Characteristic Comparator, N = 5611 Elevated SSA, N = 501 Estimand 95% CI p-value
Age (years) 52.8 (9.8) 51.1 (10.2)
Gender (female) 294 (52%) 41 (82%)
Time to follow up (years) 12.1 (1.2) 12.2 (1.0)
Total number of conditions 1.7 (1.7) 2.2 (1.8)
    Asthma 54 (9.6%) 6 (12%)
    COPD 8 (1.4%) 2 (4.0%)
    Heart disease 40 (7.1%) 3 (6.0%)
    Hypertension 131 (23%) 13 (26%)
    Hyperlipidemia 220 (39%) 20 (40%)
    Anemia 64 (11%) 8 (16%)
    Thrombosis 19 (3.4%) 3 (6.0%)
    TIA/Stroke 13 (2.3%) 3 (6.0%)
    Peptic ulcer disease 16 (2.9%) 5 (10%)
    Cirrhosis/Liver disease 7 (1.2%) 0 (0%)
    Diabetes 43 (7.7%) 0 (0%)
    Thyroid disease 65 (12%) 9 (18%)
    Cancer 61 (11%) 0 (0%)
    Arthritis 120 (21%) 14 (28%)
    Glaucoma 11 (2.0%) 2 (4.0%)
    Depression 77 (14%) 20 (40%)
Number of prescription medications2 3.7 (3.3) 5.2 (4.7) 1.3 0.4, 2.2 0.006
Polypharmacy3 186 (33%) 26 (52%) 2.2 1.1, 4.4 0.024
1 Mean (SD); n (%)
2 Linear regression (Estimand = beta) adjusting for age, gender, time to follow up, and total number of conditions
3 Logistic regression (Estimand = OR) adjusting for age, gender, time to follow up, and total number of conditions