Tables
## # A tibble: 5 × 5
## aki_stage_4 death_discharge event_rate_30 event_rate_60 event_rate_90
## <dbl> <dbl> <dbl> <dbl> <dbl>
## 1 1 0.182 0.232 0.303 0.343
## 2 2 0.191 0.261 0.351 0.405
## 3 3 0.341 0.434 0.478 0.527
## 4 4 0.573 0.530 0.624 0.658
## 5 NA 0.5 1 1 1
## # A tibble: 3 × 5
## icu_admission death_discharge event_rate_30 event_rate_60 event_rate_90
## <dbl> <dbl> <dbl> <dbl> <dbl>
## 1 0 0.0613 0.147 0.227 0.270
## 2 1 0.488 0.502 0.575 0.619
## 3 NA 0 0 0 0
## # A tibble: 4 × 5
## AKI_responders death_discharge event_rate_30 event_rate_60 event_rate_90
## <chr> <dbl> <dbl> <dbl> <dbl>
## 1 complete response 0.0600 0.0728 0.139 0.212
## 2 no response 0.551 0.577 0.654 0.684
## 3 partial response 0.192 0.273 0.354 0.404
## 4 <NA> 0.5 1 1 1
## # A tibble: 2 × 5
## respiratory_failure_cat death_discharge event_rate_30 event_rate_60
## <chr> <dbl> <dbl> <dbl>
## 1 Ordinal 1-2 0.625 0.599 0.673
## 2 Ordinal 3-5 0.159 0.243 0.317
## # ℹ 1 more variable: event_rate_90 <dbl>
## # A tibble: 2 × 5
## liver_transplant_listed death_discharge event_rate_30 event_rate_60
## <dbl> <dbl> <dbl> <dbl>
## 1 0 0.400 0.441 0.518
## 2 1 0.220 0.195 0.256
## # ℹ 1 more variable: event_rate_90 <dbl>
KM Plot
aki_stage_4
age_admission+sex+White+hispanic_race+MELD_Na_baseline+hrs_vasoconstrictor+icu_admission+liver_transplant_listed
## 17 cases omitted due to missing values
| Characteristic |
N |
HR |
95% CI |
p-value |
| aki_stage_4 |
611 |
|
|
|
| 1 |
|
— |
— |
|
| 2 |
|
1.00 |
0.62, 1.59 |
0.990 |
| 3 |
|
1.23 |
0.82, 1.86 |
0.320 |
| 4 |
|
1.59 |
1.06, 2.39 |
0.025 |
| age_admission |
611 |
1.01 |
1.00, 1.02 |
0.100 |
| sex |
611 |
|
|
|
| Female |
|
— |
— |
|
| Male |
|
1.03 |
0.81, 1.29 |
0.840 |
| White |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.87 |
0.66, 1.14 |
0.300 |
| hispanic_race |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.60 |
0.37, 0.98 |
0.041 |
| MELD_Na_baseline |
611 |
1.04 |
1.02, 1.05 |
<0.001 |
| hrs_vasoconstrictor |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
1.01 |
0.79, 1.29 |
0.950 |
| icu_admission |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
2.58 |
1.85, 3.58 |
<0.001 |
| liver_transplant_listed |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.26 |
0.16, 0.42 |
<0.001 |
icu_admission
age_admission+sex+White+hispanic_race+MELD_Na_baseline+hrs_vasoconstrictor+liver_transplant_listed
## 15 cases omitted due to missing values
| Characteristic |
N |
HR |
95% CI |
p-value |
| icu_admission |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
2.94 |
2.14, 4.02 |
<0.001 |
| age_admission |
613 |
1.01 |
1.00, 1.02 |
0.140 |
| sex |
613 |
|
|
|
| Female |
|
— |
— |
|
| Male |
|
1.01 |
0.80, 1.27 |
0.950 |
| White |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.84 |
0.64, 1.10 |
0.200 |
| hispanic_race |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.60 |
0.36, 0.99 |
0.046 |
| MELD_Na_baseline |
613 |
1.04 |
1.03, 1.06 |
<0.001 |
| hrs_vasoconstrictor |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
1.06 |
0.83, 1.35 |
0.650 |
| liver_transplant_listed |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.28 |
0.17, 0.44 |
<0.001 |
respiratory_failure_cat
adjusted
age_admission+sex+White+hispanic_race+MELD_Na_baseline+hrs_vasoconstrictor+icu_admission
+ liver_transplant_listed
## 15 cases omitted due to missing values
| Characteristic |
N |
HR |
95% CI |
p-value |
| respiratory_failure_cat |
613 |
|
|
|
| Ordinal 1-2 |
|
— |
— |
|
| Ordinal 3-5 |
|
0.46 |
0.35, 0.59 |
<0.001 |
| age_admission |
613 |
1.01 |
1.00, 1.02 |
0.066 |
| sex |
613 |
|
|
|
| Female |
|
— |
— |
|
| Male |
|
0.99 |
0.79, 1.25 |
0.950 |
| White |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.89 |
0.68, 1.17 |
0.420 |
| hispanic_race |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.56 |
0.34, 0.93 |
0.025 |
| MELD_Na_baseline |
613 |
1.05 |
1.03, 1.06 |
<0.001 |
| hrs_vasoconstrictor |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
1.08 |
0.85, 1.37 |
0.520 |
| icu_admission |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
1.84 |
1.28, 2.65 |
0.001 |
| liver_transplant_listed |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.28 |
0.17, 0.45 |
<0.001 |
AKI_responders
adjusted
age_admission+sex+White+hispanic_race+MELD_Na_baseline+hrs_vasoconstrictor+icu_admission
+ liver_transplant_listed
## 17 cases omitted due to missing values
| Characteristic |
N |
HR |
95% CI |
p-value |
| AKI_responders |
611 |
|
|
|
| complete response |
|
— |
— |
|
| no response |
|
5.04 |
3.51, 7.23 |
<0.001 |
| partial response |
|
2.84 |
1.83, 4.41 |
<0.001 |
| age_admission |
611 |
1.01 |
1.00, 1.02 |
0.190 |
| sex |
611 |
|
|
|
| Female |
|
— |
— |
|
| Male |
|
1.05 |
0.83, 1.34 |
0.660 |
| White |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.93 |
0.70, 1.23 |
0.600 |
| hispanic_race |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.62 |
0.38, 1.02 |
0.060 |
| MELD_Na_baseline |
611 |
1.04 |
1.02, 1.06 |
<0.001 |
| hrs_vasoconstrictor |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.95 |
0.73, 1.22 |
0.670 |
| icu_admission |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
2.41 |
1.73, 3.37 |
<0.001 |
| liver_transplant_listed |
611 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.22 |
0.14, 0.36 |
<0.001 |
liver_transplant_listed
adjusted
age_admission+sex+White+hispanic_race+MELD_Na_baseline+hrs_vasoconstrictor+icu_admission
## 15 cases omitted due to missing values
| Characteristic |
N |
HR |
95% CI |
p-value |
| liver_transplant_listed |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.28 |
0.17, 0.44 |
<0.001 |
| age_admission |
613 |
1.01 |
1.00, 1.02 |
0.140 |
| sex |
613 |
|
|
|
| Female |
|
— |
— |
|
| Male |
|
1.01 |
0.80, 1.27 |
0.950 |
| White |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.84 |
0.64, 1.10 |
0.200 |
| hispanic_race |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
0.60 |
0.36, 0.99 |
0.046 |
| MELD_Na_baseline |
613 |
1.04 |
1.03, 1.06 |
<0.001 |
| hrs_vasoconstrictor |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
1.06 |
0.83, 1.35 |
0.650 |
| icu_admission |
613 |
|
|
|
| 0 |
|
— |
— |
|
| 1 |
|
2.94 |
2.14, 4.02 |
<0.001 |