read data

Table 1 before matching

#Table 1 after matching

After matching
0
(N=158)		 1
(N=404)		 Overall
(N=562)
Gender_Legal_Sex
Female 80 (51 %) 204 (50 %) 284 (51 %)
Male 78 (49 %) 200 (50 %) 278 (49 %)
age_bl
Mean (SD) 71 (± 15) 72 (± 14) 72 (± 15)
htn
0 51 (32 %) 84 (21 %) 135 (24 %)
1 107 (68 %) 320 (79 %) 427 (76 %)
dm
0 97 (61 %) 219 (54 %) 316 (56 %)
1 61 (39 %) 185 (46 %) 246 (44 %)
cad
0 98 (62 %) 218 (54 %) 316 (56 %)
1 60 (38 %) 186 (46 %) 246 (44 %)
chf
0 150 (95 %) 374 (93 %) 524 (93 %)
1 8 (5 %) 30 (7 %) 38 (7 %)
copd
0 145 (92 %) 361 (89 %) 506 (90 %)
1 13 (8 %) 43 (11 %) 56 (10 %)
nsaid
0 137 (87 %) 336 (83 %) 473 (84 %)
1 21 (13 %) 68 (17 %) 89 (16 %)
beta_blockers
0 112 (71 %) 253 (63 %) 365 (65 %)
1 46 (29 %) 151 (37 %) 197 (35 %)
statins
0 113 (72 %) 238 (59 %) 351 (62 %)
1 45 (28 %) 166 (41 %) 211 (38 %)
ace_arb
0 111 (70 %) 245 (61 %) 356 (63 %)
1 47 (30 %) 159 (39 %) 206 (37 %)
ppi
0 125 (79 %) 299 (74 %) 424 (75 %)
1 33 (21 %) 105 (26 %) 138 (25 %)
diur
0 115 (73 %) 265 (66 %) 380 (68 %)
1 43 (27 %) 139 (34 %) 182 (32 %)
immunosuppressant
0 150 (95 %) 384 (95 %) 534 (95 %)
1 8 (5 %) 20 (5 %) 28 (5 %)
renal_group2
eGFR 45-59.9, no ESKD 95 (60 %) 240 (59 %) 335 (60 %)
eGFR <30, no ESKD 12 (8 %) 32 (8 %) 44 (8 %)
eGFR 30-44.9, no ESKD 37 (23 %) 90 (22 %) 127 (23 %)
ESKD 14 (9 %) 42 (10 %) 56 (10 %)
cancer
0 121 (77 %) 275 (68 %) 396 (70 %)
1 37 (23 %) 129 (32 %) 166 (30 %)
pre_cre_freq_cat
1 60 (38 %) 117 (29 %) 177 (31 %)
2-4 52 (33 %) 147 (36 %) 199 (35 %)
5+ 46 (29 %) 140 (35 %) 186 (33 %)
pre_inpt_freq_cat
0 117 (74 %) 296 (73 %) 413 (73 %)
1-2 22 (14 %) 55 (14 %) 77 (14 %)
3+ 19 (12 %) 53 (13 %) 72 (13 %)
sglt2i
0 149 (94 %) 378 (94 %) 527 (94 %)
1 9 (6 %) 26 (6 %) 35 (6 %)
ccb
0 118 (75 %) 281 (70 %) 399 (71 %)
1 40 (25 %) 123 (30 %) 163 (29 %)
pre_HGB_365days_cat
Missing 8 (5 %) 27 (7 %) 35 (6 %)
Q1 35 (22 %) 101 (25 %) 136 (24 %)
Q2 32 (20 %) 88 (22 %) 120 (21 %)
Q3 34 (22 %) 85 (21 %) 119 (21 %)
Q4 49 (31 %) 103 (25 %) 152 (27 %)
pre_ALB_365days_cat
Missing 20 (13 %) 56 (14 %) 76 (14 %)
Q1 67 (42 %) 144 (36 %) 211 (38 %)
Q2 21 (13 %) 64 (16 %) 85 (15 %)
Q3 31 (20 %) 82 (20 %) 113 (20 %)
Q4 19 (12 %) 58 (14 %) 77 (14 %)
pre_WBC_365days_cat
Missing 8 (5 %) 27 (7 %) 35 (6 %)
Q1 64 (41 %) 126 (31 %) 190 (34 %)
Q2 26 (16 %) 81 (20 %) 107 (19 %)
Q3 27 (17 %) 82 (20 %) 109 (19 %)
Q4 33 (21 %) 88 (22 %) 121 (22 %)
pre_sodium_365days_cat
Missing 0 (0 %) 2 (0 %) 2 (0 %)
Q1 67 (42 %) 151 (37 %) 218 (39 %)
Q2 32 (20 %) 86 (21 %) 118 (21 %)
Q3 38 (24 %) 102 (25 %) 140 (25 %)
Q4 21 (13 %) 63 (16 %) 84 (15 %)
pre_potassium_365days_cat
Missing 2 (1 %) 9 (2 %) 11 (2 %)
Q1 49 (31 %) 126 (31 %) 175 (31 %)
Q2 34 (22 %) 84 (21 %) 118 (21 %)
Q3 36 (23 %) 93 (23 %) 129 (23 %)
Q4 37 (23 %) 92 (23 %) 129 (23 %)
factor(new_renal_outcome_status)
0 151 (96 %) 385 (95 %) 536 (95 %)
1 7 (4 %) 19 (5 %) 26 (5 %)
factor(new_dm_outcome_status)
0 156 (99 %) 399 (99 %) 555 (99 %)
1 2 (1 %) 5 (1 %) 7 (1 %)
factor(new_cv_outcome_status)
0 128 (81 %) 331 (82 %) 459 (82 %)
1 30 (19 %) 73 (18 %) 103 (18 %)
factor(hosp_outcome_30days_status)
0 138 (87 %) 369 (91 %) 507 (90 %)
1 20 (13 %) 35 (9 %) 55 (10 %)
factor(death_status_30)
0 147 (93 %) 400 (99 %) 547 (97 %)
1 11 (7 %) 4 (1 %) 15 (3 %)
factor(Critical_illness)
0 155 (98 %) 398 (99 %) 553 (98 %)
1 3 (2 %) 6 (1 %) 9 (2 %)
factor(death_status)
0 140 (89 %) 383 (95 %) 523 (93 %)
1 18 (11 %) 21 (5 %) 39 (7 %)

Model 1 cohort 913 Unviariate Logistic regression: hosp_outcome_30days_status

Characteristic N OR1 95% CI1 p-value
age_bl 913 1.02 1.00, 1.04 0.064
vaccine_ACTUAL 913


    0
— —
    1
0.66 0.40, 1.12 0.112
Gender_Legal_Sex 913


    Female
— —
    Male
1.01 0.65, 1.58 0.953
htn 913


    0
— —
    1
1.40 0.78, 2.70 0.283
dm 913


    0
— —
    1
1.34 0.86, 2.10 0.192
cad 913


    0
— —
    1
1.39 0.89, 2.19 0.144
chf 913


    0
— —
    1
1.39 0.67, 2.62 0.340
copd 913


    0
— —
    1
1.51 0.86, 2.55 0.136
1 OR = Odds Ratio, CI = Confidence Interval

Model 1 cohort 913 Multvariate logistic regression: hosp_outcome_30days_status

Characteristic N OR1 95% CI1 p-value
age_bl 913 1.02 1.00, 1.03 0.103
vaccine_ACTUAL 913


    0
— —
    1
0.54 0.32, 0.94 0.024
Gender_Legal_Sex 913


    Female
— —
    Male
0.97 0.62, 1.54 0.911
htn 913


    0
— —
    1
1.18 0.60, 2.46 0.634
dm 913


    0
— —
    1
1.25 0.78, 2.02 0.349
cad 913


    0
— —
    1
1.25 0.75, 2.07 0.391
chf 913


    0
— —
    1
1.10 0.51, 2.18 0.801
copd 913


    0
— —
    1
1.37 0.76, 2.39 0.274
1 OR = Odds Ratio, CI = Confidence Interval

Model 2 cohort 913 Unviariate Logistic regression: Critical_illness

Characteristic N OR1 95% CI1 p-value
age_bl 913 1.04 1.0, 1.10 0.106
vaccine_ACTUAL 913


    0
— —
    1
0.74 0.22, 3.38 0.660
Gender_Legal_Sex 913


    Female
— —
    Male
0.99 0.31, 3.18 0.985
htn 913


    0
— —
    1
1.20 0.31, 7.83 0.818
dm 913


    0
— —
    1
1.17 0.36, 3.75 0.792
cad 913


    0
— —
    1
1.47 0.47, 5.01 0.511
chf 913


    0
— —
    1
1.87 0.28, 7.24 0.423
copd 913


    0
— —
    1
1.74 0.38, 5.91 0.411
1 OR = Odds Ratio, CI = Confidence Interval

Model 2 cohort 913 Multvariate logistic regression: Critical_illness

Characteristic N OR1 95% CI1 p-value
age_bl 913 1.04 0.99, 1.10 0.122
vaccine_ACTUAL 913


    0
— —
    1
0.61 0.16, 2.92 0.480
Gender_Legal_Sex 913


    Female
— —
    Male
0.98 0.30, 3.22 0.971
htn 913


    0
— —
    1
0.85 0.16, 6.50 0.859
dm 913


    0
— —
    1
1.12 0.33, 3.98 0.851
cad 913


    0
— —
    1
1.25 0.33, 5.00 0.747
chf 913


    0
— —
    1
1.42 0.20, 6.49 0.675
copd 913


    0
— —
    1
1.50 0.31, 5.51 0.569
1 OR = Odds Ratio, CI = Confidence Interval

Model 3 cohort 913 Unviariate Logistic regression: death_status_30

Characteristic N OR1 95% CI1 p-value
age_bl 913 1.05 1.01, 1.09 0.010
vaccine_ACTUAL 913


    0
— —
    1
0.17 0.07, 0.37 <0.001
Gender_Legal_Sex 913


    Female
— —
    Male
1.60 0.73, 3.70 0.248
htn 913


    0
— —
    1
0.44 0.20, 1.04 0.050
dm 913


    0
— —
    1
0.42 0.16, 0.96 0.052
cad 913


    0
— —
    1
0.89 0.40, 1.96 0.780
chf 913


    0
— —
    1
0.77 0.12, 2.64 0.721
copd 913


    0
— —
    1
2.85 1.19, 6.38 0.013
1 OR = Odds Ratio, CI = Confidence Interval

Model 3 cohort 913 Multvariate logistic regression: death_status_30

Characteristic N OR1 95% CI1 p-value
age_bl 913 1.06 1.02, 1.10 0.005
vaccine_ACTUAL 913


    0
— —
    1
0.13 0.05, 0.33 <0.001
Gender_Legal_Sex 913


    Female
— —
    Male
1.67 0.73, 4.01 0.235
htn 913


    0
— —
    1
0.54 0.18, 1.62 0.268
dm 913


    0
— —
    1
0.46 0.16, 1.18 0.116
cad 913


    0
— —
    1
1.30 0.48, 3.59 0.601
chf 913


    0
— —
    1
0.74 0.11, 3.00 0.710
copd 913


    0
— —
    1
4.93 1.87, 12.7 <0.001
1 OR = Odds Ratio, CI = Confidence Interval

cohort 913 Forest plot for outcomes

## Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
## ℹ Please use `linewidth` instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.

Matched 562 Logistic regression hosp_outcome_30days_status

## Loading required package: zoo
## 
## Attaching package: 'zoo'
## The following objects are masked from 'package:base':
## 
##     as.Date, as.Date.numeric
##                   OR CI_Lower CI_Upper P_value
## vaccine_ACTUAL1 0.65     0.38     1.14    0.13

Matched 562 Logistic regression critical_illness 30 days

##                   OR CI_Lower CI_Upper P_value
## vaccine_ACTUAL1 0.78     0.21     2.88    0.71

Matched 562 Logistic regression death_status_30

##                   OR CI_Lower CI_Upper P_value
## vaccine_ACTUAL1 0.13     0.04     0.48  0.0021

Model3 Matched 562 Logistic regression new_cv_outcome_status

##                   OR CI_Lower CI_Upper P_value
## vaccine_ACTUAL1 0.94      0.6     1.48    0.79

Kaplan Meier 365 days