Variables	Cohort 1					Cohort 2					Cohort 3					Cohort 4				Cohort 5				Cohort 6
Variables	Day 1 N = 6¹	Day 15 N = 6¹	Day 29 N = 6¹	Day 43 N = 6¹	Day 85 N = 6¹	Day 1 N = 6¹	Day 15 N = 5¹	Day 29 N = 5¹	Day 43 N = 6¹	Day 85 N = 6¹	Day 1 N = 6¹	Day 15 N = 6¹	Day 29 N = 6¹	Day 43 N = 6¹	Day 85 N = 6¹	Day 1 N = 6¹	Day 15 N = 6¹	Day 29 N = 6¹	Day 43 N = 5¹	Day 1 N = 6¹	Day 15 N = 6¹	Day 29 N = 5¹	Day 43 N = 1¹	Day 1 N = 6¹	Day 15 N = 6¹
Screening Assay
Negative	6 / 6 (100%)	1 / 6 (17%)	3 / 6 (50%)	3 / 6 (50%)	2 / 6 (33%)	5 / 6 (83%)	4 / 5 (80%)	4 / 5 (80%)	5 / 6 (83%)	0 / 6 (0%)	6 / 6 (100%)	4 / 6 (67%)	6 / 6 (100%)	6 / 6 (100%)	4 / 6 (67%)	4 / 6 (67%)	2 / 6 (33%)	4 / 6 (67%)	4 / 5 (80%)	3 / 6 (50%)	1 / 6 (17%)	2 / 5 (40%)	1 / 1 (100%)	5 / 6 (83%)	3 / 6 (50%)
Positive	0 / 6 (0%)	5 / 6 (83%)	3 / 6 (50%)	3 / 6 (50%)	4 / 6 (67%)	1 / 6 (17%)	1 / 5 (20%)	1 / 5 (20%)	1 / 6 (17%)	6 / 6 (100%)	0 / 6 (0%)	2 / 6 (33%)	0 / 6 (0%)	0 / 6 (0%)	2 / 6 (33%)	2 / 6 (33%)	4 / 6 (67%)	2 / 6 (33%)	1 / 5 (20%)	3 / 6 (50%)	5 / 6 (83%)	3 / 5 (60%)	0 / 1 (0%)	1 / 6 (17%)	3 / 6 (50%)
missing	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 5 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 1 (0%)	0 / 6 (0%)	0 / 6 (0%)
Confirmator Assay
Negative	0 / 6 (0%)	0 / 6 (0%)	1 / 6 (17%)	0 / 6 (0%)	0 / 6 (0%)	1 / 6 (17%)	1 / 5 (20%)	1 / 5 (20%)	1 / 6 (17%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	2 / 6 (33%)	1 / 6 (17%)	1 / 5 (20%)	2 / 6 (33%)	5 / 6 (83%)	3 / 5 (60%)	0 / 1 (0%)	0 / 6 (0%)	2 / 6 (33%)
Positive	0 / 6 (0%)	5 / 6 (83%)	2 / 6 (33%)	3 / 6 (50%)	4 / 6 (67%)	0 / 6 (0%)	0 / 5 (0%)	0 / 5 (0%)	0 / 6 (0%)	6 / 6 (100%)	0 / 6 (0%)	2 / 6 (33%)	0 / 6 (0%)	0 / 6 (0%)	2 / 6 (33%)	2 / 6 (33%)	2 / 6 (33%)	1 / 6 (17%)	0 / 5 (0%)	1 / 6 (17%)	0 / 6 (0%)	0 / 5 (0%)	0 / 1 (0%)	1 / 6 (17%)	1 / 6 (17%)
missing	6 / 6 (100%)	1 / 6 (17%)	3 / 6 (50%)	3 / 6 (50%)	2 / 6 (33%)	5 / 6 (83%)	4 / 5 (80%)	4 / 5 (80%)	5 / 6 (83%)	0 / 6 (0%)	6 / 6 (100%)	4 / 6 (67%)	6 / 6 (100%)	6 / 6 (100%)	4 / 6 (67%)	4 / 6 (67%)	2 / 6 (33%)	4 / 6 (67%)	4 / 5 (80%)	3 / 6 (50%)	1 / 6 (17%)	2 / 5 (40%)	1 / 1 (100%)	5 / 6 (83%)	3 / 6 (50%)
Pre-existing Immune-reactivity
Negative	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	5 / 5 (100%)	5 / 5 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	4 / 6 (67%)	4 / 6 (67%)	4 / 6 (67%)	4 / 5 (80%)	5 / 6 (83%)	5 / 6 (83%)	4 / 5 (80%)	1 / 1 (100%)	6 / 6 (100%)	6 / 6 (100%)
Postive	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 5 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	2 / 6 (33%)	2 / 6 (33%)	2 / 6 (33%)	1 / 5 (20%)	1 / 6 (17%)	1 / 6 (17%)	1 / 5 (20%)	0 / 1 (0%)	0 / 6 (0%)	0 / 6 (0%)
missing	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 5 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 1 (0%)	0 / 6 (0%)	0 / 6 (0%)
Treatment-emergent
Negative	0 / 6 (0%)	0 / 6 (0%)	1 / 6 (17%)	0 / 6 (0%)	0 / 6 (0%)	1 / 6 (17%)	1 / 5 (20%)	1 / 5 (20%)	1 / 6 (17%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	2 / 6 (33%)	3 / 6 (50%)	2 / 6 (33%)	1 / 5 (20%)	3 / 6 (50%)	5 / 6 (83%)	3 / 5 (60%)	0 / 1 (0%)	0 / 6 (0%)	2 / 6 (33%)
Positive	0 / 6 (0%)	5 / 6 (83%)	2 / 6 (33%)	3 / 6 (50%)	4 / 6 (67%)	0 / 6 (0%)	0 / 5 (0%)	0 / 5 (0%)	0 / 6 (0%)	6 / 6 (100%)	0 / 6 (0%)	2 / 6 (33%)	0 / 6 (0%)	0 / 6 (0%)	2 / 6 (33%)	0 / 6 (0%)	1 / 6 (17%)	0 / 6 (0%)	0 / 5 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 1 (0%)	1 / 6 (17%)	1 / 6 (17%)
missing	6 / 6 (100%)	1 / 6 (17%)	3 / 6 (50%)	3 / 6 (50%)	2 / 6 (33%)	5 / 6 (83%)	4 / 5 (80%)	4 / 5 (80%)	5 / 6 (83%)	0 / 6 (0%)	6 / 6 (100%)	4 / 6 (67%)	6 / 6 (100%)	6 / 6 (100%)	4 / 6 (67%)	4 / 6 (67%)	2 / 6 (33%)	4 / 6 (67%)	4 / 5 (80%)	3 / 6 (50%)	1 / 6 (17%)	2 / 5 (40%)	1 / 1 (100%)	5 / 6 (83%)	3 / 6 (50%)
Treatment-boosted
Negative	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	5 / 5 (100%)	5 / 5 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	6 / 6 (100%)	5 / 5 (100%)	6 / 6 (100%)	6 / 6 (100%)	5 / 5 (100%)	1 / 1 (100%)	6 / 6 (100%)	6 / 6 (100%)
missing	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 5 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 6 (0%)	0 / 6 (0%)	0 / 5 (0%)	0 / 1 (0%)	0 / 6 (0%)	0 / 6 (0%)
¹ n / N Non-missing (%)