Tabcat Renewal Markdown
Mark Sanderson-Cimino
2024-07-17
| The following analyses are separated into two overall samples. The first includes all ALLFTD participants and investigates the performance of the UDS measures. We analyzed the overall sample with UDS measures separately because this is much larger group (n=2559) than the subset with TabCAT-EXAMINER (n=825). |
| The outline on the left points to the individual analyses. Within those sections there are clickable tabs that present sub analyses. For example, “Table 1 UDS” has 3 sub analyses in the tab, presenting data for the full sample, by genetic mutation, and by baseline CDR. |
Table 1 UDS
Full Sample Description
Provides a description of the full ALLFTD sample at baseline.
| Overall | |
|---|---|
| n | 2559 |
| age_at_visit (mean (SD)) | 58.95 (14.20) |
| education (mean (SD)) | 15.87 (2.63) |
| ftldcdr_sb (mean (SD)) | 4.93 (5.37) |
| sex = Male (%) | 1270 ( 49.6) |
| ftldcdr_glob (%) | |
| 0 | 783 ( 30.6) |
| 0.5 | 450 ( 17.6) |
| 1 | 648 ( 25.3) |
| 2 | 546 ( 21.3) |
| 3 | 132 ( 5.2) |
| genetic_factor (%) | |
| C9 | 282 ( 14.1) |
| GRN | 133 ( 6.7) |
| MAPT | 129 ( 6.5) |
| none | 1449 ( 72.7) |
| family_gene.controlvscase = Carrier (%) | 22 (100.0) |
Sample by genetic mutation status
Provides a description of the sample by genetic status. Note, in analyses those with C9 and GRN are coded as GRN.
| C9 | GRN | MAPT | none | p | test | |
|---|---|---|---|---|---|---|
| n | 282 | 133 | 129 | 1449 | ||
| age_at_visit (mean (SD)) | 51.20 (14.62) | 55.60 (13.59) | 45.28 (13.68) | 61.50 (12.83) | <0.001 | |
| education (mean (SD)) | 15.72 (2.50) | 15.44 (2.90) | 15.52 (2.49) | 16.00 (2.61) | 0.019 | |
| ftldcdr_sb (mean (SD)) | 3.64 (5.54) | 4.60 (6.71) | 3.24 (5.38) | 5.35 (5.20) | <0.001 | |
| sex = Male (%) | 121 ( 42.9) | 64 ( 48.1) | 54 ( 41.9) | 749 (51.7) | 0.013 | |
| ftldcdr_glob (%) | <0.001 | |||||
| 0 | 147 ( 52.1) | 68 ( 51.1) | 69 ( 53.5) | 336 (23.2) | ||
| 0.5 | 40 ( 14.2) | 13 ( 9.8) | 24 ( 18.6) | 278 (19.2) | ||
| 1 | 33 ( 11.7) | 22 ( 16.5) | 11 ( 8.5) | 421 (29.1) | ||
| 2 | 53 ( 18.8) | 17 ( 12.8) | 20 ( 15.5) | 340 (23.5) | ||
| 3 | 9 ( 3.2) | 13 ( 9.8) | 5 ( 3.9) | 74 ( 5.1) | ||
| family_gene.controlvscase = Carrier (%) | 12 (100.0) | 7 (100.0) | 2 (100.0) | 0 ( NaN) | NA |
| Overall | C9 | GRN | MAPT | none | p | test | |
|---|---|---|---|---|---|---|---|
| n | 2559 | 282 | 133 | 129 | 1449 | ||
| moca_total (mean (SD)) | 21.92 (6.89) | 24.35 (5.96) | 22.60 (7.73) | 23.56 (6.59) | 21.36 (6.76) | <0.001 | |
| uds3_ef (mean (SD)) | -1.21 (1.45) | -0.62 (1.35) | -0.75 (1.46) | -0.50 (1.42) | -1.42 (1.39) | <0.001 | |
| traila_ratio (mean (SD)) | 0.76 (0.42) | 0.89 (0.41) | 0.88 (0.42) | 1.00 (0.47) | 0.71 (0.41) | <0.001 | |
| trailb_ratio (mean (SD)) | 0.32 (0.20) | 0.38 (0.18) | 0.36 (0.18) | 0.44 (0.22) | 0.29 (0.20) | <0.001 | |
| dig_fwd_sum (mean (SD)) | 7.35 (2.76) | 8.08 (2.72) | 7.44 (2.89) | 8.29 (2.51) | 7.19 (2.72) | <0.001 | |
| dig_back_sum (mean (SD)) | 5.74 (2.84) | 6.58 (2.84) | 6.03 (3.06) | 7.03 (2.85) | 5.49 (2.74) | <0.001 | |
| mint_total (mean (SD)) | 23.70 (8.25) | 26.75 (4.65) | 25.78 (6.75) | 24.15 (6.74) | 22.94 (8.80) | <0.001 | |
| flu_animal (mean (SD)) | 16.10 (8.76) | 19.81 (7.81) | 19.14 (8.99) | 19.22 (7.87) | 14.78 (8.56) | <0.001 | |
| flu_veg (mean (SD)) | 10.40 (5.95) | 12.39 (5.28) | 12.67 (6.17) | 12.08 (5.17) | 9.67 (5.92) | <0.001 | |
| flu_fwords (mean (SD)) | 10.49 (6.05) | 12.28 (5.63) | 12.47 (7.19) | 12.71 (6.57) | 9.75 (5.79) | <0.001 | |
| flu_lwords (mean (SD)) | 9.94 (5.79) | 11.70 (5.57) | 11.15 (6.43) | 12.26 (6.12) | 9.26 (5.52) | <0.001 | |
| benson_copy (mean (SD)) | 14.42 (3.06) | 15.02 (2.07) | 14.45 (3.07) | 15.31 (2.13) | 14.23 (3.15) | <0.001 | |
| benson_delay (mean (SD)) | 9.61 (4.64) | 11.11 (3.43) | 10.42 (3.93) | 10.82 (4.84) | 9.09 (4.79) | <0.001 | |
| craft_v_immed (mean (SD)) | 16.28 (9.20) | 19.50 (8.55) | 18.31 (8.12) | 18.56 (8.70) | 15.31 (9.17) | <0.001 | |
| craft_v_delay (mean (SD)) | 13.77 (9.15) | 17.48 (8.32) | 15.92 (8.24) | 15.78 (9.38) | 12.75 (9.06) | <0.001 |
Sample by baseline CDR+NACC-FTLD Global
Provides a description of the sample by CDR+NACC-FTLD Global score.
| 0 | 0.5 | 1 | 2 | 3 | p | test | |
|---|---|---|---|---|---|---|---|
| n | 783 | 450 | 648 | 546 | 132 | ||
| age_at_visit (mean (SD)) | 45.25 (13.57) | 63.53 (11.51) | 65.83 (7.92) | 65.09 (9.19) | 65.42 (9.96) | <0.001 | |
| education (mean (SD)) | 16.07 (2.48) | 15.90 (2.70) | 16.00 (2.65) | 15.53 (2.66) | 15.45 (2.91) | 0.001 | |
| ftldcdr_sb (mean (SD)) | 0.00 (0.00) | 1.94 (0.99) | 5.40 (1.48) | 10.44 (2.63) | 19.21 (3.31) | <0.001 | |
| sex = Male (%) | 308 (39.3) | 219 (48.7) | 384 ( 59.3) | 311 ( 57.0) | 48 ( 36.4) | <0.001 | |
| genetic_factor (%) | <0.001 | ||||||
| C9 | 147 (23.7) | 40 (11.3) | 33 ( 6.8) | 53 ( 12.3) | 9 ( 8.9) | ||
| GRN | 68 (11.0) | 13 ( 3.7) | 22 ( 4.5) | 17 ( 4.0) | 13 ( 12.9) | ||
| MAPT | 69 (11.1) | 24 ( 6.8) | 11 ( 2.3) | 20 ( 4.7) | 5 ( 5.0) | ||
| none | 336 (54.2) | 278 (78.3) | 421 ( 86.4) | 340 ( 79.1) | 74 ( 73.3) | ||
| family_gene.controlvscase = Carrier (%) | 0 ( NaN) | 0 ( NaN) | 9 (100.0) | 10 (100.0) | 3 (100.0) | NA |
| Overall | 0 | 0.5 | 1 | 2 | 3 | p | test | |
|---|---|---|---|---|---|---|---|---|
| n | 2559 | 783 | 450 | 648 | 546 | 132 | ||
| moca_total (mean (SD)) | 21.92 (6.89) | 27.32 (2.21) | 23.56 (4.19) | 19.45 (5.88) | 15.80 (6.91) | 8.68 (5.81) | <0.001 | |
| uds3_ef (mean (SD)) | -1.21 (1.45) | 0.23 (0.74) | -1.22 (1.05) | -1.96 (1.08) | -2.47 (0.92) | -2.84 (0.90) | <0.001 | |
| traila_ratio (mean (SD)) | 0.76 (0.42) | 1.11 (0.37) | 0.70 (0.30) | 0.55 (0.29) | 0.46 (0.26) | 0.30 (0.22) | <0.001 | |
| trailb_ratio (mean (SD)) | 0.32 (0.20) | 0.47 (0.17) | 0.27 (0.14) | 0.21 (0.14) | 0.17 (0.12) | 0.12 (0.15) | <0.001 | |
| dig_fwd_sum (mean (SD)) | 7.35 (2.76) | 8.98 (2.37) | 7.07 (2.38) | 6.55 (2.71) | 6.04 (2.45) | 5.49 (2.30) | <0.001 | |
| dig_back_sum (mean (SD)) | 5.74 (2.84) | 7.73 (2.29) | 5.71 (2.26) | 4.76 (2.54) | 3.86 (2.36) | 2.33 (2.28) | <0.001 | |
| mint_total (mean (SD)) | 23.70 (8.25) | 28.51 (1.61) | 24.34 (7.21) | 21.91 (9.17) | 20.76 (9.49) | 19.29 (8.93) | <0.001 | |
| flu_animal (mean (SD)) | 16.10 (8.76) | 24.01 (5.72) | 16.34 (6.81) | 11.70 (6.57) | 9.02 (6.01) | 5.21 (4.47) | <0.001 | |
| flu_veg (mean (SD)) | 10.40 (5.95) | 15.46 (4.16) | 10.43 (4.65) | 7.57 (4.83) | 5.78 (4.13) | 4.28 (5.17) | <0.001 | |
| flu_fwords (mean (SD)) | 10.49 (6.05) | 15.35 (4.63) | 10.52 (4.73) | 7.98 (4.93) | 5.94 (4.49) | 3.48 (3.44) | <0.001 | |
| flu_lwords (mean (SD)) | 9.94 (5.79) | 14.49 (4.36) | 10.02 (4.88) | 7.53 (4.78) | 5.57 (4.17) | 3.19 (3.04) | <0.001 | |
| benson_copy (mean (SD)) | 14.42 (3.06) | 15.67 (1.29) | 14.80 (2.20) | 13.99 (3.21) | 12.92 (4.05) | 9.51 (5.25) | <0.001 | |
| benson_delay (mean (SD)) | 9.61 (4.64) | 12.78 (2.59) | 10.09 (3.65) | 7.96 (4.42) | 6.09 (4.79) | 3.89 (3.42) | <0.001 | |
| craft_v_immed (mean (SD)) | 16.28 (9.20) | 22.73 (6.54) | 17.33 (8.16) | 12.48 (8.15) | 9.65 (7.57) | 5.89 (6.56) | <0.001 | |
| craft_v_delay (mean (SD)) | 13.77 (9.15) | 20.59 (6.65) | 14.48 (8.08) | 9.64 (7.72) | 6.99 (6.98) | 3.52 (4.93) | <0.001 |
Table 1 TabCAT
Full Sample Description
Provides a description of the full TabCAT-EXAMINER sample at baseline.
| Overall | |
|---|---|
| n | 825 |
| age_at_visit (mean (SD)) | 55.92 (14.80) |
| educ (mean (SD)) | 15.95 (2.53) |
| ftldcdr_sb (mean (SD)) | 2.67 (3.81) |
| sex_at_birth = M (%) | 397 (48.2) |
| ftldcdr_glob (%) | |
| 0 | 386 (48.7) |
| 0.5 | 151 (19.1) |
| 1 | 161 (20.3) |
| 2 | 86 (10.9) |
| 3 | 8 ( 1.0) |
| genetic_status_edit (%) | |
| C9 | 95 (11.5) |
| GRN | 35 ( 4.2) |
| MAPT | 51 ( 6.2) |
| NONE | 257 (31.2) |
| OTHER | 10 ( 1.2) |
| UNKNOWN | 377 (45.7) |
| control_carry = FamControl (%) | 312 (63.3) |
TabCAT-EXAMINER Sample by genetic mutation status
Provides a description of the sample by genetic status. Note, in analyses those with C9 and GRN are coded as GRN.
| C9 | GRN | MAPT | NONE | OTHER | UNKNOWN | p | test | |
|---|---|---|---|---|---|---|---|---|
| n | 95 | 35 | 51 | 257 | 10 | 377 | ||
| age_at_visit (mean (SD)) | 50.87 (12.83) | 54.97 (14.92) | 45.45 (12.12) | 58.65 (14.02) | 53.70 (18.09) | 56.90 (15.16) | <0.001 | |
| educ (mean (SD)) | 15.64 (2.27) | 16.26 (2.67) | 15.66 (2.58) | 16.02 (2.60) | 13.90 (2.33) | 16.05 (2.52) | 0.080 | |
| ftldcdr_sb (mean (SD)) | 1.34 (2.89) | 1.43 (3.56) | 2.06 (3.63) | 2.80 (3.96) | 2.28 (3.91) | 3.14 (3.87) | <0.001 | |
| sex_at_birth = M (%) | 44 (46.3) | 20 (57.1) | 19 (37.3) | 120 ( 46.7) | 4 ( 40.0) | 190 ( 50.5) | 0.413 | |
| ftldcdr_glob (%) | <0.001 | |||||||
| 0 | 62 (66.0) | 28 (80.0) | 28 (59.6) | 123 ( 48.8) | 4 ( 44.4) | 141 ( 39.7) | ||
| 0.5 | 19 (20.2) | 3 ( 8.6) | 8 (17.0) | 46 ( 18.3) | 3 ( 33.3) | 72 ( 20.3) | ||
| 1 | 7 ( 7.4) | 1 ( 2.9) | 7 (14.9) | 53 ( 21.0) | 1 ( 11.1) | 92 ( 25.9) | ||
| 2 | 6 ( 6.4) | 3 ( 8.6) | 3 ( 6.4) | 27 ( 10.7) | 1 ( 11.1) | 46 ( 13.0) | ||
| 3 | 0 ( 0.0) | 0 ( 0.0) | 1 ( 2.1) | 3 ( 1.2) | 0 ( 0.0) | 4 ( 1.1) | ||
| control_carry = FamControl (%) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 129 (100.0) | 10 (100.0) | 173 (100.0) | <0.001 |
| C9 | GRN | MAPT | NONE | OTHER | UNKNOWN | p | test | |
|---|---|---|---|---|---|---|---|---|
| n | 95 | 35 | 51 | 257 | 10 | 377 | ||
| mocatots (mean (SD)) | 26.17 (3.77) | 25.80 (5.89) | 25.42 (5.46) | 24.11 (6.57) | 22.14 (6.74) | 23.08 (6.14) | <0.001 | |
| tabcat_examiner (mean (SD)) | 0.24 (0.75) | 0.15 (0.84) | 0.31 (0.95) | -0.14 (0.99) | -0.14 (0.69) | -0.30 (1.01) | <0.001 | |
| tabcat_examiner_nafluency (mean (SD)) | 0.23 (0.66) | 0.21 (0.58) | 0.55 (0.66) | 0.11 (0.72) | 0.05 (0.53) | 0.05 (0.74) | 0.003 | |
| uds3_ef (mean (SD)) | -0.13 (1.03) | -0.25 (1.29) | -0.07 (1.46) | -0.63 (1.43) | -1.03 (1.00) | -0.89 (1.46) | <0.001 | |
| traila (mean (SD)) | 28.98 (16.11) | 34.20 (27.74) | 27.68 (19.36) | 37.88 (27.59) | 35.29 (20.93) | 40.46 (28.77) | 0.001 | |
| trailb (mean (SD)) | 78.68 (58.30) | 72.21 (46.04) | 71.30 (67.52) | 93.81 (72.26) | 89.71 (55.20) | 105.37 (79.71) | 0.002 | |
| digforsl (mean (SD)) | 6.86 (1.49) | 6.77 (1.57) | 7.18 (1.33) | 6.50 (1.43) | 7.14 (1.35) | 6.34 (1.54) | <0.001 | |
| digbacls (mean (SD)) | 5.31 (1.47) | 5.03 (1.56) | 5.44 (1.80) | 4.76 (1.64) | 4.86 (2.04) | 4.51 (1.77) | <0.001 | |
| minttots (mean (SD)) | 28.11 (1.91) | 27.88 (2.80) | 25.35 (6.70) | 23.19 (9.66) | 23.50 (11.59) | 24.14 (7.89) | 0.014 | |
| animals (mean (SD)) | 21.87 (7.05) | 22.18 (7.78) | 22.18 (8.32) | 19.30 (8.64) | 14.57 (5.32) | 18.47 (8.96) | <0.001 | |
| veg (mean (SD)) | 14.09 (5.09) | 14.00 (4.57) | 13.47 (5.24) | 12.89 (6.07) | 10.71 (5.68) | 11.98 (6.05) | 0.016 | |
| fwords (mean (SD)) | 14.79 (5.02) | 15.20 (6.22) | 14.12 (6.10) | 13.22 (6.38) | 9.57 (3.95) | 11.59 (6.19) | <0.001 | |
| lwords (mean (SD)) | 13.68 (4.27) | 13.51 (6.11) | 13.08 (6.36) | 12.12 (5.86) | 10.29 (3.35) | 11.01 (5.86) | <0.001 | |
| udsbentc (mean (SD)) | 15.17 (1.45) | 15.17 (1.46) | 15.50 (1.39) | 14.81 (2.55) | 15.00 (1.41) | 14.68 (2.60) | 0.158 | |
| udsbentd (mean (SD)) | 12.20 (3.03) | 11.97 (3.76) | 12.78 (3.52) | 10.86 (4.56) | 9.57 (3.64) | 9.98 (4.51) | <0.001 | |
| craftvrs (mean (SD)) | 23.21 (7.64) | 22.60 (8.28) | 23.26 (8.16) | 20.45 (10.28) | 19.14 (11.61) | 17.26 (9.57) | <0.001 | |
| craftdvr (mean (SD)) | 21.14 (7.78) | 20.31 (8.93) | 20.69 (9.69) | 18.48 (10.31) | 15.71 (10.05) | 14.74 (9.63) | <0.001 |
Sample by baseline CDR+NACC-FTLD Global
Provides a description of the sample by CDR+NACC-FTLD Global score.
| 0 | 0.5 | 1 | 2 | 3 | p | test | |
|---|---|---|---|---|---|---|---|
| n | 386 | 151 | 161 | 86 | 8 | ||
| age_at_visit (mean (SD)) | 47.09 (13.70) | 61.99 (11.58) | 65.75 (7.70) | 65.53 (8.24) | 66.50 (8.28) | <0.001 | |
| educ (mean (SD)) | 16.05 (2.48) | 15.66 (2.63) | 15.99 (2.54) | 15.93 (2.50) | 13.43 (1.99) | 0.050 | |
| ftldcdr_sb (mean (SD)) | 0.00 (0.00) | 1.77 (0.99) | 5.21 (1.54) | 10.01 (2.47) | 17.94 (2.46) | <0.001 | |
| sex_at_birth = M (%) | 146 (37.8) | 81 (53.6) | 98 (60.9) | 55 (64.0) | 4 (50.0) | <0.001 | |
| genetic_status_edit (%) | <0.001 | ||||||
| C9 | 62 (16.1) | 19 (12.6) | 7 ( 4.3) | 6 ( 7.0) | 0 ( 0.0) | ||
| GRN | 28 ( 7.3) | 3 ( 2.0) | 1 ( 0.6) | 3 ( 3.5) | 0 ( 0.0) | ||
| MAPT | 28 ( 7.3) | 8 ( 5.3) | 7 ( 4.3) | 3 ( 3.5) | 1 (12.5) | ||
| NONE | 123 (31.9) | 46 (30.5) | 53 (32.9) | 27 (31.4) | 3 (37.5) | ||
| OTHER | 4 ( 1.0) | 3 ( 2.0) | 1 ( 0.6) | 1 ( 1.2) | 0 ( 0.0) | ||
| UNKNOWN | 141 (36.5) | 72 (47.7) | 92 (57.1) | 46 (53.5) | 4 (50.0) | ||
| control_carry = FamControl (%) | 221 (65.2) | 47 (61.0) | 16 (51.6) | 10 (45.5) | 1 (50.0) | 0.235 |
| 0 | 0.5 | 1 | 2 | 3 | p | test | |
|---|---|---|---|---|---|---|---|
| n | 386 | 151 | 161 | 86 | 8 | ||
| mocatots (mean (SD)) | 27.74 (2.05) | 24.23 (3.82) | 19.52 (6.24) | 15.87 (6.98) | 10.00 (3.93) | <0.001 | |
| tabcat_examiner (mean (SD)) | 0.59 (0.51) | -0.28 (0.70) | -0.92 (0.74) | -1.41 (0.71) | -1.88 (0.47) | <0.001 | |
| tabcat_examiner_nafluency (mean (SD)) | 0.48 (0.52) | -0.24 (0.68) | -0.55 (0.59) | -0.88 (0.64) | -1.12 (NA) | NA | |
| uds3_ef (mean (SD)) | 0.35 (0.72) | -0.83 (1.12) | -1.80 (1.15) | -2.40 (1.04) | -3.28 (0.36) | <0.001 | |
| traila (mean (SD)) | 23.93 (8.79) | 37.26 (19.42) | 51.90 (31.53) | 70.00 (39.53) | 84.14 (40.08) | <0.001 | |
| trailb (mean (SD)) | 56.59 (23.61) | 99.97 (61.41) | 148.14 (85.06) | 203.37 (92.13) | 285.75 (25.28) | <0.001 | |
| digforsl (mean (SD)) | 7.15 (1.29) | 6.28 (1.25) | 5.82 (1.61) | 5.57 (1.38) | 5.12 (0.83) | <0.001 | |
| digbacls (mean (SD)) | 5.60 (1.29) | 4.70 (1.37) | 3.86 (1.68) | 3.04 (1.64) | 2.12 (1.96) | <0.001 | |
| minttots (mean (SD)) | 28.55 (1.65) | 24.69 (7.80) | 20.76 (9.82) | 22.46 (8.77) | 16.00 (12.32) | <0.001 | |
| animals (mean (SD)) | 24.82 (5.68) | 18.70 (7.45) | 12.69 (6.78) | 9.58 (5.76) | 4.29 (2.93) | <0.001 | |
| veg (mean (SD)) | 15.99 (4.47) | 11.48 (4.97) | 8.40 (4.97) | 6.64 (4.03) | 3.67 (1.75) | <0.001 | |
| fwords (mean (SD)) | 16.23 (4.59) | 12.02 (5.20) | 8.41 (5.53) | 6.42 (4.45) | 2.50 (1.69) | <0.001 | |
| lwords (mean (SD)) | 14.87 (4.46) | 11.17 (5.06) | 8.21 (5.17) | 6.31 (4.66) | 2.62 (1.60) | <0.001 | |
| udsbentc (mean (SD)) | 15.55 (1.29) | 14.71 (2.36) | 14.37 (2.57) | 13.17 (3.90) | 12.38 (4.50) | <0.001 | |
| udsbentd (mean (SD)) | 13.11 (2.52) | 10.48 (3.82) | 8.09 (4.34) | 6.14 (4.73) | 2.50 (2.62) | <0.001 | |
| craftvrs (mean (SD)) | 25.13 (6.67) | 19.22 (8.79) | 12.28 (7.76) | 9.87 (8.61) | 2.43 (3.64) | <0.001 | |
| craftdvr (mean (SD)) | 23.29 (6.62) | 16.40 (8.91) | 9.07 (7.69) | 7.28 (7.86) | 3.00 (4.32) | <0.001 |
UDS Forest Plots (Regressions)
Presents associations between each task and the FTLD CDR Sum of Boxes, controlling for age, sex, and education. I then included associations between each cognitive measure and several scales: PSPRS, UPDRS, ALSFRS, NPI, FAQ, SNQ, SBOC, IRI, RSMS. Next, I present associations between each cognitive task and imaging data (controlling for age, education, TIV). The final graph presents associations between scores and NFL (log). For those interested, the numeric values of the associations are also included below the graphs. Using ctrl + find may be helpful as there are quite a few associations/tables.
## [1] "#-----------------------#"
## ftldcdr_sb Estimate CI.low CI.high
## 1 Moca -0.5879184 -0.6134545 -0.5623822
## 2 UDS-EF Composite -0.5478974 -0.5781611 -0.5176336
## 3 Trail B Ratio -0.3553617 -0.3886509 -0.3220724
## 4 Trail A Ratio -0.2885095 -0.3193023 -0.2577167
## 5 DS fwd -0.2422995 -0.2744909 -0.2101082
## 6 DS bwd -0.3544093 -0.3847968 -0.3240218
## 7 MINT -0.2612629 -0.2993843 -0.2231414
## 8 Animals -0.4905436 -0.5199415 -0.4611457
## 9 Veg -0.4454622 -0.4751724 -0.4157519
## 10 Words (F) -0.4120403 -0.4413342 -0.3827463
## 11 Words (L) -0.4029442 -0.4320911 -0.3737973
## 12 Benson Copy -0.2796925 -0.3096507 -0.2497343
## 13 Benson Recall -0.4102557 -0.4392742 -0.3812372
## 14 Craft Immed. -0.3865760 -0.4151680 -0.3579840
## 15 Craft Delay -0.3957941 -0.4245973 -0.3669908
## [1] "#-----------------------#"
## psprs_total Estimate CI.low CI.high
## 1 Moca 0.071949452 0.01674157 0.127157336
## 2 UDS-EF Composite -0.238399242 -0.29520822 -0.181590260
## 3 Trail B Ratio -0.233234183 -0.27975304 -0.186715324
## 4 Trail A Ratio -0.191224367 -0.23753892 -0.144909810
## 5 DS fwd -0.044947072 -0.08692287 -0.002971273
## 6 DS bwd -0.146815670 -0.19195431 -0.101677027
## 7 MINT 0.237006834 0.18548769 0.288525976
## 8 Animals -0.050607737 -0.10405468 0.002839202
## 9 Veg -0.002563708 -0.05287755 0.047750136
## 10 Words (F) -0.157188288 -0.20512578 -0.109250799
## 11 Words (L) -0.159025766 -0.20675245 -0.111299087
## 12 Benson Copy -0.287608843 -0.32703408 -0.248183603
## 13 Benson Recall 0.083429138 0.03702830 0.129829972
## 14 Craft Immed. 0.113920904 0.06734911 0.160492700
## 15 Craft Delay 0.117607538 0.06935507 0.165860007
## updrs_score Estimate CI.low CI.high
## 1 Moca 0.078548045 0.02364202 0.133454075
## 2 UDS-EF Composite -0.218132427 -0.27388444 -0.162380413
## 3 Trail B Ratio -0.249662369 -0.29593744 -0.203387293
## 4 Trail A Ratio -0.194481089 -0.24001002 -0.148952156
## 5 DS fwd -0.048052511 -0.08940436 -0.006700662
## 6 DS bwd -0.134473534 -0.17907873 -0.089868336
## 7 MINT 0.207769379 0.15798030 0.257558461
## 8 Animals -0.056158623 -0.10905530 -0.003261948
## 9 Veg -0.006160131 -0.05598594 0.043665674
## 10 Words (F) -0.137743679 -0.18476986 -0.090717493
## 11 Words (L) -0.153644936 -0.19997035 -0.107319527
## 12 Benson Copy -0.280334819 -0.31915400 -0.241515634
## 13 Benson Recall 0.061816683 0.01662413 0.107009238
## 14 Craft Immed. 0.108431136 0.06226143 0.154600845
## 15 Craft Delay 0.105434474 0.05805619 0.152812760
## alsfrs_sum Estimate CI.low CI.high
## 1 Moca -0.053944678 -0.10764728 -0.0002420765
## 2 UDS-EF Composite 0.166790497 0.11119916 0.2223818332
## 3 Trail B Ratio 0.200602583 0.15510689 0.2460982750
## 4 Trail A Ratio 0.190104351 0.14305983 0.2371488693
## 5 DS fwd 0.054368326 0.01354903 0.0951876238
## 6 DS bwd 0.123581036 0.07918431 0.1679777672
## 7 MINT -0.200723972 -0.25177275 -0.1496751985
## 8 Animals 0.035344202 -0.01689928 0.0875876805
## 9 Veg 0.004422006 -0.04509570 0.0539397152
## 10 Words (F) 0.125563908 0.07913930 0.1719885183
## 11 Words (L) 0.135512116 0.08955339 0.1814708391
## 12 Benson Copy 0.292859067 0.25629554 0.3294225899
## 13 Benson Recall -0.062505683 -0.10749589 -0.0175154731
## 14 Craft Immed. -0.104006469 -0.14888297 -0.0591299678
## 15 Craft Delay -0.101182444 -0.14758764 -0.0547772437
## [1] "#-----------------------#"
## npi_total Estimate CI.low CI.high
## 1 Moca 0.103705014 0.050372097 0.15703793
## 2 UDS-EF Composite 0.073795748 0.021668992 0.12592250
## 3 Trail B Ratio 0.061950160 0.013979914 0.10992041
## 4 Trail A Ratio 0.052584479 0.004954105 0.10021485
## 5 DS fwd 0.036181971 -0.002059812 0.07442375
## 6 DS bwd 0.028908398 -0.012900722 0.07071752
## 7 MINT 0.041499904 -0.006734340 0.08973415
## 8 Animals 0.057969357 0.008481113 0.10745760
## 9 Veg 0.039225784 -0.007260977 0.08571255
## 10 Words (F) 0.048780910 0.004546641 0.09301518
## 11 Words (L) 0.067394349 0.023142506 0.11164619
## 12 Benson Copy 0.104917958 0.066616743 0.14321917
## 13 Benson Recall -0.007137480 -0.051651863 0.03737690
## 14 Craft Immed. -0.009133067 -0.052670551 0.03440442
## 15 Craft Delay -0.023590649 -0.068371870 0.02119057
## faq_total Estimate CI.low CI.high
## 1 Moca -0.09237027 -0.126342361 -0.058398181
## 2 UDS-EF Composite -0.13157064 -0.163967258 -0.099174021
## 3 Trail B Ratio -0.06153034 -0.089352595 -0.033708079
## 4 Trail A Ratio -0.04703942 -0.073504532 -0.020574308
## 5 DS fwd -0.01620046 -0.039902817 0.007501894
## 6 DS bwd -0.04962062 -0.075833598 -0.023407644
## 7 MINT 0.03341363 -0.000345581 0.067172839
## 8 Animals -0.06044458 -0.090897004 -0.029992161
## 9 Veg -0.08085095 -0.109861120 -0.051840778
## 10 Words (F) -0.05089730 -0.078671938 -0.023122654
## 11 Words (L) -0.05420562 -0.081223324 -0.027187924
## 12 Benson Copy -0.03405761 -0.057490171 -0.010625045
## 13 Benson Recall -0.08679709 -0.114491437 -0.059102740
## 14 Craft Immed. -0.04319216 -0.070946541 -0.015437785
## 15 Craft Delay -0.06224799 -0.090270526 -0.034225464
## snq_total Estimate CI.low CI.high
## 1 Moca 0.52222855 0.46830903 0.5761481
## 2 UDS-EF Composite 0.45268440 0.40044619 0.5049226
## 3 Trail B Ratio 0.19933963 0.14946181 0.2492175
## 4 Trail A Ratio 0.17915620 0.12994179 0.2283706
## 5 DS fwd 0.19323916 0.15339676 0.2330816
## 6 DS bwd 0.23052155 0.18716050 0.2738826
## 7 MINT 0.19762156 0.14409056 0.2511526
## 8 Animals 0.37921496 0.32916198 0.4292679
## 9 Veg 0.31461573 0.26714625 0.3620852
## 10 Words (F) 0.31433057 0.27000915 0.3586520
## 11 Words (L) 0.32806885 0.28413984 0.3719978
## 12 Benson Copy 0.08124793 0.03944472 0.1230511
## 13 Benson Recall 0.13893200 0.09100664 0.1868574
## 14 Craft Immed. 0.28966476 0.24571697 0.3336126
## 15 Craft Delay 0.23897348 0.19383840 0.2841086
## sboc_desc_total Estimate CI.low CI.high
## 1 Moca -0.29741517 -0.34926496 -0.245565381
## 2 UDS-EF Composite -0.16059801 -0.21316513 -0.108030897
## 3 Trail B Ratio -0.03119767 -0.07934039 0.016945049
## 4 Trail A Ratio -0.05348831 -0.10019206 -0.006784559
## 5 DS fwd -0.06562414 -0.10448984 -0.026758445
## 6 DS bwd -0.07704149 -0.11933512 -0.034747874
## 7 MINT -0.19568211 -0.24477494 -0.146589289
## 8 Animals -0.19270441 -0.24220874 -0.143200076
## 9 Veg -0.16781840 -0.21429088 -0.121345922
## 10 Words (F) -0.09410617 -0.13870478 -0.049507574
## 11 Words (L) -0.10293648 -0.14712789 -0.058745067
## 12 Benson Copy -0.01847762 -0.05718611 0.020230874
## 13 Benson Recall -0.21838630 -0.26218791 -0.174584687
## 14 Craft Immed. -0.22093423 -0.26321244 -0.178656015
## 15 Craft Delay -0.22407789 -0.26725588 -0.180899908
## sboc_behav_total Estimate CI.low CI.high
## 1 Moca -0.32097206 -0.37567969 -0.26626442
## 2 UDS-EF Composite -0.16175750 -0.21680932 -0.10670569
## 3 Trail B Ratio -0.03714485 -0.08744258 0.01315289
## 4 Trail A Ratio -0.08352625 -0.13376152 -0.03329099
## 5 DS fwd -0.07370237 -0.11431328 -0.03309145
## 6 DS bwd -0.05797410 -0.10183472 -0.01411348
## 7 MINT -0.27664791 -0.32741214 -0.22588367
## 8 Animals -0.19373406 -0.24532492 -0.14214319
## 9 Veg -0.19577224 -0.24420130 -0.14734317
## 10 Words (F) -0.09642285 -0.14340234 -0.04944335
## 11 Words (L) -0.09248909 -0.13900122 -0.04597695
## 12 Benson Copy 0.02824425 -0.01203820 0.06852669
## 13 Benson Recall -0.25130583 -0.29679900 -0.20581266
## 14 Craft Immed. -0.24688580 -0.29109730 -0.20267430
## 15 Craft Delay -0.25786153 -0.30297415 -0.21274891
## iri_emp Estimate CI.low CI.high
## 1 Moca -0.110657380 -0.16758170 -0.0537330555
## 2 UDS-EF Composite -0.044604122 -0.10092875 0.0117205112
## 3 Trail B Ratio -0.040190611 -0.09309253 0.0127113043
## 4 Trail A Ratio -0.054111260 -0.10918413 0.0009616106
## 5 DS fwd -0.018127935 -0.06008170 0.0238258261
## 6 DS bwd -0.021026367 -0.06708148 0.0250287476
## 7 MINT -0.045778733 -0.09519860 0.0036411360
## 8 Animals -0.091963448 -0.14610993 -0.0378169676
## 9 Veg -0.068884266 -0.11997169 -0.0177968377
## 10 Words (F) -0.004116312 -0.05244557 0.0442129423
## 11 Words (L) -0.011089544 -0.05961348 0.0374343936
## 12 Benson Copy -0.116888536 -0.15708051 -0.0766965599
## 13 Benson Recall -0.087526928 -0.13530962 -0.0397442350
## 14 Craft Immed. -0.054126717 -0.10048027 -0.0077731647
## 15 Craft Delay -0.047894141 -0.09588832 0.0001000398
## iri_pt Estimate CI.low CI.high
## 1 Moca -0.0473369438 -0.104522439 0.009848551
## 2 UDS-EF Composite 0.0087815151 -0.047566409 0.065129440
## 3 Trail B Ratio -0.0208568226 -0.073451612 0.031737966
## 4 Trail A Ratio -0.0007638558 -0.056850834 0.055323123
## 5 DS fwd -0.0151822600 -0.056997315 0.026632795
## 6 DS bwd -0.0233787864 -0.068924297 0.022166724
## 7 MINT 0.0396053124 -0.008193271 0.087403896
## 8 Animals -0.0328841768 -0.086766291 0.020997937
## 9 Veg 0.0077421212 -0.043255746 0.058739989
## 10 Words (F) 0.0088773532 -0.039450628 0.057205334
## 11 Words (L) 0.0088195613 -0.039337921 0.056977043
## 12 Benson Copy -0.1283261962 -0.168609727 -0.088042665
## 13 Benson Recall -0.0491958352 -0.097239852 -0.001151818
## 14 Craft Immed. 0.0449757772 -0.001186608 0.091138162
## 15 Craft Delay 0.0357776703 -0.011992242 0.083547583
## rsms_sen Estimate CI.low CI.high
## 1 Moca -0.047245190 -0.09728935 0.002798969
## 2 UDS-EF Composite 0.005713362 -0.04389590 0.055322627
## 3 Trail B Ratio -0.037085108 -0.08255952 0.008389299
## 4 Trail A Ratio -0.023923415 -0.07123174 0.023384909
## 5 DS fwd -0.011566160 -0.04858897 0.025456652
## 6 DS bwd -0.029339936 -0.06982229 0.011142417
## 7 MINT 0.087656193 0.04404320 0.131269186
## 8 Animals 0.008652195 -0.03888358 0.056187966
## 9 Veg 0.015078460 -0.02968048 0.059837401
## 10 Words (F) -0.003865272 -0.04624289 0.038512346
## 11 Words (L) 0.003613030 -0.03865049 0.045876552
## 12 Benson Copy -0.150623508 -0.18564879 -0.115598230
## 13 Benson Recall -0.025314594 -0.06707227 0.016443087
## 14 Craft Immed. 0.017022112 -0.02378652 0.057830742
## 15 Craft Delay 0.019611668 -0.02233970 0.061563041
## rsms_selfpre Estimate CI.low CI.high
## 1 Moca -0.0084331610 -0.060996237 0.04412992
## 2 UDS-EF Composite 0.1149315162 0.063980287 0.16588275
## 3 Trail B Ratio 0.0554730104 0.007852489 0.10309353
## 4 Trail A Ratio 0.0415606351 -0.007990405 0.09111168
## 5 DS fwd 0.0341233535 -0.004199729 0.07244644
## 6 DS bwd 0.0362571057 -0.005636553 0.07815076
## 7 MINT 0.0333983698 -0.011752388 0.07854913
## 8 Animals 0.0696187521 0.020415021 0.11882248
## 9 Veg 0.0599455165 0.013907464 0.10598357
## 10 Words (F) 0.0702001777 0.026582197 0.11381816
## 11 Words (L) 0.0938570952 0.050170696 0.13754349
## 12 Benson Copy -0.0954155213 -0.132334399 -0.05849664
## 13 Benson Recall -0.0001828693 -0.043548414 0.04318268
## 14 Craft Immed. 0.0489607444 0.006669069 0.09125242
## 15 Craft Delay 0.0547385616 0.011376141 0.09810098
## rsms_total Estimate CI.low CI.high
## 1 Moca -0.032370527 -0.082477132 0.01773608
## 2 UDS-EF Composite 0.060091450 0.011173949 0.10900895
## 3 Trail B Ratio 0.006456274 -0.038723566 0.05163611
## 4 Trail A Ratio 0.001963461 -0.044979193 0.04890612
## 5 DS fwd 0.012436065 -0.024259314 0.04913145
## 6 DS bwd 0.003304911 -0.036789537 0.04339936
## 7 MINT 0.062254447 0.019015031 0.10549386
## 8 Animals 0.041218360 -0.005887952 0.08832467
## 9 Veg 0.036020316 -0.008164354 0.08020499
## 10 Words (F) 0.032217659 -0.009624656 0.07405997
## 11 Words (L) 0.049608021 0.007858323 0.09135772
## 12 Benson Copy -0.129917592 -0.164951907 -0.09488328
## 13 Benson Recall -0.012151499 -0.053542330 0.02923933
## 14 Craft Immed. 0.033142882 -0.007268527 0.07355429
## 15 Craft Delay 0.037291873 -0.004103526 0.07868727
## [1] "#-----------------------#"
## frontal_roi Estimate CI.low CI.high
## 1 Moca 0.047384487 0.035645592 0.05912338
## 2 UDS-EF Composite 0.050145553 0.038667753 0.06162335
## 3 Trail B Ratio 0.036330094 0.025632610 0.04702758
## 4 Trail A Ratio 0.034431054 0.023636658 0.04522545
## 5 DS fwd 0.013434745 0.004675879 0.02219361
## 6 DS bwd 0.027714415 0.018274134 0.03715470
## 7 MINT 0.002877006 -0.007609716 0.01336373
## 8 Animals 0.033755220 0.022783938 0.04472650
## 9 Veg 0.030775688 0.020493861 0.04105751
## 10 Words (F) 0.028153803 0.018303644 0.03800396
## 11 Words (L) 0.029570402 0.019735551 0.03940525
## 12 Benson Copy 0.013603875 0.004949606 0.02225814
## 13 Benson Recall 0.019922731 0.009835768 0.03000969
## 14 Craft Immed. 0.020289540 0.010673986 0.02990509
## 15 Craft Delay 0.024818596 0.014934877 0.03470232
## parietal_roi Estimate CI.low CI.high
## 1 Moca 0.041230832 0.030503821 0.05195784
## 2 UDS-EF Composite 0.039128156 0.028610269 0.04964604
## 3 Trail B Ratio 0.036057596 0.026336979 0.04577821
## 4 Trail A Ratio 0.034398840 0.024332506 0.04446518
## 5 DS fwd 0.010020866 0.002095794 0.01794594
## 6 DS bwd 0.020475748 0.011878967 0.02907253
## 7 MINT 0.002237787 -0.007379613 0.01185519
## 8 Animals 0.023632090 0.013588301 0.03367588
## 9 Veg 0.029120195 0.019695123 0.03854527
## 10 Words (F) 0.019597537 0.010555654 0.02863942
## 11 Words (L) 0.022033475 0.012992054 0.03107490
## 12 Benson Copy 0.022325245 0.014462077 0.03018841
## 13 Benson Recall 0.017169016 0.008001983 0.02633605
## 14 Craft Immed. 0.011255802 0.002423439 0.02008816
## 15 Craft Delay 0.013769623 0.004681534 0.02285771
## temporal_roi Estimate CI.low CI.high
## 1 Moca 0.061044556 0.0491884499 0.072900662
## 2 UDS-EF Composite 0.044269002 0.0326135695 0.055924434
## 3 Trail B Ratio 0.027143765 0.0161901334 0.038097397
## 4 Trail A Ratio 0.030617107 0.0191950879 0.042039125
## 5 DS fwd 0.009817508 0.0009681294 0.018666886
## 6 DS bwd 0.010385374 0.0008105986 0.019960149
## 7 MINT 0.053530392 0.0429539524 0.064106832
## 8 Animals 0.040970231 0.0298854704 0.052054991
## 9 Veg 0.045763517 0.0354560325 0.056071001
## 10 Words (F) 0.022572407 0.0125813593 0.032563455
## 11 Words (L) 0.026839659 0.0168313977 0.036847920
## 12 Benson Copy -0.002530935 -0.0113562975 0.006294428
## 13 Benson Recall 0.032734212 0.0225739840 0.042894441
## 14 Craft Immed. 0.033592388 0.0239029230 0.043281852
## 15 Craft Delay 0.036043530 0.0261199357 0.045967125
## occipital_roi Estimate CI.low CI.high
## 1 Moca 0.035932118 0.0241989613 0.04766527
## 2 UDS-EF Composite 0.037702726 0.0262346424 0.04917081
## 3 Trail B Ratio 0.033010239 0.0222161742 0.04380430
## 4 Trail A Ratio 0.041288401 0.0298956501 0.05268115
## 5 DS fwd 0.009751751 0.0010952989 0.01840820
## 6 DS bwd 0.017297640 0.0078463672 0.02674891
## 7 MINT 0.004629833 -0.0063174448 0.01557711
## 8 Animals 0.019125375 0.0080984136 0.03015234
## 9 Veg 0.027324146 0.0170195241 0.03762877
## 10 Words (F) 0.022412270 0.0125374397 0.03228710
## 11 Words (L) 0.021902702 0.0119974815 0.03180792
## 12 Benson Copy 0.016096781 0.0074963440 0.02469722
## 13 Benson Recall 0.013275320 0.0032396429 0.02331100
## 14 Craft Immed. 0.010638602 0.0009502981 0.02032691
## 15 Craft Delay 0.010745866 0.0007596902 0.02073204
## nfl3_mean_log Estimate CI.low CI.high
## 1 Moca -0.20504498 -0.26560225 -0.144487708
## 2 UDS-EF Composite -0.37910222 -0.43437512 -0.323829332
## 3 Trail B Ratio -0.20686145 -0.25738251 -0.156340390
## 4 Trail A Ratio -0.19823716 -0.25074063 -0.145733681
## 5 DS fwd -0.10049679 -0.14461091 -0.056382670
## 6 DS bwd -0.15939027 -0.20550293 -0.113277601
## 7 MINT -0.13461911 -0.19144525 -0.077792970
## 8 Animals -0.29956943 -0.35349015 -0.245648700
## 9 Veg -0.22742706 -0.27895809 -0.175896033
## 10 Words (F) -0.24215226 -0.29010485 -0.194199675
## 11 Words (L) -0.27916909 -0.32641200 -0.231926187
## 12 Benson Copy -0.04944736 -0.09250113 -0.006393603
## 13 Benson Recall -0.06774707 -0.11819820 -0.017295942
## 14 Craft Immed. -0.11995189 -0.16886572 -0.071038050
## 15 Craft Delay -0.11446377 -0.16481554 -0.064112011UDS early detection
Presents the ability of each task to discriminate between mutation carriers and non-carriers, in a sample with FTLD CDR global = 0. Negative coefficients suggest lower performance in carriers.
## [1] 379 1847
##
## C9 GRN MAPT none
## 79 48 33 219
## c9vsnone Estimate CI.low CI.high
## 1 Moca -0.12149082 -0.3787379 0.13575625
## 2 UDS-EF Composite -0.18493217 -0.4306005 0.06073616
## 3 Trail B Ratio -0.23511479 -0.4810810 0.01085142
## 4 Trail A Ratio -0.22154406 -0.4636075 0.02051942
## 5 DS fwd -0.02394200 -0.2871070 0.23922295
## 6 DS bwd -0.05598279 -0.3162760 0.20431041
## 7 MINT -0.14719408 -0.4257722 0.13138401
## 8 Animals -0.29309872 -0.5500772 -0.03612028
## 9 Veg -0.30366782 -0.5695066 -0.03782901
## 10 Words (F) -0.05665932 -0.3101677 0.19684905
## 11 Words (L) 0.01639177 -0.2476744 0.28045794
## 12 Benson Copy -0.32701316 -0.5993875 -0.05463878
## 13 Benson Recall -0.25178057 -0.5194882 0.01592709
## 14 Craft Immed. -0.09001340 -0.3649260 0.18489919
## 15 Craft Delay -0.16655184 -0.4406703 0.10756660
## grnvsnone Estimate CI.low CI.high
## 1 Moca -0.022178193 -0.33459294 0.29023655
## 2 UDS-EF Composite -0.061182969 -0.36744797 0.24508203
## 3 Trail B Ratio -0.140023124 -0.43715459 0.15710834
## 4 Trail A Ratio -0.264963640 -0.55706020 0.02713292
## 5 DS fwd -0.127916901 -0.43932259 0.18348879
## 6 DS bwd 0.029154780 -0.28237005 0.34067961
## 7 MINT -0.005495055 -0.35639815 0.34540804
## 8 Animals -0.099192002 -0.42023201 0.22184801
## 9 Veg 0.189863513 -0.12552680 0.50525382
## 10 Words (F) 0.287872284 -0.03113745 0.60688202
## 11 Words (L) -0.024356551 -0.34020843 0.29149533
## 12 Benson Copy -0.104823282 -0.42159806 0.21195150
## 13 Benson Recall -0.137489813 -0.46036774 0.18538811
## 14 Craft Immed. -0.258101143 -0.57450014 0.05829785
## 15 Craft Delay -0.190830839 -0.50833793 0.12667625
## maptvsnone Estimate CI.low CI.high
## 1 Moca -0.022178193 -0.33459294 0.29023655
## 2 UDS-EF Composite -0.061182969 -0.36744797 0.24508203
## 3 Trail B Ratio -0.140023124 -0.43715459 0.15710834
## 4 Trail A Ratio -0.264963640 -0.55706020 0.02713292
## 5 DS fwd -0.127916901 -0.43932259 0.18348879
## 6 DS bwd 0.029154780 -0.28237005 0.34067961
## 7 MINT -0.005495055 -0.35639815 0.34540804
## 8 Animals -0.099192002 -0.42023201 0.22184801
## 9 Veg 0.189863513 -0.12552680 0.50525382
## 10 Words (F) 0.287872284 -0.03113745 0.60688202
## 11 Words (L) -0.024356551 -0.34020843 0.29149533
## 12 Benson Copy -0.104823282 -0.42159806 0.21195150
## 13 Benson Recall -0.137489813 -0.46036774 0.18538811
## 14 Craft Immed. -0.258101143 -0.57450014 0.05829785
## 15 Craft Delay -0.190830839 -0.50833793 0.12667625
##
## 0 1
## 9 160
##
## Descriptive statistics by group
## group: 0
## vars n mean sd median trimmed mad min max range skew kurtosis se
## X1 1 7 -0.37 1.1 -0.57 -0.37 0.61 -1.93 1.2 3.13 0.21 -1.51 0.41
## ------------------------------------------------------------
## group: 1
## vars n mean sd median trimmed mad min max range skew kurtosis se
## X1 1 154 0.12 0.75 0.11 0.13 0.79 -1.89 2.13 4.02 -0.11 0.14 0.06
## mut_vs_famcont Estimate CI.low CI.high
## 1 Moca -0.04425983 -0.16848983 0.07997017
## 2 UDS-EF Composite 0.08862596 -0.06098143 0.23823335
## 3 Trail B Ratio -0.01144449 -0.16716256 0.14427358
## 4 Trail A Ratio 0.04074652 -0.09759640 0.17908945
## 5 DS fwd 0.08910548 -0.05763383 0.23584480
## 6 DS bwd 0.10641248 -0.03568258 0.24850753
## 7 MINT -0.02699277 -0.17423145 0.12024590
## 8 Animals -0.04142803 -0.20052178 0.11766572
## 9 Veg 0.04036607 -0.12328160 0.20401374
## 10 Words (F) 0.07676849 -0.05698396 0.21052093
## 11 Words (L) 0.01431016 -0.12786207 0.15648239
## 12 Benson Copy -0.01118691 -0.14823786 0.12586404
## 13 Benson Recall -0.09403601 -0.23625133 0.04817930
## 14 Craft Immed. -0.06060082 -0.20209390 0.08089225
## 15 Craft Delay -0.16843922 -0.30846691 -0.02841153UDS Power Analysis: Mutation and CDR
First, the forest plots present the average change per year in Z score units. The second plot presents the number of participants needed to detect a 25% (square) and 40 % (target) drug effect using each measure. Each tab presents a different subsample. All participants have CDR+NACC-FTLD Global Scores > 0.
Mutation Positive
##
## C9 GRN MAPT
## 72 34 39MAPT Carriers
The sample was limited to those with a CDR+NACC-FTLD Global Score >0 and with a MAPT mutation.
##
## MAPT
## 35C9 Carriers
The sample was limited to those with a CDR+NACC-FTLD Global Score >0 and with a C9 mutation.
##
## C9
## 67GRN Carriers
The sample was limited to those with a CDR+NACC-FTLD Global Score >0 and with a GRN mutation.
##
## GRN
## 34UDS Power Analysis by Syndrome
Similar to the power analyses above, I completed power analyses within a specific syndrome.
Sample Description by Syndrome
Presents a description of the sample by syndrome.
| ad | als | bvftd | cbs | cu | dementia with lewy bodies | lvppa | mci | nvppa | other | pd | psp | svppa | p | test | ad | als | bvftd | cbs | cu | dementia with lewy bodies | lvppa | mci | nvppa | other | pd | psp | svppa | p | test | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | 5 | 10 | 218 | 26 | 484 | 1 | 6 | 65 | 38 | 22 | 3 | 16 | 48 | 5 | 10 | 218 | 26 | 484 | 1 | 6 | 65 | 38 | 22 | 3 | 16 | 48 | ||||
| sex = Male (%) | 1 (20.0) | 8 (80.0) | 133 (61.0) | 14 (53.8) | 189 ( 39.0) | 1 (100.0) | 2 (33.3) | 31 ( 47.7) | 16 (42.1) | 10 (45.5) | 2 ( 66.7) | 10 ( 62.5) | 28 ( 58.3) | <0.001 | 1 (20.0) | 8 (80.0) | 133 (61.0) | 14 (53.8) | 189 ( 39.0) | 1 (100.0) | 2 (33.3) | 31 ( 47.7) | 16 (42.1) | 10 (45.5) | 2 ( 66.7) | 10 ( 62.5) | 28 ( 58.3) | <0.001 | ||
| ftldcdr_glob (%) | <0.001 | <0.001 | ||||||||||||||||||||||||||||
| 0 | 0 ( 0.0) | 1 (10.0) | 0 ( 0.0) | 1 ( 3.8) | 484 (100.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 13 (59.1) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 1 (10.0) | 0 ( 0.0) | 1 ( 3.8) | 484 (100.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 13 (59.1) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | ||||
| 0.5 | 1 (20.0) | 2 (20.0) | 26 (11.9) | 9 (34.6) | 0 ( 0.0) | 0 ( 0.0) | 2 (33.3) | 65 (100.0) | 15 (39.5) | 7 (31.8) | 3 (100.0) | 6 ( 37.5) | 14 ( 29.2) | 1 (20.0) | 2 (20.0) | 26 (11.9) | 9 (34.6) | 0 ( 0.0) | 0 ( 0.0) | 2 (33.3) | 65 (100.0) | 15 (39.5) | 7 (31.8) | 3 (100.0) | 6 ( 37.5) | 14 ( 29.2) | ||||
| 1 | 2 (40.0) | 4 (40.0) | 90 (41.3) | 10 (38.5) | 0 ( 0.0) | 0 ( 0.0) | 3 (50.0) | 0 ( 0.0) | 19 (50.0) | 0 ( 0.0) | 0 ( 0.0) | 8 ( 50.0) | 24 ( 50.0) | 2 (40.0) | 4 (40.0) | 90 (41.3) | 10 (38.5) | 0 ( 0.0) | 0 ( 0.0) | 3 (50.0) | 0 ( 0.0) | 19 (50.0) | 0 ( 0.0) | 0 ( 0.0) | 8 ( 50.0) | 24 ( 50.0) | ||||
| 2 | 2 (40.0) | 3 (30.0) | 89 (40.8) | 5 (19.2) | 0 ( 0.0) | 1 (100.0) | 1 (16.7) | 0 ( 0.0) | 3 ( 7.9) | 1 ( 4.5) | 0 ( 0.0) | 1 ( 6.2) | 10 ( 20.8) | 2 (40.0) | 3 (30.0) | 89 (40.8) | 5 (19.2) | 0 ( 0.0) | 1 (100.0) | 1 (16.7) | 0 ( 0.0) | 3 ( 7.9) | 1 ( 4.5) | 0 ( 0.0) | 1 ( 6.2) | 10 ( 20.8) | ||||
| 3 | 0 ( 0.0) | 0 ( 0.0) | 13 ( 6.0) | 1 ( 3.8) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 1 ( 2.6) | 1 ( 4.5) | 0 ( 0.0) | 1 ( 6.2) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 13 ( 6.0) | 1 ( 3.8) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 1 ( 2.6) | 1 ( 4.5) | 0 ( 0.0) | 1 ( 6.2) | 0 ( 0.0) | ||||
| genetic_factor (%) | <0.001 | <0.001 | ||||||||||||||||||||||||||||
| C9 | 0 ( 0.0) | 6 (75.0) | 45 (22.6) | 0 ( 0.0) | 108 ( 24.1) | 0 ( 0.0) | 0 ( 0.0) | 17 ( 27.9) | 2 ( 6.5) | 7 (38.9) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 6 (75.0) | 45 (22.6) | 0 ( 0.0) | 108 ( 24.1) | 0 ( 0.0) | 0 ( 0.0) | 17 ( 27.9) | 2 ( 6.5) | 7 (38.9) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | ||||
| GRN | 2 (50.0) | 0 ( 0.0) | 14 ( 7.0) | 5 (19.2) | 55 ( 12.3) | 0 ( 0.0) | 2 (40.0) | 7 ( 11.5) | 3 ( 9.7) | 4 (22.2) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | 2 (50.0) | 0 ( 0.0) | 14 ( 7.0) | 5 (19.2) | 55 ( 12.3) | 0 ( 0.0) | 2 (40.0) | 7 ( 11.5) | 3 ( 9.7) | 4 (22.2) | 0 ( 0.0) | 0 ( 0.0) | 0 ( 0.0) | ||||
| MAPT | 2 (50.0) | 0 ( 0.0) | 26 (13.1) | 1 ( 3.8) | 56 ( 12.5) | 0 ( 0.0) | 0 ( 0.0) | 8 ( 13.1) | 0 ( 0.0) | 2 (11.1) | 2 ( 66.7) | 0 ( 0.0) | 0 ( 0.0) | 2 (50.0) | 0 ( 0.0) | 26 (13.1) | 1 ( 3.8) | 56 ( 12.5) | 0 ( 0.0) | 0 ( 0.0) | 8 ( 13.1) | 0 ( 0.0) | 2 (11.1) | 2 ( 66.7) | 0 ( 0.0) | 0 ( 0.0) | ||||
| none | 0 ( 0.0) | 2 (25.0) | 114 (57.3) | 20 (76.9) | 229 ( 51.1) | 1 (100.0) | 3 (60.0) | 29 ( 47.5) | 26 (83.9) | 5 (27.8) | 1 ( 33.3) | 13 (100.0) | 42 (100.0) | 0 ( 0.0) | 2 (25.0) | 114 (57.3) | 20 (76.9) | 229 ( 51.1) | 1 (100.0) | 3 (60.0) | 29 ( 47.5) | 26 (83.9) | 5 (27.8) | 1 ( 33.3) | 13 (100.0) | 42 (100.0) |
| Overall | ad | als | bvftd | cbs | cu | dementia with lewy bodies | lvppa | mci | nvppa | other | pd | psp | svppa | p | test | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | 971 | 5 | 10 | 218 | 26 | 484 | 1 | 6 | 65 | 38 | 22 | 3 | 16 | 48 | ||
| moca_total (mean (SD)) | 24.04 (6.06) | 21.80 (3.96) | 22.90 (3.63) | 19.17 (6.88) | 17.81 (6.83) | 27.31 (2.29) | 20.00 (NA) | 13.40 (7.77) | 25.42 (3.13) | 20.71 (6.19) | 26.56 (4.71) | 23.33 (2.08) | 20.64 (5.90) | 15.87 (6.67) | NA | |
| uds3_ef (mean (SD)) | -0.63 (1.34) | -1.12 (1.18) | -1.71 (0.87) | -1.79 (1.20) | -2.14 (1.19) | 0.21 (0.73) | -1.61 (NA) | -1.79 (0.96) | -0.52 (0.83) | -1.98 (0.89) | 0.09 (1.06) | -1.32 (0.97) | -2.58 (1.15) | -2.03 (0.90) | NA | |
| traila_ratio (mean (SD)) | 0.92 (0.42) | 0.79 (0.20) | 0.44 (0.20) | 0.61 (0.29) | 0.45 (0.26) | 1.13 (0.36) | 0.51 (NA) | 0.60 (0.18) | 0.89 (0.31) | 0.58 (0.25) | 1.09 (0.45) | 0.55 (0.36) | 0.35 (0.19) | 0.65 (0.31) | NA | |
| trailb_ratio (mean (SD)) | 0.38 (0.19) | 0.22 (0.16) | 0.18 (0.13) | 0.24 (0.14) | 0.15 (0.14) | 0.48 (0.16) | 0.20 (NA) | 0.15 (0.08) | 0.35 (0.14) | 0.20 (0.10) | 0.42 (0.17) | 0.27 (0.12) | 0.14 (0.11) | 0.24 (0.13) | NA | |
| dig_fwd_sum (mean (SD)) | 8.05 (2.66) | 8.75 (2.22) | 6.60 (1.78) | 6.85 (2.55) | 5.68 (2.36) | 8.96 (2.33) | 7.00 (NA) | 4.75 (2.22) | 8.31 (2.18) | 4.88 (2.24) | 9.44 (2.64) | 8.33 (1.53) | 7.14 (2.80) | 6.93 (2.58) | NA | |
| dig_back_sum (mean (SD)) | 6.59 (2.80) | 7.25 (2.06) | 5.40 (1.43) | 4.85 (2.66) | 3.82 (2.40) | 7.76 (2.30) | 4.00 (NA) | 3.25 (1.50) | 6.71 (2.26) | 4.09 (2.18) | 8.17 (2.01) | 5.33 (2.31) | 3.50 (2.71) | 5.64 (2.84) | NA | |
| mint_total (mean (SD)) | 24.89 (7.67) | 14.50 (10.61) | 24.00 (6.08) | 23.44 (7.69) | 23.11 (8.56) | 28.50 (1.57) | 29.00 (NA) | 22.00 (10.23) | 26.67 (3.41) | 25.18 (6.59) | 25.78 (9.05) | 28.00 (2.00) | 26.56 (4.50) | 7.98 (8.42) | NA | |
| flu_animal (mean (SD)) | 19.24 (8.18) | 17.60 (11.84) | 14.70 (5.23) | 13.43 (7.39) | 11.86 (7.66) | 23.57 (5.60) | 17.00 (NA) | 15.50 (5.92) | 20.40 (6.61) | 12.03 (5.79) | 22.00 (7.77) | 18.00 (5.29) | 11.57 (5.80) | 8.02 (5.23) | NA | |
| flu_veg (mean (SD)) | 12.26 (5.80) | 11.25 (8.10) | 8.67 (4.00) | 7.97 (5.16) | 7.91 (5.85) | 15.31 (4.17) | 6.00 (NA) | 9.00 (2.58) | 12.58 (3.63) | 8.40 (4.43) | 14.78 (4.89) | 10.33 (5.51) | 7.50 (4.50) | 4.07 (4.24) | NA | |
| flu_fwords (mean (SD)) | 12.37 (5.90) | 9.60 (3.85) | 9.70 (3.59) | 8.34 (5.27) | 7.64 (4.91) | 15.23 (4.72) | 6.00 (NA) | 9.25 (3.77) | 12.97 (4.04) | 6.63 (4.00) | 15.56 (4.73) | 8.67 (6.03) | 4.86 (4.87) | 7.33 (4.68) | NA | |
| flu_lwords (mean (SD)) | 11.69 (5.61) | 12.60 (6.35) | 8.50 (3.60) | 7.71 (5.10) | 7.55 (5.47) | 14.33 (4.44) | 8.00 (NA) | 9.25 (5.19) | 12.00 (3.88) | 6.48 (3.95) | 15.28 (4.85) | 9.33 (5.86) | 5.86 (4.74) | 7.10 (4.51) | NA | |
| benson_copy (mean (SD)) | 15.07 (2.41) | 16.60 (0.55) | 13.30 (3.40) | 14.47 (2.88) | 11.11 (5.70) | 15.64 (1.27) | 15.00 (NA) | 13.00 (6.06) | 15.27 (1.46) | 14.00 (4.11) | 16.06 (1.30) | 14.67 (0.58) | 11.00 (3.96) | 15.00 (1.96) | NA | |
| benson_delay (mean (SD)) | 10.81 (4.24) | 6.40 (4.04) | 9.44 (4.07) | 7.70 (4.72) | 7.00 (4.68) | 12.67 (2.59) | 12.00 (NA) | 6.75 (4.57) | 10.97 (3.34) | 10.31 (4.64) | 13.61 (2.35) | 10.67 (3.21) | 7.86 (3.68) | 6.78 (5.17) | NA | |
| craft_v_immed (mean (SD)) | 18.81 (8.74) | 15.00 (8.41) | 16.70 (8.73) | 13.38 (8.36) | 14.10 (8.62) | 22.64 (6.56) | 22.00 (NA) | 8.00 (2.16) | 20.92 (7.24) | 13.61 (8.30) | 20.67 (8.25) | 11.33 (4.04) | 15.93 (8.39) | 6.93 (6.83) | NA | |
| craft_v_delay (mean (SD)) | 16.28 (8.81) | 10.75 (9.36) | 14.44 (7.50) | 9.66 (7.75) | 12.05 (9.28) | 20.44 (6.69) | 18.00 (NA) | 8.75 (4.99) | 17.82 (7.94) | 11.10 (7.63) | 18.72 (7.75) | 8.00 (2.65) | 13.64 (7.59) | 5.91 (6.81) | NA |
Cognitively Unimpaired
Presents a power analysis within the cognitively unimpaired cohort.
bvFTD
Presents a power analysis within the bvFTD cohort.
CBS
Presents a power analysis within the CBS cohort.
MCI (removed)
## [1] "Analyses are not displayed due to the low effect size within this group. All measures require >500 participants."nvPPA
Presents a power analysis within the nvPPA cohort.
PSP
Presents a power analysis within the PSP cohort.
svPPA
Presents a power analysis within the svPPA cohort.
AD+lvPPA
Presents a power analysis within a cohort that included those diagnosed with AD and/or lvPPA.
Missigness TabCAT
We have a fair amount of missing data for TabCAT tasks, particularly in longitudinal analyses. There are several systematic reasons for this including the pandemic, bugs, and lack of administration to folks who are more impaired. Missingness is notably high in folks with higher CDR+NACC-FTLD global scores. Additionally, some folks failed practice trials for several TabCAT tasks. To investigate the impact of failed practice trials I did 2 analyses: 1) grouped participants by failure of any practice trial vs passed all practice trials; 2) examined how failure of a practice trial impacted missingness on that specific task (running dots, set shifting, match, flanker).
1. Failure of even a single practice trial is associated with missingness on all TabCAT-EXAMINER tasks, including the fluency items. This appears to be linked primary to folks with higher CDRS (not in markdown).
2. Failure on the practice trial accounts for the majority of missingness in those administered the task.
Missigness TabCAT-EXAMINER by FTLD CDR Global
###### There is clearly an increase in missingness as you increase in CDR. It does look like Match was given to folks even with higher CDR and its missingness is similar to that of the fluency variables.
###TabCAT-EXAMINER Missigness by syndrome ######
Missingness TabCAT-EXAMINER by pass/fail
Failure of a single task noteably increases missingness.
Missigness TabCAT-EXAMINER for individual tasks
| Variable | NA overall | NA practice fail | % NA that failed practice |
|---|---|---|---|
| setshift | 86 | 63 | 73.26 |
| match | 38 | 0 | 0 |
| flanker | 130 | 104 | 80 |
| rundots | 235 | 135 | 57.45 |
TabCAT-EXAMINER Forest Plots (Regressions)
Similar to above, this section presents associations between each TabCAT task and the FTLD CDR Sum of Boxes, controlling for age, sex, and education. I then included associations between each cognitive measure and several scales: PSPRS, UPDRS, ALSFRS, NPI, FAQ, SNQ, SBOC, IRI, RSMS. This analysis differs from the one above (UDS Forest Plots) because this sample is slightly different. It is restricted to those who recieved TabCAT, meaning there are generally less impaired participants.
Note, there are two TabCAT-EXAMINER scores. Both are based on the same model. The TabCAT-EXAMINER (NA Flunecy) had all flunecy items set to NA before creation of individual factor scores.
## [1] "#-----------------------#"
## [1] "current cleaning matrix:"
## Variable_names
## education "educ,education,years_education,edu"
## flu_animal "animals,animal_fluency_total_correct,animalfluency_totalcorrect"
## flu_veg "veg"
## flu_fwords "udsverfc,fwords,UDSVERFC"
## flu_lwords "udsverlc,lwords,UDSVERLC"
## trails_a "traila"
## trails_b "trailb"
## dspan_fwd_length "digfwd_length,digforsl,digitfw_ucl"
## dspan_bck_length "digbwd_length,digbacls,digitbw_ucl"
## benson_delay "udsbentd"
## benson_copy "udsbentc,benson_temp"
## craft_v_delay "craftdvr"
## craft_v_immed "craftvrs"
## moca_total "mocatots,mocatotwitheduc"
## mmse_total "mmsetot,mmse_temp"
## mint_total "minttots"
## tabcat_match "match_totalcorrect,match_total_correct"
## tabcat_rundots "runningdots_totalcorrect,running_dots_trial_score"
## tabcat_dotcount "dotcounting_totalscore,dot_counting_total_score"
## tabcat_flanker "flanker_totalscore"
## tabcat_setshift "setshifting_totalscore,set_shifting_total_score"
## tabcat_favorite "favorites_alltrials_totalcorrect,favorites_all_trials_total_correct"
## tabcat_lineo "lo_thresholdscore_3.10,lo_threshold_score_3_10"
## cdr_sob "cdrsum,cdrbox"
## cdr_global "cdrglob,cdr global"
## ftldcdr_sob "ftldcdr_sb,ftld-cdr box,ftldcdr_sob,ftldcdrsob,ftldcdr_box,ftldcdr_sb,ftldcdrbox"
## ftldcdr_global "ftldcdr_glob,ftld-cdr global,ftldcdr_global,ftldcdrglobal,ftldcdrglob"
## cvltsf_tot_immed "trcotot,total_cvlt_temp"
## cvltsf_delay "corr10,cvsltsf_10_temp,cvlt_10min_correct"
## bnt15_corr "bntcorr_bedside"
## bnt30_corr "boston_uds,bnt_30"
## stroop_cn_bedside "strpcncor_bedside"
## stroop_inhib_bedside "strpcor_bedside"
## log_mem_immed "logimem"
## Log_mem_delay "MEMTIME,memtime"
## dig_fwd_sum "digforct"
## dig_back_sum "digbacct"
## df_corr "dfcor_temp"
## npi_total "npi_qtotal"
## faq_total "faqtotal"
## snq_total "ftdsntot"
## sboc_desc_total "ftdsbtot"
## sboc_behav_total "ftdsbcto"
## iri_emp "ftdiriec"
## iri_pt "ftdiript"
## rsms_sen "ftdsmscr"
## rsms_selfpre "ftdspscr"
## rsms_total "ftdrsmst"
## updrs_totalcln "updrs_score"
## psprs_totalcln "psprs_total"
## alsfrs_total "alsfrs_sum"
## Min Max Set to floor Set to ceiling Exclude
## education "0" "30" "NONE/NA" "NONE/NA" NA
## flu_animal "0" "60" "NONE/NA" "NONE/NA" NA
## flu_veg "0" "60" "NONE/NA" "NONE/NA" NA
## flu_fwords "0" "60" "NONE/NA" "NONE/NA" NA
## flu_lwords "0" "60" "NONE/NA" "NONE/NA" NA
## trails_a "0" "150" "NONE/NA" "NONE/NA" NA
## trails_b "0" "300" "NONE/NA" "NONE/NA" NA
## dspan_fwd_length "0" "10" "NONE/NA" "NONE/NA" NA
## dspan_bck_length "0" "10" "NONE/NA" "NONE/NA" NA
## benson_delay "0" "17" "NONE/NA" "NONE/NA" NA
## benson_copy "0" "17" "NONE/NA" "NONE/NA" NA
## craft_v_delay "0" "40" "NONE/NA" "NONE/NA" NA
## craft_v_immed "0" "40" "NONE/NA" "NONE/NA" NA
## moca_total "0" "30" "NONE/NA" "NONE/NA" NA
## mmse_total "0" "30" "NONE/NA" "NONE/NA" NA
## mint_total "0" "30" "NONE/NA" "NONE/NA" NA
## tabcat_match "0" "90" "NONE/NA" "NONE/NA" NA
## tabcat_rundots "0" "42" "NONE/NA" "NONE/NA" NA
## tabcat_dotcount "0" "27" "NONE/NA" "NONE/NA" NA
## tabcat_flanker "0" "11" "NONE/NA" "NONE/NA" NA
## tabcat_setshift "0" "11" "NONE/NA" "NONE/NA" NA
## tabcat_favorite "0" "24" "NONE/NA" "NONE/NA" NA
## tabcat_lineo "1" "50" "NONE/NA" "NONE/NA" NA
## cdr_sob "0" "18" "NONE/NA" "NONE/NA" NA
## cdr_global "0" "3" "NONE/NA" "NONE/NA" NA
## ftldcdr_sob "0" "24" "NONE/NA" "NONE/NA" NA
## ftldcdr_global "0" "3" "NONE/NA" "NONE/NA" NA
## cvltsf_tot_immed "0" "36" "NONE/NA" "NONE/NA" NA
## cvltsf_delay "0" "9" "NONE/NA" "NONE/NA" NA
## bnt15_corr "0" "15" "NONE/NA" "NONE/NA" NA
## bnt30_corr "0" "30" "NONE/NA" "NONE/NA" NA
## stroop_cn_bedside "0" "150" "NONE/NA" "NONE/NA" NA
## stroop_inhib_bedside "0" "100" "NONE/NA" "NONE/NA" NA
## log_mem_immed "0" "50" "NONE/NA" "NONE/NA" NA
## Log_mem_delay "0" "50" "NONE/NA" "NONE/NA" NA
## dig_fwd_sum "0" "16" "NONE/NA" "NONE/NA" NA
## dig_back_sum "0" "16" "NONE/NA" "NONE/NA" NA
## df_corr "0" "50" "NONE/NA" "NONE/NA" NA
## npi_total "0" "55" "NONE/NA" "NONE/NA" NA
## faq_total "0" "30" "NONE/NA" "NONE/NA" NA
## snq_total "0" "22" "NONE/NA" "NONE/NA" NA
## sboc_desc_total "0" "42" "NONE/NA" "NONE/NA" NA
## sboc_behav_total "0" "105" "NONE/NA" "NONE/NA" NA
## iri_emp "7" "35" "NONE/NA" "NONE/NA" NA
## iri_pt "7" "35" "NONE/NA" "NONE/NA" NA
## rsms_sen "0" "30" "NONE/NA" "NONE/NA" NA
## rsms_selfpre "0" "35" "NONE/NA" "NONE/NA" NA
## rsms_total "0" "65" "NONE/NA" "NONE/NA" NA
## updrs_totalcln "0" "80" "NONE/NA" "NONE/NA" NA
## psprs_totalcln "0" "77" "NONE/NA" "NONE/NA" NA
## alsfrs_total "6" "48" "NONE/NA" "NONE/NA" NA
## [1] "-------------------------------------------------------"
## [1] "Cleaned the following variables:"
## [1] "educ" "animals"
## [3] "veg" "udsverfc"
## [5] "fwords" "udsverlc"
## [7] "lwords" "traila"
## [9] "trailb" "digfwd_length"
## [11] "digforsl" "digbwd_length"
## [13] "digbacls" "udsbentd"
## [15] "udsbentc" "craftdvr"
## [17] "craftvrs" "mocatots"
## [19] "minttots" "match_totalcorrect"
## [21] "runningdots_totalcorrect" "dotcounting_totalscore"
## [23] "flanker_totalscore" "setshifting_totalscore"
## [25] "favorites_alltrials_totalcorrect" "lo_thresholdscore_3.10"
## [27] "cdrsum" "cdrglob"
## [29] "ftldcdr_sb" "ftldcdr_sb"
## [31] "ftldcdr_glob" "cvlt_10min_correct"
## [33] "digforct" "digbacct"
## [35] "npi_qtotal" "faqtotal"
## [37] "ftdsntot" "ftdsbtot"
## [39] "ftdsbcto" "ftdiriec"
## [41] "ftdiript" "ftdsmscr"
## [43] "ftdspscr" "ftdrsmst"
## [45] "updrs_score" "psprs_total"
## [47] "alsfrs_sum"
## [1] "-------------------------------------------------------"
## ftldcdr_sb Estimate CI.low CI.high
## 1 Moca -0.6647272 -0.7144357 -0.6150187
## 2 TabCAT-Examiner -0.7093748 -0.7701217 -0.6486279
## 3 TabCAT-Examiner (NA-Fluency) -0.2956091 -0.3535781 -0.2376402
## 4 UDS3-EF -0.6380850 -0.6961590 -0.5800110
## 5 Trail B Ratio -0.3936217 -0.4602815 -0.3269620
## 6 Trail A Ratio -0.3959624 -0.4559843 -0.3359404
## 7 DS fwd -0.2508691 -0.3148776 -0.1868606
## 8 DS bwd -0.4108230 -0.4701970 -0.3514490
## 9 MINT -0.3223988 -0.4132740 -0.2315237
## 10 Animals -0.5547486 -0.6136412 -0.4958559
## 11 Veg -0.4400391 -0.4983526 -0.3817256
## 12 Words (F) -0.4787229 -0.5378810 -0.4195648
## 13 Words (L) -0.4394918 -0.4982605 -0.3807230
## 14 Benson Copy -0.2515021 -0.3126600 -0.1903442
## 15 Benson Recall -0.5284219 -0.5863230 -0.4705207
## 16 Craft Immed. -0.4810303 -0.5397965 -0.4222641
## 17 Craft Delay -0.4934083 -0.5530337 -0.4337830
## [1] "#-----------------------#"
## psprs_total Estimate CI.low CI.high
## 1 Moca -0.13529763 -0.23304431 -0.03755095
## 2 TabCAT-Examiner -0.45165079 -0.55485563 -0.34844596
## 3 TabCAT-Examiner (NA-Fluency) -0.23361176 -0.30470214 -0.16252137
## 4 UDS3-EF -0.40233966 -0.49489875 -0.30978057
## 5 Trail B Ratio -0.28034705 -0.36393912 -0.19675498
## 6 Trail A Ratio -0.19726073 -0.26842824 -0.12609323
## 7 DS fwd -0.13546789 -0.20612064 -0.06481515
## 8 DS bwd -0.22284334 -0.29686809 -0.14881859
## 9 MINT 0.13459691 0.03062431 0.23856951
## 10 Animals -0.18316481 -0.27190409 -0.09442553
## 11 Veg -0.16384535 -0.24466631 -0.08302439
## 12 Words (F) -0.22724794 -0.30619938 -0.14829649
## 13 Words (L) -0.20666423 -0.28266022 -0.13066823
## 14 Benson Copy -0.30815698 -0.37413771 -0.24217624
## 15 Benson Recall -0.05494981 -0.13737472 0.02747510
## 16 Craft Immed. -0.05195546 -0.13576131 0.03185038
## 17 Craft Delay -0.03334026 -0.11975766 0.05307714
## updrs_score Estimate CI.low CI.high
## 1 Moca -0.15189269 -0.25362183 -0.05016354
## 2 TabCAT-Examiner -0.46103838 -0.56731648 -0.35476029
## 3 TabCAT-Examiner (NA-Fluency) -0.25983592 -0.32851433 -0.19115751
## 4 UDS3-EF -0.40375195 -0.49952931 -0.30797459
## 5 Trail B Ratio -0.28985131 -0.37295412 -0.20674851
## 6 Trail A Ratio -0.21729441 -0.28748263 -0.14710619
## 7 DS fwd -0.13503142 -0.20835571 -0.06170712
## 8 DS bwd -0.23635769 -0.31328142 -0.15943396
## 9 MINT 0.12325385 0.01375868 0.23274902
## 10 Animals -0.18197143 -0.27361957 -0.09032329
## 11 Veg -0.15162793 -0.23413497 -0.06912089
## 12 Words (F) -0.22335596 -0.30406574 -0.14264618
## 13 Words (L) -0.19761974 -0.27515067 -0.12008882
## 14 Benson Copy -0.30985655 -0.37969381 -0.24001928
## 15 Benson Recall -0.05072723 -0.13340720 0.03195274
## 16 Craft Immed. -0.07257001 -0.15825390 0.01311387
## 17 Craft Delay -0.05599559 -0.14380582 0.03181464
## alsfrs_sum Estimate CI.low CI.high
## 1 Moca 8.227529e-02 -0.023275343 0.187825927
## 2 TabCAT-Examiner 3.659606e-01 0.251142822 0.480778453
## 3 TabCAT-Examiner (NA-Fluency) 1.692601e-01 0.085391799 0.253128372
## 4 UDS3-EF 3.271174e-01 0.224200051 0.430034813
## 5 Trail B Ratio 2.425922e-01 0.151928921 0.333255443
## 6 Trail A Ratio 2.156434e-01 0.126373591 0.304913204
## 7 DS fwd 1.143940e-01 0.036950285 0.191837699
## 8 DS bwd 2.138794e-01 0.132390315 0.295368407
## 9 MINT -1.134510e-01 -0.230697572 0.003795595
## 10 Animals 1.138428e-01 0.017209404 0.210476203
## 11 Veg 9.782177e-02 0.009269547 0.186373990
## 12 Words (F) 1.827120e-01 0.096603792 0.268820133
## 13 Words (L) 1.882289e-01 0.106354566 0.270103164
## 14 Benson Copy 3.505398e-01 0.279951806 0.421127724
## 15 Benson Recall 5.554799e-06 -0.090384798 0.090395907
## 16 Craft Immed. 2.267774e-02 -0.066108830 0.111464314
## 17 Craft Delay 4.485886e-03 -0.087792766 0.096764537
## [1] "#-----------------------#"
## npi_total Estimate CI.low CI.high
## 1 Moca 0.134412147 0.05067772 0.218146577
## 2 TabCAT-Examiner 0.032526216 -0.05897928 0.124031716
## 3 TabCAT-Examiner (NA-Fluency) -0.006627365 -0.08537745 0.072122719
## 4 UDS3-EF 0.047269828 -0.03697607 0.131515728
## 5 Trail B Ratio 0.023465935 -0.04936717 0.096299040
## 6 Trail A Ratio 0.006806399 -0.06598132 0.079594120
## 7 DS fwd 0.043619373 -0.01704988 0.104288628
## 8 DS bwd 0.042300931 -0.02413753 0.108739388
## 9 MINT 0.126706820 0.04166088 0.211752756
## 10 Animals 0.052639713 -0.02533899 0.130618411
## 11 Veg 0.011271000 -0.05766651 0.080208515
## 12 Words (F) 0.029576352 -0.04125973 0.100412432
## 13 Words (L) 0.030553150 -0.03756024 0.098666540
## 14 Benson Copy 0.042549301 -0.01739896 0.102497565
## 15 Benson Recall -0.008526766 -0.08069849 0.063644957
## 16 Craft Immed. -0.016054075 -0.08763711 0.055528962
## 17 Craft Delay -0.081949364 -0.15445035 -0.009448374
## faq_total Estimate CI.low CI.high
## 1 Moca -0.0894624927 -0.151993390 -0.026931596
## 2 TabCAT-Examiner -0.0866617804 -0.150826701 -0.022496860
## 3 TabCAT-Examiner (NA-Fluency) 0.0084481175 -0.041835312 0.058731547
## 4 UDS3-EF -0.0574758915 -0.116366491 0.001414708
## 5 Trail B Ratio -0.0320875841 -0.079937401 0.015762232
## 6 Trail A Ratio 0.0002233418 -0.044813563 0.045260247
## 7 DS fwd 0.0229169429 -0.018175337 0.064009223
## 8 DS bwd -0.0218133008 -0.066863911 0.023237310
## 9 MINT 0.0764660164 0.004285152 0.148646881
## 10 Animals -0.0393467646 -0.091825773 0.013132244
## 11 Veg -0.0332982990 -0.078569121 0.011972523
## 12 Words (F) -0.0146062941 -0.062773379 0.033560791
## 13 Words (L) -0.0168194086 -0.062160256 0.028521439
## 14 Benson Copy -0.0505689387 -0.090990257 -0.010147620
## 15 Benson Recall -0.0761433533 -0.126629243 -0.025657464
## 16 Craft Immed. -0.0253025698 -0.074510480 0.023905341
## 17 Craft Delay -0.0506032900 -0.100067240 -0.001139340
## snq_total Estimate CI.low CI.high
## 1 Moca 0.48568467 0.395311028 0.5760583
## 2 TabCAT-Examiner 0.41355592 0.317353558 0.5097583
## 3 TabCAT-Examiner (NA-Fluency) 0.10992582 0.025368479 0.1944832
## 4 UDS3-EF 0.40732248 0.319846639 0.4947983
## 5 Trail B Ratio 0.19520669 0.114304327 0.2761091
## 6 Trail A Ratio 0.18420335 0.106074222 0.2623325
## 7 DS fwd 0.23357375 0.167879965 0.2992675
## 8 DS bwd 0.17977827 0.108501387 0.2510552
## 9 MINT 0.29318108 0.191364345 0.3949978
## 10 Animals 0.32109571 0.240161869 0.4020295
## 11 Veg 0.25772903 0.182469024 0.3329890
## 12 Words (F) 0.28723917 0.212272348 0.3622060
## 13 Words (L) 0.27483771 0.202834938 0.3468405
## 14 Benson Copy 0.06239117 -0.003127941 0.1279103
## 15 Benson Recall 0.10960491 0.026931881 0.1922779
## 16 Craft Immed. 0.29490215 0.218610778 0.3711935
## 17 Craft Delay 0.22687667 0.147334738 0.3064186
## sboc_desc_total Estimate CI.low CI.high
## 1 Moca -0.29376591 -0.3804555 -0.207076312
## 2 TabCAT-Examiner -0.22694930 -0.3208256 -0.133072969
## 3 TabCAT-Examiner (NA-Fluency) -0.13955440 -0.2184847 -0.060624091
## 4 UDS3-EF -0.17036894 -0.2575238 -0.083214049
## 5 Trail B Ratio -0.07657046 -0.1544190 0.001278098
## 6 Trail A Ratio -0.13799155 -0.2109386 -0.065044535
## 7 DS fwd -0.09167109 -0.1562252 -0.027116964
## 8 DS bwd -0.05252809 -0.1218546 0.016798420
## 9 MINT -0.08301834 -0.1772055 0.011168828
## 10 Animals -0.14813028 -0.2293134 -0.066947170
## 11 Veg -0.13117158 -0.2034583 -0.058884872
## 12 Words (F) -0.09035528 -0.1642211 -0.016489418
## 13 Words (L) -0.08304127 -0.1536900 -0.012392565
## 14 Benson Copy -0.11685094 -0.1790215 -0.054680374
## 15 Benson Recall -0.20057769 -0.2757298 -0.125425582
## 16 Craft Immed. -0.22555248 -0.2995186 -0.151586329
## 17 Craft Delay -0.20278085 -0.2760907 -0.129470992
## sboc_behav_total Estimate CI.low CI.high
## 1 Moca -0.29004641 -0.3800445 -0.2000483063
## 2 TabCAT-Examiner -0.18835856 -0.2859908 -0.0907263151
## 3 TabCAT-Examiner (NA-Fluency) -0.10776982 -0.1883423 -0.0271973752
## 4 UDS3-EF -0.15038151 -0.2406787 -0.0600843358
## 5 Trail B Ratio -0.05926125 -0.1392336 0.0207111006
## 6 Trail A Ratio -0.09394952 -0.1689719 -0.0189271404
## 7 DS fwd -0.07294403 -0.1398605 -0.0060275195
## 8 DS bwd -0.03356238 -0.1053054 0.0381806203
## 9 MINT -0.14489854 -0.2390881 -0.0507089889
## 10 Animals -0.15437120 -0.2383942 -0.0703482359
## 11 Veg -0.14974125 -0.2230042 -0.0764783051
## 12 Words (F) -0.10138731 -0.1776385 -0.0251361535
## 13 Words (L) -0.07684152 -0.1498879 -0.0037951164
## 14 Benson Copy -0.06511027 -0.1297559 -0.0004646391
## 15 Benson Recall -0.17880897 -0.2572591 -0.1003588219
## 16 Craft Immed. -0.22140692 -0.2979282 -0.1448855957
## 17 Craft Delay -0.20316229 -0.2787094 -0.1276151388
## iri_emp Estimate CI.low CI.high
## 1 Moca -0.126002473 -0.21899635 -0.03300860
## 2 TabCAT-Examiner -0.069401157 -0.17335700 0.03455468
## 3 TabCAT-Examiner (NA-Fluency) -0.035418538 -0.13677261 0.06593554
## 4 UDS3-EF -0.050016643 -0.14520213 0.04516884
## 5 Trail B Ratio -0.023449501 -0.10789078 0.06099177
## 6 Trail A Ratio -0.016781200 -0.10417457 0.07061217
## 7 DS fwd -0.017564121 -0.08850570 0.05337746
## 8 DS bwd -0.028850974 -0.10521721 0.04751527
## 9 MINT -0.106697886 -0.19756561 -0.01583016
## 10 Animals -0.033139674 -0.12261468 0.05633534
## 11 Veg -0.009617695 -0.09354254 0.07430715
## 12 Words (F) 0.009229773 -0.07338834 0.09184788
## 13 Words (L) -0.039761275 -0.11826771 0.03874516
## 14 Benson Copy -0.019618433 -0.08318796 0.04395109
## 15 Benson Recall -0.032420582 -0.11513753 0.05029637
## 16 Craft Immed. -0.042025633 -0.12313145 0.03908019
## 17 Craft Delay -0.033477293 -0.11675867 0.04980409
## iri_pt Estimate CI.low CI.high
## 1 Moca -0.07546178 -0.17098432 0.02006076
## 2 TabCAT-Examiner 0.01559803 -0.09097327 0.12216932
## 3 TabCAT-Examiner (NA-Fluency) 0.02005283 -0.09051369 0.13061934
## 4 UDS3-EF -0.02368919 -0.12137738 0.07399901
## 5 Trail B Ratio -0.01075306 -0.09728918 0.07578307
## 6 Trail A Ratio -0.01361056 -0.10547014 0.07824902
## 7 DS fwd -0.01789096 -0.09055398 0.05477206
## 8 DS bwd -0.01996029 -0.09763563 0.05771504
## 9 MINT -0.03695381 -0.12246368 0.04855605
## 10 Animals -0.02597231 -0.11737028 0.06542567
## 11 Veg -0.01149787 -0.09850512 0.07550937
## 12 Words (F) 0.01165669 -0.07285322 0.09616660
## 13 Words (L) -0.01062327 -0.09102352 0.06977698
## 14 Benson Copy -0.02411095 -0.08929518 0.04107328
## 15 Benson Recall -0.03182390 -0.11633311 0.05268531
## 16 Craft Immed. 0.02633695 -0.05674121 0.10941511
## 17 Craft Delay 0.05099350 -0.03448264 0.13646964
## rsms_sen Estimate CI.low CI.high
## 1 Moca -0.043394469 -0.12613309 0.03934416
## 2 TabCAT-Examiner 0.014367980 -0.07780553 0.10654149
## 3 TabCAT-Examiner (NA-Fluency) -0.041562599 -0.13070945 0.04758425
## 4 UDS3-EF 0.022871458 -0.06129197 0.10703489
## 5 Trail B Ratio -0.009771807 -0.08418175 0.06463814
## 6 Trail A Ratio -0.011610517 -0.08912533 0.06590430
## 7 DS fwd 0.006833025 -0.05588780 0.06955385
## 8 DS bwd -0.032693734 -0.09962329 0.03423582
## 9 MINT 0.038847142 -0.04202150 0.11971578
## 10 Animals 0.056772582 -0.02210289 0.13564806
## 11 Veg 0.018807652 -0.05504973 0.09266503
## 12 Words (F) 0.005975187 -0.06674782 0.07869819
## 13 Words (L) 0.007111995 -0.06178553 0.07600952
## 14 Benson Copy -0.071790196 -0.12792268 -0.01565771
## 15 Benson Recall 0.001094848 -0.07205219 0.07424189
## 16 Craft Immed. -0.016154223 -0.08796747 0.05565902
## 17 Craft Delay 0.017088067 -0.05697658 0.09115272
## rsms_selfpre Estimate CI.low CI.high
## 1 Moca 0.005358322 -0.083391893 0.09410854
## 2 TabCAT-Examiner 0.115192911 0.018001321 0.21238450
## 3 TabCAT-Examiner (NA-Fluency) 0.095508643 0.001567597 0.18944969
## 4 UDS3-EF 0.099745766 0.010464567 0.18902697
## 5 Trail B Ratio 0.046587421 -0.032412379 0.12558722
## 6 Trail A Ratio 0.069643578 -0.012304108 0.15159126
## 7 DS fwd 0.057090234 -0.009470563 0.12365103
## 8 DS bwd 0.031020976 -0.040435588 0.10247754
## 9 MINT -0.003622584 -0.088547266 0.08130210
## 10 Animals 0.100219685 0.016201018 0.18423835
## 11 Veg 0.067515108 -0.010439086 0.14546930
## 12 Words (F) 0.037784064 -0.039496247 0.11506438
## 13 Words (L) 0.042747854 -0.030651116 0.11614682
## 14 Benson Copy -0.024805146 -0.084773122 0.03516283
## 15 Benson Recall 0.014794980 -0.062729620 0.09231958
## 16 Craft Immed. 0.062920169 -0.013080285 0.13892062
## 17 Craft Delay 0.077093914 -0.001211445 0.15539927
## rsms_total Estimate CI.low CI.high
## 1 Moca -0.021815753 -0.104934361 0.061302855
## 2 TabCAT-Examiner 0.063188277 -0.028557614 0.154934168
## 3 TabCAT-Examiner (NA-Fluency) 0.022233120 -0.065817393 0.110283633
## 4 UDS3-EF 0.062525727 -0.021586446 0.146637900
## 5 Trail B Ratio 0.018146108 -0.056117782 0.092409998
## 6 Trail A Ratio 0.027211104 -0.050111681 0.104533889
## 7 DS fwd 0.029563430 -0.033181535 0.092308394
## 8 DS bwd -0.006151699 -0.073419917 0.061116519
## 9 MINT 0.021093479 -0.059098108 0.101285066
## 10 Animals 0.081071589 0.002296647 0.159846531
## 11 Veg 0.046802478 -0.026581544 0.120186500
## 12 Words (F) 0.023506634 -0.049206644 0.096219913
## 13 Words (L) 0.026756557 -0.042170519 0.095683633
## 14 Benson Copy -0.051121977 -0.107307359 0.005063405
## 15 Benson Recall 0.009036246 -0.063925609 0.081998101
## 16 Craft Immed. 0.024619696 -0.047034148 0.096273539
## 17 Craft Delay 0.048199976 -0.025765537 0.122165489TabCAT-EXAMINER early detection
Presents the ability of each task to discriminate between mutation carriers and non-carriers, in a sample with FTLD CDR global = 0. Negative coefficients suggest lower performance in carriers. This is restricted to the TabCAT-EXAMINER sample
## [1] "current cleaning matrix:"
## Variable_names
## education "educ,education,years_education,edu"
## flu_animal "animals,animal_fluency_total_correct,animalfluency_totalcorrect"
## flu_veg "veg"
## flu_fwords "udsverfc,fwords,UDSVERFC"
## flu_lwords "udsverlc,lwords,UDSVERLC"
## trails_a "traila"
## trails_b "trailb"
## dspan_fwd_length "digfwd_length,digforsl,digitfw_ucl"
## dspan_bck_length "digbwd_length,digbacls,digitbw_ucl"
## benson_delay "udsbentd"
## benson_copy "udsbentc,benson_temp"
## craft_v_delay "craftdvr"
## craft_v_immed "craftvrs"
## moca_total "mocatots,mocatotwitheduc"
## mmse_total "mmsetot,mmse_temp"
## mint_total "minttots"
## tabcat_match "match_totalcorrect,match_total_correct"
## tabcat_rundots "runningdots_totalcorrect,running_dots_trial_score"
## tabcat_dotcount "dotcounting_totalscore,dot_counting_total_score"
## tabcat_flanker "flanker_totalscore"
## tabcat_setshift "setshifting_totalscore,set_shifting_total_score"
## tabcat_favorite "favorites_alltrials_totalcorrect,favorites_all_trials_total_correct"
## tabcat_lineo "lo_thresholdscore_3.10,lo_threshold_score_3_10"
## cdr_sob "cdrsum,cdrbox"
## cdr_global "cdrglob,cdr global"
## ftldcdr_sob "ftldcdr_sb,ftld-cdr box,ftldcdr_sob,ftldcdrsob,ftldcdr_box,ftldcdr_sb,ftldcdrbox"
## ftldcdr_global "ftldcdr_glob,ftld-cdr global,ftldcdr_global,ftldcdrglobal,ftldcdrglob"
## cvltsf_tot_immed "trcotot,total_cvlt_temp"
## cvltsf_delay "corr10,cvsltsf_10_temp,cvlt_10min_correct"
## bnt15_corr "bntcorr_bedside"
## bnt30_corr "boston_uds,bnt_30"
## stroop_cn_bedside "strpcncor_bedside"
## stroop_inhib_bedside "strpcor_bedside"
## log_mem_immed "logimem"
## Log_mem_delay "MEMTIME,memtime"
## dig_fwd_sum "digforct"
## dig_back_sum "digbacct"
## df_corr "dfcor_temp"
## npi_total "npi_qtotal"
## faq_total "faqtotal"
## snq_total "ftdsntot"
## sboc_desc_total "ftdsbtot"
## sboc_behav_total "ftdsbcto"
## iri_emp "ftdiriec"
## iri_pt "ftdiript"
## rsms_sen "ftdsmscr"
## rsms_selfpre "ftdspscr"
## rsms_total "ftdrsmst"
## updrs_totalcln "updrs_score"
## psprs_totalcln "psprs_total"
## alsfrs_total "alsfrs_sum"
## Min Max Set to floor Set to ceiling Exclude
## education "0" "30" "NONE/NA" "NONE/NA" NA
## flu_animal "0" "60" "NONE/NA" "NONE/NA" NA
## flu_veg "0" "60" "NONE/NA" "NONE/NA" NA
## flu_fwords "0" "60" "NONE/NA" "NONE/NA" NA
## flu_lwords "0" "60" "NONE/NA" "NONE/NA" NA
## trails_a "0" "150" "NONE/NA" "NONE/NA" NA
## trails_b "0" "300" "NONE/NA" "NONE/NA" NA
## dspan_fwd_length "0" "10" "NONE/NA" "NONE/NA" NA
## dspan_bck_length "0" "10" "NONE/NA" "NONE/NA" NA
## benson_delay "0" "17" "NONE/NA" "NONE/NA" NA
## benson_copy "0" "17" "NONE/NA" "NONE/NA" NA
## craft_v_delay "0" "40" "NONE/NA" "NONE/NA" NA
## craft_v_immed "0" "40" "NONE/NA" "NONE/NA" NA
## moca_total "0" "30" "NONE/NA" "NONE/NA" NA
## mmse_total "0" "30" "NONE/NA" "NONE/NA" NA
## mint_total "0" "30" "NONE/NA" "NONE/NA" NA
## tabcat_match "0" "90" "NONE/NA" "NONE/NA" NA
## tabcat_rundots "0" "42" "NONE/NA" "NONE/NA" NA
## tabcat_dotcount "0" "27" "NONE/NA" "NONE/NA" NA
## tabcat_flanker "0" "11" "NONE/NA" "NONE/NA" NA
## tabcat_setshift "0" "11" "NONE/NA" "NONE/NA" NA
## tabcat_favorite "0" "24" "NONE/NA" "NONE/NA" NA
## tabcat_lineo "1" "50" "NONE/NA" "NONE/NA" NA
## cdr_sob "0" "18" "NONE/NA" "NONE/NA" NA
## cdr_global "0" "3" "NONE/NA" "NONE/NA" NA
## ftldcdr_sob "0" "24" "NONE/NA" "NONE/NA" NA
## ftldcdr_global "0" "3" "NONE/NA" "NONE/NA" NA
## cvltsf_tot_immed "0" "36" "NONE/NA" "NONE/NA" NA
## cvltsf_delay "0" "9" "NONE/NA" "NONE/NA" NA
## bnt15_corr "0" "15" "NONE/NA" "NONE/NA" NA
## bnt30_corr "0" "30" "NONE/NA" "NONE/NA" NA
## stroop_cn_bedside "0" "150" "NONE/NA" "NONE/NA" NA
## stroop_inhib_bedside "0" "100" "NONE/NA" "NONE/NA" NA
## log_mem_immed "0" "50" "NONE/NA" "NONE/NA" NA
## Log_mem_delay "0" "50" "NONE/NA" "NONE/NA" NA
## dig_fwd_sum "0" "16" "NONE/NA" "NONE/NA" NA
## dig_back_sum "0" "16" "NONE/NA" "NONE/NA" NA
## df_corr "0" "50" "NONE/NA" "NONE/NA" NA
## npi_total "0" "55" "NONE/NA" "NONE/NA" NA
## faq_total "0" "30" "NONE/NA" "NONE/NA" NA
## snq_total "0" "22" "NONE/NA" "NONE/NA" NA
## sboc_desc_total "0" "42" "NONE/NA" "NONE/NA" NA
## sboc_behav_total "0" "105" "NONE/NA" "NONE/NA" NA
## iri_emp "7" "35" "NONE/NA" "NONE/NA" NA
## iri_pt "7" "35" "NONE/NA" "NONE/NA" NA
## rsms_sen "0" "30" "NONE/NA" "NONE/NA" NA
## rsms_selfpre "0" "35" "NONE/NA" "NONE/NA" NA
## rsms_total "0" "65" "NONE/NA" "NONE/NA" NA
## updrs_totalcln "0" "80" "NONE/NA" "NONE/NA" NA
## psprs_totalcln "0" "77" "NONE/NA" "NONE/NA" NA
## alsfrs_total "6" "48" "NONE/NA" "NONE/NA" NA
## [1] "-------------------------------------------------------"
## [1] "Cleaned the following variables:"
## [1] "educ" "animals"
## [3] "veg" "udsverfc"
## [5] "fwords" "udsverlc"
## [7] "lwords" "traila"
## [9] "trailb" "digfwd_length"
## [11] "digforsl" "digbwd_length"
## [13] "digbacls" "udsbentd"
## [15] "udsbentc" "craftdvr"
## [17] "craftvrs" "mocatots"
## [19] "minttots" "match_totalcorrect"
## [21] "runningdots_totalcorrect" "dotcounting_totalscore"
## [23] "flanker_totalscore" "setshifting_totalscore"
## [25] "favorites_alltrials_totalcorrect" "lo_thresholdscore_3.10"
## [27] "cdrsum" "cdrglob"
## [29] "ftldcdr_sb" "ftldcdr_sb"
## [31] "ftldcdr_glob" "cvlt_10min_correct"
## [33] "digforct" "digbacct"
## [35] "npi_qtotal" "faqtotal"
## [37] "ftdsntot" "ftdsbtot"
## [39] "ftdsbcto" "ftdiriec"
## [41] "ftdiript" "ftdsmscr"
## [43] "ftdspscr" "ftdrsmst"
## [45] "updrs_score" "psprs_total"
## [47] "alsfrs_sum"
## [1] "-------------------------------------------------------"
## [1] 262 2060
##
## C9 GRN MAPT NONE OTHER UNKNOWN
## 43 22 16 91 3 87
## c9vsnone Estimate CI.low CI.high
## 1 Moca -0.14611842 -0.5398216 0.2475848
## 2 TabCAT-Examiner -0.08660466 -0.4237922 0.2505829
## 3 TabCAT-Examiner (NA-Fluency) -0.15255663 -0.5202817 0.2151684
## 4 UDS3-EF -0.07425154 -0.3982351 0.2497320
## 5 Trail B Ratio 0.14084424 -0.2073890 0.4890775
## 6 Trail A Ratio -0.17221624 -0.5069308 0.1624984
## 7 DS fwd 0.11943809 -0.2533267 0.4922029
## 8 DS bwd -0.05086332 -0.4172939 0.3155673
## 9 MINT 0.05636687 -0.5040124 0.6167462
## 10 Animals -0.03560867 -0.3857620 0.3145446
## 11 Veg -0.09558538 -0.4584654 0.2672946
## 12 Words (F) -0.11646134 -0.5037515 0.2708288
## 13 Words (L) 0.17035093 -0.1778758 0.5185777
## 14 Benson Copy -0.26386752 -0.6715721 0.1438371
## 15 Benson Recall -0.14051987 -0.4885136 0.2074739
## 16 Craft Immed. -0.13689861 -0.4953290 0.2215318
## 17 Craft Delay -0.16036322 -0.5284152 0.2076887
## grnvsnone Estimate CI.low CI.high
## 1 Moca -0.04490106 -0.4878404 0.39803830
## 2 TabCAT-Examiner -0.35102329 -0.7777443 0.07569772
## 3 TabCAT-Examiner (NA-Fluency) -0.28425197 -0.7328008 0.16429685
## 4 UDS3-EF -0.35221064 -0.8070043 0.10258300
## 5 Trail B Ratio -0.14255200 -0.6139253 0.32882133
## 6 Trail A Ratio -0.44867521 -0.8746407 -0.02270970
## 7 DS fwd -0.14761008 -0.6452858 0.35006561
## 8 DS bwd -0.38849983 -0.8397005 0.06270089
## 9 MINT -0.17201636 -0.9853052 0.64127249
## 10 Animals -0.07740263 -0.5160243 0.36121904
## 11 Veg -0.04526041 -0.5262061 0.43568525
## 12 Words (F) -0.03289493 -0.5680739 0.50228403
## 13 Words (L) -0.38890826 -0.8450600 0.06724345
## 14 Benson Copy -0.16827634 -0.6568867 0.32033398
## 15 Benson Recall -0.12494958 -0.5459733 0.29607410
## 16 Craft Immed. -0.09881552 -0.5436270 0.34599597
## 17 Craft Delay -0.28188619 -0.7229413 0.15916897
## maptvsnone Estimate CI.low CI.high
## 1 Moca -0.04490106 -0.4878404 0.39803830
## 2 TabCAT-Examiner -0.35102329 -0.7777443 0.07569772
## 3 TabCAT-Examiner (NA-Fluency) -0.28425197 -0.7328008 0.16429685
## 4 UDS3-EF -0.35221064 -0.8070043 0.10258300
## 5 Trail B Ratio -0.14255200 -0.6139253 0.32882133
## 6 Trail A Ratio -0.44867521 -0.8746407 -0.02270970
## 7 DS fwd -0.14761008 -0.6452858 0.35006561
## 8 DS bwd -0.38849983 -0.8397005 0.06270089
## 9 MINT -0.17201636 -0.9853052 0.64127249
## 10 Animals -0.07740263 -0.5160243 0.36121904
## 11 Veg -0.04526041 -0.5262061 0.43568525
## 12 Words (F) -0.03289493 -0.5680739 0.50228403
## 13 Words (L) -0.38890826 -0.8450600 0.06724345
## 14 Benson Copy -0.16827634 -0.6568867 0.32033398
## 15 Benson Recall -0.12494958 -0.5459733 0.29607410
## 16 Craft Immed. -0.09881552 -0.5436270 0.34599597
## 17 Craft Delay -0.28188619 -0.7229413 0.15916897
##
## 0 1
## 77 171
##
## Descriptive statistics by group
## group: 0
## vars n mean sd median trimmed mad min max range skew kurtosis se
## X1 1 77 0.26 0.63 0.26 0.28 0.54 -1.64 1.47 3.11 -0.37 0.22 0.07
## ------------------------------------------------------------
## group: 1
## vars n mean sd median trimmed mad min max range skew kurtosis se
## X1 1 171 0.27 0.75 0.26 0.27 0.78 -1.86 2.11 3.97 -0.09 -0.05 0.06
## mut_vs_famcont Estimate CI.low CI.high
## 1 Moca -0.1098183547 -0.23507187 0.01543516
## 2 TabCAT-Examiner -0.0594832755 -0.19690688 0.07794033
## 3 TabCAT-Examiner (NA-Fluency) -0.0792024143 -0.22540266 0.06699783
## 4 UDS3-EF -0.0418016985 -0.17162044 0.08801705
## 5 Trail B Ratio -0.0373659073 -0.17085311 0.09612130
## 6 Trail A Ratio -0.0626471917 -0.19510119 0.06980681
## 7 DS fwd 0.0836742013 -0.04140884 0.20875724
## 8 DS bwd -0.0131151703 -0.13802147 0.11179113
## 9 MINT 0.0063204299 -0.17703173 0.18967259
## 10 Animals 0.0337423115 -0.09522495 0.16270958
## 11 Veg 0.0008077428 -0.12770842 0.12932391
## 12 Words (F) -0.0545982356 -0.18057043 0.07137396
## 13 Words (L) -0.0208011610 -0.14545195 0.10384963
## 14 Benson Copy -0.0426476780 -0.17341177 0.08811641
## 15 Benson Recall -0.0914870546 -0.22045043 0.03747632
## 16 Craft Immed. -0.1813695231 -0.30399704 -0.05874200
## 17 Craft Delay -0.2085354507 -0.33331452 -0.08375638TabCAT-EXAMINER Power Analysis: Mutation and CDR
First, the forest plots present the average change per year in Z score units. The second plot presents the number of participants needed to detect a 25% (square) and 40 % (target) drug effect using each measure. Each tab presents a different subsample. All participants have CDR+NACC-FTLD Global Scores > 0. Only tasks with estimated sample sizes <1000 are displayed.
Mutation Positive
##
## C9 GRN MAPT UNKNOWN
## 16 1 11 42MAPT Carriers
The sample was limited to those with a CDR+NACC-FTLD Global Score >0 and with a MAPT mutation.
## Warning: Using one column matrices in `filter()` was deprecated in dplyr 1.1.0.
## ℹ Please use one dimensional logical vectors instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
##
## MAPT
## 9C9 Carriers
The sample was limited to those with a CDR+NACC-FTLD Global Score >0 and with a C9 mutation.
##
## C9
## 15GRN Carriers
The sample was limited to those with a CDR+NACC-FTLD Global Score >0 and with a GRN mutation. Sample size was <5; results removed.
TabCAT-EXAMINER Power Analysis by Syndrome
Similar to the power analyses above, I completed power analyses within a specific syndrome.
Cognitively Unimpaired
Presents a power analysis within the cognitively unimpaired cohort.
bvFTD
Presents a power analysis within the bvFTD cohort.
CBS
Presents a power analysis within the CBS cohort.
MCI (removed)
## [1] "Analyses are not displayed due to the low effect size within this group. All measures require >500 participants."nvPPA
Presents a power analysis within the nvPPA cohort.
PSP
Presents a power analysis within the PSP cohort.
svPPA
Presents a power analysis within the svPPA cohort.
AD+lvPPA
Presents a power analysis within a cohort that included those diagnosed with AD and/or lvPPA.
Sample size <5, removed.
TabCAT-EXAMINER CU vs Syndrome
The goal here was to see how measures preformed when considering syndrome since FTLD symptoms are heterogeneous. Across all comparisons, the CU group performs better on the global factor score as compared to the impaired group; this distinction is less significant when comparing via component measures (e.g., flanker, animals).
TabCAT-EXAMINER bvFTD
TabCAT-EXAMINER CBS
## TabCAT-EXAMINER MCI
TabCAT-EXAMINER nvPPA
TabCAT-EXAMINER PSP
TabCAT-EXAMINER svPPA
TabCAT-EXAMINER AD+lvPPA
TabCAT-EXAMINER within Familial FTLD
We present associations between TabCAT measures and the CDR+NACC-FTLD Sum of Boxes. Results are in forest plots.
We next created change scores for sum of boxes (time 2 minus time 1). Change scores were binarized into stable (no change or positive change) vs Worsen (increase in box score). These change scores were entered into a regression as an independent variable, controlling for age, education, and sex. The dependent variable was a single cognitive task. Results are presented in a forest plot. These regressions were completed within the available TabCAT sample. All participants had CDR+NACC-FTLD global scores of 0 or 0.5 at time 1.
[not shown]: Those who worsened over time were matched using propensity score matching to stable participants, based on age, education, and sex. A second series of regressions was then completed with this matched sample. Results were similar.
Association with Sum of Boxes
## ftldcdr_sb Estimate CI.low CI.high
## 1 TabCAT-EXAMINER -0.6470672 -0.7417852 -0.55234935
## 2 TabCAT-EXAMINER (NA Fluency) -0.1690247 -0.2390421 -0.09900738
## 3 uds3_ef -0.6131202 -0.6996004 -0.52664004
## 4 rundots -0.1874596 -0.2679461 -0.10697312
## 5 dotcount -0.3390113 -0.4281159 -0.24990678
## 6 flanker -0.2999184 -0.3857737 -0.21406314
## 7 setshift -0.3770034 -0.4770357 -0.27697107
## 8 match -0.5529784 -0.6568243 -0.44913245
## 9 animals -0.4773046 -0.5691533 -0.38545592
## 10 veg -0.4136073 -0.5063845 -0.32083002
## 11 fwords -0.4685568 -0.5580375 -0.37907606
## 12 lwords -0.3468815 -0.4398440 -0.25391905
Association with change in Sum of Boxes
NOTE: Negative scores indicate that the “Worsen” group has lower cognitive scores than the “Stable” group.
TabCAT-EXAMINER within Sporadic FTLD
Same analyses as within the familial FTLD sample.
We present associations between TabCAT measures and th CDR+NACC-FTLD Sum of Boxes. Results are in forest plots.
We next created change scores for sum of boxes (time 2 minus time 1). Change scores were binarized into stable (no change or positive change) vs Worsen (increase in box score). These change scores were entered into a regression as an independent varible, controling for age, education, and sex. The dependent variable was a single cognitive task. Results are presented in a forest plot. These regressions were completed within the avaliable TabCAT sample.
[not shown]: Those who worsened over time were matched using propensity score matching to stable participants, based on age, education, and sex. A second series of regressions was then completed with this matched sample. Results were similar.
## Association with Sum of Boxes
## ftldcdr_sb Estimate CI.low CI.high
## 1 TabCAT-EXAMINER -0.6342462 -0.7954442 -0.47304818
## 2 TabCAT-EXAMINER (NA Fluency) -0.3551528 -0.6071818 -0.10312378
## 3 uds3_ef -0.6131126 -0.7753721 -0.45085320
## 4 rundots -0.2530209 -0.4503512 -0.05569072
## 5 dotcount -0.3362126 -0.5226180 -0.14980713
## 6 flanker -0.4581601 -0.6446805 -0.27163970
## 7 setshift -0.2285233 -0.4278261 -0.02922061
## 8 match -0.5628976 -0.7407737 -0.38502143
## 9 animals -0.6096212 -0.7629731 -0.45626927
## 10 veg -0.5412713 -0.7112506 -0.37129212
## 11 fwords -0.5255572 -0.6996505 -0.35146391
## 12 lwords -0.5264841 -0.7042104 -0.34875789
Association with change in Sum of Boxes
NOTE: Negative scores indicate that the “Worsen” group has lower cognitive scores than the “Stable” group.
