Competing risk Univariate model 1
Characteristic |
N |
HR |
95% CI |
p-value |
age_admission |
1,876 |
1.00 |
1.00, 1.01 |
0.700 |
meld_3 |
1,876 |
1.04 |
1.03, 1.05 |
<0.001 |
etiology_cirrhosis |
1,876 |
|
|
|
    Alcohol |
|
— |
— |
|
    HCV |
|
1.14 |
0.89, 1.46 |
0.300 |
    Multifactorial |
|
0.92 |
0.69, 1.22 |
0.560 |
    NASH |
|
0.82 |
0.66, 1.00 |
0.056 |
    Other |
|
1.13 |
0.92, 1.39 |
0.230 |
hcc_admission |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.76 |
1.44, 2.15 |
<0.001 |
diabetes |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.70 |
0.60, 0.82 |
<0.001 |
cad |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.91 |
0.75, 1.10 |
0.320 |
ckd |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.71 |
0.60, 0.85 |
<0.001 |
htn |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.75 |
0.64, 0.87 |
<0.001 |
site |
1,876 |
|
|
|
    baylor |
|
— |
— |
|
    indiana |
|
1.89 |
1.39, 2.57 |
<0.001 |
    jacksonville |
|
0.64 |
0.37, 1.10 |
0.100 |
    kentukey |
|
2.51 |
1.76, 3.57 |
<0.001 |
    MCW |
|
1.48 |
1.04, 2.10 |
0.028 |
    mgh |
|
1.00 |
0.74, 1.35 |
0.990 |
    michigan |
|
1.01 |
0.69, 1.48 |
0.950 |
    oschner |
|
2.14 |
1.49, 3.09 |
<0.001 |
    rochester |
|
0.94 |
0.67, 1.31 |
0.710 |
    usc |
|
0.87 |
0.50, 1.49 |
0.610 |
    yale |
|
1.21 |
0.87, 1.68 |
0.270 |
Competing risk Multivariate model 1
Characteristic |
N |
HR |
95% CI |
p-value |
age_admission |
1,876 |
1.02 |
1.01, 1.02 |
<0.001 |
meld_3 |
1,876 |
1.04 |
1.03, 1.05 |
<0.001 |
etiology_cirrhosis |
1,876 |
|
|
|
    Alcohol |
|
— |
— |
|
    HCV |
|
1.33 |
1.02, 1.73 |
0.038 |
    Multifactorial |
|
0.80 |
0.58, 1.11 |
0.180 |
    NASH |
|
1.01 |
0.80, 1.29 |
0.910 |
    Other |
|
1.40 |
1.11, 1.76 |
0.004 |
hcc_admission |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.73 |
1.39, 2.16 |
<0.001 |
diabetes |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.82 |
0.69, 0.98 |
0.026 |
cad |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.13 |
0.92, 1.39 |
0.250 |
ckd |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.71 |
0.58, 0.86 |
<0.001 |
htn |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.89 |
0.75, 1.06 |
0.180 |
site |
1,876 |
|
|
|
    baylor |
|
— |
— |
|
    indiana |
|
1.48 |
1.08, 2.03 |
0.014 |
    jacksonville |
|
0.50 |
0.29, 0.87 |
0.015 |
    kentukey |
|
2.55 |
1.78, 3.65 |
<0.001 |
    MCW |
|
1.47 |
1.03, 2.08 |
0.032 |
    mgh |
|
0.97 |
0.72, 1.31 |
0.860 |
    michigan |
|
1.08 |
0.74, 1.58 |
0.690 |
    oschner |
|
1.47 |
0.99, 2.18 |
0.059 |
    rochester |
|
0.92 |
0.66, 1.29 |
0.640 |
    usc |
|
0.60 |
0.34, 1.05 |
0.074 |
    yale |
|
1.11 |
0.81, 1.54 |
0.520 |
Competing risk Univariate model 2
Characteristic |
N |
HR |
95% CI |
p-value |
age_admission |
1,876 |
1.00 |
1.00, 1.01 |
0.700 |
meld_3 |
1,876 |
1.04 |
1.03, 1.05 |
<0.001 |
etiology_cirrhosis |
1,876 |
|
|
|
    Alcohol |
|
— |
— |
|
    HCV |
|
1.14 |
0.89, 1.46 |
0.300 |
    Multifactorial |
|
0.92 |
0.69, 1.22 |
0.560 |
    NASH |
|
0.82 |
0.66, 1.00 |
0.056 |
    Other |
|
1.13 |
0.92, 1.39 |
0.230 |
hcc_admission |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.76 |
1.44, 2.15 |
<0.001 |
site |
1,876 |
|
|
|
    baylor |
|
— |
— |
|
    indiana |
|
1.89 |
1.39, 2.57 |
<0.001 |
    jacksonville |
|
0.64 |
0.37, 1.10 |
0.100 |
    kentukey |
|
2.51 |
1.76, 3.57 |
<0.001 |
    MCW |
|
1.48 |
1.04, 2.10 |
0.028 |
    mgh |
|
1.00 |
0.74, 1.35 |
0.990 |
    michigan |
|
1.01 |
0.69, 1.48 |
0.950 |
    oschner |
|
2.14 |
1.49, 3.09 |
<0.001 |
    rochester |
|
0.94 |
0.67, 1.31 |
0.710 |
    usc |
|
0.87 |
0.50, 1.49 |
0.610 |
    yale |
|
1.21 |
0.87, 1.68 |
0.270 |
Competing risk Multivariate model 2
Characteristic |
N |
HR |
95% CI |
p-value |
age_admission |
1,876 |
1.01 |
1.01, 1.02 |
<0.001 |
meld_3 |
1,876 |
1.04 |
1.03, 1.05 |
<0.001 |
etiology_cirrhosis |
1,876 |
|
|
|
    Alcohol |
|
— |
— |
|
    HCV |
|
1.24 |
0.95, 1.61 |
0.110 |
    Multifactorial |
|
0.76 |
0.55, 1.07 |
0.120 |
    NASH |
|
0.88 |
0.70, 1.12 |
0.300 |
    Other |
|
1.30 |
1.04, 1.64 |
0.021 |
hcc_admission |
1,876 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.78 |
1.43, 2.22 |
<0.001 |
site |
1,876 |
|
|
|
    baylor |
|
— |
— |
|
    indiana |
|
1.68 |
1.23, 2.29 |
0.001 |
    jacksonville |
|
0.53 |
0.30, 0.92 |
0.023 |
    kentukey |
|
2.46 |
1.72, 3.52 |
<0.001 |
    MCW |
|
1.61 |
1.13, 2.29 |
0.008 |
    mgh |
|
0.97 |
0.72, 1.31 |
0.850 |
    michigan |
|
1.15 |
0.79, 1.66 |
0.460 |
    oschner |
|
1.55 |
1.03, 2.33 |
0.034 |
    rochester |
|
0.97 |
0.70, 1.36 |
0.870 |
    usc |
|
0.68 |
0.39, 1.20 |
0.180 |
    yale |
|
1.16 |
0.84, 1.60 |
0.370 |
KM Plot HRS cohort

HRS cohort
Competing risk Univariate model 1 HRS cohort
Characteristic |
N |
HR |
95% CI |
p-value |
age_admission |
227 |
1.01 |
1.00, 1.03 |
0.140 |
meld_3 |
227 |
1.01 |
0.99, 1.04 |
0.250 |
etiology_cirrhosis |
227 |
|
|
|
    Alcohol |
|
— |
— |
|
    HCV |
|
1.78 |
1.01, 3.14 |
0.045 |
    Multifactorial |
|
0.91 |
0.36, 2.31 |
0.850 |
    NASH |
|
0.62 |
0.39, 0.98 |
0.043 |
    Other |
|
1.15 |
0.63, 2.08 |
0.650 |
hcc_admission |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
2.05 |
1.26, 3.35 |
0.004 |
diabetes |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.08 |
0.75, 1.58 |
0.670 |
cad |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.85 |
0.46, 1.55 |
0.590 |
ckd |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.69 |
0.47, 1.02 |
0.060 |
htn |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.28 |
0.88, 1.86 |
0.190 |
site |
227 |
|
|
|
    baylor |
|
— |
— |
|
    indiana |
|
0.92 |
0.26, 3.25 |
0.900 |
    jacksonville |
|
0.73 |
0.20, 2.76 |
0.650 |
    kentukey |
|
1.75 |
0.69, 4.41 |
0.240 |
    MCW |
|
1.45 |
0.52, 4.03 |
0.480 |
    mgh |
|
1.47 |
0.61, 3.58 |
0.390 |
    michigan |
|
4.68 |
1.84, 11.9 |
0.001 |
    oschner |
|
2.45 |
0.93, 6.45 |
0.069 |
    rochester |
|
0.84 |
0.30, 2.39 |
0.750 |
    usc |
|
0.49 |
0.12, 2.11 |
0.340 |
    yale |
|
2.68 |
1.03, 7.00 |
0.044 |
Competing risk Multivariate model 1 HRS cohort
Characteristic |
N |
HR |
95% CI |
p-value |
age_admission |
227 |
1.02 |
1.00, 1.05 |
0.051 |
meld_3 |
227 |
1.03 |
1.00, 1.05 |
0.036 |
etiology_cirrhosis |
227 |
|
|
|
    Alcohol |
|
— |
— |
|
    HCV |
|
1.16 |
0.62, 2.18 |
0.640 |
    Multifactorial |
|
0.72 |
0.29, 1.80 |
0.480 |
    NASH |
|
0.69 |
0.40, 1.20 |
0.190 |
    Other |
|
1.43 |
0.74, 2.76 |
0.280 |
hcc_admission |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.45 |
0.84, 2.52 |
0.190 |
diabetes |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.34 |
0.87, 2.04 |
0.180 |
cad |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.77 |
0.38, 1.55 |
0.470 |
ckd |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
0.65 |
0.40, 1.07 |
0.088 |
htn |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.22 |
0.80, 1.87 |
0.360 |
site |
227 |
|
|
|
    baylor |
|
— |
— |
|
    indiana |
|
0.74 |
0.19, 2.83 |
0.660 |
    jacksonville |
|
0.47 |
0.11, 2.04 |
0.320 |
    kentukey |
|
1.64 |
0.61, 4.40 |
0.320 |
    MCW |
|
1.22 |
0.41, 3.63 |
0.720 |
    mgh |
|
1.04 |
0.40, 2.67 |
0.940 |
    michigan |
|
3.66 |
1.26, 10.6 |
0.017 |
    oschner |
|
2.18 |
0.78, 6.13 |
0.140 |
    rochester |
|
0.89 |
0.29, 2.76 |
0.840 |
    usc |
|
0.52 |
0.12, 2.32 |
0.390 |
    yale |
|
2.38 |
0.91, 6.24 |
0.077 |
Competing risk Univariate model 2 HRS cohort
Characteristic |
N |
HR |
95% CI |
p-value |
age_admission |
227 |
1.01 |
1.00, 1.03 |
0.140 |
meld_3 |
227 |
1.01 |
0.99, 1.04 |
0.250 |
etiology_cirrhosis |
227 |
|
|
|
    Alcohol |
|
— |
— |
|
    HCV |
|
1.78 |
1.01, 3.14 |
0.045 |
    Multifactorial |
|
0.91 |
0.36, 2.31 |
0.850 |
    NASH |
|
0.62 |
0.39, 0.98 |
0.043 |
    Other |
|
1.15 |
0.63, 2.08 |
0.650 |
hcc_admission |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
2.05 |
1.26, 3.35 |
0.004 |
site |
227 |
|
|
|
    baylor |
|
— |
— |
|
    indiana |
|
0.92 |
0.26, 3.25 |
0.900 |
    jacksonville |
|
0.73 |
0.20, 2.76 |
0.650 |
    kentukey |
|
1.75 |
0.69, 4.41 |
0.240 |
    MCW |
|
1.45 |
0.52, 4.03 |
0.480 |
    mgh |
|
1.47 |
0.61, 3.58 |
0.390 |
    michigan |
|
4.68 |
1.84, 11.9 |
0.001 |
    oschner |
|
2.45 |
0.93, 6.45 |
0.069 |
    rochester |
|
0.84 |
0.30, 2.39 |
0.750 |
    usc |
|
0.49 |
0.12, 2.11 |
0.340 |
    yale |
|
2.68 |
1.03, 7.00 |
0.044 |
Competing risk Multivariate model 2 HRS cohort
Characteristic |
N |
HR |
95% CI |
p-value |
age_admission |
227 |
1.02 |
1.00, 1.04 |
0.067 |
meld_3 |
227 |
1.03 |
1.00, 1.05 |
0.023 |
etiology_cirrhosis |
227 |
|
|
|
    Alcohol |
|
— |
— |
|
    HCV |
|
1.20 |
0.66, 2.18 |
0.550 |
    Multifactorial |
|
0.62 |
0.24, 1.60 |
0.320 |
    NASH |
|
0.71 |
0.40, 1.23 |
0.220 |
    Other |
|
1.56 |
0.84, 2.90 |
0.160 |
hcc_admission |
227 |
|
|
|
    0 |
|
— |
— |
|
    1 |
|
1.67 |
1.00, 2.79 |
0.052 |
site |
227 |
|
|
|
    baylor |
|
— |
— |
|
    indiana |
|
0.67 |
0.18, 2.46 |
0.540 |
    jacksonville |
|
0.49 |
0.11, 2.12 |
0.340 |
    kentukey |
|
1.54 |
0.59, 4.00 |
0.380 |
    MCW |
|
1.36 |
0.49, 3.75 |
0.550 |
    mgh |
|
1.12 |
0.45, 2.79 |
0.800 |
    michigan |
|
3.01 |
1.08, 8.38 |
0.034 |
    oschner |
|
2.13 |
0.82, 5.59 |
0.120 |
    rochester |
|
0.80 |
0.27, 2.36 |
0.690 |
    usc |
|
0.48 |
0.11, 2.09 |
0.330 |
    yale |
|
2.47 |
0.99, 6.13 |
0.052 |
KM Plot HRS cohort
