MGH Period 1 vs 2

Balance check after

## Balance Measures
##                      Type M.0.Adj SD.0.Adj M.1.Adj SD.1.Adj Diff.Adj
## Age               Contin. 70.0859  12.6766 71.3427  11.4548   0.1041
## Race_Group_White   Binary  0.6126        .  0.6682        .   0.0556
## Race_Group_Black   Binary  0.1347        .  0.1699        .   0.0352
## Race_Group_Others  Binary  0.2527        .  0.1619        .  -0.0908
## Gender_Male        Binary  0.5681        .  0.6281        .   0.0600
## HTN_Y              Binary  0.9883        .  0.9776        .  -0.0107
## DM_Y               Binary  0.7274        .  0.7325        .   0.0051
## HF_score_Total    Contin. 42.1346   7.0990 39.9134   8.2954  -0.2942
## Dialysis_Vintage  Contin.  2.1748   1.4157  3.8131   3.8563   0.6789
## Access_type_AVF    Binary  0.6028        .  0.5369        .  -0.0659
## Access_type_AVG    Binary  0.0673        .  0.1388        .   0.0714
## Access_type_TDC    Binary  0.3299        .  0.3243        .  -0.0056
## Location_HH        Binary  0.4545        .  0.0705        .  -0.3840
## 
## Effective sample sizes
##                1      2
## Unadjusted 141.  223.  
## Adjusted   126.2 177.63

Univariate linear regression outcome los

outcome los

Characteristic	N	Beta	95% CI1	p-value
time	1,053
1		—	—
2		-1.9	-3.8, 0.02	0.053
Gender	1,053
Female		—	—
Male		0.12	-1.6, 1.9	0.892
Race_Group	1,053
White		—	—
Black		-0.88	-3.2, 1.5	0.466
Others		-0.70	-2.9, 1.5	0.541
DM	1,053
N		—	—
Y		-0.55	-2.5, 1.4	0.573
Dialysis_Vintage	1,053	-0.21	-0.46, 0.03	0.089
HF_score_Total	1,053	0.12	0.02, 0.23	0.020
weight.ATE	1,053	-0.25	-0.61, 0.11	0.169
1 CI = Confidence Interval

Univariate linear regression outcome log_los

outcome log_los

Characteristic	N	Beta	95% CI1	p-value
time	1,053
1		—	—
2		-18.74	-32.27, -2.52	0.026
Gender	1,053
Female		—	—
Male		1.03	-14.49, 19.37	0.904
Race_Group	1,053
White		—	—
Black		-16.02	-32.99, 5.25	0.130
Others		-13.02	-29.69, 7.60	0.200
DM	1,053
N		—	—
Y		-1.77	-18.22, 17.99	0.849
Dialysis_Vintage	1,053	-0.45	-2.77, 1.93	0.710
HF_score_Total	1,053	0.87	-0.14, 1.90	0.092
weight.ATE	1,053	-0.06	-3.45, 3.45	0.974
1 CI = Confidence Interval

Multivariate linear regression los: gender race

outcome los

Characteristic	N	Beta	95% CI1	p-value
time
1	283	—	—
2	770	-1.9	-3.9, -0.03	0.048
Gender
Female	408	—	—
Male	644	0.18	-1.6, 1.9	0.838
Race_Group
White	688	—	—
Black	168	-0.84	-3.2, 1.5	0.488
Others	196	-0.90	-3.1, 1.3	0.434
1 CI = Confidence Interval

Multivariate linear regression log_los : gender race

outcome log_los

Characteristic	N	Beta	95% CI1	p-value
time
1	283	—	—
2	770	-19.53	-32.99, -3.36	0.021
Gender
Female	408	—	—
Male	644	1.55	-14.02, 19.94	0.856
Race_Group
White	688	—	—
Black	168	-15.59	-32.59, 5.69	0.140
Others	196	-14.99	-31.33, 5.24	0.137
1 CI = Confidence Interval

Multivariate linear regression los ： time+Gender+Race_Group+DM+Dialysis_Vintage+HF_score_Total

outcome los

Characteristic	N	Beta	95% CI1	p-value
time
1	283	—	—
2	770	-1.4	-3.4, 0.52	0.152
Gender
Female	408	—	—
Male	644	-0.08	-1.8, 1.7	0.927
Race_Group
White	688	—	—
Black	168	-0.22	-2.6, 2.2	0.858
Others	196	-0.92	-3.2, 1.3	0.420
DM
N	283	—	—
Y	770	-1.0	-3.0, 0.97	0.314
Dialysis_Vintage	1,053	-0.17	-0.44, 0.10	0.213
HF_score_Total	1,053	0.10	-0.01, 0.21	0.067
1 CI = Confidence Interval

Multivariate linear regression log_los ： time+Gender+Race_Group+DM+Dialysis_Vintage+HF_score_Total

outcome log_los

Characteristic	N	Beta	95% CI1	p-value
time
1	283	—	—
2	770	-0.21	-0.40, -0.02	0.031
Gender
Female	408	—	—
Male	644	0.00	-0.17, 0.17	0.994
Race_Group
White	688	—	—
Black	168	-0.14	-0.38, 0.09	0.219
Others	196	-0.16	-0.37, 0.06	0.150
DM
N	283	—	—
Y	770	-0.01	-0.20, 0.18	0.893
Dialysis_Vintage	1,053	0.00	-0.02, 0.03	0.763
HF_score_Total	1,053	0.01	0.00, 0.02	0.226
1 CI = Confidence Interval

90 days poisson regression: time

Characteristic	N	IRR1	95% CI1	p-value
time
1	283	—	—
2	770	0.89	0.74, 1.08	0.230
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

90 days poisson regression: time Gender Race_Group

Characteristic	N	IRR1	95% CI1	p-value
time
1	283	—	—
2	770	0.85	0.71, 1.04	0.103
Gender
Female	408	—	—
Male	644	1.38	1.15, 1.67	<0.001
Race_Group
White	688	—	—
Black	168	1.24	1.0, 1.54	0.051
Others	196	0.83	0.64, 1.05	0.129
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

90 days poisson regression： time+ Gender+Race_Group+DM+Dialysis_Vintage+HF_score_Total

Characteristic	N	IRR1	95% CI1	p-value
time
1	283	—	—
2	770	0.87	0.72, 1.06	0.156
Gender
Female	408	—	—
Male	644	1.43	1.19, 1.73	<0.001
Race_Group
White	688	—	—
Black	168	1.20	0.95, 1.49	0.120
Others	196	0.82	0.63, 1.04	0.105
DM
N	283	—	—
Y	770	1.13	0.92, 1.40	0.251
Dialysis_Vintage	1,053	0.96	0.94, 0.99	0.018
HF_score_Total	1,053	0.99	0.97, 1.00	0.010
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days poisson regression: time

Characteristic	N	IRR1	95% CI1	p-value
time
1	283	—	—
2	770	0.76	0.66, 0.88	<0.001
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days poisson regression： Age Gender Race_Group

Characteristic	N	IRR1	95% CI1	p-value
time
1	283	—	—
2	770	0.74	0.64, 0.86	<0.001
Gender
Female	408	—	—
Male	644	1.21	1.05, 1.39	0.009
Race_Group
White	688	—	—
Black	168	1.00	0.83, 1.20	0.994
Others	196	0.87	0.72, 1.05	0.151
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days poisson regression： time+Gender+Race_Group+DM+Dialysis_Vintage+HF_score_Total

Characteristic	N	IRR1	95% CI1	p-value
time
1	283	—	—
2	770	0.76	0.66, 0.89	<0.001
Gender
Female	408	—	—
Male	644	1.22	1.06, 1.41	0.006
Race_Group
White	688	—	—
Black	168	0.99	0.82, 1.20	0.946
Others	196	0.86	0.72, 1.04	0.123
DM
N	283	—	—
Y	770	1.13	0.96, 1.33	0.145
Dialysis_Vintage	1,053	0.97	0.95, 0.99	0.009
HF_score_Total	1,053	0.99	0.99, 1.00	0.176
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

Univariate coxph decongestion_time_days

Characteristic	N	HR1	95% CI1	p-value
time	1,053
1		—	—
2		0.96	0.76, 1.20	0.705
Gender	1,053
Female		—	—
Male		0.83	0.66, 1.04	0.106
Race_Group	1,053
White		—	—
Black		0.99	0.60, 1.62	0.958
Others		1.18	0.92, 1.52	0.202
DM	1,053
N		—	—
Y		1.31	0.96, 1.80	0.085
Dialysis_Vintage	1,053	0.99	0.94, 1.04	0.571
HF_score_Total	1,053	1.01	0.99, 1.03	0.354
weight.ATE	1,053	0.97	0.91, 1.04	0.403
1 HR = Hazard Ratio, CI = Confidence Interval

coxph decongestion_time_days :gender race

Characteristic	HR1	95% CI1	p-value
time
1	—	—
2	0.98	0.79, 1.22	0.864
Gender
Female	—	—
Male	0.83	0.67, 1.04	0.106
Race_Group
White	—	—
Black	1.01	0.63, 1.62	0.973
Others	1.16	0.90, 1.50	0.246
1 HR = Hazard Ratio, CI = Confidence Interval

coxph decongestion_time_days :time+Gender+Race_Group+DM+Dialysis_Vintage+HF_score_Total

Characteristic	HR1	95% CI1	p-value
time
1	—	—
2	0.98	0.79, 1.23	0.879
Gender
Female	—	—
Male	0.83	0.67, 1.03	0.090
Race_Group
White	—	—
Black	1.05	0.74, 1.51	0.779
Others	1.14	0.88, 1.48	0.310
HTN
N	—	—
Y	0.83	0.40, 1.70	0.609
DM
N	—	—
Y	1.30	1.00, 1.68	0.047
CAD
N	—	—
Y	0.77	0.51, 1.16	0.214
Dialysis_Vintage	1.01	0.97, 1.05	0.584
HF_score_Total	1.01	1.00, 1.03	0.139
1 HR = Hazard Ratio, CI = Confidence Interval

Competing risk Univariate cause specific 1st_readmission_180

Characteristic	N	HR1	95% CI1	p-value
time	1,053
1		—	—
2		0.00	0.00, 0.00	<0.001
Gender	1,053
Female		—	—
Male		406,183,979	122,812,806, 1,343,389,420	<0.001
Race_Group	1,053
White		—	—
Black		3.63	0.33, 40.0	0.292
Others		0.00	0.00, 0.00	<0.001
DM	1,053
N		—	—
Y		1.10	0.10, 12.5	0.937
Dialysis_Vintage	1,053	1.00	0.77, 1.29	0.990
HF_score_Total	1,053	1.06	1.00, 1.13	0.058
weight.ATE	1,053	0.26	0.05, 1.29	0.099
1 HR = Hazard Ratio, CI = Confidence Interval

Competing risk Multivariate cause specific 1st_readmission_180: time+Gender+Race_Group

Characteristic	HR1	95% CI1	p-value
time
1	—	—
2	0.00	0.00, 0.00	<0.001
Gender
Female	—	—
Male	1,117,530,345	324,006,882, 3,854,467,740	<0.001
Race_Group
White	—	—
Black	4.39	0.43, 44.6	0.211
Others	0.00	0.00, 0.00	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

Competing risk Multivariate cause specific 1st_readmission_180: time+Gender+Race_Group+DM+Dialysis_Vintage+HF_score_Total

Characteristic	HR1	95% CI1	p-value
time
1	—	—
2	0.00	0.00, 0.00	<0.001
Gender
Female	—	—
Male	920,811,268	249,532,066, 3,397,933,601	<0.001
Race_Group
White	—	—
Black	7.59	0.70, 82.6	0.096
Others	0.00	0.00, 0.00	<0.001
DM
N	—	—
Y	0.42	0.04, 4.23	0.463
Dialysis_Vintage	1.42	0.92, 2.19	0.110
HF_score_Total	1.08	0.94, 1.24	0.298
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate coxph time_1st_readmission_180

Characteristic	N	HR1	95% CI1	p-value
time	1,053
1		—	—
2		0.00	0.00, 0.00	<0.001
Gender	1,053
Female		—	—
Male		406,183,971	122,812,808, 1,343,389,352	<0.001
Race_Group	1,053
White		—	—
Black		3.63	0.33, 40.0	0.292
Others		0.00	0.00, 0.00	<0.001
DM	1,053
N		—	—
Y		1.10	0.10, 12.5	0.937
Dialysis_Vintage	1,053	1.00	0.77, 1.29	0.990
HF_score_Total	1,053	1.06	1.00, 1.13	0.058
weight.ATE	1,053	0.26	0.05, 1.29	0.099
1 HR = Hazard Ratio, CI = Confidence Interval

coxph time_1st_readmission_180: age gender race

Characteristic	HR1	95% CI1	p-value
time
1	—	—
2	0.00	0.00, 0.00	<0.001
Age	0.97	0.92, 1.03	0.304
Gender
Female	—	—
Male	481,484,471	148,532,200, 1,560,788,137	<0.001
Race_Group
White	—	—
Black	2.50	0.53, 11.8	0.247
Others	0.00	0.00, 0.00	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

coxph time_1st_readmission_180: time+Gender+Race_Group+DM+Dialysis_Vintage+HF_score_Total

Characteristic	HR1	95% CI1	p-value
time
1	—	—
2	0.00	0.00, 0.00	<0.001
Gender
Female	—	—
Male	920,811,331	249,532,087, 3,397,933,785	<0.001
Race_Group
White	—	—
Black	7.59	0.70, 82.6	0.096
Others	0.00	0.00, 0.00	<0.001
DM
N	—	—
Y	0.42	0.04, 4.23	0.463
Dialysis_Vintage	1.42	0.92, 2.19	0.110
HF_score_Total	1.08	0.94, 1.24	0.298
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate coxph decongestion_time_days

Characteristic	N	HR1	95% CI1	p-value
time	1,053
1		—	—
2		0.96	0.76, 1.20	0.705
Gender	1,053
Female		—	—
Male		0.83	0.66, 1.04	0.106
Race_Group	1,053
White		—	—
Black		0.99	0.60, 1.62	0.958
Others		1.18	0.92, 1.52	0.202
DM	1,053
N		—	—
Y		1.31	0.96, 1.80	0.085
Dialysis_Vintage	1,053	0.99	0.94, 1.04	0.571
HF_score_Total	1,053	1.01	0.99, 1.03	0.354
weight.ATE	1,053	0.97	0.91, 1.04	0.403
1 HR = Hazard Ratio, CI = Confidence Interval

coxph decongestion_time_days: age gender race

Characteristic	HR1	95% CI1	p-value
time
1	—	—
2	0.97	0.78, 1.21	0.809
Age	1.01	1.00, 1.02	0.233
Gender
Female	—	—
Male	0.84	0.67, 1.05	0.119
Race_Group
White	—	—
Black	1.07	0.69, 1.66	0.757
Others	1.18	0.92, 1.51	0.194
1 HR = Hazard Ratio, CI = Confidence Interval

coxph decongestion_time_days: time+Gender+Race_Group+DM+Dialysis_Vintage+HF_score_Total

Characteristic	HR1	95% CI1	p-value
time
1	—	—
2	1.00	0.80, 1.25	0.982
Gender
Female	—	—
Male	0.83	0.67, 1.03	0.088
Race_Group
White	—	—
Black	1.08	0.76, 1.53	0.665
Others	1.17	0.91, 1.51	0.222
DM
N	—	—
Y	1.29	1.00, 1.67	0.054
Dialysis_Vintage	1.01	0.97, 1.05	0.649
HF_score_Total	1.01	1.00, 1.03	0.173
1 HR = Hazard Ratio, CI = Confidence Interval

decongestion_time_days,n_90,n_180,time_1st_readmission_180

	1 (N=141)	2 (N=223)	Overall (N=364)
decongestion_time_days
Mean (SD)	4.75 (4.54)	4.62 (3.85)	4.67 (4.13)
Median [Q1,Q3]	3.00 [2.00,5.00]	4.00 [2.00,6.00]	4.00 [2.00,6.00]
n_90
Mean (SD)	0.603 (0.901)	0.507 (0.747)	0.544 (0.810)
Median [Q1,Q3]	0 [0,1.00]	0 [0,1.00]	0 [0,1.00]
n_180
Mean (SD)	1.08 (1.20)	0.780 (1.04)	0.896 (1.11)
Median [Q1,Q3]	1.00 [0,2.00]	1.00 [0,1.00]	1.00 [0,1.00]
time_1st_readmission_180
Mean (SD)	-148 (2230)	180 (0)	53.0 (1400)
Median [Q1,Q3]	180 [180,180]	180 [180,180]	180 [180,180]