Preliminary Results with Known Issue Affecting Small Number of Sister Study Participants

Primary
Outcome Person Years Events HR Lower HR Est. HR Upper p Value Parameter Est. Std. Error
PM2.5 Non-accidental Mortality 7,687,414 132,205 1.019 1.028 1.038 <.0001 0.0093 0.0016
CVD Mortality 7,148,127 33,279 1.045 1.067 1.089 <.0001 0.0215 0.0035
Cardiovascular Disease 7,257,889 70,623 1.036 1.049 1.062 <.0001 0.0159 0.0021
Myocardial Infarction 6,428,266 30,639 1.037 1.057 1.077 <.0001 0.0185 0.0032
Stroke 6,370,430 27,376 1.007 1.026 1.046 0.0088 0.0087 0.0033
NO2 Non-accidental Mortality 7,687,414 132,205 1.022 1.031 1.040 <.0001 0.0051 0.0007
CVD Mortality 7,148,127 33,279 1.033 1.055 1.076 <.0001 0.0089 0.0017
Cardiovascular Disease 7,257,889 70,623 1.008 1.020 1.033 0.0015 0.0033 0.0010
Myocardial Infarction 6,428,266 30,639 1.019 1.038 1.058 <.0001 0.0063 0.0016
Stroke 6,370,430 27,376 0.979 0.997 1.017 0.7930 −0.0004 0.0016
O3 Non-accidental Mortality 7,687,414 132,205 0.983 0.991 1.000 0.0488 −0.0017 0.0009
CVD Mortality 6,342,847 33,085 0.977 0.995 1.014 0.6282 −0.0009 0.0019
Cardiovascular Disease 7,257,889 70,623 0.978 0.989 1.001 0.0640 −0.0022 0.0012
Myocardial Infarction 6,428,266 30,639 0.967 0.984 1.001 0.0672 −0.0032 0.0018
Stroke 6,370,430 27,376 0.950 0.967 0.985 0.0003 −0.0067 0.0019
Reduced
Outcome Person Years Events HR Lower HR Est. HR Upper p Value Parameter Est. Std. Error
PM2.5 Non-accidental Mortality 7,649,109 131,293 1.023 1.033 1.042 <.0001 0.0108 0.0016
CVD Mortality 7,106,288 32,982 1.051 1.073 1.095 <.0001 0.0236 0.0035
Cardiovascular Disease 7,220,320 70,275 1.043 1.056 1.069 <.0001 0.0182 0.0021
Myocardial Infarction 6,391,724 30,512 1.047 1.067 1.087 <.0001 0.0215 0.0032
Stroke 6,335,277 27,260 1.012 1.032 1.052 0.0014 0.0105 0.0033
NO2 Non-accidental Mortality 7,649,109 131,293 1.026 1.035 1.044 <.0001 0.0057 0.0007
CVD Mortality 7,106,288 32,982 1.038 1.059 1.081 <.0001 0.0096 0.0017
Cardiovascular Disease 7,220,320 70,275 1.015 1.027 1.040 <.0001 0.0044 0.0010
Myocardial Infarction 6,391,724 30,512 1.028 1.048 1.067 <.0001 0.0077 0.0016
Stroke 6,335,277 27,260 0.985 1.004 1.023 0.7128 0.0006 0.0016
O3 Non-accidental Mortality 7,649,109 131,293 0.980 0.988 0.997 0.0079 −0.0023 0.0009
CVD Mortality 6,305,845 32,788 0.974 0.993 1.012 0.4487 −0.0015 0.0019
Cardiovascular Disease 7,220,320 70,275 0.973 0.985 0.996 0.0079 −0.0031 0.0012
Myocardial Infarction 6,391,724 30,512 0.961 0.977 0.994 0.0092 −0.0046 0.0018
Stroke 6,335,277 27,260 0.945 0.962 0.980 <.0001 −0.0076 0.0019
Sensitivity 1
Outcome Person Years Events HR Lower HR Est. HR Upper p Value Parameter Est. Std. Error
PM2.5 Non-accidental Mortality 7,702,397 132,279 1.022 1.031 1.041 <.0001 0.0103 0.0016
CVD Mortality 7,157,762 33,297 1.050 1.072 1.094 <.0001 0.0232 0.0035
Cardiovascular Disease 7,273,099 70,688 1.040 1.053 1.066 <.0001 0.0172 0.0021
Myocardial Infarction 6,440,300 30,669 1.040 1.060 1.080 <.0001 0.0194 0.0032
Stroke 6,383,238 27,414 1.010 1.030 1.050 0.0032 0.0097 0.0033
NO2 Non-accidental Mortality 7,702,397 132,279 1.026 1.035 1.045 <.0001 0.0058 0.0007
CVD Mortality 7,157,762 33,297 1.039 1.060 1.082 <.0001 0.0097 0.0017
Cardiovascular Disease 7,460,965 72,416 1.011 1.024 1.036 0.0002 0.0039 0.0010
Myocardial Infarction 6,581,638 31,389 1.022 1.041 1.060 <.0001 0.0067 0.0016
Stroke 6,383,238 27,414 0.982 1.000 1.019 0.9777 0.0000 0.0016
O3 Non-accidental Mortality 7,702,397 132,279 0.979 0.988 0.996 0.0056 −0.0024 0.0009
CVD Mortality 6,352,482 33,103 0.971 0.990 1.009 0.2980 −0.0020 0.0019
Cardiovascular Disease 7,273,099 70,688 0.975 0.986 0.998 0.0197 −0.0027 0.0012
Myocardial Infarction 6,440,300 30,669 0.965 0.982 0.999 0.0372 −0.0037 0.0018
Stroke 6,383,238 27,414 0.947 0.965 0.983 0.0001 −0.0072 0.0019
Sensitivity 2
Outcome Person Years Events HR Lower HR Est. HR Upper p Value Parameter Est. Std. Error
PM2.5 Non-accidental Mortality 2,220,456 21,500 1.001 1.025 1.049 0.0401 0.0082 0.0040
CVD Mortality 1,397,593 4,471 1.013 1.063 1.115 0.0125 0.0203 0.0081
Cardiovascular Disease 2,117,617 10,798 0.985 1.016 1.047 0.3123 0.0053 0.0052
Myocardial Infarction 1,823,711 4,673 0.949 0.993 1.038 0.7445 −0.0025 0.0076
Stroke 1,638,552 5,364 0.956 0.999 1.043 0.9564 −0.0004 0.0074
NO2 Non-accidental Mortality 4,140,847 36,272 1.040 1.061 1.082 <.0001 0.0098 0.0017
CVD Mortality 1,458,383 4,739 1.038 1.083 1.130 0.0002 0.0133 0.0036
Cardiovascular Disease 2,195,400 11,186 0.997 1.024 1.053 0.0852 0.0040 0.0023
Myocardial Infarction 1,823,711 4,673 0.966 1.006 1.048 0.7803 0.0010 0.0035
Stroke 1,638,552 5,364 0.960 0.998 1.038 0.9188 −0.0003 0.0033
O3 Non-accidental Mortality 2,220,456 21,500 0.934 0.957 0.980 0.0003 −0.0088 0.0025
CVD Mortality 1,397,593 4,471 0.896 0.942 0.991 0.0218 −0.0119 0.0052
Cardiovascular Disease 2,117,617 10,798 0.926 0.957 0.989 0.0096 −0.0087 0.0034
Myocardial Infarction 1,823,711 4,673 0.918 0.966 1.016 0.1781 −0.0070 0.0052
Stroke 1,638,552 5,364 0.913 0.957 1.002 0.0612 −0.0089 0.0047
Sensitivity 3
Outcome Person Years Events HR Lower HR Est. HR Upper p Value Parameter Est. Std. Error
PM2.5 Non-accidental Mortality 2,235,439 21,574 1.004 1.028 1.052 0.0201 0.0092 0.0040
CVD Mortality 1,402,410 4,480 1.020 1.069 1.121 0.0056 0.0224 0.0081
Cardiovascular Disease 2,132,828 10,863 0.990 1.020 1.052 0.1932 0.0067 0.0052
Myocardial Infarction 1,835,745 4,703 0.954 0.998 1.044 0.9188 −0.0008 0.0076
Stroke 1,651,360 5,402 0.960 1.003 1.048 0.8897 0.0010 0.0074
NO2 Non-accidental Mortality 2,334,849 22,826 1.044 1.064 1.084 <.0001 0.0103 0.0016
CVD Mortality 1,463,200 4,748 1.045 1.088 1.133 <.0001 0.0141 0.0034
Cardiovascular Disease 2,210,611 11,251 1.005 1.031 1.058 0.0205 0.0051 0.0022
Myocardial Infarction 1,892,030 4,858 0.975 1.014 1.055 0.4811 0.0023 0.0033
Stroke 1,708,569 5,563 0.971 1.008 1.046 0.6837 0.0013 0.0032
O3 Non-accidental Mortality 2,235,439 21,574 0.927 0.949 0.972 <.0001 −0.0104 0.0025
CVD Mortality 1,402,410 4,480 0.888 0.934 0.983 0.0083 −0.0137 0.0052
Cardiovascular Disease 2,132,828 10,863 0.922 0.953 0.984 0.0039 −0.0097 0.0034
Myocardial Infarction 1,835,745 4,703 0.913 0.960 1.010 0.1132 −0.0082 0.0052
Stroke 1,651,360 5,402 0.911 0.954 0.999 0.0461 −0.0094 0.0047