period 1 updated

Table 1

	0 (N=66)	1 (N=34)	Overall (N=100)
Gender
Female	29 (43.9%)	13 (38.2%)	42 (42.0%)
Male	37 (56.1%)	21 (61.8%)	58 (58.0%)
Age
Mean (SD)	68.7 (14.5)	72.1 (12.4)	69.8 (13.9)
Median [Q1,Q3]	71.0 [58.3,81.8]	74.0 [64.5,79.8]	72.5 [59.0,81.3]
Race_Group
White	31 (47.0%)	20 (58.8%)	51 (51.0%)
Asian	1 (1.5%)	6 (17.6%)	7 (7.0%)
Black	20 (30.3%)	6 (17.6%)	26 (26.0%)
Other	14 (21.2%)	2 (5.9%)	16 (16.0%)
LOS
Mean (SD)	11.2 (10.2)	10.9 (5.83)	11.1 (8.92)
Median [Q1,Q3]	8.00 [4.00,13.8]	9.50 [7.00,14.5]	9.00 [5.00,14.3]
HTN
N	2 (3.0%)	1 (2.9%)	3 (3.0%)
Y	64 (97.0%)	33 (97.1%)	97 (97.0%)
DM
N	13 (19.7%)	6 (17.6%)	19 (19.0%)
Y	53 (80.3%)	28 (82.4%)	81 (81.0%)
CAD
N	2 (3.0%)	4 (11.8%)	6 (6.0%)
Y	64 (97.0%)	30 (88.2%)	94 (94.0%)
Hgb
Mean (SD)	10.1 (1.72)	10.1 (1.34)	10.1 (1.59)
Median [Q1,Q3]	9.80 [8.88,11.1]	10.2 [9.23,10.9]	9.85 [9.10,11.0]
HCT_admit
Mean (SD)	31.5 (5.41)	31.9 (4.31)	31.6 (5.05)
Median [Q1,Q3]	30.9 [27.6,35.5]	32.2 [29.2,34.6]	31.2 [28.1,35.1]
HCT_discharge
Mean (SD)	30.1 (4.67)	29.8 (4.16)	30.0 (4.49)
Median [Q1,Q3]	29.9 [26.5,33.5]	29.8 [26.9,32.1]	29.9 [26.8,32.8]
Iron
Mean (SD)	56.1 (29.5)	46.1 (22.7)	52.5 (27.6)
Median [Q1,Q3]	48.0 [34.0,74.0]	44.0 [31.0,54.0]	46.0 [33.0,70.0]
Missing	7 (10.6%)	1 (2.9%)	8 (8.0%)
Ferritin
Mean (SD)	1150 (1570)	1100 (951)	1130 (1370)
Median [Q1,Q3]	768 [277,1490]	852 [458,1490]	834 [291,1490]
Missing	8 (12.1%)	1 (2.9%)	9 (9.0%)
TIBC
Mean (SD)	193 (79.5)	180 (66.9)	188 (74.8)
Median [Q1,Q3]	191 [149,230]	169 [140,189]	180 [142,218]
Missing	14 (21.2%)	2 (5.9%)	16 (16.0%)
NT_proBNP
Mean (SD)	46100 (52600)	26700 (19700)	38800 (44100)
Median [Q1,Q3]	24600 [8020,70000]	25900 [8850,38100]	25400 [7900,48800]
Missing	21 (31.8%)	7 (20.6%)	28 (28.0%)
troponin_T
Mean (SD)	0.241 (0.282)	0.770 (2.39)	0.432 (1.46)
Median [Q1,Q3]	0.140 [0.0600,0.320]	0.115 [0.0525,0.325]	0.130 [0.0600,0.330]
Missing	13 (19.7%)	4 (11.8%)	17 (17.0%)
UF_rate
Mean (SD)	39.3 (245)	9.20 (4.73)	29.0 (199)
Median [Q1,Q3]	8.74 [7.10,11.6]	8.66 [6.35,10.6]	8.72 [6.44,10.9]
EDW
Mean (SD)	77.7 (23.4)	73.0 (26.5)	76.1 (24.5)
Median [Q1,Q3]	74.2 [63.0,86.9]	67.7 [56.5,80.0]	72.0 [60.0,85.6]
admit_Weight
Mean (SD)	80.7 (24.4)	76.1 (26.6)	79.1 (25.1)
Median [Q1,Q3]	76.1 [65.1,88.6]	71.0 [59.9,82.3]	74.9 [62.9,87.4]
HF_score
Mean (SD)	2.26 (0.882)	2.18 (0.869)	2.23 (0.874)
Median [Q1,Q3]	3.00 [1.00,3.00]	2.00 [1.00,3.00]	3.00 [1.00,3.00]
Dialysis_Vintage
Mean (SD)	2.23 (2.06)	2.26 (2.02)	2.24 (2.04)
Median [Q1,Q3]	1.00 [1.00,3.00]	1.00 [1.00,3.00]	1.00 [1.00,3.00]
Access_type
AVF	25 (37.9%)	15 (44.1%)	40 (40.0%)
AVG	0 (0%)	4 (11.8%)	4 (4.0%)
TDC	41 (62.1%)	15 (44.1%)	56 (56.0%)
n_90
Mean (SD)	1.18 (0.975)	0.882 (1.01)	1.08 (0.992)
Median [Q1,Q3]	1.00 [0,2.00]	1.00 [0,1.75]	1.00 [0,2.00]
n_180
Mean (SD)	1.71 (1.43)	1.41 (1.28)	1.61 (1.38)
Median [Q1,Q3]	1.50 [1.00,3.00]	1.00 [0,2.75]	1.00 [0,3.00]

Balance check before

##  cobalt (Version 4.5.5, Build Date: 2024-04-02)

## Note: `s.d.denom` not specified; assuming "pooled".

## Balance Measures
##                     Type  M.0.Un SD.0.Un  M.1.Un SD.1.Un Diff.Un
## Age              Contin. 68.6667 14.5119 72.0588 12.3973  0.2513
## Race_Group_White  Binary  0.4697       .  0.5882       .  0.1185
## Race_Group_Asian  Binary  0.0152       .  0.1765       .  0.1613
## Race_Group_Black  Binary  0.3030       .  0.1765       . -0.1266
## Race_Group_Other  Binary  0.2121       .  0.0588       . -0.1533
## Gender_Male       Binary  0.5606       .  0.6176       .  0.0570
## CAD_Y             Binary  0.9697       .  0.8824       . -0.0873
## HTN_Y             Binary  0.9697       .  0.9706       .  0.0009
## DM_Y              Binary  0.8030       .  0.8235       .  0.0205
## HF_score         Contin.  2.2576  0.8825  2.1765  0.8694 -0.0926
## Dialysis_Vintage Contin.  2.2273  2.0591  2.2647  2.0197  0.0184
## Access_type_AVF   Binary  0.3788       .  0.4412       .  0.0624
## Access_type_AVG   Binary  0.0000       .  0.1176       .  0.1176
## Access_type_TDC   Binary  0.6212       .  0.4412       . -0.1800
## Location_HH       Binary  0.2879       .  0.2059       . -0.0820
## 
## Sample sizes
##     Control Treated
## All      66      34

Balance check after

## Note: `s.d.denom` not specified; assuming "pooled".

## Balance Measures
##                     Type M.0.Adj SD.0.Adj M.1.Adj SD.1.Adj Diff.Adj
## Age              Contin. 70.0927  13.9346 70.6503  15.0914   0.0413
## Race_Group_White  Binary  0.5343        .  0.5060        .  -0.0283
## Race_Group_Asian  Binary  0.0214        .  0.0964        .   0.0750
## Race_Group_Black  Binary  0.2731        .  0.3018        .   0.0287
## Race_Group_Other  Binary  0.1712        .  0.0958        .  -0.0754
## Gender_Male       Binary  0.5725        .  0.5653        .  -0.0072
## CAD_Y             Binary  0.9692        .  0.9137        .  -0.0555
## HTN_Y             Binary  0.9757        .  0.9864        .   0.0107
## DM_Y              Binary  0.7997        .  0.8110        .   0.0113
## HF_score         Contin.  2.2489   0.8747  2.2893   0.8479   0.0461
## Dialysis_Vintage Contin.  2.1894   1.9515  2.3583   2.0412   0.0828
## Access_type_AVF   Binary  0.4296        .  0.4249        .  -0.0047
## Access_type_AVG   Binary  0.0000        .  0.0979        .   0.0979
## Access_type_TDC   Binary  0.5704        .  0.4772        .  -0.0932
## Location_HH       Binary  0.2859        .  0.3312        .   0.0453
## 
## Effective sample sizes
##            Control Treated
## Unadjusted   66.     34.  
## Adjusted     61.38   23.66

Univariate linear regression outcome los

outcome los

Characteristic	N	Beta	95% CI1	p-value
group	185
BWH		—	—
MGH		-0.82	-4.5, 2.8	0.659
Age	185	-0.06	-0.19, 0.07	0.344
Gender	185
Female		—	—
Male		-0.45	-4.1, 3.2	0.809
Race_Group	185
White		—	—
Asian		-5.4	-13, 2.3	0.173
Black		-3.9	-8.0, 0.21	0.066
Other		-5.8	-11, -0.42	0.037
HTN	185
N		—	—
Y		1.8	-11, 15	0.789
DM	185
N		—	—
Y		2.8	-1.7, 7.4	0.224
CAD	185
N		—	—
Y		-2.6	-10, 5.1	0.508
Dialysis_Vintage	185	-0.68	-1.6, 0.23	0.145
HF_score	185	-0.42	-2.6, 1.7	0.699
weight.ATE	185	-0.54	-1.4, 0.32	0.219
1 CI = Confidence Interval

Multivariate linear regression los ： group+ Age+Gender+Race_Group

Multivariate linear regression los ： group+ Age+Gender+Race_Group+HTN+DM+CAD+Dialysis_Vintage+HF_score

90 days poisson regression group

Characteristic	N	IRR1	95% CI1	p-value
group
BWH	95	—	—
MGH	90	0.69	0.51, 0.93	0.016
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

90 days poisson regression group Age Gender Race_Group

Characteristic	N	IRR1	95% CI1	p-value
group
BWH	95	—	—
MGH	90	0.67	0.49, 0.91	0.012
Age	185	1.00	0.99, 1.02	0.558
Gender
Female	80	—	—
Male	105	0.91	0.67, 1.25	0.556
Race_Group
White	96	—	—
Asian	10	1.65	0.89, 2.84	0.089
Black	53	0.84	0.56, 1.24	0.389
Other	25	1.26	0.81, 1.92	0.281
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

90 days poisson regression： group+ Age+Gender+Race_Group+DM+CAD+Dialysis_Vintage+HF_score

Characteristic	N	IRR1	95% CI1	p-value
group
BWH	95	—	—
MGH	90	0.66	0.48, 0.91	0.013
Age	185	1.00	0.99, 1.01	0.807
Gender
Female	80	—	—
Male	105	0.72	0.51, 1.01	0.053
Race_Group
White	96	—	—
Asian	10	2.08	1.10, 3.67	0.016
Black	53	0.98	0.65, 1.47	0.925
Other	25	1.54	0.97, 2.39	0.060
DM
N	36	—	—
Y	149	1.88	1.22, 3.01	0.006
CAD
N	10	—	—
Y	175	1.14	0.55, 2.73	0.752
Dialysis_Vintage	185	0.85	0.76, 0.94	0.003
HF_score	185	1.21	1.00, 1.48	0.055
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days poisson regression group

Characteristic	N	IRR1	95% CI1	p-value
group
BWH	95	—	—
MGH	90	0.85	0.67, 1.08	0.190
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days poisson regression： Age Gender Race_Group

Characteristic	N	IRR1	95% CI1	p-value
group
BWH	95	—	—
MGH	90	0.87	0.68, 1.10	0.249
Age	185	1.00	0.99, 1.01	0.742
Gender
Female	80	—	—
Male	105	0.94	0.74, 1.21	0.634
Race_Group
White	96	—	—
Asian	10	1.28	0.74, 2.08	0.342
Black	53	1.09	0.80, 1.48	0.562
Other	25	1.60	1.14, 2.21	0.006
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days poisson regression： group+ Age+Gender+Race_Group+DM+CAD+Dialysis_Vintage+HF_score

Characteristic	N	IRR1	95% CI1	p-value
group
BWH	95	—	—
MGH	90	0.91	0.71, 1.16	0.442
Age	185	1.00	0.99, 1.01	0.741
Gender
Female	80	—	—
Male	105	0.78	0.59, 1.03	0.075
Race_Group
White	96	—	—
Asian	10	1.49	0.86, 2.45	0.131
Black	53	1.16	0.85, 1.58	0.350
Other	25	1.66	1.17, 2.32	0.004
DM
N	36	—	—
Y	149	1.55	1.10, 2.22	0.014
CAD
N	10	—	—
Y	175	2.99	1.33, 8.63	0.019
Dialysis_Vintage	185	0.84	0.77, 0.91	<0.001
HF_score	185	1.05	0.90, 1.22	0.526
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

Univariate coxph time to 1st_readmission 180

Characteristic	N	HR1	95% CI1	p-value
group	185
BWH		—	—
MGH		1.91	0.69, 5.33	0.215
Age	185	0.99	0.94, 1.03	0.505
Gender	185
Female		—	—
Male		2.40	0.76, 7.58	0.136
Race_Group	185
White		—	—
Asian		1.39	0.28, 6.98	0.686
Black		1.44	0.44, 4.67	0.543
Other		0.21	0.02, 1.79	0.153
HTN	185
N		—	—
Y		0.24	0.07, 0.82	0.022
DM	185
N		—	—
Y		0.92	0.26, 3.26	0.894
CAD	185
N		—	—
Y		0.58	0.16, 2.14	0.416
Dialysis_Vintage	185	1.23	1.04, 1.47	0.018
HF_score	185	1.11	0.58, 2.14	0.757
weight.ATE	185	1.17	0.95, 1.44	0.142
1 HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph time to 1st_readmission 180

Characteristic	HR1	95% CI1	p-value
group
BWH	—	—
MGH	1.81	0.68, 4.83	0.237
Age	0.99	0.96, 1.03	0.724
Gender
Female	—	—
Male	2.46	0.75, 8.07	0.136
Race_Group
White	—	—
Asian	1.10	0.20, 5.96	0.908
Black	1.59	0.53, 4.81	0.411
Other	0.26	0.03, 2.36	0.232
1 HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph time to 1st_readmission 180

Characteristic	HR1	95% CI1	p-value
group
BWH	—	—
MGH	1.98	0.61, 6.39	0.254
Age	1.00	0.95, 1.05	0.966
Gender
Female	—	—
Male	3.48	0.94, 12.8	0.061
Race_Group
White	—	—
Asian	0.82	0.16, 4.10	0.810
Black	0.85	0.20, 3.67	0.827
Other	0.22	0.02, 2.28	0.207
HTN
N	—	—
Y	0.38	0.07, 1.94	0.246
DM
N	—	—
Y	0.48	0.11, 2.06	0.324
CAD
N	—	—
Y	0.89	0.25, 3.18	0.857
Dialysis_Vintage	1.36	1.08, 1.71	0.010
HF_score	0.76	0.38, 1.50	0.425
1 HR = Hazard Ratio, CI = Confidence Interval