Characteristic	FH Total Effect			FH Direct + LDL Mediation			Prop. Mediated
	log(OR)1	p-value	95% CI	log(OR)1	p-value	95% CI	Average	p-value	95% CI
FH	-0.68	<0.001	[-0.81, -0.55]	-0.57	<0.001	[-0.71, -0.43]
LDL				-0.33	<0.001	[-0.50, -0.16]
LDL							0.15	0.000	[0.09, 0.21]
FH	-0.16	<0.001	[-0.23, -0.09]	-0.17	<0.001	[-0.25, -0.09]
LDL				0.05	0.2	[-0.03, 0.14]
LDL							-0.11	0.000	[-0.14, -0.04]
FH	0.28	<0.001	[0.24, 0.32]	0.21	<0.001	[0.17, 0.26]
LDL				0.20	<0.001	[0.16, 0.24]
LDL							0.24	0.000	[0.18, 0.22]
FH	0.31	<0.001	[0.28, 0.34]	0.24	<0.001	[0.21, 0.28]
LDL				0.20	<0.001	[0.16, 0.24]
LDL							0.21	0.000	[0.20, 0.22]
FH	0.23	<0.001	[0.17, 0.29]	0.13	<0.001	[0.06, 0.20]
LDL				0.22	<0.001	[0.15, 0.29]
LDL							0.36	0.000	[0.31, 0.36]
FH	0.21	<0.001	[0.13, 0.29]	0.16	<0.001	[0.08, 0.24]
LDL				0.20	<0.001	[0.11, 0.29]
LDL							0.29	0.000	[0.24, 0.36]
FH	-0.16	0.008	[-0.27, -0.04]	-0.15	0.018	[-0.27, -0.03]
LDL				-0.09	0.3	[-0.25, 0.06]
LDL							0.16	0.000	[0.13, 0.27]
1 OR = Odds Ratio