Characteristic
Unadjusted Hazard Ratio (95% CI)
Adjusted Hazard Ratio (95% CI)
Group HR1 95% CI1 p-value HR1 95% CI1 p-value
drug drug





    0 drug — —
— —
    1 drug 1.06 0.75, 1.50 0.7 1.12 0.78, 1.60 0.5
sex sex





    Female sex — —
— —
    Male sex 1.62 1.02, 2.58 0.041 1.71 1.06, 2.76 0.027
bil bil 1.16 1.13, 1.19 <0.001 1.16 1.13, 1.20 <0.001
histo histo





    1 histo — —
— —
    2 histo 4.99 0.66, 37.6 0.12 4.55 0.60, 34.6 0.14
    3 histo 8.58 1.18, 62.4 0.034 6.65 0.90, 49.0 0.063
    4 histo 21.4 2.96, 154 0.002 15.0 2.05, 110 0.008
ageyr ageyr





    < 45 yrs ageyr — —
— —
    45-55 yrs ageyr 1.87 1.17, 3.00 0.009 1.48 0.91, 2.40 0.11
    > 55 yrs ageyr 2.23 1.40, 3.56 <0.001 1.71 1.05, 2.78 0.030
1 HR = Hazard Ratio, CI = Confidence Interval