☆ Objective

This study aims to assess and compare the variance and mean effects of metabolic traits between CSS10 and B6 mice, as well as between CSS17 and B6 mice. The metabolic traits include body weight, body length, glucose levels, BMI measured at different time points, and liver weight along with normalized liver weight at the time of sacrifice. The null hypothesis is neither of the two CSS strains mice (CSS10 & CSS17) will differ significantly from the B6 reference strain for any trait, whether considering central tendency or dispersion.

☆ Density Plot

☆ Skewness & Kurtosis

The Cullen and Frey graphs depict skewness and kurtosis for all traits in the three mouse strains.

☆ Sample Statistics

Cells highlighted in pink indicate that the Jarque-Bera normality test p-value is greater than 0.05, suggesting a normal distribution. If the cells are empty, this indicates a failure of the bimodality test using GmixR.

☆ Basic Comparison

☆ Variance Effect

The green-highlighted cells indicate p-values less than 0.05. For the permutation test (indicated by an asterisk in front of the column), we used 1000 permutations. If you observe a value of 0 in these columns, it signifies a p-value of less than 1/1000.

☆ Mean Effect

The green-highlighted cells indicate p-values less than 0.05. For the permutation test (indicated by an asterisk in front of the column), we used 1000 permutations. If you observe a value of 0 in these columns, it signifies a p-value of less than 1/1000.