Summary of Liver Risk Categories
Characteristic Liver Risk Score Categories p-value2
<61 6-101 10-151 >151
Demographic Parameters
Congestion_Score_Cat



0.165
    0 37 (18%) 109 (16%) 26 (16%) 4 (15%)
    1 169 (81%) 557 (80%) 127 (77%) 22 (81%)
    2 3 (1.4%) 34 (4.9%) 13 (7.8%) 1 (3.7%)
gender



0.000
    male 96 (46%) 515 (74%) 129 (78%) 26 (96%)
    female 113 (54%) 185 (26%) 37 (22%) 1 (3.7%)
Age 72 (63, 80) 75 (67, 82) 74 (66, 81) 71 (63, 82) 0.010
PE_HGT 165 (158, 172) 170 (163, 178) 170 (165, 176) 175 (171, 179) 0.000
PE_WGT 76 (63, 90) 81 (70, 92) 83 (72, 92) 82 (71, 94) 0.000
BMI 27.0 (23.6, 31.2) 27.8 (24.8, 31.6) 28.4 (24.7, 33.1) 26.5 (22.9, 29.9) 0.088
SBP 122 (111, 140) 124 (110, 140) 127 (113, 138) 112 (105, 139) 0.542
DBP 71 (60, 80) 70 (63, 80) 69 (60, 80) 70 (65, 77) 0.265
was the EQ5D performed (Visit 1 (1)) 207 (99%) 695 (99%) 163 (98%) 27 (100%) 0.363
Healthcare Utilization & Outcomes
M 31 (15%) 190 (27%) 70 (42%) 16 (59%) <0.001
MH



<0.001
    0 156 (75%) 416 (59%) 81 (49%) 9 (33%)
    1 53 (25%) 284 (41%) 85 (51%) 18 (67%)
Mdays 690 (473, 914) 639 (424, 900) 539 (319, 840) 569 (132, 775) 0.001
Hdays 645 (429, 865) 542 (292, 811) 471 (205, 780) 416 (34, 708) <0.001
MHdays 645 (429, 865) 542 (292, 811) 471 (205, 780) 416 (34, 708) <0.001
MORT1Y 0.99 (0.95, 0.99) 0.98 (0.93, 0.99) 0.97 (0.90, 0.99) 0.96 (0.87, 0.98) <0.001
MORT2Y 0.97 (0.91, 0.99) 0.96 (0.88, 0.98) 0.94 (0.83, 0.98) 0.92 (0.78, 0.96) <0.001
HOSP1Y 0.90 (0.83, 0.93) 0.84 (0.77, 0.89) 0.79 (0.69, 0.86) 0.78 (0.62, 0.86) <0.001
HOSP2Y 0.85 (0.76, 0.89) 0.77 (0.67, 0.84) 0.70 (0.58, 0.80) 0.69 (0.49, 0.80) <0.001
SBP 122 (111, 140) 124 (110, 140) 127 (113, 138) 112 (105, 139) 0.5
DBP 71 (60, 80) 70 (63, 80) 69 (60, 80) 70 (65, 77) 0.3
Lifestyle & Risk Factors
TOTAL_BILIRUBIN 9 (7, 12) 11 (8, 17) 14 (9, 20) 16 (13, 33) 0.000
ALBUMINE 38 (34, 42) 37 (32, 41) 36 (30, 40) 31 (28, 36) 0.000
HDL_CHOLESTEROL 1.27 (1.05, 1.54) 1.08 (0.88, 1.31) 0.98 (0.83, 1.26) 1.06 (0.85, 1.51) 0.000
LDL_CHOLESTEROL 2.70 (2.04, 3.55) 2.02 (1.58, 2.57) 1.68 (1.21, 2.34) 1.90 (1.61, 2.31) 0.000
jugular venous pressure assessed (Visit 1 (1)) 172 (82%) 589 (84%) 135 (81%) 23 (85%) 0.779
Orthopnoea present (Visit 1 (1)) 18 (8.6%) 61 (8.7%) 25 (15%) 3 (11%) 0.092
GLUCOSE 5.10 (4.70, 5.61) 6.30 (5.40, 7.73) 9.94 (6.85, 14.08) 10.30 (7.10, 15.85) 0.000
GAMMA_GT 26 (18, 35) 46 (29, 80) 137 (66, 251) 338 (158, 570) 0.000
IRON 13 (9, 17) 12 (7, 16) 11 (7, 15) 9 (5, 12) 0.003
FERRITIN 96 (43, 185) 130 (55, 259) 96 (53, 232) 172 (92, 369) 0.004
HEMOGLOBIN 13.20 (12.20, 14.40) 13.39 (12.00, 14.66) 13.00 (11.50, 14.30) 12.75 (11.68, 13.65) 0.218
sex



0.000
    Male 96 (46%) 515 (74%) 129 (78%) 26 (96%)
    Female 113 (54%) 185 (26%) 37 (22%) 1 (3.7%)
PE_HGT 165 (158, 172) 170 (163, 178) 170 (165, 176) 175 (171, 179) 0.000
PE_WGT 76 (63, 90) 81 (70, 92) 83 (72, 92) 82 (71, 94) 0.000
IL6 4.4 (3.6, 5.2) 5.1 (4.1, 6.2) 5.6 (4.8, 7.0) 6.7 (5.6, 8.2) 0.000
BMP_6 5.62 (5.24, 5.91) 5.86 (5.49, 6.29) 6.10 (5.80, 6.41) 6.16 (5.77, 6.54) 0.000
ANGPT1 7.29 (6.64, 8.40) 7.15 (6.45, 8.01) 7.06 (6.54, 8.01) 6.80 (6.25, 7.63) 0.030
ADM 7.91 (7.51, 8.30) 8.17 (7.78, 8.55) 8.37 (8.07, 8.68) 8.67 (8.15, 8.90) 0.000
CD40_L 4.29 (3.78, 5.40) 4.18 (3.62, 5.00) 4.19 (3.60, 4.87) 3.80 (3.47, 4.61) 0.028
PGF 8.66 (8.37, 8.92) 8.88 (8.55, 9.22) 8.93 (8.64, 9.22) 9.01 (8.66, 9.35) 0.000
ADAM_TS13 6.37 (6.25, 6.49) 6.34 (6.21, 6.46) 6.34 (6.18, 6.44) 6.33 (6.25, 6.50) 0.248
BOC 4.53 (4.33, 4.74) 4.63 (4.41, 4.82) 4.74 (4.53, 4.99) 4.76 (4.47, 5.34) 0.000
IL_4RA 3.03 (2.81, 3.31) 3.29 (2.99, 3.66) 3.62 (3.26, 4.10) 4.21 (3.60, 5.12) 0.000
SRC 6.91 (6.10, 7.67) 6.69 (5.81, 7.50) 6.61 (5.73, 7.51) 6.02 (5.45, 6.54) 0.000
IL_1ra 5.13 (4.78, 5.74) 5.31 (4.89, 5.95) 5.67 (5.07, 6.23) 6.31 (5.63, 6.73) 0.000
TNFRSF10A 4.67 (4.31, 4.98) 4.84 (4.54, 5.19) 5.07 (4.79, 5.35) 5.28 (5.01, 5.65) 0.000
STK4 4.12 (3.37, 5.15) 4.06 (3.32, 5.03) 4.00 (3.21, 4.92) 3.69 (3.13, 4.22) 0.092
IDUA 6.19 (5.85, 6.47) 6.21 (5.92, 6.55) 6.36 (6.01, 6.68) 6.10 (6.01, 6.50) 0.013
TNFRSF11A 6.64 (6.13, 7.03) 6.81 (6.40, 7.42) 7.15 (6.75, 7.51) 7.42 (7.11, 7.79) 0.000
PAR_1 9.46 (9.09, 9.86) 9.59 (9.22, 9.94) 9.68 (9.39, 9.96) 9.74 (9.31, 10.15) 0.001
TRAIL_R2 6.92 (6.58, 7.25) 7.19 (6.79, 7.66) 7.41 (7.12, 7.81) 8.00 (7.52, 8.56) 0.000
PRSS27 8.96 (8.68, 9.34) 8.91 (8.54, 9.29) 8.99 (8.73, 9.42) 9.25 (8.66, 9.41) 0.016
TIE2 8.02 (7.85, 8.20) 8.11 (7.94, 8.31) 8.24 (8.05, 8.43) 8.23 (8.10, 8.48) 0.000
TF 6.02 (5.75, 6.29) 6.09 (5.83, 6.33) 6.15 (5.94, 6.38) 6.31 (5.90, 6.53) 0.001
IL1RL2 5.29 (4.98, 5.55) 5.27 (4.98, 5.56) 5.39 (5.12, 5.71) 5.47 (5.32, 5.74) 0.001
IL_27 6.78 (6.50, 7.06) 6.97 (6.70, 7.32) 7.15 (6.77, 7.46) 7.60 (7.17, 7.97) 0.000
IL_17D 3.45 (3.25, 3.70) 3.48 (3.26, 3.72) 3.49 (3.28, 3.73) 3.45 (3.37, 3.67) 0.660
CXCL1 8.61 (7.85, 9.50) 8.57 (7.94, 9.38) 8.69 (8.04, 9.54) 8.92 (8.40, 9.51) 0.333
LOX_1 7.35 (6.88, 7.68) 7.35 (7.00, 7.77) 7.48 (7.12, 7.82) 7.73 (7.16, 8.07) 0.006
Gal_9 8.76 (8.48, 8.98) 8.87 (8.62, 9.15) 8.94 (8.75, 9.16) 9.08 (8.87, 9.28) 0.000
GIF 8.64 (7.99, 9.16) 8.63 (7.88, 9.44) 8.89 (8.14, 9.74) 8.14 (7.35, 9.00) 0.005
SCF 9.27 (8.98, 9.47) 9.11 (8.71, 9.43) 8.98 (8.39, 9.30) 7.88 (7.56, 8.81) 0.000
IL18 8.97 (8.55, 9.32) 9.16 (8.74, 9.56) 9.28 (8.93, 9.66) 9.34 (8.93, 10.00) 0.000
FGF_21 8.32 (7.34, 9.32) 8.63 (7.63, 9.71) 9.28 (8.30, 10.33) 10.62 (8.43, 11.98) 0.000
PIgR 7.12 (7.05, 7.23) 7.15 (7.07, 7.23) 7.14 (7.06, 7.24) 7.12 (7.08, 7.21) 0.211
RAGE 14.03 (13.61, 14.37) 14.19 (13.78, 14.57) 14.27 (13.80, 14.63) 14.29 (13.78, 14.88) 0.000
SOD2 10.02 (9.93, 10.08) 10.02 (9.95, 10.09) 10.06 (10.00, 10.12) 10.08 (9.94, 10.13) 0.000
CTRC 10.42 (9.81, 10.98) 10.45 (9.82, 10.97) 10.33 (9.73, 11.11) 10.48 (9.78, 11.00) 0.983
FGF_23 5.93 (5.31, 6.67) 6.24 (5.56, 7.48) 6.74 (5.83, 8.07) 7.25 (6.26, 9.23) 0.000
SPON2 8.92 (8.77, 9.05) 9.01 (8.87, 9.12) 9.10 (9.00, 9.20) 9.18 (9.12, 9.23) 0.000
GH 8.78 (7.28, 10.14) 8.93 (7.56, 10.35) 9.15 (7.88, 10.39) 9.53 (7.91, 11.12) 0.051
FS 11.89 (11.54, 12.24) 11.98 (11.61, 12.35) 12.22 (11.92, 12.58) 12.40 (11.86, 13.17) 0.000
GLO1 5.12 (4.55, 5.64) 5.23 (4.78, 5.69) 5.32 (4.97, 5.76) 5.98 (5.24, 6.36) 0.000
CD84 5.02 (4.70, 5.37) 5.02 (4.75, 5.29) 5.07 (4.84, 5.27) 5.18 (4.98, 5.43) 0.273
PAPPA 4.05 (3.66, 4.43) 4.24 (3.86, 4.64) 4.42 (3.91, 4.77) 4.55 (4.05, 4.86) 0.000
SERPINA12 3.12 (2.58, 3.76) 3.24 (2.71, 4.01) 3.28 (2.83, 3.92) 3.48 (2.72, 3.94) 0.206
REN 8.24 (7.54, 8.92) 8.53 (7.83, 9.12) 8.81 (8.09, 9.40) 9.16 (8.48, 9.48) 0.000
DECR1 5.21 (4.53, 6.23) 5.37 (4.63, 6.27) 5.47 (5.05, 6.20) 5.63 (5.51, 6.69) 0.013
MERTK 6.88 (6.53, 7.12) 6.96 (6.66, 7.28) 7.14 (6.80, 7.46) 7.44 (7.28, 7.77) 0.000
KIM1 7.96 (7.46, 8.70) 8.36 (7.78, 8.95) 8.82 (8.24, 9.41) 9.25 (8.81, 10.10) 0.000
THBS2 6.18 (6.03, 6.35) 6.33 (6.15, 6.52) 6.38 (6.24, 6.57) 6.33 (6.11, 6.47) 0.000
TM 11.15 (10.86, 11.37) 11.19 (10.91, 11.52) 11.32 (11.04, 11.55) 11.41 (11.27, 11.67) 0.000
VSIG2 5.74 (5.31, 6.16) 5.96 (5.45, 6.44) 6.20 (5.78, 6.72) 6.27 (5.86, 6.79) 0.000
AMBP 8.21 (8.05, 8.36) 8.18 (8.03, 8.36) 8.16 (8.04, 8.34) 8.13 (7.69, 8.36) 0.258
PRELP 8.94 (8.76, 9.08) 9.07 (8.90, 9.24) 9.23 (9.03, 9.41) 9.26 (9.10, 9.52) 0.000
HO_1 11.88 (11.59, 12.13) 12.08 (11.79, 12.39) 12.25 (11.86, 12.56) 12.67 (12.51, 13.07) 0.000
XCL1 5.40 (5.01, 5.81) 5.67 (5.24, 6.12) 5.75 (5.32, 6.18) 5.82 (5.54, 6.27) 0.000
IL16 6.99 (6.68, 7.39) 7.14 (6.75, 7.49) 7.22 (6.91, 7.57) 7.24 (6.76, 7.71) 0.001
SORT1 8.97 (8.72, 9.18) 9.00 (8.80, 9.19) 9.10 (8.94, 9.25) 9.10 (8.79, 9.28) 0.000
CEACAM8 5.42 (4.93, 5.87) 5.53 (5.08, 6.02) 5.67 (5.31, 6.16) 6.04 (5.37, 6.60) 0.000
PTX3 5.27 (4.92, 5.68) 5.59 (5.24, 6.04) 5.89 (5.50, 6.25) 6.30 (5.71, 6.70) 0.000
PSGL_1 4.63 (4.49, 4.78) 4.59 (4.43, 4.77) 4.65 (4.51, 4.85) 4.63 (4.41, 4.80) 0.006
CCL17 8.21 (7.68, 9.10) 8.07 (7.46, 8.81) 8.12 (7.55, 8.73) 7.78 (6.97, 8.43) 0.045
CCL3 7.04 (6.59, 7.43) 7.29 (6.86, 7.67) 7.48 (7.16, 7.90) 7.90 (7.31, 8.46) 0.000
MMP7 10.95 (10.65, 11.24) 11.00 (10.70, 11.30) 11.06 (10.74, 11.27) 11.08 (10.70, 11.25) 0.519
ITGB1BP2 4.51 (3.78, 5.77) 4.41 (3.76, 5.34) 4.35 (3.76, 5.22) 4.29 (3.62, 4.70) 0.173
DCN 5.60 (5.39, 5.77) 5.74 (5.55, 6.00) 5.82 (5.67, 6.03) 5.99 (5.82, 6.27) 0.000
Dkk_1 8.91 (8.48, 9.43) 8.94 (8.56, 9.43) 9.12 (8.64, 9.64) 9.18 (8.36, 10.09) 0.021
LPL 10.16 (9.85, 10.41) 9.96 (9.65, 10.27) 9.91 (9.59, 10.20) 9.92 (9.63, 10.06) 0.000
PRSS8 9.20 (8.95, 9.42) 9.33 (9.12, 9.54) 9.50 (9.27, 9.65) 9.45 (9.31, 9.70) 0.000
AGRP 6.44 (6.13, 6.74) 6.64 (6.35, 7.07) 6.80 (6.42, 7.17) 7.02 (6.63, 7.65) 0.000
HB_EGF 6.02 (5.84, 6.42) 5.96 (5.80, 6.21) 5.99 (5.83, 6.24) 6.00 (5.79, 6.08) 0.088
GDF_2 10.10 (9.58, 10.56) 9.90 (9.47, 10.31) 9.93 (9.42, 10.37) 9.79 (9.38, 10.38) 0.011
FABP2 9.60 (8.89, 10.28) 9.64 (8.95, 10.24) 9.46 (8.96, 10.21) 8.86 (8.59, 10.12) 0.199
THPO 3.57 (3.36, 3.84) 3.51 (3.28, 3.77) 3.49 (3.26, 3.76) 3.58 (3.34, 3.81) 0.068
MARCO 6.85 (6.70, 6.99) 6.87 (6.72, 7.03) 6.89 (6.75, 7.03) 6.93 (6.63, 7.05) 0.335
GT 2.64 (2.19, 3.10) 2.75 (2.37, 3.20) 2.75 (2.42, 3.17) 2.84 (2.42, 3.10) 0.094
BNP 3.98 (2.62, 5.22) 5.10 (3.70, 6.44) 5.73 (3.97, 7.25) 7.17 (5.22, 8.32) 0.000
MMP12 7.80 (7.11, 8.35) 7.82 (7.31, 8.43) 7.75 (7.23, 8.36) 7.71 (6.99, 8.32) 0.306
ACE2 4.74 (4.45, 5.14) 5.28 (4.88, 5.66) 5.95 (5.38, 6.39) 6.47 (5.79, 7.08) 0.000
PD_L2 4.04 (3.80, 4.27) 4.21 (3.95, 4.50) 4.34 (4.15, 4.66) 4.54 (4.27, 4.88) 0.000
CTSL1 7.55 (7.30, 7.78) 7.81 (7.49, 8.13) 8.01 (7.76, 8.36) 8.36 (8.02, 8.58) 0.000
hOSCAR 11.16 (11.00, 11.30) 11.22 (11.04, 11.39) 11.29 (11.14, 11.41) 11.34 (11.18, 11.52) 0.000
TNFRSF13B 10.80 (10.40, 11.16) 10.94 (10.59, 11.29) 10.98 (10.68, 11.35) 10.90 (10.67, 11.18) 0.000
TGM2 10.31 (9.78, 10.72) 10.43 (9.96, 10.89) 10.54 (10.04, 10.91) 10.78 (10.49, 11.47) 0.000
LEP 8.29 (7.23, 9.17) 8.00 (7.14, 8.78) 7.97 (6.87, 9.00) 6.54 (5.71, 7.68) 0.000
CA5A 3.01 (2.62, 3.51) 3.45 (2.85, 4.07) 3.88 (3.21, 4.72) 5.43 (4.05, 6.69) 0.000
CD4 6.00 (5.73, 6.26) 6.16 (5.89, 6.45) 6.18 (5.97, 6.51) 6.36 (6.20, 6.65) 0.000
NEMO 4.41 (3.87, 4.98) 4.42 (3.92, 5.03) 4.47 (4.04, 4.95) 4.51 (4.27, 4.73) 0.873
VEGFD 8.36 (8.07, 8.63) 8.46 (8.18, 8.76) 8.58 (8.36, 8.86) 8.59 (8.37, 8.85) 0.000
OID00469 4.13 (3.85, 4.54) 4.32 (4.00, 4.64) 4.46 (4.18, 4.82) 4.92 (4.34, 5.60) 0.000
HAOX1 5.38 (4.61, 6.26) 6.11 (5.16, 7.15) 7.07 (5.75, 8.97) 9.70 (7.95, 10.99) 0.000
PPP1R9B 3.75 (3.03, 4.75) 3.62 (2.92, 4.47) 3.55 (2.90, 4.39) 3.08 (2.76, 3.85) 0.055
GLB1 1.95 (1.72, 2.26) 1.94 (1.69, 2.17) 2.10 (1.84, 2.32) 1.96 (1.78, 2.44) 0.005
PSIP1 3.05 (2.75, 3.46) 3.22 (2.84, 3.67) 3.31 (3.01, 3.74) 3.63 (3.14, 4.13) 0.000
ZBTB16 1.70 (1.41, 2.51) 1.79 (1.45, 2.38) 1.84 (1.49, 2.37) 2.10 (1.68, 2.46) 0.133
IRAK4 2.82 (2.25, 4.11) 2.86 (2.24, 3.73) 2.84 (2.28, 3.57) 2.79 (2.23, 3.22) 0.718
TPSAB1 5.72 (5.35, 6.04) 5.70 (5.33, 6.08) 5.65 (5.27, 6.04) 5.39 (5.10, 5.76) 0.077
HCLS1 5.82 (5.17, 6.80) 5.88 (5.28, 6.56) 5.83 (5.39, 6.48) 5.88 (5.49, 6.58) 0.984
CNTNAP2 2.50 (2.23, 2.77) 2.53 (2.24, 2.85) 2.66 (2.30, 3.00) 2.36 (2.21, 2.75) 0.040
CLEC4G 4.07 (3.76, 4.38) 4.14 (3.87, 4.42) 4.23 (4.02, 4.54) 4.55 (4.19, 4.80) 0.000
IRF9 2.08 (1.86, 2.40) 2.12 (1.92, 2.42) 2.14 (1.96, 2.46) 2.10 (1.93, 2.39) 0.224
EDAR 2.33 (2.06, 2.78) 2.34 (2.05, 2.67) 2.35 (2.09, 2.64) 2.29 (1.91, 2.64) 0.642
OID00947 3.80 (3.24, 4.32) 4.28 (3.56, 5.16) 4.65 (4.01, 5.51) 5.36 (4.73, 6.69) 0.000
DGKZ 1.10 (0.95, 1.25) 1.11 (0.97, 1.24) 1.12 (1.02, 1.25) 1.06 (0.95, 1.23) 0.585
CLEC4C 4.21 (3.84, 4.63) 4.06 (3.66, 4.43) 3.95 (3.59, 4.32) 3.71 (3.26, 4.18) 0.000
IRAK1 2.83 (2.54, 3.31) 2.92 (2.65, 3.27) 2.92 (2.71, 3.22) 2.98 (2.80, 3.29) 0.328
CLEC4A 4.52 (4.31, 4.77) 4.44 (4.18, 4.68) 4.40 (4.11, 4.62) 4.33 (4.01, 4.59) 0.004
PRDX1 2.28 (1.97, 2.60) 2.30 (2.07, 2.61) 2.34 (2.15, 2.64) 2.59 (2.13, 3.32) 0.019
PRDX3 0.64 (0.30, 1.09) 0.67 (0.39, 1.08) 0.74 (0.45, 1.21) 0.96 (0.66, 1.57) 0.004
FGF2 1.29 (0.99, 1.90) 1.28 (1.00, 1.76) 1.28 (1.01, 1.69) 1.30 (1.07, 1.44) 0.734
PRDX5 5.81 (5.26, 6.82) 5.88 (5.29, 6.56) 5.93 (5.52, 6.51) 6.12 (5.49, 6.70) 0.580
DPP10 2.33 (2.10, 2.56) 2.42 (2.17, 2.74) 2.78 (2.43, 3.28) 3.28 (2.74, 3.99) 0.000
TRIM5 2.19 (1.94, 2.54) 2.26 (2.02, 2.52) 2.31 (2.09, 2.50) 2.30 (2.17, 2.50) 0.178
DCTN1 4.55 (3.98, 5.32) 4.66 (4.15, 5.21) 4.65 (4.17, 5.12) 4.59 (4.35, 4.95) 0.849
ITGA6 2.14 (1.91, 2.56) 2.09 (1.89, 2.43) 2.09 (1.88, 2.34) 2.10 (1.89, 2.27) 0.253
CDSN 3.92 (3.46, 4.25) 3.94 (3.51, 4.46) 3.94 (3.55, 4.42) 4.16 (3.58, 4.70) 0.145
GALNT3 3.07 (2.79, 3.36) 3.25 (2.98, 3.57) 3.35 (3.07, 3.68) 3.59 (3.10, 3.92) 0.000
FXYD5 1.45 (1.24, 1.72) 1.45 (1.28, 1.67) 1.49 (1.28, 1.65) 1.46 (1.20, 1.64) 0.884
TRAF2 2.59 (2.24, 2.93) 2.61 (2.36, 2.96) 2.66 (2.43, 2.96) 2.97 (2.59, 3.22) 0.003
TRIM21 3.88 (3.45, 4.31) 3.95 (3.58, 4.30) 3.94 (3.67, 4.36) 4.42 (3.88, 4.56) 0.010
LILRB4 4.25 (3.83, 4.63) 4.52 (4.09, 5.08) 4.66 (4.26, 5.13) 5.08 (4.65, 5.77) 0.000
NTF4 2.41 (2.17, 2.68) 2.45 (2.21, 2.69) 2.45 (2.24, 2.67) 2.49 (2.34, 2.77) 0.452
KRT19 2.64 (2.11, 3.16) 2.81 (2.31, 3.40) 3.07 (2.59, 3.71) 3.01 (2.55, 3.91) 0.000
ITM2A 4.08 (3.61, 4.46) 4.19 (3.80, 4.61) 4.24 (3.87, 4.69) 4.32 (3.91, 4.65) 0.004
HNMT 9.94 (9.51, 10.23) 10.08 (9.70, 10.52) 10.38 (9.97, 10.83) 11.07 (10.20, 11.99) 0.000
CCL11 7.92 (7.60, 8.19) 7.96 (7.65, 8.29) 8.02 (7.60, 8.29) 7.92 (7.59, 8.31) 0.418
MILR1 3.76 (3.45, 4.10) 4.00 (3.63, 4.46) 4.18 (3.84, 4.67) 4.57 (3.98, 4.84) 0.000
EGLN1 1.92 (1.74, 2.12) 2.01 (1.83, 2.23) 2.15 (1.99, 2.39) 2.62 (2.17, 3.22) 0.000
NFATC3 1.23 (1.00, 1.55) 1.35 (1.06, 1.72) 1.56 (1.13, 2.12) 1.94 (1.44, 3.43) 0.000
LY75 3.57 (3.27, 3.86) 3.66 (3.37, 3.95) 3.71 (3.46, 4.02) 3.84 (3.37, 4.00) 0.005
EIF5A 0.83 (0.67, 0.98) 0.85 (0.69, 1.05) 0.84 (0.68, 1.02) 0.82 (0.62, 1.05) 0.328
EIF4G1 4.20 (3.53, 5.37) 4.38 (3.68, 5.19) 4.39 (3.78, 5.18) 4.63 (4.16, 5.12) 0.515
CD28 2.28 (2.13, 2.59) 2.40 (2.16, 2.68) 2.53 (2.29, 2.85) 2.57 (2.17, 2.91) 0.000
PTH1R 4.87 (4.63, 5.11) 4.88 (4.65, 5.16) 4.89 (4.65, 5.17) 4.87 (4.56, 5.05) 0.950
BIRC2 1.33 (1.16, 1.55) 1.32 (1.18, 1.50) 1.32 (1.21, 1.50) 1.39 (1.30, 1.53) 0.378
HSD11B1 3.93 (3.65, 4.22) 3.96 (3.68, 4.28) 3.93 (3.64, 4.22) 3.97 (3.61, 4.48) 0.803
NF2 0.03 (-0.42, 0.99) 0.03 (-0.38, 0.67) -0.02 (-0.39, 0.56) 0.00 (-0.21, 0.20) 0.840
PLXNA4 4.97 (4.40, 6.04) 4.92 (4.27, 5.76) 4.89 (4.35, 5.46) 4.94 (4.18, 5.20) 0.118
SH2B3 3.79 (3.22, 4.85) 3.78 (3.05, 4.59) 3.82 (3.16, 4.61) 3.45 (3.17, 3.93) 0.242
FCRL3 1.55 (1.31, 1.79) 1.64 (1.39, 1.93) 1.72 (1.51, 1.96) 1.54 (1.25, 1.75) 0.000
CKAP4 6.17 (5.82, 6.57) 6.36 (5.99, 6.78) 6.49 (6.19, 6.86) 6.82 (6.41, 7.37) 0.000
JUN 0.80 (0.58, 1.09) 0.82 (0.59, 1.08) 0.87 (0.60, 1.12) 0.83 (0.73, 1.13) 0.452
HEXIM1 5.33 (4.75, 6.10) 5.43 (4.93, 6.02) 5.48 (5.00, 6.03) 5.51 (5.17, 5.89) 0.312
CLEC4D 4.63 (4.05, 5.09) 4.70 (4.17, 5.22) 4.76 (4.38, 5.39) 5.24 (4.65, 6.16) 0.001
PRKCQ 1.83 (1.60, 2.09) 1.81 (1.58, 2.07) 1.79 (1.52, 2.04) 1.73 (1.57, 2.05) 0.425
MGMT 4.49 (3.80, 5.50) 4.62 (3.85, 5.49) 4.79 (4.04, 5.53) 5.30 (4.49, 6.85) 0.018
TREM1 3.88 (3.48, 4.28) 4.06 (3.65, 4.48) 4.21 (3.77, 4.48) 4.41 (4.04, 4.77) 0.000
CXADR 3.08 (2.76, 3.44) 3.35 (2.97, 3.86) 3.74 (3.26, 4.21) 4.29 (3.94, 4.98) 0.000
IL10 4.45 (4.16, 4.86) 4.68 (4.36, 5.07) 4.87 (4.43, 5.30) 5.22 (4.78, 5.60) 0.000
SRPK2 1.61 (1.20, 2.27) 1.60 (1.23, 2.17) 1.54 (1.30, 2.00) 1.58 (1.42, 2.09) 0.978
KLRD1 7.18 (6.76, 7.58) 7.37 (6.94, 7.89) 7.52 (7.06, 7.90) 7.45 (6.92, 8.14) 0.000
BACH1 1.85 (1.67, 2.26) 1.96 (1.74, 2.25) 1.98 (1.78, 2.23) 2.06 (1.89, 2.36) 0.042
PIK3AP1 3.79 (3.40, 4.34) 3.81 (3.39, 4.29) 3.92 (3.51, 4.40) 4.28 (3.66, 4.79) 0.017
SPRY2 3.42 (2.81, 4.27) 3.28 (2.73, 4.04) 3.24 (2.76, 3.76) 3.28 (2.83, 3.49) 0.460
STC1 7.34 (7.03, 7.60) 7.50 (7.22, 7.74) 7.61 (7.33, 7.85) 7.71 (7.53, 7.81) 0.000
ARNT 1.08 (0.84, 1.52) 1.12 (0.82, 1.49) 1.11 (0.84, 1.49) 1.14 (0.88, 1.54) 0.959
FAM3B 5.85 (5.45, 6.16) 5.95 (5.59, 6.31) 6.07 (5.71, 6.33) 5.92 (5.56, 6.26) 0.001
SH2D1A 2.21 (1.96, 2.43) 2.30 (2.00, 2.70) 2.30 (2.03, 2.71) 2.17 (1.82, 2.65) 0.022
ICA1 1.68 (1.49, 2.08) 1.66 (1.47, 1.90) 1.65 (1.52, 1.89) 1.66 (1.57, 1.88) 0.728
DFFA 5.00 (4.61, 5.57) 5.12 (4.79, 5.48) 5.23 (4.99, 5.60) 5.48 (5.17, 5.89) 0.000
DCBLD2 8.54 (8.33, 8.75) 8.55 (8.32, 8.78) 8.68 (8.45, 8.91) 8.71 (8.53, 8.99) 0.000
FCRL6 4.40 (3.94, 4.81) 4.49 (4.06, 4.96) 4.48 (4.08, 5.01) 4.03 (3.61, 5.06) 0.071
NCR1 4.24 (3.86, 4.54) 4.36 (3.98, 4.81) 4.41 (3.94, 4.89) 4.38 (3.86, 4.77) 0.003
CXCL12 1.81 (1.68, 1.93) 1.85 (1.71, 1.99) 1.88 (1.73, 2.01) 1.96 (1.79, 2.09) 0.002
AREG 4.11 (3.74, 4.51) 4.41 (3.97, 4.89) 4.77 (4.32, 5.21) 5.02 (4.73, 5.75) 0.000
IFNLR1 3.22 (2.98, 3.47) 3.25 (3.00, 3.47) 3.29 (3.06, 3.47) 3.16 (2.95, 3.53) 0.673
DAPP1 4.69 (3.63, 6.58) 4.40 (3.32, 5.86) 4.28 (3.28, 5.52) 3.56 (3.11, 4.30) 0.001
PADI2 1.39 (1.21, 1.58) 1.48 (1.30, 1.73) 1.54 (1.37, 1.83) 1.62 (1.31, 2.06) 0.000
SIT1 3.00 (2.72, 3.30) 3.09 (2.73, 3.42) 3.21 (2.90, 3.63) 3.01 (2.82, 3.39) 0.001
MASP1 2.97 (2.81, 3.11) 3.05 (2.84, 3.29) 3.20 (2.96, 3.40) 3.09 (2.87, 3.34) 0.000
LAMP3 5.37 (4.88, 5.80) 5.48 (5.03, 5.91) 5.45 (5.06, 5.97) 5.41 (4.59, 6.02) 0.127
CLEC7A 4.30 (3.83, 4.59) 4.45 (3.91, 4.89) 4.44 (4.16, 4.98) 4.69 (3.76, 5.24) 0.001
CLEC6A 2.97 (2.68, 3.24) 3.12 (2.78, 3.49) 3.19 (2.90, 3.47) 3.51 (3.12, 3.92) 0.000
DDX58 3.14 (2.88, 3.58) 3.24 (2.95, 3.62) 3.25 (3.03, 3.59) 3.50 (3.05, 3.96) 0.057
IL12RB1 2.79 (2.51, 3.07) 2.91 (2.65, 3.22) 3.02 (2.68, 3.32) 3.08 (2.77, 3.50) 0.000
TANK 2.25 (1.92, 2.67) 2.26 (1.89, 2.62) 2.30 (1.97, 2.67) 2.20 (1.96, 2.57) 0.676
ITGA11 3.83 (3.55, 4.20) 3.74 (3.39, 4.06) 3.76 (3.38, 4.06) 3.62 (3.34, 3.83) 0.005
KPNA1 0.29 (-0.07, 1.03) 0.32 (-0.02, 1.11) 0.24 (-0.08, 0.78) 0.29 (0.05, 1.34) 0.251
LAG3 3.37 (3.10, 3.72) 3.66 (3.36, 4.06) 3.76 (3.39, 4.18) 3.88 (3.52, 4.32) 0.000
IL5 1.35 (1.11, 1.84) 1.34 (1.11, 1.67) 1.43 (1.20, 1.85) 1.22 (1.02, 1.36) 0.027
CD83 3.78 (3.49, 4.04) 3.79 (3.52, 4.15) 3.89 (3.54, 4.15) 3.91 (3.58, 4.12) 0.426
ITGB6 3.57 (3.31, 3.86) 3.74 (3.48, 3.99) 3.82 (3.60, 4.12) 3.91 (3.48, 4.14) 0.000
BTN3A2 3.89 (3.56, 4.14) 4.01 (3.66, 4.38) 4.01 (3.80, 4.38) 4.42 (3.94, 4.74) 0.000
TXLNA 5.46 (4.82, 6.26) 5.49 (4.90, 6.13) 5.51 (4.97, 6.23) 5.84 (5.33, 6.25) 0.446
VEGFA 10.86 (10.54, 11.12) 10.95 (10.64, 11.29) 11.07 (10.73, 11.32) 11.35 (10.88, 11.64) 0.000
CPE 6.21 (5.92, 6.48) 6.27 (6.00, 6.57) 6.35 (6.09, 6.61) 6.25 (5.99, 6.74) 0.010
KLK13 4.73 (4.41, 4.96) 4.71 (4.40, 5.01) 4.71 (4.43, 4.98) 4.89 (4.11, 5.51) 0.873
CEACAM1 7.57 (7.43, 7.67) 7.59 (7.49, 7.69) 7.67 (7.58, 7.77) 7.76 (7.68, 7.84) 0.000
MSLN 5.01 (4.45, 5.50) 5.10 (4.64, 5.71) 5.28 (4.65, 5.98) 5.06 (4.76, 5.87) 0.026
TNFSF13 9.24 (8.95, 9.56) 9.44 (9.16, 9.78) 9.58 (9.33, 9.83) 9.68 (9.43, 10.10) 0.000
EGF 7.24 (6.35, 8.40) 6.83 (5.94, 7.92) 6.77 (5.74, 7.75) 6.22 (5.70, 6.94) 0.000
TNFRSF6B 6.81 (6.37, 7.30) 7.07 (6.57, 7.73) 7.15 (6.79, 7.92) 8.12 (7.26, 8.58) 0.000
SYND1 8.29 (7.96, 8.65) 8.61 (8.20, 9.03) 8.92 (8.48, 9.32) 9.41 (8.84, 10.40) 0.000
TGFR_2 7.47 (7.13, 7.76) 7.51 (7.19, 7.90) 7.60 (7.31, 7.93) 7.77 (7.24, 8.15) 0.004
CD48 7.33 (7.11, 7.53) 7.41 (7.19, 7.65) 7.46 (7.29, 7.71) 7.59 (7.18, 7.83) 0.000
SCAMP3 5.39 (4.70, 6.37) 5.34 (4.67, 6.26) 5.39 (4.84, 6.06) 5.50 (4.95, 5.86) 0.934
LY9 6.49 (6.26, 6.66) 6.65 (6.37, 6.92) 6.73 (6.51, 6.95) 6.83 (6.54, 7.08) 0.000
ITGAV 5.85 (5.65, 6.07) 5.83 (5.62, 6.05) 5.88 (5.66, 6.07) 5.98 (5.65, 6.14) 0.240
TRAIL 8.77 (8.55, 9.00) 8.70 (8.43, 8.93) 8.50 (8.24, 8.79) 8.38 (7.97, 8.84) 0.000
hK11 7.96 (7.64, 8.28) 8.09 (7.74, 8.56) 8.32 (7.92, 8.58) 8.23 (7.85, 8.73) 0.000
GPC1 6.45 (6.11, 6.67) 6.45 (6.20, 6.72) 6.56 (6.26, 6.82) 6.65 (6.40, 7.09) 0.000
TFPI_2 9.93 (9.57, 10.25) 10.04 (9.67, 10.45) 10.15 (9.84, 10.57) 10.49 (9.94, 11.02) 0.000
hK8 8.41 (8.17, 8.73) 8.41 (8.09, 8.73) 8.45 (8.11, 8.80) 8.57 (8.01, 8.84) 0.889
VEGFR_2 8.15 (7.94, 8.27) 8.05 (7.87, 8.22) 8.06 (7.83, 8.21) 8.07 (7.78, 8.27) 0.011
LYPD3 5.67 (5.41, 5.95) 5.67 (5.38, 5.93) 5.75 (5.50, 6.03) 5.98 (5.66, 6.18) 0.004
PODXL 4.62 (4.49, 4.76) 4.62 (4.46, 4.75) 4.63 (4.50, 4.78) 4.74 (4.51, 4.90) 0.150
S100A4 3.42 (3.17, 3.73) 3.40 (3.11, 3.70) 3.31 (3.05, 3.62) 3.35 (3.19, 3.70) 0.114
IGF1R 4.96 (4.75, 5.17) 5.04 (4.84, 5.34) 5.13 (4.91, 5.40) 5.38 (5.06, 5.67) 0.000
ERBB2 9.44 (9.23, 9.67) 9.50 (9.30, 9.72) 9.67 (9.45, 9.89) 9.66 (9.26, 10.14) 0.000
ERBB3 8.86 (8.66, 9.03) 8.79 (8.61, 8.95) 8.85 (8.67, 9.03) 8.90 (8.69, 9.08) 0.001
SPARC 6.86 (6.65, 7.03) 6.81 (6.60, 6.99) 6.85 (6.65, 7.00) 6.85 (6.63, 6.97) 0.071
GZMH 5.07 (4.64, 5.66) 5.34 (4.82, 5.98) 5.46 (5.00, 5.95) 5.83 (5.06, 6.26) 0.000
TGF_alpha 3.93 (3.67, 4.17) 4.11 (3.81, 4.41) 4.23 (3.96, 4.54) 4.49 (4.19, 5.00) 0.000
FURIN 10.33 (10.08, 10.62) 10.31 (10.05, 10.61) 10.36 (10.07, 10.66) 10.32 (9.90, 10.52) 0.593
CYR61 7.59 (7.25, 7.92) 7.58 (7.17, 7.96) 7.67 (7.26, 8.09) 8.13 (7.32, 8.56) 0.029
hK14 8.75 (8.36, 9.18) 8.72 (8.35, 9.14) 8.64 (8.28, 8.91) 8.51 (8.10, 8.98) 0.016
FADD 2.46 (2.17, 3.03) 2.45 (2.13, 2.86) 2.43 (2.17, 2.74) 2.52 (2.23, 2.94) 0.706
PVRL4 7.04 (6.67, 7.35) 7.11 (6.67, 7.57) 7.14 (6.79, 7.53) 7.33 (6.89, 7.88) 0.040
FASLG 9.83 (9.46, 10.16) 9.84 (9.47, 10.20) 9.82 (9.45, 10.20) 9.50 (9.28, 10.09) 0.248
EPHA2 4.42 (4.18, 4.70) 4.54 (4.22, 4.91) 4.65 (4.41, 5.06) 4.89 (4.46, 5.21) 0.000
ITGB5 9.42 (9.17, 9.66) 9.44 (9.21, 9.66) 9.57 (9.30, 9.78) 9.66 (9.33, 9.93) 0.000
Gal_1 8.21 (8.05, 8.35) 8.19 (8.04, 8.33) 8.17 (8.04, 8.30) 8.26 (8.10, 8.36) 0.520
SEZ6L 5.25 (5.06, 5.43) 5.24 (5.03, 5.46) 5.19 (5.01, 5.45) 5.26 (5.01, 5.53) 0.693
GPNMB 8.34 (8.19, 8.46) 8.37 (8.22, 8.51) 8.48 (8.34, 8.65) 8.57 (8.43, 8.64) 0.000
CAIX 4.79 (4.34, 5.23) 5.03 (4.58, 5.55) 5.41 (4.91, 5.89) 5.57 (5.19, 6.26) 0.000
MIA 11.60 (11.42, 11.78) 11.59 (11.39, 11.75) 11.53 (11.31, 11.67) 11.48 (11.14, 11.68) 0.002
CTSV 5.18 (4.83, 5.53) 5.16 (4.80, 5.49) 5.17 (4.79, 5.53) 4.99 (4.65, 5.56) 0.656
CD27 10.39 (10.10, 10.72) 10.54 (10.14, 10.95) 10.68 (10.27, 10.98) 10.80 (10.42, 11.22) 0.000
XPNPEP2 9.82 (9.18, 10.26) 9.75 (9.01, 10.25) 9.76 (8.93, 10.25) 9.72 (9.03, 10.41) 0.587
ERBB4 6.27 (6.05, 6.45) 6.33 (6.11, 6.51) 6.44 (6.24, 6.63) 6.63 (6.26, 6.83) 0.000
HGF 9.15 (8.77, 9.49) 9.40 (9.05, 9.82) 9.65 (9.24, 10.15) 10.06 (9.76, 10.69) 0.000
CDKN1A 3.62 (3.17, 4.75) 3.72 (3.09, 4.41) 3.69 (3.15, 4.29) 3.59 (3.25, 4.20) 0.900
DLL1 10.72 (10.40, 10.93) 10.81 (10.52, 11.09) 10.87 (10.67, 11.18) 11.18 (10.89, 11.41) 0.000
MK 7.52 (7.08, 8.05) 7.61 (7.13, 8.20) 7.75 (7.35, 8.30) 8.14 (7.56, 8.81) 0.001
ABL1 4.41 (3.96, 4.93) 4.43 (4.01, 4.94) 4.46 (4.09, 4.86) 4.69 (4.25, 5.11) 0.471
FGF_BP1 6.86 (6.62, 7.11) 6.91 (6.66, 7.23) 6.97 (6.67, 7.38) 7.14 (6.89, 7.64) 0.005
TLR3 6.77 (6.33, 7.12) 6.84 (6.30, 7.31) 7.01 (6.47, 7.43) 7.28 (6.64, 7.69) 0.000
LYN 4.50 (4.09, 5.24) 4.47 (4.01, 5.08) 4.45 (4.04, 4.95) 4.49 (4.05, 4.69) 0.336
RET 5.57 (5.28, 6.01) 5.57 (5.14, 5.97) 5.62 (5.29, 6.04) 5.57 (5.11, 6.19) 0.350
VIM 5.98 (5.58, 6.46) 6.24 (5.79, 6.78) 6.42 (6.01, 6.87) 6.98 (6.48, 7.24) 0.000
TNFRSF19 5.81 (5.37, 6.11) 5.90 (5.49, 6.47) 5.94 (5.55, 6.36) 5.90 (5.46, 6.82) 0.004
CRNN 5.04 (4.54, 5.59) 4.85 (4.29, 5.39) 4.69 (4.18, 5.30) 4.68 (3.97, 5.31) 0.002
TCL1A 5.48 (4.83, 6.12) 5.34 (4.51, 6.15) 5.17 (4.33, 5.89) 4.56 (3.98, 5.47) 0.003
CD160 7.29 (6.81, 7.58) 7.34 (6.94, 7.79) 7.28 (6.89, 7.73) 7.55 (6.98, 7.96) 0.074
TNFRSF4 5.52 (5.16, 5.93) 5.66 (5.27, 6.12) 5.72 (5.31, 6.11) 5.91 (5.44, 6.34) 0.006
MIC_AB 5.82 (5.29, 6.24) 6.09 (5.53, 6.48) 6.25 (5.73, 6.66) 6.48 (5.76, 7.02) 0.000
WISP_1 7.62 (7.28, 7.97) 7.85 (7.44, 8.33) 8.09 (7.80, 8.55) 8.52 (7.84, 8.85) 0.000
CXL17 6.78 (6.39, 7.16) 6.97 (6.57, 7.33) 7.01 (6.63, 7.38) 6.89 (6.54, 7.41) 0.001
PPY 11.17 (10.21, 11.86) 11.56 (10.76, 12.34) 12.00 (11.12, 12.59) 12.26 (11.16, 12.82) 0.000
S100A11 4.56 (4.40, 4.72) 4.64 (4.47, 4.84) 4.67 (4.52, 4.80) 4.81 (4.71, 4.98) 0.000
OID00728 3.99 (3.70, 4.32) 4.29 (3.92, 4.74) 4.60 (4.19, 5.01) 5.07 (4.69, 5.59) 0.000
ESM_1 10.93 (10.55, 11.32) 11.16 (10.68, 11.53) 11.24 (10.69, 11.76) 11.46 (11.06, 11.71) 0.000
CD207 5.02 (4.76, 5.28) 4.95 (4.65, 5.28) 4.96 (4.59, 5.31) 4.86 (4.62, 5.27) 0.387
ICOSLG 6.93 (6.73, 7.13) 6.93 (6.73, 7.13) 6.99 (6.75, 7.15) 6.94 (6.68, 7.16) 0.745
WFDC2 10.07 (9.68, 10.33) 10.17 (9.85, 10.49) 10.30 (10.02, 10.51) 10.38 (10.16, 10.72) 0.000
CXCL13 9.09 (8.61, 9.57) 9.32 (8.82, 9.91) 9.43 (8.84, 10.04) 9.45 (8.89, 10.00) 0.000
CD70 4.78 (4.44, 5.17) 4.78 (4.38, 5.13) 4.82 (4.50, 5.14) 4.89 (4.55, 5.30) 0.732
RSPO3 6.08 (5.63, 6.59) 6.25 (5.79, 6.87) 6.29 (5.82, 6.76) 6.63 (5.76, 7.51) 0.002
FR_gamma 7.75 (7.52, 7.95) 7.78 (7.57, 8.01) 7.79 (7.64, 8.04) 7.84 (7.46, 8.09) 0.243
CEACAM5 3.14 (2.62, 3.71) 3.17 (2.71, 3.72) 3.22 (2.85, 3.71) 3.39 (2.80, 4.01) 0.292
VEGFR_3 8.70 (8.48, 8.86) 8.72 (8.54, 8.86) 8.73 (8.52, 8.88) 8.87 (8.73, 8.97) 0.010
MUC_16 5.76 (5.20, 6.67) 6.44 (5.54, 7.73) 6.89 (5.80, 8.60) 8.23 (6.54, 9.35) 0.000
WIF_1 7.01 (6.73, 7.33) 7.03 (6.70, 7.41) 7.06 (6.72, 7.45) 7.04 (6.55, 7.64) 0.593
GZMB 3.60 (3.25, 3.93) 3.69 (3.36, 4.12) 3.70 (3.30, 4.12) 3.87 (3.57, 4.15) 0.013
FCRLB 3.25 (2.97, 3.63) 3.49 (3.15, 4.03) 3.84 (3.44, 4.25) 4.31 (3.86, 4.75) 0.000
1 n (%); Median (IQR)
2 Pearson’s Chi-squared test; Fisher’s exact test; Kruskal-Wallis rank sum test