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## +.gg ggplot2## Welcome! Want to learn more? See two factoextra-related books at https://goo.gl/ve3WBa## Warning: package 'FactoMineR' was built under R version 4.1.3## Warning: package 'visdat' was built under R version 4.1.3## Warning: package 'readxl' was built under R version 4.1.3Se desea caracterizar el perfil de citoquinas en plasma de mujeres embarazadas, crónicamente infectadas por T. cruzi y su asociación con la transmisión vertical en una cohorte de la provincia de Salta
Se obtuvieron muestras de plasma de mujeres embarazadas (2do trimestre) con infección crónica de Chagas residentes en la provincia de Salta. Se registraron datos clínicos y niveles de citoquinas en plasma: IL-12p70, IL-10, TNF-α, IL-15, IL-17A y IL-6 (en pg/ml)
Se definieron los siguiente sgrupos: • E+B-: Embarazada infectada con T. cruzi y cuyo hijo nació sin infección (sin transmisión vertical) • E+B+: Embarazada infectada con T. cruzi y cuyo hijo nació con infección (con transmisión vertical) • E-: Embarazada no infectada con T. cruzi
| E- (N=5) | E+B- (N=34) | E+B+ (N=9) | Total (N=48) | p value | |
|---|---|---|---|---|---|
| Edad | 0.033 | ||||
| Mean (SD) | 23.800 (5.805) | 31.618 (5.668) | 29.889 (7.590) | 30.479 (6.401) | |
| Range | 18.000 - 33.000 | 18.000 - 41.000 | 23.000 - 43.000 | 18.000 - 43.000 | |
| Tipo.de.parto | 0.847 | ||||
| cesárea | 1 (20.0%) | 11 (32.4%) | 3 (33.3%) | 15 (31.2%) | |
| espontáneo | 4 (80.0%) | 23 (67.6%) | 6 (66.7%) | 33 (68.8%) | |
| Clasificación.según.EG | 0.517 | ||||
| pretérmino | 0 (0.0%) | 3 (8.8%) | 0 (0.0%) | 3 (6.2%) | |
| término | 5 (100.0%) | 31 (91.2%) | 9 (100.0%) | 45 (93.8%) | |
| Hb | 0.743 | ||||
| Mean (SD) | 11.760 (1.854) | 11.579 (1.387) | 11.233 (1.021) | 11.533 (1.358) | |
| Range | 9.300 - 14.000 | 8.100 - 14.100 | 10.000 - 12.500 | 8.100 - 14.100 | |
| Anemia | 0.674 | ||||
| Mean (SD) | 0.400 (0.548) | 0.294 (0.462) | 0.444 (0.527) | 0.333 (0.476) | |
| Range | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | |
| Titulo_toxo | 0.144 | ||||
| Mean (SD) | 0.000 (0.000) | 47.244 (109.719) | 388.931 (1092.342) | 106.389 (480.181) | |
| Range | 0.000 - 0.000 | 0.000 - 490.000 | 0.000 - 3300.000 | 0.000 - 3300.000 | |
| Sexo.RN | 0.629 | ||||
| mujer | 1 (20.0%) | 14 (41.2%) | 4 (44.4%) | 19 (39.6%) | |
| varón | 4 (80.0%) | 20 (58.8%) | 5 (55.6%) | 29 (60.4%) | |
| Peso_RN_categ | 0.810 | ||||
| Bajo peso | 0 (0.0%) | 1 (2.9%) | 0 (0.0%) | 1 (2.1%) | |
| Normopeso | 5 (100.0%) | 33 (97.1%) | 9 (100.0%) | 47 (97.9%) | |
| Peso..g. | 0.825 | ||||
| Mean (SD) | 3318.000 (181.301) | 3356.765 (357.870) | 3424.444 (337.939) | 3365.417 (336.332) | |
| Range | 3060.000 - 3530.000 | 2320.000 - 4110.000 | 2790.000 - 3780.000 | 2320.000 - 4110.000 | |
| Apgar | 0.489 | ||||
| Deprimido | 0 (0.0%) | 1 (2.9%) | 1 (11.1%) | 2 (4.2%) | |
| Vigoroso | 5 (100.0%) | 33 (97.1%) | 8 (88.9%) | 46 (95.8%) | |
| Comorbilidades | 0.302 | ||||
| Mean (SD) | 0.000 (0.000) | 0.265 (0.448) | 0.111 (0.333) | 0.208 (0.410) | |
| Range | 0.000 - 0.000 | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | |
| obesidad | 0.567 | ||||
| Mean (SD) | 0.000 (0.000) | 0.176 (0.387) | 0.111 (0.333) | 0.146 (0.357) | |
| Range | 0.000 - 0.000 | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | |
| Toxo | 0.123 | ||||
| Mean (SD) | 0.000 (0.000) | 0.412 (0.500) | 0.556 (0.527) | 0.396 (0.494) | |
| Range | 0.000 - 0.000 | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | |
| Enf.propias.del.emb | 0.109 | ||||
| Mean (SD) | 0.200 (0.447) | 0.500 (0.508) | 0.778 (0.441) | 0.521 (0.505) | |
| Range | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | |
| Aborto | 0.421 | ||||
| Mean (SD) | 0.400 (0.548) | 0.471 (0.507) | 0.222 (0.441) | 0.417 (0.498) | |
| Range | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | 0.000 - 1.000 | |
| Paridad | 0.059 | ||||
| Nulipara | 3 (60.0%) | 5 (14.7%) | 4 (44.4%) | 12 (25.0%) | |
| Primípara | 1 (20.0%) | 7 (20.6%) | 0 (0.0%) | 8 (16.7%) | |
| Secundípara | 1 (20.0%) | 9 (26.5%) | 0 (0.0%) | 10 (20.8%) | |
| Multípara | 0 (0.0%) | 13 (38.2%) | 5 (55.6%) | 18 (37.5%) | |
| Otros.hijos.positivos | 0.004 | ||||
| Mean (SD) | 0.000 (0.000) | 0.912 (0.452) | 1.111 (1.054) | 0.854 (0.652) | |
| Range | 0.000 - 0.000 | 0.000 - 2.000 | 0.000 - 2.000 | 0.000 - 2.000 | |
| Etiología.de.Chagas.Materno | < 0.001 | ||||
| Mean (SD) | 0.200 (0.447) | 1.147 (0.359) | 1.000 (0.000) | 1.021 (0.437) | |
| Range | 0.000 - 1.000 | 1.000 - 2.000 | 1.000 - 1.000 | 0.000 - 2.000 | |
| Tto.previo.en.la.madre | 0.256 | ||||
| Mean (SD) | 0.000 (0.000) | 0.176 (0.387) | 0.000 (0.000) | 0.125 (0.334) | |
| Range | 0.000 - 0.000 | 0.000 - 1.000 | 0.000 - 0.000 | 0.000 - 1.000 |
| E- (N=5) | E+B- (N=34) | E+B+ (N=9) | Total (N=48) | p value | |
|---|---|---|---|---|---|
| IL.12p70 | < 0.001 | ||||
| N-Miss | 0 | 1 | 0 | 1 | |
| Mean (SD) | 86.298 (23.388) | 44.431 (16.995) | 46.275 (14.707) | 49.238 (21.300) | |
| Range | 65.904 - 123.629 | 17.269 - 76.092 | 25.672 - 66.185 | 17.269 - 123.629 | |
| IL.15 | 0.196 | ||||
| N-Miss | 2 | 1 | 0 | 3 | |
| Mean (SD) | 16.207 (8.475) | 38.036 (22.765) | 61.575 (84.335) | 41.289 (42.525) | |
| Range | 8.650 - 25.370 | 3.830 - 115.170 | 11.830 - 285.070 | 3.830 - 285.070 | |
| IL.17A | 0.475 | ||||
| N-Miss | 1 | 2 | 0 | 3 | |
| Mean (SD) | 68.401 (8.683) | 63.680 (11.544) | 68.902 (16.762) | 65.144 (12.471) | |
| Range | 61.076 - 80.503 | 45.308 - 94.099 | 51.681 - 101.132 | 45.308 - 101.132 | |
| IL.10 | 0.052 | ||||
| N-Miss | 3 | 12 | 1 | 16 | |
| Mean (SD) | 37.919 (3.992) | 57.967 (15.066) | 64.466 (5.834) | 58.338 (14.094) | |
| Range | 35.097 - 40.742 | 24.452 - 83.803 | 56.880 - 73.761 | 24.452 - 83.803 | |
| IL.6 | 0.859 | ||||
| N-Miss | 1 | 6 | 3 | 10 | |
| Mean (SD) | 31.571 (11.547) | 39.046 (37.190) | 45.193 (52.051) | 39.230 (37.395) | |
| Range | 21.495 - 47.758 | 11.433 - 153.641 | 14.790 - 150.284 | 11.433 - 153.641 | |
| TNF | 0.936 | ||||
| N-Miss | 3 | 10 | 2 | 15 | |
| Mean (SD) | 21.030 (8.338) | 20.042 (15.247) | 22.361 (14.795) | 20.594 (14.534) | |
| Range | 15.134 - 26.925 | 5.955 - 75.223 | 5.159 - 51.656 | 5.159 - 75.223 |
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