DVCID
Mark Sanderson-cimino
2024-11-14
Memory score description
Histograms
Presents (a) histogram of UDS3M+ and (b) histograms by CDR Global (0
or .5). It is normally distributed. The scale is based on the
development sample, which included impaired individuals. As a result,
the UDS3M+ within DVCID has a positive mean (.68), and ranges from -1.4
to 2.7. The mean in the original sample is 0 and ranges from about -3 to
3.
## vars n mean sd median trimmed mad min max range skew kurtosis se
## X1 1 459 1.02 0.72 1 1.02 0.71 -1.25 3.07 4.32 0.05 0.18 0.03Memory score by task
CERAD UDS3M+ is much lower than other tasks. Does not seem to be because of age, edu, moca total, % demented, CDR, language, WMHs. At this point I believe that the lower CERAD scores are might be due to a specific site(s), but I do not have site information. The graph is in English speaking participants only.
##
##
## Table: UDS3M+ predicted by Task. All groups are compared to CERAD
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:---------------|---------:|----------:|--------:|-------:|
## |(Intercept) | 0.6067959| 0.0971612| 6.245250| 0.0e+00|
## |CVLT16 vs CERAD | 0.6206586| 0.1212305| 5.119659| 5.0e-07|
## |HVLT vs CERAD | 0.5075660| 0.1079029| 4.703915| 3.5e-06|
## |RAVLT vs CERAD | 0.5807776| 0.1274475| 4.556995| 6.9e-06|##
##
## Table: UDS3M+ predicted by task, controling for age, sex, education, cdr sum of boxes (English only)
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:---------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 0.9200502| 0.4393275| 2.094224| 0.0368611|
## |CVLT16 vs CERAD | 0.6080065| 0.1090234| 5.576842| 0.0000000|
## |HVLT vs CERAD | 0.4943626| 0.0966054| 5.117339| 0.0000005|
## |RAVLT vs CERAD | 0.5893266| 0.1136355| 5.186115| 0.0000003|
## |age | -0.0120596| 0.0050262| -2.399335| 0.0168759|
## |Sex (F) | 0.1963333| 0.0642228| 3.057067| 0.0023833|
## |CDRSUM | -0.3556553| 0.0433785| -8.198878| 0.0000000|
## |EDUC | 0.0377479| 0.0125266| 3.013411| 0.0027456|##
##
## Table: UDS3M+ predicted by task, controling for age, sex, cdr sum of boxes, education, AND Ptau181 (English only)
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:---------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 0.7478981| 0.4407733| 1.696786| 0.0905073|
## |CVLT16 vs CERAD | 0.5919011| 0.1083746| 5.461620| 0.0000001|
## |HVLT vs CERAD | 0.4606222| 0.0967101| 4.762916| 0.0000027|
## |RAVLT vs CERAD | 0.5789201| 0.1128515| 5.129926| 0.0000005|
## |age | -0.0092746| 0.0050964| -1.819842| 0.0695230|
## |Sex (F) | 0.1607962| 0.0651151| 2.469413| 0.0139460|
## |CDRSUM | -0.3427037| 0.0433258| -7.909931| 0.0000000|
## |ptau181_scale | -0.1002415| 0.0375248| -2.671338| 0.0078604|
## |EDUC | 0.0380001| 0.0124332| 3.056354| 0.0023892|Langauge
There are 43 participants with Spanish as their primary language and 415 with English. The Spanish speaking group has significantly lower UDS3M+ scores; this difference is somewhat attenuated (beta = -.67 vs -.57) when controlling for various covariates (age, education, sex, cdr sb). Below are (a) histogram of score by language; (b, c) regressions; the formula is printed first, followed by the output. NPSYLAN = language.
## [1] "English description"## vars n mean sd median trimmed mad min max range skew kurtosis se
## X1 1 415 1.09 0.7 1.04 1.08 0.67 -1.13 3.06 4.19 0.07 0.09 0.03## [1] "Spanish description"## vars n mean sd median trimmed mad min max range skew kurtosis se
## X1 1 43 0.3 0.61 0.49 0.36 0.47 -1.3 1.41 2.7 -0.88 0.39 0.09
##
##
## Table: UDS3M+ predicated by language (English vs Spanish)
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|--------:|------:|
## |(Intercept) | 1.0904096| 0.0340818| 31.99393| 0|
## |Language (Spanish) | -0.7895259| 0.1112297| -7.09816| 0|##
##
## Table: UDS3M+ predicted by langauge, controling for age, sex, edu, cdr sum of boxes
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 1.3101860| 0.4120370| 3.179778| 0.0015756|
## |Language (Spanish) | -0.6748720| 0.1075585| -6.274464| 0.0000000|
## |Sex (F) | 0.1518377| 0.0632347| 2.401176| 0.0167473|
## |age | -0.0123681| 0.0048618| -2.543946| 0.0112941|
## |EDUC | 0.0462402| 0.0121981| 3.790774| 0.0001706|
## |CDRSUM | -0.3551532| 0.0428023| -8.297518| 0.0000000|Site
New results here. Still finalizing. This is just basic setup.
Cerad
HVLT
ravlt
cvlt-16
Deeper dive into CERAD
| cerad | cvlt-16 | hvlt | ravlt | p | test | |
|---|---|---|---|---|---|---|
| n | 49 | 88 | 210 | 68 | ||
| UDS3M (mean (SD)) | 0.61 (0.57) | 1.23 (0.66) | 1.11 (0.69) | 1.19 (0.74) | <0.001 | |
| CDRSUM (mean (SD)) | 0.34 (0.72) | 0.38 (0.77) | 0.36 (0.71) | 0.41 (0.61) | 0.938 | |
| age (mean (SD)) | 76.39 (6.03) | 75.69 (6.23) | 74.14 (6.00) | 75.00 (5.56) | 0.048 | |
| EDUC (mean (SD)) | 15.78 (2.66) | 16.98 (2.51) | 15.78 (2.40) | 16.10 (2.53) | 0.002 | |
| SEX = 2 (%) | 33 (67.3) | 54 (61.4) | 137 (65.2) | 42 (61.8) | 0.852 | |
| site_id_factor (%) | <0.001 | |||||
| 4 | 0 ( 0.0) | 0 ( 0.0) | 64 (30.5) | 0 ( 0.0) | ||
| 9 | 0 ( 0.0) | 17 (19.3) | 0 ( 0.0) | 0 ( 0.0) | ||
| 16 | 10 (20.4) | 0 ( 0.0) | 69 (32.9) | 0 ( 0.0) | ||
| 18 | 15 (30.6) | 24 (27.3) | 0 ( 0.0) | 0 ( 0.0) | ||
| 19 | 0 ( 0.0) | 40 (45.5) | 0 ( 0.0) | 2 ( 2.9) | ||
| 21 | 24 (49.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | ||
| 30 | 0 ( 0.0) | 7 ( 8.0) | 0 ( 0.0) | 0 ( 0.0) | ||
| 37 | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 24 (35.3) | ||
| 42 | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 41 (60.3) | ||
| 43 | 0 ( 0.0) | 0 ( 0.0) | 10 ( 4.8) | 1 ( 1.5) | ||
| 67 | 0 ( 0.0) | 0 ( 0.0) | 67 (31.9) | 0 ( 0.0) | ||
| ptau181_scale (mean (SD)) | 0.25 (1.00) | 0.10 (0.83) | -0.14 (0.78) | 0.14 (0.85) | 0.004 | |
| Abeta42_scale (mean (SD)) | -0.04 (1.20) | -0.05 (0.98) | 0.10 (0.90) | -0.11 (0.98) | 0.333 | |
| trails_b (mean (SD)) | 95.73 (48.59) | 95.21 (52.85) | 101.75 (55.28) | 92.93 (55.03) | 0.594 | |
| CRAFTDVR (mean (SD)) | 19.06 (7.48) | 18.25 (7.26) | 17.52 (9.11) | 19.38 (6.31) | 0.332 | |
| UDSVERFC (mean (SD)) | 14.73 (3.55) | 16.08 (4.82) | 13.69 (4.38) | 15.40 (4.85) | <0.001 | |
| ANIMALS (mean (SD)) | 19.71 (4.08) | 19.60 (5.93) | 19.60 (5.34) | 20.91 (4.88) | 0.330 |
##
##
## Table: UDS3M+ predicated by language (English vs Spanish)
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|---------:|----------:|---------:|---------:|
## |(Intercept) | 0.4723000| 0.1751801| 2.6960826| 0.0097685|
## |Language (Spanish) | 0.3722333| 0.2261565| 1.6459102| 0.1065989|
## |site_id_factor21 | 0.0419500| 0.2085060| 0.2011932| 0.8414345|Heatmap
Provides pearson correlation between the UDS3M+ and various outcomes within the full sample. Trails A and B have NOT been reverse scored; negative correlations are expected.
Heatmap: Full sample
## [1] "Values in heatmap are: Correlation (no covariates). Spearman used for spearman.list, pearson for other variables"
Heatmap (CDR 0.5)
## [1] "Values in heatmap are: Correlation (no covariates). Spearman used for spearman.list, pearson for other variables"
Fmem by CDR sum of boxes
There is a limited range of CDR sbs, but there is still a nice, negative correlation with the UDS3M+: r= -.34 [-0.43 -0.27].
Ptau
Raw units:
Histogram of Ptau in raw units.
## vars n mean sd median trimmed mad min max range
## ptau181 raw units 1 459 31.07 15.74 28.41 28.96 11.15 7.65 146.99 139.34
## skew kurtosis se
## ptau181 raw units 3.03 15.85 0.73
Scaled units:
Histogram of Ptau in scaled units with windsorized values. Plot of Ptau X memory in scaled units.
Presents series of regression formulas followed by outputs. Fmem_bayes3 is the UDS3M+.
We found an interesting interaction where the association between UDS3M+ and Ptau differs by CDR global score. There is a more negative relationship within the CDR global .5 group as compared to the 0 group. This interaction (Ptau X CDR global) is significant: b=-.16, p=.03 while controlling for age, education, and sex.
## vars n mean sd median trimmed mad min
## ptau181 scaled and windsorized 1 459 -0.04 0.83 -0.17 -0.14 0.71 -1.49
## max range skew kurtosis se
## ptau181 scaled and windsorized 3 4.49 1.33 2.32 0.04## `stat_bin()` using `bins = 30`. Pick better value with `binwidth`.
##
##
## Table: UDS3M+ predicted by ptau 181 (scaled), controling for CDR global, age, sex, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:----------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 0.4658244| 0.4198902| 1.109396| 0.2678507|
## |ptau181_scale | -0.0926956| 0.0383116| -2.419518| 0.0159356|
## |CDR Global (0.5) | -0.5337764| 0.0667314| -7.998884| 0.0000000|
## |age | -0.0089070| 0.0051004| -1.746313| 0.0814374|
## |Sex (F) | 0.1567103| 0.0657203| 2.384505| 0.0175145|
## |EDUC | 0.0804660| 0.0116169| 6.926638| 0.0000000|##
##
## Table: UDS3M+ predicted by the interaction of ptau181 (scale) and CDR global score, controling for age, sex, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:--------------------------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 0.4344505| 0.4186217| 1.0378118| 0.2999150|
## |ptau181_scale | -0.0392107| 0.0460230| -0.8519802| 0.3946782|
## |CDR Global (0.5) | -0.5277854| 0.0665489| -7.9307885| 0.0000000|
## |age | -0.0085231| 0.0050851| -1.6760942| 0.0944143|
## |Sex (F) | 0.1559226| 0.0654803| 2.3812136| 0.0176707|
## |EDUC | 0.0810177| 0.0115773| 6.9979671| 0.0000000|
## |Ptau181 x CDR Global (0.5) interaction | -0.1596502| 0.0767483| -2.0801801| 0.0380743|## `geom_smooth()` using formula = 'y ~ x'## Warning: Removed 2 rows containing non-finite outside the scale range
## (`stat_smooth()`).## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
Imaging
Most analyses below control for age, education, and TIV.
Hippocampal Volume. Avg. left and right hippocamus; Z scored.
No significant association between hippocampal volume and UDS3M+ in full sample. Controlling for language slightly improves this finding (trending: b=.07, p=.06).
##
##
## Table: UDS3M+ predicted by avg hippocampal volume, controling for age, TIV, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 1.6150196| 0.5218772| 3.094635| 0.0020957|
## |Hippocampal Volume | 0.0848723| 0.0387867| 2.188181| 0.0291793|
## |age | -0.0103164| 0.0057194| -1.803765| 0.0719488|
## |TIV | -0.0010385| 0.0003253| -3.192862| 0.0015093|
## |EDUC | 0.0894459| 0.0129184| 6.923930| 0.0000000|##
##
## Table: UDS3M+ predicted by avg hippocampal volume, controling for TIV, education. [not age]
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 0.9710657| 0.3816282| 2.544533| 0.0112807|
## |Hippocampal Volume | 0.1064494| 0.0369897| 2.877813| 0.0041980|
## |TIV | -0.0011321| 0.0003219| -3.516603| 0.0004822|
## |EDUC | 0.0883955| 0.0129380| 6.832225| 0.0000000|##
##
## Table: UDS3M+ predicted by avg hippocampal volume, controling for age, TIV, education, language
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 2.4311524| 0.5175255| 4.697648| 0.0000035|
## |Hippocampal Volume | 0.1120497| 0.0378808| 2.957954| 0.0032638|
## |age | -0.0111352| 0.0054962| -2.025964| 0.0433714|
## |TIV | -0.0012929| 0.0003153| -4.100670| 0.0000491|
## |EDUC | 0.0649351| 0.0130100| 4.991187| 0.0000009|
## |Langauge (Spanish) | -0.7382098| 0.1181592| -6.247586| 0.0000000|Hippocampal Volume. Avg. left and right hippocamus; Z scored. In subsample of CDR 0.5.
No significant association between hippocampal volume and UDS3M+ in full sample.
##
##
## Table: UDS3M+ predicted by avg hippocampal volume, age, TIV, education, in CDR 0.5
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 0.7814603| 0.8302597| 0.9412240| 0.3483770|
## |Hippocampal Volume | 0.1056375| 0.0610564| 1.7301625| 0.0860305|
## |age | -0.0143885| 0.0090693| -1.5865059| 0.1151113|
## |TIV | -0.0004340| 0.0005730| -0.7574691| 0.4501720|
## |EDUC | 0.0919435| 0.0209998| 4.3783094| 0.0000247|##
##
## Table: UDS3M+ predicted by avg hippocampal volume, TIV, education, in CDR 0.5
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | -0.0401951| 0.6527625| -0.0615768| 0.9509959|
## |Hippocampal Volume | 0.1322055| 0.0590619| 2.2384244| 0.0269211|
## |cerebrum_all_tcv | -0.0006376| 0.0005618| -1.1350497| 0.2584755|
## |TIV | 0.0909363| 0.0211142| 4.3068825| 0.0000327|##
##
## Table: UDS3M+ predicted by avg hippocampal volume, TIV, age, langauge, education, in CDR 0.5
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 1.2624457| 0.8560521| 1.4747300| 0.1427795|
## |Hippocampal Volume | 0.1303092| 0.0616383| 2.1140960| 0.0364780|
## |age | -0.0141373| 0.0089676| -1.5764758| 0.1174237|
## |TIV | -0.0005636| 0.0005703| -0.9882523| 0.3249231|
## |EDUC | 0.0853940| 0.0210241| 4.0617234| 0.0000850|
## |Language (Spanish) | -0.2299759| 0.1161333| -1.9802745| 0.0498515|Hippocampal Volume. Avg. left and right hippocamus; Z scored. Elevated PTau subsample
Significant associations between UDS3M+ and Ptau within this high PTau group (n=46)
##
##
## Table: UDS3M+ predicted by avg hippocampal volume, age, TIV, education, in high PTau group
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 4.1220765| 1.8955001| 2.174664| 0.0356274|
## |Hippocampal Volume | 0.2983415| 0.0981627| 3.039255| 0.0041677|
## |age | -0.0227233| 0.0170306| -1.334263| 0.1896642|
## |TIV | -0.0024514| 0.0009173| -2.672372| 0.0108450|
## |EDUC | 0.0855577| 0.0372390| 2.297533| 0.0268986|##
##
## Table: UDS3M+ predicted by avg hippocampal volume, TIV, education, in high ptau group
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 2.2191685| 1.2603893| 1.760701| 0.0857469|
## |Hippocampal Volume | 0.3164684| 0.0981387| 3.224704| 0.0024770|
## |TIV | -0.0023620| 0.0009235| -2.557638| 0.0143332|
## |EDUC | 0.0879091| 0.0375495| 2.341150| 0.0241667|##
##
## Table: UDS3M+ predicted by avg hippocampal volume, TIV, age, langauge, education, in high ptau group
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 4.1197658| 1.9211801| 2.1443934| 0.0382907|
## |Hippocampal Volume | 0.2993053| 0.1045059| 2.8640042| 0.0067017|
## |age | -0.0226408| 0.0174671| -1.2961963| 0.2025261|
## |TIV | -0.0024518| 0.0009291| -2.6389136| 0.0118915|
## |EDUC | 0.0855891| 0.0377275| 2.2686133| 0.0289046|
## |Language (Spanish) | -0.0044202| 0.1478132| -0.0299038| 0.9762963|entorhinal and UDS3M+
##
##
## Table: UDS3M+ predicted by avg entorhinal volume, age, TIV, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:-----------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 1.1939928| 0.5315336| 2.246317| 0.0251768|
## |Entorhinal Volume | 0.1639308| 0.0717832| 2.283694| 0.0228631|
## |age | -0.0121739| 0.0055082| -2.210144| 0.0276068|
## |TIV | -0.0011302| 0.0003441| -3.284785| 0.0011018|
## |EDUC | 0.0898597| 0.0129207| 6.954691| 0.0000000|##
##
## Table: UDS3M+ predicted by avg entorhinal volume, TIV, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:-----------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 0.2863286| 0.3389213| 0.8448232| 0.3986656|
## |Entorhinal Volume | 0.1891840| 0.0711780| 2.6579006| 0.0081473|
## |TIV | -0.0011977| 0.0003442| -3.4797102| 0.0005517|
## |EDUC | 0.0883539| 0.0129592| 6.8178476| 0.0000000|##
##
## Table: UDS3M+ predicted by avg entorhinal volume, TIV, age, langauge, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 1.8051598| 0.5468366| 3.301096| 0.0010413|
## |Entorhinal Volume | 0.1988322| 0.0712588| 2.790284| 0.0054945|
## |age | -0.0126226| 0.0054249| -2.326771| 0.0204295|
## |TIV | -0.0012630| 0.0003405| -3.708957| 0.0002347|
## |EDUC | 0.0779671| 0.0130908| 5.955889| 0.0000000|
## |Language (Spanish) | -0.3470129| 0.0899613| -3.857359| 0.0001317|parahippocampal and UDS3M+
##
##
## Table: UDS3M+ predicted by avg parahippocampal volume, age, TIV, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:----------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 1.2745942| 0.5797757| 2.1984265| 0.0284363|
## |Parahippocampus Volume | 0.0740678| 0.0964185| 0.7681906| 0.4427842|
## |age | -0.0131461| 0.0056284| -2.3356881| 0.0199539|
## |TIV | -0.0007999| 0.0003356| -2.3839393| 0.0175496|
## |EDUC | 0.0881275| 0.0129642| 6.7977685| 0.0000000|##
##
## Table: UDS3M+ predicted by avg parahippocampal volume, TIV, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:----------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 0.2282084| 0.3698634| 0.6170072| 0.5375469|
## |Parahippocampus Volume | 0.1277199| 0.0941120| 1.3571053| 0.1754388|
## |TIV | -0.0009011| 0.0003344| -2.6944155| 0.0073192|
## |EDUC | 0.0863132| 0.0130058| 6.6365153| 0.0000000|##
##
## Table: UDS3M+ predicted by avg parahippocampal volume, TIV, age, langauge, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:----------------------|----------:|----------:|---------:|---------:|
## |(Intercept) | 1.8327112| 0.5932275| 3.089390| 0.0021325|
## |Parahippocampus Volume | 0.0977753| 0.0953957| 1.024945| 0.3059511|
## |age | -0.0136273| 0.0055568| -2.452369| 0.0145784|
## |TIV | -0.0008761| 0.0003319| -2.639937| 0.0085862|
## |EDUC | 0.0767733| 0.0131853| 5.822647| 0.0000000|
## |Language (Spanish) | -0.3215746| 0.0901293| -3.567927| 0.0003993|WMHs.Log transformed due to heavy skew.
No significant association in full sample.
##
##
## Table: UDS3M+ predicted by white matter hyperintensity volume
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:-----------|----------:|----------:|--------:|---------:|
## |(Intercept) | 1.0354639| 0.0361334| 28.65671| 0.0000000|
## |WMH Volume | -0.0244749| 0.0224057| -1.09235| 0.2752701|##
##
## Table: UDS3M+ predicted by white matter hyperintensity volume, age, TIV, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:-----------|----------:|----------:|----------:|---------:|
## |(Intercept) | 1.4183957| 0.5558869| 2.5515906| 0.0110604|
## |WMH Volume | -0.0061932| 0.0232347| -0.2665507| 0.7899400|
## |age | -0.0134880| 0.0059539| -2.2653975| 0.0239736|
## |TIV | -0.0006472| 0.0002779| -2.3286316| 0.0203307|
## |EDUC | 0.0879937| 0.0130198| 6.7584543| 0.0000000|##
##
## Table: UDS3M+ predicted by white matter hyperintensity volume, age, TIV, education, language
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 1.9923419| 0.5725869| 3.4795448| 0.0005525|
## |WMH Volume | -0.0116136| 0.0229919| -0.5051164| 0.6137306|
## |age | -0.0137674| 0.0058790| -2.3418047| 0.0196370|
## |TIV | -0.0006719| 0.0002745| -2.4476456| 0.0147700|
## |EDUC | 0.0767009| 0.0132497| 5.7888825| 0.0000000|
## |Language (Spanish) | -0.3179274| 0.0903940| -3.5171288| 0.0004817|WMHs.Log transformed due to heavy skew. Subsample with 0.5 CDR
No significant association in CDR 0.5 subsample.
## [1] "fmem_bayes3~wmh_log"##
## Call:
## lm(formula = fml, data = df.ggplot.0.5)
##
## Residuals:
## Min 1Q Median 3Q Max
## -1.89831 -0.43658 -0.06805 0.40408 2.04984
##
## Coefficients:
## Estimate Std. Error t value Pr(>|t|)
## (Intercept) 0.62384 0.06947 8.980 2.52e-15 ***
## wmh_log -0.04849 0.04080 -1.189 0.237
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## Residual standard error: 0.7312 on 131 degrees of freedom
## (2 observations deleted due to missingness)
## Multiple R-squared: 0.01067, Adjusted R-squared: 0.003116
## F-statistic: 1.413 on 1 and 131 DF, p-value: 0.2368##
##
## Table: UDS3M+ predicted by white matter hyperintensity volume, age, TIV, education
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:-----------|----------:|----------:|----------:|---------:|
## |(Intercept) | 0.2155831| 0.9199575| 0.2343403| 0.8150982|
## |WMH Volume | -0.0344937| 0.0439626| -0.7846152| 0.4341403|
## |age | -0.0155415| 0.0096407| -1.6120759| 0.1094278|
## |TIV | 0.0001765| 0.0005245| 0.3365237| 0.7370314|
## |EDUC | 0.0878024| 0.0212686| 4.1282658| 0.0000657|##
##
## Table: UDS3M+ predicted by white matter hyperintensity volume, age, TIV, education, language
##
## | | Estimate| Std. Error| t value| Pvalue|
## |:------------------|----------:|----------:|----------:|---------:|
## |(Intercept) | 0.5177137| 0.9328248| 0.5549957| 0.5798815|
## |WMH Volume | -0.0393491| 0.0437841| -0.8987074| 0.3705227|
## |age | -0.0157335| 0.0095798| -1.6423547| 0.1030100|
## |TIV | 0.0001802| 0.0005211| 0.3457231| 0.7301274|
## |EDUC | 0.0818629| 0.0214470| 3.8169944| 0.0002107|
## |Language (Spanish) | -0.1877811| 0.1156304| -1.6239774| 0.1068797|