##chargement des packages----
library(questionr)
library(tidyverse)
## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
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## ✔ forcats   1.0.0     ✔ stringr   1.5.0
## ✔ ggplot2   3.4.2     ✔ tibble    3.2.1
## ✔ lubridate 1.9.2     ✔ tidyr     1.3.0
## ✔ purrr     1.0.1     
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library(tableone)
library(labelled)
library(gtsummary)
library(GGally)
## Registered S3 method overwritten by 'GGally':
##   method from   
##   +.gg   ggplot2
library(readxl)
library(effects)
## Le chargement a nécessité le package : carData
## lattice theme set by effectsTheme()
## See ?effectsTheme for details.
library(survival)
library(survminer)
## Le chargement a nécessité le package : ggpubr
## 
## Attachement du package : 'survminer'
## 
## L'objet suivant est masqué depuis 'package:survival':
## 
##     myeloma
library(ggplot2)
library(dplyr)
library(knitr)
library(cowplot)
## 
## Attachement du package : 'cowplot'
## 
## L'objet suivant est masqué depuis 'package:ggpubr':
## 
##     get_legend
## 
## L'objet suivant est masqué depuis 'package:lubridate':
## 
##     stamp
library(readxl)

ct_classe <- read_excel("C:/datar/ct_classe.xlsx")

##recodage des variables et bases de données le cas échéant----

var_label(ct_classe$tox_dig) <- "Toxicité digestive"
var_label(ct_classe$tox_muq) <- "Toxicité muqueuse"
var_label(ct_classe$tox_cut) <- "Toxicité cutanée"
var_label(ct_classe$tox_cardio) <- "Toxicité cardiovasculaire"
var_label(ct_classe$tox_oph) <- "Toxicité ophtalmique"
var_label(ct_classe$tox_plum) <- "Toxicité pulmonaire"
var_label(ct_classe$tox_gale) <- "Toxicité générale"
var_label(ct_classe$tox_hemato) <- "Toxicité hématologique"
var_label(ct_classe$tox_musq_os) <- "Toxicité musqulosqueletique"
var_label(ct_classe$tox_rein) <- "Toxicité rénale"
var_label(ct_classe$tox_foie) <- "Toxicité hépatique"
var_label(ct_classe$tox_neuro) <- "Toxicité neuroologique"
var_label(ct_classe$tox_psy) <- "Toxicité psychiatrique"
var_label(ct_classe$tox_bio) <- "Toxicité biologique"


##renommer des variables pour présentation dans les tableaux de résultat

tbl_summary(
  ct_classe, include = c("tox_dig", "tox_muq", "tox_cut",
                            "tox_cardio", "tox_oph", "tox_plum",
                            "tox_gale","tox_hemato" ,"tox_musq_os", "tox_rein",
                         "tox_foie", "tox_neuro", "tox_psy", "tox_bio"),
  statistic = all_continuous() ~ "{median} [{min} - {max}]",
  digits=all_categorical()~ c(0,1)
)
Characteristic N = 651
Toxicité digestive
    acidité gastrique 1 (2.4%)
    constipation 10 (23.8%)
    diarrhée 12 (28.6%)
    diarrhée brûlure anus nausée 1 (2.4%)
    diarrhée douleur gorge 1 (2.4%)
    diarrhée gaz 1 (2.4%)
    diarrhée nausée 1 (2.4%)
    douleur au ventre 2 (4.8%)
    douleur gastrique 2 (4.8%)
    douleurs gastriques 1 (2.4%)
    gastrite diarrhée constipation nausée 1 (2.4%)
    nausée 2 (4.8%)
    nausée constipation 1 (2.4%)
    nausée vomissement 1 (2.4%)
    nausée vomissement diarrhée 1 (2.4%)
    pesanteur gastrique 1 (2.4%)
    pyrosis 1 (2.4%)
    selles impérieuses 1 (2.4%)
    vomissement 1 (2.4%)
    Unknown 23
Toxicité muqueuse
    Aphtes 3 (17.6%)
    Gencives fragilisée 1 (5.9%)
    Gingivite 1 (5.9%)
    Hyposialies nocturnes  1 (5.9%)
    Langue rouge 1 (5.9%)
    Mucite 2 (11.8%)
    Mucites, sécheresse 1 (5.9%)
    Sécheresse 1 (5.9%)
    Sècheresse 1 (5.9%)
    Sécheresse buccale 2 (11.8%)
    Sècheresse buccale 1 (5.9%)
    Sécheresse vaginale 1 (5.9%)
    Stomatite 1 (5.9%)
    Unknown 48
Toxicité cutanée
    Abcès frottement culotte 1 (3.3%)
    Acné juvénile 1 (3.3%)
    Boutons 1 (3.3%)
    Boutons, crevasse 1 (3.3%)
    Boutons, prurit 1 (3.3%)
    Boutons, rash, sécheresse 1 (3.3%)
    Boutons, sécheresse 1 (3.3%)
    Cheveux cassants 1 (3.3%)
    Croûtes cuir chevelu 1 (3.3%)
    Eruption cutanée granuleuse, crevasses 1 (3.3%)
    Eruptions acnéiformes 1 (3.3%)
    Escarre 1 (3.3%)
    Ongles fragiles 1 (3.3%)
    Prurit et couperoses 1 (3.3%)
    Prurit, pellicules 1 (3.3%)
    Prurit, rougeurs 1 (3.3%)
    Rash 3 (10.0%)
    Rash, sécheresse 1 (3.3%)
    Rash, sécheresse, ongle incarné 1 (3.3%)
    Sécheresse 5 (16.7%)
    Sécheresse buccale, nez bouché 1 (3.3%)
    Sécheresse, éruption 1 (3.3%)
    Sécheresse, fissure, brûlure 1 (3.3%)
    Sécheresse, rash 1 (3.3%)
    Unknown 35
Toxicité cardiovasculaire
    Augmentation volume jambes et cuisses 1 (6.7%)
    Hypertension 3 (20.0%)
    Jambes lourdes 2 (13.3%)
    Oedème 1 (6.7%)
    Œdème 4 (26.7%)
    Oedèmes MI et visage, tachycardie 1 (6.7%)
    Palpitations 1 (6.7%)
    Thrombose 1 (6.7%)
    Thrombose veineuse 1 (6.7%)
    Unknown 50
Toxicité ophtalmique
    Carré noir champ de vision 1 (16.7%)
    Difficulté à l'accomodation 1 (16.7%)
    Diploplie, vision floue, perte des couleurs 1 (16.7%)
    Halo oculaire 1 (16.7%)
    Sécheresse oculaire 2 (33.3%)
    Unknown 59
Toxicité pulmonaire
    Dyspnée 3 (20.0%)
    Laryngite 1 (6.7%)
    Mucus 1 (6.7%)
    Mucus jaunes 1 (6.7%)
    Oppression thoracique 1 (6.7%)
    Toux 5 (33.3%)
    Toux, dyspnée 1 (6.7%)
    Toux, mucus épais 1 (6.7%)
    Toux, oppression thoracique 1 (6.7%)
    Unknown 50
Toxicité générale
    Asthénie 5 (20.0%)
    Asthénie, perte d'appétit 4 (16.0%)
    Asthénie, perte de poids, agueusie 1 (4.0%)
    Asthénie, perte de poids, dysgueusie 1 (4.0%)
    Dysgueusie 1 (4.0%)
    Fatigue, perte d'appétit 1 (4.0%)
    Kyste sébacé dorsal, maux de gorge 1 (4.0%)
    Perte d'appétit 5 (20.0%)
    Perte de poids 5 (20.0%)
    Perte de poids, anosmie, dysgueusie 1 (4.0%)
    Unknown 40
Toxicité hématologique
    Anémie 1 (16.7%)
    Epistaxis 3 (50.0%)
    Hématome 1 (16.7%)
    Thrombopénie 1 (16.7%)
    Unknown 59
Toxicité musqulosqueletique
    Crampes 2 (9.1%)
    Cruralgie, épanchement de la cheville 1 (4.5%)
    Douleur 1 (4.5%)
    Douleur au genou 1 (4.5%)
    Douleur aux mollets 1 (4.5%)
    Douleur dorsale 1 (4.5%)
    Douleur dos, cervicales 1 (4.5%)
    Douleurs 5 (22.7%)
    Douleurs articulaires 1 (4.5%)
    Faiblesse à la jambe 1 (4.5%)
    Faiblesse musculaire 1 (4.5%)
    Fatigue musculaire, douleur au pied 1 (4.5%)
    Fracture du fémur 1 (4.5%)
    Fracture du poignet 1 (4.5%)
    Fracture, douleur 1 (4.5%)
    Mysthénie 1 (4.5%)
    tendinite 1 (4.5%)
    Unknown 43
Toxicité rénale
    Infections urinaires 1 (25.0%)
    insuffisance renale aigue fonctionnelle 1 (25.0%)
    Suspiscion d'infection urinaire 1 (25.0%)
    Urines foncées 1 (25.0%)
    Unknown 61
Toxicité hépatique
    Ascite 1 (33.3%)
    Douleur au foie 2 (66.7%)
    Unknown 62
Toxicité neuroologique
    Céphalée, vertige 1 (9.1%)
    céphalées 1 (9.1%)
    Confusion 1 (9.1%)
    Paresthésie 2 (18.2%)
    Syndrome de la queue de cheval, tremblements 1 (9.1%)
    Tremblement, paresthésie 1 (9.1%)
    Trouble du sommeil 2 (18.2%)
    Vertige 1 (9.1%)
    Vertige, céphalée 1 (9.1%)
    Unknown 54
Toxicité psychiatrique
    Anxiété 2 (33.3%)
    Dépression 1 (16.7%)
    Trouble de l'humeur 2 (33.3%)
    Trouble du sommeil 1 (16.7%)
    Unknown 59
Toxicité biologique
    Augmentation cholestérol, glycémie 0,6 1 (12.5%)
    Augmentation CPK 2 (25.0%)
    Augmentation des CPK 2 (25.0%)
    Augmentation PAL et CPK 1 (12.5%)
    hypokaliémie 1 (12.5%)
    Hypokaliémie 1 (12.5%)
    Unknown 57
1 n (%) 
##
tbl_summary(
  ct_classe, include = c("tox_dig", "tox_cut", "tox_muq",
                         "tox_cardio", "tox_oph", "tox_plum", 
                         "tox_gale","tox_hemato" ,"tox_musq_os", "tox_rein",
                         "tox_foie", "tox_neuro", "tox_psy", "tox_bio"),
  statistic = all_continuous() ~ "{median} [{min} - {max}]",
  by="medt",
  digits=all_categorical()~ c(0,1)
)
Characteristic Afatinib, N = 51 Alectinib, N = 51 Brigatinib, N = 61 Cabozantinib, N = 21 Crizotinib, N = 21 Dabrafénib/Trametinib, N = 11 Evérolimus, N = 41 Lenvatinib, N = 11 Lorlatinib, N = 51 Mobocertinib, N = 21 Osimertinib, N = 261 Osimertinib/Crizotinib, N = 11 Sotorasib, N = 51
Toxicité digestive
    acidité gastrique 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (25.0%)
    constipation 0 (0.0%) 3 (100.0%) 0 (NA%) 1 (100.0%) 2 (100.0%) 1 (100.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (0.0%) 2 (11.1%) 0 (0.0%) 0 (0.0%)
    diarrhée 3 (60.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (0.0%) 7 (38.9%) 0 (0.0%) 1 (25.0%)
    diarrhée brûlure anus nausée 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
    diarrhée douleur gorge 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (5.6%) 0 (0.0%) 0 (0.0%)
    diarrhée gaz 1 (20.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
    diarrhée nausée 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
    douleur au ventre 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 2 (11.1%) 0 (0.0%) 0 (0.0%)
    douleur gastrique 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 2 (100.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
    douleurs gastriques 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (5.6%) 0 (0.0%) 0 (0.0%)
    gastrite diarrhée constipation nausée 1 (20.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
    nausée 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (5.6%) 0 (0.0%) 1 (25.0%)
    nausée constipation 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (25.0%)
    nausée vomissement 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (5.6%) 0 (0.0%) 0 (0.0%)
    nausée vomissement diarrhée 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (5.6%) 0 (0.0%) 0 (0.0%)
    pesanteur gastrique 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (5.6%) 0 (0.0%) 0 (0.0%)
    pyrosis 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (5.6%) 0 (0.0%) 0 (0.0%)
    selles impérieuses 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
    vomissement 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%) 0 (0.0%)
    Unknown 0 2 6 1 0 0 2 0 3 0 8 0 1
Toxicité cutanée
    Abcès frottement culotte 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Acné juvénile 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Boutons 0 (0.0%) 1 (50.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Boutons, crevasse 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Boutons, prurit 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Boutons, rash, sécheresse 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Boutons, sécheresse 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Cheveux cassants 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (100.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Croûtes cuir chevelu 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Eruption cutanée granuleuse, crevasses 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Eruptions acnéiformes 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Escarre 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Ongles fragiles 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Prurit et couperoses 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Prurit, pellicules 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Prurit, rougeurs 0 (0.0%) 1 (50.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Rash 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 1 (50.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Rash, sécheresse 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Rash, sécheresse, ongle incarné 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Sécheresse 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (100.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 3 (18.8%) 0 (NA%) 0 (0.0%)
    Sécheresse buccale, nez bouché 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Sécheresse, éruption 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 1 (50.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Sécheresse, fissure, brûlure 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (6.2%) 0 (NA%) 0 (0.0%)
    Sécheresse, rash 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Unknown 1 3 6 2 2 0 3 1 4 0 10 1 2
Toxicité muqueuse
    Aphtes 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 3 (37.5%) 0 (NA%) 0 (NA%)
    Gencives fragilisée 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (12.5%) 0 (NA%) 0 (NA%)
    Gingivite 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Hyposialies nocturnes  0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (12.5%) 0 (NA%) 0 (NA%)
    Langue rouge 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (100.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Mucite 2 (50.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Mucites, sécheresse 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Sécheresse 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (12.5%) 0 (NA%) 0 (NA%)
    Sècheresse 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (12.5%) 0 (NA%) 0 (NA%)
    Sécheresse buccale 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Sècheresse buccale 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 1 (12.5%) 0 (NA%) 0 (NA%)
    Sécheresse vaginale 0 (0.0%) 1 (100.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Stomatite 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Unknown 1 4 6 1 2 0 4 1 4 1 18 1 5
Toxicité cardiovasculaire
    Augmentation volume jambes et cuisses 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Hypertension 0 (NA%) 0 (0.0%) 1 (100.0%) 2 (100.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Jambes lourdes 0 (NA%) 1 (33.3%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Oedème 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Œdème 0 (NA%) 2 (66.7%) 0 (0.0%) 0 (0.0%) 1 (100.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Oedèmes MI et visage, tachycardie 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (50.0%) 0 (NA%) 0 (NA%)
    Palpitations 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Thrombose 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (50.0%) 0 (NA%) 0 (NA%)
    Thrombose veineuse 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Unknown 5 2 5 0 1 0 2 0 3 2 24 1 5
Toxicité ophtalmique
    Carré noir champ de vision 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (50.0%) 0 (NA%) 0 (NA%)
    Difficulté à l'accomodation 0 (0.0%) 1 (100.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Diploplie, vision floue, perte des couleurs 1 (50.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Halo oculaire 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (50.0%) 0 (NA%) 0 (NA%)
    Sécheresse oculaire 1 (50.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Unknown 3 4 6 2 2 1 4 1 5 1 24 1 5
Toxicité pulmonaire
    Dyspnée 0 (NA%) 2 (66.7%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (20.0%) 0 (NA%) 0 (0.0%)
    Laryngite 0 (NA%) 1 (33.3%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Mucus 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Mucus jaunes 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (20.0%) 0 (NA%) 0 (0.0%)
    Oppression thoracique 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (20.0%) 0 (NA%) 0 (0.0%)
    Toux 0 (NA%) 0 (0.0%) 2 (66.7%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (20.0%) 0 (NA%) 1 (50.0%)
    Toux, dyspnée 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (20.0%) 0 (NA%) 0 (0.0%)
    Toux, mucus épais 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (50.0%)
    Toux, oppression thoracique 0 (NA%) 0 (0.0%) 1 (33.3%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Unknown 5 2 3 2 2 0 4 1 4 2 21 1 3
Toxicité générale
    Asthénie 0 (0.0%) 1 (100.0%) 2 (100.0%) 1 (100.0%) 0 (0.0%) 0 (NA%) 1 (33.3%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Asthénie, perte d'appétit 1 (33.3%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 2 (100.0%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Asthénie, perte de poids, agueusie 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (11.1%) 0 (NA%) 0 (0.0%)
    Asthénie, perte de poids, dysgueusie 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Dysgueusie 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (100.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Fatigue, perte d'appétit 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (11.1%) 0 (NA%) 0 (0.0%)
    Kyste sébacé dorsal, maux de gorge 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (11.1%) 0 (NA%) 0 (0.0%)
    Perte d'appétit 1 (33.3%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (33.3%) 0 (NA%) 0 (NA%) 0 (0.0%) 2 (22.2%) 0 (NA%) 1 (33.3%)
    Perte de poids 1 (33.3%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (33.3%) 0 (NA%) 0 (NA%) 0 (0.0%) 3 (33.3%) 0 (NA%) 0 (0.0%)
    Perte de poids, anosmie, dysgueusie 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (11.1%) 0 (NA%) 0 (0.0%)
    Unknown 2 4 4 1 1 1 1 1 5 0 17 1 2
Toxicité hématologique
    Anémie 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (100.0%)
    Epistaxis 1 (100.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 2 (50.0%) 0 (NA%) 0 (0.0%)
    Hématome 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (25.0%) 0 (NA%) 0 (0.0%)
    Thrombopénie 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (25.0%) 0 (NA%) 0 (0.0%)
    Unknown 4 5 6 2 2 1 4 1 5 2 22 1 4
Toxicité musqulosqueletique
    Crampes 0 (0.0%) 0 (0.0%) 1 (50.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (14.3%) 0 (NA%) 0 (0.0%)
    Cruralgie, épanchement de la cheville 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (14.3%) 0 (NA%) 0 (0.0%)
    Douleur 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Douleur au genou 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (33.3%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Douleur aux mollets 0 (0.0%) 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Douleur dorsale 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (33.3%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Douleur dos, cervicales 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (14.3%) 0 (NA%) 0 (0.0%)
    Douleurs 0 (0.0%) 1 (25.0%) 1 (50.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 2 (28.6%) 0 (NA%) 1 (33.3%)
    Douleurs articulaires 1 (50.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Faiblesse à la jambe 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (33.3%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Faiblesse musculaire 0 (0.0%) 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Fatigue musculaire, douleur au pied 0 (0.0%) 1 (25.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Fracture du fémur 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (14.3%) 0 (NA%) 0 (0.0%)
    Fracture du poignet 1 (50.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Fracture, douleur 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Mysthénie 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    tendinite 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 1 (14.3%) 0 (NA%) 0 (0.0%)
    Unknown 3 1 4 2 2 1 4 0 2 2 19 1 2
Toxicité rénale
    Infections urinaires 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (100.0%)
    insuffisance renale aigue fonctionnelle 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (0.0%)
    Suspiscion d'infection urinaire 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Urines foncées 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 1 (100.0%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Unknown 5 5 6 2 2 1 3 0 5 2 25 1 4
Toxicité hépatique
    Ascite 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%)
    Douleur au foie 0 (NA%) 0 (NA%) 2 (100.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%)
    Unknown 5 5 4 2 2 1 4 1 4 2 26 1 5
Toxicité neuroologique
    Céphalée, vertige 0 (0.0%) 0 (NA%) 1 (33.3%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    céphalées 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (33.3%) 0 (NA%) 0 (0.0%)
    Confusion 1 (50.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Paresthésie 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (33.3%) 0 (NA%) 1 (33.3%)
    Syndrome de la queue de cheval, tremblements 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Tremblement, paresthésie 1 (50.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Trouble du sommeil 0 (0.0%) 0 (NA%) 1 (33.3%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (33.3%) 0 (NA%) 0 (0.0%)
    Vertige 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (33.3%)
    Vertige, céphalée 0 (0.0%) 0 (NA%) 1 (33.3%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%)
    Unknown 3 5 3 2 2 1 4 1 5 2 23 1 2
Toxicité psychiatrique
    Anxiété 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (0.0%) 1 (100.0%) 0 (NA%) 0 (NA%) 0 (0.0%)
    Dépression 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%)
    Trouble de l'humeur 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 2 (100.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (0.0%)
    Trouble du sommeil 0 (NA%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 1 (100.0%)
    Unknown 5 5 6 2 1 1 3 1 3 1 26 1 4
Toxicité biologique
    Augmentation cholestérol, glycémie 0,6 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Augmentation CPK 0 (NA%) 2 (66.7%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Augmentation des CPK 0 (NA%) 0 (0.0%) 2 (100.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Augmentation PAL et CPK 0 (NA%) 1 (33.3%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    hypokaliémie 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (NA%)
    Hypokaliémie 0 (NA%) 0 (0.0%) 0 (0.0%) 0 (NA%) 0 (NA%) 0 (NA%) 1 (100.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (0.0%) 0 (NA%) 0 (NA%)
    Unknown 5 2 4 2 2 1 3 1 4 2 25 1 5
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