Multicenter Test-Retest and Acquisition Protocol Reproducibility of Liver Iron Quantification - Subgroups by LIC

Table 1: Number of subjects by LIC group and site.

Consider groups of subjects with LIC in (0,1.8], (1.8,3.2], (3.2,7], (7,15], (15,Inf].

Summary by LIC groups

Characteristic	UW, N = 591	UTSW, N = 481	JHU, N = 521	Stanford, N = 461	Overall, N = 2051
LIC group
(0,1.8]	13 (23%)	26 (54%)	12 (24%)	14 (33%)	65 (33%)
(1.8,3.2]	12 (21%)	7 (15%)	8 (16%)	9 (21%)	36 (18%)
(3.2,7]	17 (30%)	5 (10%)	10 (20%)	5 (12%)	37 (19%)
(7,15]	12 (21%)	4 (8.3%)	8 (16%)	13 (30%)	37 (19%)
(15,Inf]	3 (5.3%)	6 (13%)	12 (24%)	2 (4.7%)	23 (12%)
Unknown	2	0	2	3	7
1 n (%)

LIC (0,1.8]

This section looks into the repeatability and reproducibility for subjects with LIC \(\in\) (0,1.8].

Repeatability analysis

The number of pairs for test-retest repeatability analysis by protocol, field strength, and lobe is listed below.

Overall

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol and field strength across all segments/lobes below.

Test-retest repeatability analysis by protocol and field strength across all segments/lobes.

Protocol	Field	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	0.5	1% (-28.5%, 30.6%)	13.5	0.963 (0.954, 0.97)	< 0.001
P01	3.0T	0.5	0.6% (-18.7%, 20%)	17.0	0.987 (0.983, 0.989)	< 0.001
P02	1.5T	0.0	-0.2% (-24.3%, 24%)	11.8	0.968 (0.96, 0.974)	< 0.001
P02	3.0T	-1.1	-0.8% (-22.7%, 21%)	16.8	0.985 (0.981, 0.988)	< 0.001
P04	1.5T	-0.1	-0.1% (-25.7%, 25.5%)	12.3	0.972 (0.965, 0.978)	< 0.001
P04	3.0T	0.4	0.8% (-37.8%, 39.5%)	26.8	0.973 (0.966, 0.979)	< 0.001
P08	1.5T	-0.3	-0.1% (-30.4%, 30.2%)	14.6	0.954 (0.943, 0.964)	< 0.001
P08	3.0T	0.1	0.2% (-34.1%, 34.5%)	29.2	0.963 (0.953, 0.971)	< 0.001

By lobe

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol, field strength, and lobe below.

Test-retest repeatability analysis by protocol, field strength, and lobe.

Protocol	Field	Lobe	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	Left	0.5	0.8% (-31.7%, 33.4%)	15.6	0.964 (0.952, 0.973)	< 0.001
P01	1.5T	Right	0.6	1.3% (-24.1%, 26.7%)	10.3	0.959 (0.944, 0.971)	< 0.001
P01	3.0T	Left	0.6	0.9% (-21%, 22.8%)	19.4	0.987 (0.982, 0.99)	< 0.001
P01	3.0T	Right	0.4	0.3% (-15.3%, 16%)	13.3	0.986 (0.981, 0.99)	< 0.001
P02	1.5T	Left	-0.1	-0.4% (-27.4%, 26.6%)	13.5	0.969 (0.958, 0.977)	< 0.001
P02	1.5T	Right	0.1	0.1% (-19.9%, 20.2%)	9.2	0.966 (0.952, 0.975)	< 0.001
P02	3.0T	Left	-1.1	-1.1% (-27.6%, 25.3%)	19.9	0.984 (0.978, 0.988)	< 0.001
P02	3.0T	Right	-1.1	-0.4% (-14.7%, 13.9%)	11.9	0.988 (0.983, 0.991)	< 0.001
P04	1.5T	Left	-0.2	-0.6% (-30.5%, 29.3%)	13.8	0.973 (0.964, 0.98)	< 0.001
P04	1.5T	Right	0.1	0.5% (-18.4%, 19.4%)	10.2	0.969 (0.957, 0.978)	< 0.001
P04	3.0T	Left	1.2	1.3% (-35.2%, 37.8%)	28.6	0.977 (0.968, 0.983)	< 0.001
P04	3.0T	Right	-0.5	0.2% (-41.1%, 41.6%)	24.4	0.964 (0.948, 0.975)	< 0.001
P08	1.5T	Left	-0.5	-0.5% (-30.4%, 29.3%)	16.1	0.957 (0.941, 0.968)	< 0.001
P08	1.5T	Right	0.1	0.4% (-30.5%, 31.4%)	12.5	0.949 (0.929, 0.964)	< 0.001
P08	3.0T	Left	0.0	0.3% (-40%, 40.6%)	34.1	0.96 (0.946, 0.971)	< 0.001
P08	3.0T	Right	0.3	0% (-25%, 25.1%)	21.6	0.97 (0.957, 0.979)	< 0.001

Reproducibility analysis

Overall

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized across all segments/lobes below.

Between-protocol reproducibility analysis across all segments/lobes for smaller values.

Field	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	P01	P02	3.3	6.7% (-23.6%, 37%)	14.2	0.926 (0.914, 0.937)
		P03	2.5	6.1% (-26.5%, 38.8%)	14.4	0.84 (0.801, 0.872)
		P04	2.6	6.3% (-24.9%, 37.5%)	13.7	0.941 (0.931, 0.95)
		P05	4.7	11.3% (-17.5%, 40.1%)	13.5	0.812 (0.769, 0.848)
		P06	3.2	8.1% (-25.1%, 41.3%)	15.4	0.81 (0.766, 0.847)
		P07	5.3	12.2% (-17.3%, 41.8%)	13.2	0.795 (0.75, 0.832)
		P08	4.3	9.6% (-23.7%, 42.9%)	15.4	0.908 (0.893, 0.921)
		P09	3.5	8.3% (-26.8%, 43.3%)	14.8	0.815 (0.771, 0.852)
		P10	4.6	10.8% (-27.4%, 49%)	16.3	0.764 (0.709, 0.809)
	P02	P03	-0.8	-1.4% (-31.9%, 29.2%)	13.0	0.874 (0.842, 0.899)
		P04	-0.6	-0.4% (-27.6%, 26.7%)	13.4	0.947 (0.938, 0.954)
		P05	1.2	3.3% (-26.6%, 33.3%)	13.3	0.86 (0.825, 0.889)
		P06	-0.2	0.3% (-32.8%, 33.3%)	14.3	0.851 (0.815, 0.881)
		P07	1.8	4.4% (-24.7%, 33.5%)	12.2	0.869 (0.836, 0.895)
		P08	1.0	2.9% (-25.2%, 30.9%)	13.8	0.936 (0.925, 0.946)
		P09	0.2	1% (-35.1%, 37%)	15.7	0.813 (0.767, 0.851)
		P10	1.3	3.6% (-31.5%, 38.8%)	14.5	0.835 (0.792, 0.869)
	P03	P04	0.8	1.7% (-25.2%, 28.7%)	12.6	0.892 (0.864, 0.914)
		P05	1.9	4.2% (-19%, 27.3%)	10.7	0.912 (0.888, 0.93)
		P06	0.4	0.8% (-25.3%, 26.9%)	11.3	0.915 (0.892, 0.933)
		P07	2.5	5.5% (-22.5%, 33.5%)	12.3	0.874 (0.842, 0.899)
		P08	2.2	5.3% (-23.2%, 33.8%)	12.4	0.88 (0.85, 0.904)
		P09	1.0	2.4% (-30.6%, 35.3%)	15.2	0.84 (0.799, 0.874)
		P10	1.9	4% (-27.3%, 35.2%)	13.4	0.866 (0.832, 0.894)
	P04	P05	1.3	3% (-21.8%, 27.8%)	12.2	0.892 (0.864, 0.915)
		P06	-0.1	0.1% (-29.9%, 30.1%)	13.9	0.87 (0.837, 0.897)
		P07	1.9	4.3% (-21.9%, 30.4%)	11.4	0.892 (0.865, 0.914)
		P08	1.7	3.2% (-21.2%, 27.6%)	13.4	0.945 (0.936, 0.953)
		P09	0.3	0.8% (-32.1%, 33.7%)	15.6	0.829 (0.786, 0.864)
		P10	1.3	3.3% (-26.5%, 33.1%)	13.3	0.871 (0.837, 0.898)
	P05	P06	-1.5	-3.4% (-28.2%, 21.5%)	10.8	0.914 (0.891, 0.932)
		P07	0.6	1.3% (-24.8%, 27.4%)	11.1	0.904 (0.879, 0.924)
		P08	0.2	0.5% (-26.4%, 27.3%)	11.5	0.904 (0.878, 0.924)
		P09	-0.9	-2.2% (-36%, 31.5%)	15.6	0.828 (0.783, 0.864)
		P10	-0.1	-0.9% (-29.2%, 27.5%)	13.0	0.876 (0.842, 0.903)
	P06	P07	2.0	4.1% (-27.9%, 36.2%)	13.6	0.855 (0.82, 0.883)
		P08	1.7	3.8% (-22.9%, 30.5%)	12.0	0.893 (0.866, 0.916)
		P09	0.5	0.6% (-39.1%, 40.3%)	17.9	0.784 (0.731, 0.828)
		P10	1.5	2.8% (-35%, 40.5%)	16.7	0.804 (0.755, 0.844)
	P07	P08	-0.5	-0.8% (-29%, 27.4%)	12.4	0.882 (0.851, 0.906)
		P09	-1.6	-3.5% (-34.6%, 27.5%)	14.1	0.841 (0.801, 0.874)
		P10	-0.4	-1% (-33.3%, 31.3%)	12.9	0.87 (0.835, 0.898)
	P08	P09	-1.0	-2.6% (-35%, 29.7%)	13.9	0.86 (0.824, 0.89)
		P10	-0.3	-1.1% (-29.3%, 27.1%)	12.2	0.89 (0.86, 0.913)
	P09	P10	1.2	2.8% (-32.6%, 38.2%)	14.0	0.852 (0.814, 0.883)
3.0T	P01	P02	4.7	5.8% (-19.1%, 30.7%)	18.1	0.971 (0.967, 0.976)
		P03	1.3	3.5% (-37.9%, 45%)	24.3	0.901 (0.874, 0.922)
		P04	2.2	4.8% (-32.7%, 42.2%)	23.6	0.96 (0.953, 0.966)
		P05	3.7	7.7% (-30.4%, 45.8%)	26.5	0.886 (0.856, 0.911)
		P06	3.2	6.2% (-31.4%, 43.7%)	24.9	0.896 (0.868, 0.919)
		P07	5.1	8.7% (-29%, 46.4%)	25.9	0.88 (0.846, 0.906)
		P08	5.5	9.1% (-27.4%, 45.5%)	26.6	0.951 (0.942, 0.959)
		P09	-6.3	0.2% (-64.1%, 64.5%)	96.5	0.393 (0.297, 0.482)
		P10	4.5	9.6% (-55%, 74.3%)	33.3	0.827 (0.777, 0.867)
	P02	P03	-1.8	-0.8% (-37.9%, 36.4%)	23.0	0.906 (0.881, 0.926)
		P04	-2.4	-0.9% (-37.2%, 35.3%)	24.1	0.955 (0.947, 0.961)
		P05	0.5	3.1% (-30.8%, 37.1%)	22.8	0.917 (0.896, 0.934)
		P06	-0.1	1.7% (-29.4%, 32.8%)	21.7	0.922 (0.901, 0.938)
		P07	1.9	4.3% (-25.3%, 33.9%)	20.3	0.929 (0.909, 0.945)
		P08	0.7	3.3% (-32.4%, 39.1%)	25.4	0.958 (0.951, 0.964)
		P09	-9.4	-3.9% (-64.1%, 56.3%)	93.9	0.406 (0.316, 0.489)
		P10	1.1	4.8% (-57.2%, 66.8%)	30.7	0.854 (0.812, 0.888)
	P03	P04	1.1	1.8% (-39.5%, 43.1%)	19.5	0.939 (0.922, 0.952)
		P05	2.2	3.8% (-36.3%, 43.8%)	27.2	0.891 (0.86, 0.915)
		P06	1.7	2.3% (-38.9%, 43.4%)	24.6	0.908 (0.882, 0.928)
		P07	3.6	4.8% (-36.5%, 46.1%)	28.4	0.872 (0.836, 0.9)
		P08	4.2	6.6% (-33.4%, 46.7%)	29.5	0.862 (0.825, 0.892)
		P09	-8.1	-4.3% (-69.4%, 60.8%)	93.9	0.433 (0.338, 0.519)
		P10	2.8	5.3% (-65.3%, 75.8%)	36.5	0.809 (0.754, 0.853)
	P04	P05	1.1	2.1% (-40.6%, 44.7%)	28.0	0.885 (0.854, 0.91)
		P06	0.6	0.7% (-35.8%, 37.1%)	20.9	0.934 (0.915, 0.949)
		P07	2.5	3.2% (-37.5%, 43.9%)	27.5	0.882 (0.849, 0.909)
		P08	3.2	4.3% (-35.6%, 44.1%)	29.0	0.942 (0.931, 0.951)
		P09	-9.5	-6.2% (-71.1%, 58.7%)	93.2	0.435 (0.342, 0.519)
		P10	1.1	2.6% (-68.3%, 73.5%)	35.6	0.82 (0.767, 0.862)
	P05	P06	-0.5	-1.5% (-37.5%, 34.6%)	26.7	0.899 (0.871, 0.921)
		P07	1.4	1.1% (-36.6%, 38.7%)	23.8	0.918 (0.895, 0.937)
		P08	2.0	3% (-35.2%, 41.3%)	23.2	0.924 (0.903, 0.942)
		P09	-10.1	-7.2% (-72.7%, 58.3%)	97.4	0.432 (0.33, 0.523)
		P10	1.0	2.1% (-67.2%, 71.5%)	36.6	0.83 (0.778, 0.87)
	P06	P07	1.8	2.3% (-30.7%, 35.4%)	24.0	0.913 (0.888, 0.933)
		P08	2.4	4.3% (-33.6%, 42.3%)	29.8	0.871 (0.835, 0.9)
		P09	-10.2	-6.8% (-68.9%, 55.2%)	95.1	0.447 (0.35, 0.534)
		P10	0.9	2.5% (-65.7%, 70.6%)	35.3	0.836 (0.786, 0.875)
	P07	P08	0.6	2% (-33.2%, 37.2%)	22.4	0.925 (0.904, 0.942)
		P09	-11.8	-8.8% (-69.6%, 52%)	94.8	0.437 (0.343, 0.523)
		P10	-0.5	0.9% (-64.7%, 66.6%)	32.3	0.857 (0.813, 0.891)
	P08	P09	-12.8	-11.9% (-74.1%, 50.3%)	94.9	0.419 (0.322, 0.507)
		P10	-1.6	-1.4% (-69.9%, 67.1%)	37.5	0.805 (0.748, 0.85)
	P09	P10	11.1	7.3% (-54.3%, 69%)	94.6	0.445 (0.35, 0.53)

By lobe

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized by lobe below.

Between-protocol reproducibility analysis of R2* by lobe for smaller values.

Field	Lobe	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	Left	P01	P02	3.5	7% (-23.8%, 37.9%)	15.9	0.927 (0.911, 0.941)
			P03	3.7	8.8% (-23.5%, 41%)	14.4	0.795 (0.73, 0.846)
			P04	3.1	7.2% (-25.9%, 40.2%)	14.4	0.946 (0.933, 0.956)
			P05	5.6	13.4% (-15.5%, 42.3%)	12.9	0.781 (0.715, 0.833)
			P06	4.6	11% (-21.2%, 43.2%)	14.1	0.778 (0.71, 0.832)
			P07	5.9	14% (-14.9%, 42.8%)	12.5	0.766 (0.7, 0.819)
			P08	4.9	10.3% (-25.9%, 46.6%)	17.0	0.907 (0.887, 0.924)
			P09	2.8	7.6% (-28.5%, 43.7%)	15.1	0.819 (0.759, 0.865)
			P10	4.5	11% (-26.7%, 48.8%)	15.9	0.754 (0.677, 0.816)
		P02	P03	-0.2	0.2% (-30.4%, 30.7%)	13.4	0.837 (0.782, 0.879)
			P04	-0.4	0.1% (-30%, 30.2%)	15.5	0.942 (0.93, 0.953)
			P05	1.6	4.6% (-23.6%, 32.9%)	12.3	0.853 (0.802, 0.891)
			P06	0.5	2.1% (-27.8%, 31.9%)	12.8	0.846 (0.794, 0.885)
			P07	1.9	5.1% (-24.7%, 34.9%)	12.0	0.843 (0.79, 0.884)
			P08	1.4	3.4% (-27.5%, 34.3%)	15.4	0.934 (0.918, 0.947)
			P09	-1.2	-1.3% (-39.9%, 37.4%)	16.7	0.775 (0.706, 0.829)
			P10	0.5	2.3% (-30.9%, 35.4%)	14.3	0.82 (0.758, 0.867)
		P03	P04	0.4	1% (-28%, 30.1%)	12.3	0.878 (0.835, 0.911)
			P05	1.7	4.1% (-23.1%, 31.2%)	12.3	0.869 (0.822, 0.904)
			P06	0.6	1.4% (-28.2%, 31%)	12.8	0.867 (0.819, 0.903)
			P07	2.1	4.9% (-27.6%, 37.3%)	13.2	0.839 (0.784, 0.882)
			P08	1.7	4.3% (-27.7%, 36.4%)	13.9	0.835 (0.778, 0.878)
			P09	-0.9	-1.1% (-37.6%, 35.3%)	16.0	0.821 (0.759, 0.868)
			P10	0.7	1.9% (-29.4%, 33.2%)	12.9	0.869 (0.82, 0.906)
		P04	P05	1.4	3.2% (-23.3%, 29.7%)	11.1	0.895 (0.856, 0.923)
			P06	0.4	1% (-26.6%, 28.6%)	11.7	0.887 (0.846, 0.917)
			P07	1.7	4% (-27.3%, 35.4%)	12.6	0.851 (0.8, 0.89)
			P08	1.8	3.2% (-24.4%, 30.7%)	14.7	0.945 (0.934, 0.955)
			P09	-1.3	-2.3% (-38.6%, 34.1%)	15.6	0.822 (0.762, 0.868)
			P10	0.3	0.9% (-28.5%, 30.4%)	12.3	0.881 (0.837, 0.914)
		P05	P06	-1.1	-2.7% (-30.7%, 25.4%)	11.8	0.883 (0.841, 0.915)
			P07	0.4	0.8% (-28.7%, 30.3%)	11.6	0.884 (0.841, 0.915)
			P08	-0.1	-0.1% (-29.7%, 29.5%)	12.3	0.876 (0.831, 0.91)
			P09	-2.7	-5.6% (-43.7%, 32.5%)	16.9	0.786 (0.714, 0.842)
			P10	-1.0	-2.5% (-31.9%, 26.9%)	13.1	0.863 (0.811, 0.902)
		P06	P07	1.3	3% (-31.2%, 37.2%)	13.7	0.831 (0.774, 0.875)
			P08	1.0	2.6% (-26.5%, 31.6%)	12.2	0.875 (0.83, 0.909)
			P09	-1.8	-3.5% (-42.5%, 35.5%)	16.4	0.804 (0.738, 0.855)
			P10	-0.1	-0.2% (-34.2%, 33.9%)	14.4	0.839 (0.78, 0.884)
		P07	P08	-0.5	-0.9% (-33%, 31.1%)	12.7	0.861 (0.811, 0.898)
			P09	-3.1	-6.5% (-39.5%, 26.4%)	14.5	0.818 (0.76, 0.864)
			P10	-1.2	-2.7% (-36%, 30.6%)	13.2	0.85 (0.795, 0.891)
		P08	P09	-2.4	-5.2% (-41.7%, 31.3%)	15.1	0.829 (0.771, 0.873)
			P10	-0.9	-2.4% (-32.9%, 28.2%)	12.2	0.88 (0.835, 0.914)
		P09	P10	1.9	3.7% (-35.1%, 42.5%)	15.7	0.825 (0.764, 0.871)
	Right	P01	P02	3.0	6.2% (-23.4%, 35.9%)	11.7	0.923 (0.903, 0.939)
			P03	1.0	2.8% (-29.3%, 34.9%)	13.8	0.884 (0.837, 0.917)
			P04	2.1	5.2% (-23.4%, 33.8%)	12.6	0.93 (0.912, 0.944)
			P05	3.6	8.7% (-19.2%, 36.6%)	13.9	0.846 (0.786, 0.89)
			P06	1.5	4.6% (-28.7%, 37.8%)	16.4	0.84 (0.779, 0.886)
			P07	4.4	10% (-19.9%, 39.9%)	13.9	0.825 (0.761, 0.873)
			P08	3.7	8.7% (-20.6%, 37.9%)	12.9	0.907 (0.884, 0.926)
			P09	4.3	9.1% (-24.6%, 42.8%)	14.3	0.811 (0.745, 0.861)
			P10	4.7	10.6% (-28.4%, 49.5%)	16.8	0.773 (0.691, 0.835)
		P02	P03	-1.6	-3.3% (-33.6%, 27%)	12.6	0.902 (0.863, 0.931)
			P04	-0.9	-1.1% (-24%, 21.8%)	10.0	0.956 (0.946, 0.965)
			P05	0.8	1.8% (-30.1%, 33.7%)	14.6	0.866 (0.812, 0.906)
			P06	-1.2	-2% (-38.3%, 34.2%)	15.8	0.854 (0.798, 0.896)
			P07	1.7	3.5% (-24.8%, 31.8%)	12.4	0.89 (0.846, 0.922)
			P08	0.7	2.2% (-21.7%, 26%)	11.5	0.941 (0.925, 0.953)
			P09	2.0	3.8% (-28.1%, 35.7%)	13.5	0.859 (0.806, 0.898)
			P10	2.4	5.3% (-32%, 42.7%)	14.5	0.849 (0.79, 0.893)
		P03	P04	1.3	2.6% (-21.5%, 26.8%)	12.9	0.903 (0.863, 0.932)
			P05	2.0	4.3% (-12.6%, 21.1%)	8.4	0.949 (0.928, 0.964)
			P06	0.1	0% (-20.9%, 21%)	9.1	0.955 (0.935, 0.969)
			P07	3.0	6.2% (-15%, 27.4%)	11.2	0.904 (0.866, 0.931)
			P08	2.9	6.5% (-16.8%, 29.8%)	10.2	0.921 (0.889, 0.943)
			P09	3.4	6.8% (-18.9%, 32.4%)	12.8	0.865 (0.819, 0.9)
			P10	3.2	6.6% (-24%, 37.2%)	13.6	0.864 (0.813, 0.902)
		P04	P05	1.1	2.7% (-19.9%, 25.3%)	13.5	0.889 (0.843, 0.922)
			P06	-0.8	-1% (-33.7%, 31.6%)	16.2	0.855 (0.798, 0.897)
			P07	2.1	4.5% (-13.2%, 22.2%)	9.7	0.929 (0.901, 0.949)
			P08	1.6	3.2% (-16.6%, 23.1%)	11.6	0.944 (0.929, 0.955)
			P09	2.3	4.6% (-21.7%, 30.9%)	14.7	0.839 (0.783, 0.882)
			P10	2.7	6.2% (-23.2%, 35.6%)	14.1	0.861 (0.808, 0.9)
		P05	P06	-2.0	-4.2% (-24.5%, 16%)	9.3	0.941 (0.916, 0.958)
			P07	1.0	1.9% (-19.3%, 23.2%)	10.6	0.924 (0.892, 0.947)
			P08	0.5	1.2% (-21.7%, 24.1%)	10.4	0.93 (0.9, 0.951)
			P09	1.3	2% (-23.1%, 27.1%)	12.5	0.884 (0.839, 0.917)
			P10	1.0	1.2% (-25.4%, 27.7%)	12.7	0.889 (0.844, 0.922)
		P06	P07	2.9	5.5% (-23.6%, 34.6%)	13.5	0.874 (0.827, 0.908)
			P08	2.5	5.4% (-17.8%, 28.6%)	11.5	0.909 (0.873, 0.936)
			P09	3.2	5.7% (-32.8%, 44.2%)	18.3	0.766 (0.688, 0.826)
			P10	3.4	6.4% (-34.5%, 47.4%)	18.7	0.772 (0.691, 0.834)
		P07	P08	-0.5	-0.7% (-23.2%, 21.8%)	12.1	0.901 (0.86, 0.931)
			P09	0.3	0.2% (-26.7%, 27.1%)	12.7	0.874 (0.823, 0.91)
			P10	0.6	1.2% (-29.4%, 31.8%)	12.2	0.892 (0.846, 0.925)
		P08	P09	0.7	0.6% (-24.4%, 25.6%)	11.5	0.903 (0.865, 0.93)
			P10	0.6	0.5% (-24.2%, 25.1%)	12.2	0.9 (0.858, 0.929)
		P09	P10	0.4	1.7% (-28.9%, 32.4%)	11.4	0.894 (0.849, 0.926)
3.0T	Left	P01	P02	5.3	6.5% (-22.4%, 35.4%)	20.8	0.97 (0.963, 0.976)
			P03	1.8	5.1% (-45.1%, 55.3%)	28.3	0.861 (0.81, 0.899)
			P04	3.2	5.9% (-31.3%, 43%)	23.9	0.963 (0.954, 0.971)
			P05	3.8	7.3% (-34.6%, 49.2%)	27.1	0.863 (0.811, 0.901)
			P06	4.2	7.5% (-34.7%, 49.7%)	27.1	0.856 (0.801, 0.896)
			P07	5.9	9.8% (-32.8%, 52.3%)	28.9	0.831 (0.767, 0.878)
			P08	6.5	10.1% (-32.1%, 52.3%)	27.0	0.956 (0.945, 0.965)
			P09	-7.9	-2% (-70.3%, 66.4%)	95.6	0.358 (0.223, 0.479)
			P10	3.4	7.4% (-55.1%, 70%)	34.9	0.795 (0.713, 0.855)
		P02	P03	-1.5	0.3% (-44.6%, 45.2%)	24.5	0.89 (0.852, 0.919)
			P04	-1.8	-0.4% (-35.4%, 34.7%)	22.8	0.965 (0.957, 0.972)
			P05	0.1	2.1% (-35.1%, 39.3%)	22.9	0.903 (0.866, 0.93)
			P06	0.6	2.5% (-32.3%, 37.2%)	20.7	0.917 (0.885, 0.941)
			P07	2.3	4.7% (-29.1%, 38.6%)	22.3	0.901 (0.862, 0.93)
			P08	1.2	3.7% (-38.4%, 45.9%)	26.1	0.963 (0.954, 0.97)
			P09	-11.2	-6.4% (-68.7%, 56%)	91.8	0.384 (0.263, 0.493)
			P10	-0.5	1.7% (-55.3%, 58.7%)	29.8	0.847 (0.785, 0.893)
		P03	P04	1.2	1% (-41.7%, 43.6%)	21.6	0.924 (0.894, 0.945)
			P05	1.7	1.6% (-43.1%, 46.4%)	22.6	0.918 (0.886, 0.942)
			P06	2.1	1.9% (-46.6%, 50.5%)	25.2	0.894 (0.853, 0.923)
			P07	3.8	4.2% (-43.5%, 52%)	28.0	0.866 (0.816, 0.904)
			P08	4.3	6% (-39.5%, 51.6%)	24.5	0.894 (0.853, 0.924)
			P09	-10.0	-8.2% (-76.1%, 59.7%)	88.4	0.468 (0.341, 0.578)
			P10	1.3	1.5% (-67.7%, 70.7%)	35.7	0.81 (0.733, 0.867)
		P04	P05	0.5	0.8% (-36.1%, 37.7%)	22.1	0.919 (0.886, 0.942)
			P06	0.9	1.1% (-28.9%, 31.2%)	18.4	0.941 (0.917, 0.958)
			P07	2.6	3.4% (-32.2%, 39%)	23.9	0.899 (0.859, 0.928)
			P08	3.4	4.4% (-35.6%, 44.3%)	26.2	0.956 (0.945, 0.965)
			P09	-11.7	-9.2% (-68.6%, 50.2%)	88.7	0.443 (0.32, 0.552)
			P10	-0.7	-0.6% (-64.2%, 63.1%)	33.7	0.822 (0.749, 0.876)
		P05	P06	0.4	0.4% (-38%, 38.8%)	22.3	0.914 (0.88, 0.939)
			P07	2.0	2.4% (-38.7%, 43.6%)	24.6	0.894 (0.852, 0.925)
			P08	2.6	4.6% (-36.2%, 45.4%)	21.7	0.919 (0.886, 0.943)
			P09	-12.0	-9.5% (-76.1%, 57.2%)	93.9	0.409 (0.277, 0.526)
			P10	-0.5	-0.2% (-65%, 64.6%)	35.2	0.814 (0.735, 0.871)
		P06	P07	1.6	2.1% (-35.1%, 39.3%)	23.0	0.905 (0.867, 0.933)
			P08	2.2	4.3% (-37.1%, 45.6%)	22.4	0.912 (0.876, 0.938)
			P09	-12.6	-10.3% (-72.5%, 51.9%)	90.5	0.439 (0.315, 0.548)
			P10	-1.3	-1.4% (-68.5%, 65.8%)	36.3	0.795 (0.71, 0.857)
		P07	P08	0.5	2.2% (-36.4%, 40.8%)	21.4	0.92 (0.888, 0.944)
			P09	-14.2	-12.2% (-76.1%, 51.7%)	93.8	0.393 (0.265, 0.507)
			P10	-2.6	-2.8% (-65.2%, 59.6%)	32.5	0.829 (0.757, 0.881)
		P08	P09	-15.3	-15.7% (-79.4%, 47.9%)	92.0	0.391 (0.264, 0.505)
			P10	-3.5	-5.2% (-71.3%, 60.9%)	34.9	0.797 (0.715, 0.857)
		P09	P10	11.5	7.6% (-55.4%, 70.7%)	90.9	0.44 (0.314, 0.552)
	Right	P01	P02	4.1	4.9% (-13.9%, 23.7%)	13.9	0.974 (0.968, 0.98)
			P03	0.7	1.6% (-24.9%, 28.1%)	18.2	0.947 (0.924, 0.964)
			P04	1.0	3.4% (-34.4%, 41.1%)	23.2	0.954 (0.942, 0.964)
			P05	3.6	8.2% (-24.7%, 41%)	25.8	0.908 (0.871, 0.935)
			P06	1.9	4.4% (-26.3%, 35.2%)	21.8	0.934 (0.906, 0.954)
			P07	4.1	7.4% (-23.3%, 38.1%)	21.5	0.928 (0.895, 0.951)
			P08	4.1	7.7% (-19.8%, 35.2%)	25.9	0.94 (0.923, 0.953)
			P09	-4.3	3% (-55.8%, 61.8%)	98.1	0.432 (0.287, 0.557)
			P10	5.9	12.4% (-54.8%, 79.6%)	31.2	0.859 (0.793, 0.905)
		P02	P03	-2.1	-2.1% (-26.2%, 22%)	21.0	0.924 (0.891, 0.948)
			P04	-3.1	-1.6% (-39.4%, 36.2%)	25.7	0.937 (0.921, 0.95)
			P05	0.8	4.5% (-24.9%, 33.9%)	22.8	0.93 (0.905, 0.949)
			P06	-0.9	0.7% (-25.2%, 26.7%)	22.9	0.926 (0.896, 0.947)
			P07	1.3	3.7% (-19.6%, 27%)	17.4	0.956 (0.936, 0.969)
			P08	0.1	2.9% (-22.8%, 28.5%)	24.5	0.948 (0.934, 0.958)
			P09	-7.3	-0.7% (-57.9%, 56.5%)	97.0	0.43 (0.291, 0.551)
			P10	3.0	8.6% (-58.8%, 75.9%)	31.6	0.862 (0.797, 0.907)
		P03	P04	1.0	2.9% (-36.8%, 42.6%)	16.7	0.957 (0.937, 0.97)
			P05	2.9	6.5% (-26.2%, 39.2%)	32.2	0.862 (0.806, 0.903)
			P06	1.1	2.7% (-27%, 32.4%)	23.8	0.923 (0.89, 0.946)
			P07	3.2	5.6% (-26%, 37.2%)	29.1	0.878 (0.824, 0.916)
			P08	4.0	7.4% (-24.7%, 39.5%)	34.9	0.828 (0.757, 0.88)
			P09	-5.7	0.6% (-60%, 61.1%)	100.8	0.394 (0.245, 0.524)
			P10	4.6	10% (-61.5%, 81.5%)	37.3	0.808 (0.721, 0.87)
		P04	P05	1.9	3.7% (-45.2%, 52.6%)	34.0	0.854 (0.793, 0.898)
			P06	0.2	0% (-43.3%, 43.4%)	23.6	0.927 (0.895, 0.95)
			P07	2.3	3% (-43.5%, 49.5%)	31.5	0.866 (0.806, 0.908)
			P08	3.1	4.1% (-35.6%, 43.8%)	32.2	0.919 (0.895, 0.937)
			P09	-6.7	-2.5% (-73.5%, 68.5%)	98.9	0.426 (0.278, 0.554)
			P10	3.4	6.5% (-72.2%, 85.3%)	37.6	0.818 (0.733, 0.878)
		P05	P06	-1.7	-3.8% (-36.3%, 28.8%)	31.2	0.887 (0.836, 0.922)
			P07	0.6	-0.7% (-33.4%, 32%)	22.8	0.939 (0.911, 0.958)
			P08	1.3	1.1% (-33.4%, 35.7%)	25.0	0.929 (0.896, 0.952)
			P09	-7.7	-4.3% (-68.3%, 59.7%)	102.0	0.455 (0.293, 0.592)
			P10	2.9	5.1% (-69.6%, 79.8%)	38.3	0.844 (0.769, 0.896)
		P06	P07	2.0	2.7% (-24.5%, 29.8%)	25.3	0.92 (0.884, 0.946)
			P08	2.7	4.4% (-29%, 37.8%)	37.1	0.836 (0.764, 0.887)
			P09	-7.2	-2.5% (-63.6%, 58.6%)	100.9	0.456 (0.298, 0.589)
			P10	3.5	7.2% (-61.4%, 75.9%)	33.4	0.873 (0.809, 0.916)
		P07	P08	0.7	1.8% (-28.9%, 32.4%)	23.7	0.93 (0.897, 0.953)
			P09	-8.8	-4.6% (-60.6%, 51.5%)	96.4	0.485 (0.341, 0.607)
			P10	2.1	5.7% (-63.1%, 74.4%)	31.4	0.883 (0.824, 0.923)
		P08	P09	-9.7	-7.1% (-66.4%, 52.2%)	98.5	0.45 (0.297, 0.58)
			P10	0.9	3.4% (-67.2%, 73.9%)	40.1	0.813 (0.726, 0.875)
		P09	P10	10.5	7% (-53.4%, 67.3%)	99.7	0.447 (0.297, 0.576)

LIC (1.8,3.2]

This section looks into the repeatability and reproducibility for subjects with LIC \(\in\) (1.8,3.2].

Repeatability analysis

The number of pairs for test-retest repeatability analysis by protocol, field strength, and lobe is listed below.

Overall

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol and field strength across all segments/lobes below.

Test-retest repeatability analysis by protocol and field strength across all segments/lobes.

Protocol	Field	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	1.0	0.8% (-18%, 19.7%)	22.0	0.963 (0.95, 0.973)	< 0.001
P01	3.0T	1.9	0.9% (-16.7%, 18.5%)	44.3	0.966 (0.954, 0.975)	< 0.001
P02	1.5T	1.0	0.5% (-21.2%, 22.3%)	24.8	0.95 (0.932, 0.963)	< 0.001
P02	3.0T	1.8	1.3% (-21.6%, 24.3%)	44.2	0.963 (0.948, 0.973)	< 0.001
P04	1.5T	1.8	1.8% (-21.4%, 25%)	25.4	0.945 (0.925, 0.959)	< 0.001
P04	3.0T	1.3	0.3% (-27.4%, 28%)	54.3	0.953 (0.935, 0.966)	< 0.001
P08	1.5T	-1.1	-0.2% (-27.5%, 27.1%)	30.3	0.914 (0.883, 0.937)	< 0.001
P08	3.0T	1.4	2.3% (-28.1%, 32.6%)	49.5	0.952 (0.933, 0.965)	< 0.001

By lobe

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol, field strength, and lobe below.

Test-retest repeatability analysis by protocol, field strength, and lobe.

Protocol	Field	Lobe	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	Left	1.4	1.1% (-21.1%, 23.4%)	26.5	0.949 (0.924, 0.966)	< 0.001
P01	1.5T	Right	0.5	0.5% (-13%, 14%)	14.7	0.983 (0.973, 0.989)	< 0.001
P01	3.0T	Left	1.6	0.9% (-18.4%, 20.1%)	51.2	0.958 (0.937, 0.972)	< 0.001
P01	3.0T	Right	2.3	0.9% (-14.6%, 16.4%)	34.0	0.978 (0.965, 0.986)	< 0.001
P02	1.5T	Left	1.8	1.3% (-21.1%, 23.7%)	28.3	0.938 (0.907, 0.959)	< 0.001
P02	1.5T	Right	0.1	-0.4% (-21.3%, 20.4%)	19.8	0.967 (0.948, 0.979)	< 0.001
P02	3.0T	Left	2.5	1.4% (-22.3%, 25.1%)	47.8	0.961 (0.941, 0.975)	< 0.001
P02	3.0T	Right	0.8	1.2% (-20.9%, 23.3%)	39.6	0.965 (0.943, 0.979)	< 0.001
P04	1.5T	Left	1.8	2.3% (-24.9%, 29.5%)	27.4	0.939 (0.909, 0.96)	< 0.001
P04	1.5T	Right	1.9	1.1% (-16%, 18.3%)	22.9	0.953 (0.926, 0.97)	< 0.001
P04	3.0T	Left	2.1	0.6% (-32.7%, 33.9%)	61.3	0.944 (0.914, 0.964)	< 0.001
P04	3.0T	Right	0.3	-0.1% (-18.7%, 18.5%)	44.4	0.966 (0.946, 0.979)	< 0.001
P08	1.5T	Left	-0.5	1.2% (-29.8%, 32.3%)	33.3	0.9 (0.85, 0.933)	< 0.001
P08	1.5T	Right	-1.9	-2% (-23.5%, 19.5%)	26.3	0.933 (0.894, 0.958)	< 0.001
P08	3.0T	Left	2.6	3.6% (-31.3%, 38.5%)	56.0	0.935 (0.9, 0.958)	< 0.001
P08	3.0T	Right	-0.1	0.6% (-22.7%, 23.8%)	40.3	0.971 (0.952, 0.982)	< 0.001

Reproducibility analysis

Overall

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized across all segments/lobes below.

Between-protocol reproducibility analysis across all segments/lobes for smaller values.

Field	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	P01	P02	6.0	5.4% (-16.8%, 27.5%)	27.0	0.925 (0.908, 0.939)
		P03	2.4	2.1% (-18.6%, 22.8%)	24.9	0.937 (0.915, 0.954)
		P04	3.1	2.7% (-18.7%, 24.1%)	26.5	0.936 (0.921, 0.948)
		P05	8.8	8.7% (-14.8%, 32.3%)	28.7	0.888 (0.853, 0.916)
		P06	6.9	6.8% (-21.5%, 35%)	29.7	0.894 (0.859, 0.921)
		P07	8.5	8.1% (-12.4%, 28.6%)	26.5	0.899 (0.868, 0.923)
		P08	7.9	7% (-15.5%, 29.6%)	29.5	0.899 (0.878, 0.917)
		P09	5.4	4.7% (-19.1%, 28.4%)	31.9	0.908 (0.869, 0.936)
		P10	5.7	4.9% (-17.6%, 27.4%)	32.2	0.913 (0.875, 0.941)
	P02	P03	-6.4	-6.4% (-38.8%, 26%)	28.1	0.893 (0.858, 0.92)
		P04	-4.0	-4.2% (-33.7%, 25.4%)	26.6	0.928 (0.911, 0.941)
		P05	0.2	0.2% (-33.1%, 33.5%)	27.2	0.91 (0.879, 0.933)
		P06	-2.7	-2.5% (-42.2%, 37.1%)	35.1	0.849 (0.8, 0.887)
		P07	-0.1	-0.3% (-31.7%, 31.1%)	25.4	0.918 (0.89, 0.939)
		P08	0.8	0.3% (-32.1%, 32.7%)	32.2	0.895 (0.871, 0.914)
		P09	-4.7	-5.4% (-43.5%, 32.8%)	36.3	0.856 (0.796, 0.899)
		P10	-6.0	-6.6% (-47.5%, 34.2%)	36.0	0.862 (0.802, 0.904)
	P03	P04	0.5	0.3% (-14.9%, 15.5%)	15.0	0.975 (0.966, 0.981)
		P05	6.5	6.6% (-10.7%, 24%)	17.9	0.945 (0.927, 0.959)
		P06	3.6	3.8% (-20.2%, 27.8%)	24.5	0.927 (0.901, 0.945)
		P07	6.3	6.1% (-8.5%, 20.7%)	15.1	0.955 (0.941, 0.966)
		P08	5.3	5.2% (-12.9%, 23.2%)	19.5	0.943 (0.924, 0.958)
		P09	3.0	2.9% (-21.5%, 27.3%)	27.0	0.925 (0.893, 0.948)
		P10	2.6	2.6% (-19.1%, 24.3%)	21.6	0.955 (0.934, 0.969)
	P04	P05	6.0	6.3% (-11%, 23.7%)	16.7	0.951 (0.934, 0.963)
		P06	3.1	3.5% (-19.2%, 26.2%)	23.0	0.934 (0.912, 0.951)
		P07	5.8	5.8% (-9.5%, 21.1%)	15.3	0.956 (0.942, 0.967)
		P08	5.2	4.8% (-15.1%, 24.7%)	22.2	0.939 (0.925, 0.95)
		P09	1.9	1.9% (-21.7%, 25.4%)	28.0	0.92 (0.885, 0.944)
		P10	1.2	1.3% (-19.9%, 22.4%)	23.3	0.948 (0.924, 0.965)
	P05	P06	-2.9	-2.8% (-26.7%, 21.1%)	23.8	0.929 (0.904, 0.947)
		P07	-0.2	-0.5% (-17.9%, 16.9%)	15.7	0.969 (0.957, 0.977)
		P08	-1.2	-1.5% (-19.6%, 16.6%)	17.3	0.962 (0.949, 0.972)
		P09	-3.3	-3.7% (-30%, 22.5%)	30.2	0.901 (0.859, 0.931)
		P10	-4.2	-4.7% (-28.4%, 19.1%)	24.6	0.935 (0.905, 0.956)
	P06	P07	2.7	2.3% (-19.9%, 24.5%)	21.6	0.939 (0.918, 0.955)
		P08	1.7	1.4% (-23.2%, 25.9%)	23.4	0.932 (0.909, 0.95)
		P09	-0.2	-0.6% (-31.3%, 30%)	32.3	0.894 (0.848, 0.926)
		P10	-0.6	-1% (-31.3%, 29.2%)	29.0	0.921 (0.884, 0.946)
	P07	P08	-1.0	-0.9% (-18.7%, 16.8%)	16.9	0.963 (0.95, 0.973)
		P09	-3.1	-3.2% (-26.5%, 20.2%)	25.5	0.926 (0.895, 0.948)
		P10	-3.9	-3.9% (-25.8%, 18%)	21.8	0.947 (0.922, 0.963)
	P08	P09	-2.5	-2.5% (-22.4%, 17.3%)	22.7	0.943 (0.918, 0.961)
		P10	-3.1	-3.2% (-24.2%, 17.8%)	23.5	0.942 (0.916, 0.961)
	P09	P10	-0.6	-0.6% (-23.8%, 22.7%)	25.6	0.939 (0.91, 0.958)
3.0T	P01	P02	9.1	4.5% (-17.5%, 26.5%)	35.4	0.949 (0.938, 0.959)
		P03	-0.5	-1.1% (-27.3%, 25.1%)	38.7	0.959 (0.944, 0.969)
		P04	-0.4	-0.3% (-26.3%, 25.7%)	44.0	0.94 (0.925, 0.952)
		P05	7.2	3.5% (-26.3%, 33.3%)	44.0	0.94 (0.92, 0.955)
		P06	9.5	3.7% (-22.1%, 29.5%)	45.0	0.929 (0.908, 0.946)
		P07	11.1	5.7% (-21.9%, 33.3%)	42.6	0.934 (0.913, 0.95)
		P08	8.5	4.2% (-24.2%, 32.6%)	45.9	0.923 (0.904, 0.938)
		P09	-18.0	-8.9% (-56.7%, 38.9%)	95.7	0.786 (0.703, 0.847)
		P10	5.1	1.5% (-31.7%, 34.7%)	48.8	0.945 (0.92, 0.962)
	P02	P03	-8.8	-4.9% (-30.6%, 20.9%)	45.0	0.933 (0.91, 0.95)
		P04	-9.0	-4.6% (-28%, 18.8%)	41.5	0.935 (0.919, 0.947)
		P05	-0.6	-0.2% (-25.5%, 25.2%)	41.0	0.949 (0.931, 0.962)
		P06	1.3	0% (-23.7%, 23.7%)	39.8	0.949 (0.931, 0.962)
		P07	4.0	2.3% (-25.1%, 29.8%)	51.0	0.915 (0.885, 0.937)
		P08	-0.1	-0.2% (-25.3%, 24.9%)	40.2	0.944 (0.929, 0.955)
		P09	-24.2	-11.6% (-55.8%, 32.6%)	89.2	0.78 (0.699, 0.841)
		P10	-1.9	-1.3% (-34.6%, 32%)	47.3	0.947 (0.922, 0.964)
	P03	P04	0.7	0.5% (-22.4%, 23.4%)	40.3	0.955 (0.939, 0.967)
		P05	8.2	4.7% (-16.6%, 26%)	37.9	0.952 (0.935, 0.964)
		P06	10.1	4.9% (-16.9%, 26.7%)	41.4	0.937 (0.917, 0.953)
		P07	13.0	7.2% (-20.7%, 35.2%)	50.1	0.907 (0.876, 0.93)
		P08	10.5	5.7% (-21.7%, 33.2%)	45.3	0.927 (0.902, 0.946)
		P09	-16.0	-6.4% (-56.4%, 43.7%)	101.4	0.755 (0.664, 0.824)
		P10	6.2	3.8% (-34.3%, 41.8%)	58.2	0.918 (0.881, 0.944)
	P04	P05	7.5	4.2% (-22.1%, 30.4%)	42.2	0.943 (0.924, 0.958)
		P06	9.3	4.3% (-20.3%, 29%)	45.4	0.928 (0.905, 0.946)
		P07	12.2	6.7% (-21%, 34.4%)	51.0	0.906 (0.875, 0.93)
		P08	8.5	4.3% (-23.4%, 32%)	46.0	0.922 (0.904, 0.938)
		P09	-16.5	-6.9% (-55.9%, 42%)	97.8	0.772 (0.685, 0.837)
		P10	5.5	3% (-34.1%, 40.2%)	56.6	0.924 (0.889, 0.948)
	P05	P06	1.8	0.2% (-25.6%, 25.9%)	47.1	0.93 (0.906, 0.948)
		P07	4.5	2.5% (-25.7%, 30.7%)	43.3	0.938 (0.917, 0.954)
		P08	3.2	1.3% (-25.9%, 28.5%)	41.2	0.947 (0.928, 0.961)
		P09	-24.5	-11.7% (-61.2%, 37.7%)	96.6	0.749 (0.659, 0.818)
		P10	-2.5	-1.5% (-40.4%, 37.3%)	52.5	0.934 (0.903, 0.955)
	P06	P07	2.9	2.4% (-24.1%, 28.8%)	55.0	0.899 (0.864, 0.925)
		P08	0.6	1% (-26.4%, 28.4%)	46.1	0.93 (0.905, 0.948)
		P09	-24.6	-10.8% (-58.8%, 37.2%)	98.4	0.732 (0.639, 0.804)
		P10	-3.2	-0.9% (-34.7%, 32.8%)	55.1	0.924 (0.89, 0.948)
	P07	P08	-1.7	-1.3% (-25.4%, 22.8%)	43.8	0.939 (0.917, 0.955)
		P09	-28.4	-13.8% (-58.2%, 30.6%)	93.5	0.739 (0.648, 0.808)
		P10	-6.9	-4.1% (-40.5%, 32.2%)	62.4	0.899 (0.853, 0.931)
	P08	P09	-27.7	-12.8% (-61.7%, 36%)	97.8	0.738 (0.643, 0.81)
		P10	-3.6	-1.9% (-44.5%, 40.7%)	60.4	0.912 (0.87, 0.941)
	P09	P10	18.5	7.8% (-44.1%, 59.6%)	98.5	0.776 (0.688, 0.841)

By lobe

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized by lobe below.

Between-protocol reproducibility analysis of R2* by lobe for smaller values.

Field	Lobe	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	Left	P01	P02	5.2	4.7% (-18.7%, 28%)	26.1	0.933 (0.912, 0.95)
			P03	1.6	1.6% (-19.2%, 22.5%)	22.9	0.942 (0.913, 0.962)
			P04	3.2	2.9% (-19.8%, 25.5%)	27.5	0.93 (0.908, 0.947)
			P05	8.5	8.9% (-13.2%, 31%)	25.9	0.895 (0.846, 0.928)
			P06	6.9	6.7% (-22.1%, 35.5%)	30.3	0.872 (0.814, 0.913)
			P07	7.7	7.7% (-13%, 28.4%)	23.4	0.911 (0.87, 0.939)
			P08	8.3	7.2% (-16.3%, 30.8%)	30.2	0.891 (0.86, 0.916)
			P09	6.1	4.8% (-18.3%, 28%)	27.9	0.907 (0.855, 0.941)
			P10	6.0	5.6% (-15.2%, 26.4%)	25.6	0.931 (0.885, 0.958)
		P02	P03	-5.6	-5.7% (-36.9%, 25.6%)	27.3	0.895 (0.846, 0.929)
			P04	-2.9	-3.1% (-34.9%, 28.8%)	29.4	0.915 (0.888, 0.936)
			P05	1.2	1.5% (-30.4%, 33.3%)	25.8	0.912 (0.869, 0.941)
			P06	-1.6	-1.7% (-40%, 36.5%)	33.2	0.851 (0.782, 0.899)
			P07	0.7	0.6% (-29%, 30.3%)	24.0	0.922 (0.885, 0.948)
			P08	2.1	1.4% (-32.1%, 34.9%)	34.4	0.877 (0.84, 0.906)
			P09	-2.1	-3.5% (-40.1%, 33.1%)	33.0	0.865 (0.785, 0.916)
			P10	-4.4	-4.9% (-46.9%, 37.1%)	36.7	0.848 (0.754, 0.908)
		P03	P04	0.2	0.1% (-17.5%, 17.8%)	16.7	0.967 (0.95, 0.978)
			P05	6.9	7.2% (-10.3%, 24.6%)	17.3	0.941 (0.914, 0.96)
			P06	4.0	3.9% (-21.1%, 28.9%)	24.3	0.918 (0.879, 0.944)
			P07	6.4	6.3% (-9.5%, 22.1%)	15.2	0.952 (0.93, 0.967)
			P08	5.1	5.1% (-15.1%, 25.2%)	21.3	0.932 (0.899, 0.954)
			P09	4.1	3.4% (-22.8%, 29.5%)	27.2	0.904 (0.847, 0.94)
			P10	3.1	3.2% (-18.5%, 24.9%)	20.4	0.953 (0.922, 0.972)
		P04	P05	6.7	7% (-9.4%, 23.4%)	16.3	0.946 (0.921, 0.963)
			P06	3.8	3.8% (-20%, 27.5%)	23.2	0.924 (0.888, 0.949)
			P07	6.1	6.2% (-10.2%, 22.6%)	16.3	0.948 (0.924, 0.964)
			P08	5.4	4.9% (-15.2%, 25%)	22.7	0.933 (0.911, 0.949)
			P09	3.5	2.7% (-21.1%, 26.5%)	26.0	0.913 (0.861, 0.946)
			P10	2.0	2% (-18.5%, 22.5%)	22.5	0.946 (0.909, 0.968)
		P05	P06	-2.9	-3.2% (-28.3%, 21.8%)	24.6	0.914 (0.872, 0.942)
			P07	-0.5	-0.8% (-18.1%, 16.5%)	15.6	0.967 (0.95, 0.978)
			P08	-1.7	-2.1% (-19.6%, 15.3%)	16.8	0.961 (0.942, 0.974)
			P09	-3.1	-4.5% (-29.3%, 20.3%)	23.3	0.926 (0.879, 0.955)
			P10	-4.7	-5.4% (-27.2%, 16.4%)	22.1	0.937 (0.895, 0.962)
		P06	P07	2.4	2.4% (-21.5%, 26.3%)	22.3	0.928 (0.893, 0.952)
			P08	1.1	1.1% (-26.2%, 28.4%)	26.9	0.901 (0.854, 0.934)
			P09	0.4	-0.5% (-32.8%, 31.8%)	31.3	0.871 (0.793, 0.921)
			P10	-0.8	-0.9% (-28.9%, 27%)	26.1	0.923 (0.873, 0.954)
		P07	P08	-1.2	-1.3% (-20.9%, 18.3%)	19.3	0.949 (0.923, 0.966)
			P09	-2.0	-2.8% (-27.7%, 22.2%)	23.0	0.928 (0.883, 0.956)
			P10	-3.4	-3.5% (-26.8%, 19.8%)	22.8	0.936 (0.894, 0.962)
		P08	P09	-1.7	-2.5% (-22.4%, 17.5%)	19.0	0.952 (0.921, 0.971)
			P10	-3.2	-3.2% (-24.9%, 18.4%)	24.2	0.93 (0.884, 0.959)
		P09	P10	-1.5	-0.7% (-25.7%, 24.4%)	25.4	0.925 (0.876, 0.955)
	Right	P01	P02	7.0	6.2% (-14.2%, 26.7%)	28.1	0.915 (0.886, 0.938)
			P03	3.3	2.7% (-17.9%, 23.2%)	27.4	0.932 (0.894, 0.957)
			P04	3.0	2.6% (-17.2%, 22.3%)	25.3	0.943 (0.922, 0.958)
			P05	9.2	8.6% (-16.9%, 34%)	32.0	0.882 (0.821, 0.922)
			P06	6.8	6.8% (-20.9%, 34.5%)	29.2	0.913 (0.866, 0.945)
			P07	9.5	8.5% (-11.9%, 28.9%)	29.9	0.887 (0.832, 0.924)
			P08	7.6	6.8% (-14.5%, 28.1%)	28.8	0.909 (0.877, 0.933)
			P09	4.7	4.5% (-20.3%, 29.3%)	36.6	0.909 (0.841, 0.948)
			P10	5.2	4.1% (-20.5%, 28.6%)	39.2	0.898 (0.822, 0.942)
		P02	P03	-7.2	-7.3% (-41.3%, 26.7%)	29.1	0.89 (0.832, 0.929)
			P04	-5.4	-5.6% (-31.8%, 20.7%)	22.3	0.943 (0.922, 0.958)
			P05	-1.2	-1.4% (-36.4%, 33.7%)	28.7	0.907 (0.856, 0.941)
			P06	-4.1	-3.6% (-45.1%, 38%)	37.5	0.848 (0.769, 0.901)
			P07	-1.0	-1.5% (-35.1%, 32.1%)	27.1	0.913 (0.865, 0.945)
			P08	-0.8	-1.1% (-32.1%, 29.8%)	29.0	0.916 (0.885, 0.939)
			P09	-7.9	-7.7% (-47.7%, 32.3%)	39.6	0.848 (0.751, 0.91)
			P10	-8.1	-8.8% (-48.1%, 30.6%)	35.1	0.875 (0.786, 0.929)
		P03	P04	0.8	0.6% (-11%, 12.1%)	12.5	0.983 (0.974, 0.989)
			P05	6.0	6% (-11.2%, 23.2%)	18.6	0.949 (0.921, 0.967)
			P06	3.1	3.7% (-19.2%, 26.6%)	25.0	0.935 (0.898, 0.958)
			P07	6.2	5.8% (-7.2%, 18.9%)	15.0	0.959 (0.939, 0.973)
			P08	5.5	5.3% (-9.8%, 20.5%)	17.2	0.956 (0.932, 0.971)
			P09	1.6	2.3% (-19.8%, 24.4%)	26.7	0.943 (0.901, 0.967)
			P10	1.9	1.8% (-20%, 23.6%)	23.3	0.956 (0.922, 0.976)
		P04	P05	5.3	5.5% (-13%, 23.9%)	17.2	0.956 (0.932, 0.972)
			P06	2.4	3.2% (-18.4%, 24.7%)	22.9	0.945 (0.913, 0.965)
			P07	5.4	5.3% (-8.6%, 19.2%)	13.9	0.965 (0.946, 0.977)
			P08	4.9	4.7% (-15%, 24.4%)	21.6	0.945 (0.925, 0.96)
			P09	-0.1	0.9% (-22.5%, 24.2%)	30.0	0.926 (0.873, 0.957)
			P10	0.3	0.4% (-21.6%, 22.4%)	24.3	0.951 (0.912, 0.973)
		P05	P06	-2.9	-2.3% (-24.9%, 20.3%)	22.8	0.943 (0.911, 0.963)
			P07	0.2	-0.2% (-17.8%, 17.5%)	16.0	0.97 (0.953, 0.981)
			P08	-0.5	-0.7% (-19.6%, 18.2%)	18.0	0.963 (0.942, 0.977)
			P09	-3.4	-2.8% (-30.9%, 25.3%)	37.3	0.881 (0.8, 0.931)
			P10	-3.5	-3.7% (-29.8%, 22.4%)	27.6	0.933 (0.881, 0.963)
		P06	P07	3.1	2.1% (-17.8%, 22%)	20.8	0.949 (0.923, 0.967)
			P08	2.4	1.6% (-19.1%, 22.3%)	18.3	0.963 (0.942, 0.976)
			P09	-0.8	-0.8% (-29.5%, 27.9%)	33.9	0.91 (0.846, 0.949)
			P10	-0.3	-1.2% (-34.4%, 32%)	32.6	0.918 (0.856, 0.954)
		P07	P08	-0.7	-0.5% (-15.7%, 14.6%)	13.5	0.978 (0.965, 0.986)
			P09	-4.5	-3.6% (-25.1%, 17.8%)	28.3	0.924 (0.874, 0.955)
			P10	-4.4	-4.4% (-24.6%, 15.8%)	20.7	0.957 (0.924, 0.976)
		P08	P09	-3.4	-2.6% (-22.5%, 17.2%)	26.8	0.936 (0.891, 0.962)
			P10	-3.0	-3.1% (-23.5%, 17.4%)	22.8	0.953 (0.917, 0.974)
		P09	P10	0.5	-0.4% (-21.5%, 20.7%)	25.9	0.95 (0.911, 0.972)
3.0T	Left	P01	P02	9.1	4.9% (-15.8%, 25.6%)	35.3	0.947 (0.929, 0.96)
			P03	1.3	0.6% (-21.2%, 22.4%)	35.8	0.962 (0.943, 0.975)
			P04	-0.8	-0.2% (-25.9%, 25.5%)	44.0	0.938 (0.916, 0.954)
			P05	6.9	3.8% (-19.6%, 27.2%)	40.5	0.945 (0.919, 0.963)
			P06	9.0	4.1% (-19.7%, 27.9%)	46.4	0.922 (0.886, 0.947)
			P07	11.0	6% (-15.6%, 27.7%)	39.8	0.938 (0.909, 0.958)
			P08	7.3	3.8% (-18.3%, 25.9%)	39.0	0.942 (0.922, 0.957)
			P09	-21.4	-9.5% (-55.2%, 36.2%)	95.3	0.766 (0.644, 0.85)
			P10	4.1	1.6% (-30.6%, 33.9%)	51.5	0.932 (0.888, 0.96)
		P02	P03	-6.7	-3.6% (-28.9%, 21.8%)	47.4	0.923 (0.886, 0.948)
			P04	-9.7	-5.1% (-28%, 17.9%)	40.9	0.93 (0.908, 0.948)
			P05	-1.1	-0.4% (-23.9%, 23.1%)	42.8	0.939 (0.909, 0.959)
			P06	1.0	0% (-25.2%, 25.2%)	42.9	0.935 (0.904, 0.957)
			P07	3.0	1.9% (-25.7%, 29.4%)	50.3	0.914 (0.873, 0.943)
			P08	-1.7	-1.1% (-27.1%, 24.9%)	39.4	0.943 (0.923, 0.958)
			P09	-28.6	-13.2% (-59.7%, 33.3%)	93.0	0.735 (0.609, 0.824)
			P10	-3.1	-1.9% (-34.8%, 30.9%)	50.0	0.93 (0.884, 0.959)
		P03	P04	-2.5	-1.6% (-23.6%, 20.5%)	40.3	0.95 (0.925, 0.967)
			P05	5.6	3.2% (-18.1%, 24.5%)	38.7	0.95 (0.925, 0.967)
			P06	7.7	3.5% (-21.4%, 28.4%)	47.6	0.919 (0.881, 0.945)
			P07	9.7	5.4% (-19.3%, 30.2%)	40.5	0.938 (0.908, 0.958)
			P08	8.2	4.5% (-25.5%, 34.4%)	50.0	0.916 (0.875, 0.944)
			P09	-24.0	-10.4% (-61.4%, 40.6%)	103.5	0.712 (0.572, 0.812)
			P10	1.1	0.5% (-35.4%, 36.5%)	60.9	0.903 (0.839, 0.942)
		P04	P05	8.1	4.7% (-18.7%, 28.1%)	41.0	0.94 (0.911, 0.96)
			P06	10.2	5.1% (-19.7%, 29.9%)	47.5	0.913 (0.873, 0.941)
			P07	12.2	7% (-17.8%, 31.7%)	44.4	0.921 (0.884, 0.947)
			P08	7.7	3.8% (-24.9%, 32.6%)	45.8	0.922 (0.896, 0.942)
			P09	-20.3	-8.3% (-57.1%, 40.5%)	97.6	0.749 (0.622, 0.838)
			P10	5.0	2.7% (-32.6%, 38%)	59.0	0.906 (0.845, 0.944)
		P05	P06	2.1	0.4% (-26.4%, 27.1%)	52.2	0.907 (0.863, 0.938)
			P07	4.1	2.3% (-23.4%, 27.9%)	40.8	0.944 (0.916, 0.963)
			P08	3.5	1.8% (-25.3%, 28.8%)	42.8	0.941 (0.911, 0.961)
			P09	-30.9	-14.6% (-63.6%, 34.4%)	95.5	0.719 (0.588, 0.813)
			P10	-6.0	-3.6% (-37.7%, 30.4%)	51.2	0.926 (0.877, 0.956)
		P06	P07	1.9	1.9% (-24.4%, 28.2%)	54.1	0.899 (0.852, 0.932)
			P08	0.8	1.2% (-29.7%, 32.1%)	53.5	0.904 (0.856, 0.936)
			P09	-30.4	-13.3% (-64%, 37.4%)	103.2	0.677 (0.534, 0.783)
			P10	-6.0	-2.7% (-37.4%, 32%)	62.5	0.887 (0.814, 0.932)
		P07	P08	-1.6	-1% (-26%, 23.9%)	51.1	0.916 (0.874, 0.945)
			P09	-32.0	-15.4% (-60.2%, 29.4%)	92.9	0.728 (0.6, 0.819)
			P10	-7.7	-4.9% (-39.5%, 29.8%)	57.2	0.908 (0.848, 0.945)
		P08	P09	-33.8	-16.2% (-66.1%, 33.7%)	99.7	0.707 (0.568, 0.807)
			P10	-6.6	-4.3% (-47%, 38.4%)	62.2	0.899 (0.829, 0.941)
		P09	P10	21.7	8.5% (-45.8%, 62.9%)	102.5	0.739 (0.602, 0.833)
	Right	P01	P02	9.2	4% (-19.7%, 27.7%)	35.6	0.952 (0.936, 0.965)
			P03	-2.9	-3.3% (-33.8%, 27.2%)	42.0	0.955 (0.93, 0.971)
			P04	0.0	-0.4% (-27%, 26.1%)	44.2	0.942 (0.919, 0.958)
			P05	7.6	3.1% (-33.4%, 39.6%)	48.5	0.935 (0.9, 0.958)
			P06	10.1	3.2% (-25.1%, 31.5%)	43.5	0.938 (0.91, 0.957)
			P07	11.3	5.3% (-28.5%, 39%)	46.2	0.93 (0.893, 0.954)
			P08	10.2	4.7% (-30.1%, 39.6%)	53.2	0.901 (0.865, 0.928)
			P09	-13.5	-8% (-58.8%, 42.8%)	96.4	0.808 (0.683, 0.887)
			P10	6.3	1.3% (-33.5%, 36.1%)	45.7	0.957 (0.928, 0.974)
		P02	P03	-11.4	-6.5% (-32.5%, 19.5%)	41.6	0.942 (0.91, 0.963)
			P04	-8.2	-4.1% (-28.2%, 19.9%)	42.2	0.939 (0.915, 0.956)
			P05	0.1	0.1% (-27.5%, 27.7%)	38.7	0.959 (0.935, 0.974)
			P06	1.5	0% (-21.9%, 21.9%)	35.9	0.963 (0.942, 0.976)
			P07	5.3	2.9% (-24.6%, 30.4%)	52.1	0.915 (0.867, 0.946)
			P08	1.8	1% (-22.9%, 24.9%)	40.9	0.945 (0.922, 0.961)
			P09	-18.7	-9.6% (-50.8%, 31.6%)	84.0	0.831 (0.721, 0.9)
			P10	-0.4	-0.5% (-34.6%, 33.6%)	44.0	0.962 (0.931, 0.979)
		P03	P04	4.7	3.1% (-19.9%, 26.2%)	39.0	0.96 (0.937, 0.975)
			P05	11.5	6.6% (-14.3%, 27.5%)	36.1	0.953 (0.927, 0.97)
			P06	13.0	6.5% (-10.3%, 23.3%)	31.3	0.956 (0.934, 0.971)
			P07	17.3	9.5% (-21.6%, 40.7%)	59.3	0.871 (0.806, 0.915)
			P08	13.4	7.3% (-16.4%, 31.1%)	38.2	0.939 (0.906, 0.961)
			P09	-5.9	-1.4% (-48.8%, 46.1%)	96.2	0.807 (0.68, 0.887)
			P10	12.5	7.8% (-31.7%, 47.3%)	52.7	0.933 (0.882, 0.963)
		P04	P05	6.8	3.5% (-26.1%, 33.1%)	43.7	0.946 (0.916, 0.966)
			P06	8.2	3.4% (-21.1%, 27.9%)	43.0	0.943 (0.914, 0.963)
			P07	12.2	6.3% (-25%, 37.6%)	58.6	0.889 (0.831, 0.928)
			P08	9.5	4.9% (-21.5%, 31.2%)	46.3	0.922 (0.892, 0.944)
			P09	-11.8	-5.2% (-54.7%, 44.2%)	98.2	0.797 (0.666, 0.88)
			P10	6.2	3.5% (-36.3%, 43.3%)	54.1	0.941 (0.894, 0.967)
		P05	P06	1.5	-0.1% (-24.7%, 24.5%)	40.3	0.953 (0.927, 0.97)
			P07	5.1	2.7% (-28.6%, 34.1%)	46.5	0.932 (0.893, 0.957)
			P08	2.7	0.8% (-26.8%, 28.3%)	39.4	0.954 (0.928, 0.971)
			P09	-16.5	-8.1% (-57.6%, 41.5%)	96.6	0.785 (0.651, 0.872)
			P10	1.9	1.1% (-42.9%, 45.1%)	53.4	0.941 (0.895, 0.968)
		P06	P07	4.1	3% (-23.8%, 29.7%)	56.4	0.898 (0.841, 0.935)
			P08	0.3	0.7% (-21.7%, 23.1%)	35.0	0.961 (0.937, 0.976)
			P09	-17.5	-7.6% (-51.7%, 36.5%)	91.3	0.798 (0.671, 0.879)
			P10	0.3	1.2% (-31.1%, 33.5%)	43.7	0.96 (0.928, 0.978)
		P07	P08	-1.9	-1.7% (-24.8%, 21.4%)	32.6	0.967 (0.947, 0.98)
			P09	-23.7	-11.8% (-55.9%, 32.2%)	94.5	0.753 (0.607, 0.849)
			P10	-5.9	-3.2% (-41.9%, 35.6%)	69.2	0.888 (0.804, 0.937)
		P08	P09	-20.0	-8.5% (-55.3%, 38.2%)	94.4	0.78 (0.638, 0.87)
			P10	0.2	1.2% (-41.1%, 43.4%)	57.9	0.927 (0.867, 0.961)
		P09	P10	14.6	6.8% (-42.3%, 56%)	93.7	0.818 (0.692, 0.895)

LIC (3.2,7]

This section looks into the repeatability and reproducibility for subjects with LIC \(\in\) (3.2,7].

Repeatability analysis

The number of pairs for test-retest repeatability analysis by protocol, field strength, and lobe is listed below.

Overall

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol and field strength across all segments/lobes below.

Test-retest repeatability analysis by protocol and field strength across all segments/lobes.

Protocol	Field	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	0.2	0.2% (-10.5%, 10.8%)	27.2	0.989 (0.985, 0.992)	< 0.001
P01	3.0T	2.8	0.6% (-10.1%, 11.2%)	55.3	0.988 (0.983, 0.991)	< 0.001
P02	1.5T	-2.3	-0.8% (-14.1%, 12.6%)	32.5	0.982 (0.976, 0.986)	< 0.001
P02	3.0T	4.5	0.9% (-14.2%, 15.9%)	73.9	0.974 (0.965, 0.98)	< 0.001
P04	1.5T	3.3	1.6% (-13.1%, 16.4%)	36.5	0.976 (0.968, 0.982)	< 0.001
P04	3.0T	-3.5	-0.8% (-15.6%, 14.1%)	68.0	0.977 (0.968, 0.983)	< 0.001
P08	1.5T	-0.6	0% (-15.7%, 15.7%)	40.3	0.966 (0.955, 0.975)	< 0.001
P08	3.0T	3.9	0.9% (-16.3%, 18.2%)	71.8	0.958 (0.944, 0.969)	< 0.001

By lobe

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol, field strength, and lobe below.

Test-retest repeatability analysis by protocol, field strength, and lobe.

Protocol	Field	Lobe	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	Left	-0.3	0.1% (-12.1%, 12.4%)	32.1	0.985 (0.978, 0.99)	< 0.001
P01	1.5T	Right	0.8	0.2% (-8%, 8.5%)	19.6	0.994 (0.991, 0.996)	< 0.001
P01	3.0T	Left	2.5	0.6% (-11.1%, 12.3%)	65.0	0.982 (0.973, 0.988)	< 0.001
P01	3.0T	Right	3.1	0.6% (-8.6%, 9.7%)	40.3	0.994 (0.991, 0.996)	< 0.001
P02	1.5T	Left	-1.7	-0.4% (-14.9%, 14.1%)	37.8	0.976 (0.965, 0.984)	< 0.001
P02	1.5T	Right	-3.0	-1.3% (-13%, 10.5%)	24.5	0.989 (0.983, 0.993)	< 0.001
P02	3.0T	Left	8.5	2% (-15.1%, 19.1%)	83.3	0.963 (0.946, 0.975)	< 0.001
P02	3.0T	Right	-0.4	-0.6% (-12.2%, 11%)	59.3	0.985 (0.977, 0.99)	< 0.001
P04	1.5T	Left	3.8	2% (-14%, 18%)	40.3	0.971 (0.957, 0.98)	< 0.001
P04	1.5T	Right	2.6	1.1% (-11.9%, 14.1%)	31.3	0.983 (0.974, 0.989)	< 0.001
P04	3.0T	Left	-5.3	-1% (-17%, 15%)	73.3	0.969 (0.953, 0.979)	< 0.001
P04	3.0T	Right	-1.2	-0.5% (-13.9%, 12.9%)	60.9	0.984 (0.975, 0.99)	< 0.001
P08	1.5T	Left	1.2	0.5% (-17.8%, 18.7%)	46.0	0.955 (0.935, 0.97)	< 0.001
P08	1.5T	Right	-2.8	-0.7% (-12.4%, 11%)	31.5	0.98 (0.969, 0.987)	< 0.001
P08	3.0T	Left	-0.3	0.1% (-18.2%, 18.4%)	72.7	0.953 (0.93, 0.969)	< 0.001
P08	3.0T	Right	9.3	2% (-13.7%, 17.7%)	69.9	0.964 (0.943, 0.977)	< 0.001

Reproducibility analysis

Overall

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized across all segments/lobes below.

Between-protocol reproducibility analysis across all segments/lobes for smaller values.

Field	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	P01	P02	7.6	4.5% (-7.7%, 16.7%)	21.7	0.965 (0.956, 0.972)
		P03	4.3	2.6% (-16.9%, 22.1%)	27.7	0.96 (0.944, 0.972)
		P04	0.7	0.4% (-13.9%, 14.7%)	25.2	0.966 (0.956, 0.973)
		P05	11.2	6.9% (-6.3%, 20.1%)	23.3	0.955 (0.938, 0.968)
		P06	13.9	7.8% (-13.2%, 28.8%)	36.8	0.909 (0.873, 0.935)
		P07	13.7	8.1% (-6%, 22.2%)	25.6	0.94 (0.917, 0.957)
		P08	8.5	5.2% (-10.7%, 21.1%)	25.1	0.952 (0.939, 0.962)
		P09	10.1	6.4% (-13.2%, 25.9%)	33.8	0.931 (0.899, 0.953)
		P10	8.0	5.3% (-14.3%, 24.9%)	32.9	0.945 (0.92, 0.963)
	P02	P03	-2.8	-1.6% (-20.5%, 17.3%)	26.1	0.968 (0.955, 0.978)
		P04	-7.0	-4.1% (-17.6%, 9.3%)	23.5	0.963 (0.954, 0.971)
		P05	4.6	2.8% (-13.1%, 18.7%)	26.8	0.965 (0.95, 0.975)
		P06	7.5	3.9% (-15.6%, 23.4%)	35.2	0.939 (0.913, 0.957)
		P07	7.3	4.1% (-11%, 19.2%)	27.2	0.961 (0.945, 0.973)
		P08	1.0	0.6% (-14.3%, 15.6%)	24.3	0.971 (0.963, 0.977)
		P09	3.7	2.1% (-21.1%, 25.4%)	42.8	0.92 (0.883, 0.946)
		P10	0.5	0.8% (-18.3%, 19.8%)	33.9	0.952 (0.929, 0.967)
	P03	P04	-3.1	-1.7% (-19.5%, 16.2%)	26.9	0.967 (0.953, 0.977)
		P05	7.1	4.3% (-15.5%, 24.1%)	29.0	0.954 (0.935, 0.968)
		P06	9.0	4.8% (-16%, 25.6%)	36.9	0.932 (0.904, 0.952)
		P07	9.5	5.3% (-15.4%, 26.1%)	31.3	0.945 (0.922, 0.961)
		P08	5.6	3.4% (-15.3%, 22.1%)	30.4	0.955 (0.936, 0.968)
		P09	6.3	3.8% (-22.6%, 30.2%)	42.1	0.921 (0.886, 0.946)
		P10	4.6	3% (-24.3%, 30.3%)	39.9	0.932 (0.901, 0.954)
	P04	P05	10.5	6.1% (-9%, 21.3%)	28.5	0.947 (0.926, 0.962)
		P06	12.1	6.6% (-12.7%, 25.9%)	34.4	0.927 (0.898, 0.948)
		P07	12.9	7.2% (-10.7%, 25%)	34.2	0.924 (0.894, 0.946)
		P08	8.2	4.9% (-9.3%, 19%)	23.3	0.96 (0.95, 0.968)
		P09	7.7	4.8% (-19.2%, 28.8%)	42.5	0.917 (0.879, 0.943)
		P10	6.1	4.1% (-17.5%, 25.6%)	37.1	0.937 (0.908, 0.958)
	P05	P06	3.0	1% (-22%, 24%)	39.9	0.933 (0.905, 0.953)
		P07	2.6	1.1% (-14.7%, 17%)	28.5	0.965 (0.95, 0.975)
		P08	-1.6	-0.9% (-18%, 16.1%)	27.5	0.964 (0.949, 0.975)
		P09	-2.2	-1.3% (-23%, 20.4%)	36.8	0.944 (0.919, 0.962)
		P10	-3.5	-2% (-25.1%, 21.2%)	39.0	0.937 (0.908, 0.957)
	P06	P07	1.5	0.9% (-21%, 22.7%)	38.6	0.939 (0.913, 0.957)
		P08	-3.2	-1.5% (-20.4%, 17.5%)	34.5	0.946 (0.922, 0.962)
		P09	-3.4	-1.6% (-28.4%, 25.3%)	46.3	0.918 (0.879, 0.945)
		P10	-6.2	-2.9% (-28.1%, 22.3%)	44.0	0.923 (0.887, 0.948)
	P07	P08	-4.8	-2.4% (-22.4%, 17.6%)	32.9	0.947 (0.924, 0.963)
		P09	-3.8	-2% (-24.4%, 20.5%)	42.2	0.933 (0.901, 0.955)
		P10	-7.9	-3.9% (-26%, 18.2%)	39.6	0.932 (0.901, 0.954)
	P08	P09	-0.5	-0.3% (-24.1%, 23.5%)	40.7	0.926 (0.89, 0.95)
		P10	-1.6	-0.9% (-24%, 22.3%)	37.8	0.939 (0.911, 0.959)
	P09	P10	-1.1	-0.6% (-23.6%, 22.5%)	39.0	0.939 (0.91, 0.958)
3.0T	P01	P02	12.4	4.5% (-8.2%, 17.1%)	35.7	0.946 (0.93, 0.959)
		P03	6.5	2% (-15.4%, 19.3%)	50.7	0.929 (0.892, 0.954)
		P04	-0.1	-0.1% (-16.5%, 16.3%)	48.4	0.932 (0.91, 0.949)
		P05	19.0	7.3% (-14%, 28.5%)	61.6	0.887 (0.835, 0.923)
		P06	17.7	6.2% (-13.6%, 25.9%)	52.3	0.918 (0.877, 0.946)
		P07	18.9	7.4% (-12.1%, 26.8%)	55.0	0.907 (0.862, 0.938)
		P08	14.6	5.1% (-14.6%, 24.8%)	54.2	0.889 (0.856, 0.915)
		P09	3.3	1.6% (-22.6%, 25.8%)	65.3	0.91 (0.859, 0.943)
		P10	7.8	4% (-22%, 30.1%)	70.4	0.896 (0.841, 0.933)
	P02	P03	-6.6	-2.6% (-18.3%, 13%)	44.3	0.946 (0.918, 0.964)
		P04	-12.3	-4.5% (-20.4%, 11.4%)	45.4	0.924 (0.901, 0.942)
		P05	4.3	1.8% (-17.9%, 21.5%)	54.0	0.934 (0.902, 0.956)
		P06	4.9	1.3% (-18.9%, 21.5%)	53.4	0.939 (0.908, 0.96)
		P07	5.8	2.3% (-17.5%, 22.2%)	55.6	0.931 (0.896, 0.954)
		P08	2.3	0.6% (-20.5%, 21.7%)	56.8	0.906 (0.877, 0.928)
		P09	-9.2	-3.4% (-28.5%, 21.7%)	65.9	0.901 (0.846, 0.937)
		P10	-4.5	-0.8% (-23.3%, 21.6%)	60.1	0.925 (0.885, 0.951)
	P03	P04	-5.8	-1.5% (-19.9%, 16.8%)	52.6	0.927 (0.89, 0.952)
		P05	11.8	4.4% (-16.9%, 25.7%)	62.2	0.886 (0.83, 0.924)
		P06	10.7	3.8% (-15.9%, 23.4%)	55.4	0.916 (0.871, 0.946)
		P07	11.4	4.4% (-16.7%, 25.4%)	59.7	0.897 (0.842, 0.933)
		P08	15.4	5.6% (-18%, 29.3%)	61.8	0.875 (0.814, 0.916)
		P09	1.8	1.7% (-24.9%, 28.2%)	72.8	0.881 (0.813, 0.926)
		P10	-3.3	-0.1% (-24.2%, 23.9%)	69.1	0.884 (0.82, 0.926)
	P04	P05	17.3	6.3% (-16.7%, 29.4%)	65.6	0.887 (0.836, 0.923)
		P06	13.0	4.4% (-14.9%, 23.8%)	51.1	0.933 (0.899, 0.955)
		P07	17.7	6.7% (-18.5%, 31.9%)	68.8	0.876 (0.817, 0.917)
		P08	14.5	5.1% (-14%, 24.2%)	51.9	0.898 (0.868, 0.922)
		P09	4.5	1.7% (-27.9%, 31.3%)	77.2	0.878 (0.81, 0.922)
		P10	6.8	3.4% (-25.9%, 32.8%)	80.2	0.871 (0.803, 0.916)
	P05	P06	-1.3	-1.1% (-23%, 20.7%)	59.7	0.926 (0.889, 0.951)
		P07	-0.3	-0.1% (-22.2%, 22.1%)	64.7	0.911 (0.866, 0.941)
		P08	2.2	0.5% (-23.4%, 24.4%)	63.8	0.908 (0.864, 0.938)
		P09	-14.5	-5.6% (-37.7%, 26.5%)	85.4	0.837 (0.753, 0.894)
		P10	-8.9	-2.8% (-30.1%, 24.5%)	79.1	0.869 (0.8, 0.915)
	P06	P07	0.4	0.9% (-23.3%, 25.2%)	62.3	0.919 (0.876, 0.948)
		P08	4.3	1.8% (-19.8%, 23.5%)	55.9	0.931 (0.895, 0.954)
		P09	-12.0	-3.9% (-37.6%, 29.7%)	80.8	0.852 (0.767, 0.908)
		P10	-9.9	-2.1% (-34.3%, 30.1%)	84.6	0.847 (0.767, 0.901)
	P07	P08	2.2	0.4% (-28.2%, 29%)	73.6	0.876 (0.816, 0.918)
		P09	-14.0	-5.6% (-33.2%, 22%)	69.3	0.883 (0.818, 0.925)
		P10	-9.5	-3% (-26.4%, 20.3%)	64.0	0.911 (0.863, 0.943)
	P08	P09	-15.2	-5.2% (-36.8%, 26.4%)	82.4	0.827 (0.739, 0.887)
		P10	-12.8	-3.7% (-39.7%, 32.3%)	93.5	0.804 (0.71, 0.869)
	P09	P10	7.9	3.6% (-25.6%, 32.8%)	70.4	0.892 (0.831, 0.932)

By lobe

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized by lobe below.

Between-protocol reproducibility analysis of R2* by lobe for smaller values.

Field	Lobe	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	Left	P01	P02	7.6	4.4% (-8.6%, 17.3%)	24.4	0.957 (0.942, 0.969)
			P03	4.2	2.6% (-20.5%, 25.7%)	32.9	0.946 (0.913, 0.967)
			P04	-0.3	-0.1% (-15.7%, 15.6%)	27.8	0.959 (0.943, 0.97)
			P05	10.1	6.3% (-8.9%, 21.6%)	26.6	0.954 (0.928, 0.971)
			P06	15.6	8.4% (-16.1%, 33%)	42.0	0.885 (0.823, 0.926)
			P07	14.0	8.1% (-6.8%, 23%)	25.3	0.94 (0.907, 0.962)
			P08	8.0	5% (-14%, 24.1%)	28.9	0.942 (0.92, 0.958)
			P09	11.8	6.6% (-15.8%, 29%)	41.0	0.902 (0.841, 0.94)
			P10	7.7	5.1% (-14.5%, 24.7%)	35.4	0.938 (0.896, 0.963)
		P02	P03	-3.3	-1.6% (-20.5%, 17.3%)	26.1	0.966 (0.944, 0.979)
			P04	-8.3	-4.6% (-18.1%, 8.9%)	25.2	0.953 (0.937, 0.966)
			P05	3.1	2.3% (-15.8%, 20.4%)	29.8	0.956 (0.928, 0.973)
			P06	7.6	4.2% (-18.1%, 26.6%)	39.1	0.921 (0.873, 0.952)
			P07	6.8	4.1% (-10.9%, 19%)	24.5	0.967 (0.945, 0.98)
			P08	0.0	0.5% (-16.5%, 17.4%)	26.4	0.964 (0.95, 0.974)
			P09	4.8	2.4% (-24.1%, 28.8%)	49.0	0.888 (0.817, 0.932)
			P10	-0.9	0.2% (-18.9%, 19.3%)	35.3	0.947 (0.91, 0.968)
		P03	P04	-3.9	-2.1% (-22.1%, 17.9%)	28.6	0.96 (0.935, 0.975)
			P05	6.2	3.8% (-19.5%, 27.1%)	32.8	0.944 (0.911, 0.965)
			P06	9.4	5% (-16%, 26%)	38.6	0.926 (0.882, 0.954)
			P07	9.7	5.3% (-16.8%, 27.4%)	31.3	0.943 (0.909, 0.964)
			P08	4.3	2.8% (-16.6%, 22.2%)	33.2	0.951 (0.921, 0.97)
			P09	7.7	4% (-26.8%, 34.8%)	49.6	0.888 (0.818, 0.932)
			P10	4.8	2.9% (-24.5%, 30.4%)	41.9	0.926 (0.877, 0.956)
		P04	P05	10.4	6.1% (-11.3%, 23.5%)	32.5	0.932 (0.892, 0.957)
			P06	12.8	6.9% (-16.2%, 30%)	39.7	0.9 (0.843, 0.937)
			P07	13.4	7.3% (-11.6%, 26.2%)	35.9	0.908 (0.856, 0.942)
			P08	8.6	5.2% (-10.8%, 21.2%)	25.7	0.953 (0.935, 0.965)
			P09	9.7	5.4% (-22.3%, 33.1%)	49.6	0.873 (0.793, 0.923)
			P10	6.8	4.3% (-18.2%, 26.9%)	42.2	0.913 (0.853, 0.949)
		P05	P06	5.2	2% (-25.6%, 29.7%)	46.0	0.905 (0.851, 0.94)
			P07	3.7	1.6% (-14.7%, 17.9%)	27.9	0.963 (0.939, 0.977)
			P08	-1.9	-1% (-21.6%, 19.7%)	32.2	0.951 (0.92, 0.97)
			P09	-0.2	-0.7% (-25.8%, 24.4%)	42.8	0.922 (0.87, 0.953)
			P10	-2.6	-1.6% (-26.9%, 23.6%)	45.2	0.915 (0.857, 0.949)
		P06	P07	1.9	1% (-22.6%, 24.6%)	39.9	0.935 (0.895, 0.96)
			P08	-5.0	-2.2% (-24.4%, 20.1%)	39.9	0.926 (0.88, 0.955)
			P09	-3.2	-2% (-33.3%, 29.4%)	52.2	0.894 (0.822, 0.937)
			P10	-6.4	-3% (-30.6%, 24.6%)	47.4	0.91 (0.851, 0.947)
		P07	P08	-6.5	-3% (-25.6%, 19.6%)	34.1	0.94 (0.903, 0.963)
			P09	-3.0	-1.9% (-28.2%, 24.3%)	48.1	0.914 (0.855, 0.95)
			P10	-7.5	-3.6% (-26.7%, 19.4%)	42.5	0.925 (0.874, 0.955)
		P08	P09	2.0	0.4% (-26.3%, 27%)	46.2	0.905 (0.843, 0.944)
			P10	-0.1	-0.4% (-26.9%, 26.1%)	43.5	0.92 (0.866, 0.953)
		P09	P10	-2.3	-0.8% (-24%, 22.4%)	41.2	0.931 (0.886, 0.959)
	Right	P01	P02	7.6	4.7% (-6.5%, 15.9%)	17.9	0.973 (0.962, 0.981)
			P03	4.4	2.7% (-11.4%, 16.7%)	20.0	0.978 (0.962, 0.987)
			P04	1.8	1% (-11.3%, 13.3%)	21.6	0.974 (0.963, 0.982)
			P05	12.5	7.6% (-2.4%, 17.7%)	18.3	0.956 (0.93, 0.973)
			P06	11.7	7% (-8.6%, 22.6%)	28.7	0.941 (0.9, 0.965)
			P07	13.3	8% (-5.2%, 21.3%)	26.2	0.939 (0.9, 0.964)
			P08	9.2	5.4% (-5.6%, 16.4%)	19.4	0.964 (0.949, 0.974)
			P09	8.1	6% (-9.4%, 21.5%)	21.5	0.968 (0.943, 0.982)
			P10	8.2	5.6% (-14.1%, 25.4%)	30.0	0.954 (0.918, 0.974)
		P02	P03	-2.2	-1.5% (-20.7%, 17.6%)	26.2	0.971 (0.951, 0.983)
			P04	-5.4	-3.6% (-17%, 9.8%)	21.0	0.974 (0.963, 0.982)
			P05	6.4	3.5% (-9.4%, 16.3%)	22.7	0.973 (0.955, 0.984)
			P06	7.3	3.5% (-12.1%, 19.2%)	30.5	0.956 (0.926, 0.974)
			P07	7.9	4.2% (-11.3%, 19.6%)	30.2	0.956 (0.926, 0.974)
			P08	2.1	0.8% (-11.3%, 13%)	21.3	0.979 (0.97, 0.985)
			P09	2.5	1.9% (-16.9%, 20.7%)	34.1	0.954 (0.918, 0.975)
			P10	2.1	1.4% (-17.8%, 20.5%)	32.1	0.958 (0.925, 0.977)
		P03	P04	-2.0	-1.2% (-16.2%, 13.9%)	24.8	0.974 (0.956, 0.985)
			P05	8.3	4.9% (-9.7%, 19.5%)	23.8	0.965 (0.942, 0.979)
			P06	8.4	4.6% (-16.1%, 25.3%)	35.0	0.94 (0.898, 0.965)
			P07	9.3	5.4% (-13.8%, 24.6%)	31.6	0.947 (0.91, 0.969)
			P08	7.3	4.2% (-13.7%, 22.1%)	26.4	0.96 (0.932, 0.976)
			P09	4.5	3.5% (-16.4%, 23.3%)	30.4	0.961 (0.93, 0.978)
			P10	4.3	3.1% (-24.5%, 30.6%)	37.6	0.94 (0.894, 0.967)
		P04	P05	10.6	6.2% (-6%, 18.3%)	23.4	0.961 (0.937, 0.976)
			P06	11.2	6.2% (-7.7%, 20.1%)	27.3	0.953 (0.923, 0.972)
			P07	12.3	7% (-9.8%, 23.8%)	32.6	0.938 (0.897, 0.962)
			P08	7.6	4.5% (-7.1%, 16%)	19.9	0.969 (0.957, 0.978)
			P09	5.2	4.1% (-14.9%, 23%)	32.1	0.959 (0.927, 0.977)
			P10	5.3	3.8% (-16.8%, 24.4%)	30.5	0.961 (0.931, 0.978)
		P05	P06	0.5	-0.2% (-15.9%, 15.6%)	30.9	0.963 (0.937, 0.978)
			P07	1.4	0.6% (-14.8%, 15.9%)	29.2	0.967 (0.943, 0.981)
			P08	-1.2	-0.9% (-12.5%, 10.7%)	20.6	0.98 (0.966, 0.988)
			P09	-4.6	-2% (-18.9%, 14.9%)	27.6	0.969 (0.945, 0.982)
			P10	-4.5	-2.3% (-22.9%, 18.3%)	30.3	0.962 (0.932, 0.978)
		P06	P07	0.9	0.7% (-19.1%, 20.6%)	37.3	0.943 (0.903, 0.967)
			P08	-1.0	-0.7% (-14.6%, 13.3%)	26.4	0.969 (0.947, 0.983)
			P09	-3.7	-1.1% (-21.1%, 19%)	38.2	0.946 (0.905, 0.97)
			P10	-5.9	-2.8% (-25.1%, 19.5%)	39.9	0.938 (0.889, 0.966)
		P07	P08	-2.7	-1.7% (-18.1%, 14.8%)	31.1	0.956 (0.923, 0.975)
			P09	-4.8	-2% (-18.7%, 14.7%)	33.8	0.957 (0.923, 0.976)
			P10	-8.3	-4.2% (-25.4%, 17%)	36.2	0.941 (0.898, 0.967)
		P08	P09	-3.5	-1.1% (-21%, 18.8%)	32.2	0.951 (0.914, 0.973)
			P10	-3.5	-1.4% (-20%, 17.1%)	29.4	0.962 (0.933, 0.979)
		P09	P10	0.4	-0.2% (-23.3%, 22.9%)	36.1	0.948 (0.906, 0.971)
3.0T	Left	P01	P02	11.5	4.1% (-9.9%, 18.1%)	39.5	0.939 (0.911, 0.958)
			P03	5.8	1.7% (-15.7%, 19.1%)	50.1	0.929 (0.876, 0.96)
			P04	1.3	0.2% (-15.6%, 16.1%)	47.3	0.931 (0.9, 0.953)
			P05	19.4	7.7% (-17.6%, 32.9%)	73.3	0.839 (0.737, 0.904)
			P06	18.9	7% (-13.1%, 27.2%)	55.5	0.896 (0.822, 0.94)
			P07	19.8	7.8% (-11.6%, 27.2%)	54.5	0.896 (0.824, 0.94)
			P08	17.9	6.2% (-16.3%, 28.8%)	60.5	0.851 (0.791, 0.895)
			P09	5.5	2% (-20.8%, 24.8%)	63.9	0.9 (0.819, 0.946)
			P10	7.7	4.1% (-24.1%, 32.3%)	74.7	0.872 (0.779, 0.927)
		P02	P03	-6.7	-2.7% (-18.9%, 13.5%)	44.8	0.941 (0.899, 0.966)
			P04	-9.7	-3.7% (-20.5%, 13.1%)	47.8	0.92 (0.885, 0.944)
			P05	3.2	1.7% (-20.6%, 23.9%)	62.4	0.908 (0.846, 0.945)
			P06	5.3	1.8% (-19%, 22.7%)	57.3	0.923 (0.867, 0.956)
			P07	6.7	2.7% (-15.1%, 20.6%)	52.2	0.931 (0.879, 0.961)
			P08	6.1	2% (-22.2%, 26.2%)	64.8	0.873 (0.821, 0.911)
			P09	-7.1	-3% (-29.6%, 23.6%)	72.6	0.868 (0.765, 0.927)
			P10	-4.1	-0.7% (-23.2%, 21.8%)	60.6	0.917 (0.855, 0.953)
		P03	P04	-3.1	-0.7% (-21.7%, 20.3%)	58.2	0.908 (0.841, 0.947)
			P05	11.4	4.5% (-19%, 28%)	68.5	0.868 (0.78, 0.922)
			P06	12.0	4.5% (-18.5%, 27.5%)	64.5	0.886 (0.802, 0.936)
			P07	12.4	5% (-14.2%, 24.2%)	55.2	0.908 (0.837, 0.948)
			P08	18.5	6.9% (-21.2%, 35.1%)	71.0	0.824 (0.709, 0.897)
			P09	6.4	2.8% (-24.2%, 29.7%)	75.6	0.865 (0.753, 0.929)
			P10	-1.8	0% (-25.3%, 25.3%)	73.7	0.868 (0.762, 0.929)
		P04	P05	14.1	5.7% (-18.5%, 29.8%)	67.2	0.878 (0.799, 0.928)
			P06	13.3	4.9% (-17.4%, 27.2%)	58.3	0.905 (0.837, 0.945)
			P07	15.7	6.2% (-16.1%, 28.5%)	61.1	0.889 (0.812, 0.935)
			P08	16.1	5.8% (-16.2%, 27.9%)	58.2	0.863 (0.807, 0.903)
			P09	4.0	1.3% (-26.1%, 28.7%)	75.1	0.862 (0.755, 0.924)
			P10	6.0	3.2% (-26.7%, 33%)	80.9	0.853 (0.747, 0.917)
		P05	P06	0.6	-0.4% (-23.4%, 22.6%)	64.5	0.912 (0.85, 0.949)
			P07	0.4	0% (-25%, 25.1%)	74.1	0.877 (0.79, 0.93)
			P08	6.4	1.8% (-27%, 30.6%)	75.0	0.858 (0.766, 0.916)
			P09	-13.3	-5.7% (-40.8%, 29.4%)	97.2	0.775 (0.617, 0.873)
			P10	-8.6	-2.9% (-33.9%, 28%)	90.3	0.819 (0.688, 0.899)
		P06	P07	-0.3	0.5% (-23.3%, 24.2%)	65.1	0.906 (0.834, 0.948)
			P08	5.7	2.2% (-23.4%, 27.7%)	64.8	0.892 (0.813, 0.938)
			P09	-10.5	-4.3% (-36.6%, 28%)	83.7	0.821 (0.676, 0.905)
			P10	-9.4	-2.4% (-34.9%, 30%)	88.4	0.827 (0.697, 0.904)
		P07	P08	4.6	1.3% (-31.6%, 34.2%)	82.6	0.826 (0.709, 0.898)
			P09	-14.4	-6.1% (-32.5%, 20.3%)	69.1	0.869 (0.767, 0.928)
			P10	-11.3	-3.7% (-25.3%, 18%)	61.1	0.909 (0.84, 0.949)
		P08	P09	-14.2	-5.1% (-37.2%, 26.9%)	86.5	0.782 (0.629, 0.876)
			P10	-15.5	-4.7% (-46.4%, 37%)	106.8	0.715 (0.541, 0.831)
		P09	P10	8.1	3.8% (-29.1%, 36.7%)	80.8	0.843 (0.724, 0.914)
	Right	P01	P02	13.6	4.9% (-5.9%, 15.7%)	30.4	0.955 (0.933, 0.97)
			P03	7.4	2.3% (-15.2%, 19.8%)	52.3	0.929 (0.863, 0.963)
			P04	-1.9	-0.6% (-17.8%, 16.6%)	49.8	0.932 (0.897, 0.956)
			P05	18.5	6.7% (-8.4%, 21.8%)	43.7	0.937 (0.889, 0.965)
			P06	16.2	5.1% (-14.2%, 24.5%)	48.7	0.939 (0.888, 0.968)
			P07	17.8	6.8% (-12.9%, 26.5%)	56.3	0.919 (0.85, 0.957)
			P08	10.4	3.7% (-11.5%, 18.8%)	44.0	0.934 (0.9, 0.956)
			P09	0.4	1.1% (-25.2%, 27.4%)	67.8	0.92 (0.84, 0.961)
			P10	7.9	4% (-19.6%, 27.5%)	65.7	0.921 (0.846, 0.96)
		P02	P03	-6.4	-2.5% (-17.6%, 12.5%)	44.2	0.95 (0.906, 0.974)
			P04	-15.6	-5.5% (-20.1%, 9%)	41.6	0.929 (0.895, 0.952)
			P05	5.8	2% (-13.9%, 17.9%)	40.8	0.964 (0.933, 0.981)
			P06	4.3	0.7% (-18.9%, 20.2%)	48.7	0.955 (0.916, 0.976)
			P07	4.8	1.9% (-20.5%, 24.2%)	60.3	0.931 (0.871, 0.963)
			P08	-2.5	-1.1% (-17%, 14.8%)	43.3	0.946 (0.919, 0.964)
			P09	-12.0	-3.9% (-27.2%, 19.5%)	56.6	0.934 (0.869, 0.967)
			P10	-5.0	-1% (-23.8%, 21.8%)	60.4	0.933 (0.87, 0.966)
		P03	P04	-9.5	-2.6% (-16.5%, 11.2%)	43.6	0.949 (0.905, 0.973)
			P05	12.4	4.3% (-13.9%, 22.4%)	53.3	0.911 (0.835, 0.953)
			P06	9.0	2.8% (-11.3%, 16.8%)	40.9	0.954 (0.91, 0.977)
			P07	10.1	3.5% (-19.9%, 27%)	65.7	0.882 (0.777, 0.939)
			P08	11.4	3.9% (-12.1%, 19.9%)	47.4	0.931 (0.871, 0.964)
			P09	-4.6	0.1% (-26.2%, 26.4%)	68.1	0.902 (0.805, 0.952)
			P10	-5.3	-0.3% (-23.1%, 22.4%)	63.4	0.905 (0.816, 0.952)
		P04	P05	21.2	7.2% (-14.6%, 28.9%)	63.6	0.896 (0.821, 0.94)
			P06	12.6	3.8% (-11.1%, 18.7%)	40.5	0.96 (0.927, 0.978)
			P07	20.3	7.3% (-21.4%, 36.1%)	78.3	0.863 (0.756, 0.926)
			P08	12.5	4.3% (-10.3%, 18.8%)	43.0	0.935 (0.904, 0.957)
			P09	5.1	2.2% (-30.5%, 34.9%)	81.3	0.892 (0.786, 0.947)
			P10	7.9	3.8% (-25.3%, 32.8%)	80.4	0.889 (0.785, 0.944)
		P05	P06	-4.0	-2.1% (-22.5%, 18.2%)	52.9	0.945 (0.895, 0.971)
			P07	-1.2	-0.2% (-18.3%, 17.9%)	51.4	0.948 (0.902, 0.973)
			P08	-2.9	-1.1% (-16.9%, 14.8%)	45.7	0.957 (0.922, 0.977)
			P09	-16.2	-5.4% (-33.6%, 22.8%)	68.7	0.9 (0.809, 0.949)
			P10	-9.3	-2.7% (-24.9%, 19.6%)	63.5	0.922 (0.85, 0.96)
		P06	P07	1.2	1.5% (-23.7%, 26.7%)	59.4	0.934 (0.871, 0.967)
			P08	2.5	1.5% (-14.4%, 17.4%)	43.2	0.965 (0.934, 0.982)
			P09	-14.1	-3.5% (-39.5%, 32.5%)	78.2	0.882 (0.765, 0.942)
			P10	-10.7	-1.7% (-34.1%, 30.7%)	80.7	0.871 (0.755, 0.934)
		P07	P08	-0.9	-0.7% (-23%, 21.7%)	60.8	0.926 (0.862, 0.961)
			P09	-13.4	-4.9% (-34.5%, 24.7%)	70.7	0.897 (0.796, 0.95)
			P10	-7.0	-2.2% (-28%, 23.6%)	68.3	0.913 (0.83, 0.957)
		P08	P09	-16.7	-5.2% (-36.7%, 26.3%)	77.9	0.869 (0.751, 0.933)
			P10	-9.3	-2.3% (-29.4%, 24.7%)	73.7	0.896 (0.802, 0.946)
		P09	P10	7.7	3.2% (-20.4%, 26.9%)	53.9	0.944 (0.884, 0.974)

LIC (7,15]

This section looks into the repeatability and reproducibility for subjects with LIC \(\in\) (7,15].

Repeatability analysis

The number of pairs for test-retest repeatability analysis by protocol, field strength, and lobe is listed below.

Overall

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol and field strength across all segments/lobes below.

Test-retest repeatability analysis by protocol and field strength across all segments/lobes.

Protocol	Field	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	-5.5	-1.4% (-16.7%, 14%)	62.3	0.97 (0.957, 0.979)	< 0.001
P01	3.0T	-28.2	-3.9% (-27.1%, 19.3%)	194.0	0.919 (0.885, 0.943)	< 0.001
P02	1.5T	1.9	0.5% (-16%, 16.9%)	63.9	0.964 (0.949, 0.974)	< 0.001
P02	3.0T	5.6	1.1% (-11.5%, 13.7%)	88.3	0.978 (0.968, 0.984)	< 0.001
P04	1.5T	-2.7	-0.8% (-20.5%, 18.8%)	68.1	0.922 (0.889, 0.945)	< 0.001
P04	3.0T	-3.8	0% (-25.5%, 25.4%)	168.6	0.835 (0.767, 0.884)	< 0.001
P08	1.5T	4.4	1.2% (-20.3%, 22.7%)	81.4	0.934 (0.906, 0.955)	< 0.001
P08	3.0T	-6.9	-0.8% (-24.7%, 23.1%)	140.0	0.879 (0.828, 0.916)	< 0.001

By lobe

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol, field strength, and lobe below.

Test-retest repeatability analysis by protocol, field strength, and lobe.

Protocol	Field	Lobe	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	Left	-6.9	-2.1% (-19.8%, 15.5%)	68.7	0.958 (0.932, 0.974)	< 0.001
P01	1.5T	Right	-3.8	-0.5% (-12.3%, 11.3%)	53.6	0.981 (0.967, 0.989)	< 0.001
P01	3.0T	Left	-35.8	-4.6% (-31.2%, 21.9%)	223.3	0.871 (0.797, 0.919)	< 0.001
P01	3.0T	Right	-18.7	-2.9% (-21.1%, 15.3%)	149.6	0.961 (0.934, 0.978)	< 0.001
P02	1.5T	Left	-0.2	-0.1% (-18.6%, 18.4%)	67.2	0.954 (0.927, 0.971)	< 0.001
P02	1.5T	Right	4.6	1.2% (-12.5%, 14.8%)	59.7	0.973 (0.954, 0.984)	< 0.001
P02	3.0T	Left	7.4	1.6% (-13.1%, 16.3%)	103.4	0.959 (0.934, 0.975)	< 0.001
P02	3.0T	Right	3.3	0.5% (-8.8%, 9.8%)	65.5	0.991 (0.984, 0.995)	< 0.001
P04	1.5T	Left	-4.0	-1.4% (-24.2%, 21.3%)	78.6	0.877 (0.807, 0.923)	< 0.001
P04	1.5T	Right	-1.2	-0.1% (-15%, 14.9%)	52.5	0.961 (0.933, 0.977)	< 0.001
P04	3.0T	Left	-17.0	-1.9% (-32.9%, 29.2%)	205.7	0.663 (0.494, 0.784)	< 0.001
P04	3.0T	Right	12.8	2.3% (-12.8%, 17.3%)	98.4	0.954 (0.919, 0.974)	< 0.001
P08	1.5T	Left	6.9	1.3% (-23.4%, 26%)	92.2	0.904 (0.845, 0.941)	< 0.001
P08	1.5T	Right	1.4	1% (-16%, 17.9%)	65.9	0.964 (0.937, 0.98)	< 0.001
P08	3.0T	Left	-7.4	-0.3% (-28.4%, 27.8%)	162.4	0.77 (0.644, 0.856)	< 0.001
P08	3.0T	Right	-6.3	-1.5% (-18.9%, 15.9%)	107.5	0.945 (0.905, 0.969)	< 0.001

Reproducibility analysis

Overall

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized across all segments/lobes below.

Between-protocol reproducibility analysis across all segments/lobes for smaller values.

Field	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	P01	P02	9.2	4.1% (-9.4%, 17.7%)	32.3	0.9 (0.851, 0.933)
		P03	10.2	4.4% (-21.5%, 30.3%)	55.3	0.79 (0.646, 0.879)
		P04	4.3	2% (-10.2%, 14.1%)	28.9	0.935 (0.9, 0.957)
		P05	12.4	5.5% (-14.4%, 25.4%)	45.4	0.847 (0.75, 0.908)
		P06	16.7	7.7% (-9.9%, 25.2%)	37.3	0.864 (0.774, 0.919)
		P07	14.2	6.4% (-9.3%, 22.1%)	32.5	0.898 (0.833, 0.939)
		P08	17.1	7.6% (-13.3%, 28.6%)	46.2	0.788 (0.698, 0.854)
		P09	18.2	8.2% (-8.4%, 24.8%)	37.0	0.869 (0.769, 0.927)
		P10	21.9	11.5% (-7.8%, 30.7%)	35.7	0.847 (0.725, 0.917)
	P02	P03	-4.9	-2.5% (-30.2%, 25.2%)	54.6	0.822 (0.696, 0.899)
		P04	-4.0	-1.9% (-15.1%, 11.4%)	31.4	0.927 (0.892, 0.952)
		P05	3.9	1.4% (-22.3%, 25.1%)	52.4	0.846 (0.754, 0.906)
		P06	5.3	2.2% (-16.7%, 21.1%)	41.2	0.902 (0.835, 0.943)
		P07	5.3	2.1% (-19.4%, 23.6%)	46.8	0.873 (0.795, 0.923)
		P08	5.2	2.4% (-19.9%, 24.6%)	48.6	0.835 (0.762, 0.887)
		P09	8.2	3.2% (-19.1%, 25.5%)	46.6	0.882 (0.794, 0.934)
		P10	12.8	6.3% (-19.4%, 32%)	55.4	0.837 (0.704, 0.914)
	P03	P04	-4.1	-1.6% (-29.2%, 25.9%)	58.9	0.778 (0.631, 0.871)
		P05	4.6	2.1% (-24%, 28.1%)	56.6	0.799 (0.677, 0.879)
		P06	5.5	3% (-25.2%, 31.1%)	56.6	0.815 (0.691, 0.892)
		P07	5.7	2.7% (-21.2%, 26.6%)	53.9	0.82 (0.705, 0.892)
		P08	10.9	5.1% (-15.3%, 25.5%)	43.9	0.861 (0.771, 0.917)
		P09	8.5	4.3% (-24.1%, 32.6%)	60.9	0.804 (0.646, 0.896)
		P10	16.4	9% (-21.8%, 39.8%)	57.7	0.812 (0.658, 0.9)
	P04	P05	10.6	4.6% (-14.5%, 23.6%)	43.4	0.857 (0.771, 0.913)
		P06	10.1	4.6% (-11.2%, 20.4%)	33.7	0.913 (0.853, 0.949)
		P07	9.4	4.2% (-12.8%, 21.1%)	37.0	0.9 (0.836, 0.939)
		P08	11.4	5.1% (-18.1%, 28.3%)	52.7	0.786 (0.695, 0.852)
		P09	10.9	5% (-13.5%, 23.4%)	36.8	0.913 (0.836, 0.954)
		P10	20.8	10.3% (-11.4%, 32%)	48.1	0.83 (0.692, 0.91)
	P05	P06	3.1	1.6% (-25%, 28.2%)	59.7	0.79 (0.669, 0.87)
		P07	0.9	0.3% (-20%, 20.7%)	46.0	0.875 (0.803, 0.921)
		P08	7.3	3.3% (-24.2%, 30.8%)	62.0	0.752 (0.625, 0.84)
		P09	1.7	0.7% (-23.2%, 24.5%)	53.9	0.858 (0.758, 0.919)
		P10	9.0	5% (-15.8%, 25.9%)	42.8	0.903 (0.822, 0.948)
	P06	P07	0.8	0.1% (-19%, 19.2%)	39.2	0.914 (0.858, 0.949)
		P08	0.3	0.1% (-23.3%, 23.5%)	51.4	0.852 (0.764, 0.909)
		P09	-1.3	-0.8% (-26.2%, 24.6%)	54.2	0.866 (0.765, 0.926)
		P10	7.1	3.8% (-19.7%, 27.3%)	46.9	0.903 (0.817, 0.95)
	P07	P08	7.1	3.2% (-20.8%, 27.1%)	55.2	0.814 (0.71, 0.883)
		P09	-0.3	0% (-18.9%, 18.9%)	43.6	0.907 (0.839, 0.948)
		P10	7.9	4.2% (-19.9%, 28.3%)	48.9	0.891 (0.802, 0.942)
	P08	P09	-6.5	-3% (-31.2%, 25.2%)	61.2	0.808 (0.674, 0.891)
		P10	3.7	2.2% (-27.9%, 32.2%)	61.1	0.839 (0.709, 0.914)
	P09	P10	7.9	4.2% (-19.9%, 28.2%)	51.5	0.881 (0.783, 0.936)
3.0T	P01	P02	15.3	4.8% (-13.5%, 23.2%)	60.3	0.509 (0.228, 0.712)
		P03	5.3	1.7% (-27.1%, 30.6%)	91.5	-0.106 (-0.522, 0.349)
		P04	-2.0	-0.5% (-18%, 17%)	60.0	0.403 (0.015, 0.685)
		P05	30.2	9.7% (-28.8%, 48.3%)	113.2	-0.201 (-0.503, 0.146)
		P06	29.3	8.9% (-2.3%, 20.1%)	37.3	0.472 (0.2, 0.677)
		P07	28.0	8.6% (-8.9%, 26.1%)	55.7	0.341 (0.02, 0.598)
		P08	17.2	5.1% (-7.9%, 18.1%)	44.7	0.58 (0.319, 0.759)
		P09	14.6	4.2% (-16.3%, 24.6%)	67.5	-0.051 (-0.428, 0.34)
		P10	6.7	2.6% (-19.5%, 24.6%)	74.6	0.495 (0.079, 0.764)
	P02	P03	-22.5	-6.8% (-30.8%, 17.1%)	69.6	0.332 (-0.05, 0.63)
		P04	-18.2	-5.6% (-23%, 11.8%)	57.1	0.576 (0.299, 0.764)
		P05	1.4	0.9% (-34.7%, 36.6%)	97.4	0.131 (-0.339, 0.549)
		P06	14.1	4.9% (-36.4%, 46.3%)	115.3	-0.051 (-0.451, 0.366)
		P07	0.2	0% (-19.6%, 19.6%)	58.5	0.516 (0.082, 0.786)
		P08	2.0	0.3% (-15.6%, 16.2%)	51.4	0.706 (0.468, 0.849)
		P09	-18.7	-6.6% (-32.5%, 19.3%)	80.1	-0.145 (-0.46, 0.202)
		P10	-15.6	-4.6% (-25.1%, 15.9%)	69.9	0.59 (0.191, 0.822)
	P03	P04	-2.8	-1% (-28.7%, 26.7%)	87.1	0.043 (-0.413, 0.482)
		P05	15.8	5% (-21.8%, 31.8%)	76.6	0.541 (0.144, 0.788)
		P06	24.0	7.2% (-21%, 35.3%)	85.2	0.01 (-0.337, 0.355)
		P07	16.4	4.6% (-29.7%, 38.9%)	100.8	-0.007 (-0.385, 0.374)
		P08	16.1	4.6% (-17.3%, 26.4%)	64.9	0.304 (-0.072, 0.604)
		P09	20.0	5.9% (-12.3%, 24.2%)	61.6	-0.194 (-0.524, 0.188)
		P10	8.2	3.1% (-20.6%, 26.9%)	78.4	0.368 (-0.006, 0.652)
	P04	P05	23.8	7.9% (-29.7%, 45.5%)	108.6	-0.146 (-0.483, 0.229)
		P06	24.7	6.4% (-14.5%, 27.4%)	53.8	0.863 (0.712, 0.938)
		P07	8.6	-0.7% (-74.8%, 73.5%)	153.5	0.025 (-0.29, 0.335)
		P08	20.3	5.9% (-8.8%, 20.7%)	49.8	0.532 (0.244, 0.734)
		P09	15.0	4.1% (-16.6%, 24.8%)	69.1	0.163 (-0.195, 0.483)
		P10	7.3	2.6% (-27.4%, 32.7%)	98.8	0.185 (-0.304, 0.597)
	P05	P06	0.1	-0.5% (-39.3%, 38.3%)	109.1	-0.198 (-0.58, 0.254)
		P07	-0.7	-0.7% (-39.9%, 38.5%)	110.7	-0.217 (-0.592, 0.236)
		P08	-6.8	-2.9% (-35.6%, 29.8%)	89.0	0.116 (-0.287, 0.485)
		P09	13.8	3.9% (-16.9%, 24.8%)	69.0	-0.134 (-0.537, 0.319)
		P10	-12.3	-3.1% (-33.1%, 27%)	100.3	0.046 (-0.383, 0.46)
	P06	P07	-12.5	-5.7% (-75.8%, 64.4%)	163.7	-0.14 (-0.49, 0.249)
		P08	-7.8	-2.6% (-15%, 9.8%)	40.4	0.623 (0.267, 0.829)
		P09	-3.8	-2.4% (-42.5%, 37.7%)	104.3	0.578 (0.016, 0.863)
		P10	-34.5	-11.2% (-51.8%, 29.3%)	111.7	0.149 (-0.233, 0.491)
	P07	P08	-6.5	-2.3% (-16.4%, 11.9%)	43.3	0.627 (0.282, 0.829)
		P09	-21.2	-7.2% (-20.8%, 6.3%)	37.8	0.337 (0.001, 0.604)
		P10	-16.1	-4.7% (-34.5%, 25.1%)	96.4	0.247 (-0.215, 0.619)
	P08	P09	-7.3	-2.6% (-18.8%, 13.6%)	50.6	0.165 (-0.339, 0.596)
		P10	-13.7	-3.5% (-24.7%, 17.6%)	70.4	0.48 (0.134, 0.722)
	P09	P10	14.8	5.1% (-17.9%, 28.1%)	68.9	-0.257 (-0.604, 0.173)

By lobe

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized by lobe below.

Between-protocol reproducibility analysis of R2* by lobe for smaller values.

Field	Lobe	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	Left	P01	P02	8.4	3.8% (-12.3%, 19.9%)	39.6	0.851 (0.749, 0.913)
			P03	6.8	2.8% (-17.6%, 23.1%)	44.7	0.849 (0.678, 0.933)
			P04	6.3	2.6% (-11.7%, 17%)	34.2	0.892 (0.811, 0.939)
			P05	10.3	4.8% (-17.7%, 27.2%)	51.5	0.804 (0.618, 0.905)
			P06	21.2	9.9% (-10.8%, 30.7%)	45.5	0.773 (0.573, 0.886)
			P07	14.1	6.5% (-8.7%, 21.7%)	34.9	0.876 (0.752, 0.94)
			P08	15.5	7% (-12.8%, 26.7%)	43.5	0.81 (0.688, 0.887)
			P09	19.7	9.9% (-5.9%, 25.6%)	37.2	0.857 (0.684, 0.938)
			P10	21.5	12.3% (-12.5%, 37%)	43.1	0.814 (0.609, 0.917)
		P02	P03	-4.9	-2.7% (-28.7%, 23.4%)	55.6	0.793 (0.584, 0.903)
			P04	-1.5	-0.9% (-16.1%, 14.4%)	35.2	0.902 (0.835, 0.943)
			P05	6.4	2.5% (-25.1%, 30.2%)	63.6	0.76 (0.57, 0.873)
			P06	8.9	4% (-18.1%, 26.1%)	50.0	0.845 (0.701, 0.923)
			P07	6.3	2.5% (-19.4%, 24.4%)	51.9	0.836 (0.693, 0.915)
			P08	5.4	2.4% (-20.8%, 25.6%)	51.8	0.811 (0.699, 0.884)
			P09	13.4	6% (-13.9%, 25.9%)	46.5	0.868 (0.728, 0.939)
			P10	19.1	9.4% (-18.6%, 37.5%)	59.9	0.791 (0.566, 0.907)
		P03	P04	-0.9	-0.1% (-22.4%, 22.2%)	46.5	0.84 (0.662, 0.928)
			P05	6.1	2.9% (-21.9%, 27.7%)	52.0	0.802 (0.62, 0.903)
			P06	8.6	4.9% (-24.1%, 33.8%)	58.0	0.789 (0.588, 0.898)
			P07	9.5	4.5% (-16.9%, 25.8%)	45.5	0.839 (0.683, 0.922)
			P08	8.5	4.2% (-17.1%, 25.5%)	44.2	0.856 (0.714, 0.93)
			P09	10.0	6% (-21.4%, 33.3%)	61.6	0.799 (0.579, 0.91)
			P10	20.2	11.4% (-24%, 46.7%)	68.0	0.7 (0.4, 0.864)
		P04	P05	10.7	4.8% (-14.6%, 24.2%)	42.7	0.841 (0.696, 0.92)
			P06	13.0	6.2% (-9.9%, 22.4%)	31.6	0.901 (0.802, 0.952)
			P07	9.7	4.4% (-11.1%, 20%)	35.6	0.888 (0.778, 0.945)
			P08	7.1	3.4% (-18%, 24.9%)	46.9	0.831 (0.723, 0.899)
			P09	10.1	5.8% (-13.6%, 25.2%)	39.0	0.905 (0.782, 0.96)
			P10	27.2	14% (-10.4%, 38.4%)	51.9	0.719 (0.423, 0.876)
		P05	P06	8.6	4.1% (-27%, 35.2%)	70.4	0.681 (0.446, 0.828)
			P07	1.4	0.5% (-23.1%, 24.1%)	52.4	0.829 (0.685, 0.91)
			P08	5.5	2.4% (-27.4%, 32.3%)	67.4	0.699 (0.49, 0.832)
			P09	1.0	0.9% (-26.8%, 28.7%)	63.7	0.808 (0.615, 0.91)
			P10	13.8	7.7% (-16.9%, 32.3%)	50.4	0.843 (0.659, 0.932)
		P06	P07	-2.3	-1.5% (-22.3%, 19.3%)	43.8	0.892 (0.783, 0.948)
			P08	-4.0	-2.1% (-24.9%, 20.8%)	51.3	0.843 (0.711, 0.918)
			P09	-3.5	-1.4% (-28.9%, 26%)	60.8	0.839 (0.674, 0.924)
			P10	10.6	5.3% (-22.2%, 32.9%)	54.8	0.869 (0.704, 0.945)
		P07	P08	4.0	1.8% (-20.6%, 24.3%)	50.4	0.839 (0.7, 0.917)
			P09	1.4	1.4% (-15.7%, 18.4%)	40.4	0.921 (0.83, 0.964)
			P10	11.0	6% (-20.1%, 32.2%)	52.2	0.865 (0.707, 0.941)
		P08	P09	-3.6	-1% (-27.7%, 25.6%)	60.3	0.826 (0.644, 0.919)
			P10	8.5	4.8% (-27%, 36.5%)	61.5	0.819 (0.604, 0.922)
		P09	P10	8.5	4.2% (-22%, 30.4%)	56.4	0.87 (0.716, 0.943)
	Right	P01	P02	10.2	4.6% (-4.9%, 14.2%)	20.0	0.948 (0.907, 0.971)
			P03	14.1	6.3% (-24.8%, 37.3%)	65.5	0.741 (0.468, 0.885)
			P04	2.0	1.2% (-7.9%, 10.2%)	20.6	0.972 (0.948, 0.985)
			P05	14.7	6.4% (-10.6%, 23.3%)	38.2	0.881 (0.758, 0.944)
			P06	11.8	5.2% (-6.7%, 17.1%)	23.1	0.945 (0.878, 0.975)
			P07	14.3	6.4% (-10.1%, 22.8%)	30.6	0.913 (0.822, 0.959)
			P08	19.1	8.4% (-14%, 30.9%)	49.5	0.764 (0.608, 0.864)
			P09	16.6	6.6% (-10.7%, 23.8%)	37.6	0.876 (0.735, 0.944)
			P10	22.3	10.5% (-0.1%, 21.2%)	26.6	0.879 (0.719, 0.951)
		P02	P03	-4.9	-2.3% (-32.7%, 28%)	54.8	0.85 (0.653, 0.939)
			P04	-7.2	-3.1% (-12.9%, 6.8%)	24.8	0.951 (0.911, 0.974)
			P05	0.5	-0.1% (-17.4%, 17.3%)	32.7	0.947 (0.884, 0.976)
			P06	0.4	-0.3% (-12.5%, 12%)	22.1	0.975 (0.944, 0.989)
			P07	4.0	1.5% (-19.9%, 22.8%)	40.4	0.915 (0.819, 0.961)
			P08	5.0	2.3% (-18.7%, 23.2%)	44.2	0.867 (0.759, 0.929)
			P09	0.9	-0.7% (-24.5%, 23.2%)	44.2	0.905 (0.778, 0.961)
			P10	3.9	1.8% (-17.9%, 21.5%)	44.6	0.909 (0.743, 0.97)
		P03	P04	-7.5	-3.3% (-35.6%, 29.1%)	70.0	0.731 (0.46, 0.877)
			P05	3.0	1.2% (-26.6%, 29%)	62.3	0.795 (0.591, 0.904)
			P06	2.2	0.9% (-26.5%, 28.3%)	55.6	0.839 (0.653, 0.929)
			P07	1.5	0.8% (-25.7%, 27.2%)	62.0	0.803 (0.597, 0.909)
			P08	13.5	6.1% (-13.5%, 25.7%)	43.9	0.865 (0.724, 0.937)
			P09	6.5	2.1% (-27.9%, 32.1%)	62.0	0.811 (0.549, 0.927)
			P10	11.4	5.8% (-17.8%, 29.5%)	41.1	0.921 (0.774, 0.974)
		P04	P05	10.6	4.4% (-14.7%, 23.4%)	44.9	0.867 (0.733, 0.937)
			P06	6.9	2.8% (-12.2%, 17.8%)	35.6	0.922 (0.83, 0.966)
			P07	9.2	3.9% (-14.7%, 22.5%)	39.1	0.904 (0.804, 0.954)
			P08	16.8	7.3% (-17.7%, 32.2%)	58.0	0.74 (0.574, 0.848)
			P09	11.6	4.1% (-13.8%, 22%)	35.6	0.916 (0.823, 0.961)
			P10	14.4	6.6% (-9.9%, 23%)	41.9	0.904 (0.753, 0.965)
		P05	P06	-3.6	-1.5% (-20.2%, 17.2%)	40.8	0.907 (0.805, 0.957)
			P07	0.2	0.2% (-16.3%, 16.6%)	38.9	0.915 (0.834, 0.958)
			P08	9.7	4.5% (-20%, 29%)	55.1	0.812 (0.64, 0.907)
			P09	2.4	0.3% (-18.7%, 19.2%)	40.8	0.918 (0.82, 0.964)
			P10	3.4	1.9% (-11.7%, 15.5%)	29.4	0.964 (0.902, 0.987)
		P06	P07	4.0	1.8% (-15.2%, 18.7%)	33.4	0.935 (0.864, 0.97)
			P08	5.9	2.9% (-20.5%, 26.3%)	50.4	0.862 (0.72, 0.935)
			P09	2.2	0.3% (-22.1%, 22.6%)	42.2	0.915 (0.785, 0.968)
			P10	2.0	1.6% (-14.4%, 17.6%)	31.9	0.958 (0.884, 0.985)
		P07	P08	10.6	4.7% (-21%, 30.3%)	60.2	0.79 (0.605, 0.894)
			P09	-2.0	-1.4% (-22%, 19.2%)	47.3	0.891 (0.765, 0.951)
			P10	3.7	1.8% (-19.2%, 22.8%)	44.7	0.923 (0.795, 0.972)
		P08	P09	-10.1	-5.5% (-35.5%, 24.5%)	63.3	0.785 (0.541, 0.907)
			P10	-2.3	-1.1% (-28.5%, 26.3%)	60.4	0.862 (0.652, 0.949)
		P09	P10	6.9	4.1% (-17.3%, 25.5%)	45.2	0.9 (0.742, 0.963)
3.0T	Left	P01	P02	17.7	5.7% (-11.3%, 22.7%)	55.8	0.611 (0.269, 0.817)
			P03	9.1	3.1% (-30.7%, 36.9%)	104.3	0.032 (-0.534, 0.578)
			P04	-0.3	-0.2% (-15.9%, 15.5%)	55.4	0.449 (-0.1, 0.789)
			P05	41.5	13.7% (-32.9%, 60.3%)	131.0	-0.075 (-0.47, 0.344)
			P06	26.3	8% (-4.1%, 20.2%)	39.9	0.572 (0.15, 0.817)
			P07	25.3	7.4% (-7.8%, 22.7%)	51.5	0.344 (-0.089, 0.667)
			P08	19.7	5.8% (-4.9%, 16.5%)	37.3	0.632 (0.298, 0.828)
			P09	7.0	1.6% (-23.6%, 26.9%)	83.0	-0.196 (-0.608, 0.298)
			P10	13.8	4.9% (-17%, 26.7%)	74.4	0.566 (0.006, 0.856)
		P02	P03	-20.8	-6.1% (-36.1%, 23.8%)	84.8	0.387 (-0.19, 0.766)
			P04	-20.4	-6.5% (-25.7%, 12.6%)	62.8	0.49 (0.112, 0.744)
			P05	9.5	3.9% (-41.4%, 49.3%)	119.1	0.188 (-0.458, 0.704)
			P06	18.8	6.8% (-46.9%, 60.5%)	149.1	-0.097 (-0.591, 0.45)
			P07	-4.6	-1.9% (-18.9%, 15.1%)	52.6	0.606 (0.154, 0.848)
			P08	2.8	0.3% (-17.5%, 18.1%)	57.3	0.595 (0.267, 0.799)
			P09	-25.5	-9.1% (-42.4%, 24.1%)	104.2	-0.136 (-0.441, 0.198)
			P10	-7.1	-2.2% (-23.8%, 19.5%)	75.8	0.672 (0.081, 0.913)
		P03	P04	-8.0	-3% (-32.4%, 26.5%)	89.5	0.188 (-0.359, 0.638)
			P05	14.8	4.8% (-30.9%, 40.5%)	101.2	0.533 (-0.072, 0.852)
			P06	17.2	4.9% (-29.9%, 39.7%)	104.1	0.064 (-0.486, 0.578)
			P07	5.9	0.7% (-37.4%, 38.7%)	111.6	0.027 (-0.387, 0.432)
			P08	12.8	3.2% (-22.8%, 29.2%)	75.1	0.378 (-0.095, 0.712)
			P09	14.9	4.2% (-16.3%, 24.7%)	70.5	-0.248 (-0.664, 0.286)
			P10	20.6	7% (-15.6%, 29.5%)	73.0	0.507 (0.035, 0.794)
		P04	P05	33.1	11.6% (-31.4%, 54.6%)	117.2	-0.031 (-0.367, 0.313)
			P06	21.8	5% (-19.2%, 29.1%)	55.9	0.918 (0.754, 0.975)
			P07	-4.9	-7.3% (-103.2%, 88.6%)	195.0	-0.083 (-0.353, 0.199)
			P08	24.5	7.2% (-3.4%, 17.8%)	36.7	0.436 (0.072, 0.697)
			P09	14.2	3.9% (-16.9%, 24.8%)	71.1	-0.091 (-0.538, 0.395)
			P10	17.4	6% (-21.6%, 33.6%)	91.9	0.319 (-0.26, 0.729)
		P05	P06	-13.5	-5.3% (-53.7%, 43.2%)	132.3	-0.081 (-0.614, 0.503)
			P07	-12.2	-5.1% (-47.8%, 37.6%)	115.7	-0.067 (-0.478, 0.368)
			P08	-15.8	-6.4% (-46%, 33.2%)	102.2	0.218 (-0.253, 0.605)
			P09	7.8	1.9% (-22%, 25.9%)	80.9	-0.078 (-0.66, 0.563)
			P10	-4.4	-0.5% (-32.7%, 31.7%)	107.6	0.169 (-0.492, 0.707)
		P06	P07	-33.9	-14.8% (-93.7%, 64.1%)	167.0	0.017 (-0.318, 0.348)
			P08	-4.4	-1.6% (-15.4%, 12.2%)	45.0	0.65 (0.173, 0.88)
			P09	-0.2	-1.9% (-53.4%, 49.7%)	133.6	0.568 (-0.216, 0.906)
			P10	-33.8	-11.8% (-62.5%, 38.8%)	135.1	0.12 (-0.408, 0.587)
		P07	P08	-3.4	-1% (-15%, 12.9%)	44.8	0.457 (-0.189, 0.827)
			P09	-17.1	-5.5% (-17.7%, 6.6%)	37.6	0.106 (-0.39, 0.554)
			P10	2.5	1.3% (-27%, 29.6%)	96.0	0.325 (-0.341, 0.774)
		P08	P09	-5.0	-1.9% (-24.3%, 20.4%)	69.8	-0.145 (-0.638, 0.432)
			P10	-3.3	-0.2% (-24.5%, 24.2%)	82.3	0.451 (-0.081, 0.783)
		P09	P10	30.7	10.3% (-11.6%, 32.2%)	63.3	-0.026 (-0.322, 0.274)
	Right	P01	P02	12.4	3.9% (-16.5%, 24.3%)	67.2	0.335 (-0.19, 0.711)
			P03	0.5	0% (-23%, 23%)	78.4	-0.625 (-0.897, -0.009)
			P04	-4.0	-0.8% (-21.1%, 19.4%)	67.5	0.355 (-0.208, 0.741)
			P05	17.6	5.2% (-22.1%, 32.6%)	91.3	-0.652 (-0.959, 0.364)
			P06	33.0	10.1% (-0.1%, 20.2%)	35.0	0.3 (-0.044, 0.581)
			P07	31.4	10.1% (-10.7%, 30.8%)	63.5	0.328 (-0.153, 0.683)
			P08	14.0	4.3% (-11.5%, 20.1%)	53.7	0.508 (0.027, 0.798)
			P09	24.2	7.3% (-6%, 20.6%)	46.1	0.168 (-0.272, 0.551)
			P10	-1.4	-0.1% (-22.9%, 22.8%)	77.3	0.352 (-0.412, 0.826)
		P02	P03	-24.7	-7.6% (-22.8%, 7.6%)	49.6	0.16 (-0.273, 0.539)
			P04	-15.8	-4.6% (-20.5%, 11.4%)	52.4	0.667 (0.233, 0.879)
			P05	-7.7	-2.4% (-24.1%, 19.2%)	69.0	-0.137 (-0.712, 0.549)
			P06	7.7	2.4% (-12.7%, 17.5%)	45.6	0.369 (-0.319, 0.802)
			P07	6.1	2.4% (-20.4%, 25.2%)	67.0	0.413 (-0.244, 0.81)
			P08	1.3	0.3% (-14.1%, 14.8%)	47.1	0.78 (0.426, 0.927)
			P09	-10.2	-3.5% (-18.4%, 11.5%)	44.1	-0.202 (-0.79, 0.579)
			P10	-26.5	-7.7% (-26.3%, 10.9%)	60.0	0.437 (-0.116, 0.783)
		P03	P04	3.7	1.5% (-25%, 28%)	88.3	-0.229 (-0.695, 0.372)
			P05	17.0	5.2% (-4.9%, 15.3%)	33.0	0.478 (-0.048, 0.797)
			P06	32.4	10% (-7.3%, 27.3%)	56.0	-0.083 (-0.359, 0.206)
			P07	30.8	10% (-17.1%, 37.1%)	82.3	0.006 (-0.362, 0.373)
			P08	20.3	6.3% (-10.2%, 22.7%)	53.3	0.129 (-0.364, 0.565)
			P09	26.2	8% (-9%, 25%)	55.9	-0.197 (-0.602, 0.288)
			P10	-5.9	-1.2% (-25%, 22.6%)	80.5	0.117 (-0.445, 0.612)
		P04	P05	13.3	3.7% (-27.4%, 34.8%)	101.7	-0.418 (-0.81, 0.231)
			P06	28.7	8.5% (-7.6%, 24.6%)	53.4	0.351 (-0.046, 0.652)
			P07	27.1	8.5% (-10.1%, 27.1%)	60.8	0.501 (-0.073, 0.826)
			P08	16.0	4.6% (-13.5%, 22.8%)	60.7	0.584 (0.101, 0.844)
			P09	16.0	4.3% (-19.3%, 27.9%)	77.3	0.258 (-0.112, 0.566)
			P10	-4.2	-1.2% (-34.3%, 31.8%)	108.6	0.024 (-0.689, 0.713)
		P05	P06	15.4	4.8% (-18.1%, 27.7%)	72.6	-0.467 (-0.851, 0.242)
			P07	13.8	4.8% (-29.2%, 38.7%)	104.5	-0.397 (-0.793, 0.234)
			P08	3.3	1.1% (-21.7%, 23.8%)	73.1	-0.254 (-0.782, 0.486)
			P09	19.7	6% (-14.1%, 26%)	64.9	-0.254 (-0.711, 0.353)
			P10	-20.2	-5.7% (-35%, 23.7%)	98.3	-0.102 (-0.631, 0.492)
		P06	P07	15.5	6.1% (-45.5%, 57.6%)	149.8	-0.365 (-0.741, 0.185)
			P08	-12.1	-3.7% (-14.6%, 7.1%)	34.7	0.558 (-0.016, 0.856)
			P09	-10.1	-3.4% (-8.8%, 2%)	16.0	0.544 (-0.204, 0.891)
			P10	-35.5	-10.4% (-33.5%, 12.6%)	76.5	0.144 (-0.254, 0.5)
		P07	P08	-10.5	-3.8% (-18.5%, 11%)	43.0	0.72 (0.296, 0.907)
			P09	-26.4	-9.3% (-25.2%, 6.5%)	41.1	0.283 (-0.125, 0.609)
			P10	-40.0	-12.3% (-38.5%, 13.8%)	79.9	0.263 (-0.269, 0.672)
		P08	P09	-10.1	-3.4% (-8.5%, 1.8%)	15.6	0.444 (-0.355, 0.868)
			P10	-25.5	-7.4% (-22.5%, 7.8%)	49.8	0.534 (0.032, 0.821)
		P09	P10	-5.1	-1.4% (-20.9%, 18%)	60.6	-0.379 (-0.836, 0.389)

LIC (15,Inf]

This section looks into the repeatability and reproducibility for subjects with LIC \(\in\) (15,Inf].

Repeatability analysis

The number of pairs for test-retest repeatability analysis by protocol, field strength, and lobe is listed below.

Overall

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol and field strength across all segments/lobes below.

Test-retest repeatability analysis by protocol and field strength across all segments/lobes.

Protocol	Field	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	12.0	1.2% (-15.3%, 17.6%)	150.1	0.93 (0.893, 0.954)	< 0.001
P01	3.0T	-40.2	-2.2% (-21%, 16.7%)	317.9	0.926 (0.887, 0.952)	< 0.001
P02	1.5T	13.4	2.2% (-15.5%, 19.9%)	138.6	0.93 (0.894, 0.955)	< 0.001
P02	3.0T	10.2	0.8% (-26.7%, 28.3%)	400.4	0.883 (0.825, 0.923)	< 0.001
P04	1.5T	-4.4	-0.3% (-23.6%, 23.1%)	200.7	0.857 (0.787, 0.906)	< 0.001
P04	3.0T	21.8	1.3% (-48.6%, 51.3%)	418.7	0.887 (0.831, 0.926)	< 0.001
P08	1.5T	6.8	1.4% (-23.6%, 26.5%)	171.3	0.859 (0.789, 0.907)	< 0.001
P08	3.0T	20.1	3.2% (-47.1%, 53.5%)	357.9	0.844 (0.768, 0.897)	< 0.001

By lobe

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol, field strength, and lobe below.

Test-retest repeatability analysis by protocol, field strength, and lobe.

Protocol	Field	Lobe	Bias	Bias (%) (LoA %)	CR	ICC (95% CI)	p-value
P01	1.5T	Left	27.4	2.7% (-13.8%, 19.3%)	147.1	0.92 (0.86, 0.955)	< 0.001
P01	1.5T	Right	-7.3	-0.7% (-16.5%, 15%)	147.1	0.939 (0.885, 0.968)	< 0.001
P01	3.0T	Left	-50.0	-2.7% (-24.7%, 19.3%)	355.2	0.905 (0.835, 0.947)	< 0.001
P01	3.0T	Right	-27.9	-1.5% (-15.8%, 12.8%)	267.0	0.95 (0.904, 0.974)	< 0.001
P02	1.5T	Left	10.2	1.8% (-17.6%, 21.1%)	152.5	0.908 (0.84, 0.948)	< 0.001
P02	1.5T	Right	17.4	2.7% (-12.9%, 18.4%)	120.6	0.951 (0.906, 0.974)	< 0.001
P02	3.0T	Left	48.6	2.8% (-30.2%, 35.8%)	468.4	0.785 (0.641, 0.875)	< 0.001
P02	3.0T	Right	-37.9	-1.6% (-19.5%, 16.2%)	272.3	0.952 (0.909, 0.975)	< 0.001
P04	1.5T	Left	-2.2	0% (-25%, 25%)	199.1	0.849 (0.743, 0.914)	< 0.001
P04	1.5T	Right	-7.1	-0.6% (-22.1%, 20.9%)	205.4	0.849 (0.725, 0.92)	< 0.001
P04	3.0T	Left	33.1	3.5% (-47.1%, 54.2%)	377.1	0.9 (0.825, 0.943)	< 0.001
P04	3.0T	Right	7.8	-1.4% (-50.7%, 47.9%)	469.5	0.767 (0.591, 0.874)	< 0.001
P08	1.5T	Left	5.8	1.4% (-25.4%, 28.3%)	161.7	0.866 (0.769, 0.924)	< 0.001
P08	1.5T	Right	8.0	1.4% (-21.5%, 24.4%)	184.9	0.816 (0.67, 0.902)	< 0.001
P08	3.0T	Left	17.2	3.3% (-51.2%, 57.8%)	304.5	0.766 (0.613, 0.864)	< 0.001
P08	3.0T	Right	23.8	3.1% (-42.1%, 48.4%)	419.7	0.767 (0.592, 0.874)	< 0.001

Reproducibility analysis

Overall

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized across all segments/lobes below.

Between-protocol reproducibility analysis across all segments/lobes for smaller values.

Field	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	P01	P02	0.7	NA	NA	NA
		P03	17.8	NA	NA	NA
		P05	30.3	NA	NA	NA
		P06	99.4	NA	NA	NA
		P07	25.1	NA	NA	NA
		P08	19.6	NA	NA	NA
		P09	37.0	NA	NA	NA
		P10	18.8	NA	NA	NA
	P02	P03	17.1	NA	NA	NA
		P05	29.6	NA	NA	NA
		P06	98.7	NA	NA	NA
		P07	24.3	NA	NA	NA
		P08	18.9	NA	NA	NA
		P09	36.3	NA	NA	NA
		P10	18.0	NA	NA	NA
	P03	P04	54.9	44.5% (-107.8%, 196.9%)	214.0	0.034 (-1, NaN)
		P05	50.4	32.3% (-55.2%, 119.8%)	107.2	0.566 (-0.144, 0.891)
		P06	59.6	24.1% (-4.7%, 52.9%)	60.9	0.107 (-1, NaN)
		P07	14.0	6.9% (-0.6%, 14.4%)	12.2	0.931 (0.301, 0.995)
		P08	6.8	8% (-39.7%, 55.7%)	64.2	0.875 (0.348, 0.982)
		P09	85.3	54.1% (-16.7%, 125%)	104.4	0.309 (-0.156, 0.662)
		P10	23.5	9.8% (-31.2%, 50.7%)	87.2	0.497 (-0.257, 0.875)
	P04	P05	25.5	12.6% (-24.2%, 49.3%)	72.0	0.864 (-1, NaN)
		P06	9.0	NA	NA	NA
		P07	-16.6	-21.1% (-144.4%, 102.2%)	171.4	0.421 (-0.505, 0.897)
		P08	5.9	-6.8% (-110.3%, 96.7%)	158.5	0.276 (-0.188, 0.64)
		P09	8.8	-8.2% (-110%, 93.6%)	131.5	0.684 (-1, NaN)
		P10	-28.3	-32.2% (-172.7%, 108.2%)	183.6	0.283 (-1, NaN)
	P05	P06	11.8	5.5% (-30.3%, 41.2%)	86.1	-0.014 (-0.658, 0.641)
		P07	-15.8	-14.3% (-94.5%, 65.8%)	117.6	0.598 (-0.018, 0.885)
		P08	-50.8	-31.2% (-107.7%, 45.4%)	95.6	0.541 (0.069, 0.815)
		P09	34.5	13.8% (-64.4%, 92%)	125.6	0.505 (-0.278, 0.884)
		P10	22.1	7.4% (-81%, 95.9%)	126.0	0.427 (-0.309, 0.843)
	P06	P07	-47.0	-19.4% (-54.1%, 15.4%)	75.7	0.275 (-1, NaN)
		P08	-28.9	-12.6% (-54.9%, 29.8%)	103.0	0.013 (-0.607, 0.623)
		P09	12.2	7% (-69.3%, 83.4%)	156.7	-0.229 (-0.85, 0.658)
		P10	23.6	10.1% (-65.9%, 86%)	179.9	-0.792 (-1, 0.998)
	P07	P08	-9.5	-5.5% (-27.5%, 16.6%)	46.2	0.898 (0.526, 0.982)
		P09	54.2	30.3% (-16.7%, 77.3%)	78.8	0.371 (-0.218, 0.762)
		P10	37.6	21.6% (-41.9%, 85.1%)	126.0	0.193 (-0.319, 0.618)
	P08	P09	51.3	34.9% (-18.4%, 88.3%)	71.0	0.691 (0.155, 0.912)
		P10	28.0	12.2% (-74.5%, 99%)	136.8	0.257 (-0.53, 0.807)
	P09	P10	-29.3	-21.5% (-101.2%, 58.3%)	104.2	0.547 (0.073, 0.82)
3.0T	P03	P04	45.6	21.8% (-128.4%, 172%)	306.6	-0.19 (-0.648, 0.369)
		P05	58.8	28.7% (-70.4%, 127.9%)	220.5	0.265 (-0.156, 0.604)
		P06	92.7	58.9% (-77.8%, 195.6%)	207.1	0.394 (-0.122, 0.742)
		P07	89.9	42.6% (-48%, 133.1%)	186.7	0.342 (-0.033, 0.633)
		P08	21.0	15.5% (-111.3%, 142.4%)	248.5	0.02 (-0.766, 0.782)
		P09	121.6	36.5% (25.1%, 47.9%)	28.3	0.009 (-1, NaN)
		P10	116.1	49.6% (-77.4%, 176.6%)	283.1	-0.008 (-0.504, 0.493)
	P04	P05	48.8	21.1% (-119.8%, 161.9%)	227.6	0.258 (-0.149, 0.59)
		P06	47.5	20.1% (-134.4%, 174.7%)	320.7	0.068 (-0.441, 0.545)
		P07	66.1	31.3% (-61.2%, 123.9%)	189.7	0.244 (-0.171, 0.586)
		P08	13.9	4% (-118.3%, 126.3%)	258.8	0.139 (-0.441, 0.636)
		P09	0.5	-5.2% (-105.1%, 94.6%)	222.0	0.165 (-0.631, 0.792)
		P10	87.5	35.1% (-126.4%, 196.7%)	277.0	-0.039 (-0.439, 0.374)
	P05	P06	9.1	4.5% (-116.1%, 125%)	243.1	0.312 (-0.111, 0.64)
		P07	-1.4	-4.5% (-93.4%, 84.4%)	171.1	0.632 (0.286, 0.833)
		P08	-21.2	-4.6% (-67.5%, 58.2%)	150.2	0.625 (0.285, 0.825)
		P09	-11.9	-7.7% (-58.4%, 43%)	143.9	0.499 (-0.699, 0.961)
		P10	54.3	22.7% (-99.9%, 145.2%)	234.7	0.056 (-0.325, 0.422)
	P06	P07	-13.7	-8.9% (-120.7%, 102.9%)	261.0	0.21 (-0.308, 0.632)
		P08	-20.8	-12.2% (-135.5%, 111%)	212.1	0.468 (0.075, 0.735)
		P09	43.1	11.9% (-86.4%, 110.3%)	271.9	-0.549 (-0.939, 0.457)
		P10	79.6	37.1% (-101.1%, 175.2%)	253.4	0.095 (-0.232, 0.403)
	P07	P08	-8.9	-3.9% (-78.4%, 70.6%)	186.3	0.501 (-0.066, 0.824)
		P09	-19.0	-9.8% (-96.5%, 76.8%)	239.9	-0.481 (-0.875, 0.296)
		P10	50.5	26% (-89.4%, 141.5%)	204.0	0.325 (-0.198, 0.704)
	P08	P09	60.6	21.1% (-34%, 76.2%)	165.8	-0.035 (-0.794, 0.766)
		P10	51.9	15.7% (-113.9%, 145.3%)	247.7	0.003 (-0.38, 0.386)
	P09	P10	98.2	52.8% (-72.8%, 178.3%)	197.2	0.139 (-0.322, 0.546)

By lobe

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized by lobe below.

Between-protocol reproducibility analysis of R2* by lobe for smaller values.

Field	Lobe	Protocol x	Protocol y	Bias	Bias (%) (LoA %)	CR	CCC (95% CI)
1.5T	Left	P01	P02	0.7	NA	NA	NA
			P03	17.8	NA	NA	NA
			P05	30.3	NA	NA	NA
			P06	99.4	NA	NA	NA
			P07	25.1	NA	NA	NA
			P08	19.6	NA	NA	NA
			P09	37.0	NA	NA	NA
			P10	18.8	NA	NA	NA
		P02	P03	17.1	NA	NA	NA
			P05	29.6	NA	NA	NA
			P06	98.7	NA	NA	NA
			P07	24.3	NA	NA	NA
			P08	18.9	NA	NA	NA
			P09	36.3	NA	NA	NA
			P10	18.0	NA	NA	NA
		P03	P04	54.9	44.5% (-107.8%, 196.9%)	214.0	0.034 (-1, NaN)
			P05	50.4	32.3% (-55.2%, 119.8%)	107.2	0.566 (-0.144, 0.891)
			P06	59.6	24.1% (-4.7%, 52.9%)	60.9	0.107 (-1, NaN)
			P07	14.0	6.9% (-0.6%, 14.4%)	12.2	0.931 (0.301, 0.995)
			P08	6.8	8% (-39.7%, 55.7%)	64.2	0.875 (0.348, 0.982)
			P09	85.3	54.1% (-16.7%, 125%)	104.4	0.309 (-0.156, 0.662)
			P10	23.5	9.8% (-31.2%, 50.7%)	87.2	0.497 (-0.257, 0.875)
		P04	P05	25.5	12.6% (-24.2%, 49.3%)	72.0	0.864 (-1, NaN)
			P06	9.0	NA	NA	NA
			P07	-16.6	-21.1% (-144.4%, 102.2%)	171.4	0.421 (-0.505, 0.897)
			P08	5.9	-6.8% (-110.3%, 96.7%)	158.5	0.276 (-0.188, 0.64)
			P09	8.8	-8.2% (-110%, 93.6%)	131.5	0.684 (-1, NaN)
			P10	-28.3	-32.2% (-172.7%, 108.2%)	183.6	0.283 (-1, NaN)
		P05	P06	13.5	6.5% (-37%, 50%)	105.1	-0.244 (-0.672, 0.307)
			P07	-38.4	-27.5% (-113.2%, 58.3%)	103.2	0.572 (-0.17, 0.9)
			P08	-65.8	-43.5% (-139.6%, 52.7%)	118.1	0.432 (-0.318, 0.849)
			P09	34.5	13.8% (-64.4%, 92%)	125.6	0.505 (-0.278, 0.884)
			P10	13.2	0.2% (-87.6%, 88%)	128.3	0.449 (-0.313, 0.86)
		P06	P07	-74.3	NA	NA	NA
			P08	-32.5	-14.6% (-65.6%, 36.3%)	124.9	-0.274 (-0.795, 0.481)
			P09	12.2	7% (-69.3%, 83.4%)	156.7	-0.229 (-0.85, 0.658)
			P10	23.6	10.1% (-65.9%, 86%)	179.9	-0.792 (-1, 0.998)
		P07	P08	-11.7	-6.7% (-30.5%, 17.2%)	50.2	0.838 (0.191, 0.977)
			P09	54.2	30.3% (-16.7%, 77.3%)	78.8	0.371 (-0.218, 0.762)
			P10	44.9	24.4% (-35.3%, 84%)	112.3	0.228 (-0.437, 0.732)
		P08	P09	44.1	33.1% (-25.7%, 92%)	69.2	0.775 (0.199, 0.953)
			P10	-2.7	-6% (-85%, 72.9%)	119.0	0.572 (-0.511, 0.953)
		P09	P10	-31.5	-23.9% (-112%, 64.1%)	115.6	0.361 (-0.194, 0.741)
	Right	P05	P06	6.6	NA	NA	NA
			P07	29.3	12% (-33.7%, 57.6%)	117.4	-0.054 (-1, NaN)
			P08	-28.2	-12.7% (-36.8%, 11.4%)	46.1	0.742 (-1, NaN)
			P10	76.0	NA	NA	NA
		P06	P07	-19.7	NA	NA	NA
			P08	-18.2	NA	NA	NA
		P07	P08	1.5	NA	NA	NA
			P10	19.4	14.5% (-82.6%, 111.7%)	203.4	0.028 (-1, NaN)
		P08	P09	87.6	NA	NA	NA
			P10	89.5	48.7% (-11%, 108.5%)	86.9	0.042 (-1, NaN)
		P09	P10	-19.5	-10.3% (-29.6%, 9%)	27.5	0.934 (-1, NaN)
3.0T	Left	P03	P04	31.0	18.6% (-146.4%, 183.5%)	321.1	-0.115 (-0.723, 0.594)
			P05	46.7	18.5% (-66.9%, 103.9%)	194.6	0.32 (-0.234, 0.717)
			P06	90.6	58.6% (-89.1%, 206.3%)	223.4	0.399 (-0.186, 0.775)
			P07	67.5	28.7% (-49.6%, 107%)	177.7	0.408 (-0.111, 0.752)
			P08	21.0	15.5% (-111.3%, 142.4%)	248.5	0.02 (-0.766, 0.782)
			P09	121.6	36.5% (25.1%, 47.9%)	28.3	0.009 (-1, NaN)
			P10	116.1	49.6% (-77.4%, 176.6%)	283.1	-0.008 (-0.504, 0.493)
		P04	P05	42.3	13.9% (-132.4%, 160.2%)	234.7	0.286 (-0.184, 0.649)
			P06	33.5	15.6% (-142.3%, 173.6%)	318.5	0.105 (-0.448, 0.6)
			P07	62.6	22.7% (-54.7%, 100.1%)	192.5	0.168 (-0.308, 0.577)
			P08	13.9	4% (-118.3%, 126.3%)	258.8	0.139 (-0.441, 0.636)
			P09	0.5	-5.2% (-105.1%, 94.6%)	222.0	0.165 (-0.631, 0.792)
			P10	87.5	35.1% (-126.4%, 196.7%)	277.0	-0.039 (-0.439, 0.374)
		P05	P06	13.2	6.1% (-119.3%, 131.5%)	236.6	0.432 (-0.039, 0.746)
			P07	-4.8	-8.3% (-101.6%, 85%)	192.1	0.449 (-0.04, 0.764)
			P08	-12.7	-0.3% (-68.2%, 67.7%)	162.8	0.637 (0.224, 0.856)
			P09	-11.9	-7.7% (-58.4%, 43%)	143.9	0.499 (-0.699, 0.961)
			P10	33.7	9.9% (-121.1%, 140.9%)	254.9	0.088 (-0.421, 0.554)
		P06	P07	-13.7	-8.9% (-120.7%, 102.9%)	261.0	0.21 (-0.308, 0.632)
			P08	-28.7	-16.2% (-152.4%, 120%)	233.0	0.416 (-0.041, 0.729)
			P09	43.1	11.9% (-86.4%, 110.3%)	271.9	-0.549 (-0.939, 0.457)
			P10	51.7	18.4% (-106.4%, 143.2%)	264.3	0.14 (-0.298, 0.529)
		P07	P08	-6.0	-3.2% (-81.1%, 74.8%)	194.3	0.484 (-0.123, 0.827)
			P09	-19.0	-9.8% (-96.5%, 76.8%)	239.9	-0.481 (-0.875, 0.296)
			P10	39.1	21.4% (-95.2%, 138%)	197.9	0.402 (-0.173, 0.773)
		P08	P09	60.6	21.1% (-34%, 76.2%)	165.8	-0.035 (-0.794, 0.766)
			P10	5.1	-9.9% (-132.3%, 112.6%)	242.6	0.119 (-0.447, 0.617)
		P09	P10	98.2	52.8% (-72.8%, 178.3%)	197.2	0.139 (-0.322, 0.546)
	Right	P03	P04	71.1	27.5% (-115.7%, 170.7%)	319.3	-0.58 (-0.982, 0.777)
			P05	85.4	51.2% (-71.6%, 174.1%)	287.7	0.094 (-0.583, 0.694)
			P06	107.3	NA	NA	NA
			P07	145.9	77.2% (-15.3%, 169.7%)	183.7	0.14 (-0.325, 0.55)
		P04	P05	73.4	48% (-71.9%, 167.9%)	222.9	-0.163 (-0.763, 0.589)
			P06	216.0	NA	NA	NA
			P07	74.9	52.9% (-72.8%, 178.6%)	210.2	-0.081 (-0.708, 0.617)
		P05	P06	-4.9	-1% (-116%, 114.1%)	291.8	-0.816 (-0.98, 0.004)
			P07	9.0	7% (-71.9%, 85.9%)	95.7	0.908 (0.41, 0.989)
			P08	-46.8	-17.8% (-56.4%, 20.8%)	101.1	0.407 (-0.34, 0.839)
			P10	107.9	56% (-14.6%, 126.6%)	141.9	0.065 (-0.28, 0.396)
		P06	P08	12.9	4.8% (-16.6%, 26.3%)	58.3	0.624 (-0.391, 0.954)
			P10	168.9	96.9% (-23.5%, 217.3%)	94.3	0.135 (-0.058, 0.317)
		P07	P08	-41.6	NA	NA	NA
			P10	176.3	NA	NA	NA
		P08	P10	154.7	71.8% (13.3%, 130.4%)	95.7	0.079 (-0.103, 0.255)