Table 1

#qc_check (correct)

Final data 1

Final data 2

Table 1 HRS_reversal_new

table1_check_0508_HRS_reversal_new

table1_check_0508_hrs_responders

table1_check_0508_hrs_responders_cat_2

table1_time_to_death_status_90days

table1_check_0508_HRS_criteria_3

followup HRS_reversal_new

HRS_reversal_new

hrs_responders

hrs_responders_cat_2

HRS_criteria_3

time_to_death_status_90days

Hospital Course Instrument table 1 HRS_reversal_new

hospitalization_course HRS_reversal_new

hospitalization_course hrs_responders

hospitalization_course hrs_responders_cat_2

hospitalization_course time_to_death_status_90days

hospitalization_course HRS_criteria_3

HRS Clinical Course Instrument

HRS_reversal_new

hrs_responders

hrs_responders_cat_2

HRS_criteria_3

time_to_death_status_90days

numerical_vars HRS_reversal_new

numerical_vars_formula <- as.formula(paste("~", paste(numerical_vars, collapse = "+"),"|HRS_reversal_new"))
table1(numerical_vars_formula,data = final_master)

	0 (N=168)	1 (N=75)	Overall (N=243)
age
Mean (SD)	56.4 (10.8)	55.7 (10.9)	56.2 (10.8)
Median [Min, Max]	58.0 [30.5, 79.1]	56.2 [28.3, 77.1]	57.6 [28.3, 79.1]
scr_admit
Mean (SD)	2.51 (1.15)	1.99 (0.974)	2.35 (1.13)
Median [Min, Max]	2.50 [0.340, 6.00]	1.76 [0.490, 6.70]	2.23 [0.340, 6.70]
Missing	5 (3.0%)	2 (2.7%)	7 (2.9%)
tbili_admit
Mean (SD)	11.4 (12.3)	8.82 (9.75)	10.6 (11.6)
Median [Min, Max]	5.35 [0.500, 55.7]	4.50 [0.400, 37.2]	5.00 [0.400, 55.7]
Missing	6 (3.6%)	2 (2.7%)	8 (3.3%)
inr_admit
Mean (SD)	2.05 (0.730)	1.88 (0.670)	1.99 (0.715)
Median [Min, Max]	1.90 [1.00, 4.90]	1.70 [1.10, 4.80]	1.80 [1.00, 4.90]
Missing	5 (3.0%)	2 (2.7%)	7 (2.9%)
sodium_admit
Mean (SD)	132 (6.59)	129 (6.53)	131 (6.69)
Median [Min, Max]	133 [113, 147]	130 [113, 143]	132 [113, 147]
Missing	7 (4.2%)	2 (2.7%)	9 (3.7%)
albumin_admit
Mean (SD)	3.13 (0.696)	3.07 (0.778)	3.11 (0.721)
Median [Min, Max]	3.00 [1.30, 5.00]	2.90 [1.70, 5.00]	3.00 [1.30, 5.00]
Missing	7 (4.2%)	2 (2.7%)	9 (3.7%)
lactate_admit
Mean (SD)	7.64 (23.7)	12.1 (36.1)	9.16 (28.5)
Median [Min, Max]	2.30 [0.500, 188]	2.80 [0.900, 180]	2.65 [0.500, 188]
Missing	93 (55.4%)	36 (48.0%)	129 (53.1%)
nsbb_dose_preadmission
Mean (SD)	26.2 (27.3)	30.0 (28.2)	27.5 (27.3)
Median [Min, Max]	12.5 [2.50, 100]	20.0 [6.25, 100]	16.3 [2.50, 100]
Missing	139 (82.7%)	60 (80.0%)	199 (81.9%)
mido_dose_preadmission
Mean (SD)	24.8 (15.3)	19.5 (12.9)	23.0 (14.6)
Median [Min, Max]	17.5 [5.00, 65.0]	15.0 [2.50, 45.0]	15.0 [2.50, 65.0]
Missing	116 (69.0%)	49 (65.3%)	165 (67.9%)
baseline_scr
Mean (SD)	1.58 (0.932)	1.18 (0.668)	1.46 (0.879)
Median [Min, Max]	1.35 [0.310, 5.31]	1.01 [0.400, 4.49]	1.24 [0.310, 5.31]
Missing	1 (0.6%)	0 (0%)	1 (0.4%)
baseline_scr_days_to_admit
Mean (SD)	41.0 (157)	30.6 (29.0)	37.8 (132)
Median [Min, Max]	13.5 [0, 1970]	23.0 [0, 108]	15.0 [0, 1970]
transfer_aki_days_toadmit
Mean (SD)	6.79 (6.01)	7.17 (7.63)	6.88 (6.38)
Median [Min, Max]	6.50 [0, 28.0]	3.00 [0, 28.0]	6.00 [0, 28.0]
Missing	110 (65.5%)	57 (76.0%)	167 (68.7%)
days_admit_to_aki
Mean (SD)	5.93 (30.4)	2.51 (4.29)	4.86 (25.4)
Median [Min, Max]	1.00 [0, 366]	1.00 [0, 20.0]	1.00 [0, 366]
Missing	3 (1.8%)	0 (0%)	3 (1.2%)
aki_weight
Mean (SD)	88.4 (23.0)	83.0 (22.1)	86.7 (22.8)
Median [Min, Max]	85.1 [45.2, 163]	83.0 [33.7, 145]	83.9 [33.7, 163]
Missing	1 (0.6%)	0 (0%)	1 (0.4%)
aki_height
Mean (SD)	170 (16.6)	169 (10.1)	170 (14.9)
Median [Min, Max]	170 [1.65, 201]	170 [145, 191]	170 [1.65, 201]
Missing	1 (0.6%)	0 (0%)	1 (0.4%)
aki_hr
Mean (SD)	88.4 (16.2)	93.0 (17.5)	89.8 (16.7)
Median [Min, Max]	89.0 [53.0, 128]	93.5 [53.0, 127]	90.0 [53.0, 128]
Missing	7 (4.2%)	1 (1.3%)	8 (3.3%)
aki_sbp
Mean (SD)	102 (15.9)	100 (17.1)	102 (16.3)
Median [Min, Max]	101 [53.0, 172]	98.0 [70.0, 150]	100 [53.0, 172]
Missing	7 (4.2%)	1 (1.3%)	8 (3.3%)
aki_dbp
Mean (SD)	58.0 (10.6)	57.7 (14.4)	57.9 (11.9)
Median [Min, Max]	57.0 [32.0, 96.0]	56.5 [16.0, 98.0]	57.0 [16.0, 98.0]
Missing	7 (4.2%)	1 (1.3%)	8 (3.3%)
aki_map
Mean (SD)	72.8 (10.9)	71.9 (13.5)	72.5 (11.8)
Median [Min, Max]	72.3 [39.0, 102]	69.7 [49.0, 114]	71.7 [39.0, 114]
Missing	7 (4.2%)	1 (1.3%)	8 (3.3%)
aki_pao2
Mean (SD)	94.0 (27.6)	89.1 (26.8)	92.4 (27.4)
Median [Min, Max]	86.0 [54.7, 150]	81.9 [48.7, 150]	86.0 [48.7, 150]
Missing	50 (29.8%)	18 (24.0%)	68 (28.0%)
fio2_aki
Mean (SD)	9.58 (10.4)	10.6 (15.4)	9.90 (12.1)
Median [Min, Max]	0.210 [0.210, 21.0]	0.290 [0.210, 100]	0.210 [0.210, 100]
Missing	17 (10.1%)	8 (10.7%)	25 (10.3%)
scr_aki
Mean (SD)	2.54 (1.05)	2.15 (0.966)	2.42 (1.04)
Median [Min, Max]	2.49 [0.950, 6.00]	1.90 [1.12, 8.00]	2.20 [0.950, 8.00]
bun_aki
Mean (SD)	47.8 (24.8)	42.1 (17.2)	46.0 (22.8)
Median [Min, Max]	41.3 [2.00, 146]	40.0 [12.0, 96.0]	40.0 [2.00, 146]
Missing	7 (4.2%)	0 (0%)	7 (2.9%)
albumin_aki
Mean (SD)	3.01 (0.679)	3.02 (0.710)	3.01 (0.688)
Median [Min, Max]	2.95 [1.20, 5.00]	2.95 [1.70, 4.50]	2.95 [1.20, 5.00]
Missing	16 (9.5%)	5 (6.7%)	21 (8.6%)
inr_aki
Mean (SD)	2.01 (0.673)	1.94 (0.725)	1.99 (0.688)
Median [Min, Max]	1.83 [1.00, 5.10]	1.70 [1.10, 4.80]	1.80 [1.00, 5.10]
Missing	26 (15.5%)	11 (14.7%)	37 (15.2%)
wbc_aki
Mean (SD)	11.1 (9.51)	10.2 (6.66)	10.9 (8.72)
Median [Min, Max]	9.23 [1.00, 100]	8.09 [1.20, 34.0]	8.40 [1.00, 100]
Missing	12 (7.1%)	5 (6.7%)	17 (7.0%)
plt_aki
Mean (SD)	121 (92.3)	127 (86.5)	123 (90.4)
Median [Min, Max]	90.0 [2.00, 533]	99.0 [17.0, 456]	94.5 [2.00, 533]
Missing	8 (4.8%)	3 (4.0%)	11 (4.5%)
ecg_qtc
Mean (SD)	453 (73.6)	453 (35.0)	453 (64.7)
Median [Min, Max]	460 [0.360, 670]	454 [386, 534]	457 [0.360, 670]
Missing	24 (14.3%)	16 (21.3%)	40 (16.5%)
days_to_echo
Mean (SD)	26.0 (50.4)	28.5 (71.8)	26.8 (58.1)
Median [Min, Max]	7.00 [0, 312]	3.00 [0, 370]	5.00 [0, 370]
Missing	49 (29.2%)	17 (22.7%)	66 (27.2%)
echo_ef
Mean (SD)	66.6 (6.20)	65.7 (5.96)	66.3 (6.12)
Median [Min, Max]	66.0 [53.0, 83.0]	65.0 [51.0, 78.0]	66.0 [51.0, 83.0]
Missing	45 (26.8%)	16 (21.3%)	61 (25.1%)
echo_lateral_e
Mean (SD)	11.3 (3.35)	11.1 (4.22)	11.2 (3.68)
Median [Min, Max]	11.0 [1.02, 18.4]	12.0 [0.140, 17.0]	11.0 [0.140, 18.4]
Missing	120 (71.4%)	46 (61.3%)	166 (68.3%)
echo_trpeak
Mean (SD)	156 (119)	145 (142)	152 (126)
Median [Min, Max]	220 [1.00, 305]	230 [2.10, 343]	225 [1.00, 343]
Missing	131 (78.0%)	56 (74.7%)	187 (77.0%)
echo_gls
Mean (SD)	-2.94 (23.7)	1.66 (23.9)	-1.63 (23.4)
Median [Min, Max]	-18.4 [-26.7, 40.0]	1.09 [-21.8, 26.1]	-18.4 [-26.7, 40.0]
Missing	148 (88.1%)	67 (89.3%)	215 (88.5%)
echo_earatio
Mean (SD)	1.27 (1.05)	1.13 (0.405)	1.22 (0.874)
Median [Min, Max]	1.05 [0.400, 9.10]	1.08 [0.600, 2.30]	1.05 [0.400, 9.10]
Missing	101 (60.1%)	37 (49.3%)	138 (56.8%)
echo_rvsp
Mean (SD)	34.1 (14.4)	34.9 (8.81)	34.4 (12.7)
Median [Min, Max]	33.0 [2.00, 82.0]	34.0 [22.0, 53.0]	33.0 [2.00, 82.0]
Missing	116 (69.0%)	48 (64.0%)	164 (67.5%)
echo_pasp
Mean (SD)	27.2 (19.7)	49.7 (33.7)	33.3 (25.5)
Median [Min, Max]	29.0 [3.00, 76.0]	39.0 [29.0, 117]	30.0 [3.00, 117]
Missing	152 (90.5%)	69 (92.0%)	221 (90.9%)
echo_lavi
Mean (SD)	32.1 (12.1)	34.4 (12.2)	32.8 (12.1)
Median [Min, Max]	32.0 [6.32, 69.0]	32.0 [15.0, 74.0]	32.0 [6.32, 74.0]
Missing	72 (42.9%)	30 (40.0%)	102 (42.0%)
echo_tr
Mean (SD)	11.2 (37.5)	61.2 (121)	29.5 (81.0)
Median [Min, Max]	2.60 [1.92, 166]	2.80 [2.10, 339]	2.64 [1.92, 339]
Missing	149 (88.7%)	64 (85.3%)	213 (87.7%)
totalalbumin_before_terli
Mean (SD)	237 (170)	269 (211)	247 (184)
Median [Min, Max]	200 [0.838, 1230]	206 [12.5, 1010]	200 [0.838, 1230]
Missing	20 (11.9%)	5 (6.7%)	25 (10.3%)
albvolume_before_terli
Mean (SD)	1030 (917)	1220 (987)	1090 (941)
Median [Min, Max]	800 [12.5, 8300]	1000 [150, 5650]	900 [12.5, 8300]
Missing	25 (14.9%)	10 (13.3%)	35 (14.4%)
saline_vol_before_terli
Mean (SD)	1190 (1310)	1150 (1070)	1170 (1220)
Median [Min, Max]	750 [8.00, 5400]	1000 [26.0, 5630]	1000 [8.00, 5630]
Missing	109 (64.9%)	43 (57.3%)	152 (62.6%)
lr_volume_before_terli
Mean (SD)	1990 (2440)	1570 (1320)	1860 (2150)
Median [Min, Max]	1470 [400, 15300]	1000 [500, 5000]	1250 [400, 15300]
Missing	126 (75.0%)	56 (74.7%)	182 (74.9%)
other_cryst_before_terli
Mean (SD)	1550 (2330)	NA (NA)	1550 (2330)
Median [Min, Max]	512 [83.0, 5680]	NA [NA, NA]	512 [83.0, 5680]
Missing	163 (97.0%)	75 (100%)	238 (97.9%)
prbc_qaunt_before_terli
Mean (SD)	3.51 (5.45)	2.51 (1.90)	3.21 (4.68)
Median [Min, Max]	2.00 [0, 33.0]	2.00 [1.00, 8.00]	2.00 [0, 33.0]
Missing	114 (67.9%)	52 (69.3%)	166 (68.3%)
totalvolume_before_terli
Mean (SD)	11000 (29700)	7650 (9860)	10000 (25400)
Median [Min, Max]	4680 [0, 284000]	4170 [240, 55400]	4650 [0, 284000]
Missing	22 (13.1%)	12 (16.0%)	34 (14.0%)
total_uo_before_terli
Mean (SD)	6300 (15000)	4710 (7020)	5820 (13100)
Median [Min, Max]	1960 [0, 116000]	2560 [0, 41400]	2100 [0, 116000]
Missing	26 (15.5%)	14 (18.7%)	40 (16.5%)
days_first_mido_before_terli
Mean (SD)	3.31 (8.44)	20.6 (102)	8.88 (58.4)
Median [Min, Max]	1.00 [0, 84.0]	1.00 [0, 727]	1.00 [0, 727]
Missing	50 (29.8%)	19 (25.3%)	69 (28.4%)
days_total_mido_before_terli
Mean (SD)	7.48 (13.8)	8.84 (10.9)	7.92 (12.9)
Median [Min, Max]	5.00 [0, 143]	5.50 [1.00, 64.0]	5.00 [0, 143]
Missing	51 (30.4%)	19 (25.3%)	70 (28.8%)
mido_maxdose_before_terli
10	12 (7.1%)	2 (2.7%)	14 (5.8%)
15	17 (10.1%)	5 (6.7%)	22 (9.1%)
20	10 (6.0%)	3 (4.0%)	13 (5.3%)
22.5	1 (0.6%)	0 (0%)	1 (0.4%)
25	2 (1.2%)	0 (0%)	2 (0.8%)
30	32 (19.0%)	17 (22.7%)	49 (20.2%)
35	1 (0.6%)	0 (0%)	1 (0.4%)
40	3 (1.8%)	1 (1.3%)	4 (1.6%)
45	22 (13.1%)	13 (17.3%)	35 (14.4%)
5	6 (3.6%)	0 (0%)	6 (2.5%)
50	1 (0.6%)	0 (0%)	1 (0.4%)
55	3 (1.8%)	1 (1.3%)	4 (1.6%)
60	4 (2.4%)	7 (9.3%)	11 (4.5%)
65	1 (0.6%)	0 (0%)	1 (0.4%)
7.5	1 (0.6%)	1 (1.3%)	2 (0.8%)
70	1 (0.6%)	0 (0%)	1 (0.4%)
75	1 (0.6%)	0 (0%)	1 (0.4%)
100	0 (0%)	1 (1.3%)	1 (0.4%)
105	0 (0%)	1 (1.3%)	1 (0.4%)
2.5	0 (0%)	2 (2.7%)	2 (0.8%)
90	0 (0%)	2 (2.7%)	2 (0.8%)
Missing	50 (29.8%)	19 (25.3%)	69 (28.4%)
days_first_oct_before_terli
Mean (SD)	7.41 (40.0)	5.50 (10.6)	6.84 (34.0)
Median [Min, Max]	1.00 [0, 371]	2.00 [0, 60.0]	1.00 [0, 371]
Missing	82 (48.8%)	39 (52.0%)	121 (49.8%)
days_total_oct_before_terli
Mean (SD)	7.47 (16.2)	8.58 (11.2)	7.80 (14.8)
Median [Min, Max]	3.00 [0, 143]	5.50 [0, 64.0]	4.00 [0, 143]
Missing	82 (48.8%)	39 (52.0%)	121 (49.8%)
oct_maxdose_before_terli
Mean (SD)	411 (381)	428 (377)	416 (378)
Median [Min, Max]	300 [50.0, 1250]	300 [50.0, 1200]	300 [50.0, 1250]
Missing	82 (48.8%)	39 (52.0%)	121 (49.8%)
days_first_ne_before_terli
Mean (SD)	2.70 (4.50)	1.64 (2.16)	2.35 (3.89)
Median [Min, Max]	1.00 [0, 18.0]	1.00 [0, 7.00]	1.00 [0, 18.0]
Missing	145 (86.3%)	64 (85.3%)	209 (86.0%)
days_total_ne_before_terli
Mean (SD)	7.96 (9.73)	8.73 (8.70)	8.21 (9.28)
Median [Min, Max]	4.00 [0, 34.0]	6.00 [1.00, 26.0]	4.00 [0, 34.0]
Missing	145 (86.3%)	64 (85.3%)	209 (86.0%)
days_to_gihep_consult
Mean (SD)	4.27 (30.5)	4.43 (12.8)	4.32 (26.3)
Median [Min, Max]	1.00 [0, 372]	1.00 [0, 89.0]	1.00 [0, 372]
Missing	18 (10.7%)	8 (10.7%)	26 (10.7%)
days_to_neph_consult
Mean (SD)	8.44 (42.2)	4.14 (5.32)	7.16 (35.5)
Median [Min, Max]	2.00 [0, 372]	2.00 [0, 25.0]	2.00 [0, 372]
Missing	15 (8.9%)	10 (13.3%)	25 (10.3%)
days_to_pall_consult
Mean (SD)	12.3 (15.2)	22.1 (40.2)	14.2 (22.1)
Median [Min, Max]	9.00 [0, 93.0]	11.0 [0, 162]	9.00 [0, 162]
Missing	103 (61.3%)	60 (80.0%)	163 (67.1%)
days_ua_hrs
Mean (SD)	3.57 (11.9)	4.74 (9.46)	3.92 (11.2)
Median [Min, Max]	1.00 [0, 140]	1.00 [0, 58.0]	1.00 [0, 140]
Missing	12 (7.1%)	7 (9.3%)	19 (7.8%)
days_ua_na_hrs
Mean (SD)	4.26 (12.5)	4.47 (9.31)	4.33 (11.5)
Median [Min, Max]	1.00 [0, 140]	1.00 [0, 58.0]	1.00 [0, 140]
Missing	25 (14.9%)	9 (12.0%)	34 (14.0%)
ua_na_value_hrs
Mean (SD)	19.7 (17.3)	19.9 (16.5)	19.7 (17.0)
Median [Min, Max]	19.0 [5.00, 140]	19.0 [9.00, 103]	19.0 [5.00, 140]
Missing	25 (14.9%)	9 (12.0%)	34 (14.0%)
days_ua_cr_hrs
Mean (SD)	5.15 (14.1)	6.77 (16.4)	5.68 (14.9)
Median [Min, Max]	1.50 [0, 143]	1.00 [0, 108]	1.00 [0, 143]
Missing	52 (31.0%)	18 (24.0%)	70 (28.8%)
ua_cr_value_hrs
Mean (SD)	138 (66.7)	142 (70.2)	140 (67.7)
Median [Min, Max]	127 [30.0, 418]	135 [27.4, 378]	128 [27.4, 418]
Missing	52 (31.0%)	18 (24.0%)	70 (28.8%)
days_ua_urea_hrs
Mean (SD)	4.48 (5.89)	4.59 (8.29)	4.52 (6.83)
Median [Min, Max]	2.00 [0, 23.0]	1.00 [0, 35.0]	1.00 [0, 35.0]
Missing	114 (67.9%)	43 (57.3%)	157 (64.6%)
ua_urea_value_hrs
Mean (SD)	536 (224)	506 (216)	525 (220)
Median [Min, Max]	517 [2.80, 1180]	474 [82.0, 923]	513 [2.80, 1180]
Missing	114 (67.9%)	43 (57.3%)	157 (64.6%)
feurea_hrs
Mean (SD)	26.1 (18.7)	21.0 (14.0)	24.2 (17.1)
Median [Min, Max]	24.3 [1.93, 124]	19.6 [4.32, 77.1]	21.2 [1.93, 124]
Missing	120 (71.4%)	46 (61.3%)	166 (68.3%)
ua_rbc_hrs
Mean (SD)	17.1 (34.3)	13.1 (27.6)	15.8 (32.4)
Median [Min, Max]	3.00 [0, 182]	2.00 [0, 151]	2.00 [0, 182]
Missing	39 (23.2%)	16 (21.3%)	55 (22.6%)
uaprotein_hrs
Mean (SD)	72.3 (131)	32.9 (114)	58.6 (126)
Median [Min, Max]	5.59 [0, 530]	0.525 [0, 730]	2.00 [0, 730]
Missing	89 (53.0%)	33 (44.0%)	122 (50.2%)
temp_terli_day0
Mean (SD)	36.9 (4.73)	36.7 (0.426)	36.8 (3.94)
Median [Min, Max]	36.6 [34.1, 97.5]	36.6 [35.6, 38.2]	36.6 [34.1, 97.5]
hr_terli_day0
Mean (SD)	78.1 (16.1)	80.8 (17.0)	79.0 (16.4)
Median [Min, Max]	79.0 [39.0, 124]	82.0 [45.0, 124]	80.0 [39.0, 124]
pao2_terli_day0
Mean (SD)	103 (53.8)	98.6 (26.0)	102 (46.9)
Median [Min, Max]	90.6 [49.0, 616]	86.0 [56.0, 150]	88.0 [49.0, 616]
Missing	41 (24.4%)	18 (24.0%)	59 (24.3%)
fio2_terli_day0
Mean (SD)	0.218 (0.0467)	0.231 (0.0886)	0.222 (0.0623)
Median [Min, Max]	0.210 [0.0197, 0.600]	0.210 [0.210, 0.730]	0.210 [0.0197, 0.730]
Missing	8 (4.8%)	7 (9.3%)	15 (6.2%)
sbp_terli_day0_time0
Mean (SD)	109 (15.6)	106 (12.4)	108 (14.7)
Median [Min, Max]	108 [80.0, 157]	103 [86.0, 141]	106 [80.0, 157]
Missing	17 (10.1%)	9 (12.0%)	26 (10.7%)
map_terli_day0_time0
Mean (SD)	69.3 (25.0)	65.8 (25.8)	68.2 (25.3)
Median [Min, Max]	73.3 [0, 138]	73.0 [0, 98.3]	73.2 [0, 138]
Missing	1 (0.6%)	0 (0%)	1 (0.4%)
chloride_terli_day0
Mean (SD)	101 (6.87)	99.8 (7.18)	100 (6.97)
Median [Min, Max]	101 [80.0, 119]	101 [80.0, 118]	101 [80.0, 119]
bicarb_terli_day0
Mean (SD)	18.4 (4.00)	19.8 (3.70)	18.8 (3.96)
Median [Min, Max]	19.0 [7.00, 32.0]	20.0 [12.0, 29.0]	19.0 [7.00, 32.0]
Missing	4 (2.4%)	1 (1.3%)	5 (2.1%)
scr_terli_day0
Mean (SD)	3.18 (0.973)	2.43 (0.733)	2.95 (0.968)
Median [Min, Max]	2.99 [1.23, 5.79]	2.29 [1.28, 5.02]	2.79 [1.23, 5.79]
bun_terli_day0
Mean (SD)	58.6 (24.0)	52.3 (23.5)	56.6 (24.0)
Median [Min, Max]	56.0 [5.00, 132]	49.0 [17.0, 145]	54.0 [5.00, 145]
Missing	2 (1.2%)	0 (0%)	2 (0.8%)
ast_terli_day0
Mean (SD)	72.1 (63.4)	60.0 (46.4)	68.4 (58.9)
Median [Min, Max]	55.0 [1.22, 405]	47.0 [12.0, 254]	51.5 [1.22, 405]
Missing	9 (5.4%)	6 (8.0%)	15 (6.2%)
alt_terli_day0
Mean (SD)	31.5 (28.3)	29.0 (27.4)	30.7 (28.0)
Median [Min, Max]	23.0 [4.00, 209]	21.0 [4.00, 169]	23.0 [4.00, 209]
Missing	9 (5.4%)	6 (8.0%)	15 (6.2%)
bili_terli_day0
Mean (SD)	12.5 (13.5)	9.37 (10.6)	11.6 (12.7)
Median [Min, Max]	6.10 [0.300, 57.3]	4.45 [0.800, 41.2]	5.60 [0.300, 57.3]
Missing	10 (6.0%)	5 (6.7%)	15 (6.2%)
alb_terli_day0
Mean (SD)	3.48 (0.547)	3.60 (0.550)	3.52 (0.550)
Median [Min, Max]	3.50 [2.10, 4.80]	3.60 [2.10, 5.00]	3.50 [2.10, 5.00]
Missing	11 (6.5%)	4 (5.3%)	15 (6.2%)
inr_terli_day0
Mean (SD)	2.27 (0.823)	2.08 (0.645)	2.21 (0.777)
Median [Min, Max]	2.15 [1.00, 6.90]	2.00 [1.20, 4.10]	2.10 [1.00, 6.90]
Missing	32 (19.0%)	16 (21.3%)	48 (19.8%)
wbc_terli_day0
Mean (SD)	9.64 (6.50)	8.28 (5.17)	9.22 (6.14)
Median [Min, Max]	7.89 [1.50, 41.3]	6.60 [2.80, 26.9]	7.30 [1.50, 41.3]
Missing	7 (4.2%)	2 (2.7%)	9 (3.7%)
hgb_terli_day0
Mean (SD)	8.35 (1.40)	8.36 (1.24)	8.35 (1.35)
Median [Min, Max]	8.00 [5.30, 12.9]	8.20 [6.20, 11.9]	8.00 [5.30, 12.9]
Missing	2 (1.2%)	2 (2.7%)	4 (1.6%)
Discont_Day
Mean (SD)	3.49 (2.78)	5.21 (3.09)	4.02 (2.98)
Median [Min, Max]	3.00 [1.00, 13.0]	4.00 [1.00, 13.0]	3.00 [1.00, 13.0]
na_terli_day0
Mean (SD)	133 (5.85)	132 (5.09)	132 (5.63)
Median [Min, Max]	133 [120, 147]	132 [119, 145]	133 [119, 147]
days_to_terli_initiation_day0
Mean (SD)	7.38 (12.4)	8.48 (9.75)	7.72 (11.6)
Median [Min, Max]	4.00 [0, 143]	6.00 [1.00, 64.0]	5.00 [0, 143]
clif_c_score
Mean (SD)	43.3 (8.26)	39.2 (7.80)	42.0 (8.32)
Median [Min, Max]	42.3 [19.6, 62.4]	38.9 [24.6, 58.4]	41.4 [19.6, 62.4]
Missing	7 (4.2%)	2 (2.7%)	9 (3.7%)
admit_meld
Mean (SD)	28.4 (7.73)	24.6 (7.20)	27.2 (7.75)
Median [Min, Max]	28.0 [8.00, 48.0]	24.0 [11.0, 39.0]	27.0 [8.00, 48.0]
Missing	6 (3.6%)	2 (2.7%)	8 (3.3%)
admit_meld_na
Mean (SD)	30.3 (6.66)	28.5 (5.88)	29.7 (6.47)
Median [Min, Max]	30.0 [12.0, 46.0]	28.5 [13.0, 39.0]	30.0 [12.0, 46.0]
Missing	8 (4.8%)	3 (4.0%)	11 (4.5%)
admit_meld_3
Mean (SD)	31.8 (7.68)	29.4 (6.63)	31.1 (7.44)
Median [Min, Max]	32.0 [5.00, 50.0]	30.0 [12.0, 41.0]	31.0 [5.00, 50.0]
admit_meld_3_raw
Mean (SD)	31.9 (7.87)	29.3 (6.71)	31.1 (7.60)
Median [Min, Max]	32.0 [5.00, 50.0]	30.0 [12.0, 41.0]	31.0 [5.00, 50.0]
Missing	8 (4.8%)	2 (2.7%)	10 (4.1%)
day0_meld
Mean (SD)	32.5 (7.23)	28.9 (7.35)	31.5 (7.44)
Median [Min, Max]	33.0 [17.0, 51.0]	29.0 [16.0, 44.0]	32.0 [16.0, 51.0]
Missing	35 (20.8%)	18 (24.0%)	53 (21.8%)
day0_meld_na
Mean (SD)	33.5 (6.52)	30.9 (6.42)	32.7 (6.59)
Median [Min, Max]	34.0 [18.0, 50.0]	31.0 [16.0, 44.0]	34.0 [16.0, 50.0]
Missing	35 (20.8%)	18 (24.0%)	53 (21.8%)
day0_meld_3
Mean (SD)	35.3 (7.77)	32.2 (7.53)	34.4 (7.81)
Median [Min, Max]	37.0 [13.0, 53.0]	33.0 [10.0, 45.0]	35.0 [10.0, 53.0]
Missing	38 (22.6%)	19 (25.3%)	57 (23.5%)
time_to_transplant
Mean (SD)	38.7 (48.3)	47.0 (52.3)	41.0 (49.2)
Median [Min, Max]	19.0 [4.00, 199]	21.0 [2.00, 167]	20.0 [2.00, 199]
Missing	117 (69.6%)	56 (74.7%)	173 (71.2%)
time_to_death_status
0	92 (54.8%)	48 (64.0%)	140 (57.6%)
1	76 (45.2%)	27 (36.0%)	103 (42.4%)
cystatinc_admit
Mean (SD)	2.98 (0.812)	2.84 (0.711)	2.94 (0.777)
Median [Min, Max]	2.93 [1.16, 4.20]	2.81 [1.80, 3.90]	2.89 [1.16, 4.20]
Missing	144 (85.7%)	66 (88.0%)	210 (86.4%)
cystatinc_aki
Mean (SD)	2.69 (0.934)	3.08 (0.883)	2.79 (0.914)
Median [Min, Max]	2.67 [1.23, 4.16]	3.02 [2.19, 4.10]	2.71 [1.23, 4.16]
Missing	154 (91.7%)	70 (93.3%)	224 (92.2%)
cystatinc_terli_day0
Mean (SD)	3.10 (1.26)	2.69 (0.720)	2.95 (1.10)
Median [Min, Max]	3.27 [0.239, 6.10]	2.87 [1.52, 3.90]	2.91 [0.239, 6.10]
Missing	151 (89.9%)	66 (88.0%)	217 (89.3%)
urine_pc
Mean (SD)	0.670 (1.27)	0.234 (0.710)	0.517 (1.12)
Median [Min, Max]	0.116 [0, 7.07]	0.0109 [0, 4.27]	0.0736 [0, 7.07]
Missing	100 (59.5%)	38 (50.7%)	138 (56.8%)
fena
Mean (SD)	0.549 (1.77)	0.405 (0.856)	0.501 (1.53)
Median [Min, Max]	0.217 [0.0228, 17.2]	0.175 [0.0498, 5.07]	0.211 [0.0228, 17.2]
Missing	62 (36.9%)	21 (28.0%)	83 (34.2%)
fena_hrs
Mean (SD)	0.541 (1.45)	0.424 (0.818)	0.502 (1.28)
Median [Min, Max]	0.243 [0.0327, 14.0]	0.176 [0.0469, 4.48]	0.220 [0.0327, 14.0]
Missing	57 (33.9%)	20 (26.7%)	77 (31.7%)
time_to_death_90days
Mean (SD)	57.0 (36.2)	66.8 (31.6)	60.0 (35.0)
Median [Min, Max]	90.0 [1.00, 90.0]	90.0 [3.00, 90.0]	90.0 [1.00, 90.0]
total_albumin
Mean (SD)	92.7 (99.6)	82.4 (108)	89.5 (102)
Median [Min, Max]	75.0 [0, 500]	50.0 [0, 700]	62.5 [0, 700]

num_hrs_clinical_course_variables HRS_reversal_new

num_hrs_clinical_course_variables_formula <- as.formula(paste("~", paste(num_hrs_clinical_course_variables, collapse = "+"),"|HRS_reversal_new"))
table1(num_hrs_clinical_course_variables_formula,data = final_master)

	0 (N=168)	1 (N=75)	Overall (N=243)
scr_day1_post_terli
Mean (SD)	3.10 (1.36)	1.30 (0.247)	2.53 (1.41)
Median [Min, Max]	2.67 [1.29, 8.84]	1.30 [0.700, 1.80]	2.15 [0.700, 8.84]
Missing	25 (14.9%)	8 (10.7%)	33 (13.6%)
scr_day2_post_terli
Mean (SD)	2.92 (1.32)	1.35 (0.344)	2.44 (1.33)
Median [Min, Max]	2.60 [1.24, 8.73]	1.32 [0.640, 2.44]	2.07 [0.640, 8.73]
Missing	35 (20.8%)	15 (20.0%)	50 (20.6%)
scr_day3_post_terli
Mean (SD)	2.75 (1.28)	1.38 (0.408)	2.33 (1.26)
Median [Min, Max]	2.43 [0.990, 7.56]	1.34 [0.600, 3.13]	1.97 [0.600, 7.56]
Missing	39 (23.2%)	19 (25.3%)	58 (23.9%)
scr_day4_post_terli
Mean (SD)	2.69 (1.24)	1.57 (0.696)	2.38 (1.22)
Median [Min, Max]	2.42 [0.940, 6.97]	1.50 [0.630, 4.47]	2.01 [0.630, 6.97]
Missing	44 (26.2%)	28 (37.3%)	72 (29.6%)
scr_day5_post_terli
Mean (SD)	2.70 (1.31)	1.57 (0.770)	2.38 (1.28)
Median [Min, Max]	2.46 [0.910, 7.07]	1.44 [0.650, 5.42]	1.92 [0.650, 7.07]
Missing	51 (30.4%)	28 (37.3%)	79 (32.5%)
scr_day6_post_terli
Mean (SD)	2.69 (1.22)	1.60 (0.791)	2.39 (1.22)
Median [Min, Max]	2.54 [0.770, 7.22]	1.48 [0.630, 4.98]	2.13 [0.630, 7.22]
Missing	61 (36.3%)	35 (46.7%)	96 (39.5%)
scr_day7_post_terli
Mean (SD)	2.75 (1.31)	1.68 (0.844)	2.51 (1.30)
Median [Min, Max]	2.51 [0.670, 7.25]	1.40 [0.800, 5.13]	2.21 [0.670, 7.25]
Missing	57 (33.9%)	42 (56.0%)	99 (40.7%)
scr_day8_post_terli
Mean (SD)	2.63 (1.32)	1.70 (0.936)	2.41 (1.30)
Median [Min, Max]	2.37 [0.620, 7.58]	1.50 [0.700, 5.69]	2.07 [0.620, 7.58]
Missing	60 (35.7%)	41 (54.7%)	101 (41.6%)
scr_day9_post_terli
Mean (SD)	2.63 (1.40)	1.63 (0.691)	2.38 (1.33)
Median [Min, Max]	2.39 [0.730, 7.60]	1.46 [0.700, 3.62]	2.02 [0.700, 7.60]
Missing	71 (42.3%)	42 (56.0%)	113 (46.5%)
scr_day10_post_terli
Mean (SD)	2.55 (1.56)	1.55 (0.685)	2.29 (1.45)
Median [Min, Max]	2.08 [0.840, 8.80]	1.38 [0.700, 3.48]	1.92 [0.700, 8.80]
Missing	78 (46.4%)	44 (58.7%)	122 (50.2%)
scr_day11_post_terli
Mean (SD)	2.47 (1.42)	1.52 (0.784)	2.22 (1.35)
Median [Min, Max]	2.14 [0.770, 8.50]	1.33 [0.640, 4.01]	1.81 [0.640, 8.50]
Missing	81 (48.2%)	44 (58.7%)	125 (51.4%)
scr_day12_post_terli
Mean (SD)	2.45 (1.40)	1.62 (0.901)	2.22 (1.33)
Median [Min, Max]	2.10 [0.570, 8.00]	1.43 [0.600, 4.29]	1.80 [0.570, 8.00]
Missing	90 (53.6%)	46 (61.3%)	136 (56.0%)
scr_day13_post_terli
Mean (SD)	2.50 (1.48)	1.61 (0.938)	2.26 (1.41)
Median [Min, Max]	2.12 [0.650, 9.60]	1.40 [0.700, 4.48]	1.94 [0.650, 9.60]
Missing	92 (54.8%)	47 (62.7%)	139 (57.2%)
scr_day14_post_terli
Mean (SD)	2.47 (1.36)	1.57 (0.995)	2.25 (1.33)
Median [Min, Max]	2.19 [0.530, 8.40]	1.30 [0.520, 4.17]	1.87 [0.520, 8.40]
Missing	94 (56.0%)	51 (68.0%)	145 (59.7%)
days_to_hrsreversal
Mean (SD)	22.5 (27.1)	13.9 (14.8)	16.8 (20.0)
Median [Min, Max]	16.0 [1.00, 154]	11.0 [3.00, 113]	11.0 [1.00, 154]
Missing	136 (81.0%)	11 (14.7%)	147 (60.5%)
days_to_hrsrecovery
Mean (SD)	19.1 (11.7)	15.3 (18.0)	16.5 (16.3)
Median [Min, Max]	18.5 [6.00, 49.0]	11.0 [3.00, 114]	12.0 [3.00, 114]
Missing	150 (89.3%)	36 (48.0%)	186 (76.5%)
recurrentaki_number
Mean (SD)	1.33 (0.606)	1.19 (0.402)	1.27 (0.522)
Median [Min, Max]	1.00 [1.00, 3.00]	1.00 [1.00, 2.00]	1.00 [1.00, 3.00]
Missing	138 (82.1%)	49 (65.3%)	187 (77.0%)
days_to_recurrentaki
Mean (SD)	24.0 (22.9)	25.2 (23.6)	24.6 (23.0)
Median [Min, Max]	15.5 [8.00, 107]	19.5 [8.00, 128]	16.0 [8.00, 128]
Missing	138 (82.1%)	49 (65.3%)	187 (77.0%)
nadirhospit_scr
Mean (SD)	1.54 (0.777)	1.09 (0.261)	1.40 (0.695)
Median [Min, Max]	1.41 [0.270, 3.93]	1.10 [0.460, 1.57]	1.24 [0.270, 3.93]
Missing	1 (0.6%)	1 (1.3%)	2 (0.8%)
peakhospit_scr
Mean (SD)	4.06 (1.46)	2.82 (1.06)	3.68 (1.46)
Median [Min, Max]	4.00 [1.58, 11.1]	2.55 [1.40, 8.00]	3.39 [1.40, 11.1]
Missing	1 (0.6%)	1 (1.3%)	2 (0.8%)
days_to_peakhospitscr
Mean (SD)	12.1 (14.6)	7.16 (9.54)	10.6 (13.4)
Median [Min, Max]	9.00 [0, 144]	4.00 [0, 48.0]	7.00 [0, 144]
Missing	1 (0.6%)	1 (1.3%)	2 (0.8%)
days_to_rrt
Mean (SD)	12.2 (7.43)	14.9 (9.48)	12.6 (7.71)
Median [Min, Max]	11.0 [1.00, 33.0]	15.5 [0, 28.0]	11.0 [0, 33.0]
Missing	103 (61.3%)	65 (86.7%)	168 (69.1%)

num_hospitalization_course_variables HRS_reversal_new

num_hospitalization_course_variables_formula <- as.formula(paste("~", paste(num_hrs_clinical_course_variables, collapse = "+"),"|HRS_reversal_new"))
table1(num_hospitalization_course_variables_formula,data = final_master)

	0 (N=168)	1 (N=75)	Overall (N=243)
scr_day1_post_terli
Mean (SD)	3.10 (1.36)	1.30 (0.247)	2.53 (1.41)
Median [Min, Max]	2.67 [1.29, 8.84]	1.30 [0.700, 1.80]	2.15 [0.700, 8.84]
Missing	25 (14.9%)	8 (10.7%)	33 (13.6%)
scr_day2_post_terli
Mean (SD)	2.92 (1.32)	1.35 (0.344)	2.44 (1.33)
Median [Min, Max]	2.60 [1.24, 8.73]	1.32 [0.640, 2.44]	2.07 [0.640, 8.73]
Missing	35 (20.8%)	15 (20.0%)	50 (20.6%)
scr_day3_post_terli
Mean (SD)	2.75 (1.28)	1.38 (0.408)	2.33 (1.26)
Median [Min, Max]	2.43 [0.990, 7.56]	1.34 [0.600, 3.13]	1.97 [0.600, 7.56]
Missing	39 (23.2%)	19 (25.3%)	58 (23.9%)
scr_day4_post_terli
Mean (SD)	2.69 (1.24)	1.57 (0.696)	2.38 (1.22)
Median [Min, Max]	2.42 [0.940, 6.97]	1.50 [0.630, 4.47]	2.01 [0.630, 6.97]
Missing	44 (26.2%)	28 (37.3%)	72 (29.6%)
scr_day5_post_terli
Mean (SD)	2.70 (1.31)	1.57 (0.770)	2.38 (1.28)
Median [Min, Max]	2.46 [0.910, 7.07]	1.44 [0.650, 5.42]	1.92 [0.650, 7.07]
Missing	51 (30.4%)	28 (37.3%)	79 (32.5%)
scr_day6_post_terli
Mean (SD)	2.69 (1.22)	1.60 (0.791)	2.39 (1.22)
Median [Min, Max]	2.54 [0.770, 7.22]	1.48 [0.630, 4.98]	2.13 [0.630, 7.22]
Missing	61 (36.3%)	35 (46.7%)	96 (39.5%)
scr_day7_post_terli
Mean (SD)	2.75 (1.31)	1.68 (0.844)	2.51 (1.30)
Median [Min, Max]	2.51 [0.670, 7.25]	1.40 [0.800, 5.13]	2.21 [0.670, 7.25]
Missing	57 (33.9%)	42 (56.0%)	99 (40.7%)
scr_day8_post_terli
Mean (SD)	2.63 (1.32)	1.70 (0.936)	2.41 (1.30)
Median [Min, Max]	2.37 [0.620, 7.58]	1.50 [0.700, 5.69]	2.07 [0.620, 7.58]
Missing	60 (35.7%)	41 (54.7%)	101 (41.6%)
scr_day9_post_terli
Mean (SD)	2.63 (1.40)	1.63 (0.691)	2.38 (1.33)
Median [Min, Max]	2.39 [0.730, 7.60]	1.46 [0.700, 3.62]	2.02 [0.700, 7.60]
Missing	71 (42.3%)	42 (56.0%)	113 (46.5%)
scr_day10_post_terli
Mean (SD)	2.55 (1.56)	1.55 (0.685)	2.29 (1.45)
Median [Min, Max]	2.08 [0.840, 8.80]	1.38 [0.700, 3.48]	1.92 [0.700, 8.80]
Missing	78 (46.4%)	44 (58.7%)	122 (50.2%)
scr_day11_post_terli
Mean (SD)	2.47 (1.42)	1.52 (0.784)	2.22 (1.35)
Median [Min, Max]	2.14 [0.770, 8.50]	1.33 [0.640, 4.01]	1.81 [0.640, 8.50]
Missing	81 (48.2%)	44 (58.7%)	125 (51.4%)
scr_day12_post_terli
Mean (SD)	2.45 (1.40)	1.62 (0.901)	2.22 (1.33)
Median [Min, Max]	2.10 [0.570, 8.00]	1.43 [0.600, 4.29]	1.80 [0.570, 8.00]
Missing	90 (53.6%)	46 (61.3%)	136 (56.0%)
scr_day13_post_terli
Mean (SD)	2.50 (1.48)	1.61 (0.938)	2.26 (1.41)
Median [Min, Max]	2.12 [0.650, 9.60]	1.40 [0.700, 4.48]	1.94 [0.650, 9.60]
Missing	92 (54.8%)	47 (62.7%)	139 (57.2%)
scr_day14_post_terli
Mean (SD)	2.47 (1.36)	1.57 (0.995)	2.25 (1.33)
Median [Min, Max]	2.19 [0.530, 8.40]	1.30 [0.520, 4.17]	1.87 [0.520, 8.40]
Missing	94 (56.0%)	51 (68.0%)	145 (59.7%)
days_to_hrsreversal
Mean (SD)	22.5 (27.1)	13.9 (14.8)	16.8 (20.0)
Median [Min, Max]	16.0 [1.00, 154]	11.0 [3.00, 113]	11.0 [1.00, 154]
Missing	136 (81.0%)	11 (14.7%)	147 (60.5%)
days_to_hrsrecovery
Mean (SD)	19.1 (11.7)	15.3 (18.0)	16.5 (16.3)
Median [Min, Max]	18.5 [6.00, 49.0]	11.0 [3.00, 114]	12.0 [3.00, 114]
Missing	150 (89.3%)	36 (48.0%)	186 (76.5%)
recurrentaki_number
Mean (SD)	1.33 (0.606)	1.19 (0.402)	1.27 (0.522)
Median [Min, Max]	1.00 [1.00, 3.00]	1.00 [1.00, 2.00]	1.00 [1.00, 3.00]
Missing	138 (82.1%)	49 (65.3%)	187 (77.0%)
days_to_recurrentaki
Mean (SD)	24.0 (22.9)	25.2 (23.6)	24.6 (23.0)
Median [Min, Max]	15.5 [8.00, 107]	19.5 [8.00, 128]	16.0 [8.00, 128]
Missing	138 (82.1%)	49 (65.3%)	187 (77.0%)
nadirhospit_scr
Mean (SD)	1.54 (0.777)	1.09 (0.261)	1.40 (0.695)
Median [Min, Max]	1.41 [0.270, 3.93]	1.10 [0.460, 1.57]	1.24 [0.270, 3.93]
Missing	1 (0.6%)	1 (1.3%)	2 (0.8%)
peakhospit_scr
Mean (SD)	4.06 (1.46)	2.82 (1.06)	3.68 (1.46)
Median [Min, Max]	4.00 [1.58, 11.1]	2.55 [1.40, 8.00]	3.39 [1.40, 11.1]
Missing	1 (0.6%)	1 (1.3%)	2 (0.8%)
days_to_peakhospitscr
Mean (SD)	12.1 (14.6)	7.16 (9.54)	10.6 (13.4)
Median [Min, Max]	9.00 [0, 144]	4.00 [0, 48.0]	7.00 [0, 144]
Missing	1 (0.6%)	1 (1.3%)	2 (0.8%)
days_to_rrt
Mean (SD)	12.2 (7.43)	14.9 (9.48)	12.6 (7.71)
Median [Min, Max]	11.0 [1.00, 33.0]	15.5 [0, 28.0]	11.0 [0, 33.0]
Missing	103 (61.3%)	65 (86.7%)	168 (69.1%)

num_followup_variables HRS_reversal_new

num_followup_variables_formula <- as.formula(paste("~", paste(num_followup_variables, collapse = "+"),"|HRS_reversal_new"))
table1(num_followup_variables_formula,data = final_master)

	0 (N=168)	1 (N=75)	Overall (N=243)
dc_aki_recurrence_number
Mean (SD)	1.38 (1.21)	1.39 (0.722)	1.38 (1.03)
Median [Min, Max]	1.00 [0, 7.00]	1.00 [1.00, 3.00]	1.00 [0, 7.00]
Missing	136 (81.0%)	52 (69.3%)	188 (77.4%)
days_to_aki_recurrence
Mean (SD)	42.3 (90.1)	20.3 (17.9)	33.1 (70.1)
Median [Min, Max]	14.0 [1.00, 379]	12.0 [2.00, 58.0]	13.0 [1.00, 379]
Missing	136 (81.0%)	52 (69.3%)	188 (77.4%)
dc_days_lastencounter
Mean (SD)	147 (99.4)	168 (133)	154 (112)
Median [Min, Max]	109 [0, 472]	117 [0, 561]	111 [0, 561]
Missing	83 (49.4%)	30 (40.0%)	113 (46.5%)
dc_days_to_death
Mean (SD)	55.1 (41.6)	66.1 (36.4)	58.5 (40.3)
Median [Min, Max]	90.0 [0, 95.0]	90.0 [0, 90.0]	90.0 [0, 95.0]
Missing	1 (0.6%)	0 (0%)	1 (0.4%)
days_to_lost_to_followup
Mean (SD)	1.10 (8.28)	1.76 (10.7)	1.30 (9.09)
Median [Min, Max]	0 [0, 85.0]	0 [0, 71.0]	0 [0, 85.0]
dc_days_lt
Mean (SD)	152 (187)	232 (274)	176 (217)
Median [Min, Max]	53.5 [2.00, 692]	129 [2.00, 855]	78.5 [2.00, 855]
Missing	136 (81.0%)	61 (81.3%)	197 (81.1%)
dc_scr_90day_postlt_value
Mean (SD)	1.58 (0.586)	1.57 (0.965)	1.58 (0.726)
Median [Min, Max]	1.50 [0.420, 2.93]	1.15 [0.690, 3.92]	1.32 [0.420, 3.92]
Missing	119 (70.8%)	51 (68.0%)	170 (70.0%)
dc_days_to_90dayscr_lt
Mean (SD)	177 (142)	222 (223)	191 (169)
Median [Min, Max]	121 [0, 613]	117 [22.0, 662]	118 [0, 662]
Missing	138 (82.1%)	62 (82.7%)	200 (82.3%)
dc_days_to_neph_followup
Mean (SD)	45.4 (39.7)	40.6 (29.2)	44.3 (37.3)
Median [Min, Max]	36.0 [3.00, 168]	30.5 [15.0, 103]	33.0 [3.00, 168]
Missing	140 (83.3%)	67 (89.3%)	207 (85.2%)
dc_days_to_gihep_followup
Mean (SD)	46.6 (71.6)	31.5 (25.3)	42.1 (61.9)
Median [Min, Max]	22.0 [1.00, 368]	26.0 [5.00, 103]	22.0 [1.00, 368]
Missing	103 (61.3%)	48 (64.0%)	151 (62.1%)
dc_scr30_value
Mean (SD)	2.19 (1.31)	1.45 (0.665)	1.94 (1.18)
Median [Min, Max]	1.82 [0.440, 6.15]	1.21 [0.670, 4.04]	1.69 [0.440, 6.15]
Missing	88 (52.4%)	34 (45.3%)	122 (50.2%)
dc_days_scr30
Mean (SD)	36.8 (15.0)	37.5 (12.8)	37.1 (14.3)
Median [Min, Max]	32.0 [1.00, 111]	32.0 [17.0, 84.0]	32.0 [1.00, 111]
Missing	88 (52.4%)	34 (45.3%)	122 (50.2%)
dc_scr60_value
Mean (SD)	1.74 (0.804)	1.74 (0.977)	1.74 (0.865)
Median [Min, Max]	1.49 [0.480, 4.37]	1.35 [0.700, 4.71]	1.45 [0.480, 4.71]
Missing	99 (58.9%)	37 (49.3%)	136 (56.0%)
dc_days_scr60
Mean (SD)	64.5 (16.7)	69.8 (21.1)	66.4 (18.4)
Median [Min, Max]	62.0 [1.00, 143]	64.0 [17.0, 143]	63.0 [1.00, 143]
Missing	99 (58.9%)	37 (49.3%)	136 (56.0%)
dc_scr90_value
Mean (SD)	1.65 (0.851)	1.70 (0.929)	1.67 (0.874)
Median [Min, Max]	1.50 [0.460, 6.18]	1.24 [0.600, 4.10]	1.49 [0.460, 6.18]
Missing	95 (56.5%)	39 (52.0%)	134 (55.1%)
dc_days_scr91
Mean (SD)	101 (28.8)	125 (54.1)	109 (40.4)
Median [Min, Max]	95.0 [1.00, 255]	99.0 [17.0, 279]	97.0 [1.00, 279]
Missing	95 (56.5%)	39 (52.0%)	134 (55.1%)
days_to_last_encounter_1yr
Mean (SD)	225 (172)	274 (182)	242 (175)
Median [Min, Max]	201 [7.00, 516]	322 [0, 562]	278 [0, 562]
Missing	136 (81.0%)	59 (78.7%)	195 (80.2%)
days_to_death_1yr
Mean (SD)	36.9 (85.2)	53.0 (86.7)	41.4 (85.5)
Median [Min, Max]	1.00 [0, 382]	21.0 [0, 328]	3.00 [0, 382]
Missing	92 (54.8%)	46 (61.3%)	138 (56.8%)
days_lastencounter_1yr
Mean (SD)	110 (166)	75.5 (61.5)	91.0 (115)
Median [Min, Max]	10.0 [0, 387]	66.0 [0, 171]	61.0 [0, 387]
Missing	163 (97.0%)	69 (92.0%)	232 (95.5%)
scr_value_1yr
Mean (SD)	1.61 (0.823)	1.59 (1.28)	1.60 (0.980)
Median [Min, Max]	1.40 [0.570, 4.61]	1.20 [0.400, 6.67]	1.40 [0.400, 6.67]
Missing	122 (72.6%)	54 (72.0%)	176 (72.4%)
days_to_scr_1yr
Mean (SD)	302 (117)	265 (131)	290 (122)
Median [Min, Max]	344 [1.00, 484]	315 [0, 405]	339 [0, 484]
Missing	122 (72.6%)	54 (72.0%)	176 (72.4%)
days_to_lt_1yr
Mean (SD)	49.5 (67.8)	50.1 (49.3)	49.7 (62.9)
Median [Min, Max]	24.0 [0, 360]	30.0 [4.00, 156]	25.5 [0, 360]
Missing	126 (75.0%)	59 (78.7%)	185 (76.1%)

numerical_vars hrs_responders

numerical_vars_formula <- as.formula(paste("~", paste(numerical_vars, collapse = "+"),"|hrs_responders"))
table1(numerical_vars_formula,data = final_master %>% drop_na(hrs_responders))

	0 (N=109)	1 (N=62)	2 (N=72)	Overall (N=243)
age
Mean (SD)	54.9 (11.3)	57.3 (10.8)	57.1 (10.2)	56.2 (10.8)
Median [Min, Max]	57.0 [30.5, 79.1]	59.9 [30.2, 74.3]	57.7 [28.3, 77.1]	57.6 [28.3, 79.1]
scr_admit
Mean (SD)	2.36 (1.19)	2.33 (1.05)	2.36 (1.10)	2.35 (1.13)
Median [Min, Max]	2.18 [0.340, 6.00]	2.30 [0.620, 5.31]	2.20 [0.490, 6.70]	2.23 [0.340, 6.70]
Missing	4 (3.7%)	2 (3.2%)	1 (1.4%)	7 (2.9%)
tbili_admit
Mean (SD)	13.3 (13.1)	9.85 (11.4)	7.30 (8.26)	10.6 (11.6)
Median [Min, Max]	8.10 [0.500, 55.7]	4.80 [0.800, 46.1]	4.00 [0.400, 38.9]	5.00 [0.400, 55.7]
Missing	5 (4.6%)	2 (3.2%)	1 (1.4%)	8 (3.3%)
inr_admit
Mean (SD)	2.05 (0.720)	2.07 (0.803)	1.84 (0.607)	1.99 (0.715)
Median [Min, Max]	1.86 [1.10, 4.60]	1.90 [1.00, 4.90]	1.70 [1.00, 4.20]	1.80 [1.00, 4.90]
Missing	4 (3.7%)	2 (3.2%)	1 (1.4%)	7 (2.9%)
sodium_admit
Mean (SD)	132 (6.43)	131 (6.40)	130 (7.23)	131 (6.69)
Median [Min, Max]	133 [113, 146]	131 [114, 147]	131 [113, 145]	132 [113, 147]
Missing	5 (4.6%)	3 (4.8%)	1 (1.4%)	9 (3.7%)
albumin_admit
Mean (SD)	3.02 (0.657)	3.29 (0.880)	3.10 (0.644)	3.11 (0.721)
Median [Min, Max]	2.95 [1.30, 5.00]	3.20 [1.80, 5.00]	3.00 [1.70, 4.80]	3.00 [1.30, 5.00]
Missing	5 (4.6%)	3 (4.8%)	1 (1.4%)	9 (3.7%)
lactate_admit
Mean (SD)	11.6 (36.4)	3.96 (5.36)	9.78 (25.9)	9.16 (28.5)
Median [Min, Max]	2.30 [0.500, 188]	2.70 [1.40, 27.0]	3.20 [0.900, 147]	2.65 [0.500, 188]
Missing	56 (51.4%)	33 (53.2%)	40 (55.6%)	129 (53.1%)
nsbb_dose_preadmission
Mean (SD)	21.5 (24.7)	38.3 (33.4)	24.7 (22.5)	27.5 (27.3)
Median [Min, Max]	12.5 [2.50, 100]	25.0 [6.25, 100]	16.3 [6.25, 80.0]	16.3 [2.50, 100]
Missing	92 (84.4%)	49 (79.0%)	58 (80.6%)	199 (81.9%)
mido_dose_preadmission
Mean (SD)	23.4 (14.7)	27.2 (16.9)	19.8 (12.7)	23.0 (14.6)
Median [Min, Max]	15.0 [5.00, 65.0]	30.0 [5.00, 60.0]	15.0 [2.50, 45.0]	15.0 [2.50, 65.0]
Missing	74 (67.9%)	45 (72.6%)	46 (63.9%)	165 (67.9%)
baseline_scr
Mean (SD)	1.40 (0.849)	1.31 (0.939)	1.67 (0.842)	1.46 (0.879)
Median [Min, Max]	1.26 [0.310, 5.25]	0.930 [0.480, 5.31]	1.40 [0.580, 4.49]	1.24 [0.310, 5.31]
Missing	0 (0%)	1 (1.6%)	0 (0%)	1 (0.4%)
baseline_scr_days_to_admit
Mean (SD)	46.4 (190)	31.9 (39.8)	29.9 (49.1)	37.8 (132)
Median [Min, Max]	15.0 [0, 1970]	16.5 [0, 242]	14.0 [0, 366]	15.0 [0, 1970]
transfer_aki_days_toadmit
Mean (SD)	6.36 (5.88)	5.76 (4.28)	9.11 (8.66)	6.88 (6.38)
Median [Min, Max]	5.50 [0, 22.0]	5.00 [0, 15.0]	9.00 [0, 28.0]	6.00 [0, 28.0]
Missing	73 (67.0%)	41 (66.1%)	53 (73.6%)	167 (68.7%)
days_admit_to_aki
Mean (SD)	7.64 (37.5)	2.49 (3.53)	2.66 (4.53)	4.86 (25.4)
Median [Min, Max]	0 [0, 366]	1.00 [0, 13.0]	1.00 [0, 20.0]	1.00 [0, 366]
Missing	1 (0.9%)	1 (1.6%)	1 (1.4%)	3 (1.2%)
aki_weight
Mean (SD)	88.9 (23.3)	84.7 (23.6)	85.1 (21.4)	86.7 (22.8)
Median [Min, Max]	83.6 [45.2, 163]	86.1 [51.2, 159]	82.6 [33.7, 145]	83.9 [33.7, 163]
Missing	1 (0.9%)	0 (0%)	0 (0%)	1 (0.4%)
aki_height
Mean (SD)	172 (9.92)	169 (10.5)	168 (22.3)	170 (14.9)
Median [Min, Max]	173 [149, 193]	168 [145, 193]	170 [1.65, 201]	170 [1.65, 201]
Missing	1 (0.9%)	0 (0%)	0 (0%)	1 (0.4%)
aki_hr
Mean (SD)	88.9 (16.2)	92.1 (15.5)	89.3 (18.2)	89.8 (16.7)
Median [Min, Max]	89.0 [55.0, 123]	91.0 [55.0, 128]	91.0 [53.0, 124]	90.0 [53.0, 128]
Missing	3 (2.8%)	3 (4.8%)	2 (2.8%)	8 (3.3%)
aki_sbp
Mean (SD)	103 (16.2)	100 (13.1)	100 (18.8)	102 (16.3)
Median [Min, Max]	100 [76.0, 172]	100 [71.0, 137]	101 [53.0, 150]	100 [53.0, 172]
Missing	3 (2.8%)	3 (4.8%)	2 (2.8%)	8 (3.3%)
aki_dbp
Mean (SD)	58.2 (10.3)	55.9 (13.2)	59.1 (12.9)	57.9 (11.9)
Median [Min, Max]	58.0 [33.0, 96.0]	55.0 [16.0, 85.0]	58.0 [32.0, 98.0]	57.0 [16.0, 98.0]
Missing	3 (2.8%)	3 (4.8%)	2 (2.8%)	8 (3.3%)
aki_map
Mean (SD)	73.1 (10.7)	70.8 (11.4)	72.9 (13.4)	72.5 (11.8)
Median [Min, Max]	72.3 [47.3, 102]	70.3 [47.0, 102]	70.8 [39.0, 114]	71.7 [39.0, 114]
Missing	3 (2.8%)	3 (4.8%)	2 (2.8%)	8 (3.3%)
aki_pao2
Mean (SD)	93.2 (28.0)	89.5 (26.4)	93.4 (27.5)	92.4 (27.4)
Median [Min, Max]	86.0 [54.7, 150]	79.5 [53.0, 145]	86.0 [48.7, 145]	86.0 [48.7, 150]
Missing	28 (25.7%)	20 (32.3%)	20 (27.8%)	68 (28.0%)
fio2_aki
Mean (SD)	8.82 (10.3)	11.9 (16.0)	9.89 (10.8)	9.90 (12.1)
Median [Min, Max]	0.210 [0.210, 21.0]	0.300 [0.210, 100]	0.305 [0.210, 30.0]	0.210 [0.210, 100]
Missing	10 (9.2%)	7 (11.3%)	8 (11.1%)	25 (10.3%)
scr_aki
Mean (SD)	2.38 (1.04)	2.43 (1.01)	2.47 (1.08)	2.42 (1.04)
Median [Min, Max]	2.02 [0.950, 6.00]	2.26 [1.02, 5.31]	2.27 [1.24, 8.00]	2.20 [0.950, 8.00]
bun_aki
Mean (SD)	44.3 (22.7)	45.8 (26.3)	48.6 (19.6)	46.0 (22.8)
Median [Min, Max]	37.0 [2.00, 106]	40.0 [6.00, 146]	45.0 [12.0, 96.0]	40.0 [2.00, 146]
Missing	4 (3.7%)	2 (3.2%)	1 (1.4%)	7 (2.9%)
albumin_aki
Mean (SD)	2.98 (0.695)	3.01 (0.707)	3.07 (0.667)	3.01 (0.688)
Median [Min, Max]	3.00 [1.20, 5.00]	2.90 [1.80, 4.50]	3.00 [1.70, 4.80]	2.95 [1.20, 5.00]
Missing	10 (9.2%)	7 (11.3%)	4 (5.6%)	21 (8.6%)
inr_aki
Mean (SD)	2.00 (0.644)	2.12 (0.823)	1.88 (0.635)	1.99 (0.688)
Median [Min, Max]	1.80 [1.10, 4.40]	1.90 [1.20, 5.10]	1.72 [1.00, 4.20]	1.80 [1.00, 5.10]
Missing	16 (14.7%)	15 (24.2%)	6 (8.3%)	37 (15.2%)
wbc_aki
Mean (SD)	11.9 (11.1)	10.3 (5.46)	9.78 (6.69)	10.9 (8.72)
Median [Min, Max]	9.49 [1.54, 100]	8.86 [1.00, 26.7]	7.40 [1.20, 34.0]	8.40 [1.00, 100]
Missing	9 (8.3%)	6 (9.7%)	2 (2.8%)	17 (7.0%)
plt_aki
Mean (SD)	131 (103)	119 (70.1)	114 (85.7)	123 (90.4)
Median [Min, Max]	96.0 [27.0, 533]	99.0 [23.0, 324]	89.0 [2.00, 456]	94.5 [2.00, 533]
Missing	6 (5.5%)	3 (4.8%)	2 (2.8%)	11 (4.5%)
ecg_qtc
Mean (SD)	455 (75.2)	464 (31.7)	443 (67.0)	453 (64.7)
Median [Min, Max]	460 [0.360, 670]	465 [352, 533]	451 [0.540, 534]	457 [0.360, 670]
Missing	17 (15.6%)	12 (19.4%)	11 (15.3%)	40 (16.5%)
days_to_echo
Mean (SD)	26.8 (49.8)	36.6 (73.0)	18.6 (55.1)	26.8 (58.1)
Median [Min, Max]	7.00 [0, 312]	7.00 [0, 370]	2.00 [0, 240]	5.00 [0, 370]
Missing	30 (27.5%)	17 (27.4%)	19 (26.4%)	66 (27.2%)
echo_ef
Mean (SD)	67.2 (6.18)	64.6 (6.36)	66.3 (5.62)	66.3 (6.12)
Median [Min, Max]	67.5 [55.0, 83.0]	65.0 [55.0, 80.0]	66.0 [51.0, 78.0]	66.0 [51.0, 83.0]
Missing	27 (24.8%)	17 (27.4%)	17 (23.6%)	61 (25.1%)
echo_lateral_e
Mean (SD)	12.1 (3.38)	10.9 (3.44)	10.4 (4.05)	11.2 (3.68)
Median [Min, Max]	11.0 [5.90, 18.4]	12.7 [4.30, 16.0]	11.0 [0.140, 16.0]	11.0 [0.140, 18.4]
Missing	76 (69.7%)	46 (74.2%)	44 (61.1%)	166 (68.3%)
echo_trpeak
Mean (SD)	143 (125)	178 (113)	150 (139)	152 (126)
Median [Min, Max]	170 [1.00, 305]	238 [1.60, 267]	215 [2.00, 343]	225 [1.00, 343]
Missing	82 (75.2%)	51 (82.3%)	54 (75.0%)	187 (77.0%)
echo_gls
Mean (SD)	-2.72 (22.7)	-5.35 (30.3)	1.40 (23.9)	-1.63 (23.4)
Median [Min, Max]	-18.2 [-26.7, 25.5]	-19.5 [-22.5, 40.0]	1.09 [-23.6, 26.1]	-18.4 [-26.7, 40.0]
Missing	95 (87.2%)	58 (93.5%)	62 (86.1%)	215 (88.5%)
echo_earatio
Mean (SD)	1.39 (1.23)	1.03 (0.297)	1.12 (0.399)	1.22 (0.874)
Median [Min, Max]	1.20 [0.400, 9.10]	0.965 [0.690, 2.07]	1.08 [0.510, 2.30]	1.05 [0.400, 9.10]
Missing	62 (56.9%)	40 (64.5%)	36 (50.0%)	138 (56.8%)
echo_rvsp
Mean (SD)	34.1 (11.3)	33.9 (14.3)	35.3 (13.4)	34.4 (12.7)
Median [Min, Max]	35.0 [2.00, 56.0]	32.0 [7.88, 62.0]	31.0 [17.7, 82.0]	33.0 [2.00, 82.0]
Missing	76 (69.7%)	37 (59.7%)	51 (70.8%)	164 (67.5%)
echo_pasp
Mean (SD)	35.4 (17.8)	25.4 (15.9)	36.3 (42.7)	33.3 (25.5)
Median [Min, Max]	31.0 [3.00, 76.0]	29.0 [3.00, 44.0]	24.3 [3.00, 117]	30.0 [3.00, 117]
Missing	98 (89.9%)	57 (91.9%)	66 (91.7%)	221 (90.9%)
echo_lavi
Mean (SD)	33.3 (13.3)	30.5 (10.0)	33.8 (11.8)	32.8 (12.1)
Median [Min, Max]	32.0 [6.32, 74.0]	29.3 [8.00, 56.6]	34.5 [11.8, 68.0]	32.0 [6.32, 74.0]
Missing	44 (40.4%)	30 (48.4%)	28 (38.9%)	102 (42.0%)
echo_tr
Mean (SD)	32.0 (88.5)	55.7 (118)	8.03 (15.8)	29.5 (81.0)
Median [Min, Max]	2.67 [2.26, 339]	3.00 [2.30, 267]	2.51 [1.92, 47.0]	2.64 [1.92, 339]
Missing	92 (84.4%)	57 (91.9%)	64 (88.9%)	213 (87.7%)
totalalbumin_before_terli
Mean (SD)	270 (191)	235 (190)	221 (165)	247 (184)
Median [Min, Max]	225 [12.5, 1230]	200 [12.5, 1010]	200 [0.838, 888]	200 [0.838, 1230]
Missing	7 (6.4%)	10 (16.1%)	8 (11.1%)	25 (10.3%)
albvolume_before_terli
Mean (SD)	1080 (748)	1040 (972)	1160 (1180)	1090 (941)
Median [Min, Max]	900 [50.0, 3900]	800 [100, 5650]	900 [12.5, 8300]	900 [12.5, 8300]
Missing	12 (11.0%)	11 (17.7%)	12 (16.7%)	35 (14.4%)
saline_vol_before_terli
Mean (SD)	1270 (1420)	1240 (1300)	966 (763)	1170 (1220)
Median [Min, Max]	940 [8.00, 5400]	829 [67.5, 5630]	1000 [26.0, 3000]	1000 [8.00, 5630]
Missing	67 (61.5%)	40 (64.5%)	45 (62.5%)	152 (62.6%)
lr_volume_before_terli
Mean (SD)	1870 (1410)	2320 (3450)	1350 (1070)	1860 (2150)
Median [Min, Max]	1470 [500, 7000]	1380 [400, 15300]	1000 [500, 4000]	1250 [400, 15300]
Missing	83 (76.1%)	44 (71.0%)	55 (76.4%)	182 (74.9%)
other_cryst_before_terli
Mean (SD)	2390 (2850)	298 (303)	NA (NA)	1550 (2330)
Median [Min, Max]	1000 [500, 5680]	298 [83.0, 512]	NA [NA, NA]	512 [83.0, 5680]
Missing	106 (97.2%)	60 (96.8%)	72 (100%)	238 (97.9%)
prbc_qaunt_before_terli
Mean (SD)	4.18 (6.53)	2.25 (1.52)	2.47 (1.86)	3.21 (4.68)
Median [Min, Max]	2.00 [1.00, 33.0]	2.00 [0, 5.00]	2.00 [1.00, 8.00]	2.00 [0, 33.0]
Missing	73 (67.0%)	42 (67.7%)	51 (70.8%)	166 (68.3%)
totalvolume_before_terli
Mean (SD)	13700 (36100)	7650 (11900)	6440 (7790)	10000 (25400)
Median [Min, Max]	5130 [0, 284000]	3840 [100, 63500]	4200 [0, 45900]	4650 [0, 284000]
Missing	15 (13.8%)	7 (11.3%)	12 (16.7%)	34 (14.0%)
total_uo_before_terli
Mean (SD)	7780 (18000)	4200 (7180)	4140 (5210)	5820 (13100)
Median [Min, Max]	2200 [0, 116000]	1680 [0, 41400]	2390 [0, 21600]	2100 [0, 116000]
Missing	16 (14.7%)	8 (12.9%)	16 (22.2%)	40 (16.5%)
days_first_mido_before_terli
Mean (SD)	4.15 (10.1)	2.29 (3.62)	20.8 (104)	8.88 (58.4)
Median [Min, Max]	1.00 [0, 84.0]	1.00 [0, 16.0]	1.00 [0, 727]	1.00 [0, 727]
Missing	31 (28.4%)	20 (32.3%)	18 (25.0%)	69 (28.4%)
days_total_mido_before_terli
Mean (SD)	8.90 (16.6)	6.71 (7.53)	7.43 (9.92)	7.92 (12.9)
Median [Min, Max]	6.00 [0, 143]	3.50 [0, 33.0]	4.00 [0, 64.0]	5.00 [0, 143]
Missing	31 (28.4%)	20 (32.3%)	19 (26.4%)	70 (28.8%)
mido_maxdose_before_terli
10	8 (7.3%)	3 (4.8%)	3 (4.2%)	14 (5.8%)
15	16 (14.7%)	3 (4.8%)	3 (4.2%)	22 (9.1%)
20	8 (7.3%)	4 (6.5%)	1 (1.4%)	13 (5.3%)
22.5	1 (0.9%)	0 (0%)	0 (0%)	1 (0.4%)
25	2 (1.8%)	0 (0%)	0 (0%)	2 (0.8%)
30	16 (14.7%)	13 (21.0%)	20 (27.8%)	49 (20.2%)
35	1 (0.9%)	0 (0%)	0 (0%)	1 (0.4%)
40	2 (1.8%)	1 (1.6%)	1 (1.4%)	4 (1.6%)
45	12 (11.0%)	10 (16.1%)	13 (18.1%)	35 (14.4%)
5	4 (3.7%)	1 (1.6%)	1 (1.4%)	6 (2.5%)
50	1 (0.9%)	0 (0%)	0 (0%)	1 (0.4%)
55	2 (1.8%)	1 (1.6%)	1 (1.4%)	4 (1.6%)
60	2 (1.8%)	3 (4.8%)	6 (8.3%)	11 (4.5%)
65	1 (0.9%)	0 (0%)	0 (0%)	1 (0.4%)
7.5	1 (0.9%)	0 (0%)	1 (1.4%)	2 (0.8%)
90	1 (0.9%)	0 (0%)	1 (1.4%)	2 (0.8%)
100	0 (0%)	1 (1.6%)	0 (0%)	1 (0.4%)
70	0 (0%)	1 (1.6%)	0 (0%)	1 (0.4%)
75	0 (0%)	1 (1.6%)	0 (0%)	1 (0.4%)
105	0 (0%)	0 (0%)	1 (1.4%)	1 (0.4%)
2.5	0 (0%)	0 (0%)	2 (2.8%)	2 (0.8%)
Missing	31 (28.4%)	20 (32.3%)	18 (25.0%)	69 (28.4%)
days_first_oct_before_terli
Mean (SD)	9.52 (49.4)	3.86 (6.66)	5.39 (11.0)	6.84 (34.0)
Median [Min, Max]	1.00 [0, 371]	1.00 [0, 30.0]	2.00 [0, 60.0]	1.00 [0, 371]
Missing	53 (48.6%)	27 (43.5%)	41 (56.9%)	121 (49.8%)
days_total_oct_before_terli
Mean (SD)	8.86 (19.4)	5.80 (7.53)	8.13 (11.3)	7.80 (14.8)
Median [Min, Max]	4.50 [0, 143]	3.00 [0, 32.0]	6.00 [0, 64.0]	4.00 [0, 143]
Missing	53 (48.6%)	27 (43.5%)	41 (56.9%)	121 (49.8%)
oct_maxdose_before_terli
Mean (SD)	416 (397)	449 (369)	379 (360)	416 (378)
Median [Min, Max]	300 [50.0, 1250]	300 [50.0, 1200]	300 [50.0, 1200]	300 [50.0, 1250]
Missing	53 (48.6%)	27 (43.5%)	41 (56.9%)	121 (49.8%)
days_first_ne_before_terli
Mean (SD)	2.89 (4.91)	1.00 (1.00)	2.09 (2.66)	2.35 (3.89)
Median [Min, Max]	0.500 [0, 18.0]	1.00 [0, 2.00]	1.00 [0, 7.00]	1.00 [0, 18.0]
Missing	91 (83.5%)	57 (91.9%)	61 (84.7%)	209 (86.0%)
days_total_ne_before_terli
Mean (SD)	9.39 (10.5)	7.40 (8.38)	6.64 (7.90)	8.21 (9.28)
Median [Min, Max]	4.50 [0, 34.0]	3.00 [1.00, 21.0]	4.00 [0, 26.0]	4.00 [0, 34.0]
Missing	91 (83.5%)	57 (91.9%)	61 (84.7%)	209 (86.0%)
days_to_gihep_consult
Mean (SD)	5.60 (37.5)	2.63 (5.66)	3.78 (12.4)	4.32 (26.3)
Median [Min, Max]	1.00 [0, 372]	1.00 [0, 37.0]	1.00 [0, 89.0]	1.00 [0, 372]
Missing	10 (9.2%)	8 (12.9%)	8 (11.1%)	26 (10.7%)
days_to_neph_consult
Mean (SD)	11.3 (52.0)	3.66 (5.26)	3.71 (5.32)	7.16 (35.5)
Median [Min, Max]	2.00 [0, 372]	2.00 [0, 30.0]	1.00 [0, 25.0]	2.00 [0, 372]
Missing	9 (8.3%)	6 (9.7%)	10 (13.9%)	25 (10.3%)
days_to_pall_consult
Mean (SD)	12.5 (15.0)	11.7 (14.5)	21.6 (39.8)	14.2 (22.1)
Median [Min, Max]	10.5 [0, 93.0]	6.50 [0, 55.0]	9.50 [0, 162]	9.00 [0, 162]
Missing	61 (56.0%)	46 (74.2%)	56 (77.8%)	163 (67.1%)
days_ua_hrs
Mean (SD)	4.43 (14.5)	3.45 (5.55)	3.54 (8.86)	3.92 (11.2)
Median [Min, Max]	1.00 [0, 140]	1.00 [0, 30.0]	1.00 [0, 58.0]	1.00 [0, 140]
Missing	6 (5.5%)	6 (9.7%)	7 (9.7%)	19 (7.8%)
days_ua_na_hrs
Mean (SD)	5.33 (15.2)	3.45 (5.69)	3.57 (8.62)	4.33 (11.5)
Median [Min, Max]	2.00 [0, 140]	1.00 [0, 30.0]	1.00 [0, 58.0]	1.00 [0, 140]
Missing	16 (14.7%)	7 (11.3%)	11 (15.3%)	34 (14.0%)
ua_na_value_hrs
Mean (SD)	18.4 (12.6)	23.5 (21.9)	18.4 (17.8)	19.7 (17.0)
Median [Min, Max]	19.0 [5.00, 81.0]	19.0 [9.00, 140]	19.0 [9.00, 110]	19.0 [5.00, 140]
Missing	16 (14.7%)	7 (11.3%)	11 (15.3%)	34 (14.0%)
days_ua_cr_hrs
Mean (SD)	6.48 (16.8)	4.68 (8.46)	5.30 (16.2)	5.68 (14.9)
Median [Min, Max]	2.00 [0, 143]	1.00 [0, 42.0]	1.00 [0, 108]	1.00 [0, 143]
Missing	30 (27.5%)	18 (29.0%)	22 (30.6%)	70 (28.8%)
ua_cr_value_hrs
Mean (SD)	141 (68.8)	132 (61.1)	145 (71.9)	140 (67.7)
Median [Min, Max]	132 [31.2, 418]	124 [27.4, 309]	134 [31.2, 378]	128 [27.4, 418]
Missing	30 (27.5%)	18 (29.0%)	22 (30.6%)	70 (28.8%)
days_ua_urea_hrs
Mean (SD)	6.69 (9.22)	3.72 (4.68)	2.67 (3.62)	4.52 (6.83)
Median [Min, Max]	2.00 [0, 35.0]	1.00 [0, 15.0]	1.00 [0, 13.0]	1.00 [0, 35.0]
Missing	74 (67.9%)	44 (71.0%)	39 (54.2%)	157 (64.6%)
ua_urea_value_hrs
Mean (SD)	533 (235)	487 (207)	537 (216)	525 (220)
Median [Min, Max]	532 [96.0, 1180]	485 [2.80, 891]	518 [82.0, 923]	513 [2.80, 1180]
Missing	74 (67.9%)	44 (71.0%)	39 (54.2%)	157 (64.6%)
feurea_hrs
Mean (SD)	30.5 (23.0)	18.9 (7.43)	20.5 (11.0)	24.2 (17.1)
Median [Min, Max]	29.0 [6.70, 124]	17.5 [1.93, 36.2]	19.2 [4.32, 52.6]	21.2 [1.93, 124]
Missing	78 (71.6%)	46 (74.2%)	42 (58.3%)	166 (68.3%)
ua_rbc_hrs
Mean (SD)	20.3 (38.6)	7.02 (16.1)	16.1 (30.4)	15.8 (32.4)
Median [Min, Max]	3.00 [0, 182]	2.00 [0, 101]	4.00 [0, 151]	2.00 [0, 182]
Missing	22 (20.2%)	17 (27.4%)	16 (22.2%)	55 (22.6%)
uaprotein_hrs
Mean (SD)	78.2 (135)	36.1 (63.7)	48.5 (149)	58.6 (126)
Median [Min, Max]	20.0 [0, 521]	0.550 [0, 250]	0.385 [0, 730]	2.00 [0, 730]
Missing	55 (50.5%)	31 (50.0%)	36 (50.0%)	122 (50.2%)
temp_terli_day0
Mean (SD)	36.5 (0.436)	37.6 (7.75)	36.6 (0.520)	36.8 (3.94)
Median [Min, Max]	36.6 [34.1, 37.4]	36.6 [34.3, 97.5]	36.6 [34.7, 38.2]	36.6 [34.1, 97.5]
hr_terli_day0
Mean (SD)	79.5 (16.9)	78.7 (14.6)	78.4 (17.3)	79.0 (16.4)
Median [Min, Max]	81.0 [39.0, 124]	79.0 [48.0, 117]	77.5 [45.0, 124]	80.0 [39.0, 124]
pao2_terli_day0
Mean (SD)	105 (63.0)	98.2 (26.7)	99.7 (27.4)	102 (46.9)
Median [Min, Max]	88.3 [49.0, 616]	90.5 [56.0, 150]	86.0 [60.0, 150]	88.0 [49.0, 616]
Missing	25 (22.9%)	14 (22.6%)	20 (27.8%)	59 (24.3%)
fio2_terli_day0
Mean (SD)	0.217 (0.0483)	0.228 (0.0768)	0.223 (0.0678)	0.222 (0.0623)
Median [Min, Max]	0.210 [0.0197, 0.600]	0.210 [0.210, 0.700]	0.210 [0.210, 0.730]	0.210 [0.0197, 0.730]
Missing	5 (4.6%)	4 (6.5%)	6 (8.3%)	15 (6.2%)
sbp_terli_day0_time0
Mean (SD)	108 (15.0)	109 (15.6)	109 (13.6)	108 (14.7)
Median [Min, Max]	106 [80.0, 157]	105 [85.0, 157]	108 [81.0, 138]	106 [80.0, 157]
Missing	13 (11.9%)	4 (6.5%)	9 (12.5%)	26 (10.7%)
map_terli_day0_time0
Mean (SD)	67.0 (26.9)	72.4 (19.6)	66.5 (26.8)	68.2 (25.3)
Median [Min, Max]	73.3 [0, 138]	73.3 [0, 115]	73.0 [0, 100]	73.2 [0, 138]
Missing	0 (0%)	1 (1.6%)	0 (0%)	1 (0.4%)
chloride_terli_day0
Mean (SD)	99.9 (7.30)	101 (6.27)	101 (7.04)	100 (6.97)
Median [Min, Max]	100 [80.0, 119]	102 [84.0, 118]	102 [80.0, 117]	101 [80.0, 119]
bicarb_terli_day0
Mean (SD)	18.5 (4.11)	18.3 (3.78)	19.7 (3.80)	18.8 (3.96)
Median [Min, Max]	19.0 [9.00, 29.0]	18.0 [7.00, 26.0]	19.5 [13.0, 32.0]	19.0 [7.00, 32.0]
Missing	2 (1.8%)	1 (1.6%)	2 (2.8%)	5 (2.1%)
scr_terli_day0
Mean (SD)	3.11 (1.02)	3.06 (0.943)	2.60 (0.828)	2.95 (0.968)
Median [Min, Max]	2.89 [1.23, 5.79]	2.90 [1.54, 5.18]	2.50 [1.28, 5.02]	2.79 [1.23, 5.79]
bun_terli_day0
Mean (SD)	57.0 (24.5)	56.4 (25.0)	56.2 (22.6)	56.6 (24.0)
Median [Min, Max]	54.0 [10.0, 132]	53.0 [5.00, 123]	54.0 [18.0, 145]	54.0 [5.00, 145]
Missing	1 (0.9%)	1 (1.6%)	0 (0%)	2 (0.8%)
ast_terli_day0
Mean (SD)	77.1 (62.6)	67.6 (65.3)	55.3 (43.0)	68.4 (58.9)
Median [Min, Max]	58.5 [1.22, 405]	44.0 [13.0, 402]	45.0 [15.0, 254]	51.5 [1.22, 405]
Missing	5 (4.6%)	3 (4.8%)	7 (9.7%)	15 (6.2%)
alt_terli_day0
Mean (SD)	34.4 (31.7)	31.1 (28.9)	24.6 (18.5)	30.7 (28.0)
Median [Min, Max]	24.0 [4.00, 209]	20.0 [5.00, 169]	21.0 [5.00, 112]	23.0 [4.00, 209]
Missing	5 (4.6%)	3 (4.8%)	7 (9.7%)	15 (6.2%)
bili_terli_day0
Mean (SD)	14.6 (14.7)	11.0 (11.8)	7.31 (8.39)	11.6 (12.7)
Median [Min, Max]	9.60 [0.300, 57.3]	6.10 [0.700, 41.2]	4.05 [1.00, 38.3]	5.60 [0.300, 57.3]
Missing	6 (5.5%)	3 (4.8%)	6 (8.3%)	15 (6.2%)
alb_terli_day0
Mean (SD)	3.48 (0.526)	3.50 (0.563)	3.59 (0.572)	3.52 (0.550)
Median [Min, Max]	3.50 [2.20, 4.80]	3.50 [2.10, 4.80]	3.60 [2.10, 5.00]	3.50 [2.10, 5.00]
Missing	7 (6.4%)	5 (8.1%)	3 (4.2%)	15 (6.2%)
inr_terli_day0
Mean (SD)	2.25 (0.886)	2.23 (0.645)	2.13 (0.705)	2.21 (0.777)
Median [Min, Max]	2.10 [1.00, 6.90]	2.20 [1.30, 3.54]	2.00 [1.20, 4.10]	2.10 [1.00, 6.90]
Missing	20 (18.3%)	9 (14.5%)	19 (26.4%)	48 (19.8%)
wbc_terli_day0
Mean (SD)	10.2 (7.21)	9.05 (5.13)	7.87 (4.89)	9.22 (6.14)
Median [Min, Max]	8.40 [1.50, 41.3]	8.06 [2.30, 26.4]	6.44 [2.80, 26.9]	7.30 [1.50, 41.3]
Missing	5 (4.6%)	1 (1.6%)	3 (4.2%)	9 (3.7%)
hgb_terli_day0
Mean (SD)	8.21 (1.25)	8.52 (1.53)	8.41 (1.32)	8.35 (1.35)
Median [Min, Max]	8.00 [6.00, 12.7]	8.20 [5.30, 12.9]	8.00 [6.30, 11.9]	8.00 [5.30, 12.9]
Missing	2 (1.8%)	0 (0%)	2 (2.8%)	4 (1.6%)
Discont_Day
Mean (SD)	3.04 (2.36)	4.74 (3.28)	4.90 (3.12)	4.02 (2.98)
Median [Min, Max]	2.00 [1.00, 13.0]	4.00 [1.00, 13.0]	4.00 [1.00, 13.0]	3.00 [1.00, 13.0]
na_terli_day0
Mean (SD)	132 (5.69)	133 (5.78)	133 (5.48)	132 (5.63)
Median [Min, Max]	133 [120, 144]	132 [120, 146]	133 [119, 147]	133 [119, 147]
days_to_terli_initiation_day0
Mean (SD)	8.50 (14.7)	7.08 (7.84)	7.08 (8.93)	7.72 (11.6)
Median [Min, Max]	5.00 [0, 143]	4.50 [1.00, 40.0]	4.00 [0, 64.0]	5.00 [0, 143]
clif_c_score
Mean (SD)	43.2 (9.00)	42.8 (7.83)	39.6 (7.15)	42.0 (8.32)
Median [Min, Max]	42.6 [19.6, 62.4]	41.8 [27.3, 58.9]	38.9 [24.6, 56.0]	41.4 [19.6, 62.4]
Missing	5 (4.6%)	1 (1.6%)	3 (4.2%)	9 (3.7%)
admit_meld
Mean (SD)	28.3 (8.62)	27.4 (7.15)	25.5 (6.62)	27.2 (7.75)
Median [Min, Max]	28.0 [8.00, 48.0]	28.0 [13.0, 39.0]	26.0 [11.0, 40.0]	27.0 [8.00, 48.0]
Missing	5 (4.6%)	2 (3.2%)	1 (1.4%)	8 (3.3%)
admit_meld_na
Mean (SD)	30.3 (7.35)	29.7 (6.20)	29.0 (5.19)	29.7 (6.47)
Median [Min, Max]	30.0 [12.0, 46.0]	30.0 [16.0, 39.0]	29.5 [17.0, 40.0]	30.0 [12.0, 46.0]
Missing	6 (5.5%)	3 (4.8%)	2 (2.8%)	11 (4.5%)
admit_meld_3
Mean (SD)	31.8 (8.48)	31.0 (6.94)	30.1 (6.01)	31.1 (7.44)
Median [Min, Max]	32.0 [5.00, 50.0]	31.0 [16.0, 42.0]	30.0 [14.0, 42.0]	31.0 [5.00, 50.0]
admit_meld_3_raw
Mean (SD)	31.9 (8.68)	30.9 (7.18)	30.1 (6.06)	31.1 (7.60)
Median [Min, Max]	32.0 [5.00, 50.0]	31.0 [16.0, 42.0]	30.0 [14.0, 42.0]	31.0 [5.00, 50.0]
Missing	5 (4.6%)	4 (6.5%)	1 (1.4%)	10 (4.1%)
day0_meld
Mean (SD)	32.6 (7.96)	31.7 (6.54)	29.1 (6.93)	31.5 (7.44)
Median [Min, Max]	33.0 [16.0, 51.0]	33.0 [17.0, 47.0]	29.0 [17.0, 44.0]	32.0 [16.0, 51.0]
Missing	21 (19.3%)	10 (16.1%)	22 (30.6%)	53 (21.8%)
day0_meld_na
Mean (SD)	33.7 (7.00)	32.8 (5.95)	31.0 (6.22)	32.7 (6.59)
Median [Min, Max]	34.0 [16.0, 50.0]	34.0 [19.0, 46.0]	31.0 [18.0, 44.0]	34.0 [16.0, 50.0]
Missing	21 (19.3%)	10 (16.1%)	22 (30.6%)	53 (21.8%)
day0_meld_3
Mean (SD)	35.6 (8.14)	34.4 (7.72)	32.4 (7.02)	34.4 (7.81)
Median [Min, Max]	37.0 [13.0, 53.0]	35.0 [10.0, 49.0]	32.0 [17.0, 45.0]	35.0 [10.0, 53.0]
Missing	23 (21.1%)	12 (19.4%)	22 (30.6%)	57 (23.5%)
time_to_transplant
Mean (SD)	37.3 (46.1)	38.4 (50.1)	48.7 (54.1)	41.0 (49.2)
Median [Min, Max]	19.0 [4.00, 199]	16.0 [3.00, 167]	26.0 [2.00, 186]	20.0 [2.00, 199]
Missing	78 (71.6%)	44 (71.0%)	51 (70.8%)	173 (71.2%)
time_to_death_status
0	55 (50.5%)	38 (61.3%)	47 (65.3%)	140 (57.6%)
1	54 (49.5%)	24 (38.7%)	25 (34.7%)	103 (42.4%)
cystatinc_admit
Mean (SD)	2.93 (0.929)	2.99 (0.570)	2.93 (0.701)	2.94 (0.777)
Median [Min, Max]	2.95 [1.16, 4.16]	2.83 [2.25, 3.90]	2.85 [1.80, 4.20]	2.89 [1.16, 4.20]
Missing	93 (85.3%)	55 (88.7%)	62 (86.1%)	210 (86.4%)
cystatinc_aki
Mean (SD)	2.74 (0.969)	2.53 (1.18)	3.02 (0.804)	2.79 (0.914)
Median [Min, Max]	2.62 [1.23, 4.16]	2.83 [1.23, 3.54]	2.87 [2.19, 4.10]	2.71 [1.23, 4.16]
Missing	99 (90.8%)	59 (95.2%)	66 (91.7%)	224 (92.2%)
cystatinc_terli_day0
Mean (SD)	3.85 (1.07)	2.49 (1.10)	2.63 (0.653)	2.95 (1.10)
Median [Min, Max]	3.71 [2.40, 6.10]	2.61 [0.239, 3.90]	2.87 [1.52, 3.57]	2.91 [0.239, 6.10]
Missing	101 (92.7%)	53 (85.5%)	63 (87.5%)	217 (89.3%)
urine_pc
Mean (SD)	0.686 (1.14)	0.299 (0.508)	0.457 (1.43)	0.517 (1.12)
Median [Min, Max]	0.163 [0, 5.95]	0.0143 [0, 2.18]	0.00479 [0, 7.07]	0.0736 [0, 7.07]
Missing	63 (57.8%)	35 (56.5%)	40 (55.6%)	138 (56.8%)
fena
Mean (SD)	0.393 (0.762)	0.808 (2.68)	0.389 (0.808)	0.501 (1.53)
Median [Min, Max]	0.213 [0.0228, 5.64]	0.215 [0.0517, 17.2]	0.160 [0.0498, 5.07]	0.211 [0.0228, 17.2]
Missing	39 (35.8%)	20 (32.3%)	24 (33.3%)	83 (34.2%)
fena_hrs
Mean (SD)	0.435 (0.743)	0.779 (2.18)	0.362 (0.702)	0.502 (1.28)
Median [Min, Max]	0.232 [0.0327, 5.60]	0.241 [0.0949, 14.0]	0.159 [0.0469, 4.48]	0.220 [0.0327, 14.0]
Missing	35 (32.1%)	19 (30.6%)	23 (31.9%)	77 (31.7%)
time_to_death_90days
Mean (SD)	51.0 (37.2)	64.2 (33.9)	70.0 (29.1)	60.0 (35.0)
Median [Min, Max]	35.0 [1.00, 90.0]	90.0 [3.00, 90.0]	90.0 [4.00, 90.0]	90.0 [1.00, 90.0]
total_albumin
Mean (SD)	94.2 (103)	75.2 (89.8)	94.7 (110)	89.5 (102)
Median [Min, Max]	75.0 [0, 500]	50.0 [0, 350]	68.8 [0, 700]	62.5 [0, 700]

num_hrs_clinical_course_variables hrs_responders

num_hrs_clinical_course_variables_formula <- as.formula(paste("~", paste(num_hrs_clinical_course_variables, collapse = "+"),"|hrs_responders"))
table1(num_hrs_clinical_course_variables_formula,data = final_master%>% drop_na(hrs_responders))

	0 (N=109)	1 (N=62)	2 (N=72)	Overall (N=243)
scr_day1_post_terli
Mean (SD)	3.43 (1.47)	2.07 (0.846)	1.50 (0.578)	2.53 (1.41)
Median [Min, Max]	3.12 [1.30, 8.84]	1.78 [1.01, 4.34]	1.35 [0.700, 4.14]	2.15 [0.700, 8.84]
Missing	14 (12.8%)	6 (9.7%)	13 (18.1%)	33 (13.6%)
scr_day2_post_terli
Mean (SD)	3.20 (1.44)	2.11 (0.860)	1.45 (0.450)	2.44 (1.33)
Median [Min, Max]	2.93 [1.25, 8.73]	1.85 [1.05, 4.06]	1.40 [0.640, 3.04]	2.07 [0.640, 8.73]
Missing	19 (17.4%)	12 (19.4%)	19 (26.4%)	50 (20.6%)
scr_day3_post_terli
Mean (SD)	2.93 (1.41)	2.15 (0.902)	1.50 (0.534)	2.33 (1.26)
Median [Min, Max]	2.57 [0.990, 7.56]	1.95 [0.890, 4.12]	1.42 [0.600, 3.44]	1.97 [0.600, 7.56]
Missing	22 (20.2%)	15 (24.2%)	21 (29.2%)	58 (23.9%)
scr_day4_post_terli
Mean (SD)	2.80 (1.38)	2.35 (0.955)	1.58 (0.573)	2.38 (1.22)
Median [Min, Max]	2.40 [0.980, 6.97]	2.10 [1.15, 4.47]	1.50 [0.630, 3.08]	2.01 [0.630, 6.97]
Missing	24 (22.0%)	19 (30.6%)	29 (40.3%)	72 (29.6%)
scr_day5_post_terli
Mean (SD)	2.80 (1.47)	2.26 (0.970)	1.72 (0.775)	2.38 (1.28)
Median [Min, Max]	2.41 [0.910, 7.07]	1.99 [1.20, 5.42]	1.53 [0.650, 4.28]	1.92 [0.650, 7.07]
Missing	29 (26.6%)	22 (35.5%)	28 (38.9%)	79 (32.5%)
scr_day6_post_terli
Mean (SD)	2.69 (1.25)	2.52 (1.28)	1.74 (0.814)	2.39 (1.22)
Median [Min, Max]	2.51 [0.770, 7.22]	2.16 [1.10, 6.47]	1.54 [0.630, 4.00]	2.13 [0.630, 7.22]
Missing	36 (33.0%)	28 (45.2%)	32 (44.4%)	96 (39.5%)
scr_day7_post_terli
Mean (SD)	2.78 (1.39)	2.47 (1.28)	1.94 (0.909)	2.51 (1.30)
Median [Min, Max]	2.44 [0.670, 7.25]	1.92 [0.960, 5.72]	1.88 [0.800, 4.32]	2.21 [0.670, 7.25]
Missing	35 (32.1%)	26 (41.9%)	38 (52.8%)	99 (40.7%)
scr_day8_post_terli
Mean (SD)	2.61 (1.44)	2.55 (1.24)	1.85 (0.825)	2.41 (1.30)
Median [Min, Max]	2.26 [0.620, 7.58]	2.19 [1.10, 5.69]	1.68 [0.700, 3.55]	2.07 [0.620, 7.58]
Missing	37 (33.9%)	28 (45.2%)	36 (50.0%)	101 (41.6%)
scr_day9_post_terli
Mean (SD)	2.66 (1.54)	2.41 (1.13)	1.79 (0.785)	2.38 (1.33)
Median [Min, Max]	2.34 [0.730, 7.60]	2.03 [0.980, 5.41]	1.59 [0.700, 3.62]	2.02 [0.700, 7.60]
Missing	44 (40.4%)	29 (46.8%)	40 (55.6%)	113 (46.5%)
scr_day10_post_terli
Mean (SD)	2.61 (1.80)	2.13 (1.09)	1.88 (0.808)	2.29 (1.45)
Median [Min, Max]	2.01 [0.840, 8.80]	1.89 [0.950, 5.06]	1.68 [0.700, 3.48]	1.92 [0.700, 8.80]
Missing	51 (46.8%)	31 (50.0%)	40 (55.6%)	122 (50.2%)
scr_day11_post_terli
Mean (SD)	2.55 (1.54)	1.94 (1.13)	1.86 (0.958)	2.22 (1.35)
Median [Min, Max]	2.05 [0.770, 8.50]	1.61 [0.640, 5.04]	1.66 [0.690, 4.01]	1.81 [0.640, 8.50]
Missing	50 (45.9%)	33 (53.2%)	42 (58.3%)	125 (51.4%)
scr_day12_post_terli
Mean (SD)	2.48 (1.48)	1.95 (1.08)	2.03 (1.23)	2.22 (1.33)
Median [Min, Max]	2.07 [0.570, 8.00]	1.62 [0.880, 5.21]	1.84 [0.600, 5.77]	1.80 [0.570, 8.00]
Missing	58 (53.2%)	34 (54.8%)	44 (61.1%)	136 (56.0%)
scr_day13_post_terli
Mean (SD)	2.45 (1.53)	2.04 (1.18)	2.15 (1.41)	2.26 (1.41)
Median [Min, Max]	2.16 [0.650, 9.60]	1.64 [0.950, 5.66]	1.92 [0.700, 5.76]	1.94 [0.650, 9.60]
Missing	60 (55.0%)	34 (54.8%)	45 (62.5%)	139 (57.2%)
scr_day14_post_terli
Mean (SD)	2.49 (1.43)	2.00 (1.05)	2.00 (1.32)	2.25 (1.33)
Median [Min, Max]	2.27 [0.530, 8.40]	1.54 [0.840, 4.77]	1.72 [0.520, 5.86]	1.87 [0.520, 8.40]
Missing	59 (54.1%)	39 (62.9%)	47 (65.3%)	145 (59.7%)
days_to_hrsreversal
Mean (SD)	27.8 (32.7)	13.9 (9.18)	13.9 (16.4)	16.8 (20.0)
Median [Min, Max]	20.5 [1.00, 154]	12.0 [3.00, 39.0]	11.0 [3.00, 113]	11.0 [1.00, 154]
Missing	89 (81.7%)	33 (53.2%)	25 (34.7%)	147 (60.5%)
days_to_hrsrecovery
Mean (SD)	28.4 (12.3)	16.4 (9.98)	14.2 (18.3)	16.5 (16.3)
Median [Min, Max]	27.0 [11.0, 49.0]	14.0 [3.00, 39.0]	10.0 [3.00, 114]	12.0 [3.00, 114]
Missing	102 (93.6%)	47 (75.8%)	37 (51.4%)	186 (76.5%)
recurrentaki_number
Mean (SD)	1.37 (0.684)	1.08 (0.277)	1.29 (0.464)	1.27 (0.522)
Median [Min, Max]	1.00 [1.00, 3.00]	1.00 [1.00, 2.00]	1.00 [1.00, 2.00]	1.00 [1.00, 3.00]
Missing	90 (82.6%)	49 (79.0%)	48 (66.7%)	187 (77.0%)
days_to_recurrentaki
Mean (SD)	27.6 (24.3)	25.2 (31.7)	21.8 (16.3)	24.6 (23.0)
Median [Min, Max]	16.0 [10.0, 107]	16.0 [11.0, 128]	19.0 [8.00, 89.0]	16.0 [8.00, 128]
Missing	90 (82.6%)	49 (79.0%)	48 (66.7%)	187 (77.0%)
nadirhospit_scr
Mean (SD)	1.50 (0.827)	1.40 (0.645)	1.27 (0.461)	1.40 (0.695)
Median [Min, Max]	1.29 [0.270, 3.93]	1.21 [0.470, 3.86]	1.25 [0.460, 2.99]	1.24 [0.270, 3.93]
Missing	0 (0%)	2 (3.2%)	0 (0%)	2 (0.8%)
peakhospit_scr
Mean (SD)	4.25 (1.59)	3.48 (1.21)	2.99 (1.07)	3.68 (1.46)
Median [Min, Max]	4.09 [1.58, 11.1]	3.19 [1.72, 6.69]	2.80 [1.40, 8.00]	3.39 [1.40, 11.1]
Missing	0 (0%)	2 (3.2%)	0 (0%)	2 (0.8%)
days_to_peakhospitscr
Mean (SD)	14.3 (16.6)	8.90 (10.3)	6.43 (7.80)	10.6 (13.4)
Median [Min, Max]	11.0 [0, 144]	4.50 [0, 51.0]	3.00 [0, 44.0]	7.00 [0, 144]
Missing	0 (0%)	2 (3.2%)	0 (0%)	2 (0.8%)
days_to_rrt
Mean (SD)	11.9 (6.74)	14.1 (9.38)	13.7 (9.55)	12.6 (7.71)
Median [Min, Max]	11.0 [1.00, 26.0]	11.0 [2.00, 33.0]	12.0 [0, 30.0]	11.0 [0, 33.0]
Missing	60 (55.0%)	47 (75.8%)	61 (84.7%)	168 (69.1%)

num_hospitalization_course_variables hrs_responders

num_hospitalization_course_variables_formula <- as.formula(paste("~", paste(num_hrs_clinical_course_variables, collapse = "+"),"|hrs_responders"))
table1(num_hospitalization_course_variables_formula,data = final_master%>% drop_na(hrs_responders))

	0 (N=109)	1 (N=62)	2 (N=72)	Overall (N=243)
scr_day1_post_terli
Mean (SD)	3.43 (1.47)	2.07 (0.846)	1.50 (0.578)	2.53 (1.41)
Median [Min, Max]	3.12 [1.30, 8.84]	1.78 [1.01, 4.34]	1.35 [0.700, 4.14]	2.15 [0.700, 8.84]
Missing	14 (12.8%)	6 (9.7%)	13 (18.1%)	33 (13.6%)
scr_day2_post_terli
Mean (SD)	3.20 (1.44)	2.11 (0.860)	1.45 (0.450)	2.44 (1.33)
Median [Min, Max]	2.93 [1.25, 8.73]	1.85 [1.05, 4.06]	1.40 [0.640, 3.04]	2.07 [0.640, 8.73]
Missing	19 (17.4%)	12 (19.4%)	19 (26.4%)	50 (20.6%)
scr_day3_post_terli
Mean (SD)	2.93 (1.41)	2.15 (0.902)	1.50 (0.534)	2.33 (1.26)
Median [Min, Max]	2.57 [0.990, 7.56]	1.95 [0.890, 4.12]	1.42 [0.600, 3.44]	1.97 [0.600, 7.56]
Missing	22 (20.2%)	15 (24.2%)	21 (29.2%)	58 (23.9%)
scr_day4_post_terli
Mean (SD)	2.80 (1.38)	2.35 (0.955)	1.58 (0.573)	2.38 (1.22)
Median [Min, Max]	2.40 [0.980, 6.97]	2.10 [1.15, 4.47]	1.50 [0.630, 3.08]	2.01 [0.630, 6.97]
Missing	24 (22.0%)	19 (30.6%)	29 (40.3%)	72 (29.6%)
scr_day5_post_terli
Mean (SD)	2.80 (1.47)	2.26 (0.970)	1.72 (0.775)	2.38 (1.28)
Median [Min, Max]	2.41 [0.910, 7.07]	1.99 [1.20, 5.42]	1.53 [0.650, 4.28]	1.92 [0.650, 7.07]
Missing	29 (26.6%)	22 (35.5%)	28 (38.9%)	79 (32.5%)
scr_day6_post_terli
Mean (SD)	2.69 (1.25)	2.52 (1.28)	1.74 (0.814)	2.39 (1.22)
Median [Min, Max]	2.51 [0.770, 7.22]	2.16 [1.10, 6.47]	1.54 [0.630, 4.00]	2.13 [0.630, 7.22]
Missing	36 (33.0%)	28 (45.2%)	32 (44.4%)	96 (39.5%)
scr_day7_post_terli
Mean (SD)	2.78 (1.39)	2.47 (1.28)	1.94 (0.909)	2.51 (1.30)
Median [Min, Max]	2.44 [0.670, 7.25]	1.92 [0.960, 5.72]	1.88 [0.800, 4.32]	2.21 [0.670, 7.25]
Missing	35 (32.1%)	26 (41.9%)	38 (52.8%)	99 (40.7%)
scr_day8_post_terli
Mean (SD)	2.61 (1.44)	2.55 (1.24)	1.85 (0.825)	2.41 (1.30)
Median [Min, Max]	2.26 [0.620, 7.58]	2.19 [1.10, 5.69]	1.68 [0.700, 3.55]	2.07 [0.620, 7.58]
Missing	37 (33.9%)	28 (45.2%)	36 (50.0%)	101 (41.6%)
scr_day9_post_terli
Mean (SD)	2.66 (1.54)	2.41 (1.13)	1.79 (0.785)	2.38 (1.33)
Median [Min, Max]	2.34 [0.730, 7.60]	2.03 [0.980, 5.41]	1.59 [0.700, 3.62]	2.02 [0.700, 7.60]
Missing	44 (40.4%)	29 (46.8%)	40 (55.6%)	113 (46.5%)
scr_day10_post_terli
Mean (SD)	2.61 (1.80)	2.13 (1.09)	1.88 (0.808)	2.29 (1.45)
Median [Min, Max]	2.01 [0.840, 8.80]	1.89 [0.950, 5.06]	1.68 [0.700, 3.48]	1.92 [0.700, 8.80]
Missing	51 (46.8%)	31 (50.0%)	40 (55.6%)	122 (50.2%)
scr_day11_post_terli
Mean (SD)	2.55 (1.54)	1.94 (1.13)	1.86 (0.958)	2.22 (1.35)
Median [Min, Max]	2.05 [0.770, 8.50]	1.61 [0.640, 5.04]	1.66 [0.690, 4.01]	1.81 [0.640, 8.50]
Missing	50 (45.9%)	33 (53.2%)	42 (58.3%)	125 (51.4%)
scr_day12_post_terli
Mean (SD)	2.48 (1.48)	1.95 (1.08)	2.03 (1.23)	2.22 (1.33)
Median [Min, Max]	2.07 [0.570, 8.00]	1.62 [0.880, 5.21]	1.84 [0.600, 5.77]	1.80 [0.570, 8.00]
Missing	58 (53.2%)	34 (54.8%)	44 (61.1%)	136 (56.0%)
scr_day13_post_terli
Mean (SD)	2.45 (1.53)	2.04 (1.18)	2.15 (1.41)	2.26 (1.41)
Median [Min, Max]	2.16 [0.650, 9.60]	1.64 [0.950, 5.66]	1.92 [0.700, 5.76]	1.94 [0.650, 9.60]
Missing	60 (55.0%)	34 (54.8%)	45 (62.5%)	139 (57.2%)
scr_day14_post_terli
Mean (SD)	2.49 (1.43)	2.00 (1.05)	2.00 (1.32)	2.25 (1.33)
Median [Min, Max]	2.27 [0.530, 8.40]	1.54 [0.840, 4.77]	1.72 [0.520, 5.86]	1.87 [0.520, 8.40]
Missing	59 (54.1%)	39 (62.9%)	47 (65.3%)	145 (59.7%)
days_to_hrsreversal
Mean (SD)	27.8 (32.7)	13.9 (9.18)	13.9 (16.4)	16.8 (20.0)
Median [Min, Max]	20.5 [1.00, 154]	12.0 [3.00, 39.0]	11.0 [3.00, 113]	11.0 [1.00, 154]
Missing	89 (81.7%)	33 (53.2%)	25 (34.7%)	147 (60.5%)
days_to_hrsrecovery
Mean (SD)	28.4 (12.3)	16.4 (9.98)	14.2 (18.3)	16.5 (16.3)
Median [Min, Max]	27.0 [11.0, 49.0]	14.0 [3.00, 39.0]	10.0 [3.00, 114]	12.0 [3.00, 114]
Missing	102 (93.6%)	47 (75.8%)	37 (51.4%)	186 (76.5%)
recurrentaki_number
Mean (SD)	1.37 (0.684)	1.08 (0.277)	1.29 (0.464)	1.27 (0.522)
Median [Min, Max]	1.00 [1.00, 3.00]	1.00 [1.00, 2.00]	1.00 [1.00, 2.00]	1.00 [1.00, 3.00]
Missing	90 (82.6%)	49 (79.0%)	48 (66.7%)	187 (77.0%)
days_to_recurrentaki
Mean (SD)	27.6 (24.3)	25.2 (31.7)	21.8 (16.3)	24.6 (23.0)
Median [Min, Max]	16.0 [10.0, 107]	16.0 [11.0, 128]	19.0 [8.00, 89.0]	16.0 [8.00, 128]
Missing	90 (82.6%)	49 (79.0%)	48 (66.7%)	187 (77.0%)
nadirhospit_scr
Mean (SD)	1.50 (0.827)	1.40 (0.645)	1.27 (0.461)	1.40 (0.695)
Median [Min, Max]	1.29 [0.270, 3.93]	1.21 [0.470, 3.86]	1.25 [0.460, 2.99]	1.24 [0.270, 3.93]
Missing	0 (0%)	2 (3.2%)	0 (0%)	2 (0.8%)
peakhospit_scr
Mean (SD)	4.25 (1.59)	3.48 (1.21)	2.99 (1.07)	3.68 (1.46)
Median [Min, Max]	4.09 [1.58, 11.1]	3.19 [1.72, 6.69]	2.80 [1.40, 8.00]	3.39 [1.40, 11.1]
Missing	0 (0%)	2 (3.2%)	0 (0%)	2 (0.8%)
days_to_peakhospitscr
Mean (SD)	14.3 (16.6)	8.90 (10.3)	6.43 (7.80)	10.6 (13.4)
Median [Min, Max]	11.0 [0, 144]	4.50 [0, 51.0]	3.00 [0, 44.0]	7.00 [0, 144]
Missing	0 (0%)	2 (3.2%)	0 (0%)	2 (0.8%)
days_to_rrt
Mean (SD)	11.9 (6.74)	14.1 (9.38)	13.7 (9.55)	12.6 (7.71)
Median [Min, Max]	11.0 [1.00, 26.0]	11.0 [2.00, 33.0]	12.0 [0, 30.0]	11.0 [0, 33.0]
Missing	60 (55.0%)	47 (75.8%)	61 (84.7%)	168 (69.1%)

num_followup_variables hrs_responders

num_followup_variables_formula <- as.formula(paste("~", paste(num_followup_variables, collapse = "+"),"|hrs_responders"))
table1(num_followup_variables_formula,data = final_master%>% drop_na(hrs_responders))

	0 (N=109)	1 (N=62)	2 (N=72)	Overall (N=243)
dc_aki_recurrence_number
Mean (SD)	1.00 (0)	1.42 (0.996)	1.57 (1.26)	1.38 (1.03)
Median [Min, Max]	1.00 [1.00, 1.00]	1.00 [0, 4.00]	1.00 [1.00, 7.00]	1.00 [0, 7.00]
Missing	94 (86.2%)	50 (80.6%)	44 (61.1%)	188 (77.4%)
days_to_aki_recurrence
Mean (SD)	52.3 (89.5)	42.4 (112)	18.5 (16.4)	33.1 (70.1)
Median [Min, Max]	23.5 [2.00, 369]	8.00 [3.00, 379]	13.5 [1.00, 58.0]	13.0 [1.00, 379]
Missing	93 (85.3%)	51 (82.3%)	44 (61.1%)	188 (77.4%)
dc_days_lastencounter
Mean (SD)	165 (111)	134 (93.2)	158 (126)	154 (112)
Median [Min, Max]	124 [0, 472]	106 [0, 450]	105 [27.0, 561]	111 [0, 561]
Missing	59 (54.1%)	27 (43.5%)	27 (37.5%)	113 (46.5%)
dc_days_to_death
Mean (SD)	49.8 (43.1)	63.6 (38.0)	67.3 (35.3)	58.5 (40.3)
Median [Min, Max]	90.0 [0, 90.0]	90.0 [0, 90.0]	90.0 [0, 95.0]	90.0 [0, 95.0]
Missing	0 (0%)	1 (1.6%)	0 (0%)	1 (0.4%)
days_to_lost_to_followup
Mean (SD)	1.70 (10.2)	1.15 (9.02)	0.847 (7.19)	1.30 (9.09)
Median [Min, Max]	0 [0, 85.0]	0 [0, 71.0]	0 [0, 61.0]	0 [0, 85.0]
dc_days_lt
Mean (SD)	198 (215)	194 (264)	143 (191)	176 (217)
Median [Min, Max]	85.0 [13.0, 692]	99.0 [5.00, 855]	51.0 [2.00, 547]	78.5 [2.00, 855]
Missing	92 (84.4%)	50 (80.6%)	55 (76.4%)	197 (81.1%)
dc_scr_90day_postlt_value
Mean (SD)	1.61 (0.709)	1.62 (0.736)	1.51 (0.760)	1.58 (0.726)
Median [Min, Max]	1.44 [0.420, 3.60]	1.49 [0.800, 2.96]	1.27 [0.690, 3.92]	1.32 [0.420, 3.92]
Missing	81 (74.3%)	43 (69.4%)	46 (63.9%)	170 (70.0%)
dc_days_to_90dayscr_lt
Mean (SD)	217 (179)	159 (176)	188 (162)	191 (169)
Median [Min, Max]	146 [0, 613]	118 [27.0, 662]	109 [22.0, 642]	118 [0, 662]
Missing	94 (86.2%)	51 (82.3%)	55 (76.4%)	200 (82.3%)
dc_days_to_neph_followup
Mean (SD)	59.2 (50.4)	33.4 (18.9)	36.4 (26.5)	44.3 (37.3)
Median [Min, Max]	45.5 [3.00, 168]	33.0 [4.00, 68.0]	25.0 [15.0, 103]	33.0 [3.00, 168]
Missing	95 (87.2%)	51 (82.3%)	61 (84.7%)	207 (85.2%)
dc_days_to_gihep_followup
Mean (SD)	47.3 (54.8)	47.6 (91.1)	32.7 (27.9)	42.1 (61.9)
Median [Min, Max]	31.0 [2.00, 230]	17.0 [1.00, 368]	25.0 [2.00, 103]	22.0 [1.00, 368]
Missing	79 (72.5%)	33 (53.2%)	39 (54.2%)	151 (62.1%)
dc_scr30_value
Mean (SD)	2.02 (1.04)	1.99 (1.36)	1.81 (1.18)	1.94 (1.18)
Median [Min, Max]	1.80 [0.440, 4.70]	1.64 [0.590, 6.15]	1.55 [0.620, 6.10]	1.69 [0.440, 6.15]
Missing	65 (59.6%)	26 (41.9%)	31 (43.1%)	122 (50.2%)
dc_days_scr30
Mean (SD)	38.0 (16.0)	35.6 (12.2)	37.4 (14.3)	37.1 (14.3)
Median [Min, Max]	32.0 [15.0, 111]	32.0 [17.0, 84.0]	32.0 [1.00, 93.0]	32.0 [1.00, 111]
Missing	65 (59.6%)	26 (41.9%)	31 (43.1%)	122 (50.2%)
dc_scr60_value
Mean (SD)	1.71 (0.826)	1.78 (0.959)	1.74 (0.838)	1.74 (0.865)
Median [Min, Max]	1.40 [0.480, 4.37]	1.45 [0.590, 4.71]	1.45 [0.700, 3.93]	1.45 [0.480, 4.71]
Missing	72 (66.1%)	29 (46.8%)	35 (48.6%)	136 (56.0%)
dc_days_scr60
Mean (SD)	67.2 (18.1)	68.1 (21.5)	64.1 (15.9)	66.4 (18.4)
Median [Min, Max]	63.0 [15.0, 143]	63.0 [17.0, 143]	62.0 [1.00, 114]	63.0 [1.00, 143]
Missing	72 (66.1%)	29 (46.8%)	35 (48.6%)	136 (56.0%)
dc_scr90_value
Mean (SD)	1.66 (0.986)	1.74 (0.902)	1.62 (0.720)	1.67 (0.874)
Median [Min, Max]	1.43 [0.460, 6.18]	1.49 [0.530, 4.10]	1.50 [0.600, 3.59]	1.49 [0.460, 6.18]
Missing	67 (61.5%)	32 (51.6%)	35 (48.6%)	134 (55.1%)
dc_days_scr91
Mean (SD)	105 (32.7)	107 (39.5)	114 (48.8)	109 (40.4)
Median [Min, Max]	95.0 [15.0, 255]	96.5 [17.0, 265]	97.0 [1.00, 279]	97.0 [1.00, 279]
Missing	67 (61.5%)	32 (51.6%)	35 (48.6%)	134 (55.1%)
days_to_last_encounter_1yr
Mean (SD)	234 (167)	268 (193)	230 (176)	242 (175)
Median [Min, Max]	257 [10.0, 472]	340 [0, 516]	259 [4.00, 562]	278 [0, 562]
Missing	94 (86.2%)	49 (79.0%)	52 (72.2%)	195 (80.2%)
days_to_death_1yr
Mean (SD)	23.0 (73.8)	65.1 (110)	52.3 (72.8)	41.4 (85.5)
Median [Min, Max]	0 [0, 374]	19.0 [0, 382]	28.0 [0, 279]	3.00 [0, 382]
Missing	58 (53.2%)	35 (56.5%)	45 (62.5%)	138 (56.8%)
days_lastencounter_1yr
Mean (SD)	110 (166)	71.0 (NA)	76.4 (68.7)	91.0 (115)
Median [Min, Max]	10.0 [0, 387]	71.0 [71.0, 71.0]	61.0 [0, 171]	61.0 [0, 387]
Missing	104 (95.4%)	61 (98.4%)	67 (93.1%)	232 (95.5%)
scr_value_1yr
Mean (SD)	1.40 (0.537)	1.67 (0.535)	1.75 (1.40)	1.60 (0.980)
Median [Min, Max]	1.24 [0.570, 2.67]	1.55 [1.00, 2.87]	1.33 [0.400, 6.67]	1.40 [0.400, 6.67]
Missing	85 (78.0%)	46 (74.2%)	45 (62.5%)	176 (72.4%)
days_to_scr_1yr
Mean (SD)	302 (120)	304 (121)	271 (126)	290 (122)
Median [Min, Max]	344 [3.00, 484]	351 [17.0, 424]	337 [0, 402]	339 [0, 484]
Missing	85 (78.0%)	46 (74.2%)	45 (62.5%)	176 (72.4%)
days_to_lt_1yr
Mean (SD)	58.5 (79.8)	38.4 (47.2)	48.4 (51.6)	49.7 (62.9)
Median [Min, Max]	27.0 [0, 360]	22.0 [5.00, 156]	31.0 [4.00, 175]	25.5 [0, 360]
Missing	86 (78.9%)	46 (74.2%)	53 (73.6%)	185 (76.1%)

HRS_reversal_new KM

hrs_responders KM

# hrs_responders_cat_2 KM

ae by HRS_Criteria

ae by HRS_Criteria

ae by terli_route_day0 missing terli_route_day0

ae by meld_35

ae by criteria_2

## # A tibble: 243 × 1,697
##    subjectid ace_arb_preadmission admit_admitroute admit_admitservice
##    <chr>     <fct>                <fct>            <fct>             
##  1 BID-001   0                    1                3                 
##  2 BID-002   0                    1                2                 
##  3 BID-003   1                    2                3                 
##  4 BID-004   0                    3                4                 
##  5 BID-005   1                    2                2                 
##  6 BID-006   0                    2                2                 
##  7 BID-007   0                    2                1                 
##  8 BID-008   0                    1                3                 
##  9 BID-009   0                    1                3                 
## 10 BID-010   0                    2                2                 
## # ℹ 233 more rows
## # ℹ 1,693 more variables: admit_ascites <fct>, admit_reason___1 <dbl>,
## #   admit_reason___2 <dbl>, admit_reason___3 <dbl>, admit_reason___4 <dbl>,
## #   admit_reason___5 <dbl>, admit_reason___6 <dbl>, admit_reason___7 <dbl>,
## #   admit_reason_other <chr>, age <dbl>, aki_dbp <dbl>,
## #   aki_details_complete <dbl>, aki_events_previous90days <fct>,
## #   aki_height <dbl>, aki_hr <dbl>, aki_map <dbl>, aki_pao2 <dbl>, …

scr_category by HRS_reversal_new

## 
##  
##    Cell Contents
## |-------------------------|
## |                       N |
## | Chi-square contribution |
## |           N / Row Total |
## |           N / Col Total |
## |         N / Table Total |
## |-------------------------|
## 
##  
## Total Observations in Table:  243 
## 
##  
##                | a$HRS_reversal_new 
## a$scr_category |         0 |         1 | Row Total | 
## ---------------|-----------|-----------|-----------|
##           <1.5 |         3 |         3 |         6 | 
##                |     0.318 |     0.712 |           | 
##                |     0.500 |     0.500 |     0.025 | 
##                |     0.018 |     0.040 |           | 
##                |     0.012 |     0.012 |           | 
## ---------------|-----------|-----------|-----------|
##          1.5-2 |        15 |        22 |        37 | 
##                |     4.376 |     9.802 |           | 
##                |     0.405 |     0.595 |     0.152 | 
##                |     0.089 |     0.293 |           | 
##                |     0.062 |     0.091 |           | 
## ---------------|-----------|-----------|-----------|
##          2-2.5 |        25 |        20 |        45 | 
##                |     1.200 |     2.689 |           | 
##                |     0.556 |     0.444 |     0.185 | 
##                |     0.149 |     0.267 |           | 
##                |     0.103 |     0.082 |           | 
## ---------------|-----------|-----------|-----------|
##          2.5-3 |        41 |        17 |        58 | 
##                |     0.020 |     0.045 |           | 
##                |     0.707 |     0.293 |     0.239 | 
##                |     0.244 |     0.227 |           | 
##                |     0.169 |     0.070 |           | 
## ---------------|-----------|-----------|-----------|
##          3-3.5 |        24 |         6 |        30 | 
##                |     0.512 |     1.147 |           | 
##                |     0.800 |     0.200 |     0.123 | 
##                |     0.143 |     0.080 |           | 
##                |     0.099 |     0.025 |           | 
## ---------------|-----------|-----------|-----------|
##          3.5-4 |        21 |         4 |        25 | 
##                |     0.799 |     1.790 |           | 
##                |     0.840 |     0.160 |     0.103 | 
##                |     0.125 |     0.053 |           | 
##                |     0.086 |     0.016 |           | 
## ---------------|-----------|-----------|-----------|
##          4-4.5 |        21 |         2 |        23 | 
##                |     1.635 |     3.662 |           | 
##                |     0.913 |     0.087 |     0.095 | 
##                |     0.125 |     0.027 |           | 
##                |     0.086 |     0.008 |           | 
## ---------------|-----------|-----------|-----------|
##          4.5-5 |         9 |         0 |         9 | 
##                |     1.240 |     2.778 |           | 
##                |     1.000 |     0.000 |     0.037 | 
##                |     0.054 |     0.000 |           | 
##                |     0.037 |     0.000 |           | 
## ---------------|-----------|-----------|-----------|
##             >5 |         9 |         1 |        10 | 
##                |     0.630 |     1.410 |           | 
##                |     0.900 |     0.100 |     0.041 | 
##                |     0.054 |     0.013 |           | 
##                |     0.037 |     0.004 |           | 
## ---------------|-----------|-----------|-----------|
##   Column Total |       168 |        75 |       243 | 
##                |     0.691 |     0.309 |           | 
## ---------------|-----------|-----------|-----------|
## 
## 

scr_category by hrs_responders_cat_2

## 
##  
##    Cell Contents
## |-------------------------|
## |                       N |
## | Chi-square contribution |
## |           N / Row Total |
## |           N / Col Total |
## |         N / Table Total |
## |-------------------------|
## 
##  
## Total Observations in Table:  243 
## 
##  
##                | a$hrs_responders_cat_2 
## a$scr_category |         0 |         1 | Row Total | 
## ---------------|-----------|-----------|-----------|
##           <1.5 |         2 |         4 |         6 | 
##                |     0.178 |     0.144 |           | 
##                |     0.333 |     0.667 |     0.025 | 
##                |     0.018 |     0.030 |           | 
##                |     0.008 |     0.016 |           | 
## ---------------|-----------|-----------|-----------|
##          1.5-2 |        12 |        25 |        37 | 
##                |     1.273 |     1.036 |           | 
##                |     0.324 |     0.676 |     0.152 | 
##                |     0.110 |     0.187 |           | 
##                |     0.049 |     0.103 |           | 
## ---------------|-----------|-----------|-----------|
##          2-2.5 |        17 |        28 |        45 | 
##                |     0.503 |     0.409 |           | 
##                |     0.378 |     0.622 |     0.185 | 
##                |     0.156 |     0.209 |           | 
##                |     0.070 |     0.115 |           | 
## ---------------|-----------|-----------|-----------|
##          2.5-3 |        28 |        30 |        58 | 
##                |     0.151 |     0.123 |           | 
##                |     0.483 |     0.517 |     0.239 | 
##                |     0.257 |     0.224 |           | 
##                |     0.115 |     0.123 |           | 
## ---------------|-----------|-----------|-----------|
##          3-3.5 |        13 |        17 |        30 | 
##                |     0.016 |     0.013 |           | 
##                |     0.433 |     0.567 |     0.123 | 
##                |     0.119 |     0.127 |           | 
##                |     0.053 |     0.070 |           | 
## ---------------|-----------|-----------|-----------|
##          3.5-4 |        14 |        11 |        25 | 
##                |     0.692 |     0.563 |           | 
##                |     0.560 |     0.440 |     0.103 | 
##                |     0.128 |     0.082 |           | 
##                |     0.058 |     0.045 |           | 
## ---------------|-----------|-----------|-----------|
##          4-4.5 |        12 |        11 |        23 | 
##                |     0.275 |     0.223 |           | 
##                |     0.522 |     0.478 |     0.095 | 
##                |     0.110 |     0.082 |           | 
##                |     0.049 |     0.045 |           | 
## ---------------|-----------|-----------|-----------|
##          4.5-5 |         3 |         6 |         9 | 
##                |     0.266 |     0.217 |           | 
##                |     0.333 |     0.667 |     0.037 | 
##                |     0.028 |     0.045 |           | 
##                |     0.012 |     0.025 |           | 
## ---------------|-----------|-----------|-----------|
##             >5 |         8 |         2 |        10 | 
##                |     2.753 |     2.240 |           | 
##                |     0.800 |     0.200 |     0.041 | 
##                |     0.073 |     0.015 |           | 
##                |     0.033 |     0.008 |           | 
## ---------------|-----------|-----------|-----------|
##   Column Total |       109 |       134 |       243 | 
##                |     0.449 |     0.551 |           | 
## ---------------|-----------|-----------|-----------|
## 
## 

quintiles of admit_meld_3_raw by HRS_reversal_new

## 
##  
##    Cell Contents
## |-------------------------|
## |                       N |
## | Chi-square contribution |
## |           N / Row Total |
## |           N / Col Total |
## |         N / Table Total |
## |-------------------------|
## 
##  
## Total Observations in Table:  233 
## 
##  
##                             | a$HRS_reversal_new 
## a$admit_meld_3_raw_quintile |         0 |         1 | Row Total | 
## ----------------------------|-----------|-----------|-----------|
##                           1 |        31 |        18 |        49 | 
##                             |     0.208 |     0.457 |           | 
##                             |     0.633 |     0.367 |     0.210 | 
##                             |     0.194 |     0.247 |           | 
##                             |     0.133 |     0.077 |           | 
## ----------------------------|-----------|-----------|-----------|
##                           2 |        38 |        23 |        61 | 
##                             |     0.361 |     0.791 |           | 
##                             |     0.623 |     0.377 |     0.262 | 
##                             |     0.237 |     0.315 |           | 
##                             |     0.163 |     0.099 |           | 
## ----------------------------|-----------|-----------|-----------|
##                           3 |        24 |        15 |        39 | 
##                             |     0.289 |     0.633 |           | 
##                             |     0.615 |     0.385 |     0.167 | 
##                             |     0.150 |     0.205 |           | 
##                             |     0.103 |     0.064 |           | 
## ----------------------------|-----------|-----------|-----------|
##                           4 |        30 |         8 |        38 | 
##                             |     0.585 |     1.281 |           | 
##                             |     0.789 |     0.211 |     0.163 | 
##                             |     0.188 |     0.110 |           | 
##                             |     0.129 |     0.034 |           | 
## ----------------------------|-----------|-----------|-----------|
##                           5 |        37 |         9 |        46 | 
##                             |     0.927 |     2.032 |           | 
##                             |     0.804 |     0.196 |     0.197 | 
##                             |     0.231 |     0.123 |           | 
##                             |     0.159 |     0.039 |           | 
## ----------------------------|-----------|-----------|-----------|
##                Column Total |       160 |        73 |       233 | 
##                             |     0.687 |     0.313 |           | 
## ----------------------------|-----------|-----------|-----------|
## 
## 

quintiles of tbili_admit by HRS_reversal_new

## 
##  
##    Cell Contents
## |-------------------------|
## |                       N |
## | Chi-square contribution |
## |           N / Row Total |
## |           N / Col Total |
## |         N / Table Total |
## |-------------------------|
## 
##  
## Total Observations in Table:  233 
## 
##  
##                        | a$HRS_reversal_new 
## a$tbili_admit_quintile |         0 |         1 | Row Total | 
## -----------------------|-----------|-----------|-----------|
##                      1 |        30 |        18 |        48 | 
##                        |     0.266 |     0.583 |           | 
##                        |     0.625 |     0.375 |     0.206 | 
##                        |     0.188 |     0.247 |           | 
##                        |     0.129 |     0.077 |           | 
## -----------------------|-----------|-----------|-----------|
##                      2 |        31 |        15 |        46 | 
##                        |     0.011 |     0.024 |           | 
##                        |     0.674 |     0.326 |     0.197 | 
##                        |     0.194 |     0.205 |           | 
##                        |     0.133 |     0.064 |           | 
## -----------------------|-----------|-----------|-----------|
##                      3 |        31 |        15 |        46 | 
##                        |     0.011 |     0.024 |           | 
##                        |     0.674 |     0.326 |     0.197 | 
##                        |     0.194 |     0.205 |           | 
##                        |     0.133 |     0.064 |           | 
## -----------------------|-----------|-----------|-----------|
##                      4 |        33 |        13 |        46 | 
##                        |     0.063 |     0.138 |           | 
##                        |     0.717 |     0.283 |     0.197 | 
##                        |     0.206 |     0.178 |           | 
##                        |     0.142 |     0.056 |           | 
## -----------------------|-----------|-----------|-----------|
##                      5 |        35 |        12 |        47 | 
##                        |     0.230 |     0.504 |           | 
##                        |     0.745 |     0.255 |     0.202 | 
##                        |     0.219 |     0.164 |           | 
##                        |     0.150 |     0.052 |           | 
## -----------------------|-----------|-----------|-----------|
##           Column Total |       160 |        73 |       233 | 
##                        |     0.687 |     0.313 |           | 
## -----------------------|-----------|-----------|-----------|
## 
## 

1 Unviariate Logistic regression: time_to_death_status_90days

2 Multivariate Logistic regression:time_to_death_status_90days

3 Unviariate Logistic regression: time_to_death_status_90days

4 Multivariate Logistic regression:time_to_death_status_90days

5 Unviariate Logistic regression: transplant_outcome

6 Multivariate Logistic regression:transplant_outcome

7 Unviariate Logistic regression: transplant_outcome

8 Multivariate Logistic regression:transplant_outcome

9.1 Unviariate cmp: time_to_death_status_90days_cmp failcode=1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		0.56	0.38, 0.83	0.004
age	243	1.01	0.99, 1.03	0.410
race_2	243
0		—	—
1		1.06	0.62, 1.80	0.830
hispanic	243
0		—	—
1		0.76	0.43, 1.36	0.360
admit_meld_3	243	1.02	1.00, 1.05	0.070
1 HR = Hazard Ratio, CI = Confidence Interval

9.2 Unviariate cmp: time_to_death_status_90days_cmp failcode=2

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		1.01	0.60, 1.69	0.980
age	243	1.00	0.98, 1.02	0.970
race_2	243
0		—	—
1		0.83	0.40, 1.71	0.610
hispanic	243
0		—	—
1		1.55	0.82, 2.94	0.180
admit_meld_3	243	1.02	0.99, 1.06	0.170
1 HR = Hazard Ratio, CI = Confidence Interval

10.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		0.57	0.38, 0.85	0.006
age	243	1.02	1.00, 1.04	0.10
race_2	243
0		—	—
1		1.11	0.63, 1.93	0.7
hispanic	243
0		—	—
1		0.86	0.49, 1.50	0.6
admit_meld_3	243	1.03	1.00, 1.06	0.041
1 HR = Hazard Ratio, CI = Confidence Interval

10.2 Multiviariate cmp: time_to_death_status_90days_cmp failcode=2

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		1.03	0.61, 1.75	0.9
age	243	1.01	0.99, 1.04	0.4
race_2	243
0		—	—
1		0.90	0.43, 1.87	0.8
hispanic	243
0		—	—
1		1.63	0.83, 3.21	0.2
admit_meld_3	243	1.03	0.99, 1.07	0.13
1 HR = Hazard Ratio, CI = Confidence Interval

11.1 Unviariate cmp: time_to_death_status_90days_cmp failcode=1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.66	0.42, 1.02	0.059
age	243	1.01	0.99, 1.03	0.410
race_2	243
0		—	—
1		1.06	0.62, 1.80	0.830
hispanic	243
0		—	—
1		0.76	0.43, 1.36	0.360
admit_meld_3	243	1.02	1.00, 1.05	0.070
1 HR = Hazard Ratio, CI = Confidence Interval

11.2 Unviariate cmp: time_to_death_status_90days_cmp failcode=2

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.70	0.38, 1.28	0.250
age	243	1.00	0.98, 1.02	0.970
race_2	243
0		—	—
1		0.83	0.40, 1.71	0.610
hispanic	243
0		—	—
1		1.55	0.82, 2.94	0.180
admit_meld_3	243	1.02	0.99, 1.06	0.170
1 HR = Hazard Ratio, CI = Confidence Interval

12.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.71	0.45, 1.12	0.14
age	243	1.01	0.99, 1.04	0.2
race_2	243
0		—	—
1		1.13	0.65, 1.97	0.7
hispanic	243
0		—	—
1		0.79	0.45, 1.40	0.4
admit_meld_3	243	1.03	1.00, 1.06	0.059
1 HR = Hazard Ratio, CI = Confidence Interval

12.2 Multiviariate cmp: time_to_death_status_90days_cmp failcode=2

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.78	0.42, 1.45	0.4
age	243	1.01	0.98, 1.03	0.5
race_2	243
0		—	—
1		0.91	0.44, 1.88	0.8
hispanic	243
0		—	—
1		1.57	0.78, 3.16	0.2
admit_meld_3	243	1.03	0.99, 1.06	0.2
1 HR = Hazard Ratio, CI = Confidence Interval

13 Unviariate Logistic regression: transplant_outcome

Characteristic	N	OR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.71	0.32, 1.53	0.394
age	141	1.01	0.97, 1.04	0.735
race_2	141
0		—	—
1		1.05	0.41, 2.82	0.926
hispanic	141
0		—	—
1		1.74	0.73, 4.13	0.206
admit_meld_3	141	1.01	0.96, 1.06	0.729
1 OR = Odds Ratio, CI = Confidence Interval

14 Multivariate Logistic regression:transplant_outcome

Characteristic	N	OR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.72	0.32, 1.57	0.4
age	141	1.01	0.98, 1.05	0.5
race_2	141
0		—	—
1		1.23	0.47, 3.44	0.7
hispanic	141
0		—	—
1		1.95	0.79, 4.88	0.15
admit_meld_3	141	1.01	0.96, 1.06	0.7
1 OR = Odds Ratio, CI = Confidence Interval

15 Unviariate Logistic regression: transplant_outcome

Characteristic	N	OR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		1.00	0.50, 1.97	0.990
age	141	1.01	0.97, 1.04	0.735
race_2	141
0		—	—
1		1.05	0.41, 2.82	0.926
hispanic	141
0		—	—
1		1.74	0.73, 4.13	0.206
admit_meld_3	141	1.01	0.96, 1.06	0.729
1 OR = Odds Ratio, CI = Confidence Interval

16 Multivariate Logistic regression:transplant_outcome

Characteristic	N	OR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		0.93	0.46, 1.86	0.8
age	141	1.01	0.98, 1.05	0.5
race_2	141
0		—	—
1		1.21	0.46, 3.37	0.7
hispanic	141
0		—	—
1		1.95	0.79, 4.91	0.15
admit_meld_3	141	1.01	0.96, 1.07	0.6
1 OR = Odds Ratio, CI = Confidence Interval

5 Unviariate Logistic regression: transplant_outcome listed_transplant

Characteristic	N	OR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.71	0.32, 1.53	0.394
age	141	1.01	0.97, 1.04	0.735
race_2	141
0		—	—
1		1.05	0.41, 2.82	0.926
hispanic	141
0		—	—
1		1.74	0.73, 4.13	0.206
admit_meld_3	141	1.01	0.96, 1.06	0.729
1 OR = Odds Ratio, CI = Confidence Interval

6 Multivariate Logistic regression:transplant_outcome listed_transplant

Characteristic	N	OR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.72	0.32, 1.57	0.4
age	141	1.01	0.98, 1.05	0.5
race_2	141
0		—	—
1		1.23	0.47, 3.44	0.7
hispanic	141
0		—	—
1		1.95	0.79, 4.88	0.15
admit_meld_3	141	1.01	0.96, 1.06	0.7
1 OR = Odds Ratio, CI = Confidence Interval

7 Unviariate Logistic regression: transplant_outcome listed_transplant

Characteristic	N	OR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		1.00	0.50, 1.97	0.990
age	141	1.01	0.97, 1.04	0.735
race_2	141
0		—	—
1		1.05	0.41, 2.82	0.926
hispanic	141
0		—	—
1		1.74	0.73, 4.13	0.206
admit_meld_3	141	1.01	0.96, 1.06	0.729
1 OR = Odds Ratio, CI = Confidence Interval

8 Multivariate Logistic regression:transplant_outcome listed_transplant

Characteristic	N	OR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		0.93	0.46, 1.86	0.8
age	141	1.01	0.98, 1.05	0.5
race_2	141
0		—	—
1		1.21	0.46, 3.37	0.7
hispanic	141
0		—	—
1		1.95	0.79, 4.91	0.15
admit_meld_3	141	1.01	0.96, 1.07	0.6
1 OR = Odds Ratio, CI = Confidence Interval

9.1 Unviariate cmp: time_to_death_status_90days_cmp failcode=1 listed_transplant==1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		0.50	0.27, 0.91	0.024
age	141	1.00	0.97, 1.03	0.910
race_2	141
0		—	—
1		1.08	0.47, 2.49	0.860
hispanic	141
0		—	—
1		1.08	0.51, 2.28	0.830
admit_meld_3	141	1.03	0.99, 1.08	0.170
1 HR = Hazard Ratio, CI = Confidence Interval

9.2 Unviariate cmp: time_to_death_status_90days_cmp failcode=2 final_master_listed=1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		1.01	0.59, 1.71	0.980
age	141	1.00	0.98, 1.03	0.720
race_2	141
0		—	—
1		0.96	0.44, 2.09	0.910
hispanic	141
0		—	—
1		1.41	0.75, 2.68	0.290
admit_meld_3	141	1.00	0.97, 1.04	0.800
1 HR = Hazard Ratio, CI = Confidence Interval

10.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1 final_master_listed=1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		0.49	0.26, 0.92	0.027
age	141	1.01	0.97, 1.04	0.7
race_2	141
0		—	—
1		1.24	0.53, 2.89	0.6
hispanic	141
0		—	—
1		1.32	0.61, 2.86	0.5
admit_meld_3	141	1.03	0.98, 1.08	0.2
1 HR = Hazard Ratio, CI = Confidence Interval

10.2 Multiviariate cmp: time_to_death_status_90days_cmp failcode=2 final_master_listed=1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		0.97	0.57, 1.66	>0.9
age	141	1.01	0.98, 1.04	0.5
race_2	141
0		—	—
1		1.05	0.46, 2.36	>0.9
hispanic	141
0		—	—
1		1.55	0.75, 3.21	0.2
admit_meld_3	141	1.01	0.97, 1.04	0.7
1 HR = Hazard Ratio, CI = Confidence Interval

11.1 Unviariate cmp: time_to_death_status_90days_cmp failcode=1 final_master_listed=1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.56	0.27, 1.18	0.130
age	141	1.00	0.97, 1.03	0.910
race_2	141
0		—	—
1		1.08	0.47, 2.49	0.860
hispanic	141
0		—	—
1		1.08	0.51, 2.28	0.830
admit_meld_3	141	1.03	0.99, 1.08	0.170
1 HR = Hazard Ratio, CI = Confidence Interval

11.2 Unviariate cmp: time_to_death_status_90days_cmp failcode=2 final_master_listed=1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.81	0.44, 1.52	0.520
age	141	1.00	0.98, 1.03	0.720
race_2	141
0		—	—
1		0.96	0.44, 2.09	0.910
hispanic	141
0		—	—
1		1.41	0.75, 2.68	0.290
admit_meld_3	141	1.00	0.97, 1.04	0.800
1 HR = Hazard Ratio, CI = Confidence Interval

12.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1 final_master_listed=1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.59	0.27, 1.31	0.2
age	141	1.00	0.97, 1.04	>0.9
race_2	141
0		—	—
1		1.19	0.52, 2.72	0.7
hispanic	141
0		—	—
1		1.14	0.53, 2.45	0.8
admit_meld_3	141	1.03	0.98, 1.08	0.3
1 HR = Hazard Ratio, CI = Confidence Interval

12.2 Multiviariate cmp: time_to_death_status_90days_cmp failcode=2 final_master_listed=1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.84	0.44, 1.60	0.6
age	141	1.01	0.98, 1.04	0.5
race_2	141
0		—	—
1		1.06	0.47, 2.37	0.9
hispanic	141
0		—	—
1		1.53	0.74, 3.17	0.3
admit_meld_3	141	1.01	0.97, 1.04	0.8
1 HR = Hazard Ratio, CI = Confidence Interval

16 Unviariate coxph regression: time_to_death_90days

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.70	0.45, 1.08	0.109
age	243	1.01	0.99, 1.03	0.351
race_2	243
0		—	—
1		1.11	0.63, 1.95	0.719
hispanic	243
0		—	—
1		0.73	0.41, 1.30	0.286
admit_meld_3	243	1.02	1.00, 1.05	0.075
listed_transplant	243
0		—	—
1		0.43	0.29, 0.63	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.70	0.45, 1.08	0.109
age	243	1.01	0.99, 1.03	0.351
race_2	243
0		—	—
1		1.11	0.63, 1.95	0.719
hispanic	243
0		—	—
1		0.73	0.41, 1.30	0.286
admit_meld_3	243	1.02	1.00, 1.05	0.075
listed_transplant	243
0		—	—
1		0.43	0.29, 0.63	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

17 Multivariate coxph regression: time_to_death_90days

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.67	0.43, 1.06	0.089
age	243	1.02	1.00, 1.04	0.086
race_2	243
0		—	—
1		1.18	0.67, 2.09	0.6
hispanic	243
0		—	—
1		0.78	0.44, 1.41	0.4
admit_meld_3	243	1.04	1.01, 1.07	0.014
listed_transplant	243
0		—	—
1		0.39	0.26, 0.58	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

18 Unviariate coxph regression:

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		0.57	0.38, 0.84	0.004
age	243	1.01	0.99, 1.03	0.351
race_2	243
0		—	—
1		1.11	0.63, 1.95	0.719
hispanic	243
0		—	—
1		0.73	0.41, 1.30	0.286
admit_meld_3	243	1.02	1.00, 1.05	0.075
listed_transplant	243
0		—	—
1		0.43	0.29, 0.63	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

19 Multivariate coxph regression:

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		0.53	0.35, 0.79	0.002
age	243	1.02	1.00, 1.04	0.025
race_2	243
0		—	—
1		1.12	0.63, 1.97	0.7
hispanic	243
0		—	—
1		0.84	0.47, 1.50	0.6
admit_meld_3	243	1.04	1.01, 1.07	0.008
listed_transplant	243
0		—	—
1		0.38	0.26, 0.57	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

20 Unviariate coxph regression: transplant_outcome

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.69	0.38, 1.25	0.222
age	243	1.00	0.98, 1.02	0.965
race_2	243
0		—	—
1		0.84	0.41, 1.72	0.638
hispanic	243
0		—	—
1		1.71	0.92, 3.17	0.088
admit_meld_3	243	1.02	0.99, 1.06	0.190
1 HR = Hazard Ratio, CI = Confidence Interval

21 Multivariate coxph regression:transplant_outcome

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.77	0.42, 1.44	0.4
age	243	1.01	0.98, 1.04	0.4
race_2	243
0		—	—
1		0.93	0.45, 1.90	0.8
hispanic	243
0		—	—
1		1.76	0.93, 3.35	0.084
admit_meld_3	243	1.03	0.99, 1.07	0.2
1 HR = Hazard Ratio, CI = Confidence Interval

22 Unviariate coxph regression: transplant_outcome

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		0.99	0.59, 1.66	0.973
age	243	1.00	0.98, 1.02	0.965
race_2	243
0		—	—
1		0.84	0.41, 1.72	0.638
hispanic	243
0		—	—
1		1.71	0.92, 3.17	0.088
admit_meld_3	243	1.02	0.99, 1.06	0.190
1 HR = Hazard Ratio, CI = Confidence Interval

23 Multivariate coxph regression:transplant_outcome

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		1.02	0.60, 1.73	>0.9
age	243	1.01	0.99, 1.04	0.4
race_2	243
0		—	—
1		0.92	0.45, 1.88	0.8
hispanic	243
0		—	—
1		1.83	0.97, 3.46	0.064
admit_meld_3	243	1.03	0.99, 1.07	0.12
1 HR = Hazard Ratio, CI = Confidence Interval

Map

added 1 Unviariate cmp: time_to_death_status_90days_cmp failcode=1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		0.56	0.38, 0.83	0.004
age	243	1.01	0.99, 1.03	0.410
race_2	243
0		—	—
1		1.06	0.62, 1.80	0.830
hispanic	243
0		—	—
1		0.76	0.43, 1.36	0.360
admit_meld_3	243	1.02	1.00, 1.05	0.070
1 HR = Hazard Ratio, CI = Confidence Interval

added 1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	243
0		—	—
1		0.57	0.38, 0.85	0.006
age	243	1.02	1.00, 1.04	0.10
race_2	243
0		—	—
1		1.11	0.63, 1.93	0.7
hispanic	243
0		—	—
1		0.86	0.49, 1.50	0.6
admit_meld_3	243	1.03	1.00, 1.06	0.041
1 HR = Hazard Ratio, CI = Confidence Interval

added 2 Unviariate cmp: time_to_death_status_90days_cmp failcode=1 HRS_criteria_3 == 1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	119
0		—	—
1		0.69	0.42, 1.14	0.150
age	119	1.03	1.01, 1.06	0.013
race_2	119
0		—	—
1		2.56	0.95, 6.90	0.063
hispanic	119
0		—	—
1		0.75	0.33, 1.69	0.480
admit_meld_3	119	0.98	0.94, 1.02	0.360
1 HR = Hazard Ratio, CI = Confidence Interval

added 2 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1 HRS_criteria_3 == 1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	119
0		—	—
1		0.69	0.41, 1.16	0.2
age	119	1.03	1.00, 1.06	0.040
race_2	119
0		—	—
1		2.28	0.86, 6.06	0.10
hispanic	119
0		—	—
1		0.88	0.37, 2.08	0.8
admit_meld_3	119	1.00	0.96, 1.04	>0.9
1 HR = Hazard Ratio, CI = Confidence Interval

added 3 Unviariate cmp: time_to_death_status_90days_cmp failcode=1 HRS_criteria_3 == 0

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	124
0		—	—
1		0.52	0.28, 0.97	0.040
age	124	0.98	0.95, 1.01	0.270
race_2	124
0		—	—
1		0.47	0.24, 0.92	0.028
hispanic	124
0		—	—
1		0.90	0.40, 2.04	0.810
admit_meld_3	124	1.04	0.99, 1.09	0.110
1 HR = Hazard Ratio, CI = Confidence Interval

added 3 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1 HRS_criteria_3 == 0

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	124
0		—	—
1		0.50	0.26, 0.94	0.032
age	124	0.99	0.96, 1.02	0.5
race_2	124
0		—	—
1		0.44	0.21, 0.90	0.025
hispanic	124
0		—	—
1		0.67	0.30, 1.49	0.3
admit_meld_3	124	1.04	1.0, 1.09	0.086
1 HR = Hazard Ratio, CI = Confidence Interval

added 4 Unviariate cmp: time_to_death_status_90days_cmp failcode=2 listed_transplant == 1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		1.01	0.59, 1.71	0.980
age	141	1.00	0.98, 1.03	0.720
race_2	141
0		—	—
1		0.96	0.44, 2.09	0.910
hispanic	141
0		—	—
1		1.41	0.75, 2.68	0.290
admit_meld_3	141	1.00	0.97, 1.04	0.800
1 HR = Hazard Ratio, CI = Confidence Interval

added 4 Multiviariate cmp: time_to_death_status_90days_cmp failcode=2 listed_transplant == 1

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	141
0		—	—
1		0.97	0.57, 1.66	>0.9
age	141	1.01	0.98, 1.04	0.5
race_2	141
0		—	—
1		1.05	0.46, 2.36	>0.9
hispanic	141
0		—	—
1		1.55	0.75, 3.21	0.2
admit_meld_3	141	1.01	0.97, 1.04	0.7
1 HR = Hazard Ratio, CI = Confidence Interval

added 5 Unviariate cmp: time_to_death_status_90days_cmp failcode=2 listed_transplant == 0

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	102
0		—	—
1		1.50	0.14, 16.3	0.740
age	102	0.99	0.87, 1.12	0.880
race_2	102
0		—	—
1		0.29	0.03, 3.00	0.300
hispanic	102
0		—	—
1		0.00	0.00, 0.00	<0.001
admit_meld_3	102	1.20	1.04, 1.39	0.016
1 HR = Hazard Ratio, CI = Confidence Interval

added 5 Multiviariate cmp: time_to_death_status_90days_cmp failcode=2 listed_transplant == 0

Characteristic	N	HR1	95% CI1	p-value
hrs_responders_cat_2	102
0		—	—
1		2.29	0.31, 16.9	0.4
age	102	1.08	0.95, 1.22	0.3
race_2	102
0		—	—
1		0.45	0.06, 3.24	0.4
hispanic	102
0		—	—
1		0.00	0.00, 0.00	<0.001
admit_meld_3	102	1.36	1.16, 1.59	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

added 1.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	243
0		—	—
1		0.71	0.45, 1.12	0.14
age	243	1.01	0.99, 1.04	0.2
race_2	243
0		—	—
1		1.13	0.65, 1.97	0.7
hispanic	243
0		—	—
1		0.79	0.45, 1.40	0.4
admit_meld_3	243	1.03	1.00, 1.06	0.059
1 HR = Hazard Ratio, CI = Confidence Interval

added 2.1 Unviariate cmp: time_to_death_status_90days_cmp failcode=1 HRS_criteria_3 == 1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	119
0		—	—
1		0.87	0.50, 1.50	0.610
age	119	1.03	1.01, 1.06	0.013
race_2	119
0		—	—
1		2.56	0.95, 6.90	0.063
hispanic	119
0		—	—
1		0.75	0.33, 1.69	0.480
admit_meld_3	119	0.98	0.94, 1.02	0.360
1 HR = Hazard Ratio, CI = Confidence Interval

added 2.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1 HRS_criteria_3 == 1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	119
0		—	—
1		0.84	0.49, 1.45	0.5
age	119	1.03	1.00, 1.06	0.038
race_2	119
0		—	—
1		2.43	0.90, 6.62	0.081
hispanic	119
0		—	—
1		0.80	0.33, 1.93	0.6
admit_meld_3	119	1.00	0.96, 1.05	0.9
1 HR = Hazard Ratio, CI = Confidence Interval

added 3.1 Unviariate cmp: time_to_death_status_90days_cmp failcode=1 HRS_criteria_3 == 0

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	124
0		—	—
1		0.53	0.26, 1.06	0.072
age	124	0.98	0.95, 1.01	0.270
race_2	124
0		—	—
1		0.47	0.24, 0.92	0.028
hispanic	124
0		—	—
1		0.90	0.40, 2.04	0.810
admit_meld_3	124	1.04	0.99, 1.09	0.110
1 HR = Hazard Ratio, CI = Confidence Interval

added 3.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=1 HRS_criteria_3 == 0

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	124
0		—	—
1		0.51	0.25, 1.04	0.065
age	124	0.98	0.95, 1.01	0.2
race_2	124
0		—	—
1		0.43	0.21, 0.87	0.018
hispanic	124
0		—	—
1		0.65	0.29, 1.45	0.3
admit_meld_3	124	1.03	0.98, 1.08	0.2
1 HR = Hazard Ratio, CI = Confidence Interval

added 4.1 Unviariate cmp: time_to_death_status_90days_cmp failcode=2 listed_transplant == 1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.81	0.44, 1.52	0.520
age	141	1.00	0.98, 1.03	0.720
race_2	141
0		—	—
1		0.96	0.44, 2.09	0.910
hispanic	141
0		—	—
1		1.41	0.75, 2.68	0.290
admit_meld_3	141	1.00	0.97, 1.04	0.800
1 HR = Hazard Ratio, CI = Confidence Interval

added 4.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=2 listed_transplant == 1

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	141
0		—	—
1		0.84	0.44, 1.60	0.6
age	141	1.01	0.98, 1.04	0.5
race_2	141
0		—	—
1		1.06	0.47, 2.37	0.9
hispanic	141
0		—	—
1		1.53	0.74, 3.17	0.3
admit_meld_3	141	1.01	0.97, 1.04	0.8
1 HR = Hazard Ratio, CI = Confidence Interval

added 5.1 Unviariate cmp: time_to_death_status_90days_cmp failcode=2 listed_transplant == 0

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	102
0		—	—
1		0.88	0.08, 9.42	0.920
age	102	0.99	0.87, 1.12	0.880
race_2	102
0		—	—
1		0.29	0.03, 3.00	0.300
hispanic	102
0		—	—
1		0.00	0.00, 0.00	<0.001
admit_meld_3	102	1.20	1.04, 1.39	0.016
1 HR = Hazard Ratio, CI = Confidence Interval

added 5.1 Multiviariate cmp: time_to_death_status_90days_cmp failcode=2 listed_transplant == 0

Characteristic	N	HR1	95% CI1	p-value
HRS_reversal_new	102
0		—	—
1		3.05	0.23, 41.1	0.4
age	102	1.12	1.02, 1.23	0.017
race_2	102
0		—	—
1		0.32	0.07, 1.52	0.2
hispanic	102
0		—	—
1		0.00	0.00, 0.00	<0.001
admit_meld_3	102	1.44	1.19, 1.73	<0.001
1 HR = Hazard Ratio, CI = Confidence Interval

AE Discont_Day

ae_vars <- c(
  "any_ae",
  "terli_ae_abdpain",
  "terli_ae_nausea",
  "terli_ae_diarrhea",
  "terli_ae_volover",
  "terli_ae_brady",
  "terli_7",
  "terli_8",
  "terli_ae_respfail"
)

# Function to summarize median and IQR for each AE variable
summarize_ae <- function(var) {
  final_master %>% 
    group_by(.data[[var]]) %>%
    summarise(
      AE_Var = var,
      Group = as.character(.data[[var]][1]),
      Q1 = quantile(Discont_Day, probs = 0.25, na.rm = TRUE),
      Median = quantile(Discont_Day, probs = 0.5, na.rm = TRUE),
      Q3 = quantile(Discont_Day, probs = 0.75, na.rm = TRUE),
      .groups = "drop"
    )
}

# Apply to each variable and combine results
ae_summary <- map_dfr(ae_vars, summarize_ae) %>% select(AE_Var,Group,Q1,Median,Q3) %>% filter(Group==1)
ae_summary

## # A tibble: 9 × 5
##   AE_Var            Group    Q1 Median    Q3
##   <chr>             <chr> <dbl>  <dbl> <dbl>
## 1 any_ae            1         1      2  2.75
## 2 terli_ae_abdpain  1         1      1  2   
## 3 terli_ae_nausea   1         1      1  1   
## 4 terli_ae_diarrhea 1         1      1  1   
## 5 terli_ae_volover  1         2      3  4.25
## 6 terli_ae_brady    1         1      1  1.75
## 7 terli_7           1         1      2  4   
## 8 terli_8           1         1      1  2.5 
## 9 terli_ae_respfail 1         2      2  4