| Characteristic | N = 21,6021 |
|---|---|
| Cancer type | |
| Breast | 7,459 (35%) |
| Colorectal | 3,242 (15%) |
| Lung/Bronchus | 6,066 (28%) |
| Prostate | 4,835 (22%) |
| 1 n (%) | |
| Characteristic | Overall N = 21,6021 |
Breast N = 7,4591 |
Colorectal N = 3,2421 |
Lung/Bronchus N = 6,0661 |
Prostate N = 4,8351 |
|---|---|---|---|---|---|
| Surgery | |||||
| Yes | 12,671 (59%) | 6,935 (93%) | 2,634 (81%) | 1,590 (26%) | 1,512 (31%) |
| No | 7,669 (36%) | 354 (4.7%) | 487 (15%) | 3,702 (61%) | 3,126 (65%) |
| Too risky/patient died | 915 (4.2%) | 69 (0.9%) | 51 (1.6%) | 676 (11%) | 119 (2.5%) |
| Recommended, patient refused | 269 (1.2%) | 65 (0.9%) | 46 (1.4%) | 89 (1.5%) | 69 (1.4%) |
| Unknown | 78 (0.4%) | 36 (0.5%) | 24 (0.7%) | 9 (0.1%) | 9 (0.2%) |
| Chemotherapy | |||||
| Yes | 6,086 (28%) | 1,958 (26%) | 1,391 (43%) | 2,628 (43%) | 109 (2.3%) |
| No | 13,896 (64%) | 5,049 (68%) | 1,490 (46%) | 2,697 (44%) | 4,660 (96%) |
| Too risky/patient died | 596 (2.8%) | 89 (1.2%) | 143 (4.4%) | 340 (5.6%) | 24 (0.5%) |
| Recommended, patient refused | 855 (4.0%) | 299 (4.0%) | 158 (4.9%) | 364 (6.0%) | 34 (0.7%) |
| Unknown | 169 (0.8%) | 64 (0.9%) | 60 (1.9%) | 37 (0.6%) | 8 (0.2%) |
| Hormone therapy | |||||
| Yes | 6,872 (32%) | 4,971 (67%) | 2 (<0.1%) | 20 (0.3%) | 1,879 (39%) |
| No | 13,562 (63%) | 1,490 (20%) | 3,221 (99%) | 6,018 (99%) | 2,833 (59%) |
| Too risky/patient died | 84 (0.4%) | 63 (0.8%) | 1 (<0.1%) | 8 (0.1%) | 12 (0.2%) |
| Recommended, patient refused | 692 (3.2%) | 592 (7.9%) | 5 (0.2%) | 13 (0.2%) | 82 (1.7%) |
| Unknown | 392 (1.8%) | 343 (4.6%) | 13 (0.4%) | 7 (0.1%) | 29 (0.6%) |
| Radiation | |||||
| Yes | 8,800 (41%) | 3,811 (51%) | 651 (20%) | 2,587 (43%) | 1,751 (36%) |
| No | 11,386 (53%) | 2,941 (39%) | 2,488 (77%) | 3,079 (51%) | 2,878 (60%) |
| Too risky/patient died | 316 (1.5%) | 99 (1.3%) | 28 (0.9%) | 160 (2.6%) | 29 (0.6%) |
| Recommended, patient refused | 816 (3.8%) | 475 (6.4%) | 35 (1.1%) | 197 (3.2%) | 109 (2.3%) |
| Unknown | 284 (1.3%) | 133 (1.8%) | 40 (1.2%) | 43 (0.7%) | 68 (1.4%) |
| Immunotherapy | |||||
| Yes | 2,366 (11%) | 637 (8.5%) | 178 (5.5%) | 1,518 (25%) | 33 (0.7%) |
| No | 18,877 (87%) | 6,748 (90%) | 3,022 (93%) | 4,315 (71%) | 4,792 (99%) |
| Too risky/patient died | 125 (0.6%) | 8 (0.1%) | 16 (0.5%) | 99 (1.6%) | 2 (<0.1%) |
| Recommended, patient refused | 148 (0.7%) | 32 (0.4%) | 13 (0.4%) | 101 (1.7%) | 2 (<0.1%) |
| Unknown | 86 (0.4%) | 34 (0.5%) | 13 (0.4%) | 33 (0.5%) | 6 (0.1%) |
| 1 n (%) | |||||
| Table before excluding patients who died/treatment too risky | N = 21,6021 |
|---|---|
| Cancer type | |
| Breast | 7,459 (35%) |
| Colorectal | 3,242 (15%) |
| Lung/Bronchus | 6,066 (28%) |
| Prostate | 4,835 (22%) |
| 1 n (%) | |
| Table after excluding patients who died/treatment too risky | N = 19,9601 |
|---|---|
| Cancer type | |
| Breast | 7,200 (36%) |
| Colorectal | 3,057 (15%) |
| Lung/Bronchus | 5,032 (25%) |
| Prostate | 4,671 (23%) |
| 1 n (%) | |
| Characteristic | Overall N = 19,9471 |
2017 N = 3,8201 |
2018 N = 3,7781 |
2019 N = 4,1181 |
2020 N = 3,8751 |
2021 N = 4,3561 |
|---|---|---|---|---|---|---|
| Cancer type | ||||||
| Breast | 7,194 (36%) | 1,400 (37%) | 1,336 (35%) | 1,468 (36%) | 1,345 (35%) | 1,645 (38%) |
| Colorectal | 3,054 (15%) | 606 (16%) | 579 (15%) | 641 (16%) | 587 (15%) | 641 (15%) |
| Lung/Bronchus | 5,031 (25%) | 961 (25%) | 971 (26%) | 1,033 (25%) | 1,061 (27%) | 1,005 (23%) |
| Prostate | 4,668 (23%) | 853 (22%) | 892 (24%) | 976 (24%) | 882 (23%) | 1,065 (24%) |
| Age at diagnosis | 67 (12) | 67 (12) | 67 (12) | 67 (12) | 67 (11) | 67 (12) |
| Age Group (at dx) | ||||||
| Age <= 49 | 1,646 (8.3%) | 316 (8.3%) | 333 (8.8%) | 329 (8.0%) | 298 (7.7%) | 370 (8.5%) |
| Age 50-64 | 6,480 (32%) | 1,297 (34%) | 1,232 (33%) | 1,367 (33%) | 1,220 (31%) | 1,364 (31%) |
| Age 65-74 | 7,237 (36%) | 1,357 (36%) | 1,342 (36%) | 1,467 (36%) | 1,444 (37%) | 1,627 (37%) |
| Age 75+ | 4,584 (23%) | 850 (22%) | 871 (23%) | 955 (23%) | 913 (24%) | 995 (23%) |
| Sex | ||||||
| Female | 11,264 (56%) | 2,213 (58%) | 2,105 (56%) | 2,322 (56%) | 2,172 (56%) | 2,452 (56%) |
| Male | 8,683 (44%) | 1,607 (42%) | 1,673 (44%) | 1,796 (44%) | 1,703 (44%) | 1,904 (44%) |
| White | ||||||
| White | 19,569 (98%) | 3,745 (98%) | 3,706 (98%) | 4,040 (98%) | 3,817 (99%) | 4,261 (98%) |
| Other | 310 (1.6%) | 67 (1.8%) | 60 (1.6%) | 71 (1.7%) | 41 (1.1%) | 71 (1.6%) |
| Unknown | 68 (0.3%) | 8 (0.2%) | 12 (0.3%) | 7 (0.2%) | 17 (0.4%) | 24 (0.6%) |
| Insurance | ||||||
| Commercial | 6,521 (33%) | 1,310 (34%) | 1,242 (33%) | 1,338 (32%) | 1,240 (32%) | 1,391 (32%) |
| Medicare | 9,016 (45%) | 1,694 (44%) | 1,709 (45%) | 1,814 (44%) | 1,752 (45%) | 2,047 (47%) |
| Medicaid | 1,256 (6.3%) | 207 (5.4%) | 211 (5.6%) | 283 (6.9%) | 272 (7.0%) | 283 (6.5%) |
| Medicare/Medicaid | 1,848 (9.3%) | 365 (9.6%) | 341 (9.0%) | 396 (9.6%) | 358 (9.2%) | 388 (8.9%) |
| Veterans/public health service | 777 (3.9%) | 128 (3.4%) | 149 (3.9%) | 153 (3.7%) | 178 (4.6%) | 169 (3.9%) |
| Not insured | 268 (1.3%) | 68 (1.8%) | 69 (1.8%) | 65 (1.6%) | 31 (0.8%) | 35 (0.8%) |
| Unknown | 261 (1.3%) | 48 (1.3%) | 57 (1.5%) | 69 (1.7%) | 44 (1.1%) | 43 (1.0%) |
| Rural Classification | ||||||
| Urban | 9,947 (50%) | 1,916 (50%) | 1,906 (50%) | 2,032 (49%) | 1,926 (50%) | 2,167 (50%) |
| Large rural | 3,423 (17%) | 574 (15%) | 584 (15%) | 738 (18%) | 743 (19%) | 784 (18%) |
| Small rural | 2,511 (13%) | 493 (13%) | 490 (13%) | 533 (13%) | 472 (12%) | 523 (12%) |
| Isolated rural | 4,066 (20%) | 837 (22%) | 798 (21%) | 815 (20%) | 734 (19%) | 882 (20%) |
| ADI Quintile | ||||||
| ADI_Q1 | 3,278 (16%) | 599 (16%) | 662 (18%) | 656 (16%) | 616 (16%) | 745 (17%) |
| ADI_Q2 | 4,084 (20%) | 804 (21%) | 759 (20%) | 802 (19%) | 821 (21%) | 898 (21%) |
| ADI_Q3 | 4,262 (21%) | 774 (20%) | 792 (21%) | 960 (23%) | 833 (21%) | 903 (21%) |
| ADI_Q4 | 4,615 (23%) | 902 (24%) | 839 (22%) | 957 (23%) | 906 (23%) | 1,011 (23%) |
| ADI_Q5 | 3,375 (17%) | 666 (17%) | 669 (18%) | 685 (17%) | 636 (16%) | 719 (17%) |
| Unknown | 333 (1.7%) | 75 (2.0%) | 57 (1.5%) | 58 (1.4%) | 63 (1.6%) | 80 (1.8%) |
| Stage | ||||||
| In situ | 1,313 (6.6%) | 272 (7.1%) | 229 (6.1%) | 265 (6.4%) | 217 (5.6%) | 330 (7.6%) |
| Localized | 10,454 (52%) | 1,946 (51%) | 2,014 (53%) | 2,098 (51%) | 2,027 (52%) | 2,369 (54%) |
| Regional | 4,692 (24%) | 933 (24%) | 872 (23%) | 1,038 (25%) | 918 (24%) | 931 (21%) |
| Distant | 3,488 (17%) | 669 (18%) | 663 (18%) | 717 (17%) | 713 (18%) | 726 (17%) |
| 1 n (%); Median (SD) | ||||||
| Characteristic |
RUCA Measure
|
ADI
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Urban N = 2,8731 |
Large rural N = 9371 |
Small rural N = 6081 |
Isolated rural N = 1,0671 |
p-value2 | ADI_Q1 N = 1,0191 |
ADI_Q2 N = 1,2751 |
ADI_Q3 N = 1,1321 |
ADI_Q4 N = 1,1241 |
ADI_Q5 N = 8401 |
p-value2 | |
| Localized or Regional | |||||||||||
| Surgical Resection | 2,793 (100%) | 919 (100%) | 592 (100%) | 1,048 (100%) | 0.3 | 995 (100%) | 1,243 (100%) | 1,114 (100%) | 1,086 (100%) | 822 (100%) | 0.6 |
| Chemotherapy | 483 (17%) | 157 (17%) | 102 (17%) | 144 (14%) | 0.087 | 168 (17%) | 232 (18%) | 197 (17%) | 158 (14%) | 113 (14%) | 0.017 |
| Radiation | 1,408 (50%) | 471 (50%) | 269 (46%) | 487 (46%) | 0.12 | 494 (49%) | 648 (51%) | 561 (50%) | 538 (48%) | 348 (43%) | 0.005 |
| Hormone therapy | 1,873 (68%) | 652 (71%) | 373 (67%) | 700 (69%) | 0.3 | 657 (66%) | 842 (68%) | 748 (69%) | 774 (72%) | 508 (66%) | 0.021 |
| Immunotherapy | 176 (6.1%) | 76 (8.1%) | 35 (5.9%) | 59 (5.5%) | 0.087 | 72 (7.1%) | 93 (7.3%) | 79 (7.0%) | 56 (5.0%) | 39 (4.7%) | 0.027 |
| Time to treatment (days) | 39 (30) | 38 (27) | 32 (35) | 37 (32) | <0.001 | 40 (30) | 38 (31) | 38 (29) | 38 (30) | 34 (31) | <0.001 |
| Distant (Advanced Stage) | |||||||||||
| Surgical Resection | 689 (100%) | 273 (100%) | 164 (100%) | 272 (100%) | 0.5 | 244 (100%) | 311 (100%) | 293 (100%) | 306 (100%) | 219 (100%) | 0.6 |
| Chemotherapy | 525 (62%) | 201 (64%) | 110 (55%) | 192 (59%) | 0.2 | 185 (64%) | 239 (63%) | 222 (64%) | 202 (54%) | 159 (58%) | 0.025 |
| Radiation | 583 (70%) | 215 (71%) | 117 (59%) | 212 (67%) | 0.023 | 215 (76%) | 266 (72%) | 242 (71%) | 226 (62%) | 156 (60%) | <0.001 |
| Hormone therapy | 614 (75%) | 226 (75%) | 153 (82%) | 244 (79%) | 0.2 | 232 (82%) | 277 (76%) | 259 (77%) | 257 (73%) | 191 (77%) | 0.12 |
| Immunotherapy | 157 (18%) | 63 (20%) | 17 (8.5%) | 43 (13%) | <0.001 | 50 (17%) | 75 (20%) | 63 (18%) | 48 (13%) | 38 (14%) | 0.075 |
| Time to treatment (days) | 29 (37) | 32 (29) | 33 (34) | 31 (36) | 0.3 | 32 (37) | 28 (34) | 29 (35) | 32 (34) | 33 (34) | 0.3 |
| 1 n (%); Median (IQR) | |||||||||||
| 2 Fisher’s exact test; Pearson’s Chi-squared test; Kruskal-Wallis rank sum test | |||||||||||
| Characteristic |
RUCA Measure
|
ADI
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Urban N = 6341 |
Large rural N = 2221 |
Small rural N = 1821 |
Isolated rural N = 2361 |
p-value2 | ADI_Q1 N = 1851 |
ADI_Q2 N = 2551 |
ADI_Q3 N = 2921 |
ADI_Q4 N = 3081 |
ADI_Q5 N = 2141 |
p-value2 | |
| Localized or Regional | |||||||||||
| Surgical Resection | 564 (99%) | 216 (100%) | 164 (99%) | 215 (99%) | 0.4 | 165 (99%) | 232 (100%) | 272 (100%) | 283 (99%) | 188 (98%) | 0.071 |
| Chemotherapy | 101 (16%) | 27 (12%) | 19 (11%) | 24 (10%) | 0.070 | 26 (14%) | 37 (15%) | 42 (14%) | 40 (13%) | 23 (11%) | 0.8 |
| Radiation | 83 (13%) | 23 (10%) | 18 (10%) | 27 (11%) | 0.6 | 17 (9.2%) | 35 (14%) | 41 (14%) | 37 (12%) | 20 (9.6%) | 0.3 |
| Hormone therapy | |||||||||||
| No | 630 (100%) | 222 (100%) | 181 (100%) | 235 (100%) | 185 (100%) | 254 (100%) | 292 (100%) | 306 (100%) | 211 (100%) | ||
| Immunotherapy | 3 (0.5%) | 0 (0%) | 0 (0%) | 0 (0%) | 0.7 | 0 (0%) | 2 (0.8%) | 0 (0%) | 1 (0.3%) | 0 (0%) | 0.3 |
| Time to treatment (days) | 1 (34) | 0 (24) | 0 (25) | 4 (35) | 0.016 | 0 (30) | 0 (31) | 2 (29) | 0 (35) | 4 (29) | 0.8 |
| Distant (Advanced Stage) | |||||||||||
| Surgical Resection | 638 (100%) | 259 (100%) | 192 (100%) | 265 (100%) | 0.9 | 207 (100%) | 263 (100%) | 295 (100%) | 333 (100%) | 234 (100%) | 0.9 |
| Chemotherapy | 537 (66%) | 220 (68%) | 169 (71%) | 261 (71%) | 0.3 | 164 (63%) | 241 (71%) | 268 (71%) | 292 (68%) | 207 (68%) | 0.2 |
| Radiation | 218 (27%) | 106 (32%) | 53 (22%) | 100 (27%) | 0.057 | 71 (27%) | 96 (28%) | 112 (29%) | 122 (28%) | 71 (23%) | 0.4 |
| Hormone therapy | 2 (0.2%) | 0 (0%) | 0 (0%) | 0 (0%) | >0.9 | 0 (0%) | 1 (0.3%) | 0 (0%) | 1 (0.2%) | 0 (0%) | 0.9 |
| Immunotherapy | 72 (8.7%) | 32 (9.8%) | 28 (11%) | 36 (9.6%) | 0.7 | 25 (9.3%) | 27 (7.8%) | 35 (9.2%) | 47 (11%) | 33 (11%) | 0.7 |
| Time to treatment (days) | 20 (36) | 23 (36) | 18 (35) | 26 (40) | 0.042 | 20 (37) | 21 (37) | 20 (34) | 24 (39) | 21 (39) | 0.9 |
| 1 n (%); Median (IQR) | |||||||||||
| 2 Fisher’s exact test; Pearson’s Chi-squared test; Kruskal-Wallis rank sum test | |||||||||||
| Characteristic |
RUCA Measure
|
ADI
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Urban N = 7791 |
Large rural N = 2581 |
Small rural N = 1881 |
Isolated rural N = 2861 |
p-value2 | ADI_Q1 N = 1941 |
ADI_Q2 N = 2561 |
ADI_Q3 N = 3381 |
ADI_Q4 N = 3891 |
ADI_Q5 N = 3071 |
p-value2 | |
| Localized or Regional | |||||||||||
| Surgical Resection | 445 (100%) | 161 (100%) | 113 (100%) | 180 (99%) | 0.8 | 123 (100%) | 159 (100%) | 201 (100%) | 215 (99%) | 187 (100%) | 0.3 |
| Chemotherapy | 71 (9.1%) | 27 (10%) | 21 (11%) | 17 (6.0%) | 0.2 | 21 (11%) | 23 (9.0%) | 28 (8.3%) | 37 (9.5%) | 25 (8.1%) | 0.8 |
| Radiation | 260 (34%) | 72 (28%) | 54 (29%) | 82 (29%) | 0.2 | 61 (31%) | 79 (31%) | 106 (32%) | 126 (33%) | 88 (29%) | 0.9 |
| Hormone therapy | 1 (0.1%) | 1 (0.4%) | 0 (0%) | 0 (0%) | 0.5 | 1 (0.5%) | 0 (0%) | 1 (0.3%) | 0 (0%) | 0 (0%) | 0.3 |
| Immunotherapy | 16 (2.1%) | 6 (2.3%) | 9 (4.8%) | 6 (2.1%) | 0.2 | 5 (2.6%) | 4 (1.6%) | 7 (2.1%) | 9 (2.3%) | 12 (3.9%) | 0.5 |
| Time to treatment (days) | 48 (59) | 32 (56) | 48 (66) | 42 (59) | <0.001 | 46 (58) | 42 (56) | 40 (54) | 39 (68) | 50 (58) | 0.2 |
| Distant (Advanced Stage) | |||||||||||
| Surgical Resection | 285 (99%) | 113 (98%) | 94 (98%) | 147 (98%) | >0.9 | 69 (97%) | 96 (99%) | 149 (99%) | 168 (99%) | 147 (97%) | 0.5 |
| Chemotherapy | 1,104 (63%) | 363 (65%) | 265 (56%) | 429 (60%) | 0.005 | 313 (67%) | 425 (66%) | 487 (63%) | 500 (57%) | 408 (60%) | <0.001 |
| Radiation | 792 (46%) | 256 (46%) | 193 (41%) | 268 (37%) | <0.001 | 210 (45%) | 289 (45%) | 329 (43%) | 385 (44%) | 282 (42%) | 0.8 |
| Hormone therapy | 9 (0.5%) | 0 (0%) | 4 (0.8%) | 4 (0.6%) | 0.2 | 1 (0.2%) | 3 (0.5%) | 3 (0.4%) | 4 (0.4%) | 6 (0.9%) | 0.6 |
| Immunotherapy | 693 (40%) | 227 (41%) | 150 (31%) | 245 (34%) | <0.001 | 200 (42%) | 295 (46%) | 285 (37%) | 302 (34%) | 219 (32%) | <0.001 |
| Time to treatment (days) | 24 (38) | 25 (36) | 22 (43) | 27 (43) | 0.14 | 26 (34) | 24 (41) | 22 (36) | 25 (41) | 26 (43) | 0.062 |
| 1 n (%); Median (IQR) | |||||||||||
| 2 Fisher’s exact test; Pearson’s Chi-squared test; Kruskal-Wallis rank sum test | |||||||||||
| Characteristic |
RUCA Measure
|
ADI
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Urban N = 1,6921 |
Large rural N = 6101 |
Small rural N = 4471 |
Isolated rural N = 7481 |
p-value2 | ADI_Q1 N = 6381 |
ADI_Q2 N = 6941 |
ADI_Q3 N = 7521 |
ADI_Q4 N = 8291 |
ADI_Q5 N = 5181 |
p-value2 | |
| Localized or Regional | |||||||||||
| Surgical Resection | 491 (99%) | 174 (98%) | 130 (94%) | 201 (96%) | 0.022 | 173 (98%) | 172 (96%) | 219 (96%) | 253 (98%) | 156 (99%) | 0.4 |
| Chemotherapy | 3 (0.2%) | 2 (0.3%) | 0 (0%) | 1 (0.1%) | 0.8 | 1 (0.2%) | 2 (0.3%) | 1 (0.1%) | 1 (0.1%) | 1 (0.2%) | >0.9 |
| Radiation | 637 (38%) | 232 (38%) | 164 (37%) | 248 (34%) | 0.2 | 264 (42%) | 283 (41%) | 270 (36%) | 256 (31%) | 190 (37%) | <0.001 |
| Hormone therapy | 476 (28%) | 166 (27%) | 145 (33%) | 206 (28%) | 0.2 | 187 (29%) | 197 (29%) | 190 (25%) | 230 (28%) | 171 (33%) | 0.048 |
| Immunotherapy | 1 (<0.1%) | 0 (0%) | 0 (0%) | 2 (0.3%) | 0.3 | 0 (0%) | 0 (0%) | 2 (0.3%) | 1 (0.1%) | 0 (0%) | 0.5 |
| Time to treatment (days) | 49 (71) | 55 (76) | 48 (76) | 38 (69) | <0.001 | 53 (65) | 48 (67) | 49 (77) | 42 (73) | 49 (72) | 0.057 |
| Distant (Advanced Stage) | |||||||||||
| Surgical Resection | 215 (100%) | 89 (99%) | 55 (100%) | 118 (100%) | 0.3 | 85 (100%) | 95 (100%) | 107 (99%) | 103 (100%) | 72 (100%) | >0.9 |
| Chemotherapy | 47 (8.9%) | 14 (7.1%) | 17 (12%) | 22 (7.5%) | 0.4 | 18 (8.7%) | 16 (6.9%) | 15 (6.3%) | 29 (11%) | 20 (9.7%) | 0.3 |
| Radiation | 170 (33%) | 74 (38%) | 43 (30%) | 90 (31%) | 0.3 | 64 (32%) | 80 (35%) | 79 (33%) | 81 (32%) | 65 (32%) | >0.9 |
| Hormone therapy | 347 (66%) | 125 (64%) | 105 (71%) | 202 (69%) | 0.4 | 129 (64%) | 160 (70%) | 156 (65%) | 168 (66%) | 149 (73%) | 0.2 |
| Immunotherapy | 9 (1.7%) | 9 (4.6%) | 6 (4.1%) | 4 (1.4%) | 0.044 | 2 (1.0%) | 3 (1.3%) | 9 (3.8%) | 7 (2.7%) | 7 (3.4%) | 0.2 |
| Time to treatment (days) | 43 (74) | 44 (54) | 33 (55) | 47 (80) | 0.2 | 45 (74) | 42 (76) | 44 (65) | 42 (71) | 41 (67) | 0.9 |
| 1 n (%); Median (IQR) | |||||||||||
| 2 Fisher’s exact test; Pearson’s Chi-squared test; Kruskal-Wallis rank sum test | |||||||||||