Characteristic	Total FH Effect			LDL Mediation			Direct + Indirect effects
Characteristic	log(OR)¹	p-value	95% CI	log(OR)¹	p-value	95% CI	log(OR)¹	p-value	95% CI
FH	-0.69	<0.001	[-0.83--0.56]	1.64	<0.001	[1.62-1.67]	-0.58	<0.001	[-0.72--0.44]
LDL							-0.33	<0.001	[-0.51--0.17]
FH	-0.18	<0.001	[-0.25--0.11]	1.64	<0.001	[1.62-1.67]	-0.21	<0.001	[-0.29--0.14]
LDL							0.12	0.004	[0.04-0.20]
FH	0.28	<0.001	[0.24-0.32]	1.64	<0.001	[1.62-1.67]	0.19	<0.001	[0.15-0.23]
LDL							0.26	<0.001	[0.22-0.30]
FH	0.30	<0.001	[0.26-0.33]	1.64	<0.001	[1.62-1.67]	0.20	<0.001	[0.17-0.24]
LDL							0.28	<0.001	[0.24-0.32]
FH	0.16	<0.001	[0.11-0.22]	1.64	<0.001	[1.62-1.67]	0.06	0.077	[-0.01-0.12]
LDL							0.32	<0.001	[0.25-0.38]
FH	-0.05	0.4	[-0.17-0.06]	1.64	<0.001	[1.62-1.67]	0.13	0.047	[0.00-0.25]
LDL							-0.62	<0.001	[-0.78--0.46]
FH	0.29	<0.001	[0.22-0.37]	1.64	<0.001	[1.62-1.67]	0.34	<0.001	[0.26-0.42]
LDL							-0.17	<0.001	[-0.26--0.08]
FH	0.11	0.029	[0.01-0.22]	1.64	<0.001	[1.62-1.67]	0.23	<0.001	[0.12-0.34]
LDL							-0.42	<0.001	[-0.55--0.30]
FH	0.05	0.4	[-0.08-0.18]	1.64	<0.001	[1.62-1.67]	0.16	0.023	[0.02-0.29]
LDL							-0.38	<0.001	[-0.54--0.22]
¹ OR = Odds Ratio