Variable N Overall
N = 120
1
NA
N = 15
1
neoadjuvant systemic therapy
N = 51
1
primary surgery
N = 54
1
p-value2
Age at surgery 120



<0.001
    Mean (SD)
65.01 (12.61) 71.80 (16.59) 59.63 (11.31) 68.20 (10.61)
contraceptives 120



<0.001
    no
42 (35.00%) 4 (26.67%) 21 (41.18%) 17 (31.48%)
    not_registered
42 (35.00%) 11 (73.33%) 9 (17.65%) 22 (40.74%)
    yes
36 (30.00%) 0 (0.00%) 21 (41.18%) 15 (27.78%)
application of hrt 120



<0.001
    no
73 (60.83%) 8 (53.33%) 43 (84.31%) 22 (40.74%)
    not registered
22 (18.33%) 7 (46.67%) 3 (5.88%) 12 (22.22%)
    yes
25 (20.83%) 0 (0.00%) 5 (9.80%) 20 (37.04%)
nicotine 120



<0.001
    no
82 (68.33%) 4 (26.67%) 36 (70.59%) 42 (77.78%)
    not registered
22 (18.33%) 10 (66.67%) 5 (9.80%) 7 (12.96%)
    previous
1 (0.83%) 0 (0.00%) 0 (0.00%) 1 (1.85%)
    yes
15 (12.50%) 1 (6.67%) 10 (19.61%) 4 (7.41%)
BMI (kg/m2) 120



0.006
    Mean (SD)
NA (NA) NA (NA) NA (NA) NA (4.64)
Palpable size 86



<0.001
    Mean (SD)
57.33 (24.81) 71.80 (24.08) 65.63 (19.13) 28.95 (10.70)
    Unknown
34 0 2 32
MRI primary 67



<0.001
    Mean (SD)
62.78 (27.64) 87.00 (26.03) 67.70 (21.64) 30.46 (20.84)
    Unknown
53 7 5 41
Grade 120



0.082
    Mean (SD)
NA (NA) NA (NA) NA (0.31) NA (0.36)
Metastasis to axilla 120



<0.001
    0
66 (55.00%) 7 (46.67%) 20 (39.22%) 39 (72.22%)
    1
52 (43.33%) 7 (46.67%) 31 (60.78%) 14 (25.93%)
    2
1 (0.83%) 1 (6.67%) 0 (0.00%) 0 (0.00%)
    5
1 (0.83%) 0 (0.00%) 0 (0.00%) 1 (1.85%)
ER+ 120 117 (97.50%) 13 (86.67%) 50 (98.04%) 54 (100.00%) 0.021
Her2+ 120 5 (4.17%) 0 (0.00%) 4 (7.84%) 1 (1.85%) 0.3
TN 120 2 (1.67%) 2 (13.33%) 0 (0.00%) 0 (0.00%) 0.015
Ki67 (%) 120



0.6
    Mean (SD)
NA (NA) NA (NA) NA (NA) NA (NA)
bct 120 34 (28.33%) 0 (0.00%) 5 (9.80%) 29 (53.70%) <0.001
mastectomy 120 74 (61.67%) 0 (0.00%) 47 (92.16%) 27 (50.00%) <0.001
Tumour size on histology (mm) 96



<0.001
    Mean (SD)
34.96 (28.21) NA (NA) 51.77 (30.68) 20.73 (15.45)
    Unknown
24 15 7 2
breast cancer related event 120



<0.001
    0
90 (75.00%) 5 (33.33%) 43 (84.31%) 42 (77.78%)
    1
30 (25.00%) 10 (66.67%) 8 (15.69%) 12 (22.22%)
metastasis 120



<0.001
    0
96 (80.00%) 5 (33.33%) 44 (86.27%) 47 (87.04%)
    1
24 (20.00%) 10 (66.67%) 7 (13.73%) 7 (12.96%)
Recurrence 120 6 (5.00%) 0 (0.00%) 0 (0.00%) 6 (11.11%) 0.020
mors 120 25 (20.83%) 13 (86.67%) 8 (15.69%) 4 (7.41%) <0.001
1 n (%)
2 Kruskal-Wallis rank sum test; Fisher’s exact test; Pearson’s Chi-squared test