| Variables |
Cohort 1, N = 30
|
Cohort 2, N = 28
|
Cohort 3, N = 30
|
Cohort 4, N = 23
|
Cohort 5, N = 18
|
Cohort 6, N = 12
|
|||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Day 1 N = 61 |
Day 15 N = 61 |
Day 29 N = 61 |
Day 43 N = 61 |
Day 85 N = 61 |
N | Day 1 N = 61 |
Day 15 N = 51 |
Day 29 N = 51 |
Day 43 N = 61 |
Day 85 N = 61 |
N | Day 1 N = 61 |
Day 15 N = 61 |
Day 29 N = 61 |
Day 43 N = 61 |
Day 85 N = 61 |
N | Day 1 N = 61 |
Day 15 N = 61 |
Day 29 N = 61 |
Day 43 N = 51 |
N | Day 1 N = 61 |
Day 15 N = 61 |
Day 29 N = 51 |
Day 43 N = 11 |
N | Day 1 N = 61 |
Day 15 N = 61 |
|
| Screening Assay | 30 | 28 | 30 | 23 | 18 | 12 | |||||||||||||||||||||||||
| Negative | 6 / 6 (100%) | 1 / 6 (17%) | 3 / 6 (50%) | 3 / 6 (50%) | 2 / 6 (33%) | 5 / 6 (83%) | 4 / 5 (80%) | 4 / 5 (80%) | 5 / 6 (83%) | 0 / 6 (0%) | 6 / 6 (100%) | 4 / 6 (67%) | 6 / 6 (100%) | 6 / 6 (100%) | 4 / 6 (67%) | 4 / 6 (67%) | 2 / 6 (33%) | 4 / 6 (67%) | 4 / 5 (80%) | 3 / 6 (50%) | 1 / 6 (17%) | 2 / 5 (40%) | 1 / 1 (100%) | 5 / 6 (83%) | 3 / 6 (50%) | ||||||
| Positive | 0 / 6 (0%) | 5 / 6 (83%) | 3 / 6 (50%) | 3 / 6 (50%) | 4 / 6 (67%) | 1 / 6 (17%) | 1 / 5 (20%) | 1 / 5 (20%) | 1 / 6 (17%) | 6 / 6 (100%) | 0 / 6 (0%) | 2 / 6 (33%) | 0 / 6 (0%) | 0 / 6 (0%) | 2 / 6 (33%) | 2 / 6 (33%) | 4 / 6 (67%) | 2 / 6 (33%) | 1 / 5 (20%) | 3 / 6 (50%) | 5 / 6 (83%) | 3 / 5 (60%) | 0 / 1 (0%) | 1 / 6 (17%) | 3 / 6 (50%) | ||||||
| missing | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 1 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | ||||||
| Confirmator Assay | 30 | 28 | 30 | 23 | 18 | 12 | |||||||||||||||||||||||||
| Negative | 0 / 6 (0%) | 0 / 6 (0%) | 1 / 6 (17%) | 0 / 6 (0%) | 0 / 6 (0%) | 1 / 6 (17%) | 1 / 5 (20%) | 1 / 5 (20%) | 1 / 6 (17%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 2 / 6 (33%) | 1 / 6 (17%) | 1 / 5 (20%) | 2 / 6 (33%) | 5 / 6 (83%) | 3 / 5 (60%) | 0 / 1 (0%) | 0 / 6 (0%) | 2 / 6 (33%) | ||||||
| Positive | 0 / 6 (0%) | 5 / 6 (83%) | 2 / 6 (33%) | 3 / 6 (50%) | 4 / 6 (67%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 6 / 6 (100%) | 0 / 6 (0%) | 2 / 6 (33%) | 0 / 6 (0%) | 0 / 6 (0%) | 2 / 6 (33%) | 2 / 6 (33%) | 2 / 6 (33%) | 1 / 6 (17%) | 0 / 5 (0%) | 1 / 6 (17%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 1 (0%) | 1 / 6 (17%) | 1 / 6 (17%) | ||||||
| missing | 6 / 6 (100%) | 1 / 6 (17%) | 3 / 6 (50%) | 3 / 6 (50%) | 2 / 6 (33%) | 5 / 6 (83%) | 4 / 5 (80%) | 4 / 5 (80%) | 5 / 6 (83%) | 0 / 6 (0%) | 6 / 6 (100%) | 4 / 6 (67%) | 6 / 6 (100%) | 6 / 6 (100%) | 4 / 6 (67%) | 4 / 6 (67%) | 2 / 6 (33%) | 4 / 6 (67%) | 4 / 5 (80%) | 3 / 6 (50%) | 1 / 6 (17%) | 2 / 5 (40%) | 1 / 1 (100%) | 5 / 6 (83%) | 3 / 6 (50%) | ||||||
| Pre-existing Immune-reactivity | 30 | 28 | 30 | 23 | 18 | 12 | |||||||||||||||||||||||||
| Negative | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 5 / 5 (100%) | 5 / 5 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 4 / 6 (67%) | 4 / 6 (67%) | 4 / 6 (67%) | 4 / 5 (80%) | 5 / 6 (83%) | 5 / 6 (83%) | 4 / 5 (80%) | 1 / 1 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | ||||||
| Postive | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 2 / 6 (33%) | 2 / 6 (33%) | 2 / 6 (33%) | 1 / 5 (20%) | 1 / 6 (17%) | 1 / 6 (17%) | 1 / 5 (20%) | 0 / 1 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | ||||||
| missing | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 1 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | ||||||
| Treatment-emergent | 30 | 28 | 30 | 23 | 18 | 12 | |||||||||||||||||||||||||
| Negative | 0 / 6 (0%) | 0 / 6 (0%) | 1 / 6 (17%) | 0 / 6 (0%) | 0 / 6 (0%) | 1 / 6 (17%) | 1 / 5 (20%) | 1 / 5 (20%) | 1 / 6 (17%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 2 / 6 (33%) | 3 / 6 (50%) | 2 / 6 (33%) | 1 / 5 (20%) | 3 / 6 (50%) | 5 / 6 (83%) | 3 / 5 (60%) | 0 / 1 (0%) | 0 / 6 (0%) | 2 / 6 (33%) | ||||||
| Positive | 0 / 6 (0%) | 5 / 6 (83%) | 2 / 6 (33%) | 3 / 6 (50%) | 4 / 6 (67%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 6 / 6 (100%) | 0 / 6 (0%) | 2 / 6 (33%) | 0 / 6 (0%) | 0 / 6 (0%) | 2 / 6 (33%) | 0 / 6 (0%) | 1 / 6 (17%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 1 (0%) | 1 / 6 (17%) | 1 / 6 (17%) | ||||||
| missing | 6 / 6 (100%) | 1 / 6 (17%) | 3 / 6 (50%) | 3 / 6 (50%) | 2 / 6 (33%) | 5 / 6 (83%) | 4 / 5 (80%) | 4 / 5 (80%) | 5 / 6 (83%) | 0 / 6 (0%) | 6 / 6 (100%) | 4 / 6 (67%) | 6 / 6 (100%) | 6 / 6 (100%) | 4 / 6 (67%) | 4 / 6 (67%) | 2 / 6 (33%) | 4 / 6 (67%) | 4 / 5 (80%) | 3 / 6 (50%) | 1 / 6 (17%) | 2 / 5 (40%) | 1 / 1 (100%) | 5 / 6 (83%) | 3 / 6 (50%) | ||||||
| Treatment-boosted | 30 | 28 | 30 | 23 | 18 | 12 | |||||||||||||||||||||||||
| Negative | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 5 / 5 (100%) | 5 / 5 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 5 / 5 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | 5 / 5 (100%) | 1 / 1 (100%) | 6 / 6 (100%) | 6 / 6 (100%) | ||||||
| missing | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | 0 / 5 (0%) | 0 / 1 (0%) | 0 / 6 (0%) | 0 / 6 (0%) | ||||||
| 1 n / N Non-missing (%) | |||||||||||||||||||||||||||||||