Characteristic	Total FH Effect			LDL Effect			FH + LDL Mediation Effects
	log(OR)1	p-value	95% CI	log(OR)1	p-value	95% CI	log(OR)1	p-value	95% CI
FH	-0.69	<0.001	[-0.83, -0.56]	1.64	<0.001	[1.62, 1.67]	-0.58	<0.001	[-0.72, -0.44]
LDL							-0.33	<0.001	[-0.51, -0.17]
FH	-0.18	<0.001	[-0.25, -0.11]	1.64	<0.001	[1.62, 1.67]	-0.21	<0.001	[-0.29, -0.14]
LDL							0.12	0.004	[0.04, 0.20]
FH	0.28	<0.001	[0.24, 0.32]	1.64	<0.001	[1.62, 1.67]	0.19	<0.001	[0.15, 0.23]
LDL							0.26	<0.001	[0.22, 0.30]
FH	0.30	<0.001	[0.26, 0.33]	1.64	<0.001	[1.62, 1.67]	0.20	<0.001	[0.17, 0.24]
LDL							0.28	<0.001	[0.24, 0.32]
FH	0.16	<0.001	[0.11, 0.22]	1.64	<0.001	[1.62, 1.67]	0.06	0.077	[-0.01, 0.12]
LDL							0.32	<0.001	[0.25, 0.38]
FH	-0.05	0.4	[-0.17, 0.06]	1.64	<0.001	[1.62, 1.67]	0.13	0.047	[0.00, 0.25]
LDL							-0.62	<0.001	[-0.78, -0.46]
FH	0.29	<0.001	[0.22, 0.37]	1.64	<0.001	[1.62, 1.67]	0.34	<0.001	[0.26, 0.42]
LDL							-0.17	<0.001	[-0.26, -0.08]
FH	0.11	0.029	[0.01, 0.22]	1.64	<0.001	[1.62, 1.67]	0.23	<0.001	[0.12, 0.34]
LDL							-0.42	<0.001	[-0.55, -0.30]
FH	0.05	0.4	[-0.08, 0.18]	1.64	<0.001	[1.62, 1.67]	0.16	0.023	[0.02, 0.29]
LDL							-0.38	<0.001	[-0.54, -0.22]
1 OR = Odds Ratio