#Table 1

table1(~Gender_Legal_Sex+age_10year+htn+dm+cad+chf+copd+nsaid+beta_blockers+statins+ace_arb+ppi+diur+immunosuppressant+vaccine_ACTUAL+renal_group2+cancer+pre_cre_freq_cat+pre_inpt_freq_cat+new_renal_outcome_status+new_dm_outcome_status+new_cv_outcome_status+sglt2i+ccb+statins+
                   pre_HGB_365days_cat+pre_ALB_365days_cat+pre_WBC_365days_cat+pre_sodium_365days_cat+pre_potassium_365days_cat+pre_urine_proetein_ratio_365days_cat|case,data=matched_final)
0
(N=840)		 1
(N=840)		 Overall
(N=1680)
Gender_Legal_Sex
Female 450 (53.6%) 430 (51.2%) 880 (52.4%)
Male 390 (46.4%) 410 (48.8%) 800 (47.6%)
age_10year
Mean (SD) 7.34 (1.33) 7.32 (1.33) 7.33 (1.33)
Median [Min, Max] 7.50 [2.15, 10.0] 7.50 [2.18, 10.4] 7.50 [2.15, 10.4]
htn
0 130 (15.5%) 128 (15.2%) 258 (15.4%)
1 710 (84.5%) 712 (84.8%) 1422 (84.6%)
dm
0 446 (53.1%) 432 (51.4%) 878 (52.3%)
1 394 (46.9%) 408 (48.6%) 802 (47.7%)
cad
0 383 (45.6%) 407 (48.5%) 790 (47.0%)
1 457 (54.4%) 433 (51.5%) 890 (53.0%)
chf
0 751 (89.4%) 752 (89.5%) 1503 (89.5%)
1 89 (10.6%) 88 (10.5%) 177 (10.5%)
copd
0 689 (82.0%) 697 (83.0%) 1386 (82.5%)
1 151 (18.0%) 143 (17.0%) 294 (17.5%)
nsaid
0 673 (80.1%) 675 (80.4%) 1348 (80.2%)
1 167 (19.9%) 165 (19.6%) 332 (19.8%)
beta_blockers
0 495 (58.9%) 483 (57.5%) 978 (58.2%)
1 345 (41.1%) 357 (42.5%) 702 (41.8%)
statins
0 424 (50.5%) 420 (50.0%) 844 (50.2%)
1 416 (49.5%) 420 (50.0%) 836 (49.8%)
ace_arb
0 515 (61.3%) 498 (59.3%) 1013 (60.3%)
1 325 (38.7%) 342 (40.7%) 667 (39.7%)
ppi
0 568 (67.6%) 568 (67.6%) 1136 (67.6%)
1 272 (32.4%) 272 (32.4%) 544 (32.4%)
diur
0 530 (63.1%) 524 (62.4%) 1054 (62.7%)
1 310 (36.9%) 316 (37.6%) 626 (37.3%)
immunosuppressant
0 792 (94.3%) 796 (94.8%) 1588 (94.5%)
1 48 (5.7%) 44 (5.2%) 92 (5.5%)
vaccine_ACTUAL
0 126 (15.0%) 113 (13.5%) 239 (14.2%)
1 714 (85.0%) 727 (86.5%) 1441 (85.8%)
renal_group2
eGFR <30, no ESKD 58 (6.9%) 54 (6.4%) 112 (6.7%)
eGFR 30-44.9, no ESKD 177 (21.1%) 194 (23.1%) 371 (22.1%)
eGFR 45-59.9, no ESKD 506 (60.2%) 498 (59.3%) 1004 (59.8%)
ESKD 99 (11.8%) 94 (11.2%) 193 (11.5%)
cancer
0 473 (56.3%) 486 (57.9%) 959 (57.1%)
1 367 (43.7%) 354 (42.1%) 721 (42.9%)
pre_cre_freq_cat
1 181 (21.5%) 176 (21.0%) 357 (21.3%)
2-4 659 (78.5%) 664 (79.0%) 1323 (78.8%)
pre_inpt_freq_cat
0 617 (73.5%) 621 (73.9%) 1238 (73.7%)
1-2 124 (14.8%) 118 (14.0%) 242 (14.4%)
3+ 99 (11.8%) 101 (12.0%) 200 (11.9%)
new_renal_outcome_status
Mean (SD) 0.0595 (0.237) 0.0345 (0.183) 0.0470 (0.212)
Median [Min, Max] 0 [0, 1.00] 0 [0, 1.00] 0 [0, 1.00]
new_dm_outcome_status
Mean (SD) 0.0310 (0.173) 0.0202 (0.141) 0.0256 (0.158)
Median [Min, Max] 0 [0, 1.00] 0 [0, 1.00] 0 [0, 1.00]
new_cv_outcome_status
Mean (SD) 0.183 (0.387) 0.181 (0.385) 0.182 (0.386)
Median [Min, Max] 0 [0, 1.00] 0 [0, 1.00] 0 [0, 1.00]
sglt2i
0 801 (95.4%) 791 (94.2%) 1592 (94.8%)
1 39 (4.6%) 49 (5.8%) 88 (5.2%)
ccb
0 582 (69.3%) 580 (69.0%) 1162 (69.2%)
1 258 (30.7%) 260 (31.0%) 518 (30.8%)
pre_HGB_365days_cat
Missing 40 (4.8%) 82 (9.8%) 122 (7.3%)
Q1 200 (23.8%) 192 (22.9%) 392 (23.3%)
Q2 204 (24.3%) 187 (22.3%) 391 (23.3%)
Q3 174 (20.7%) 189 (22.5%) 363 (21.6%)
Q4 222 (26.4%) 190 (22.6%) 412 (24.5%)
pre_ALB_365days_cat
Missing 136 (16.2%) 119 (14.2%) 255 (15.2%)
Q1 162 (19.3%) 261 (31.1%) 423 (25.2%)
Q2 179 (21.3%) 154 (18.3%) 333 (19.8%)
Q3 212 (25.2%) 183 (21.8%) 395 (23.5%)
Q4 151 (18.0%) 123 (14.6%) 274 (16.3%)
pre_WBC_365days_cat
Missing 40 (4.8%) 82 (9.8%) 122 (7.3%)
Q1 191 (22.7%) 233 (27.7%) 424 (25.2%)
Q2 189 (22.5%) 166 (19.8%) 355 (21.1%)
Q3 209 (24.9%) 167 (19.9%) 376 (22.4%)
Q4 211 (25.1%) 192 (22.9%) 403 (24.0%)
pre_sodium_365days_cat
Missing 7 (0.8%) 5 (0.6%) 12 (0.7%)
Q1 237 (28.2%) 293 (34.9%) 530 (31.5%)
Q2 211 (25.1%) 197 (23.5%) 408 (24.3%)
Q3 221 (26.3%) 205 (24.4%) 426 (25.4%)
Q4 164 (19.5%) 140 (16.7%) 304 (18.1%)
pre_potassium_365days_cat
Missing 12 (1.4%) 15 (1.8%) 27 (1.6%)
Q1 224 (26.7%) 234 (27.9%) 458 (27.3%)
Q2 204 (24.3%) 196 (23.3%) 400 (23.8%)
Q3 198 (23.6%) 209 (24.9%) 407 (24.2%)
Q4 202 (24.0%) 186 (22.1%) 388 (23.1%)
pre_urine_proetein_ratio_365days_cat
<=0.1 14 (1.7%) 4 (0.5%) 18 (1.1%)
>0.1 30 (3.6%) 19 (2.3%) 49 (2.9%)
Not checked 796 (94.8%) 817 (97.3%) 1613 (96.0%)

Univariate coxph hosp_outcome 30 days

Characteristic N HR1 95% CI1 p-value
age_bl 157 1.0 0.98, 1.01 0.446
group 157
    control — —
    case_no_vaccine 0.54 0.35, 0.82 0.004
    case_vaccine 0.47 0.33, 0.68 <0.001
Gender_Legal_Sex 157
    Female — —
    Male 0.98 0.71, 1.35 0.894
htn 157
    0 — —
    1 0.68 0.40, 1.15 0.150
dm 157
    0 — —
    1 0.77 0.56, 1.05 0.096
copd 157
    0 — —
    1 1.06 0.73, 1.55 0.753
cad 157
    0 — —
    1 0.86 0.62, 1.20 0.377
chf 157
    0 — —
    1 1.20 0.79, 1.81 0.398
subclass 157 1.00 1.00, 1.00 0.599
1 HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph hosp_outcome 30 days

Characteristic N HR1 95% CI1 p-value
age_bl 157 1.00 0.99, 1.02 0.716
group 157
    control — —
    case_no_vaccine 0.56 0.35, 0.90 0.016
    case_vaccine 0.48 0.33, 0.69 <0.001
Gender_Legal_Sex 157
    Female — —
    Male 0.93 0.66, 1.30 0.652
htn 157
    0 — —
    1 0.96 0.46, 2.04 0.921
dm 157
    0 — —
    1 0.75 0.54, 1.05 0.094
copd 157
    0 — —
    1 1.03 0.69, 1.54 0.892
cad 157
    0 — —
    1 0.86 0.59, 1.26 0.445
chf 157
    0 — —
    1 1.37 0.91, 2.06 0.137
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate coxph death 30 days

Characteristic N HR1 95% CI1 p-value
age_bl 1,680 1.07 1.02, 1.11 0.005
group 1,680
    control — —
    case_no_vaccine 18.5 6.53, 52.6 <0.001
    case_vaccine 2.79 0.98, 7.96 0.056
Gender_Legal_Sex 1,680
    Female — —
    Male 1.18 0.57, 2.45 0.657
htn 1,680
    0 — —
    1 0.57 0.24, 1.32 0.187
dm 1,680
    0 — —
    1 0.67 0.32, 1.40 0.286
cad 1,680
    0 — —
    1 1.26 0.60, 2.63 0.538
chf 1,680
    0 — —
    1 0.63 0.15, 2.66 0.529
copd 1,680
    0 — —
    1 2.13 0.97, 4.66 0.059
subclass 1,680 1.00 1.00, 1.00 0.059
1 HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph death 30 days

Characteristic N HR1 95% CI1 p-value
age_bl 1,680 1.07 1.02, 1.11 0.002
group 1,680
    control — —
    case_no_vaccine 22.7 8.07, 64.0 <0.001
    case_vaccine 2.86 1.01, 8.09 0.048
Gender_Legal_Sex 1,680
    Female — —
    Male 1.23 0.57, 2.64 0.602
htn 1,680
    0 — —
    1 0.42 0.19, 0.95 0.038
dm 1,680
    0 — —
    1 0.69 0.29, 1.59 0.380
copd 1,680
    0 — —
    1 2.69 1.14, 6.38 0.024
cad 1,680
    0 — —
    1 1.65 0.82, 3.31 0.159
chf 1,680
    0 — —
    1 0.53 0.11, 2.51 0.422
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate logistic regression critical illness 30 days hospitalized

## Registered S3 method overwritten by 'gdata':
##   method         from     
##   reorder.factor DescTools
## 
##  
##    Cell Contents
## |-------------------------|
## |                       N |
## | Chi-square contribution |
## |           N / Row Total |
## |           N / Col Total |
## |         N / Table Total |
## |-------------------------|
## 
##  
## Total Observations in Table:  75 
## 
##  
##                                       | matched_final$group 
## matched_final$Critical_illness_30days |         control | case_no_vaccine |    case_vaccine |       Row Total | 
## --------------------------------------|-----------------|-----------------|-----------------|-----------------|
##                                     0 |               0 |              10 |              53 |              63 | 
##                                       |             NaN |           0.078 |           0.016 |                 | 
##                                       |           0.000 |           0.159 |           0.841 |           0.840 | 
##                                       |             NaN |           0.769 |           0.855 |                 | 
##                                       |           0.000 |           0.133 |           0.707 |                 | 
## --------------------------------------|-----------------|-----------------|-----------------|-----------------|
##                                     1 |               0 |               3 |               9 |              12 | 
##                                       |             NaN |           0.407 |           0.085 |                 | 
##                                       |           0.000 |           0.250 |           0.750 |           0.160 | 
##                                       |             NaN |           0.231 |           0.145 |                 | 
##                                       |           0.000 |           0.040 |           0.120 |                 | 
## --------------------------------------|-----------------|-----------------|-----------------|-----------------|
##                          Column Total |               0 |              13 |              62 |              75 | 
##                                       |           0.000 |           0.173 |           0.827 |                 | 
## --------------------------------------|-----------------|-----------------|-----------------|-----------------|
## 
##
Characteristic N OR1 95% CI1 p-value
age_bl 75 1.03 0.97, 1.09 0.389
vaccine_ACTUAL 75
    0 — —
    1 0.57 0.14, 2.88 0.448
Gender_Legal_Sex 75
    Female — —
    Male 1.03 0.29, 3.63 0.960
htn 75
    0 — —
    1 0.25 0.04, 2.07 0.155
dm 75
    0 — —
    1 0.66 0.19, 2.32 0.508
cad 75
    0 — —
    1 0.81 0.23, 2.99 0.735
chf 75
    0 — —
    1 1.20 0.17, 5.60 0.831
copd 75
    0 — —
    1 0.98 0.20, 3.77 0.977
1 OR = Odds Ratio, CI = Confidence Interval

Multvariate logistic regression critical illness 30 days hospitalized

Characteristic N OR1 95% CI1 p-value
age_bl 75 1.05 0.99, 1.12 0.122
vaccine_ACTUAL 75
    0 — —
    1 0.48 0.08, 3.08 0.407
Gender_Legal_Sex 75
    Female — —
    Male 1.28 0.30, 5.80 0.741
htn 75
    0 — —
    1 0.12 0.01, 1.45 0.084
dm 75
    0 — —
    1 0.76 0.20, 2.91 0.685
cad 75
    0 — —
    1 0.74 0.16, 3.64 0.706
chf 75
    0 — —
    1 2.13 0.26, 13.3 0.432
copd 75
    0 — —
    1 1.21 0.22, 5.56 0.813
1 OR = Odds Ratio, CI = Confidence Interval

Univariate coxph new_renal_outcome

Characteristic N HR1 95% CI1 p-value
age_bl 1,487 1.00 0.98, 1.02 0.772
group 1,487
    control — —
    case_no_vaccine 0.90 0.38, 2.12 0.804
    case_vaccine 0.52 0.32, 0.85 0.009
Gender_Legal_Sex 1,487
    Female — —
    Male 1.12 0.72, 1.73 0.620
htn 1,487
    0 — —
    1 1.78 0.85, 3.70 0.124
dm 1,487
    0 — —
    1 1.34 0.87, 2.06 0.180
cad 1,487
    0 — —
    1 1.24 0.80, 1.92 0.346
chf 1,487
    0 — —
    1 1.56 0.84, 2.91 0.158
copd 1,487
    0 — —
    1 1.54 0.94, 2.54 0.089
subclass 1,487 1.00 1.00, 1.00 0.625
1 HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph new_renal_outcome

Characteristic N HR1 95% CI1 p-value
age_bl 1,487 1.00 0.98, 1.02 0.874
group 1,487
    control — —
    case_no_vaccine 0.96 0.41, 2.27 0.930
    case_vaccine 0.51 0.31, 0.83 0.007
Gender_Legal_Sex 1,487
    Female — —
    Male 1.14 0.73, 1.79 0.560
htn 1,487
    0 — —
    1 1.60 0.68, 3.72 0.280
dm 1,487
    0 — —
    1 1.19 0.74, 1.92 0.478
cad 1,487
    0 — —
    1 0.97 0.59, 1.59 0.911
chf 1,487
    0 — —
    1 1.32 0.67, 2.57 0.421
copd 1,487
    0 — —
    1 1.46 0.86, 2.48 0.161
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate coxph new_dm_outcome

Characteristic N HR1 95% CI1 p-value
age_bl 1,680 0.98 0.96, 1.00 0.070
group 1,680
    control — —
    case_no_vaccine 0.57 0.13, 2.40 0.441
    case_vaccine 0.66 0.35, 1.24 0.198
Gender_Legal_Sex 1,680
    Female — —
    Male 1.05 0.57, 1.93 0.881
htn 1,680
    0 — —
    1 1.78 0.64, 4.98 0.270
cad 1,680
    0 — —
    1 0.84 0.46, 1.56 0.586
chf 1,680
    0 — —
    1 1.97 0.85, 4.55 0.112
copd 1,680
    0 — —
    1 1.25 0.61, 2.56 0.544
subclass 1,680 1.00 1.00, 1.00 0.116
1 HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph new_dm_outcome

Characteristic N HR1 95% CI1 p-value
age_bl 1,680 0.98 0.96, 1.00 0.047
group 1,680
    control — —
    case_no_vaccine 0.58 0.14, 2.44 0.456
    case_vaccine 0.65 0.35, 1.22 0.180
Gender_Legal_Sex 1,680
    Female — —
    Male 1.07 0.58, 1.97 0.819
htn 1,680
    0 — —
    1 2.18 0.72, 6.66 0.170
cad 1,680
    0 — —
    1 0.64 0.32, 1.31 0.222
chf 1,680
    0 — —
    1 2.30 0.87, 6.10 0.095
copd 1,680
    0 — —
    1 1.23 0.58, 2.61 0.582
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate coxph new_cv_outcome

Characteristic N HR1 95% CI1 p-value
age_bl 1,680 1.01 1.00, 1.02 0.011
group 1,680
    control — —
    case_no_vaccine 1.18 0.77, 1.82 0.444
    case_vaccine 0.96 0.76, 1.22 0.745
Gender_Legal_Sex 1,680
    Female — —
    Male 1.08 0.86, 1.36 0.497
htn 1,680
    0 — —
    1 2.27 1.50, 3.43 <0.001
dm 1,680
    0 — —
    1 1.77 1.41, 2.22 <0.001
copd 1,680
    0 — —
    1 1.74 1.33, 2.26 <0.001
subclass 1,680 1.00 1.00, 1.00 0.178
1 HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph new_cv_outcome

Characteristic N HR1 95% CI1 p-value
age_bl 1,680 1.01 1.00, 1.02 0.085
group 1,680
    control — —
    case_no_vaccine 1.32 0.86, 2.03 0.199
    case_vaccine 0.93 0.74, 1.18 0.568
Gender_Legal_Sex 1,680
    Female — —
    Male 1.08 0.87, 1.36 0.479
htn 1,680
    0 — —
    1 1.66 1.07, 2.58 0.024
dm 1,680
    0 — —
    1 1.58 1.24, 2.00 <0.001
copd 1,680
    0 — —
    1 1.56 1.19, 2.04 0.001
1 HR = Hazard Ratio, CI = Confidence Interval