ARCHES and SDOH

ARCHES and SDOH


0) Summary

We have previously shown a core model capturing how ARCHES participants perceive the dementia risk system, and with an expanded number of models, shown that neighborhood risk (mean ADI of a model-building group) significantly affects the ways that participants perceive and build these models.

Here we ask: how can SDOH deepen this understanding?

So far:

1) mean SDOH of group can be quantified as significantly relating to the models that groups report (p~0.01, r-squared ~ 0.20)

2) I’ve run comparison charts showing which model components are particularly prevalent in high, mid, and low SDOH groups, and which are most different in prevalence between high and low SDOH groups

Still to do:

3) run a multivariate model asking how much of the resisual variance (after taking into account ADI) SDOH explains

1) Demographics of groups

Now adding SDOH (count, binary and intensity, although we will use only count going forward (others are non-signifnant).

For both ADI_level and SDOH_level, we use a cut at low = bottom 25%, mid = middle 50%, and high = top 25% percentiles, but also test at 20-60-20 at the bottom of the document.

Group n_people mean_age percent_female mean_education_years mean_ADI_N mean_SDOH_count mean_SDOH_binary mean_SDOH_intensity round model facilitator ADI_level SDOH_level
1 8 58.4 0.9 16.6 56.0 3.1 0.0 0.0 1 ./Arches-CLD-JFT-MS-17-03-23-Final.mdl JF ADIlow SDOHlow
2 11 59.6 1.0 15.7 59.0 5.5 0.3 0.1 1 ./Arches-GMB-Vensim-18-3-23-Final.mdl JF ADIlow SDOHmid
3 6 68.5 0.9 15.4 84.8 6.0 0.0 0.0 1 ./Arches-CLD.3.19.2023_MM-AW-final.mdl MM ADIhigh SDOHmid
4 6 67.8 1.0 15.8 74.2 3.5 0.0 0.0 1 ./CLD-19-03-23-G2_JF_RAM_6_Final.mdl JF ADImid SDOHlow
5 8 66.4 0.9 15.2 76.0 5.4 0.0 0.0 1 ./ARCHES GMB Vensim Number 01 03.24.2023_Final.mdl JF ADImid SDOHmid
6 7 69.0 0.9 15.2 62.2 5.9 0.1 0.0 1 ./ARCHES GMB Vensim Number 02 03.24.2023_MS&AW-Final.mdl MS ADIlow SDOHmid
7 7 68.6 0.9 16.0 89.7 4.0 0.1 0.0 1 ./ARCHES GMB Vensim Number 01-AW-WZ-03.25.2023_Final.mdl AW ADIhigh SDOHmid
8 6 60.2 1.0 14.2 74.5 5.3 0.0 0.0 1 ./ARCHES-GMB-JFT-NR-03-25-23-Final.mdl JF ADImid SDOHmid
9 5 62.4 0.8 13.2 77.0 11.4 0.4 0.2 2 ./Arches-GMB-Standardized-JFT-Ram-05-03-24-Final.mdl JF ADImid SDOHhigh
10 7 69.7 1.0 14.7 62.7 6.3 0.0 0.0 2 ./ARCHES-GMB-AW-CC-05-03-24-Final.mdl AW ADIlow SDOHmid
11 5 63.4 0.9 14.8 73.4 6.6 0.2 0.1 2 ./ARCHES-GMB-Standardised-AW-MM-05-0424-final.mdl AW ADImid SDOHmid
12 4 57.8 0.5 18.0 49.8 5.5 0.0 0.0 2 ./Standardized ARCHES-05-05-24-Meena,JF,Chen-final.mdl JF ADIlow SDOHmid
13 6 64.0 1.0 15.5 73.3 3.0 0.0 0.0 2 ./ARCHES-GMB-5.5.24-AW-Ram-standardized-final.mdl AW ADImid SDOHlow
14 8 68.5 0.9 14.9 72.0 3.8 0.0 0.0 2 ./May 10 JF_chen.mdl JF ADImid SDOHlow
15 8 61.4 1.0 13.9 69.6 5.9 0.1 0.0 2 ./ARCHES051024.mdl AW ADIlow SDOHmid
16 7 59.6 0.9 14.6 72.7 8.3 0.1 0.1 2 ./GMB_Vesim Diagram_05112024_Shuya (1).mdl JF ADImid SDOHhigh
17 7 65.3 1.0 17.3 79.4 3.6 0.0 0.0 2 ./ARCHES_workshop_5.11.24_AWgroup.mdl AW ADImid SDOHlow
18 6 66.3 1.0 14.0 83.2 5.2 0.0 0.0 2 ./Arches-GMB-YZ-JF-5-16-24-Final.mdl JF ADImid SDOHmid
19 5 64.4 1.0 16.8 86.6 4.2 0.0 0.0 2 ./Arches-GMB-05-16-24-AW&YZ-Final.mdl AW ADIhigh SDOHmid
20 8 62.4 0.5 13.2 76.4 9.4 0.2 0.1 2 ./Arches-GMB-Standardized-MS-MM-05.16.24-final.mdl MM ADImid SDOHhigh
21 5 60.0 1.0 14.2 74.0 9.8 0.4 0.2 2 ./Arches-GMB-5-17-24JF-Final.mdl JF ADImid SDOHhigh
22 8 72.8 0.9 14.8 81.4 5.6 0.1 0.0 2 ./Arches-GMB-Standardized-AW-T-05-17-24-Final-v2.mdl AW ADImid SDOHmid
23 6 74.8 1.0 17.2 71.3 2.8 0.0 0.0 2 ./Arches-GMB-Mario-05-1724-Final.mdl MM ADImid SDOHlow
24 6 69.8 1.0 16.3 87.2 5.5 0.0 0.0 2 ./Arches-GMB-5-18-24-JFT-MS-Final.mdl JF ADIhigh SDOHmid
25 7 68.4 1.0 15.6 91.9 3.4 0.0 0.0 2 ./ARCHES_GMB-5.18.24-AW&TB-Final.mdl AW ADIhigh SDOHlow
26 6 67.3 1.0 15.8 80.8 3.8 0.0 0.0 2 ./Arches-GMB-05-18Mario-Yiou-Final.mdl MM ADImid SDOHlow
27 3 66.7 0.5 14.7 63.3 9.3 0.3 0.2 3 ./ARCHES CLD 10_19_24_JFT_Mia_Updated_Final_11.13.24.mdl JF ADIlow SDOHhigh
28 8 58.0 1.0 14.0 64.5 11.5 0.6 0.2 3 ./ARCHES CLD 10_19_24_AW_Chen_updated_V4_Final_11.14.24.mdl AW ADIlow SDOHhigh
29 4 56.5 0.5 12.5 88.8 8.8 0.0 0.0 3 ./ARCHE CLD 10_19_24_Mario_JW_updated_Final_11.14.24.mdl MM ADIhigh SDOHhigh
30 6 62.8 1.0 14.7 69.5 6.5 0.2 0.1 3 ./ARCHES CLD 10_20_2024_JFT_Mia_Final_11.14.24.mdl JF ADIlow SDOHmid
31 5 58.6 1.0 14.8 82.2 7.8 0.4 0.2 3 ./ARCHES CLD 10_20_2024_AW_Chen_updated_final_11.14.24.mdl AW ADImid SDOHhigh
32 5 56.4 0.5 11.6 92.6 8.7 0.3 0.1 3 ./ARCHES CLD 10_20_24_MM_JW_V5_updated_Final_11.15..24.mdl MM ADIhigh SDOHhigh
33 8 66.8 1.0 16.1 84.3 7.3 0.3 0.1 3 ./ARCHES CLD 10_25_2024_JFT_Mia_Updated_Final_11.15.2024.mdl JF ADIhigh SDOHmid
34 8 72.6 1.0 14.4 84.2 4.0 0.1 0.0 3 ./ARCHES CLD 10_25_24_Alexis_Vishnu_Updated_Final_11_15.24.mdl AW ADIhigh SDOHmid
35 8 71.5 0.8 14.6 75.6 4.7 0.0 0.0 3 ./ARCHE CLD 10_25_24_Mario_Inema-JFT_Updated_final_11.15.24.mdl MM ADImid SDOHmid
36 6 68.3 1.0 14.7 77.0 3.2 0.0 0.0 3 ./ARCHES CLD 10_25_24_RS_TB_Updated_Final_11.15.2024.mdl RS ADImid SDOHlow

Fitting SDOH along wtih other characteristics of groups

We now add SDOH to our fit of various characteristics of model-building groups to the distances of models from one another in this NMMDS ordination space.

In the table below Pr(>r) is the fit pvalue, with asterisks indicating significance thresholds. r2 is the amount of variation explained by the factor. You can ignore NMDS1 and NMDS2 for now – this gives the coordinates in the NMMDS ordination where the centroid of a factor (or the middle of a vector) would be.

In summary:

We see that group means of ADI National and SDOH count both have significant (pval<0.05) and moderately strong (r-squared ~ 0.20 - 0.30) fit with where a group’s model falls in the ordination space.

Next steps:

This model is looking independently at the effecrts of each. It would be nice to see them in an additive models, as we show above that these two variables are not correlated (as so we might expect them to show different facets of variation). I’m currently working on this.


***VECTORS

                        NMDS1    NMDS2     r2 Pr(>r)   
n_people             -0.25072 -0.96806 0.0288  0.601   
mean_age             -0.14531  0.98939 0.1425  0.097 . 
percent_female        0.67518  0.73765 0.0643  0.352   
mean_education_years -0.81925  0.57344 0.0642  0.357   
mean_ADI_N            0.59858  0.80106 0.2967  0.002 **
mean_SDOH_count       0.24054 -0.97064 0.2051  0.018 * 
round                 0.99774 -0.06713 0.0332  0.580   
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
Permutation: free
Number of permutations: 999

If we break SDOH count (a continuous variable) into quantile levels (lowest 25%, middle 50%, highest 25%), we can see they each occupy distinct areas of the ordination space, although there is significant overlap (as expected, given that SDOH as a continuous variable only explains about 20% of the variation in models — that is, that there is still agreement on a core model across SDOH levels).

Here, each point is one group’s model, and distances between each pair of points are defined by the dis-similarity in the edges (indirect and direct) in those models. So, points that are relatively close together are groups that had similar models, points that are widely spaced apart had more dis-similar models. I’ve colored and drawn outlines around groups that fell into each of the three SDOH levels.

We may also characterize which components are relatively more common in SDOH categories, (i.e. what the differences in the actual models are that are driving the dissimilarity):

_____

Every edge that occurred in >75% of one or more SDOH level

This shows every edge that had high frequency (was reported by 75% or more of the groups) in at least one of the SDOH levels. Edges at the right were reported with high frequency across all levels. Edges with long great bars are ones with a large difference between the frequency with which they are reported by groups of the different SDOH levels.

_____

Edges with the greatest difference (at least 40%)

This shows edges that were maximally different (at least 40% difference) among the high and low SDOH levels.


TESTING THE ABOVE WITH 20-60-20 instead of 25-75-25

quantile levels (lowest 20%, middle 60%, highest 20%)

_____

Every edge that occurred in >75% of one or more SDOH level

This shows every edge that had high frequency, with 20-60-20 split of SDOH levels

_____

Edges with the greatest difference (at least 40%)

This shows edges that were maximally different (at least 40% difference) , with 20-60-20 split of SDOH levels.