame': 25 obs. of 3 variables:
## $ geo_accession: num 6 7 8 9 10 11 12 13 14 15 ...
## $ Disease : num 1 1 2 2 2 2 2 1 1 1 ...
## $ Gender : num 2 2 2 2 2 2 2 2 2 2 ...# Sample clustering and visualization of traits as heatmap
sampleTree2 <- hclust(dist(datExpr), method = "average")
traitColors <- numbers2colors(datTraits_clean, signed = FALSE)
plotDendroAndColors(sampleTree2, traitColors,
groupLabels = names(datTraits_clean),
main = "Sample dendrogram and trait heatmap")
save(datExpr, datTraits_clean, file = "HTNdataInput.RData")lnames = load(file = "HTNdataInput.RData");
#The variable lnames contains the names of loaded variables.
lnames## [1] "datExpr" "datTraits_clean"# Filter the least variable genes (optional)
variance_genes <- apply(datExpr, 2, var)
datExpr_filtered <- datExpr[, variance_genes > quantile(variance_genes, 0.70)]# Select a narrower range of powers due to few samples
powers = c(1:6)
sft = pickSoftThreshold(datExpr_filtered, powerVector = powers, verbose = 5)## pickSoftThreshold: will use block size 5402.
## pickSoftThreshold: calculating connectivity for given powers...
## ..working on genes 1 through 5402 of 5402## Warning: executing %dopar% sequentially: no parallel backend registered## Power SFT.R.sq slope truncated.R.sq mean.k. median.k. max.k.
## 1 1 0.93800 2.8000 0.958 3640 3840 4380
## 2 2 0.91600 1.4000 0.928 2700 2890 3720
## 3 3 0.81400 0.8200 0.779 2100 2250 3230
## 4 4 0.55900 0.4740 0.445 1670 1780 2840
## 5 5 0.17400 0.2220 0.130 1360 1430 2520
## 6 6 0.00143 0.0206 0.129 1130 1170 2260sizeGrWindow(9, 5)
par(mfrow = c(1, 2))
cex1 = 0.9
plot(sft$fitIndices[,1], -sign(sft$fitIndices[,3]) * sft$fitIndices[,2],
xlab = "Soft Threshold (power)",
ylab = "Scale Free Topology Model Fit, signed R^2", type = "n",
main = "Scale independence")
text(sft$fitIndices[,1], -sign(sft$fitIndices[,3]) * sft$fitIndices[,2],
labels = powers, cex = cex1, col = "red")
abline(h = 0.80, col = "red") # Ajuste del umbral a 0.80
plot(sft$fitIndices[,1], sft$fitIndices[,5],
xlab = "Soft Threshold (power)",
ylab = "Mean Connectivity", type = "n",
main = "Mean connectivity")
text(sft$fitIndices[,1], sft$fitIndices[,5], labels = powers, cex = cex1, col = "red")# Construction of Co-expression network and module detection
net = blockwiseModules(
datExpr,
power = 3,
TOMType = "unsigned",
minModuleSize = 200,
reassignThreshold = 0,
mergeCutHeight = 0.20,
numericLabels = TRUE,
pamRespectsDendro = FALSE,
saveTOMs = TRUE,
saveTOMFileBase = "TOM_HTN",
verbose = 3
)## Calculating module eigengenes block-wise from all genes
## Flagging genes and samples with too many missing values...
## ..step 1
## ....pre-clustering genes to determine blocks..
## Projective K-means:
## ..k-means clustering..
## ..merging smaller clusters...
## Block sizes:
## gBlocks
## 1 2 3 4
## 5000 4994 4953 3059
## ..Working on block 1 .
## TOM calculation: adjacency..
## ..will not use multithreading.
## Fraction of slow calculations: 0.000000
## ..connectivity..
## ..matrix multiplication (system BLAS)..
## ..normalization..
## ..done.
## ..saving TOM for block 1 into file TOM_HTN-block.1.RData
## ....clustering..
## ....detecting modules..
## ....calculating module eigengenes..
## ....checking kME in modules..
## ..removing 17 genes from module 1 because their KME is too low.
## ..removing 10 genes from module 2 because their KME is too low.
## ..Working on block 2 .
## TOM calculation: adjacency..
## ..will not use multithreading.
## Fraction of slow calculations: 0.000000
## ..connectivity..
## ..matrix multiplication (system BLAS)..
## ..normalization..
## ..done.
## ..saving TOM for block 2 into file TOM_HTN-block.2.RData
## ....clustering..
## ....detecting modules..
## ....calculating module eigengenes..
## ....checking kME in modules..
## ..removing 1 genes from module 1 because their KME is too low.
## ..Working on block 3 .
## TOM calculation: adjacency..
## ..will not use multithreading.
## Fraction of slow calculations: 0.000000
## ..connectivity..
## ..matrix multiplication (system BLAS)..
## ..normalization..
## ..done.
## ..saving TOM for block 3 into file TOM_HTN-block.3.RData
## ....clustering..
## ....detecting modules..
## ....calculating module eigengenes..
## ....checking kME in modules..
## ..removing 289 genes from module 1 because their KME is too low.
## ..removing 23 genes from module 2 because their KME is too low.
## ..Working on block 4 .
## TOM calculation: adjacency..
## ..will not use multithreading.
## Fraction of slow calculations: 0.000000
## ..connectivity..
## ..matrix multiplication (system BLAS)..
## ..normalization..
## ..done.
## ..saving TOM for block 4 into file TOM_HTN-block.4.RData
## ....clustering..
## ....detecting modules..
## ....calculating module eigengenes..
## ....checking kME in modules..
## ..removing 61 genes from module 1 because their KME is too low.
## ..removing 20 genes from module 2 because their KME is too low.
## ..removing 22 genes from module 3 because their KME is too low.
## ..removing 9 genes from module 4 because their KME is too low.
## ..removing 2 genes from module 5 because their KME is too low.
## ..merging modules that are too close..
## mergeCloseModules: Merging modules whose distance is less than 0.2
## Calculating new MEs...# Visualizing Gene dendrograms with module colors
sizeGrWindow(12, 9)
mergedColors = labels2colors(net$colors)
for (i in 1:length(net$dendrograms)) {
plotDendroAndColors(
net$dendrograms[[i]],
mergedColors[net$blockGenes[[i]]],
"Module colors",
dendroLabels = FALSE,
hang = 0.03,
addGuide = TRUE, guideHang = 0.05
)
}table(net$colors) # Gene counts per module##
## 0 1 2 3 4 5 6 7 8
## 454 7604 3954 3213 749 687 553 417 375# Module Eigengene
MEs = net$MEs
moduleTraitCor = cor(MEs, datTraits_clean, use = "pairwise.complete.obs")
moduleTraitPvalue = corPvalueStudent(moduleTraitCor, nrow(datExpr))
print(moduleTraitCor) ## geo_accession Disease Gender
## ME4 -0.6483474 -0.07845911 -0.44483271
## ME1 -0.8655749 -0.33333252 -0.54553320
## ME5 -0.6324408 -0.10503421 -0.36858985
## ME3 0.6304021 0.46728838 0.45731648
## ME7 0.4917708 0.52045864 0.32596445
## ME2 0.7781292 0.07073497 0.43081884
## ME6 -0.1102821 -0.43033079 -0.16376015
## ME8 0.2939836 -0.11332249 0.14371668
## ME0 0.1270492 -0.39573098 -0.02598149print(moduleTraitPvalue) ## geo_accession Disease Gender
## ME4 4.564978e-04 0.709306999 0.025875470
## ME1 2.318872e-08 0.103462942 0.004794071
## ME5 6.935196e-04 0.617307386 0.069825454
## ME3 7.304997e-04 0.018512725 0.021536876
## ME7 1.253170e-02 0.007648656 0.111797515
## ME2 4.670078e-06 0.736878980 0.031557810
## ME6 5.997322e-01 0.031772341 0.434106699
## ME8 1.537500e-01 0.589647749 0.493113100
## ME0 5.450564e-01 0.050214081 0.901887678# Extract the correlations and p-values for the trait "Disease"
cor_Disease = moduleTraitCor[, "Disease"]
pval_Disease = moduleTraitPvalue[, "Disease"]
best_module = which.max(abs(cor_Disease))
print(paste("Most significant module:", names(cor_Disease)[best_module]))## [1] "Most significant module: ME7"print(paste("Correlation:", cor_Disease[best_module]))## [1] "Correlation: 0.520458641384091"print(paste("P-value:", pval_Disease[best_module]))## [1] "P-value: 0.00764865587431864"# Extract most significant module
module7_genes = names(datExpr)[net$colors == 7]
module3_genes = names(datExpr)[net$colors == 3]# PPI network analysis
library(STRINGdb)
string_db <- STRINGdb$new(version = "11.5", species = 9606,
score_threshold = 400, input_directory = "")# Mapping Module 0 genes and visualizing Protein-Protein Interaction Network
module7_genes <- gsub("\\..*", "", module7_genes)
module3_genes <- gsub("\\..*", "", module3_genes)
df_genes <- c(module7_genes, module3_genes)
df_genes <- data.frame(ENSEMBL = df_genes)
mapped_genes <- string_db$map(df_genes, "ENSEMBL", removeUnmappedRows = TRUE)## Warning: we couldn't map to STRING 10% of your identifiersprint(head(mapped_genes))## ENSEMBL STRING_id
## 1 ENSG00000001167 9606.ENSP00000345702
## 2 ENSG00000002822 9606.ENSP00000385334
## 3 ENSG00000004478 9606.ENSP00000001008
## 4 ENSG00000006712 9606.ENSP00000221265
## 5 ENSG00000007080 9606.ENSP00000471455
## 6 ENSG00000007908 9606.ENSP00000331736unmapped_genes <- setdiff(df_genes$ENSEMBL, mapped_genes$ENSEMBL)
print(unmapped_genes)## [1] "ENSG00000121388" "ENSG00000141979" "ENSG00000175772" "ENSG00000177822"
## [5] "ENSG00000178457" "ENSG00000185834" "ENSG00000201700" "ENSG00000206914"
## [9] "ENSG00000214297" "ENSG00000221930" "ENSG00000224897" "ENSG00000228095"
## [13] "ENSG00000228881" "ENSG00000229802" "ENSG00000232289" "ENSG00000232560"
## [17] "ENSG00000232804" "ENSG00000234857" "ENSG00000236565" "ENSG00000251992"
## [21] "ENSG00000254995" "ENSG00000257987" "ENSG00000260372" "ENSG00000261069"
## [25] "ENSG00000261303" "ENSG00000261992" "ENSG00000262587" "ENSG00000263798"
## [29] "ENSG00000266302" "ENSG00000268635" "ENSG00000274780" "ENSG00000274962"
## [33] "ENSG00000275117" "ENSG00000275125" "ENSG00000276480" "ENSG00000276833"
## [37] "ENSG00000277018" "ENSG00000279863" "ENSG00000280689" "ENSG00000281166"
## [41] "ENSG00000281309" "ENSG00000282438" "ENSG00000282844" "ENSG00000284936"
## [45] "ENSG00000284979" "ENSG00000285222" "ENSG00000285238" "ENSG00000285314"
## [49] "ENSG00000285502" "ENSG00000285708" "ENSG00000285959" "ENSG00000286001"
## [53] "ENSG00000288000" "ENSG00000288293" "ENSG00000288318" "ENSG00000288401"
## [57] "ENSG00000290767" "ENSG00000291827" "ENSG00000292366" "ENSG00000099869"
## [61] "ENSG00000108958" "ENSG00000125997" "ENSG00000129864" "ENSG00000131797"
## [65] "ENSG00000142163" "ENSG00000167798" "ENSG00000168367" "ENSG00000168405"
## [69] "ENSG00000170846" "ENSG00000171570" "ENSG00000171658" "ENSG00000171889"
## [73] "ENSG00000173867" "ENSG00000174171" "ENSG00000174977" "ENSG00000175604"
## [77] "ENSG00000175967" "ENSG00000176679" "ENSG00000176728" "ENSG00000176840"
## [81] "ENSG00000176912" "ENSG00000177855" "ENSG00000178146" "ENSG00000178723"
## [85] "ENSG00000178803" "ENSG00000178947" "ENSG00000179073" "ENSG00000179141"
## [89] "ENSG00000179342" "ENSG00000179577" "ENSG00000180422" "ENSG00000180673"
## [93] "ENSG00000180769" "ENSG00000180846" "ENSG00000180869" "ENSG00000182366"
## [97] "ENSG00000183753" "ENSG00000184774" "ENSG00000185168" "ENSG00000185390"
## [101] "ENSG00000185904" "ENSG00000186076" "ENSG00000188662" "ENSG00000189223"
## [105] "ENSG00000196205" "ENSG00000196243" "ENSG00000196951" "ENSG00000197083"
## [109] "ENSG00000197503" "ENSG00000197670" "ENSG00000199133" "ENSG00000200241"
## [113] "ENSG00000201340" "ENSG00000203581" "ENSG00000203739" "ENSG00000203930"
## [117] "ENSG00000203993" "ENSG00000205236" "ENSG00000205578" "ENSG00000207165"
## [121] "ENSG00000207713" "ENSG00000212694" "ENSG00000212766" "ENSG00000213071"
## [125] "ENSG00000213373" "ENSG00000214194" "ENSG00000215068" "ENSG00000215196"
## [129] "ENSG00000216560" "ENSG00000217702" "ENSG00000222041" "ENSG00000223198"
## [133] "ENSG00000223658" "ENSG00000224861" "ENSG00000224975" "ENSG00000225077"
## [137] "ENSG00000225399" "ENSG00000225470" "ENSG00000225855" "ENSG00000225930"
## [141] "ENSG00000225938" "ENSG00000225980" "ENSG00000226122" "ENSG00000226137"
## [145] "ENSG00000226746" "ENSG00000227802" "ENSG00000227888" "ENSG00000228305"
## [149] "ENSG00000228401" "ENSG00000228502" "ENSG00000228532" "ENSG00000228691"
## [153] "ENSG00000229547" "ENSG00000229644" "ENSG00000229921" "ENSG00000229939"
## [157] "ENSG00000230043" "ENSG00000230669" "ENSG00000231608" "ENSG00000232320"
## [161] "ENSG00000232569" "ENSG00000232624" "ENSG00000232677" "ENSG00000233054"
## [165] "ENSG00000233250" "ENSG00000234390" "ENSG00000234507" "ENSG00000235436"
## [169] "ENSG00000236534" "ENSG00000236882" "ENSG00000236972" "ENSG00000237149"
## [173] "ENSG00000237154" "ENSG00000238105" "ENSG00000240233" "ENSG00000241962"
## [177] "ENSG00000242153" "ENSG00000243415" "ENSG00000243819" "ENSG00000246082"
## [181] "ENSG00000249936" "ENSG00000252128" "ENSG00000252481" "ENSG00000255267"
## [185] "ENSG00000255284" "ENSG00000255425" "ENSG00000256116" "ENSG00000257267"
## [189] "ENSG00000258573" "ENSG00000258653" "ENSG00000259781" "ENSG00000261613"
## [193] "ENSG00000261846" "ENSG00000262223" "ENSG00000262420" "ENSG00000262666"
## [197] "ENSG00000262845" "ENSG00000263057" "ENSG00000263243" "ENSG00000263296"
## [201] "ENSG00000263590" "ENSG00000265257" "ENSG00000266714" "ENSG00000267053"
## [205] "ENSG00000267426" "ENSG00000268173" "ENSG00000268864" "ENSG00000270149"
## [209] "ENSG00000270316" "ENSG00000271806" "ENSG00000271889" "ENSG00000272578"
## [213] "ENSG00000272670" "ENSG00000272741" "ENSG00000272916" "ENSG00000273294"
## [217] "ENSG00000273572" "ENSG00000273707" "ENSG00000273782" "ENSG00000274020"
## [221] "ENSG00000274473" "ENSG00000274488" "ENSG00000274638" "ENSG00000274821"
## [225] "ENSG00000275079" "ENSG00000275331" "ENSG00000275338" "ENSG00000275428"
## [229] "ENSG00000275568" "ENSG00000275719" "ENSG00000275779" "ENSG00000275798"
## [233] "ENSG00000275851" "ENSG00000275867" "ENSG00000276087" "ENSG00000276155"
## [237] "ENSG00000276371" "ENSG00000276712" "ENSG00000276996" "ENSG00000277033"
## [241] "ENSG00000277209" "ENSG00000277222" "ENSG00000277236" "ENSG00000277377"
## [245] "ENSG00000277429" "ENSG00000277656" "ENSG00000277730" "ENSG00000278006"
## [249] "ENSG00000278183" "ENSG00000278192" "ENSG00000278274" "ENSG00000278326"
## [253] "ENSG00000278563" "ENSG00000278624" "ENSG00000278812" "ENSG00000279610"
## [257] "ENSG00000279873" "ENSG00000280148" "ENSG00000280498" "ENSG00000280549"
## [261] "ENSG00000280610" "ENSG00000280661" "ENSG00000280808" "ENSG00000281089"
## [265] "ENSG00000281178" "ENSG00000281221" "ENSG00000281245" "ENSG00000281320"
## [269] "ENSG00000281500" "ENSG00000281540" "ENSG00000281614" "ENSG00000281626"
## [273] "ENSG00000281766" "ENSG00000281818" "ENSG00000281879" "ENSG00000281931"
## [277] "ENSG00000282603" "ENSG00000282739" "ENSG00000282750" "ENSG00000282891"
## [281] "ENSG00000282941" "ENSG00000283018" "ENSG00000283100" "ENSG00000283496"
## [285] "ENSG00000283580" "ENSG00000283593" "ENSG00000283859" "ENSG00000283927"
## [289] "ENSG00000284057" "ENSG00000284161" "ENSG00000284292" "ENSG00000284320"
## [293] "ENSG00000284468" "ENSG00000284512" "ENSG00000284564" "ENSG00000284697"
## [297] "ENSG00000284752" "ENSG00000284774" "ENSG00000284868" "ENSG00000284872"
## [301] "ENSG00000284915" "ENSG00000284923" "ENSG00000284925" "ENSG00000284927"
## [305] "ENSG00000284958" "ENSG00000285034" "ENSG00000285119" "ENSG00000285121"
## [309] "ENSG00000285241" "ENSG00000285243" "ENSG00000285269" "ENSG00000285281"
## [313] "ENSG00000285376" "ENSG00000285379" "ENSG00000285390" "ENSG00000285411"
## [317] "ENSG00000285434" "ENSG00000285443" "ENSG00000285485" "ENSG00000285493"
## [321] "ENSG00000285602" "ENSG00000285645" "ENSG00000286070" "ENSG00000286139"
## [325] "ENSG00000286235" "ENSG00000286905" "ENSG00000287908" "ENSG00000288185"
## [329] "ENSG00000288191" "ENSG00000288217" "ENSG00000288243" "ENSG00000288257"
## [333] "ENSG00000288369" "ENSG00000288427" "ENSG00000288499" "ENSG00000288602"
## [337] "ENSG00000288642" "ENSG00000288721" "ENSG00000288894" "ENSG00000289517"
## [341] "ENSG00000289694" "ENSG00000290230" "ENSG00000290517" "ENSG00000290523"
## [345] "ENSG00000290993" "ENSG00000291054" "ENSG00000291093" "ENSG00000291224"
## [349] "ENSG00000291375" "ENSG00000291387" "ENSG00000291426" "ENSG00000291465"
## [353] "ENSG00000291479" "ENSG00000291485" "ENSG00000291501" "ENSG00000291520"
## [357] "ENSG00000291608" "ENSG00000291669" "ENSG00000291672" "ENSG00000291692"
## [361] "ENSG00000291761" "ENSG00000291802" "ENSG00000291814" "ENSG00000291823"
## [365] "ENSG00000291927" "ENSG00000291936" "ENSG00000291941" "ENSG00000291964"
## [369] "ENSG00000291994" "ENSG00000292028" "ENSG00000292063" "ENSG00000292097"
## [373] "ENSG00000292140" "ENSG00000292155" "ENSG00000292170" "ENSG00000292177"
## [377] "ENSG00000292214" "ENSG00000292264" "ENSG00000292279" "ENSG00000292288"
## [381] "ENSG00000292301" "ENSG00000292332" "ENSG00000293442" "ENSG00000299111"
## [385] "ENSG00000306774" "ENSG00000307722" "ENSG00000309008"# Top 1000 selecction
top_genes <- mapped_genes %>%
slice(1:1000)# Plot Protein–Protein Interaction Network with STRINGdb
string_db$plot_network(top_genes$STRING_id)
interactions <- string_db$get_interactions(top_genes$STRING_id)
head(interactions)## from to combined_score
## 1 9606.ENSP00000017003 9606.ENSP00000035307 516
## 2 9606.ENSP00000017003 9606.ENSP00000035307 516
## 3 9606.ENSP00000002829 9606.ENSP00000043402 435
## 4 9606.ENSP00000002829 9606.ENSP00000043402 435
## 5 9606.ENSP00000020926 9606.ENSP00000054666 530
## 6 9606.ENSP00000020926 9606.ENSP00000054666 530# Functional enrichment analysis
enrichment_results_GO <- string_db$get_enrichment(
string_ids = mapped_genes$STRING_id,
category = "Process", # GO "Process" or "Pathway" by KEGG
methodMT = "fdr",
iea = FALSE
)## Warning in string_db$get_enrichment(string_ids = mapped_genes$STRING_id, :
## methodMT parameter is depecated. Only FDR correction is available.## Warning in string_db$get_enrichment(string_ids = mapped_genes$STRING_id, : iea
## parameter is deprecated.head(enrichment_results_GO)## category term number_of_genes number_of_genes_in_background
## 23 Process GO:0044281 490 1684
## 24 Process GO:0006082 317 964
## 25 Process GO:0043436 307 944
## 26 Process GO:0019752 284 853
## 27 Process GO:0044282 168 424
## 28 Process GO:0008152 1652 8298
## ncbiTaxonId
## 23 9606
## 24 9606
## 25 9606
## 26 9606
## 27 9606
## 28 9606
## inputGenes
## 23 9606.ENSP00000002165,9606.ENSP00000017003,9606.ENSP00000035307,9606.ENSP00000039007,9606.ENSP00000200676,9606.ENSP00000202967,9606.ENSP00000207870,9606.ENSP00000215832,9606.ENSP00000215838,9606.ENSP00000215882,9606.ENSP00000216180,9606.ENSP00000216259,9606.ENSP00000216465,9606.ENSP00000216605,9606.ENSP00000216862,9606.ENSP00000216951,9606.ENSP00000217254,9606.ENSP00000217426,9606.ENSP00000219240,9606.ENSP00000219345,9606.ENSP00000219481,9606.ENSP00000220764,9606.ENSP00000221403,9606.ENSP00000221700,9606.ENSP00000221930,9606.ENSP00000222115,9606.ENSP00000222982,9606.ENSP00000223026,9606.ENSP00000223029,9606.ENSP00000223114,9606.ENSP00000224807,9606.ENSP00000225573,9606.ENSP00000226253,9606.ENSP00000228476,9606.ENSP00000228606,9606.ENSP00000229239,9606.ENSP00000229416,9606.ENSP00000229447,9606.ENSP00000229583,9606.ENSP00000230048,9606.ENSP00000230431,9606.ENSP00000231420,9606.ENSP00000231887,9606.ENSP00000232219,9606.ENSP00000233575,9606.ENSP00000234111,9606.ENSP00000234677,9606.ENSP00000235345,9606.ENSP00000235835,9606.ENSP00000236959,9606.ENSP00000238018,9606.ENSP00000239231,9606.ENSP00000242592,9606.ENSP00000243167,9606.ENSP00000244137,9606.ENSP00000244217,9606.ENSP00000244527,9606.ENSP00000249910,9606.ENSP00000251108,9606.ENSP00000251566,9606.ENSP00000252486,9606.ENSP00000253382,9606.ENSP00000253801,9606.ENSP00000254190,9606.ENSP00000254878,9606.ENSP00000255192,9606.ENSP00000255389,9606.ENSP00000255681,9606.ENSP00000256999,9606.ENSP00000257770,9606.ENSP00000258168,9606.ENSP00000258403,9606.ENSP00000258494,9606.ENSP00000259727,9606.ENSP00000260116,9606.ENSP00000260118,9606.ENSP00000260599,9606.ENSP00000260600,9606.ENSP00000261170,9606.ENSP00000261434,9606.ENSP00000261507,9606.ENSP00000261596,9606.ENSP00000261714,9606.ENSP00000261772,9606.ENSP00000261835,9606.ENSP00000262288,9606.ENSP00000262290,9606.ENSP00000263035,9606.ENSP00000263038,9606.ENSP00000263080,9606.ENSP00000263317,9606.ENSP00000263383,9606.ENSP00000263816,9606.ENSP00000263980,9606.ENSP00000263985,9606.ENSP00000264424,9606.ENSP00000264775,9606.ENSP00000264784,9606.ENSP00000264914,9606.ENSP00000264932,9606.ENSP00000264990,9606.ENSP00000265113,9606.ENSP00000265174,9606.ENSP00000265372,9606.ENSP00000265395,9606.ENSP00000265605,9606.ENSP00000265838,9606.ENSP00000265881,9606.ENSP00000266505,9606.ENSP00000266736,9606.ENSP00000267436,9606.ENSP00000267584,9606.ENSP00000267842,9606.ENSP00000268125,9606.ENSP00000268835,9606.ENSP00000269159,9606.ENSP00000269848,9606.ENSP00000272252,9606.ENSP00000273450,9606.ENSP00000274353,9606.ENSP00000274813,9606.ENSP00000276055,9606.ENSP00000276461,9606.ENSP00000276651,9606.ENSP00000278025,9606.ENSP00000278618,9606.ENSP00000278840,9606.ENSP00000279263,9606.ENSP00000281182,9606.ENSP00000281243,9606.ENSP00000281317,9606.ENSP00000283871,9606.ENSP00000284503,9606.ENSP00000285093,9606.ENSP00000285379,9606.ENSP00000286298,9606.ENSP00000286621,9606.ENSP00000286648,9606.ENSP00000286733,9606.ENSP00000287143,9606.ENSP00000287713,9606.ENSP00000287996,9606.ENSP00000288014,9606.ENSP00000288532,9606.ENSP00000289004,9606.ENSP00000289416,9606.ENSP00000290429,9606.ENSP00000291295,9606.ENSP00000291670,9606.ENSP00000292180,9606.ENSP00000293217,9606.ENSP00000293404,9606.ENSP00000294016,9606.ENSP00000294973,9606.ENSP00000295256,9606.ENSP00000296424,9606.ENSP00000296522,9606.ENSP00000298198,9606.ENSP00000298248,9606.ENSP00000298910,9606.ENSP00000299022,9606.ENSP00000299155,9606.ENSP00000299299,9606.ENSP00000299697,9606.ENSP00000300051,9606.ENSP00000300079,9606.ENSP00000300688,9606.ENSP00000300784,9606.ENSP00000301149,9606.ENSP00000301175,9606.ENSP00000301452,9606.ENSP00000301587,9606.ENSP00000301729,9606.ENSP00000301891,9606.ENSP00000302108,9606.ENSP00000302586,9606.ENSP00000302620,9606.ENSP00000302630,9606.ENSP00000302851,9606.ENSP00000303246,9606.ENSP00000303356,9606.ENSP00000303575,9606.ENSP00000304440,9606.ENSP00000305221,9606.ENSP00000306459,9606.ENSP00000306561,9606.ENSP00000306817,9606.ENSP00000307188,9606.ENSP00000307297,9606.ENSP00000307697,9606.ENSP00000307900,9606.ENSP00000307911,9606.ENSP00000309477,9606.ENSP00000309749,9606.ENSP00000310241,9606.ENSP00000310565,9606.ENSP00000310688,9606.ENSP00000311224,9606.ENSP00000311453,9606.ENSP00000311984,9606.ENSP00000312250,9606.ENSP00000312652,9606.ENSP00000312987,9606.ENSP00000313377,9606.ENSP00000313398,9606.ENSP00000313432,9606.ENSP00000314508,9606.ENSP00000315644,9606.ENSP00000316905,9606.ENSP00000317721,9606.ENSP00000317842,9606.ENSP00000318318,9606.ENSP00000318351,9606.ENSP00000318602,9606.ENSP00000318867,9606.ENSP00000319501,9606.ENSP00000319622,9606.ENSP00000319814,9606.ENSP00000320309,9606.ENSP00000320337,9606.ENSP00000320401,9606.ENSP00000321424,9606.ENSP00000321874,9606.ENSP00000322181,9606.ENSP00000323071,9606.ENSP00000323811,9606.ENSP00000324105,9606.ENSP00000324343,9606.ENSP00000324648,9606.ENSP00000327323,9606.ENSP00000327589,9606.ENSP00000327916,9606.ENSP00000329452,9606.ENSP00000333019,9606.ENSP00000333664,9606.ENSP00000333666,9606.ENSP00000333667,9606.ENSP00000334437,96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.ENSP00000478561,9606.ENSP00000479130,9606.ENSP00000480004,9606.ENSP00000480439,9606.ENSP00000480703,9606.ENSP00000481006,9606.ENSP00000481127,9606.ENSP00000481732,9606.ENSP00000482027,9606.ENSP00000482032,9606.ENSP00000482639,9606.ENSP00000483403,9606.ENSP00000483507,9606.ENSP00000484592
## 24 9606.ENSP00000017003,9606.ENSP00000035307,9606.ENSP00000039007,9606.ENSP00000202967,9606.ENSP00000207870,9606.ENSP00000216180,9606.ENSP00000216465,9606.ENSP00000216605,9606.ENSP00000216951,9606.ENSP00000217426,9606.ENSP00000219345,9606.ENSP00000219481,9606.ENSP00000220764,9606.ENSP00000221700,9606.ENSP00000221930,9606.ENSP00000222115,9606.ENSP00000222982,9606.ENSP00000223026,9606.ENSP00000223029,9606.ENSP00000226253,9606.ENSP00000228476,9606.ENSP00000229239,9606.ENSP00000229416,9606.ENSP00000229447,9606.ENSP00000229583,9606.ENSP00000231420,9606.ENSP00000231887,9606.ENSP00000232219,9606.ENSP00000234111,9606.ENSP00000234677,9606.ENSP00000235345,9606.ENSP00000236959,9606.ENSP00000242592,9606.ENSP00000243167,9606.ENSP00000244137,9606.ENSP00000244217,9606.ENSP00000244527,9606.ENSP00000251566,9606.ENSP00000253382,9606.ENSP00000253801,9606.ENSP00000254190,9606.ENSP00000254878,9606.ENSP00000255192,9606.ENSP00000255389,9606.ENSP00000256999,9606.ENSP00000258494,9606.ENSP00000260118,9606.ENSP00000261434,9606.ENSP00000261507,9606.ENSP00000261596,9606.ENSP00000261714,9606.ENSP00000261772,9606.ENSP00000261835,9606.ENSP00000262288,9606.ENSP00000262290,9606.ENSP00000263035,9606.ENSP00000263038,9606.ENSP00000263080,9606.ENSP00000263317,9606.ENSP00000263383,9606.ENSP00000263980,9606.ENSP00000263985,9606.ENSP00000264784,9606.ENSP00000264914,9606.ENSP00000264932,9606.ENSP00000264990,9606.ENSP00000265113,9606.ENSP00000265174,9606.ENSP00000265372,9606.ENSP00000265395,9606.ENSP00000265605,9606.ENSP00000265838,9606.ENSP00000266736,9606.ENSP00000267436,9606.ENSP00000267842,9606.ENSP00000269848,9606.ENSP00000273450,9606.ENSP00000274353,9606.ENSP00000274813,9606.ENSP00000276055,9606.ENSP00000276651,9606.ENSP00000278618,9606.ENSP00000278840,9606.ENSP00000281182,9606.ENSP00000281243,9606.ENSP00000281317,9606.ENSP00000283871,9606.ENSP00000285093,9606.ENSP00000286298,9606.ENSP00000286733,9606.ENSP00000287143,9606.ENSP00000289004,9606.ENSP00000289416,9606.ENSP00000290429,9606.ENSP00000291670,9606.ENSP00000293217,9606.ENSP00000293404,9606.ENSP00000294973,9606.ENSP00000295256,9606.ENSP00000296424,9606.ENSP00000296522,9606.ENSP00000298198,9606.ENSP00000298248,9606.ENSP00000299022,9606.ENSP00000299299,9606.ENSP00000300051,9606.ENSP00000300079,9606.ENSP00000300784,9606.ENSP00000301175,9606.ENSP00000301729,9606.ENSP00000301891,9606.ENSP00000302620,9606.ENSP00000302851,9606.ENSP00000303246,9606.ENSP00000303356,9606.ENSP00000304440,9606.ENSP00000305221,9606.ENSP00000306459,9606.ENSP00000307188,9606.ENSP00000307297,9606.ENSP00000307697,9606.ENSP00000307900,9606.ENSP00000307911,9606.ENSP00000309477,9606.ENSP00000310565,9606.ENSP00000310688,9606.ENSP00000311224,9606.ENSP00000312250,9606.ENSP00000312652,9606.ENSP00000312987,9606.ENSP00000313377,9606.ENSP00000313432,9606.ENSP00000315644,9606.ENSP00000317721,9606.ENSP00000317842,9606.ENSP00000318351,9606.ENSP00000318867,9606.ENSP00000319501,9606.ENSP00000319622,9606.ENSP00000319814,9606.ENSP00000320309,9606.ENSP00000320401,9606.ENSP00000321424,9606.ENSP00000321874,9606.ENSP00000323071,9606.ENSP00000323811,9606.ENSP00000324105,9606.ENSP00000324343,9606.ENSP00000324648,9606.ENSP00000327323,9606.ENSP00000327589,9606.ENSP00000327916,9606.ENSP00000329452,9606.ENSP00000333019,9606.ENSP00000333664,9606.ENSP00000333666,9606.ENSP00000333667,9606.ENSP00000335304,9606.ENSP00000335620,9606.ENSP00000337425,9606.ENSP00000339933,9606.ENSP00000342385,9606.ENSP00000343657,9606.ENSP00000345282,9606.ENSP00000345771,9606.ENSP00000345974,9606.ENSP00000346693,9606.ENSP00000346964,9606.ENSP00000347041,9606.ENSP00000348429,9606.ENSP00000348459,9606.ENSP00000350012,9606.ENSP00000351190,9606.ENSP00000352706,9606.ENSP00000354238,9606.ENSP00000354612,9606.ENSP00000354721,9606.ENSP00000355308,9606.ENSP00000355493,9606.ENSP00000355517,9606.ENSP00000355518,9606.ENSP00000355880,9606.ENSP00000356047,9606.ENSP00000356070,9606.ENSP00000356104,9606.ENSP00000356438,9606.ENSP00000356820,9606.ENSP00000356864,9606.ENSP00000356905,9606.ENSP00000357535,9606.ENSP00000357787,9606.ENSP00000357807,9606.ENSP00000357838,9606.ENSP00000357873,9606.ENSP00000357920,9606.ENSP00000358060,9606.ENSP00000358417,9606.ENSP00000359478,9606.ENSP00000359680,9606.ENSP00000359871,9606.ENSP00000359976,9606.ENSP00000360124,9606.ENSP00000360170,9606.ENSP00000360317,9606.ENSP00000360327,9606.ENSP00000360541,9606.ENSP00000360569,9606.ENSP00000360577,9606.ENSP00000360715,9606.ENSP00000361140,9606.ENSP00000361151,9606.ENSP00000361287,9606.ENSP00000361471,9606.ENSP00000361894,9606.ENSP00000362207,9606.ENSP00000362608,9606.ENSP00000362817,9606.ENSP00000362888,9606.ENSP00000363216,9606.ENSP00000363533,9606.ENSP00000363590,9606.ENSP00000363614,9606.ENSP00000363645,9606.ENSP00000363794,9606.ENSP00000363988,9606.ENSP00000364490,9606.ENSP00000364649,9606.ENSP00000364883,9606.ENSP00000364907,9606.ENSP00000364986,9606.ENSP00000365601,9606.ENSP00000365773,9606.ENSP00000365908,9606.ENSP00000366030,9606.ENSP00000366243,9606.ENSP00000366797,9606.ENSP00000367086,9606.ENSP00000367923,96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## 25 9606.ENSP00000017003,9606.ENSP00000035307,9606.ENSP00000039007,9606.ENSP00000202967,9606.ENSP00000207870,9606.ENSP00000216180,9606.ENSP00000216465,9606.ENSP00000216605,9606.ENSP00000216951,9606.ENSP00000217426,9606.ENSP00000219345,9606.ENSP00000219481,9606.ENSP00000220764,9606.ENSP00000221700,9606.ENSP00000221930,9606.ENSP00000222115,9606.ENSP00000222982,9606.ENSP00000223026,9606.ENSP00000223029,9606.ENSP00000226253,9606.ENSP00000228476,9606.ENSP00000229239,9606.ENSP00000229416,9606.ENSP00000229447,9606.ENSP00000229583,9606.ENSP00000231420,9606.ENSP00000231887,9606.ENSP00000232219,9606.ENSP00000234111,9606.ENSP00000234677,9606.ENSP00000235345,9606.ENSP00000236959,9606.ENSP00000242592,9606.ENSP00000243167,9606.ENSP00000244137,9606.ENSP00000244217,9606.ENSP00000251566,9606.ENSP00000253382,9606.ENSP00000254190,9606.ENSP00000254878,9606.ENSP00000255192,9606.ENSP00000255389,9606.ENSP00000256999,9606.ENSP00000258494,9606.ENSP00000260118,9606.ENSP00000261434,9606.ENSP00000261507,9606.ENSP00000261596,9606.ENSP00000261714,9606.ENSP00000261772,9606.ENSP00000261835,9606.ENSP00000262288,9606.ENSP00000263035,9606.ENSP00000263038,9606.ENSP00000263080,9606.ENSP00000263317,9606.ENSP00000263383,9606.ENSP00000263980,9606.ENSP00000263985,9606.ENSP00000264914,9606.ENSP00000264932,9606.ENSP00000264990,9606.ENSP00000265113,9606.ENSP00000265174,9606.ENSP00000265372,9606.ENSP00000265395,9606.ENSP00000265605,9606.ENSP00000265838,9606.ENSP00000266736,9606.ENSP00000267436,9606.ENSP00000267842,9606.ENSP00000269848,9606.ENSP00000273450,9606.ENSP00000274353,9606.ENSP00000274813,9606.ENSP00000276055,9606.ENSP00000276651,9606.ENSP00000278618,9606.ENSP00000278840,9606.ENSP00000281182,9606.ENSP00000281243,9606.ENSP00000281317,9606.ENSP00000283871,9606.ENSP00000285093,9606.ENSP00000286298,9606.ENSP00000286733,9606.ENSP00000287143,9606.ENSP00000289004,9606.ENSP00000289416,9606.ENSP00000290429,9606.ENSP00000291670,9606.ENSP00000293217,9606.ENSP00000293404,9606.ENSP00000294973,9606.ENSP00000295256,9606.ENSP00000296424,9606.ENSP00000296522,9606.ENSP00000298198,9606.ENSP00000298248,9606.ENSP00000299022,9606.ENSP00000299299,9606.ENSP00000300051,9606.ENSP00000300079,9606.ENSP00000300784,9606.ENSP00000301175,9606.ENSP00000301729,9606.ENSP00000302620,9606.ENSP00000302851,9606.ENSP00000303246,9606.ENSP00000303356,9606.ENSP00000304440,9606.ENSP00000305221,9606.ENSP00000306459,9606.ENSP00000307188,9606.ENSP00000307297,9606.ENSP00000307697,9606.ENSP00000307900,9606.ENSP00000307911,9606.ENSP00000309477,9606.ENSP00000310565,9606.ENSP00000310688,9606.ENSP00000311224,9606.ENSP00000312250,9606.ENSP00000312652,9606.ENSP00000312987,9606.ENSP00000313377,9606.ENSP00000313432,9606.ENSP00000315644,9606.ENSP00000317721,9606.ENSP00000317842,9606.ENSP00000318351,9606.ENSP00000318867,9606.ENSP00000319501,9606.ENSP00000319622,9606.ENSP00000319814,9606.ENSP00000320309,9606.ENSP00000320401,9606.ENSP00000321424,9606.ENSP00000321874,9606.ENSP00000323071,9606.ENSP00000323811,9606.ENSP00000324105,9606.ENSP00000324343,9606.ENSP00000324648,9606.ENSP00000327323,9606.ENSP00000327589,9606.ENSP00000327916,9606.ENSP00000329452,9606.ENSP00000333019,9606.ENSP00000333664,9606.ENSP00000333666,9606.ENSP00000333667,9606.ENSP00000335304,9606.ENSP00000335620,9606.ENSP00000337425,9606.ENSP00000339933,9606.ENSP00000342385,9606.ENSP00000343657,9606.ENSP00000345282,9606.ENSP00000345771,9606.ENSP00000345974,9606.ENSP00000346693,9606.ENSP00000346964,9606.ENSP00000347041,9606.ENSP00000348429,9606.ENSP00000348459,9606.ENSP00000350012,9606.ENSP00000351190,9606.ENSP00000352706,9606.ENSP00000354238,9606.ENSP00000354612,9606.ENSP00000354721,9606.ENSP00000355308,9606.ENSP00000355493,9606.ENSP00000355517,9606.ENSP00000355518,9606.ENSP00000355880,9606.ENSP00000356047,9606.ENSP00000356070,9606.ENSP00000356104,9606.ENSP00000356438,9606.ENSP00000356820,9606.ENSP00000356864,9606.ENSP00000356905,9606.ENSP00000357535,9606.ENSP00000357787,9606.ENSP00000357807,9606.ENSP00000357838,9606.ENSP00000357873,9606.ENSP00000357920,9606.ENSP00000358060,9606.ENSP00000358417,9606.ENSP00000359478,9606.ENSP00000359680,9606.ENSP00000359871,9606.ENSP00000359976,9606.ENSP00000360124,9606.ENSP00000360170,9606.ENSP00000360317,9606.ENSP00000360327,9606.ENSP00000360541,9606.ENSP00000360569,9606.ENSP00000360577,9606.ENSP00000360715,9606.ENSP00000361140,9606.ENSP00000361151,9606.ENSP00000361287,9606.ENSP00000361471,9606.ENSP00000361894,9606.ENSP00000362207,9606.ENSP00000362608,9606.ENSP00000362817,9606.ENSP00000362888,9606.ENSP00000363216,9606.ENSP00000363533,9606.ENSP00000363590,9606.ENSP00000363614,9606.ENSP00000363645,9606.ENSP00000363794,9606.ENSP00000363988,9606.ENSP00000364490,9606.ENSP00000364649,9606.ENSP00000364883,9606.ENSP00000364907,9606.ENSP00000364986,9606.ENSP00000365601,9606.ENSP00000365773,9606.ENSP00000365908,9606.ENSP00000366030,9606.ENSP00000366243,9606.ENSP00000367086,9606.ENSP00000367923,9606.ENSP00000368079,9606.ENSP00000368517,9606.ENSP00000369014,9606.ENSP00000369461,9606.ENSP00000369739,9606.ENSP00000369927,9606.ENSP00000370531,9606.ENSP00000370737,9606.ENSP00000371110,9606.ENSP00000371253,9606.ENSP00000376293,9606.ENSP00000376807,9606.ENSP00000377040,9606.ENSP00000377303,9606.ENSP00000377532,9606.ENSP00000377696,9606.ENSP00000378177,9606.ENSP00000378359,9606.ENSP00000378782,9606.ENSP00000378854,9606.ENSP00000379845,9606.ENSP00000379895,9606.ENSP00000380184,9606.ENSP00000380365,9606.ENSP00000384588,9606.ENSP00000385080,9606.ENSP00000385523,9606.ENSP00000385828,9606.ENSP00000387123,9606.ENSP00000387654,9606.ENSP00000389813,9606.ENSP00000390265,9606.ENSP00000392762,9606.ENSP00000395535,9606.ENSP00000399421,9606.ENSP00000399585,9606.ENSP00000400870,9606.ENSP00000400995,9606.ENSP00000401831,9606.ENSP00000402103,9606.ENSP00000402394,9606.ENSP00000403644,9606.ENSP00000411816,9606.ENSP00000418397,9606.ENSP00000418669,9606.ENSP00000418960,9606.ENSP00000419027,9606.ENSP00000419325,9606.ENSP00000420065,9606.ENSP00000420914,9606.ENSP00000423674,9606.ENSP00000430269,9606.ENSP00000436585,9606.ENSP00000437402,9606.ENSP00000438144,9606.ENSP00000443432,9606.ENSP00000448059,9606.ENSP00000448998,9606.ENSP00000450436,9606.ENSP00000452762,9606.ENSP00000455459,9606.ENSP00000459451,9606.ENSP00000472546,9606.ENSP00000474560,9606.ENSP00000477567,9606.ENSP00000478561,9606.ENSP00000479130,9606.ENSP00000480004,9606.ENSP00000480703,9606.ENSP00000481006,9606.ENSP00000481127,9606.ENSP00000482027,9606.ENSP00000482639,9606.ENSP00000483507,9606.ENSP00000484592
## 26 9606.ENSP00000039007,9606.ENSP00000202967,9606.ENSP00000207870,9606.ENSP00000216180,9606.ENSP00000216465,9606.ENSP00000216605,9606.ENSP00000216951,9606.ENSP00000217426,9606.ENSP00000219345,9606.ENSP00000219481,9606.ENSP00000220764,9606.ENSP00000221700,9606.ENSP00000221930,9606.ENSP00000222115,9606.ENSP00000222982,9606.ENSP00000223029,9606.ENSP00000226253,9606.ENSP00000228476,9606.ENSP00000229239,9606.ENSP00000229416,9606.ENSP00000229447,9606.ENSP00000229583,9606.ENSP00000231420,9606.ENSP00000231887,9606.ENSP00000232219,9606.ENSP00000234111,9606.ENSP00000234677,9606.ENSP00000235345,9606.ENSP00000236959,9606.ENSP00000242592,9606.ENSP00000243167,9606.ENSP00000244137,9606.ENSP00000244217,9606.ENSP00000251566,9606.ENSP00000253382,9606.ENSP00000254878,9606.ENSP00000255192,9606.ENSP00000255389,9606.ENSP00000256999,9606.ENSP00000258494,9606.ENSP00000260118,9606.ENSP00000261434,9606.ENSP00000261507,9606.ENSP00000261596,9606.ENSP00000261714,9606.ENSP00000261772,9606.ENSP00000261835,9606.ENSP00000262288,9606.ENSP00000263035,9606.ENSP00000263038,9606.ENSP00000263080,9606.ENSP00000263317,9606.ENSP00000263383,9606.ENSP00000263980,9606.ENSP00000263985,9606.ENSP00000264932,9606.ENSP00000264990,9606.ENSP00000265113,9606.ENSP00000265372,9606.ENSP00000265395,9606.ENSP00000265605,9606.ENSP00000265838,9606.ENSP00000266736,9606.ENSP00000267436,9606.ENSP00000267842,9606.ENSP00000269848,9606.ENSP00000273450,9606.ENSP00000274353,9606.ENSP00000274813,9606.ENSP00000276651,9606.ENSP00000278618,9606.ENSP00000278840,9606.ENSP00000281182,9606.ENSP00000281243,9606.ENSP00000281317,9606.ENSP00000283871,9606.ENSP00000285093,9606.ENSP00000286733,9606.ENSP00000287143,9606.ENSP00000289004,9606.ENSP00000289416,9606.ENSP00000290429,9606.ENSP00000291670,9606.ENSP00000293217,9606.ENSP00000293404,9606.ENSP00000294973,9606.ENSP00000295256,9606.ENSP00000296424,9606.ENSP00000296522,9606.ENSP00000298198,9606.ENSP00000298248,9606.ENSP00000299022,9606.ENSP00000299299,9606.ENSP00000300051,9606.ENSP00000300079,9606.ENSP00000300784,9606.ENSP00000301175,9606.ENSP00000301729,9606.ENSP00000302620,9606.ENSP00000302851,9606.ENSP00000303246,9606.ENSP00000303356,9606.ENSP00000304440,9606.ENSP00000305221,9606.ENSP00000307188,9606.ENSP00000307297,9606.ENSP00000307697,9606.ENSP00000307900,9606.ENSP00000309477,9606.ENSP00000310565,9606.ENSP00000310688,9606.ENSP00000311224,9606.ENSP00000312250,9606.ENSP00000312652,9606.ENSP00000312987,9606.ENSP00000313377,9606.ENSP00000313432,9606.ENSP00000315644,9606.ENSP00000317721,9606.ENSP00000317842,9606.ENSP00000318351,9606.ENSP00000318867,9606.ENSP00000319501,9606.ENSP00000319814,9606.ENSP00000320309,9606.ENSP00000320401,9606.ENSP00000321424,9606.ENSP00000323071,9606.ENSP00000323811,9606.ENSP00000324105,9606.ENSP00000324343,9606.ENSP00000324648,9606.ENSP00000327323,9606.ENSP00000327589,9606.ENSP00000327916,9606.ENSP00000329452,9606.ENSP00000333019,9606.ENSP00000333664,9606.ENSP00000333666,9606.ENSP00000333667,9606.ENSP00000335304,9606.ENSP00000335620,9606.ENSP00000337425,9606.ENSP00000339933,9606.ENSP00000342385,9606.ENSP00000343657,9606.ENSP00000345282,9606.ENSP00000345771,9606.ENSP00000345974,9606.ENSP00000346693,9606.ENSP00000348429,9606.ENSP00000348459,9606.ENSP00000350012,9606.ENSP00000351190,9606.ENSP00000352706,9606.ENSP00000354612,9606.ENSP00000355308,9606.ENSP00000355493,9606.ENSP00000355517,9606.ENSP00000355518,9606.ENSP00000356047,9606.ENSP00000356070,9606.ENSP00000356104,9606.ENSP00000356438,9606.ENSP00000356820,9606.ENSP00000356864,9606.ENSP00000356905,9606.ENSP00000357535,9606.ENSP00000357787,9606.ENSP00000357807,9606.ENSP00000357838,9606.ENSP00000357873,9606.ENSP00000357920,9606.ENSP00000358060,9606.ENSP00000358417,9606.ENSP00000359478,9606.ENSP00000359680,9606.ENSP00000359871,9606.ENSP00000359976,9606.ENSP00000360124,9606.ENSP00000360170,9606.ENSP00000360317,9606.ENSP00000360327,9606.ENSP00000360541,9606.ENSP00000360569,9606.ENSP00000360577,9606.ENSP00000360715,9606.ENSP00000361140,9606.ENSP00000361151,9606.ENSP00000361287,9606.ENSP00000361471,9606.ENSP00000361894,9606.ENSP00000362608,9606.ENSP00000362817,9606.ENSP00000362888,9606.ENSP00000363216,9606.ENSP00000363533,9606.ENSP00000363614,9606.ENSP00000363645,9606.ENSP00000363794,9606.ENSP00000363988,9606.ENSP00000364490,9606.ENSP00000364649,9606.ENSP00000364883,9606.ENSP00000364907,9606.ENSP00000364986,9606.ENSP00000365601,9606.ENSP00000365773,9606.ENSP00000366030,9606.ENSP00000366243,9606.ENSP00000367086,9606.ENSP00000367923,9606.ENSP00000368079,9606.ENSP00000368517,9606.ENSP00000369461,9606.ENSP00000369739,9606.ENSP00000369927,9606.ENSP00000370531,9606.ENSP00000370737,9606.ENSP00000371110,9606.ENSP00000371253,9606.ENSP00000376293,9606.ENSP00000376807,9606.ENSP00000377040,9606.ENSP00000377303,9606.ENSP00000377532,9606.ENSP00000377696,9606.ENSP00000378177,9606.ENSP00000378359,9606.ENSP00000378782,9606.ENSP00000378854,9606.ENSP00000379845,9606.ENSP00000379895,9606.ENSP00000380184,9606.ENSP00000380365,9606.ENSP00000384588,9606.ENSP00000385080,9606.ENSP00000385523,9606.ENSP00000385828,9606.ENSP00000387123,9606.ENSP00000387654,9606.ENSP00000389813,9606.ENSP00000390265,9606.ENSP00000392762,9606.ENSP00000395535,9606.ENSP00000399421,9606.ENSP00000399585,9606.ENSP00000400870,9606.ENSP00000400995,9606.ENSP00000401831,9606.ENSP00000402103,9606.ENSP00000403644,9606.ENSP00000411816,9606.ENSP00000418397,9606.ENSP00000418669,9606.ENSP00000418960,9606.ENSP00000419027,9606.ENSP00000419325,9606.ENSP00000420914,9606.ENSP00000423674,9606.ENSP00000430269,9606.ENSP00000436585,9606.ENSP00000437402,9606.ENSP00000438144,9606.ENSP00000443432,9606.ENSP00000448059,9606.ENSP00000448998,9606.ENSP00000450436,9606.ENSP00000452762,9606.ENSP00000455459,9606.ENSP00000459451,9606.ENSP00000472546,9606.ENSP00000474560,9606.ENSP00000477567,9606.ENSP00000478561,9606.ENSP00000479130,9606.ENSP00000480004,9606.ENSP00000480703,9606.ENSP00000481006,9606.ENSP00000481127,9606.ENSP00000482027,9606.ENSP00000482639,9606.ENSP00000483507,9606.ENSP00000484592
## 27 9606.ENSP00000039007,9606.ENSP00000207870,9606.ENSP00000216465,9606.ENSP00000216862,9606.ENSP00000217426,9606.ENSP00000219345,9606.ENSP00000219481,9606.ENSP00000220764,9606.ENSP00000221403,9606.ENSP00000221700,9606.ENSP00000221930,9606.ENSP00000226253,9606.ENSP00000228476,9606.ENSP00000228606,9606.ENSP00000229239,9606.ENSP00000229583,9606.ENSP00000231420,9606.ENSP00000231887,9606.ENSP00000233575,9606.ENSP00000242592,9606.ENSP00000243167,9606.ENSP00000244217,9606.ENSP00000251108,9606.ENSP00000252486,9606.ENSP00000254878,9606.ENSP00000257770,9606.ENSP00000258494,9606.ENSP00000260599,9606.ENSP00000261596,9606.ENSP00000261714,9606.ENSP00000261835,9606.ENSP00000263038,9606.ENSP00000263080,9606.ENSP00000263383,9606.ENSP00000263980,9606.ENSP00000264990,9606.ENSP00000265395,9606.ENSP00000265605,9606.ENSP00000265838,9606.ENSP00000266736,9606.ENSP00000267842,9606.ENSP00000269159,9606.ENSP00000269848,9606.ENSP00000272252,9606.ENSP00000273450,9606.ENSP00000274813,9606.ENSP00000276651,9606.ENSP00000281182,9606.ENSP00000281243,9606.ENSP00000281317,9606.ENSP00000283871,9606.ENSP00000285093,9606.ENSP00000289004,9606.ENSP00000290429,9606.ENSP00000291670,9606.ENSP00000293217,9606.ENSP00000294973,9606.ENSP00000296424,9606.ENSP00000298198,9606.ENSP00000298248,9606.ENSP00000299299,9606.ENSP00000300051,9606.ENSP00000301175,9606.ENSP00000301729,9606.ENSP00000302620,9606.ENSP00000303356,9606.ENSP00000303575,9606.ENSP00000306817,9606.ENSP00000307697,9606.ENSP00000307900,9606.ENSP00000309749,9606.ENSP00000310688,9606.ENSP00000312250,9606.ENSP00000312652,9606.ENSP00000313398,9606.ENSP00000317721,9606.ENSP00000318351,9606.ENSP00000319814,9606.ENSP00000323071,9606.ENSP00000323811,9606.ENSP00000324105,9606.ENSP00000324343,9606.ENSP00000327323,9606.ENSP00000327589,9606.ENSP00000329452,9606.ENSP00000333664,9606.ENSP00000333667,9606.ENSP00000335246,9606.ENSP00000335304,9606.ENSP00000337425,9606.ENSP00000339933,9606.ENSP00000343657,9606.ENSP00000345282,9606.ENSP00000345771,9606.ENSP00000345974,9606.ENSP00000347792,9606.ENSP00000348459,9606.ENSP00000351520,9606.ENSP00000352706,9606.ENSP00000355517,9606.ENSP00000356047,9606.ENSP00000357535,9606.ENSP00000357583,9606.ENSP00000357838,9606.ENSP00000357873,9606.ENSP00000357920,9606.ENSP00000359680,9606.ENSP00000359871,9606.ENSP00000359976,9606.ENSP00000360124,9606.ENSP00000360250,9606.ENSP00000360541,9606.ENSP00000360569,9606.ENSP00000360577,9606.ENSP00000361140,9606.ENSP00000361151,9606.ENSP00000361287,9606.ENSP00000362888,9606.ENSP00000363614,9606.ENSP00000363988,9606.ENSP00000364490,9606.ENSP00000364883,9606.ENSP00000365601,9606.ENSP00000366030,9606.ENSP00000366243,9606.ENSP00000366927,9606.ENSP00000369461,9606.ENSP00000369927,9606.ENSP00000370737,9606.ENSP00000371110,9606.ENSP00000373674,9606.ENSP00000376142,9606.ENSP00000377040,9606.ENSP00000377303,9606.ENSP00000378177,9606.ENSP00000378360,9606.ENSP00000378782,9606.ENSP00000379845,9606.ENSP00000384588,9606.ENSP00000385080,9606.ENSP00000385828,9606.ENSP00000387123,9606.ENSP00000387498,9606.ENSP00000387654,9606.ENSP00000389175,9606.ENSP00000389813,9606.ENSP00000402103,9606.ENSP00000416583,9606.ENSP00000418397,9606.ENSP00000419027,9606.ENSP00000420914,9606.ENSP00000422375,9606.ENSP00000423674,9606.ENSP00000436585,9606.ENSP00000437402,9606.ENSP00000439689,9606.ENSP00000443432,9606.ENSP00000448059,9606.ENSP00000448998,9606.ENSP00000450436,9606.ENSP00000452762,9606.ENSP00000455459,9606.ENSP00000474090,9606.ENSP00000474560,9606.ENSP00000477567,9606.ENSP00000479130,9606.ENSP00000481127,9606.ENSP00000483507
## 28 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## preferredNames
## 23 FUCA2,XYLT2,CHPF2,OTC,CETP,SIRT4,XYLB,MAPK1,TCN2,SLC25A1,PNPLA3,PMM1,GSTZ1,MTHFD1,CYP24A1,GSS,SLC52A3,AHCY,DHODH,PLA2G15,DECR2,DECR1,DHDH,CYP4F2,TGFB1,HAS1,CYP3A5,HYAL4,AIMP2,MOGAT3,SFXN3,PNPO,ALDOC,DAO,CYP27B1,GAPDH,GCLC,IYD,ADTRP,ACOT13,DNPH1,AGXT2,EHHADH,RBP1,SNX17,ODC1,SARS,SLC35D1,AKR7A2,ATIC,GDA,PANK3,ACADS,FAAH,PEPD,MCEE,SLC17A1,MBD4,CDADC1,UGT2A3,APOE,ACSS2,G6PC,CHSY1,HRSP12,BHMT2,PEMT,MACROD1,FOLH1,NT5E,BCO1,SLC19A3,ALDH1L2,GMPR,TTPA,GGH,KHK,ADCY3,GUCY2C,LIAS,MSMO1,LPIN2,BLMH,AARS,CYP46A1,SCPEP1,LPO,DHTKD1,PHYH,ASPA,NOX4,ILVBL,LRP2,SLC9A1,GATB,GUCY1B3,PPAP2A,SLC2A9,ARSB,SDHA,ACAD11,SLC1A3,PAPSS1,CREM,HIBADH,ALDH8A1,ACAT1,REXO2,PLCZ1,AMDHD1,L2HGDH,AK7,SLC27A2,RLBP1,PRPSAP2,IMPA2,PFKL,GALM,ALDH1L1,BHMT,MUT,CHST7,ERLIN2,DPYS,FUOM,AASDHPPT,FADS2,TM7SF2,ACAD8,QDPR,MMAA,HGD,NEIL2,ACAA2,CA2,SLC26A2,ADK,DCK,NAAA,PRG3,NMNAT2,IPPK,THTPA,COQ5,HPD,ACSM3,MCAT,CALM3,FTCD,FLAD1,ACOX1,NAGS,ADCY9,HAAO,HPGDS,BDH2,HPGD,PGM2L1,CRYL1,LRRK2,LIPC,AMN,PCBD1,TK2,LDHD,GLYATL1,ATP5L,FN3K,GPD1,PRODH2,ACER1,ATP5H,ECI1,SLC22A11,PANK1,KBTBD2,AGXT,ONECUT1,SLC23A1,ACOT12,DCXR,NUDT9,HAS3,UGT2B4,B4GALT6,OGG1,RBKS,ASL,CHST14,ACOX2,GLUL,CHST2,ACO1,APOBEC3F,SLC22A13,DSEL,ABCD2,ACOT1,PDE8A,CARKD,ADPGK,LEP,HNF4A,PANK2,FUT6,GRHPR,GBA,TYMS,SFXN1,PIPOX,CES2,MPI,BCKDHB,PRTFDC1,CYP8B1,UGDH,SULT1C2,PCK1,FARSA,PLA2G16,UGT2B17,SLC34A1,B3GNT3,DPM2,ACOT4,HACL1,ENO3,UPB1,CYP2B6,THNSL2,GLUD2,ACSM5,SLC25A21,ADSSL1,ACAA1,ADI1,SHMT2,NUDT17,ENTPD5,DLST,GSTA1,LRAT,HYAL3,STARD3,NT5C2,LBR,PKLR,NISCH,SMPD1,NMNAT3,PTGES,MCCC2,ATF3,INSIG1,GPT2,PFKM,ENOSF1,ELOVL2,EGFLAM,FMOD,PDE5A,SYNJ2,ACSL5,ACMSD,STOML2,ACSL3,ITIH2,ENTPD4,HIBCH,SLC39A14,ENPP1,PPT2,PTGS1,SLC26A1,ABCG1,PTPLA,ADSS,KMO,FH,MARC2,PFKFB2,MAPKAPK2,PM20D1,PTGS2,LHX4-AS1,MPC2,MGST3,UAP1,VNN1,APOA2,USF1,SMPDL3A,PMVK,ECHS1,INPP5A,NPR1,UROS,THEM5,LHPP,OAT,ACADSB,DDO,PDSS2,TARS2,HMGCS2,PHGDH,GNAI3,CYP17A1,ABCC2,HOGA1,ACADM,CTH,PGM1,ANGPTL3,ENTPD1,FGGY,CYP2C8,PARS2,PLCE1,RBP4,CPT2,SCP2,ECHDC2,TMEM189,AKR1A1,CEL,MAT1A,ASS1,PPCS,GNMT,CHST3,PIM1,FABP3,ADO,NFS1,OGDHL,MDH1B,CSGALNACT2,HMGCL,TXN,AWAT1,HSD17B8,AOX1,ALDOB,ALDH4A1,SDHB,AUH,SYK,AGMAT,PDSS1,IDNK,PSAT1,PRUNE2,RFK,C9orf41,TMEM2,CA6,SLC22A12,ALDH1B1,CUBN,ACOT7,SUCLA2,CYP4V2,ECHDC3,ACOT9,NDNF,GLRX,ECI2,BPHL,AKR1C3,PDE4A,PDX1,PNPLA4,ACOT6,GLDC,RDH11,GCAT,GART,NT5M,INPP1,OSBPL6,NUDT14,DPEP1,LGMN,AASS,RENBP,PC,NIT2,CEMIP,ADH6,DAK,DNAJC30,AK4,SLC16A9,QPRT,PSPH,AMPD3,ABAT,GATM,AGPAT6,SLC17A3,RGN,ATP5A1,SPTLC3,PARG,CYP4F11,FAH,PPARA,TST,KDM3A,ALDH7A1,FUT2,PCYOX1,PLCD4,GLYCTK,ACAD10,IDH1,DCT,PPT1,MECP2,IP6K3,CD36,MRS2,SLC25A13,AARSD1,OTOGL,BTD,ACSF2,HK1,CHST15,DDC,CA10,ENPP3,FBP1,ITPKB,CSGALNACT1,DERA,PLTP,FHIT,IVD,MME,SEPHS2,BRCA1,PCCB,SUCLG2,ABHD14B,HSD17B4,PDK2,NUDT16,GNPDA1,EPHX2,ECHDC1,ENO2,MDH1,PDE10A,TRERF1,FAR2,IDO2,SLC5A8,MMAB,PAH,CYP4F12,RDH12,ACSS3,ALDH6A1,ETFA,GALK2,HYKK,ACSM2A,ENSP00000461324,RDH8,ACP5,PLA2G4C,UPP2,HADH,CYP4F8,CYP1B1,ACSF3,EPHX1,DHRS3,SLC46A1,PLP1,PRODH,FMO1,NR4A3,IP6K1,MGST2,GHR,HAO2,GLYAT
## 24 XYLT2,CHPF2,OTC,SIRT4,XYLB,PNPLA3,GSTZ1,MTHFD1,GSS,AHCY,PLA2G15,DECR2,DECR1,CYP4F2,TGFB1,HAS1,CYP3A5,HYAL4,AIMP2,ALDOC,DAO,GAPDH,GCLC,IYD,ADTRP,AGXT2,EHHADH,RBP1,ODC1,SARS,SLC35D1,ATIC,ACADS,FAAH,PEPD,MCEE,SLC17A1,UGT2A3,ACSS2,G6PC,CHSY1,HRSP12,BHMT2,PEMT,FOLH1,ALDH1L2,GGH,LIAS,MSMO1,LPIN2,BLMH,AARS,CYP46A1,SCPEP1,LPO,DHTKD1,PHYH,ASPA,NOX4,ILVBL,SLC9A1,GATB,SLC2A9,ARSB,SDHA,ACAD11,SLC1A3,PAPSS1,CREM,HIBADH,ALDH8A1,ACAT1,AMDHD1,L2HGDH,SLC27A2,PFKL,ALDH1L1,BHMT,MUT,CHST7,DPYS,AASDHPPT,FADS2,ACAD8,QDPR,MMAA,HGD,ACAA2,SLC26A2,NAAA,PRG3,HPD,ACSM3,MCAT,FTCD,ACOX1,NAGS,HAAO,HPGDS,BDH2,HPGD,PGM2L1,CRYL1,LIPC,PCBD1,LDHD,GLYATL1,FN3K,PRODH2,ECI1,SLC22A11,AGXT,SLC23A1,ACOT12,DCXR,HAS3,UGT2B4,B4GALT6,ASL,CHST14,ACOX2,GLUL,CHST2,ACO1,DSEL,ABCD2,ACOT1,ADPGK,LEP,HNF4A,PANK2,GRHPR,TYMS,PIPOX,CES2,BCKDHB,CYP8B1,UGDH,SULT1C2,PCK1,FARSA,UGT2B17,SLC34A1,B3GNT3,ACOT4,HACL1,ENO3,UPB1,CYP2B6,THNSL2,GLUD2,ACSM5,SLC25A21,ADSSL1,ACAA1,ADI1,SHMT2,DLST,GSTA1,HYAL3,PKLR,PTGES,MCCC2,GPT2,PFKM,ENOSF1,ELOVL2,EGFLAM,FMOD,ACSL5,ACMSD,ACSL3,ITIH2,HIBCH,ENPP1,PTGS1,SLC26A1,PTPLA,ADSS,KMO,FH,MARC2,PFKFB2,MAPKAPK2,PM20D1,PTGS2,MPC2,MGST3,VNN1,ECHS1,UROS,THEM5,OAT,ACADSB,DDO,TARS2,PHGDH,ABCC2,HOGA1,ACADM,CTH,PGM1,ANGPTL3,CYP2C8,PARS2,CPT2,SCP2,ECHDC2,TMEM189,AKR1A1,CEL,MAT1A,ASS1,GNMT,CHST3,PIM1,FABP3,ADO,OGDHL,MDH1B,CSGALNACT2,HMGCL,AWAT1,HSD17B8,ALDOB,ALDH4A1,SDHB,AUH,SYK,AGMAT,IDNK,PSAT1,PRUNE2,C9orf41,TMEM2,SLC22A12,ACOT7,SUCLA2,CYP4V2,ECHDC3,NDNF,ECI2,BPHL,AKR1C3,ACOT6,GLDC,GCAT,GART,OSBPL6,DPEP1,AASS,RENBP,PC,NIT2,CEMIP,ADH6,SLC16A9,QPRT,PSPH,ABAT,GATM,AGPAT6,SLC17A3,RGN,CYP4F11,FAH,PPARA,TST,ALDH7A1,PCYOX1,ACAD10,IDH1,DCT,MECP2,CD36,MRS2,AARSD1,BTD,ACSF2,HK1,CHST15,DDC,CSGALNACT1,IVD,SEPHS2,BRCA1,PCCB,SUCLG2,ABHD14B,HSD17B4,GNPDA1,EPHX2,ECHDC1,ENO2,MDH1,IDO2,PAH,CYP4F12,ALDH6A1,ETFA,HYKK,ACSM2A,PLA2G4C,HADH,CYP4F8,CYP1B1,ACSF3,EPHX1,SLC46A1,PLP1,PRODH,FMO1,NR4A3,MGST2,GHR,HAO2,GLYAT
## 25 XYLT2,CHPF2,OTC,SIRT4,XYLB,PNPLA3,GSTZ1,MTHFD1,GSS,AHCY,PLA2G15,DECR2,DECR1,CYP4F2,TGFB1,HAS1,CYP3A5,HYAL4,AIMP2,ALDOC,DAO,GAPDH,GCLC,IYD,ADTRP,AGXT2,EHHADH,RBP1,ODC1,SARS,SLC35D1,ATIC,ACADS,FAAH,PEPD,MCEE,UGT2A3,ACSS2,CHSY1,HRSP12,BHMT2,PEMT,FOLH1,ALDH1L2,GGH,LIAS,MSMO1,LPIN2,BLMH,AARS,CYP46A1,SCPEP1,DHTKD1,PHYH,ASPA,NOX4,ILVBL,SLC9A1,GATB,ARSB,SDHA,ACAD11,SLC1A3,PAPSS1,CREM,HIBADH,ALDH8A1,ACAT1,AMDHD1,L2HGDH,SLC27A2,PFKL,ALDH1L1,BHMT,MUT,CHST7,DPYS,AASDHPPT,FADS2,ACAD8,QDPR,MMAA,HGD,ACAA2,SLC26A2,NAAA,PRG3,HPD,ACSM3,MCAT,FTCD,ACOX1,NAGS,HAAO,HPGDS,BDH2,HPGD,PGM2L1,CRYL1,LIPC,PCBD1,LDHD,GLYATL1,FN3K,PRODH2,ECI1,AGXT,SLC23A1,ACOT12,DCXR,HAS3,UGT2B4,B4GALT6,ASL,CHST14,ACOX2,GLUL,CHST2,ACO1,DSEL,ABCD2,ACOT1,ADPGK,LEP,HNF4A,PANK2,GRHPR,TYMS,PIPOX,CES2,BCKDHB,CYP8B1,UGDH,SULT1C2,PCK1,FARSA,UGT2B17,SLC34A1,B3GNT3,ACOT4,HACL1,ENO3,UPB1,CYP2B6,THNSL2,GLUD2,ACSM5,SLC25A21,ADSSL1,ACAA1,ADI1,SHMT2,DLST,GSTA1,HYAL3,PKLR,PTGES,MCCC2,GPT2,PFKM,ENOSF1,ELOVL2,EGFLAM,FMOD,ACSL5,ACMSD,ACSL3,ITIH2,HIBCH,ENPP1,PTGS1,SLC26A1,PTPLA,ADSS,KMO,FH,MARC2,PFKFB2,MAPKAPK2,PM20D1,PTGS2,MPC2,MGST3,VNN1,ECHS1,UROS,THEM5,OAT,ACADSB,DDO,TARS2,PHGDH,ABCC2,HOGA1,ACADM,CTH,PGM1,ANGPTL3,CYP2C8,PARS2,CPT2,SCP2,ECHDC2,TMEM189,AKR1A1,CEL,MAT1A,ASS1,GNMT,CHST3,PIM1,FABP3,ADO,OGDHL,MDH1B,CSGALNACT2,HMGCL,AWAT1,HSD17B8,ALDOB,ALDH4A1,SDHB,AUH,SYK,AGMAT,IDNK,PSAT1,PRUNE2,C9orf41,TMEM2,ACOT7,SUCLA2,CYP4V2,ECHDC3,NDNF,ECI2,BPHL,AKR1C3,ACOT6,GLDC,GCAT,GART,OSBPL6,DPEP1,AASS,RENBP,PC,NIT2,CEMIP,ADH6,QPRT,PSPH,ABAT,GATM,AGPAT6,RGN,CYP4F11,FAH,PPARA,TST,ALDH7A1,PCYOX1,ACAD10,IDH1,DCT,MECP2,CD36,MRS2,AARSD1,BTD,ACSF2,HK1,CHST15,DDC,CSGALNACT1,IVD,SEPHS2,BRCA1,PCCB,SUCLG2,ABHD14B,HSD17B4,GNPDA1,EPHX2,ECHDC1,ENO2,MDH1,IDO2,PAH,CYP4F12,ALDH6A1,ETFA,HYKK,ACSM2A,PLA2G4C,HADH,CYP4F8,CYP1B1,ACSF3,EPHX1,SLC46A1,PLP1,PRODH,NR4A3,MGST2,HAO2,GLYAT
## 26 OTC,SIRT4,XYLB,PNPLA3,GSTZ1,MTHFD1,GSS,AHCY,PLA2G15,DECR2,DECR1,CYP4F2,TGFB1,HAS1,CYP3A5,AIMP2,ALDOC,DAO,GAPDH,GCLC,IYD,ADTRP,AGXT2,EHHADH,RBP1,ODC1,SARS,SLC35D1,ATIC,ACADS,FAAH,PEPD,MCEE,UGT2A3,ACSS2,HRSP12,BHMT2,PEMT,FOLH1,ALDH1L2,GGH,LIAS,MSMO1,LPIN2,BLMH,AARS,CYP46A1,SCPEP1,DHTKD1,PHYH,ASPA,NOX4,ILVBL,SLC9A1,GATB,SDHA,ACAD11,SLC1A3,CREM,HIBADH,ALDH8A1,ACAT1,AMDHD1,L2HGDH,SLC27A2,PFKL,ALDH1L1,BHMT,MUT,DPYS,AASDHPPT,FADS2,ACAD8,QDPR,MMAA,HGD,ACAA2,NAAA,PRG3,HPD,ACSM3,MCAT,FTCD,ACOX1,NAGS,HAAO,HPGDS,BDH2,HPGD,PGM2L1,CRYL1,LIPC,PCBD1,LDHD,GLYATL1,FN3K,PRODH2,ECI1,AGXT,SLC23A1,ACOT12,DCXR,HAS3,UGT2B4,ASL,CHST14,ACOX2,GLUL,ACO1,DSEL,ABCD2,ACOT1,ADPGK,LEP,HNF4A,PANK2,GRHPR,TYMS,PIPOX,CES2,BCKDHB,CYP8B1,UGDH,PCK1,FARSA,UGT2B17,SLC34A1,ACOT4,HACL1,ENO3,UPB1,CYP2B6,THNSL2,GLUD2,ACSM5,SLC25A21,ADSSL1,ACAA1,ADI1,SHMT2,DLST,GSTA1,HYAL3,PKLR,PTGES,MCCC2,GPT2,PFKM,ENOSF1,ELOVL2,ACSL5,ACMSD,ACSL3,ITIH2,HIBCH,PTGS1,PTPLA,ADSS,KMO,FH,PFKFB2,MAPKAPK2,PM20D1,PTGS2,MPC2,MGST3,VNN1,ECHS1,UROS,THEM5,OAT,ACADSB,DDO,TARS2,PHGDH,ABCC2,HOGA1,ACADM,CTH,PGM1,ANGPTL3,CYP2C8,PARS2,CPT2,SCP2,ECHDC2,TMEM189,AKR1A1,CEL,MAT1A,ASS1,GNMT,PIM1,FABP3,ADO,OGDHL,MDH1B,HMGCL,AWAT1,HSD17B8,ALDOB,ALDH4A1,SDHB,AUH,SYK,AGMAT,IDNK,PSAT1,C9orf41,TMEM2,ACOT7,SUCLA2,CYP4V2,ECHDC3,ECI2,BPHL,AKR1C3,ACOT6,GLDC,GCAT,GART,OSBPL6,DPEP1,AASS,RENBP,PC,NIT2,CEMIP,ADH6,QPRT,PSPH,ABAT,GATM,AGPAT6,RGN,CYP4F11,FAH,PPARA,TST,ALDH7A1,PCYOX1,ACAD10,IDH1,DCT,MECP2,CD36,MRS2,AARSD1,BTD,ACSF2,HK1,DDC,CSGALNACT1,IVD,SEPHS2,BRCA1,PCCB,SUCLG2,HSD17B4,GNPDA1,EPHX2,ECHDC1,ENO2,MDH1,IDO2,PAH,CYP4F12,ALDH6A1,ETFA,HYKK,ACSM2A,PLA2G4C,HADH,CYP4F8,CYP1B1,ACSF3,EPHX1,SLC46A1,PLP1,PRODH,NR4A3,MGST2,HAO2,GLYAT
## 27 OTC,XYLB,GSTZ1,CYP24A1,AHCY,PLA2G15,DECR2,DECR1,DHDH,CYP4F2,TGFB1,ALDOC,DAO,CYP27B1,GAPDH,ADTRP,AGXT2,EHHADH,SNX17,ACADS,FAAH,MCEE,CDADC1,APOE,HRSP12,NT5E,ALDH1L2,KHK,LPIN2,BLMH,CYP46A1,PHYH,ASPA,ILVBL,SLC9A1,ACAD11,HIBADH,ALDH8A1,ACAT1,AMDHD1,SLC27A2,IMPA2,PFKL,GALM,ALDH1L1,MUT,DPYS,ACAD8,QDPR,MMAA,HGD,ACAA2,HPD,MCAT,FTCD,ACOX1,HAAO,BDH2,PGM2L1,CRYL1,PCBD1,LDHD,PRODH2,ECI1,AGXT,DCXR,NUDT9,RBKS,ACOX2,GLUL,APOBEC3F,ABCD2,ADPGK,LEP,FUT6,PIPOX,BCKDHB,PCK1,ACOT4,HACL1,ENO3,UPB1,THNSL2,GLUD2,SLC25A21,ACAA1,SHMT2,ENTPD5,DLST,HYAL3,PKLR,MCCC2,GPT2,PFKM,ENOSF1,SYNJ2,ACMSD,ENTPD4,HIBCH,KMO,PFKFB2,ECHS1,INPP5A,OAT,ACADSB,DDO,HOGA1,ACADM,CTH,PGM1,ENTPD1,CPT2,SCP2,ECHDC2,AKR1A1,CEL,MAT1A,ADO,HMGCL,ALDOB,ALDH4A1,AUH,IDNK,C9orf41,TMEM2,ALDH1B1,ECI2,AKR1C3,GLDC,GCAT,NT5M,INPP1,AASS,RENBP,CEMIP,DAK,QPRT,ABAT,CYP4F11,FAH,TST,ALDH7A1,FUT2,PCYOX1,GLYCTK,ACAD10,HK1,DERA,IVD,PCCB,HSD17B4,NUDT16,GNPDA1,ECHDC1,ENO2,TRERF1,IDO2,PAH,CYP4F12,ALDH6A1,ETFA,HYKK,UPP2,HADH,CYP4F8,ACSF3,PRODH,HAO2
## 28 FKBP4,NDUFAF7,FUCA2,RANBP9,XYLT2,CHPF2,LRRC7,OTC,BOD1L1,HDAC7,MRPS35,CAMKK1,DERL2,KIF22,FGF4,NGFR,C12orf5,FGF20,ERLEC1,FAP,PLOD1,CETP,SIRT4,APOH,XYLB,CDC6,KLHL20,GSTA3,TGFBR3,MAPK1,TCN2,SLC25A1,PIK3IP1,DMC1,JOSD1,PNPLA5,PNPLA3,MYH9,PHF5A,PMM1,POLE2,PIGH,GSTZ1,DHRS7,MTHFD1,APEX1,CYP24A1,GSS,EEF1A2,SLC52A3,CHMP4B,AHCY,PGRMC1,PQBP1,GLA,DHODH,PRSS54,SMPD3,PLA2G15,DECR2,CDIPT,MTFMT,AGO2,BRF2,CPQ,DECR1,PPP2CB,PAF1,DHDH,CYP4F2,TGFB1,HAS1,DNASE2,UBE2D4,NOD1,CYP3A5,HYAL4,AIMP2,MOGAT3,CEP41,MRPL32,SETX,SFXN3,DHX33,EPX,PNPO,C1QBP,COL1A1,DUSP3,ALDOC,CD38,APOC3,SART3,DAO,MLEC,CYP27B1,FGF6,OAS3,CNOT2,GAPDH,USP5,COX6A1,GCLC,IYD,ADTRP,FBXO5,FANCE,ACOT13,B3GAT2,DNPH1,PAPD7,HBEGF,LNPEP,AGXT2,ST8SIA4,TRIM23,MLH1,EHHADH,RBP1,RRP9,EIF2AK2,TFPI,TTL,SNX17,EVA1A,PROC,ODC1,MSH6,SARS,SLC35D1,PRDM2,AKR7A2,LEPRE1,ATIC,STBD1,ELL2,GDA,C2orf40,IRF2BPL,FAM98A,PANK3,FYTTD1,AHR,EEPD1,INHBA,ZC3HAV1,SRGN,ACADS,C19orf43,ORMDL2,PDE1B,FAAH,SNRPA,RAB38,PEPD,MCEE,SLC17A1,UNC5CL,EREG,SH2D3A,FOSB,SNRPB2,UROD,UBA2,NR1D1,PTPN12,FGL2,YWHAH,OPN1SW,PIAS1,MBD4,CDADC1,CERS4,ESYT2,UGT2A3,ADAMTS2,NARFL,RAF1,NDUFA2,APOE,ALLC,EPO,PXDN,HRC,ACSS2,NAPSA,NR1H2,G6PC,CHSY1,TRIM21,RRP8,PTCD3,ILKAP,PTPRE,EEFSEC,UTP3,H3F3B,HRSP12,ACY3,DMGDH,BHMT2,PEMT,RNF128,MACROD1,HRASLS2,KRAS,RNF122,ADAMDEC1,IRAK2,NOTCH2,TRIM45,FOLH1,KLB,USP30,DTX1,NT5E,CDK4,TFCP2,MRPL53,BCO1,SLC19A3,EIF4E2,ALDH1L2,TBRG4,HUS1,RSAD1,PSMB7,DERL1,RNF38,HINT2,GMPR,TINAG,GCM1,RIPK1,MRPS18B,TTPA,GGH,SULF1,SORL1,BUD13,MMP27,NDUFAF1,GCHFR,TTLL7,IFT172,KHK,ADCY3,HECW2,WDR12,GUCY2C,TRHDE,LIAS,TRAF5,ENOX1,MSMO1,POMT2,LPIN2,SLC6A4,UTP6,PSMD11,BLMH,TAOK1,AARS,CYP46A1,APH1B,CILP,DAPK2,SPAG9,MCM4,WIPI1,MTFR1,SMARCD3,RCOR1,SCPEP1,LPO,VMP1,LMF1,IL12RB2,CREBBP,GINS1,DENND3,HPN,CCM2L,DHTKD1,PHYH,ASPA,METTL16,PRKCQ,BBOX1,MED15,PLEKHA4,HSD17B14,NOX4,ILVBL,PARP12,APLP2,DCPS,ACVR1,SPCS2,POLD3,SNRNP40,DNAJC8,TYRO3,LRP2,USE1,SLC9A1,GATB,TREH,CBL,CHST10,ALS2,SI,GUCY1B3,RBBP5,HDAC4,DNMT3A,PPAP2A,SLC2A9,MIER2,ARSB,SDHA,ACAD11,MRPL3,GALNT7,MAP3K13,MSH3,FBXW11,SLC1A3,AMBP,ENPEP,CASP6,PAPSS1,ABCB6,CREM,HIBADH,POLB,CALB1,USP4,ALDH8A1,TCIRG1,ADAM28,ACAT1,REXO2,PRPF6,EIF2B2,PLCZ1,AMDHD1,ERBB3,ESYT1,VPS37B,L2HGDH,AK7,SLC27A2,PML,RLBP1,MAP1LC3B,ADAD2,IRF8,COPS3,NOB1,PRPSAP2,RHBDL3,CDH2,IMPA2,SAT2,FN3KRP,IGFBP4,PFKL,PGPEP1,SIK1,PSMB6,PLK4,CTSK,CERS2,EIF2D,REN,GALM,SLC20A1,LIMD1,ALDH1L1,EAF2,CORIN,SETD7,ADAMTS16,FAM105A,BHMT,CRHBP,ADAMTS19,FGF18,MYLK4,MUT,CHST7,ATP6V1B2,ERLIN2,GINS4,LACTB2,DPYS,UHRF2,ASB6,FUOM,CAPN5,ATM,AASDHPPT,FADS2,PIGT,ORAOV1,TM7SF2,ARID5B,PRSS23,IL18,KHDRBS2,PTPRO,ACAD8,QDPR,MMAA,HSPB8,CWF19L2,GPD1L,PTPRR,PLA2R1,GPR116,HGD,JAZF1,CEBPG,THY1,UBASH3B,NEIL2,SH3RF1,ACAA2,CA2,TMEM55A,CASP10,SLC26A2,PXYLP1,RASA2,ADK,DCK,NAAA,TYSND1,PRG3,UBE2L6,AIFM1,BUB1B,EXOG,NMNAT2,IPPK,THTPA,KIT,COQ5,PEX10,HPD,RHBDL2,ACSM3,KPNB1,SCRN2,MCAT,MED8,TRMU,CALM3,TRIM62,FAM207A,FTCD,TMEM199,FLAD1,UBE2Q1,AZGP1,FGFR4,FBXO27,ACOX1,NAGS,ASB16,SLX4,ADCY9,FGF19,TAL1,ZYG11B,AGL,VCAM1,PKDCC,HAAO,SPATA18,HPGDS,TGFA,PTPRN,HDAC11,GLB1L,EIF5A2,FABP1,ALB,MTMR14,SNRK,MRPL33,RPL39L,IL17RD,KIAA0226,METAP1,BDH2,MST1R,PRSS12,HPGD,CMBL,ENPP6,UTP15,PHAX,KIAA1161,PGM2L1,CRYL1,PCF11,LRR1,PRDX3,KIAA1191,LRRK2,LIPC,AMN,PCBD1,TRIM44,RNF169,LEO1,TK2,MMP3,LDHD,ANPEP,GLYATL1,METTL21B,GCN1L1,RNF214,NFATC3,ATP5L,FN3K,SGK494,GPD1,PRODH2,CHAF1A,TSR1,ACER1,ICT1,ATP5H,BIRC5,ECI1,ABCA3,VPS37C,SLC22A11,USP42,PANK1,MGMT,CSDC2,MAP2K1,KBTBD2,AGXT,AXIN2,ONECUT1,ABHD15,SLC23A1,ACHE,IL12A,ACOT12,RNASE2,DCXR,NUDT9,LRP8,CDC25A,INSR,GTPBP2,RBMXL2,HAS3,THOP1,FAM134B,LRRC28,UGT2B4,PRKCB,C20orf196,DRD5,FOS,B4GALT6,CXCL8,DESI2,OGG1,PPIH,RBKS,YEATS2,APLF,FAM103A1,ASL,LCMT2,CHST14,DDIT4,MRC2,ACOX2,GLUL,CHST2,COMMD1,DPY19L1,PLG,VCPIP1,OLR1,EIF1AD,USP48,ACO1,PHYHD1,APOBEC3F,ADAM17,TAOK2,SLC22A13,RASGRP1,INTS6,SART1,DSEL,PSMC5,NUP93,ABCD2,DDX23,CTSF,FBXO31,TRIM59,ACOT1,ATG4D,MUCL1,PDE8A,RSF1,ZNF738,DUS3L,CARKD,UCP2,SSH3,ADPGK,ADRBK1,CD84,KLHL3,PPM1E,PPARGC1B,LEP,CASP2,B3GNT8,HNF4A,SLC35C1,PANK2,FUT6,GRHPR,WHSC1L1,KLHDC3,ANAPC2,PAK2,PRMT9,GBA,ZHX2,SLC28A2,GLTP,TYMS,CHAF1B,CCDC101,B3GNT5,RNF152,SFXN1,MRPS11,RECQL5,PIPOX,CES2,GYS1,DUOX1,OS9,MPI,BCKDHB,BACE1,PRTFDC1,SUMO4,CYP8B1,SUPT6H,STK17A,UGDH,SULT1C2,NQO1,PCK1,CHDH,FARSA,PLA2G16,UGT2B17,VPS37D,ST8SIA3,RNF185,TMEM150B,RNF168,RNF144A,LPA,TTLL11,ASB4,SLC34A1,RRP7A,FGF8,B3GNT3,DPM2,PITPNM2,PORCN,POLE,GLYR1,ACOT4,PDIA5,SLC2A2,HACL1,DDX54,TRIM55,ENO3,UPB1,CYP2B6,NFATC2IP,MBOAT1,MTMR4,ZNF335,NR2F1,SRSF7,PMAIP1,GANC,SRRM1,KDM3B,SMCHD1,NCBP2,NT5DC1,DDHD1,EHD3,CIRH1A,THNSL2,SETD3,CSF1,GLUD2,ACSM5,SLC5A2,FBXO21,TRAIP,DGKA,SEP15,TOP1MT,TRAK1,SLC25A18,PRKCH,SP1,SLC25A21,DRG1,MEX3B,TBK1,TMPRSS11B,MORF4L1,WT1,NPLOC4,FBLN1,ADSSL1,MTA1,EYA2,ACAA1,ADI1,SHMT2,DUSP18,TTF1,RSBN1L,HDAC6,NUDT17,ZMIZ1,TESC,PTPRU,ZNRF1,ENTPD5,DLST,GSTA1,RAD51C,LARP1,ENOX2,LRAT,LIPA,HYAL3,ELAC2,STARD3,CDK10,LRRC8D,RBMX2,RRP1B,KCTD21,NT5C2,NELFB,DFFB,LBR,PKLR,NISCH,ZDHHC1,ACVR2B,SMPD1,NMNAT3,MAOA,MEF2C,ASH2L,MIA3,WNT7B,CECR2,JARID2,CREB3,OAS2,PTGES,IFI6,EYA1,RNF41,PPM1G,PLD1,SP100,RBM5,LCTL,MCCC2,ATR,ESR2,RHBDL1,ATF3,PROZ,NR4A2,RNF133,APOL3,INSIG1,QPCT,PTP4A2,GPT2,PAPLN,PLSCR1,CTSB,NFYA,TOR1A,PFKM,LYAR,ENOSF1,ANXA2,DDX21,DDRGK1,THRAP3,ELOVL2,HNRNPA2B1,EGFLAM,WAC,FMOD,PDE5A,LARGE,KCTD6,SYNJ2,KHDRBS3,STK31,SLC25A46,CYP20A1,ACSL5,ACMSD,STOML2,MAN1A2,SON,HIST1H2BK,ELAVL4,XPNPEP3,ZDHHC9,MAP1LC3C,ACTB,ACSL3,BRPF3,ASB13,NAT9,ELK4,TMCC2,ITIH2,WDR5,ENTPD4,PBLD,PRDM10,PELI1,TGFBR2,PDE3A,WWP2,PIK3CG,NUP214,DNMT1,HAND2,TYW1,HIBCH,SLC39A14,SPN,AGBL5,BAZ1A,CDC16,EIF2B3,DPP4,CLIP3,PAK3,ADARB1,SCYL2,MRPL37,HS3ST3B1,ENPP1,ATP1A2,TOP1,RNF121,MRPL21,PPT2,PTGS1,DIO1,SLC26A1,PCGF3,MVB12B,DRD2,PPEF1,ALPK2,ABCG1,CTNNBL1,NSMCE1,SUCNR1,HORMAD1,INO80,BECN1,PTPLA,AKR7A3,TFB2M,ADSS,EXO1,KMO,FH,GPR137B,AGT,GALNT2,IBA57,PARP1,MARC2,CENPF,HSD11B1,CD55,EZR,PFKFB2,MAPKAPK2,PM20D1,NUAK2,DSTYK,MDM4,PIK3C2B,PPP1R15B,ETNK2,MTRF1L,CYB5R1,KLHL12,RMND1,PTGS2,TPR,LHX4-AS1,RC3H1,SERPINC1,FMO3,HBS1L,MPC2,POU2F1,MGST3,UAP1,VNN1,APOA2,ADAMTS4,NIT1,USF1,IFI16,SPTA1,CD5L,KIAA0907,SYT11,SMPDL3A,PMVK,ECHS1,INPP5A,BNIP3,NPR1,CHTOP,BCCIP,IVL,UROS,THEM5,LHPP,OAT,SLC16A10,ACADSB,PSTK,DDO,HTRA1,PDSS2,ADAMTSL4,TARS2,BAG3,PRDM1,PREP,EIF3A,CACUL1,PNLIPRP3,CHD1L,EPHA7,SCAF11,ZDHHC6,HMGCS2,PHGDH,HSD3B1,DCLRE1B,TTK,FLNA,GNAI3,CYP17A1,HENMT1,ALG14,ABCC2,LRRC8C,PYROXD2,HOGA1,DNASE2B,BAG2,DDX26B,USP33,ACADM,TYW3,EXOSC1,CTH,DIRAS3,GADD45A,PPP1R3D,UBE2U,PGM1,GNAS,XPNPEP2,ANGPTL3,ENTPD1,FGGY,JUN,CYP2C8,PARS2,PLCE1,ARRDC1,SUPT3H,RBP4,CPT2,SCP2,ECHDC2,UBE2A,TMEM189,MRPS2,CYP4B1,MKNK1,RAD54L,NCOA3,CHRDL1,AKR1A1,CEL,MRPS18A,MAT1A,ASS1,CTSA,NEURL2,PPCS,SPTAN1,STK4,GNMT,YWHAB,TRUB2,DNM1,TRMT2B,PLA2G12B,MTF1,SLC25A25,MEAF6,CHST3,MRPS15,MOCS1,EIF4EBP2,RPRD1B,CMTR1,PIM1,COPS7B,FABP3,SRSF3,OGT,ADO,SMPDL3B,TLR4,PHF20,NFS1,OGDHL,PRPF4,UBXN11,DLG3,MDH1B,RASGEF1A,CSGALNACT2,HMGCL,TXN,BMS1,AWAT1,RPL11,WDR46,EPHB2,HSD17B8,AOX1,ALPL,MTMR8,ALDOB,PLPPR1,TEX10,TGFBR1,RNF186,TSR2,HABP4,SIK3,ALDH4A1,DXO,CUL4A,SDHB,F10,AUH,SYK,SECISBP2,AGMAT,APOM,ZCCHC6,PDSS1,MDC1,IDNK,DHX16,MSRB2,STK24,PSAT1,PRUNE2,RFK,C9orf41,KLK6,ABCC4,DFFA,TMEM2,GPC6,UBD,GPC5,KDM2B,UIMC1,ST3GAL5,SLC2A5,CA6,SLC22A12,KLHL21,ALDH1B1,NOL9,MGME1,SNX5,PLCXD3,RRBP1,CUBN,ACOT7,SLC3A2,LECT1,MAOB,PRKCZ,SUCLA2,CYP4V2,BMP2,FTHL17,CHGB,ECHDC3,GFOD1,ACOT9,GATA3,RGCC,RASSF2,NHLRC3,NDNF,GLRX,CDK14,LRRC19,KL,ECI2,BRCA2,USP3,BPHL,RPS6,PIR,PIGA,NQO2,ASB9,COL2A1,ADAMTSL1,AKR1C3,PDE4A,SELO,HUS1B,PAN3,PDX1,PNPLA4,ACOT6,NOP56,PTPRD,GLDC,RDH11,GCAT,GART,TNFRSF19,RAD51,FAHD1,N6AMT2,DRD3,BRPF1,PIP5KL1,GPX3,LRRK1,HSPD1,NT5M,LOXL2,SMYD5,EPHA6,TSN,RNF216,CAPN10,INPP1,GPS1,SRSF2,OSBPL6,NUDT14,ETS1,CERS6,GALNT3,B3GALNT1,GALNT13,GRK5,DPEP1,LGMN,NRF1,SPOP,AASS,SRPK2,RENBP,PSMC3IP,SUCLG1,MRPL19,PC,SUOX,NIT2,METTL7B,MST4,FBXO38,UTP14A,GTF2F1,TRPT1,SLFN11,PNPLA1,SLC28A1,SGMS2,CEMIP,ADH6,DAK,NXF3,DNAJC30,CDK1,AK4,SLC16A9,QPRT,PSPH,SOCS4,LGALS9,A1CF,ADM2,HECW1,YWHAZ,NFATC2,ODAM,HNF4G,AMPD3,TRIM40,ABAT,ZNF143,GATM,UBE2E2,DDX17,FITM2,EAF1,KAT6A,MOCS2,AGPAT6,SLC17A3,NFE2L2,RGN,KDM7A,CHMP1A,EPHB1,GRK4,CTDSP2,WDR4,PPAPDC1A,LARP4,STK32A,MX1,ATP5A1,PARP3,CAPN11,HSDL2,DYRK1A,SPTLC3,ALKBH5,MRPS6,MAP3K1,DLG4,UBXN2B,BACH1,DDX3X,FKBP1A,PCBP3,MAPK4,PPP4R1,MIER1,ASXL2,NHP2L1,EFR3B,HPSE,TRIOBP,PARG,TFIP11,CYP4F11,PNPLA7,CDKN1A,P4HA2,FAH,NCOA1,CAPN14,NOLC1,PPARA,MEX3C,MAST4,GAL3ST1,DGKB,FOXO3,TST,ALAD,C17orf104,AAK1,PSMD14,MCFD2,KDM3A,LYG1,STK16,ALDH7A1,GIGYF2,ATHL1,TMEM150A,ARTN,FUT2,PCYOX1,ZFP36L1,RARG,RNF24,PLCD4,CHEK1,PPP1R12A,GLYCTK,NFATC1,RNF212,ACAD10,DCUN1D4,HERC1,IDH1,HNRNPLL,IRAK4,PSMC2,MTMR11,CHD7,C1orf106,CHFR,DCT,CDC7,CASP14,PPT1,MTFR2,MECP2,TCEB3,TSPAN14,TEX264,FTSJ3,KANSL3,ATXN7L3,TSC22D1,ALPK1,IP6K3,CD36,MRS2,PTPRJ,SLC25A13,ULK3,ERAP2,HNRNPF,AARSD1,CAPNS2,OTOGL,UBE2L3,BTD,GINS3,ACSF2,HK1,CHST15,SNRNP35,BRAP,DDC,FBXO10,ATP5SL,DNAJB14,EZH1,NOP14,ETV1,CA10,TBL1XR1,CDC45,KAT8,PRMT1,TRPV4,ENPP3,EBNA1BP2,USP46,FBP1,PPP1R3E,CHTF8,LAMP2,PRKCA,TBRG1,ARRB1,SUMO3,FIGNL1,NSMAF,ITPKB,NBR1,TOP2A,DHRS12,AOC1,CSGALNACT1,DGKZ,IL5RA,FGF12,EFNA4,ABHD4,PTBP3,CBFB,GOLGA2,TGFBI,DERA,IGFALS,GALNT11,TRA2B,BAP1,PLTP,DUSP7,RRP1,FHIT,MUC4,DBNL,DDI2,GPHN,PPP2R5D,PARP14,CIAO1,IVD,MME,SEPHS2,BRCA1,PCCB,GFM1,SUCLG2,EIF1,RNF183,WWTR1,CDK5,ABHD14B,ABHD6,RNF182,NIM1K,HSD17B4,PDK2,SEPP1,MAML3,MGAT4D,HGFAC,PAQR3,FAM173B,NUDT16,TTC39B,DDX41,USP51,CDK18,GNPDA1,SH3RF2,NEDD4,CNOT6L,ABLIM3,RNASET2,MRPS27,MARCH1,ABL2,MTTP,HS3ST5,PIK3R1,LYN,INTS9,CCNE2,EPHX2,UQCRB,IKBKB,CCDC71L,GSTK1,HSPA8,SPTBN2,CFL1,KDM2A,CASP1,C11orf30,TMPRSS13,INTS4,PAFAH1B2,ECHDC1,DPF2,MYO18A,ENO2,FBXL17,GGA3,MDH1,PDE10A,TRMT112,CUL7,ZCCHC8,TRERF1,CHERP,NR4A1,KIAA0391,MUC12,PCYT2,RBM19,TTLL9,DAPK3,FAR2,IDO2,GALNT6,PDGFRL,MYCBP2,GLB1L2,CTSV,SLC5A8,PHKG1,HIST1H2BG,TIMM50,MMAB,PAH,BRF1,DTX3,CYP4F12,RDH12,ACSS3,RASAL1,ALDH6A1,JKAMP,UBE2J1,LIN52,NAA30,ETFA,GALK2,NUB1,DNASE1L2,HYKK,PHKG2,ZDHHC7,WWOX,OGFOD1,PHLPP2,ACSM2A,SPATA22,TRPV1,VR1,ENSP00000461324,RAB40B,MRPS21,YES1,OTUD7B,MYH3,RPL27,CNTD1,SLC16A2,POLRMT,RDH8,C19orf40,PRKCSH,TRMT1,TMUB2,SAFB,GIPR,APOC4,ACP5,CHMP2A,CTAG1A,LSM4,TAZ,TEAD2,PLA2G4C,NELFCD,UPP2,ADAM21,HADH,DUOX2,POLDIP2,DCP1A,WDR18,TRABD2B,MR1,CYP4F8,HMOX2,NR1H3,SLC25A14,POLR2E,SMOX,CYP1B1,CAMK1D,RPP38,ENC1,HIST1H4A,ACSF3,PHB,DPF3,RHNO1,MYC,RPS6KA5,SH3GLB1,EPHX1,ENSP00000480012,GPIHBP1,METTL8,NCAM1,SLC22A24,MTERF4,DHRS3,SLC46A1,NDFIP2,MCM3,PLP1,PSMC3,PRODH,SOCS2,FMO1,AP5S1,NR4A3,IP6K1,PLEKHA2,MGST2,TPSB2,C9orf72,PRLR,NR2C2,ACD,TMEM106A,GHR,RBM26,OXA1L,HAO2,TSPAN33,PPP1R2,GLYAT,ENSP00000485022,MUC13
## p_value fdr description
## 23 3.04e-28 3.91e-24 Small molecule metabolic process
## 24 6.26e-25 4.02e-21 Organic acid metabolic process
## 25 1.57e-23 6.73e-20 Oxoacid metabolic process
## 26 5.13e-23 1.65e-19 Carboxylic acid metabolic process
## 27 1.17e-19 3.02e-16 Small molecule catabolic process
## 28 1.64e-19 3.51e-16 Metabolic process