Preliminary AI Findings Data Exploration

This report attempts to group the 2,455 participants that ever ever consented to the Northwestern ADRC into groups by their baseline clinical diagnosis, their clinical diagnosis at their last visit, and their pathologic diagnosis after death.

Current or Last Diagnosis Summary

Summary of the clinical diagnosis at every participant’s last visit

		Total	Pre-UDS3	UDS3
Total		2,455	1,920	535
	AD	452	381	71
	MCI	314	273	41
	Impaired Not MCI	0	0	0
	NC	663	442	221
	PPA	386	264	122
	FTD	84	42	42
	Other	548	516	32

Current or Final Diagnosis Summary by Baseline Diagnosis

Summary of the clinical diagnosis at every participant’s first visit in which a clinical diagnosis was assessed by the diagnosis at their last visit.

		AD at Final	MCI at Final	NC at Final	PPA at Final	FTD at Final	Other at Final	Unknown at Final
Total		452	314	663	386	84	548	8
	AD at Baseline	230	1	0	3	2	28	1
	MCI at Baseline	39	80	16	10	3	13	1
	Impaired Not MCI at Baseline	1	1	2	0	0	3	0
	NC at Baseline	22	46	431	0	0	17	3
	PPA at Baseline	0	0	0	285	0	6	0
	FTD at Baseline	4	0	0	3	74	70	1
	Other at Baseline	3	1	0	2	4	59	0
	Unknown at Baseline	153	185	214	83	1	352	2

Pathologic Diagnoses

Summary of deceased and autopsy status by pathological diagnosis

				Total	Pre-UDS3	UDS3
Total				2,455	1,920	535
	Deceased			971	845	126
		Autopsy Completed		678	598	80
			AD	489	435	54
			FTD	127	114	13
			NC	11	9	2
			Other	39	36	3
			Unknown	12	4	8
		Autopsy Not Expected		293	247	46
			Unknown	293	247	46
	Not Deceased			1,479	1,070	409

Clinical Diagnosis Summary at Baseline Vist

First Visit with a clinical diagnosis

First visit in witch a clinical diagnosis was assessed. For example, if the participant participated in 10 research visits, but their was no clinical diagnosis associated to the first 5, that participant’s first visit with a clinical diagnosis would be visit 6.

		Total	Pre-UDS3	UDS3
Total		2,455	1,906	549
	AD	265	202	63
	MCI	162	101	61
	Impaired Not MCI	7	5	2
	NC	519	283	236
	PPA	291	173	118
	FTD	152	112	40
	Other	69	46	23
	Unknown	990	984	6

First Baseline Visit

Clinical diagnosis at every participant’s first visit.

		Total	Pre-UDS3	UDS3
Total		2,455	1,920	535
	AD	213	153	60
	MCI	120	61	59
	Impaired Not MCI	5	3	2
	NC	338	108	230
	PPA	274	156	118
	FTD	140	100	40
	Other	57	37	20
	Unknown	1,308	1,302	6

Clinical Diagnosis Summary by Visit

Clinical diagnosis for every participant at every research visit.

		Total	Pre-UDS3	UDS3
Total		12,834	8,592	4,242
	AD	1,291	696	595
	MCI	640	298	342
	Impaired Not MCI	63	29	34
	NC	3,223	1,257	1,966
	PPA	1,457	567	890
	FTD	528	283	245
	Other	289	144	145
	Unknown	5,343	5,318	25