| Characteristic | Overall N = 2311 |
Amyloid cardiomyopathy N = 1191 |
Hypertensive organ damage (no CMP) N = 301 |
Hypertrophic cardiomyopathy N = 821 |
p-value2 |
|---|---|---|---|---|---|
| Race | 0.3 | ||||
| Black or African American | 11 (4.8%) | 3 (2.5%) | 2 (6.9%) | 6 (7.6%) | |
| More Than One Race | 1 (0.4%) | 1 (0.8%) | 0 (0%) | 0 (0%) | |
| White | 215 (95%) | 115 (97%) | 27 (93%) | 73 (92%) | |
| Gender | 0.14 | ||||
| Female | 61 (26%) | 26 (22%) | 7 (23%) | 28 (34%) | |
| Male | 170 (74%) | 93 (78%) | 23 (77%) | 54 (66%) | |
| BMI..kg.m2. | 25.8 (23.4, 27.9) | 25.4 (22.8, 27.0) | 26.4 (22.6, 30.1) | 26.3 (24.1, 28.4) | 0.072 |
| Age.at.Diagnosis..years. | 72 (55, 81) | 79 (74, 83) | 68 (56, 75) | 54 (37, 65) | <0.001 |
| Age.at.enrollment..years. | 73 (59, 81) | 79 (74, 83) | 68 (62, 77) | 60 (50, 71) | <0.001 |
| Type.of.Amyloid.Cardiomyopathy | |||||
| AL | 17 (16%) | 17 (16%) | 0 (NA%) | 0 (NA%) | |
| aTTR mutated | 11 (10%) | 11 (10%) | 0 (NA%) | 0 (NA%) | |
| aTTR wild type | 79 (74%) | 79 (74%) | 0 (NA%) | 0 (NA%) | |
| Arterial.Hypertension | 150 (66%) | 88 (75%) | 26 (90%) | 36 (44%) | <0.001 |
| Dyslipidaemia | 120 (52%) | 65 (55%) | 21 (72%) | 34 (41%) | 0.012 |
| Diabetes.Mellitus | 35 (15%) | 22 (19%) | 6 (21%) | 7 (8.5%) | 0.083 |
| Smoking.History | 0.12 | ||||
| Active/Ongoing | 12 (5.2%) | 2 (1.7%) | 2 (6.9%) | 8 (9.8%) | |
| Never | 146 (64%) | 77 (65%) | 18 (62%) | 51 (62%) | |
| Prior | 71 (31%) | 39 (33%) | 9 (31%) | 23 (28%) | |
| Family.History..choice.Hypertrophic.cardiomyopathy. | <0.001 | ||||
| Checked | 18 (7.8%) | 0 (0%) | 0 (0%) | 18 (22%) | |
| Unchecked | 213 (92%) | 119 (100%) | 30 (100%) | 64 (78%) | |
| Family.History..choice.Amyloid.cardiomyopathy. | 0.13 | ||||
| Checked | 7 (3.0%) | 6 (5.0%) | 1 (3.3%) | 0 (0%) | |
| Unchecked | 224 (97%) | 113 (95%) | 29 (97%) | 82 (100%) | |
| Family.History..choice.Non.ischemic.dilated.cardiomyopathy. | 0.13 | ||||
| Checked | 1 (0.4%) | 0 (0%) | 1 (3.3%) | 0 (0%) | |
| Unchecked | 230 (100%) | 119 (100%) | 29 (97%) | 82 (100%) | |
| Family.History..choice.Ischemic.heart.disease. | 0.6 | ||||
| Checked | 32 (14%) | 14 (12%) | 5 (17%) | 13 (16%) | |
| Unchecked | 199 (86%) | 105 (88%) | 25 (83%) | 69 (84%) | |
| History.of.Coronary.Heart.Disease | 31 (13%) | 22 (18%) | 3 (10%) | 6 (7.3%) | 0.070 |
| History.of.Myocardial.Infarction | 11 (35%) | 8 (36%) | 1 (33%) | 2 (33%) | >0.9 |
| History.of.Carotid.Stenosis...20.. | 25 (11%) | 14 (12%) | 5 (17%) | 6 (7.3%) | 0.3 |
| History.of.Peripheral.Vascular.Disease | 10 (4.3%) | 9 (7.6%) | 0 (0%) | 1 (1.2%) | 0.068 |
| History.of.Prior.Stroke.TIA | 12 (5.2%) | 4 (3.4%) | 0 (0%) | 8 (9.8%) | 0.069 |
| History.of.Supraventricular.Arrhythmia | 102 (45%) | 71 (60%) | 8 (29%) | 23 (28%) | <0.001 |
| History.of.Ventricular.Arrhythmia | 40 (17%) | 14 (12%) | 3 (11%) | 23 (28%) | 0.010 |
| Cardiac.Implantable.Electronic.Device | 48 (21%) | 21 (18%) | 5 (18%) | 22 (28%) | 0.2 |
| History.of.Severe.Chronic.Renal.Failure | 28 (12%) | 22 (19%) | 3 (11%) | 3 (3.8%) | 0.004 |
| History.of.Chronic.Obstructive.Pulmonary.Disease | 18 (7.8%) | 12 (10%) | 2 (6.9%) | 4 (4.9%) | 0.5 |
| History.of.Obstructive.Sleep.Apnea.Syndrome | 17 (7.4%) | 10 (8.4%) | 2 (6.9%) | 5 (6.1%) | 0.9 |
| History.of.Carpal.Tunnel.Syndrome | 53 (28%) | 48 (42%) | 2 (9.1%) | 3 (6.0%) | <0.001 |
| 1 n (%); Median (Q1, Q3) | |||||
| 2 Fisher’s exact test; Pearson’s Chi-squared test; Kruskal-Wallis rank sum test | |||||