Table 1. Demographics of Aging Cohorts
Clinical Cohorts
Healthy Aging Discovery Healthy Aging Validation Amyloid Aging Exploratory
Sample Information
Sample Type CSF CSF CSF
Center UCSF WashU WashU
Platform SOMAscan7k/Quanterix SOMAscan7k SOMAscan7k
Demographics
N 70 653 752
Age (years) 71.7 ± 7.6 (53.4-90.6) 69.3 ± 8.6 (37.0-91.0) 73.6 ± 7.6 (37.0-91.0)
% Male 60.0 46.4 53.2
% APOE4 30.0 - -
% Amyloid Positive - 0.0 100.0
% Tau Positive - 0.0 51.7
Clinical Measures
MMSE Score 29.0 ± 1.3 (25.0-30.0) - -
CDR Box - -
Metabolic Measures
Lab Number 1.8 ± 1.2 (1.0-5.0) [20 missing] - -
HOMA-IR 1.9 ± 1.5 (0.3-8.1) [22 missing] - -
Glucose (mg/dL) 93.9 ± 10.8 (77.0-134.0) [22 missing] - -
HbA1c (%) 5.4 ± 0.4 (4.8-6.7) [20 missing] - -
Insulin (µU/mL) 8.2 ± 5.4 (1.5-32.3) [20 missing] - -
Total Cholesterol (mg/dL) 201.0 ± 37.5 (130.0-294.0) [22 missing] - -
Triglycerides (mg/dL) 85.0 ± 41.1 (28.0-201.0) [22 missing] - -
HDL (mg/dL) 64.0 ± 19.1 (31.0-120.0) [22 missing] - -
LDL (mg/dL) 120.0 ± 31.6 (66.0-217.0) [22 missing] - -
hsCRP (mg/L) 2.6 ± 4.6 (0.1-30.3) [21 missing] - -
Cholesterol/HDL Ratio 3.4 ± 1.1 (2.0-7.0) [22 missing] - -
Non-HDL Cholesterol (mg/dL) 137.0 ± 33.4 (73.0-252.0) [22 missing] - -