Multicenter Test-Retest and Acquisition Protocol Reproducibility of Liver Iron Quantification

Author

Lu Mao

Statistical analysis

For test-retest repeatability of R2*, the Bland-Altman analysis was used to calculate the bias, limits of agreement (LoA), and coefficient of repeatability (half-width of LoA) by field strength, protocol, liver segment, lobe, and overall. Between-protocol reproducibility was assessed by similar Bland-Altman analysis by field strength, liver segment, lobe, and overall. Per guidelines of Raunig et al. (2014), the intra-class correlation coefficient (ICC) was used for repeatability analysis and the concordance correlation coefficient (CCC) for reproducibility analysis. P-values \(<\) 0.05 were considered statistically significant. All analyses were performed in R version 4.3.3 (R Foundation for Statistical Computing, Vienna, Austria).

Patient characteristics

Patient characteristics are summarized by site in Table 1.

Table 1: Patient characteristics by site.
Characteristic UW, N = 591 UTSW, N = 481 JHU, N = 521 Stanford, N = 461 Overall, N = 2051
Age (years) 51 (28, 59) 46 (34, 56) 30 (20, 53) 17 (12, 22) 36 (19, 54)
    Unknown 0 0 0 1 1
Sex




    f 20 (34%) 23 (48%) 29 (56%) 18 (40%) 90 (44%)
    m 39 (66%) 25 (52%) 23 (44%) 27 (60%) 114 (56%)
    Unknown 0 0 0 1 1
Weight (kg) 74 (66, 96) 75 (61, 102) 65 (55, 79) 53 (35, 67) 68 (56, 87)
    Unknown 0 1 0 6 7
Height (cm) 173 (163, 179) 172 (161, 182) 165 (159, 173) 157 (141, 167) 168 (158, 178)
    Unknown 0 1 0 6 7
Ferriscan LIC (mg/g) 4 (2, 8) 2 (1, 5) 6 (2, 15) 3 (1, 8) 3 (1, 8)
    Unknown 2 0 2 3 7
Ferriscan R2 (/s) 74 (51, 111) 43 (33, 83) 98 (50, 163) 65 (41, 117) 66 (40, 116)
    Unknown 2 0 2 3 7
Serum Ferritin (ng/mL) 659 (363, 1,702) 850 (466, 1,748) 1,231 (390, 3,095) 822 (577, 1,399) 889 (440, 1,918)
    Unknown 0 0 1 3 4
Disease Categories




    1 22 (37%) 20 (42%) 17 (33%) 7 (16%) 66 (33%)
    2 13 (22%) 20 (42%) 32 (63%) 28 (64%) 93 (46%)
    3 0 (0%) 1 (2.1%) 0 (0%) 2 (4.5%) 3 (1.5%)
    4 15 (25%) 1 (2.1%) 1 (2.0%) 6 (14%) 23 (11%)
    5 7 (12%) 0 (0%) 0 (0%) 0 (0%) 7 (3.5%)
    6 2 (3.4%) 6 (13%) 1 (2.0%) 1 (2.3%) 10 (5.0%)
    Unknown 0 0 1 2 3
1 Median (IQR); n (%)

Repeatability analysis

The number of pairs for test-retest repeatability analysis by protocol, field strength, and lobe is listed below.

Number of test-retest pairs in analysis
Protocol Field Lobe n
P01 1.5T Left lobe 480
P01 1.5T Right lobe 384
P01 3.0T Left lobe 470
P01 3.0T Right lobe 376
P02 1.5T Left lobe 480
P02 1.5T Right lobe 384
P02 3.0T Left lobe 460
P02 3.0T Right lobe 368
P04 1.5T Left lobe 475
P04 1.5T Right lobe 380
P04 3.0T Left lobe 430
P04 3.0T Right lobe 344
P08 1.5T Left lobe 455
P08 1.5T Right lobe 364
P08 3.0T Left lobe 425
P08 3.0T Right lobe 340

Overall

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol and field strength across all segments/lobes in Table 2 below.

Table 2: Test-retest repeatability analysis by protocol and field strength across all segments/lobes.
Protocol Field Bias Bias (%) (LoA %) CR ICC (95% CI) p-value
P01 1.5T 0.9 0.5% (-21.1%, 22.2%) 54.9 0.994 (0.993, 0.995) < 0.001
P01 3.0T -6.4 -0.2% (-18.5%, 18.1%) 129.7 0.991 (0.99, 0.992) < 0.001
P02 1.5T 1.3 0.2% (-19.9%, 20.2%) 53.2 0.994 (0.993, 0.994) < 0.001
P02 3.0T 2.8 0.4% (-19.9%, 20.7%) 135.5 0.989 (0.987, 0.99) < 0.001
P04 1.5T 0.2 0.5% (-21.6%, 22.7%) 70.0 0.988 (0.986, 0.989) < 0.001
P04 3.0T 1.4 0.3% (-32%, 32.6%) 155.5 0.975 (0.971, 0.978) < 0.001
P08 1.5T 0.8 0.2% (-25.2%, 25.7%) 66.1 0.987 (0.985, 0.989) < 0.001
P08 3.0T 2.3 0.9% (-30.7%, 32.5%) 134.9 0.965 (0.96, 0.97) < 0.001

Bland-Altman plots of test-retest repeatability by protocol for 1.5T and 3.0T are shown in Figure 1 and Figure 2, respectively.

Figure 1: Bland-Altman plot of test-retest repeatability of R2* in 1.5T by protocol.
Figure 2: Bland-Altman plot of test-retest repeatability of R2* in 3.0T by protocol.

By lobe

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol, field strength, and lobe in Table 3 below.

Table 3: Test-retest repeatability analysis by protocol, field strength, and lobe.
Protocol Field Lobe Bias Bias (%) (LoA %) CR ICC (95% CI) p-value
P01 1.5T Left 2.2 0.6% (-23.6%, 24.7%) 58.1 0.993 (0.992, 0.994) < 0.001
P01 1.5T Right -0.7 0.5% (-17.6%, 18.5%) 50.5 0.995 (0.994, 0.996) < 0.001
P01 3.0T Left -8.6 -0.3% (-21%, 20.4%) 147.0 0.988 (0.985, 0.99) < 0.001
P01 3.0T Right -3.7 -0.1% (-15%, 14.8%) 104.1 0.995 (0.994, 0.996) < 0.001
P02 1.5T Left 1.0 0.2% (-21.8%, 22.1%) 57.8 0.992 (0.99, 0.993) < 0.001
P02 1.5T Right 1.7 0.1% (-17.4%, 17.6%) 46.8 0.996 (0.995, 0.996) < 0.001
P02 3.0T Left 7.6 0.8% (-22.8%, 24.3%) 159.4 0.982 (0.978, 0.985) < 0.001
P02 3.0T Right -3.3 -0.1% (-15.4%, 15.2%) 96.7 0.995 (0.994, 0.996) < 0.001
P04 1.5T Left 0.3 0.5% (-25.1%, 26%) 71.5 0.986 (0.983, 0.988) < 0.001
P04 1.5T Right 0.1 0.6% (-16.5%, 17.6%) 68.1 0.99 (0.988, 0.992) < 0.001
P04 3.0T Left 0.7 0.4% (-32.9%, 33.8%) 152.5 0.968 (0.961, 0.973) < 0.001
P04 3.0T Right 2.2 0.1% (-30.9%, 31.1%) 159.5 0.98 (0.975, 0.983) < 0.001
P08 1.5T Left 1.4 0.5% (-26.4%, 27.4%) 66.6 0.985 (0.982, 0.987) < 0.001
P08 1.5T Right 0.1 -0.1% (-23.6%, 23.4%) 65.5 0.989 (0.986, 0.991) < 0.001
P08 3.0T Left 1.2 1.1% (-34.9%, 37.1%) 124.7 0.956 (0.948, 0.964) < 0.001
P08 3.0T Right 3.7 0.7% (-24.5%, 25.8%) 146.8 0.97 (0.963, 0.976) < 0.001

Bland-Altman plots of test-retest repeatability by protocol and lobe for 1.5T and 3.0T are shown in Figure 3 and Figure 4, respectively.

Figure 3: Bland-Altman plot of test-retest repeatability of R2* in 1.5T by protocol and lobe.
Figure 4: Bland-Altman plot of test-retest repeatability of R2* in 3.0T by protocol and lobe.

By segment

The test-retest bias, coefficient of repeatability (CR), intra-class correlation (ICC) coefficient and 95% confidence interval (CI) are summarized by protocol, field strength, and segment in Table 4 below.

Table 4: Test-retest repeatability analysis by protocol, field strength, and segment.
Protocol Field Segment Bias Bias (%) (LoA %) CR ICC (95% CI) p-value
P01 1.5T I -3.2 -1.3% (-30.7%, 28.1%) 55.9 0.993 (0.99, 0.995) < 0.001
II 3.1 -1.1% (-22.3%, 20.2%) 81.1 0.986 (0.979, 0.99) < 0.001
III 3.9 0.9% (-22.4%, 24.3%) 62.3 0.992 (0.989, 0.995) < 0.001
IVA 6.7 4.1% (-21.1%, 29.2%) 49.6 0.995 (0.992, 0.997) < 0.001
IVB 0.4 0.1% (-19.4%, 19.7%) 27.7 0.998 (0.998, 0.999) < 0.001
V 1.2 0.1% (-11%, 11.3%) 27.1 0.999 (0.998, 0.999) < 0.001
VI -1.4 0.9% (-23.3%, 25.1%) 40.7 0.997 (0.996, 0.998) < 0.001
VII -2.8 0.8% (-16.4%, 17.9%) 80.1 0.989 (0.983, 0.992) < 0.001
VIII 0.0 0.1% (-17.5%, 17.7%) 38.0 0.998 (0.996, 0.998) < 0.001
P01 3.0T I -1.5 0% (-20.5%, 20.5%) 113.7 0.992 (0.987, 0.994) < 0.001
II -14.4 -0.5% (-25.3%, 24.4%) 188.0 0.98 (0.97, 0.987) < 0.001
III -11.1 0.4% (-18.3%, 19%) 133.5 0.989 (0.984, 0.993) < 0.001
IVA -10.2 -0.9% (-20.6%, 18.8%) 139.6 0.991 (0.986, 0.994) < 0.001
IVB -5.8 -0.4% (-19.9%, 19.1%) 151.7 0.987 (0.981, 0.992) < 0.001
V -3.5 -0.2% (-15.8%, 15.4%) 91.2 0.996 (0.994, 0.997) < 0.001
VI 1.8 0.3% (-11.8%, 12.3%) 71.5 0.998 (0.997, 0.998) < 0.001
VII -4.9 0.9% (-13.7%, 15.4%) 88.6 0.996 (0.994, 0.997) < 0.001
VIII -8.1 -1.3% (-18.1%, 15.6%) 149.0 0.989 (0.984, 0.993) < 0.001
P02 1.5T I 5.5 0.9% (-26.1%, 28%) 55.0 0.991 (0.987, 0.994) < 0.001
II -1.7 -0.4% (-23.1%, 22.2%) 62.3 0.99 (0.985, 0.993) < 0.001
III 0.6 -0.9% (-24%, 22.2%) 55.2 0.993 (0.99, 0.995) < 0.001
IVA 1.7 1.5% (-19.4%, 22.5%) 62.0 0.992 (0.988, 0.995) < 0.001
IVB -1.4 -0.2% (-14.2%, 13.7%) 54.1 0.993 (0.99, 0.996) < 0.001
V 2.0 -0.5% (-12.4%, 11.5%) 40.1 0.997 (0.995, 0.998) < 0.001
VI -3.0 -1.1% (-19%, 16.9%) 43.6 0.996 (0.994, 0.998) < 0.001
VII 2.1 0.4% (-16.8%, 17.6%) 52.9 0.994 (0.991, 0.996) < 0.001
VIII 5.7 1.6% (-19.7%, 22.8%) 48.7 0.995 (0.992, 0.997) < 0.001
P02 3.0T I 3.2 0.1% (-27%, 27.2%) 112.7 0.99 (0.985, 0.993) < 0.001
II -10.6 0.4% (-26%, 26.8%) 211.9 0.961 (0.942, 0.974) < 0.001
III 25.0 0.5% (-25.7%, 26.7%) 199.6 0.972 (0.957, 0.981) < 0.001
IVA 5.9 0.8% (-17.8%, 19.4%) 101.3 0.994 (0.991, 0.996) < 0.001
IVB 14.6 2% (-16.2%, 20.1%) 133.2 0.987 (0.981, 0.992) < 0.001
V 3.2 1.2% (-14.3%, 16.7%) 83.5 0.996 (0.994, 0.997) < 0.001
VI -1.3 -0.5% (-14.8%, 13.7%) 100.6 0.995 (0.993, 0.997) < 0.001
VII -7.4 -1% (-17%, 15%) 94.2 0.995 (0.992, 0.997) < 0.001
VIII -7.5 -0.1% (-15.4%, 15.1%) 107.0 0.994 (0.991, 0.996) < 0.001
P04 1.5T I 0.8 1.8% (-23.9%, 27.5%) 55.4 0.99 (0.985, 0.993) < 0.001
II 0.8 -0.2% (-29.8%, 29.5%) 68.5 0.986 (0.979, 0.99) < 0.001
III 2.7 0.9% (-27.2%, 29%) 57.1 0.992 (0.987, 0.994) < 0.001
IVA -1.9 0.5% (-19.4%, 20.5%) 71.6 0.987 (0.98, 0.991) < 0.001
IVB -0.8 -0.8% (-24%, 22.4%) 98.0 0.978 (0.967, 0.985) < 0.001
V 6.1 1.1% (-11.6%, 13.7%) 63.1 0.991 (0.987, 0.994) < 0.001
VI -2.6 1.3% (-13.3%, 15.8%) 60.2 0.993 (0.989, 0.995) < 0.001
VII 0.1 0.4% (-21%, 21.8%) 74.0 0.988 (0.981, 0.992) < 0.001
VIII -3.3 -0.5% (-18.9%, 18%) 73.6 0.988 (0.983, 0.992) < 0.001
P04 3.0T I -4.8 -0.7% (-39.6%, 38.1%) 134.8 0.968 (0.952, 0.979) < 0.001
II -7.8 -0.9% (-40.5%, 38.7%) 174.0 0.924 (0.886, 0.95) < 0.001
III 5.1 0.6% (-33.5%, 34.8%) 183.4 0.961 (0.941, 0.975) < 0.001
IVA 12.6 1.8% (-26.8%, 30.4%) 166.7 0.971 (0.955, 0.981) < 0.001
IVB -1.8 1.4% (-21.8%, 24.6%) 80.0 0.992 (0.988, 0.995) < 0.001
V 5.1 -0.9% (-18.5%, 16.6%) 119.6 0.988 (0.982, 0.992) < 0.001
VI 7.0 0.4% (-22.3%, 23.1%) 199.8 0.972 (0.958, 0.982) < 0.001
VII 3.8 1% (-20.5%, 22.5%) 152.9 0.981 (0.97, 0.987) < 0.001
VIII -6.9 0% (-50.8%, 50.8%) 156.6 0.978 (0.967, 0.986) < 0.001
P08 1.5T I 5.0 -0.1% (-22.6%, 22.4%) 72.9 0.979 (0.968, 0.986) < 0.001
II 2.3 1.5% (-27.5%, 30.4%) 55.8 0.989 (0.984, 0.993) < 0.001
III -2.0 0.6% (-27.5%, 28.8%) 69.1 0.984 (0.976, 0.989) < 0.001
IVA 2.4 1.6% (-30.8%, 34.1%) 71.8 0.984 (0.975, 0.989) < 0.001
IVB -0.5 -1.3% (-22.3%, 19.7%) 62.3 0.988 (0.983, 0.992) < 0.001
V 0.6 -0.7% (-19.4%, 18.1%) 86.4 0.981 (0.972, 0.987) < 0.001
VI -2.8 -0.3% (-22.9%, 22.2%) 50.7 0.994 (0.99, 0.996) < 0.001
VII 3.7 1.9% (-29.2%, 33.1%) 44.3 0.994 (0.992, 0.996) < 0.001
VIII -1.3 -1.3% (-20.7%, 18.1%) 72.3 0.987 (0.981, 0.992) < 0.001
P08 3.0T I 1.0 0.7% (-30.1%, 31.5%) 89.5 0.972 (0.957, 0.981) < 0.001
II 0.7 2.9% (-36.6%, 42.3%) 107.9 0.956 (0.934, 0.971) < 0.001
III 12.3 2.6% (-33%, 38.3%) 169.4 0.923 (0.885, 0.949) < 0.001
IVA 0.7 -1% (-42%, 40%) 114.4 0.974 (0.96, 0.983) < 0.001
IVB -8.8 0.3% (-31.9%, 32.6%) 127.0 0.955 (0.932, 0.971) < 0.001
V 1.5 -0.4% (-20.9%, 20.1%) 124.8 0.978 (0.967, 0.986) < 0.001
VI 7.7 1.7% (-26.3%, 29.6%) 210.1 0.947 (0.92, 0.965) < 0.001
VII 5.3 1.3% (-23.6%, 26.2%) 111.0 0.981 (0.971, 0.988) < 0.001
VIII 0.1 0% (-26.9%, 26.9%) 121.6 0.98 (0.97, 0.987) < 0.001

Bland-Altman plots of test-retest repeatability by protocol and segment for 1.5T and 3.0T are shown in Figure 5 and Figure 6, respectively.

Figure 5: Bland-Altman plot of test-retest repeatability of R2* in 1.5T by protocol and segment.
Figure 6: Bland-Altman plot of test-retest repeatability of R2* in 3.0T by protocol and segment.

Reproducibility analysis

The number of observations for between-protocol reproducibility analysis by field strength and lobe is listed below.

Number of observations in between-protocol reproducibility analysis
Protocol Field Lobe n
P01 1.5T Left lobe 990
P01 1.5T Right lobe 792
P01 3.0T Left lobe 960
P01 3.0T Right lobe 768
P02 1.5T Left lobe 975
P02 1.5T Right lobe 780
P02 3.0T Left lobe 925
P02 3.0T Right lobe 740
P03 1.5T Left lobe 490
P03 1.5T Right lobe 392
P03 3.0T Left lobe 455
P03 3.0T Right lobe 364
P04 1.5T Left lobe 975
P04 1.5T Right lobe 780
P04 3.0T Left lobe 905
P04 3.0T Right lobe 724
P05 1.5T Left lobe 480
P05 1.5T Right lobe 384
P05 3.0T Left lobe 450
P05 3.0T Right lobe 360
P06 1.5T Left lobe 455
P06 1.5T Right lobe 364
P06 3.0T Left lobe 440
P06 3.0T Right lobe 352
P07 1.5T Left lobe 485
P07 1.5T Right lobe 388
P07 3.0T Left lobe 440
P07 3.0T Right lobe 352
P08 1.5T Left lobe 945
P08 1.5T Right lobe 756
P08 3.0T Left lobe 875
P08 3.0T Right lobe 700
P09 1.5T Left lobe 435
P09 1.5T Right lobe 348
P09 3.0T Left lobe 360
P09 3.0T Right lobe 288
P10 1.5T Left lobe 415
P10 1.5T Right lobe 332
P10 3.0T Left lobe 375
P10 3.0T Right lobe 300

Overall

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized across all segments/lobes for 1.5T and 3.0 T in Table 5 and Table 6, respectively.

CCC heatmap

Pairwise CCC is visualized in Figure 7 below.

Figure 7: Pairwise CCC for between-protocol reproducibility.

1.5T

Table 5: Between-protocol reproducibility analysis across all segments/lobes for 1.5T.
Protocol x Protocol y Bias Bias (%) (LoA %) CR CCC (95% CI)
P01 P02 12.8 5.5% (-17.8%, 28.8%) 74.9 0.99 (0.989, 0.99)
P03 35.3 7.2% (-32.1%, 46.5%) 282.8 0.86 (0.845, 0.874)
P04 20.6 5.3% (-24.8%, 35.5%) 178.5 0.938 (0.933, 0.943)
P05 51.5 13.1% (-25.1%, 51.3%) 302.1 0.825 (0.807, 0.841)
P06 34.5 10.5% (-22.6%, 43.6%) 176.2 0.915 (0.906, 0.923)
P07 59.6 14.5% (-29.3%, 58.3%) 353.0 0.752 (0.729, 0.773)
P08 39.1 10.7% (-24.2%, 45.7%) 240.2 0.876 (0.867, 0.885)
P09 60.6 12.6% (-42.1%, 67.3%) 411.2 0.684 (0.653, 0.714)
P10 68.5 14.6% (-45.5%, 74.8%) 448.4 0.654 (0.619, 0.687)
P02 P03 21.4 1.1% (-40.7%, 42.9%) 251.3 0.885 (0.871, 0.897)
P04 7.7 -0.4% (-30.4%, 29.6%) 152.2 0.954 (0.949, 0.957)
P05 38.5 7.1% (-33.8%, 48%) 262.5 0.859 (0.845, 0.873)
P06 21.9 3.9% (-32.4%, 40.2%) 145.6 0.94 (0.933, 0.946)
P07 47.4 8.8% (-37.5%, 55.1%) 316.7 0.786 (0.765, 0.805)
P08 26.7 5.2% (-30.3%, 40.6%) 210.8 0.9 (0.892, 0.907)
P09 47.1 6.5% (-51%, 63.9%) 375.4 0.719 (0.689, 0.747)
P10 52.6 8.2% (-53.7%, 70%) 410.3 0.686 (0.652, 0.717)
P03 P04 -7.1 -0.7% (-32.3%, 31%) 138.2 0.961 (0.956, 0.966)
P05 17.7 6% (-26.1%, 38.2%) 142.7 0.95 (0.944, 0.956)
P06 19.9 5% (-28.2%, 38.3%) 138.1 0.945 (0.938, 0.951)
P07 27.2 7.8% (-31.2%, 46.8%) 188.3 0.906 (0.894, 0.916)
P08 17.0 6.1% (-27.9%, 40.1%) 144.8 0.949 (0.943, 0.955)
P09 26.7 6.5% (-36.9%, 49.9%) 188.6 0.909 (0.897, 0.92)
P10 29.1 7.4% (-42%, 56.9%) 218.0 0.888 (0.873, 0.901)
P04 P05 24.7 6.9% (-21.4%, 35.1%) 134.6 0.955 (0.95, 0.96)
P06 22.2 5.3% (-27.2%, 37.8%) 142.8 0.941 (0.934, 0.948)
P07 34.2 8.6% (-27.7%, 45%) 195.5 0.901 (0.89, 0.911)
P08 20.0 5.9% (-23.3%, 35.1%) 132.9 0.954 (0.95, 0.958)
P09 34.1 6.7% (-42.1%, 55.6%) 240.4 0.861 (0.844, 0.877)
P10 37.2 8.1% (-44.9%, 61.1%) 271.4 0.836 (0.816, 0.855)
P05 P06 4.1 -0.5% (-30.6%, 29.6%) 112.0 0.962 (0.957, 0.967)
P07 10.0 2.1% (-34.1%, 38.2%) 158.4 0.93 (0.92, 0.938)
P08 -0.5 -0.1% (-33.7%, 33.4%) 127.2 0.959 (0.953, 0.964)
P09 8.9 0.3% (-45.7%, 46.4%) 188.4 0.905 (0.891, 0.917)
P10 11.9 1.4% (-46.9%, 49.7%) 208.9 0.892 (0.876, 0.906)
P06 P07 1.8 1.8% (-32.8%, 36.4%) 125.5 0.949 (0.942, 0.956)
P08 -6.0 0.4% (-31%, 31.7%) 115.7 0.961 (0.955, 0.965)
P09 -2.7 -0.8% (-38.3%, 36.7%) 117.0 0.959 (0.953, 0.965)
P10 -0.6 0.4% (-42.2%, 43%) 153.3 0.935 (0.925, 0.944)
P07 P08 -10.3 -2% (-39.5%, 35.4%) 153.1 0.935 (0.926, 0.943)
P09 -0.5 -1.6% (-44.6%, 41.5%) 152.7 0.933 (0.923, 0.942)
P10 1.0 -0.2% (-48%, 47.6%) 180.9 0.913 (0.9, 0.924)
P08 P09 7.7 0.1% (-44.9%, 45.1%) 172.7 0.92 (0.909, 0.93)
P10 12.7 1.6% (-47.5%, 50.6%) 206.7 0.895 (0.88, 0.909)
P09 P10 -1.1 0.8% (-40.9%, 42.6%) 133.6 0.949 (0.942, 0.956)

3.0T

Table 6: Between-protocol reproducibility analysis across all segments/lobes for 3.0T.
Protocol x Protocol y Bias Bias (%) (LoA %) CR CCC (95% CI)
P01 P02 31.4 5.9% (-18.3%, 30.2%) 241.4 0.968 (0.965, 0.97)
P03 114.3 11.4% (-57.9%, 80.6%) 721.6 0.65 (0.616, 0.681)
P04 94.9 9.9% (-52.1%, 71.9%) 643.8 0.707 (0.687, 0.727)
P05 164.7 19.6% (-58.8%, 98.1%) 842.0 0.495 (0.456, 0.531)
P06 173.0 20.5% (-59.3%, 100.3%) 859.8 0.467 (0.428, 0.504)
P07 156.1 20.4% (-54.4%, 95.2%) 752.7 0.552 (0.515, 0.586)
P08 140.1 17.1% (-49.8%, 84%) 754.4 0.551 (0.526, 0.575)
P09 50.5 3.8% (-63.5%, 71.1%) 501.4 0.746 (0.714, 0.775)
P10 177.8 20.3% (-72.3%, 113%) 934.3 0.442 (0.395, 0.488)
P02 P03 69.4 4.5% (-57.9%, 67%) 638.1 0.685 (0.651, 0.715)
P04 54.5 3.1% (-52.4%, 58.6%) 544.6 0.766 (0.748, 0.783)
P05 109.4 12% (-56.5%, 80.5%) 689.0 0.59 (0.554, 0.625)
P06 125.8 14.4% (-61.1%, 89.9%) 723.7 0.541 (0.502, 0.578)
P07 103.9 12.6% (-52.1%, 77.4%) 641.0 0.624 (0.588, 0.657)
P08 105.3 11.2% (-54.3%, 76.7%) 671.0 0.595 (0.57, 0.618)
P09 8.0 -2.8% (-61.9%, 56.2%) 361.1 0.845 (0.822, 0.865)
P10 120.7 13.4% (-74.9%, 101.6%) 796.6 0.518 (0.47, 0.563)
P03 P04 5.0 1.2% (-43.7%, 46.1%) 238.5 0.936 (0.927, 0.944)
P05 44.6 8.6% (-36.3%, 53.5%) 280.3 0.895 (0.881, 0.907)
P06 61.3 11.3% (-45.2%, 67.8%) 331.8 0.847 (0.828, 0.864)
P07 54.7 11% (-41.7%, 63.8%) 314.7 0.864 (0.847, 0.88)
P08 38.9 8% (-32.9%, 48.8%) 253.0 0.912 (0.9, 0.922)
P09 13.8 -0.5% (-62.7%, 61.7%) 362.2 0.84 (0.817, 0.861)
P10 46.0 9.8% (-61.8%, 81.4%) 385.0 0.832 (0.808, 0.853)
P04 P05 40.1 8% (-40.3%, 56.2%) 237.9 0.918 (0.908, 0.928)
P06 54.0 10% (-42.4%, 62.5%) 269.5 0.89 (0.876, 0.902)
P07 47.6 9.7% (-39.3%, 58.8%) 232.8 0.918 (0.908, 0.928)
P08 43.5 7.6% (-34.3%, 49.6%) 268.7 0.895 (0.886, 0.903)
P09 5.5 -2.2% (-62.7%, 58.4%) 302.0 0.883 (0.865, 0.899)
P10 34.3 8% (-61.2%, 77.1%) 298.0 0.892 (0.876, 0.906)
P05 P06 15.7 2.8% (-51%, 56.6%) 239.3 0.91 (0.897, 0.921)
P07 9.0 2.3% (-44.3%, 48.8%) 224.8 0.923 (0.912, 0.932)
P08 -2.1 0.1% (-41.9%, 42.1%) 199.5 0.939 (0.93, 0.947)
P09 -26.7 -8.2% (-70.1%, 53.7%) 316.8 0.853 (0.83, 0.873)
P10 -3.4 0.7% (-64.2%, 65.5%) 323.2 0.863 (0.842, 0.882)
P06 P07 -6.6 -0.6% (-54.8%, 53.6%) 247.1 0.904 (0.89, 0.916)
P08 -17.8 -2.7% (-54.2%, 48.8%) 216.5 0.924 (0.913, 0.934)
P09 -43.4 -10.9% (-74.1%, 52.4%) 306.1 0.85 (0.827, 0.87)
P10 -19.1 -1.5% (-71.6%, 68.7%) 303.4 0.874 (0.855, 0.891)
P07 P08 -15.7 -2.9% (-47.7%, 41.8%) 216.8 0.924 (0.913, 0.934)
P09 -38.3 -10.6% (-69.3%, 48.1%) 286.0 0.871 (0.851, 0.889)
P10 -17.2 -2.6% (-65.3%, 60.1%) 277.9 0.897 (0.881, 0.911)
P08 P09 -24.2 -8.5% (-66.7%, 49.8%) 296.1 0.871 (0.851, 0.888)
P10 6.1 2.3% (-68.5%, 73.1%) 293.7 0.878 (0.859, 0.895)
P09 P10 17.4 5.8% (-49.9%, 61.5%) 254.7 0.908 (0.893, 0.921)

Bland-Altman plots

Bland-Altman plots of between-protocol reproducibility for 1.5T and 3.0T are shown in Figure 8 and Figure 9, respectively.

Figure 8: Bland-Altman plot of between-protocol reproducibility of R2* in 1.5T.
Figure 9: Bland-Altman plot of between-protocol reproducibility of R2* in 3.0T.

By lobe

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized by lobe for 1.5T and 3.0 T in Table 7 and Table 8, respectively.

CCC heatmap

Pairwise CCC is visualized in Figure 10 below.

Figure 10: Pairwise CCC for between-protocol reproducibility by lobe.

1.5T

Table 7: Between-protocol reproducibility analysis of R2* by lobe in 1.5T.
Lobe Protocol x Protocol y Bias Bias (%) (LoA %) CR CCC (95% CI)
Left P01 P02 13.3 5.6% (-19.1%, 30.3%) 87.2 0.985 (0.983, 0.987)
P03 37.4 8.2% (-34.2%, 50.6%) 295.3 0.833 (0.808, 0.855)
P04 22.7 6% (-27.5%, 39.5%) 191.4 0.923 (0.914, 0.931)
P05 54.2 14.4% (-27.9%, 56.7%) 311.2 0.794 (0.767, 0.819)
P06 37.5 11.9% (-24.1%, 48%) 195.7 0.89 (0.874, 0.904)
P07 56.8 14.9% (-28.8%, 58.7%) 327.5 0.77 (0.74, 0.797)
P08 40.5 11.4% (-26.5%, 49.4%) 239.6 0.866 (0.853, 0.878)
P09 59.7 13% (-44.4%, 70.4%) 393.8 0.687 (0.643, 0.726)
P10 68.0 15.3% (-45.4%, 76%) 429.5 0.655 (0.607, 0.698)
P02 P03 23.5 2.1% (-41.9%, 46%) 254.7 0.867 (0.846, 0.886)
P04 9.6 0.3% (-33.6%, 34.2%) 162.4 0.941 (0.934, 0.948)
P05 41.0 8.4% (-35.3%, 52%) 262.8 0.841 (0.818, 0.861)
P06 25.2 5.3% (-32.5%, 43.1%) 156.4 0.925 (0.914, 0.935)
P07 44.4 9.2% (-36.9%, 55.3%) 283.1 0.813 (0.787, 0.836)
P08 27.7 6% (-32.4%, 44.3%) 205.7 0.894 (0.883, 0.905)
P09 44.4 6.3% (-53.7%, 66.2%) 348.3 0.735 (0.695, 0.77)
P10 52.1 8.5% (-54.3%, 71.3%) 386.2 0.694 (0.649, 0.735)
P03 P04 -8.2 -0.9% (-36.2%, 34.3%) 153.2 0.947 (0.937, 0.955)
P05 18.6 6.4% (-29.1%, 41.9%) 143.5 0.942 (0.932, 0.951)
P06 22.1 5.9% (-31.2%, 43%) 154.4 0.925 (0.912, 0.936)
P07 22.1 7.2% (-32.7%, 47.2%) 170.4 0.917 (0.903, 0.929)
P08 16.1 6% (-29.7%, 41.8%) 144.5 0.944 (0.934, 0.952)
P09 22.8 5.7% (-38.5%, 49.8%) 162.0 0.927 (0.913, 0.938)
P10 25.9 7% (-38.8%, 52.8%) 182.5 0.913 (0.897, 0.927)
P04 P05 26.4 7.4% (-23.4%, 38.3%) 142.7 0.944 (0.935, 0.951)
P06 25.3 6.3% (-28.8%, 41.5%) 161.1 0.919 (0.906, 0.931)
P07 30.1 8.2% (-28.4%, 44.8%) 170.6 0.919 (0.906, 0.93)
P08 20.5 6.1% (-26.8%, 39.1%) 146.0 0.939 (0.932, 0.945)
P09 31.6 6.1% (-46%, 58.3%) 230.9 0.862 (0.838, 0.882)
P10 35.8 7.8% (-46.1%, 61.6%) 258.9 0.839 (0.811, 0.863)
P05 P06 5.2 0.1% (-33.9%, 34.1%) 122.3 0.949 (0.939, 0.958)
P07 3.9 0.9% (-36%, 37.9%) 139.2 0.941 (0.93, 0.951)
P08 -2.5 -0.7% (-39.7%, 38.2%) 144.2 0.94 (0.929, 0.95)
P09 3.1 -1.3% (-49.8%, 47.1%) 172.9 0.911 (0.892, 0.926)
P10 7.1 0.3% (-49.3%, 49.8%) 198.6 0.892 (0.87, 0.91)
P06 P07 -1.9 0.8% (-37.6%, 39.2%) 134.7 0.936 (0.924, 0.947)
P08 -7.4 -0.3% (-34.9%, 34.2%) 124.3 0.949 (0.94, 0.958)
P09 -3.3 -1.9% (-41.9%, 38.1%) 125.5 0.948 (0.937, 0.957)
P10 -4.1 -0.9% (-41.7%, 39.9%) 146.2 0.936 (0.922, 0.947)
P07 P08 -6.0 -1.4% (-39.6%, 36.8%) 140.5 0.942 (0.931, 0.951)
P09 0.3 -1.9% (-50.8%, 47%) 170.1 0.913 (0.895, 0.928)
P10 2.9 0% (-49.9%, 49.8%) 178.2 0.911 (0.892, 0.926)
P08 P09 3.7 -1% (-50.1%, 48.1%) 173.3 0.913 (0.895, 0.927)
P10 10.5 1.1% (-50.3%, 52.5%) 197.2 0.897 (0.876, 0.914)
P09 P10 -0.5 1% (-43.8%, 45.8%) 130.9 0.948 (0.937, 0.957)
Right P01 P02 12.3 5.4% (-15.9%, 26.8%) 55.8 0.994 (0.994, 0.995)
P03 32.7 5.9% (-28.9%, 40.7%) 266.8 0.888 (0.87, 0.905)
P04 18.0 4.5% (-20.7%, 29.8%) 160.9 0.954 (0.949, 0.959)
P05 48.1 11.4% (-20.6%, 43.5%) 290.8 0.855 (0.834, 0.874)
P06 30.8 8.7% (-20.1%, 37.4%) 148.1 0.943 (0.934, 0.95)
P07 63.1 14% (-29.9%, 58%) 382.9 0.733 (0.696, 0.766)
P08 37.3 9.9% (-20.8%, 40.6%) 241.0 0.887 (0.874, 0.898)
P09 61.8 12.2% (-39%, 63.3%) 432.5 0.682 (0.634, 0.724)
P10 69.1 13.8% (-45.7%, 73.2%) 471.6 0.654 (0.6, 0.701)
P02 P03 18.6 -0.2% (-39%, 38.7%) 247.2 0.902 (0.884, 0.917)
P04 5.4 -1.3% (-25.6%, 23%) 138.4 0.966 (0.961, 0.97)
P05 35.4 5.5% (-31.6%, 42.5%) 262.4 0.878 (0.858, 0.895)
P06 17.7 2.1% (-31.9%, 36.2%) 130.6 0.956 (0.948, 0.962)
P07 51.1 8.3% (-38.3%, 54.9%) 354.4 0.758 (0.723, 0.789)
P08 25.5 4.2% (-27.2%, 35.5%) 217.1 0.906 (0.894, 0.916)
P09 50.5 6.8% (-47.4%, 60.9%) 407.1 0.703 (0.656, 0.744)
P10 53.3 7.8% (-52.9%, 68.5%) 439.1 0.678 (0.625, 0.724)
P03 P04 -5.6 -0.3% (-26.8%, 26.2%) 116.8 0.975 (0.97, 0.98)
P05 16.6 5.6% (-21.9%, 33%) 142.0 0.957 (0.949, 0.965)
P06 17.3 4% (-23.6%, 31.5%) 114.5 0.965 (0.959, 0.971)
P07 33.7 8.6% (-29.2%, 46.4%) 208.1 0.894 (0.875, 0.91)
P08 18.1 6.1% (-25.6%, 37.8%) 145.4 0.954 (0.945, 0.962)
P09 31.7 7.6% (-35%, 50.1%) 217.1 0.891 (0.869, 0.909)
P10 33.1 7.9% (-45.8%, 61.7%) 255.5 0.862 (0.834, 0.886)
P04 P05 22.5 6.1% (-18.5%, 30.8%) 123.7 0.967 (0.961, 0.972)
P06 18.3 4% (-24.7%, 32.6%) 115.8 0.965 (0.958, 0.97)
P07 39.2 9.1% (-26.9%, 45.2%) 222.6 0.882 (0.863, 0.9)
P08 19.5 5.6% (-18.1%, 29.3%) 114.6 0.969 (0.965, 0.972)
P09 37.3 7.5% (-37%, 52%) 251.9 0.861 (0.835, 0.883)
P10 38.9 8.5% (-43.4%, 60.4%) 286.6 0.834 (0.801, 0.861)
P05 P06 2.7 -1.3% (-25.5%, 23%) 97.9 0.975 (0.969, 0.979)
P07 17.6 3.5% (-31.5%, 38.5%) 178.7 0.918 (0.902, 0.932)
P08 2.1 0.6% (-24.6%, 25.8%) 102.0 0.977 (0.972, 0.981)
P09 16.3 2.5% (-40%, 44.9%) 205.6 0.899 (0.877, 0.917)
P10 18.0 2.8% (-43.9%, 49.5%) 220.9 0.891 (0.867, 0.911)
P06 P07 6.5 3% (-26%, 32.1%) 112.5 0.963 (0.954, 0.969)
P08 -4.3 1.2% (-25.5%, 27.9%) 104.0 0.972 (0.965, 0.977)
P09 -1.9 0.6% (-33.3%, 34.6%) 105.6 0.97 (0.963, 0.976)
P10 3.8 2% (-42.6%, 46.6%) 161.6 0.935 (0.919, 0.948)
P07 P08 -15.7 -2.8% (-39.3%, 33.7%) 167.1 0.928 (0.914, 0.94)
P09 -1.6 -1.1% (-35.3%, 33.2%) 128.1 0.956 (0.946, 0.964)
P10 -1.3 -0.4% (-45.6%, 44.8%) 184.3 0.915 (0.896, 0.932)
P08 P09 12.7 1.5% (-37.6%, 40.6%) 171.7 0.928 (0.912, 0.941)
P10 15.5 2.2% (-43.8%, 48.3%) 218.2 0.893 (0.87, 0.913)
P09 P10 -1.9 0.6% (-37.1%, 38.4%) 137.0 0.951 (0.939, 0.96)

3.0T

Table 8: Between-protocol reproducibility analysis of R2* by lobe in 3.0T.
Lobe Protocol x Protocol y Bias Bias (%) (LoA %) CR CCC (95% CI)
Left P01 P02 33.1 6.4% (-21.5%, 34.3%) 280.6 0.952 (0.946, 0.958)
P03 131.9 14.3% (-60.3%, 88.9%) 757.5 0.574 (0.524, 0.62)
P04 110.9 12.5% (-55.6%, 80.7%) 678.6 0.626 (0.593, 0.656)
P05 175.4 22% (-61.5%, 105.4%) 836.1 0.433 (0.38, 0.483)
P06 184.4 23.5% (-61.8%, 108.8%) 852.0 0.405 (0.352, 0.456)
P07 174.5 23.3% (-56.9%, 103.5%) 797.0 0.449 (0.398, 0.498)
P08 151.8 19.6% (-53.4%, 92.6%) 765.3 0.475 (0.44, 0.508)
P09 62.3 4.7% (-70%, 79.4%) 569.8 0.661 (0.606, 0.709)
P10 188.2 21.9% (-73.8%, 117.5%) 912.7 0.395 (0.332, 0.454)
P02 P03 79.2 6.6% (-60.6%, 73.7%) 646.3 0.635 (0.586, 0.68)
P04 67.0 5.2% (-55.2%, 65.5%) 562.5 0.708 (0.679, 0.734)
P05 117.1 13.6% (-60.1%, 87.3%) 681.0 0.544 (0.492, 0.592)
P06 135.7 16.9% (-63.8%, 97.5%) 725.9 0.473 (0.417, 0.525)
P07 118.0 14.9% (-55.5%, 85.3%) 670.3 0.535 (0.483, 0.583)
P08 114.2 13.1% (-58.7%, 84.9%) 676.9 0.523 (0.488, 0.557)
P09 14.6 -2.8% (-68.5%, 62.9%) 414.2 0.783 (0.742, 0.819)
P10 124.2 13.9% (-74.9%, 102.7%) 749.5 0.496 (0.432, 0.556)
P03 P04 7.3 1.3% (-49.2%, 51.8%) 267.7 0.9 (0.881, 0.916)
P05 42.3 8.2% (-41%, 57.3%) 272.6 0.874 (0.852, 0.893)
P06 58.9 11.8% (-50.3%, 73.9%) 320.7 0.819 (0.789, 0.845)
P07 55.0 11.3% (-45.5%, 68%) 320.4 0.818 (0.788, 0.844)
P08 35.0 7.8% (-36.1%, 51.8%) 221.3 0.917 (0.902, 0.929)
P09 5.5 -2.6% (-69.2%, 64%) 350.5 0.824 (0.787, 0.854)
P10 37.8 7.8% (-64.6%, 80.2%) 341.8 0.83 (0.796, 0.859)
P04 P05 36.1 7.4% (-44.1%, 58.8%) 240.8 0.897 (0.878, 0.913)
P06 50.7 10.4% (-43.7%, 64.4%) 259.4 0.872 (0.85, 0.891)
P07 47.5 10% (-41.2%, 61.3%) 245.8 0.884 (0.864, 0.901)
P08 38.9 7.4% (-37.4%, 52.2%) 265.2 0.87 (0.855, 0.883)
P09 -5.9 -4.3% (-66.1%, 57.4%) 284.0 0.875 (0.848, 0.897)
P10 25.9 6.1% (-64.1%, 76.3%) 293.6 0.868 (0.841, 0.891)
P05 P06 15.5 3.5% (-54.9%, 62%) 237.0 0.887 (0.865, 0.905)
P07 11.1 2.7% (-47.6%, 53%) 222.2 0.9 (0.881, 0.916)
P08 -4.3 0.3% (-46.7%, 47.2%) 200.1 0.925 (0.91, 0.937)
P09 -35.5 -10.4% (-76.4%, 55.6%) 315.3 0.823 (0.787, 0.854)
P10 -8.2 -1.6% (-63.9%, 60.8%) 297.1 0.851 (0.819, 0.877)
P06 P07 -3.7 -0.6% (-57%, 55.8%) 222.7 0.897 (0.877, 0.915)
P08 -19.9 -3.4% (-58.5%, 51.7%) 198.0 0.92 (0.905, 0.934)
P09 -52.5 -13.4% (-79%, 52.1%) 311.5 0.808 (0.771, 0.841)
P10 -25.0 -4.5% (-73%, 63.9%) 285.7 0.852 (0.821, 0.878)
P07 P08 -19.7 -3.6% (-51.5%, 44.2%) 209.1 0.911 (0.893, 0.925)
P09 -48.9 -13.2% (-72.9%, 46.5%) 259.9 0.864 (0.837, 0.887)
P10 -26.3 -5.4% (-66.3%, 55.5%) 265.1 0.871 (0.845, 0.894)
P08 P09 -30.0 -10.5% (-72.1%, 51%) 284.2 0.858 (0.828, 0.883)
P10 -2.3 -0.6% (-71.3%, 70%) 252.9 0.891 (0.867, 0.91)
P09 P10 18.2 6.2% (-55.1%, 67.4%) 273.5 0.879 (0.852, 0.901)
Right P01 P02 29.4 5.3% (-13.4%, 24.1%) 180.7 0.983 (0.981, 0.985)
P03 92.4 7.7% (-53.6%, 69.1%) 672.6 0.729 (0.685, 0.768)
P04 75.0 6.6% (-46.1%, 59.3%) 595.6 0.786 (0.761, 0.808)
P05 151.4 16.7% (-54.7%, 88.2%) 849.9 0.554 (0.499, 0.606)
P06 158.7 16.8% (-55.1%, 88.6%) 869.9 0.527 (0.47, 0.58)
P07 133.2 16.7% (-50.2%, 83.5%) 692.0 0.659 (0.611, 0.703)
P08 125.4 14% (-43.9%, 71.9%) 740.1 0.625 (0.591, 0.657)
P09 35.9 2.7% (-54.1%, 59.5%) 399.1 0.847 (0.814, 0.874)
P10 164.9 18.4% (-70.4%, 107.1%) 961.7 0.488 (0.416, 0.555)
P02 P03 57.1 1.9% (-53.8%, 57.7%) 627.7 0.733 (0.687, 0.773)
P04 38.9 0.5% (-47.8%, 48.8%) 520.1 0.82 (0.797, 0.84)
P05 99.7 9.9% (-51.4%, 71.3%) 699.5 0.635 (0.581, 0.682)
P06 113.5 11.3% (-56.9%, 79.5%) 721.2 0.607 (0.552, 0.657)
P07 86.3 9.9% (-46.7%, 66.5%) 601.5 0.711 (0.665, 0.752)
P08 94.1 8.7% (-47.6%, 65.1%) 663.4 0.662 (0.628, 0.693)
P09 -0.2 -2.9% (-52.6%, 46.7%) 281.0 0.913 (0.892, 0.93)
P10 116.3 12.7% (-75%, 100.4%) 853.0 0.536 (0.461, 0.604)
P03 P04 2.2 1.1% (-35.7%, 37.9%) 196.2 0.965 (0.957, 0.972)
P05 47.3 9.1% (-29.8%, 48%) 289.9 0.91 (0.892, 0.925)
P06 64.1 10.6% (-38%, 59.3%) 345.6 0.867 (0.842, 0.889)
P07 54.4 10.7% (-36.7%, 58.2%) 308.0 0.898 (0.877, 0.915)
P08 43.7 8.2% (-28.4%, 44.8%) 287.8 0.907 (0.889, 0.922)
P09 24.1 2.1% (-53.8%, 58.1%) 375.9 0.854 (0.821, 0.882)
P10 56.4 12.2% (-58.2%, 82.7%) 432.8 0.832 (0.794, 0.863)
P04 P05 45.1 8.7% (-35.3%, 52.7%) 234.3 0.935 (0.921, 0.946)
P06 58.0 9.6% (-40.8%, 60%) 281.8 0.903 (0.884, 0.919)
P07 47.7 9.4% (-36.9%, 55.7%) 215.9 0.943 (0.932, 0.953)
P08 49.2 7.9% (-30.1%, 46%) 272.9 0.913 (0.902, 0.923)
P09 19.8 0.5% (-58.1%, 59.1%) 321.4 0.889 (0.863, 0.91)
P10 44.7 10.4% (-57.3%, 78%) 302.6 0.909 (0.888, 0.927)
P05 P06 15.9 1.9% (-45.6%, 49.4%) 242.4 0.926 (0.91, 0.94)
P07 6.4 1.7% (-39.7%, 43.1%) 228.2 0.938 (0.924, 0.95)
P08 0.6 -0.1% (-34.9%, 34.6%) 199.0 0.95 (0.939, 0.96)
P09 -15.6 -5.4% (-61.5%, 50.6%) 318.0 0.878 (0.848, 0.903)
P10 2.6 3.4% (-64.2%, 71.1%) 353.4 0.871 (0.84, 0.897)
P06 P07 -10.3 -0.6% (-52.1%, 51%) 274.8 0.908 (0.887, 0.925)
P08 -15.0 -1.9% (-48.6%, 44.7%) 237.8 0.926 (0.909, 0.94)
P09 -32.0 -7.6% (-67.4%, 52.1%) 298.2 0.885 (0.857, 0.908)
P10 -11.7 2.4% (-69.3%, 74%) 324.2 0.889 (0.862, 0.911)
P07 P08 -10.8 -2.1% (-42.7%, 38.5%) 226.0 0.934 (0.919, 0.946)
P09 -25.1 -7.4% (-64.3%, 49.6%) 314.1 0.876 (0.846, 0.901)
P10 -5.9 1% (-63.4%, 65.3%) 292.0 0.914 (0.892, 0.931)
P08 P09 -16.9 -5.9% (-59.5%, 47.7%) 310.2 0.881 (0.852, 0.905)
P10 16.7 6.1% (-64.3%, 76.5%) 337.0 0.866 (0.834, 0.892)
P09 P10 16.5 5.3% (-42.6%, 53.3%) 229.6 0.936 (0.919, 0.949)

By segment

The between-protocol bias, coefficient of reproducibility (CR), concordance correlation coefficient (CCC) and 95% confidence interval (CI) are summarized by segment for 1.5T and 3.0 T in Table 9 and Table 10, respectively.

CCC heatmap

Pairwise CCC is visualized in Figure 10 below.

Figure 11: Pairwise CCC for between-protocol reproducibility by segment.

1.5T

Table 9: Between-protocol reproducibility analysis of R2* by segment in 1.5T.
Segment Protocol x Protocol y Bias Bias (%) (LoA %) CR CCC (95% CI)
I P01 P02 16.0 5.8% (-19.7%, 31.3%) 101.6 0.978 (0.973, 0.983)
P03 46.1 10.1% (-42.5%, 62.8%) 394.7 0.694 (0.592, 0.774)
P04 32.8 6.8% (-37.1%, 50.6%) 274.0 0.823 (0.781, 0.858)
P05 62.9 16.5% (-34.5%, 67.5%) 380.4 0.683 (0.592, 0.757)
P06 49.8 14.2% (-30.9%, 59.2%) 277.9 0.758 (0.685, 0.815)
P07 71.7 17.2% (-39.6%, 74%) 430.2 0.576 (0.471, 0.665)
P08 47.3 13.1% (-32.1%, 58.3%) 310.3 0.762 (0.709, 0.806)
P09 73.6 12.7% (-57.6%, 82.9%) 484.6 0.508 (0.379, 0.618)
P10 75.5 15.1% (-49.8%, 79.9%) 473.3 0.566 (0.442, 0.669)
P02 P03 25.2 3.2% (-48.4%, 54.7%) 298.7 0.792 (0.711, 0.852)
P04 16.5 0.8% (-42.8%, 44.3%) 207.0 0.885 (0.854, 0.91)
P05 44.1 9.5% (-43.4%, 62.3%) 282.9 0.783 (0.711, 0.839)
P06 32.0 6.8% (-39.5%, 53.1%) 178.3 0.874 (0.831, 0.907)
P07 54.4 11.1% (-48.2%, 70.3%) 344.6 0.659 (0.56, 0.739)
P08 31.6 7.3% (-36.7%, 51.3%) 251.9 0.818 (0.772, 0.855)
P09 50.7 6% (-63.4%, 75.3%) 377.6 0.633 (0.515, 0.728)
P10 51.1 7.7% (-57.8%, 73.3%) 367.3 0.673 (0.56, 0.761)
P03 P04 1.5 -0.3% (-42.5%, 41.9%) 159.0 0.93 (0.898, 0.953)
P05 21.2 7% (-30.5%, 44.5%) 138.9 0.935 (0.908, 0.954)
P06 32.4 7.2% (-36.1%, 50.4%) 186.4 0.862 (0.814, 0.899)
P07 31.2 8.2% (-36.6%, 53.1%) 202.8 0.85 (0.795, 0.891)
P08 21.2 6.5% (-33.6%, 46.6%) 181.4 0.892 (0.847, 0.924)
P09 27.6 4.5% (-46.8%, 55.9%) 177.7 0.89 (0.847, 0.922)
P10 23.7 5.6% (-27.3%, 38.6%) 140.2 0.937 (0.911, 0.956)
P04 P05 19.5 7.1% (-25.5%, 39.7%) 136.3 0.936 (0.909, 0.955)
P06 26.6 7.8% (-32.9%, 48.5%) 159.9 0.889 (0.847, 0.921)
P07 29.4 8.5% (-37.5%, 54.4%) 192.0 0.861 (0.809, 0.899)
P08 18.2 7% (-31.9%, 45.9%) 163.0 0.906 (0.878, 0.927)
P09 33.6 6.5% (-52.3%, 65.2%) 224.5 0.828 (0.759, 0.879)
P10 24.7 5.8% (-45.9%, 57.6%) 208.3 0.865 (0.805, 0.908)
P05 P06 12.1 1.6% (-37.4%, 40.6%) 125.6 0.926 (0.892, 0.95)
P07 10.9 1.6% (-47.2%, 50.4%) 168.1 0.881 (0.829, 0.918)
P08 1.2 0% (-46.1%, 46.1%) 149.8 0.916 (0.876, 0.943)
P09 8.9 -2.3% (-59.4%, 54.8%) 165.4 0.893 (0.841, 0.929)
P10 6.5 -0.6% (-42.8%, 41.5%) 120.6 0.95 (0.924, 0.968)
P06 P07 -5.4 -0.7% (-45.8%, 44.4%) 141.9 0.896 (0.847, 0.93)
P08 -12.9 -1.2% (-40.6%, 38.3%) 144.9 0.904 (0.861, 0.935)
P09 -1.8 -3% (-42.9%, 36.9%) 65.4 0.98 (0.969, 0.987)
P10 -11.0 -2.9% (-50.2%, 44.3%) 146.6 0.91 (0.862, 0.941)
P07 P08 -10.9 -2.3% (-45.3%, 40.7%) 165.3 0.884 (0.833, 0.921)
P09 0.7 -2% (-59%, 54.9%) 172.9 0.873 (0.811, 0.916)
P10 -5.8 -2% (-45.3%, 41.2%) 143.1 0.921 (0.881, 0.949)
P08 P09 4.8 -2.1% (-52.7%, 48.5%) 146.3 0.914 (0.87, 0.943)
P10 5.6 -0.2% (-43.7%, 43.4%) 150.0 0.923 (0.882, 0.95)
P09 P10 -7.5 -0.8% (-46.3%, 44.8%) 122.4 0.937 (0.905, 0.959)
II P01 P02 15.7 5.1% (-24.9%, 35.1%) 109.6 0.975 (0.968, 0.98)
P03 39.7 7.5% (-43.2%, 58.2%) 309.2 0.804 (0.733, 0.858)
P04 22.6 6.2% (-26.8%, 39.2%) 162.9 0.941 (0.926, 0.953)
P05 64.5 16.7% (-30.2%, 63.5%) 318.4 0.752 (0.684, 0.807)
P06 40.8 14.6% (-19.9%, 49%) 158.7 0.915 (0.89, 0.935)
P07 61.9 17.4% (-27.2%, 62%) 294.7 0.787 (0.729, 0.835)
P08 44.1 12% (-31.1%, 55%) 245.5 0.85 (0.816, 0.878)
P09 57.3 12.4% (-47.6%, 72.4%) 372.8 0.699 (0.598, 0.779)
P10 67.0 17.6% (-42.8%, 78%) 403.6 0.684 (0.572, 0.77)
P02 P03 19.0 0.8% (-49.5%, 51%) 242.0 0.865 (0.808, 0.906)
P04 6.1 0.7% (-35.2%, 36.7%) 122.2 0.963 (0.952, 0.972)
P05 46.3 10.1% (-35.3%, 55.6%) 234.3 0.837 (0.787, 0.877)
P06 28.7 7.8% (-29.1%, 44.7%) 134.7 0.937 (0.916, 0.953)
P07 45.9 11.8% (-34%, 57.6%) 218.4 0.858 (0.814, 0.893)
P08 28.5 6.9% (-39%, 52.9%) 181.8 0.904 (0.879, 0.925)
P09 34.6 4.9% (-59.1%, 68.9%) 290.2 0.788 (0.703, 0.851)
P10 46.1 10.4% (-53.4%, 74.3%) 326.8 0.756 (0.658, 0.829)
P03 P04 -12.9 0% (-48.6%, 48.6%) 221.5 0.883 (0.832, 0.92)
P05 28.2 9.5% (-40.3%, 59.2%) 210.8 0.853 (0.794, 0.896)
P06 21.0 9% (-28.8%, 46.8%) 135.3 0.937 (0.909, 0.956)
P07 27.9 10.7% (-44.5%, 66%) 231.7 0.827 (0.757, 0.878)
P08 21.7 7.8% (-39.7%, 55.3%) 173.4 0.909 (0.869, 0.937)
P09 15.8 4.8% (-35.6%, 45.1%) 115.5 0.96 (0.943, 0.973)
P10 18.3 7.5% (-35.7%, 50.7%) 159.3 0.933 (0.899, 0.956)
P04 P05 39.2 9.2% (-30.6%, 49.1%) 192.4 0.882 (0.843, 0.912)
P06 26.3 7.2% (-21.4%, 35.9%) 128.9 0.943 (0.924, 0.958)
P07 40.5 10.9% (-34.6%, 56.4%) 197.2 0.879 (0.837, 0.91)
P08 25.8 7.1% (-36.5%, 50.6%) 182.2 0.898 (0.87, 0.921)
P09 31.0 4.1% (-56.9%, 65%) 262.8 0.82 (0.745, 0.875)
P10 38.2 8.9% (-50.8%, 68.6%) 272.7 0.825 (0.748, 0.88)
P05 P06 -2.7 0.4% (-29.9%, 30.7%) 102.6 0.959 (0.938, 0.973)
P07 0.2 1.6% (-38.1%, 41.2%) 120.1 0.944 (0.917, 0.963)
P08 -5.8 -1.5% (-54%, 50.9%) 191.6 0.87 (0.812, 0.911)
P09 -14.8 -6.2% (-68.2%, 55.8%) 207.6 0.847 (0.774, 0.898)
P10 -10.0 -2% (-58.4%, 54.4%) 221.3 0.851 (0.778, 0.901)
P06 P07 6.6 2.2% (-37.7%, 42.1%) 128.6 0.932 (0.9, 0.954)
P08 -4.2 -2.3% (-35.9%, 31.2%) 113.0 0.955 (0.933, 0.97)
P09 -5.5 -5.5% (-51.1%, 40%) 147.5 0.924 (0.884, 0.951)
P10 -3.6 -0.5% (-44%, 42.9%) 153.6 0.929 (0.891, 0.954)
P07 P08 -6.5 -3.2% (-54%, 47.6%) 173.9 0.895 (0.847, 0.928)
P09 -12.8 -7.4% (-71.3%, 56.5%) 216.5 0.838 (0.762, 0.892)
P10 -4.8 -1.1% (-62.3%, 60.1%) 229.9 0.843 (0.766, 0.896)
P08 P09 -8.1 -3.4% (-59.8%, 53%) 192.5 0.881 (0.822, 0.921)
P10 0.2 0.5% (-50.3%, 51.2%) 185.0 0.906 (0.857, 0.939)
P09 P10 1.4 3.7% (-49%, 56.4%) 154.5 0.927 (0.89, 0.952)
III P01 P02 10.9 5.8% (-20.7%, 32.3%) 87.3 0.986 (0.982, 0.989)
P03 34.1 7.9% (-27.8%, 43.6%) 265.1 0.868 (0.818, 0.904)
P04 19.5 5.3% (-26.2%, 36.8%) 174.7 0.939 (0.922, 0.952)
P05 49.9 14.1% (-28.8%, 57%) 332.7 0.783 (0.705, 0.842)
P06 34.2 11.3% (-26.7%, 49.3%) 210.0 0.882 (0.836, 0.916)
P07 51.4 13.3% (-25.6%, 52.2%) 309.4 0.801 (0.737, 0.852)
P08 40.3 10.9% (-26.2%, 47.9%) 225.5 0.882 (0.856, 0.904)
P09 61.9 15.4% (-44.2%, 74.9%) 412.1 0.668 (0.555, 0.757)
P10 77.8 16.8% (-47%, 80.7%) 452.8 0.606 (0.484, 0.704)
P02 P03 26.7 2% (-37.6%, 41.5%) 245.0 0.884 (0.84, 0.916)
P04 9.1 -0.4% (-30.4%, 29.6%) 142.1 0.958 (0.946, 0.967)
P05 43.1 9.1% (-35.1%, 53.3%) 285.4 0.832 (0.772, 0.877)
P06 25.4 4.8% (-33.1%, 42.7%) 178.1 0.913 (0.879, 0.938)
P07 42.7 7.4% (-34%, 48.8%) 274.6 0.839 (0.786, 0.879)
P08 28.8 4.9% (-29.4%, 39.1%) 197.1 0.906 (0.885, 0.924)
P09 52.0 8.5% (-54.7%, 71.7%) 385.9 0.696 (0.59, 0.779)
P10 67.2 9.8% (-56.3%, 75.8%) 428.7 0.633 (0.516, 0.726)
P03 P04 -10.8 -1.5% (-29.3%, 26.3%) 133.8 0.96 (0.943, 0.973)
P05 16.5 7.2% (-27.5%, 41.9%) 143.6 0.947 (0.922, 0.964)
P06 17.7 5.2% (-27.9%, 38.4%) 119.5 0.957 (0.938, 0.97)
P07 17.1 5.7% (-27%, 38.5%) 136.0 0.949 (0.927, 0.965)
P08 15.1 6.4% (-25.7%, 38.6%) 137.1 0.95 (0.928, 0.966)
P09 28.4 8.8% (-41.8%, 59.5%) 173.7 0.918 (0.88, 0.944)
P10 39.0 10% (-40.6%, 60.7%) 201.5 0.887 (0.838, 0.921)
P04 P05 27.7 8.9% (-22.9%, 40.8%) 138.9 0.95 (0.93, 0.965)
P06 23.9 6.2% (-27.8%, 40.3%) 153.9 0.932 (0.903, 0.952)
P07 27.8 7.3% (-24.7%, 39.3%) 148.4 0.941 (0.92, 0.957)
P08 22.5 5.9% (-23.3%, 35.2%) 132.5 0.95 (0.937, 0.96)
P09 35.5 9.1% (-45.2%, 63.4%) 247.0 0.848 (0.783, 0.894)
P10 49.5 10.4% (-46.2%, 67%) 294.3 0.788 (0.705, 0.849)
P05 P06 1.5 -1.7% (-30.2%, 26.7%) 93.2 0.974 (0.96, 0.983)
P07 0.8 -1.4% (-34.4%, 31.5%) 146.2 0.942 (0.914, 0.961)
P08 -2.0 -1.6% (-36.5%, 33.4%) 149.2 0.941 (0.913, 0.96)
P09 8.6 0.1% (-41.7%, 42%) 187.4 0.904 (0.855, 0.936)
P10 22.0 2.3% (-45.6%, 50.1%) 226.7 0.86 (0.795, 0.906)
P06 P07 0.2 0.7% (-35.1%, 36.5%) 124.6 0.95 (0.925, 0.966)
P08 0.4 1.9% (-29.9%, 33.8%) 115.6 0.958 (0.937, 0.973)
P09 -0.3 1.3% (-40.5%, 43.2%) 114.0 0.961 (0.939, 0.975)
P10 9.2 2.1% (-36.1%, 40.2%) 150.7 0.931 (0.894, 0.956)
P07 P08 -1.7 0.6% (-33.5%, 34.8%) 122.4 0.958 (0.937, 0.972)
P09 8.3 2.7% (-45%, 50.3%) 178.7 0.908 (0.862, 0.94)
P10 16.4 3.2% (-46.8%, 53.2%) 202.0 0.88 (0.82, 0.921)
P08 P09 6.8 1.3% (-51.4%, 54.1%) 184.1 0.902 (0.853, 0.936)
P10 20.7 2.7% (-57.4%, 62.8%) 246.4 0.83 (0.75, 0.887)
P09 P10 5.4 0.1% (-38.2%, 38.4%) 99.7 0.97 (0.954, 0.98)
IVA P01 P02 13.1 6.3% (-15.1%, 27.7%) 61.8 0.993 (0.991, 0.994)
P03 43.3 9.8% (-30.2%, 49.7%) 252.5 0.879 (0.839, 0.91)
P04 24.3 7.3% (-22.6%, 37.2%) 167.0 0.943 (0.929, 0.955)
P05 52.7 14.2% (-24.9%, 53.3%) 267.3 0.857 (0.813, 0.891)
P06 30.7 9.2% (-23.4%, 41.9%) 161.9 0.938 (0.916, 0.954)
P07 55.5 15.3% (-23.8%, 54.5%) 280.7 0.843 (0.793, 0.882)
P08 38.0 10.8% (-22.6%, 44.1%) 215.1 0.9 (0.877, 0.919)
P09 57.5 13.6% (-30%, 57.3%) 302.4 0.82 (0.763, 0.865)
P10 63.8 15.3% (-46.1%, 76.7%) 409.1 0.718 (0.616, 0.796)
P02 P03 27.2 2.7% (-40.8%, 46.2%) 246.7 0.882 (0.838, 0.915)
P04 12.4 0.9% (-30.8%, 32.6%) 164.1 0.944 (0.928, 0.956)
P05 36.4 7% (-35.7%, 49.7%) 258.0 0.863 (0.816, 0.9)
P06 16.5 2.3% (-32.1%, 36.6%) 130.2 0.959 (0.942, 0.97)
P07 42.5 9% (-35%, 53%) 274.2 0.843 (0.789, 0.885)
P08 25.9 4.8% (-31.3%, 41%) 205.7 0.906 (0.882, 0.926)
P09 40.6 5.6% (-42.8%, 54%) 290.5 0.828 (0.766, 0.875)
P10 47.3 7.2% (-57.6%, 72%) 398.5 0.717 (0.61, 0.799)
P03 P04 -11.4 -1.2% (-30.6%, 28.1%) 115.7 0.97 (0.957, 0.979)
P05 8.2 4% (-21.1%, 29%) 66.3 0.989 (0.983, 0.992)
P06 10.3 1.9% (-30.8%, 34.5%) 131.7 0.954 (0.932, 0.969)
P07 15.0 6.1% (-24.2%, 36.3%) 110.2 0.968 (0.953, 0.978)
P08 6.2 3.3% (-24.7%, 31.2%) 95.9 0.978 (0.968, 0.985)
P09 11.8 3.8% (-22.3%, 29.9%) 85.2 0.981 (0.971, 0.987)
P10 14.8 4.9% (-47.7%, 57.4%) 185.1 0.922 (0.881, 0.949)
P04 P05 19.1 5.7% (-20.6%, 31.9%) 116.9 0.967 (0.953, 0.976)
P06 20.0 3.6% (-33%, 40.2%) 174.7 0.922 (0.887, 0.947)
P07 26.3 7.4% (-17.1%, 31.9%) 126.3 0.959 (0.942, 0.97)
P08 15.0 4.1% (-19.7%, 27.9%) 109.6 0.969 (0.96, 0.976)
P09 21.6 3.6% (-30.4%, 37.7%) 143.6 0.95 (0.929, 0.965)
P10 29.2 6.1% (-46.3%, 58.5%) 234.6 0.884 (0.831, 0.921)
P05 P06 3.1 -2.1% (-41.6%, 37.4%) 155.1 0.935 (0.902, 0.957)
P07 7.0 1.8% (-28.3%, 31.9%) 122.8 0.961 (0.942, 0.974)
P08 -3.0 -1.4% (-30.8%, 28.1%) 109.1 0.972 (0.958, 0.981)
P09 2.7 -0.7% (-30.6%, 29.1%) 91.4 0.978 (0.967, 0.986)
P10 5.5 -0.6% (-54.1%, 53%) 197.9 0.909 (0.861, 0.941)
P06 P07 0.8 2.8% (-33.6%, 39.2%) 132.7 0.951 (0.927, 0.967)
P08 -6.4 0.6% (-32.9%, 34.1%) 122.2 0.962 (0.943, 0.974)
P09 -1.5 -0.4% (-41.2%, 40.4%) 165.4 0.926 (0.886, 0.952)
P10 -2.0 0.1% (-37.8%, 37.9%) 148.2 0.947 (0.917, 0.966)
P07 P08 -8.1 -2.7% (-28.1%, 22.6%) 98.4 0.976 (0.965, 0.984)
P09 -3.3 -3.3% (-31.4%, 24.9%) 93.7 0.978 (0.966, 0.985)
P10 0.1 -0.9% (-55.6%, 53.8%) 157.2 0.943 (0.912, 0.963)
P08 P09 3.4 -0.3% (-35.3%, 34.6%) 137.5 0.954 (0.931, 0.97)
P10 11.3 2.1% (-51.9%, 56%) 199.1 0.914 (0.87, 0.943)
P09 P10 -0.1 1.7% (-50.7%, 54.2%) 154.8 0.939 (0.907, 0.96)
IVB P01 P02 10.9 5% (-14%, 23.9%) 65.5 0.992 (0.989, 0.994)
P03 23.6 6% (-22.4%, 34.4%) 230.3 0.905 (0.867, 0.933)
P04 14.4 4.4% (-22.4%, 31.2%) 152.7 0.955 (0.941, 0.965)
P05 41.1 10.7% (-16.9%, 38.2%) 242.2 0.88 (0.84, 0.911)
P06 31.9 10.4% (-16.9%, 37.6%) 139.5 0.937 (0.915, 0.954)
P07 43.3 11.4% (-24.4%, 47.1%) 304.6 0.817 (0.75, 0.867)
P08 32.7 10.5% (-18.4%, 39.3%) 184.9 0.923 (0.904, 0.938)
P09 48.3 10.8% (-40.2%, 61.8%) 382.9 0.72 (0.614, 0.801)
P10 55.7 11.9% (-41.2%, 65%) 413.7 0.69 (0.578, 0.777)
P02 P03 19.4 1.8% (-31.3%, 34.8%) 241.4 0.896 (0.854, 0.927)
P04 3.8 -0.6% (-26.3%, 25.1%) 164.4 0.947 (0.931, 0.96)
P05 35.3 6.3% (-24%, 36.6%) 254.9 0.87 (0.826, 0.904)
P06 23.5 4.9% (-27%, 36.8%) 156.0 0.927 (0.898, 0.947)
P07 36.4 6.7% (-30.4%, 43.8%) 293.9 0.831 (0.77, 0.878)
P08 23.5 5.9% (-23.1%, 34.9%) 186.0 0.922 (0.902, 0.938)
P09 44.0 6.4% (-47.4%, 60.2%) 389.0 0.716 (0.61, 0.797)
P10 48.8 7.3% (-47.1%, 61.6%) 409.8 0.693 (0.582, 0.779)
P03 P04 -7.6 -1.7% (-23.6%, 20.2%) 110.5 0.976 (0.965, 0.984)
P05 18.8 4.5% (-19.4%, 28.3%) 119.1 0.965 (0.951, 0.975)
P06 29.0 6.3% (-30.9%, 43.5%) 185.2 0.9 (0.862, 0.928)
P07 19.2 5.5% (-24.7%, 35.7%) 142.0 0.952 (0.931, 0.967)
P08 16.1 6% (-20.8%, 32.8%) 117.2 0.968 (0.954, 0.978)
P09 30.2 6.3% (-41.2%, 53.8%) 221.4 0.884 (0.831, 0.921)
P10 33.8 7.1% (-40.4%, 54.5%) 216.2 0.893 (0.846, 0.926)
P04 P05 26.4 6.3% (-14.2%, 26.7%) 114.6 0.966 (0.955, 0.975)
P06 29.7 6.8% (-27.8%, 41.5%) 185.2 0.899 (0.861, 0.927)
P07 26.6 7% (-23.4%, 37.4%) 180.4 0.926 (0.895, 0.948)
P08 20.8 6.6% (-17.9%, 31.1%) 132.1 0.956 (0.944, 0.965)
P09 36.5 7.3% (-41.2%, 55.9%) 259.9 0.847 (0.78, 0.894)
P10 37.6 7.5% (-41.6%, 56.6%) 278.7 0.832 (0.761, 0.883)
P05 P06 12.1 2.3% (-28.7%, 33.4%) 125.2 0.949 (0.925, 0.965)
P07 0.9 1.1% (-29.2%, 31.5%) 134.8 0.954 (0.932, 0.969)
P08 -3.0 0.8% (-25.2%, 26.8%) 106.6 0.972 (0.958, 0.981)
P09 10.0 2.4% (-41.7%, 46.6%) 187.8 0.906 (0.858, 0.938)
P10 11.5 2.2% (-44.9%, 49.3%) 207.5 0.893 (0.837, 0.93)
P06 P07 -11.8 -1.2% (-35.2%, 32.8%) 144.9 0.932 (0.902, 0.954)
P08 -14.0 -0.6% (-34.7%, 33.5%) 124.0 0.952 (0.931, 0.966)
P09 -7.5 -2% (-32%, 28%) 114.0 0.96 (0.939, 0.973)
P10 -13.2 -3.1% (-39.4%, 33.1%) 130.8 0.949 (0.922, 0.967)
P07 P08 -2.8 0.5% (-32%, 33.1%) 130.7 0.958 (0.938, 0.972)
P09 8.6 0.3% (-37.9%, 38.5%) 165.2 0.93 (0.894, 0.954)
P10 8.5 0.7% (-36.7%, 38%) 142.3 0.95 (0.924, 0.967)
P08 P09 11.4 -0.6% (-49.4%, 48.3%) 198.6 0.902 (0.852, 0.935)
P10 14.7 0.3% (-48%, 48.5%) 196.1 0.908 (0.862, 0.939)
P09 P10 -1.6 0.2% (-31.4%, 31.9%) 116.1 0.964 (0.944, 0.976)
V P01 P02 11.5 5.6% (-9.3%, 20.4%) 49.2 0.996 (0.994, 0.996)
P03 34.9 6.1% (-21.5%, 33.7%) 264.3 0.884 (0.847, 0.913)
P04 14.9 3.7% (-15.5%, 22.9%) 152.6 0.96 (0.949, 0.968)
P05 43.5 10.5% (-14.9%, 36%) 284.3 0.864 (0.819, 0.898)
P06 30.0 9.4% (-13.5%, 32.3%) 127.3 0.952 (0.937, 0.964)
P07 58.3 12.4% (-32%, 56.9%) 417.3 0.696 (0.601, 0.772)
P08 35.5 10.1% (-13.5%, 33.8%) 222.8 0.902 (0.88, 0.921)
P09 54.8 8.9% (-39.8%, 57.6%) 435.0 0.681 (0.579, 0.762)
P10 70.8 12.8% (-51.7%, 77.3%) 535.9 0.552 (0.414, 0.666)
P02 P03 23.2 -0.1% (-33.1%, 32.9%) 249.0 0.897 (0.861, 0.924)
P04 3.6 -2.2% (-21.8%, 17.4%) 130.7 0.97 (0.962, 0.977)
P05 32.9 4.7% (-25.1%, 34.6%) 258.9 0.885 (0.846, 0.914)
P06 18.0 3.1% (-24.6%, 30.9%) 123.8 0.957 (0.942, 0.969)
P07 47.9 6.9% (-39.9%, 53.7%) 388.4 0.728 (0.64, 0.798)
P08 24.4 4.1% (-20.5%, 28.6%) 197.4 0.922 (0.903, 0.937)
P09 48.1 4.4% (-50%, 58.8%) 422.6 0.686 (0.584, 0.767)
P10 56.6 7.1% (-61.1%, 75.4%) 512.4 0.564 (0.423, 0.678)
P03 P04 -8.6 -0.9% (-20.8%, 19%) 141.1 0.961 (0.944, 0.973)
P05 11.8 4.3% (-16.1%, 24.7%) 135.8 0.959 (0.94, 0.972)
P06 13.0 4.4% (-16.3%, 25%) 88.5 0.977 (0.966, 0.984)
P07 25.6 7.3% (-30.4%, 44.9%) 224.3 0.879 (0.826, 0.916)
P08 14.2 6.3% (-17.1%, 29.8%) 129.7 0.961 (0.943, 0.974)
P09 25.8 5.5% (-37.2%, 48.1%) 235.2 0.866 (0.806, 0.908)
P10 33.1 8.2% (-47.6%, 63.9%) 269.8 0.833 (0.756, 0.887)
P04 P05 21.0 5.7% (-10.1%, 21.5%) 114.3 0.971 (0.96, 0.979)
P06 18.2 5.3% (-13.6%, 24.2%) 104.5 0.969 (0.956, 0.978)
P07 34.2 8.2% (-27.4%, 43.9%) 228.0 0.882 (0.836, 0.917)
P08 19.8 6.2% (-10.4%, 22.8%) 91.7 0.979 (0.974, 0.983)
P09 33.6 5.8% (-37.6%, 49.1%) 264.8 0.843 (0.78, 0.889)
P10 41.9 8.8% (-52%, 69.7%) 361.0 0.73 (0.622, 0.811)
P05 P06 3.3 0.4% (-15%, 15.9%) 58.6 0.99 (0.985, 0.993)
P07 14.4 3% (-32.3%, 38.3%) 209.4 0.893 (0.845, 0.927)
P08 2.7 1.3% (-15.3%, 18%) 89.9 0.982 (0.972, 0.988)
P09 16.4 1.3% (-38.1%, 40.7%) 225.0 0.877 (0.819, 0.917)
P10 22.4 3.6% (-54.5%, 61.7%) 288.2 0.808 (0.718, 0.872)
P06 P07 -2.7 0.2% (-20.9%, 21.3%) 106.7 0.968 (0.952, 0.978)
P08 -2.5 1.4% (-22.2%, 24.9%) 82.2 0.981 (0.971, 0.987)
P09 -5.9 -2.8% (-29.4%, 23.7%) 109.2 0.966 (0.948, 0.979)
P10 2.5 0.1% (-44.8%, 45.1%) 179.2 0.915 (0.868, 0.945)
P07 P08 -11.3 -1.2% (-34.8%, 32.4%) 148.9 0.945 (0.919, 0.963)
P09 -3.8 -3.1% (-31.4%, 25.1%) 116.8 0.963 (0.944, 0.976)
P10 5.3 0.3% (-50.1%, 50.6%) 267.8 0.824 (0.738, 0.883)
P08 P09 11.0 -1.1% (-43.1%, 40.9%) 186.4 0.913 (0.871, 0.942)
P10 18.3 1.5% (-58.1%, 61.1%) 289.3 0.803 (0.711, 0.869)
P09 P10 5.2 3.3% (-39.4%, 46.1%) 187.4 0.905 (0.857, 0.938)
VI P01 P02 14.3 6.9% (-19.6%, 33.3%) 51.6 0.995 (0.994, 0.996)
P03 36.0 7.3% (-31.4%, 45.9%) 321.6 0.845 (0.786, 0.889)
P04 20.5 4.4% (-21.2%, 29.9%) 160.6 0.954 (0.943, 0.963)
P05 53.0 14.1% (-14.5%, 42.8%) 277.9 0.867 (0.827, 0.899)
P06 34.2 11.2% (-14.9%, 37.2%) 160.5 0.937 (0.917, 0.953)
P07 66.3 14.7% (-28.1%, 57.6%) 370.1 0.753 (0.683, 0.81)
P08 38.0 10.3% (-21%, 41.6%) 262.3 0.87 (0.839, 0.896)
P09 68.1 13.4% (-41.4%, 68.1%) 449.6 0.662 (0.556, 0.748)
P10 77.4 14.8% (-43.6%, 73.2%) 467.1 0.658 (0.552, 0.743)
P02 P03 18.1 -1.5% (-49%, 46%) 316.6 0.845 (0.782, 0.89)
P04 5.6 -3% (-28.6%, 22.6%) 148.4 0.961 (0.95, 0.969)
P05 34.5 4.6% (-34.9%, 44%) 259.7 0.883 (0.844, 0.913)
P06 16.4 2.3% (-40%, 44.6%) 150.3 0.946 (0.923, 0.962)
P07 49.2 6.5% (-41.2%, 54.3%) 346.5 0.774 (0.704, 0.829)
P08 23.0 2.6% (-31.9%, 37.2%) 246.4 0.883 (0.852, 0.908)
P09 52.9 5.1% (-55.9%, 66.2%) 433.6 0.674 (0.567, 0.759)
P10 58.0 6.2% (-57.1%, 69.4%) 435.5 0.684 (0.579, 0.766)
P03 P04 -5.5 -1.6% (-31.5%, 28.3%) 150.1 0.959 (0.94, 0.973)
P05 15.8 6% (-25.7%, 37.6%) 168.9 0.942 (0.916, 0.961)
P06 19.4 4.9% (-16.6%, 26.3%) 101.0 0.975 (0.966, 0.982)
P07 32.2 7.8% (-14.6%, 30.2%) 140.7 0.949 (0.932, 0.961)
P08 13.7 5% (-29.7%, 39.8%) 162.0 0.948 (0.924, 0.964)
P09 30.5 7.1% (-30.5%, 44.7%) 167.2 0.932 (0.903, 0.952)
P10 38.0 7.1% (-46.2%, 60.4%) 286.8 0.827 (0.754, 0.88)
P04 P05 21.4 7.3% (-9.7%, 24.4%) 85.2 0.983 (0.976, 0.987)
P06 16.6 6.5% (-24%, 37%) 102.4 0.974 (0.963, 0.982)
P07 37.6 9.9% (-19.3%, 39.1%) 181.8 0.918 (0.888, 0.94)
P08 17.7 5.8% (-16.5%, 28.1%) 123.4 0.965 (0.955, 0.973)
P09 39.4 9.1% (-35.9%, 54%) 243.0 0.867 (0.812, 0.906)
P10 44.5 9.8% (-38.2%, 57.8%) 271.8 0.842 (0.777, 0.889)
P05 P06 -2.0 -2.3% (-25.7%, 21.2%) 99.8 0.975 (0.963, 0.984)
P07 16.7 2.3% (-29.8%, 34.5%) 162.1 0.934 (0.905, 0.955)
P08 -1.4 -0.7% (-26.1%, 24.7%) 103.0 0.978 (0.967, 0.985)
P09 19.1 2.3% (-42.7%, 47.4%) 208.8 0.896 (0.846, 0.93)
P10 22.3 2.6% (-45.2%, 50.5%) 225.8 0.883 (0.828, 0.922)
P06 P07 8.5 1.4% (-27.2%, 30.1%) 99.3 0.973 (0.96, 0.982)
P08 -6.0 -0.1% (-21.6%, 21.5%) 111.4 0.971 (0.956, 0.981)
P09 1.7 -1.2% (-32.4%, 29.9%) 67.0 0.988 (0.982, 0.993)
P10 17.2 1.5% (-44.6%, 47.6%) 206.5 0.894 (0.841, 0.93)
P07 P08 -18.7 -3.2% (-35.3%, 28.9%) 151.7 0.942 (0.918, 0.96)
P09 1.0 -0.7% (-32.9%, 31.5%) 113.0 0.966 (0.948, 0.978)
P10 3.8 -0.4% (-47%, 46.1%) 183.0 0.915 (0.87, 0.945)
P08 P09 19.2 2.8% (-31.4%, 37.1%) 158.1 0.939 (0.911, 0.959)
P10 24.3 3.2% (-36.5%, 42.9%) 209.5 0.9 (0.853, 0.932)
P09 P10 -3.6 -1% (-31.4%, 29.3%) 112.5 0.966 (0.948, 0.978)
VII P01 P02 11.8 4.4% (-17.4%, 26.2%) 58.6 0.994 (0.992, 0.995)
P03 32.6 5.3% (-34.6%, 45.2%) 210.3 0.931 (0.908, 0.948)
P04 20.1 5.5% (-21.3%, 32.4%) 148.1 0.961 (0.951, 0.969)
P05 43.8 9% (-22%, 40%) 248.3 0.896 (0.866, 0.92)
P06 32.1 5.7% (-29.3%, 40.7%) 178.1 0.919 (0.893, 0.938)
P07 64.5 13.9% (-31.9%, 59.7%) 394.1 0.722 (0.641, 0.787)
P08 38.4 8.8% (-25.2%, 42.8%) 212.6 0.908 (0.889, 0.923)
P09 68.3 14.3% (-38.3%, 66.9%) 435.2 0.671 (0.572, 0.751)
P10 64.5 12% (-47.3%, 71.3%) 459.8 0.685 (0.578, 0.769)
P02 P03 18.1 1.3% (-36.3%, 38.9%) 172.1 0.952 (0.933, 0.965)
P04 7.3 0.6% (-24.6%, 25.9%) 120.8 0.973 (0.966, 0.979)
P05 33.1 5.3% (-29.5%, 40.2%) 216.9 0.914 (0.886, 0.936)
P06 19.0 0.9% (-31.9%, 33.8%) 130.5 0.953 (0.937, 0.965)
P07 54.2 10.4% (-37.9%, 58.7%) 358.2 0.746 (0.666, 0.808)
P08 26.7 4.1% (-24.9%, 33%) 176.4 0.933 (0.919, 0.945)
P09 55.7 11.2% (-37.9%, 60.3%) 391.7 0.708 (0.612, 0.783)
P10 48.6 8.7% (-47.6%, 65%) 414.6 0.717 (0.612, 0.797)
P03 P04 -3.6 1.2% (-29.3%, 31.8%) 80.5 0.989 (0.983, 0.992)
P05 13.0 4% (-24.9%, 32.9%) 142.3 0.96 (0.941, 0.973)
P06 13.4 1% (-28.2%, 30.2%) 107.4 0.969 (0.957, 0.978)
P07 36.2 9% (-41.8%, 59.8%) 247.3 0.855 (0.8, 0.897)
P08 17.9 4.5% (-28.3%, 37.3%) 122.6 0.967 (0.954, 0.977)
P09 41.8 10.2% (-40.5%, 61%) 256.3 0.848 (0.789, 0.892)
P10 28.0 6.7% (-54.2%, 67.7%) 276.5 0.85 (0.781, 0.899)
P04 P05 17.2 3.1% (-28.1%, 34.3%) 147.7 0.958 (0.939, 0.97)
P06 12.9 -0.9% (-29.1%, 27.4%) 100.2 0.973 (0.964, 0.98)
P07 39.8 8.2% (-35.6%, 51.9%) 250.2 0.856 (0.804, 0.895)
P08 17.5 3.3% (-22.1%, 28.8%) 113.5 0.969 (0.962, 0.976)
P09 45.3 9% (-39%, 57%) 277.4 0.831 (0.769, 0.877)
P10 31.7 5.8% (-48.2%, 59.8%) 281.2 0.851 (0.785, 0.897)
P05 P06 6.1 -1.8% (-24.1%, 20.5%) 85.0 0.981 (0.972, 0.986)
P07 23.9 6.4% (-28.2%, 41%) 168.1 0.927 (0.897, 0.949)
P08 5.7 1.5% (-26.8%, 29.7%) 95.4 0.98 (0.97, 0.986)
P09 27.5 6.6% (-38.4%, 51.5%) 222.5 0.878 (0.824, 0.916)
P10 20.4 4.4% (-42%, 50.9%) 223.8 0.897 (0.846, 0.932)
P06 P07 7.8 6.2% (-22.7%, 35.1%) 71.6 0.984 (0.976, 0.989)
P08 -0.6 2.7% (-21.6%, 27%) 72.7 0.985 (0.978, 0.99)
P09 7.6 7.5% (-28.9%, 43.9%) 76.7 0.983 (0.973, 0.989)
P10 -2.6 4.7% (-39.4%, 48.9%) 81.3 0.984 (0.975, 0.99)
P07 P08 -18.3 -4.9% (-45%, 35.2%) 167.7 0.925 (0.892, 0.949)
P09 4.0 1.3% (-39.6%, 42.2%) 135.5 0.949 (0.922, 0.966)
P10 -5.5 -0.9% (-41.7%, 39.9%) 110.2 0.971 (0.956, 0.981)
P08 P09 21.9 5.8% (-35.4%, 47%) 198.0 0.898 (0.85, 0.931)
P10 9.6 2.6% (-45.8%, 50.9%) 214.5 0.9 (0.849, 0.935)
P09 P10 -12.5 -2.7% (-29.7%, 24.3%) 95.9 0.974 (0.962, 0.982)
VIII P01 P02 11.4 4.9% (-15.5%, 25.4%) 63.1 0.993 (0.991, 0.995)
P03 27.6 4.9% (-27.2%, 37%) 263.3 0.894 (0.852, 0.924)
P04 16.6 4.5% (-23.9%, 32.9%) 181.3 0.943 (0.927, 0.956)
P05 52.1 12.1% (-28.6%, 52.8%) 347.8 0.79 (0.72, 0.845)
P06 26.9 8.4% (-20.5%, 37.4%) 121.5 0.962 (0.948, 0.972)
P07 63.3 15.1% (-28.1%, 58.2%) 352.8 0.761 (0.695, 0.815)
P08 37.2 10.3% (-22.6%, 43.3%) 263.8 0.869 (0.835, 0.896)
P09 56.0 12.2% (-36.3%, 60.8%) 416.9 0.712 (0.613, 0.79)
P10 63.6 15.4% (-40.8%, 71.7%) 425.5 0.717 (0.618, 0.793)
P02 P03 15.2 -0.4% (-36.7%, 35.9%) 233.3 0.916 (0.881, 0.941)
P04 5.0 -0.8% (-26.4%, 24.8%) 152.4 0.959 (0.947, 0.968)
P05 41.0 7.2% (-35.7%, 50.2%) 309.7 0.829 (0.768, 0.875)
P06 17.3 2.2% (-29.8%, 34.3%) 117.8 0.966 (0.953, 0.976)
P07 53.1 9.3% (-34.6%, 53.2%) 327.4 0.786 (0.724, 0.836)
P08 27.7 5.8% (-30.1%, 41.8%) 241.6 0.885 (0.855, 0.91)
P09 45.2 6.3% (-45.1%, 57.7%) 385.5 0.744 (0.651, 0.815)
P10 50.0 9.2% (-45.9%, 64.3%) 392.5 0.745 (0.652, 0.816)
P03 P04 -4.8 0% (-24.1%, 24.1%) 77.8 0.99 (0.985, 0.993)
P05 25.9 7.9% (-19.7%, 35.4%) 116.7 0.968 (0.956, 0.977)
P06 23.2 5.6% (-30.1%, 41.3%) 151.7 0.943 (0.918, 0.96)
P07 40.8 10.3% (-24.9%, 45.4%) 207.2 0.891 (0.854, 0.919)
P08 26.5 8.7% (-25.6%, 43%) 163.3 0.943 (0.918, 0.961)
P09 28.5 7.4% (-30.5%, 45.4%) 202.0 0.914 (0.875, 0.941)
P10 33.3 9.7% (-34.7%, 54.1%) 178.6 0.932 (0.902, 0.952)
P04 P05 30.6 8.4% (-21.1%, 37.9%) 138.7 0.957 (0.941, 0.968)
P06 25.4 5% (-28.2%, 38.2%) 149.2 0.945 (0.923, 0.961)
P07 45.2 10.2% (-24.3%, 44.6%) 227.8 0.874 (0.833, 0.905)
P08 23.0 7% (-21.4%, 35.4%) 126.9 0.962 (0.951, 0.971)
P09 30.9 6.1% (-35.7%, 47.9%) 222.2 0.899 (0.856, 0.93)
P10 37.5 9.5% (-34.2%, 53.3%) 219.2 0.903 (0.864, 0.932)
P05 P06 3.5 -1.5% (-34.2%, 31.3%) 133.8 0.954 (0.93, 0.969)
P07 15.5 2.2% (-35.5%, 39.9%) 173.9 0.918 (0.883, 0.943)
P08 1.4 0.4% (-28.3%, 29.1%) 118.7 0.969 (0.953, 0.979)
P09 2.2 -0.4% (-40%, 39.3%) 159.9 0.942 (0.912, 0.962)
P10 6.8 0.5% (-30.5%, 31.5%) 111.2 0.973 (0.958, 0.982)
P06 P07 12.2 4.4% (-30.4%, 39.1%) 155.5 0.924 (0.89, 0.948)
P08 -8.1 0.7% (-34.6%, 36.1%) 138.1 0.953 (0.93, 0.968)
P09 -11.0 -0.9% (-38.4%, 36.6%) 148.2 0.945 (0.916, 0.964)
P10 -1.9 1.6% (-42%, 45.1%) 152.1 0.945 (0.915, 0.965)
P07 P08 -14.3 -1.9% (-41.5%, 37.7%) 197.9 0.898 (0.856, 0.929)
P09 -7.7 -1.7% (-36.3%, 32.9%) 145.3 0.946 (0.919, 0.964)
P10 -8.9 -0.7% (-44.1%, 42.8%) 138.9 0.951 (0.925, 0.968)
P08 P09 -1.3 -1.6% (-38.8%, 35.6%) 136.9 0.958 (0.936, 0.972)
P10 9.7 1.7% (-31.4%, 34.8%) 134.8 0.961 (0.942, 0.974)
P09 P10 3.5 3% (-43.5%, 49.5%) 134.5 0.957 (0.934, 0.972)

3.0T

Table 10: Between-protocol reproducibility analysis of R2* by segment in 3.0T.
Segment Protocol x Protocol y Bias Bias (%) (LoA %) CR CCC (95% CI)
I P01 P02 29.2 6.1% (-24.1%, 36.3%) 322.2 0.929 (0.906, 0.946)
P03 116.7 14.7% (-66.7%, 96%) 702.6 0.556 (0.435, 0.657)
P04 117.7 13.8% (-67%, 94.6%) 702.7 0.526 (0.441, 0.602)
P05 157.3 21.2% (-59.5%, 101.9%) 741.5 0.419 (0.299, 0.526)
P06 176.1 26.7% (-62.5%, 115.9%) 770.6 0.351 (0.231, 0.461)
P07 153.3 23.9% (-57.6%, 105.5%) 706.4 0.436 (0.315, 0.543)
P08 146.2 21.3% (-54.9%, 97.5%) 734.4 0.43 (0.35, 0.504)
P09 51.3 2.4% (-76.3%, 81.1%) 569.9 0.644 (0.502, 0.753)
P10 173.6 21.7% (-70.4%, 113.9%) 810.3 0.411 (0.271, 0.533)
P02 P03 65.5 6% (-71.1%, 83.2%) 700.4 0.53 (0.39, 0.646)
P04 73.4 6% (-66.7%, 78.7%) 640.8 0.563 (0.474, 0.64)
P05 111.0 12.5% (-60.9%, 85.9%) 726.1 0.437 (0.31, 0.549)
P06 140.0 19.8% (-67.5%, 107%) 787.0 0.325 (0.194, 0.445)
P07 112.4 15.2% (-59.6%, 90.1%) 751.9 0.382 (0.244, 0.505)
P08 108.5 14.5% (-60.4%, 89.4%) 687.7 0.441 (0.354, 0.521)
P09 -12.9 -6.7% (-73.2%, 59.9%) 391.0 0.77 (0.655, 0.851)
P10 110.1 12.5% (-70.1%, 95.1%) 711.5 0.467 (0.316, 0.595)
P03 P04 20.8 2.4% (-73.9%, 78.6%) 283.4 0.854 (0.787, 0.901)
P05 41.8 5.7% (-47.2%, 58.5%) 211.4 0.896 (0.855, 0.925)
P06 68.7 14.1% (-63.4%, 91.6%) 295.9 0.783 (0.705, 0.843)
P07 53.5 11.1% (-57.8%, 80.1%) 252.6 0.85 (0.79, 0.893)
P08 34.4 7.8% (-48.7%, 64.2%) 219.2 0.892 (0.845, 0.925)
P09 -4.4 -5.7% (-76.9%, 65.5%) 300.5 0.857 (0.78, 0.909)
P10 40.1 5.5% (-62%, 73%) 218.8 0.905 (0.858, 0.937)
P04 P05 21.8 2.9% (-64.1%, 69.8%) 209.3 0.898 (0.854, 0.93)
P06 52.3 12.8% (-49.9%, 75.5%) 251.0 0.831 (0.764, 0.881)
P07 33.1 8.8% (-65.4%, 83%) 228.1 0.875 (0.821, 0.914)
P08 31.9 8% (-43%, 59.1%) 237.5 0.863 (0.824, 0.893)
P09 -21.3 -5.3% (-72.5%, 62%) 295.7 0.849 (0.77, 0.902)
P10 11.8 2.3% (-72.1%, 76.6%) 269.6 0.853 (0.777, 0.905)
P05 P06 26.6 8.2% (-61%, 77.4%) 210.3 0.866 (0.804, 0.91)
P07 10.8 5.3% (-46.5%, 57.2%) 154.2 0.934 (0.9, 0.956)
P08 -2.1 3.3% (-45.1%, 51.6%) 136.8 0.951 (0.926, 0.968)
P09 -51.9 -12.6% (-71.8%, 46.6%) 301.7 0.808 (0.721, 0.87)
P10 -10.4 -1.8% (-52.8%, 49.2%) 184.0 0.921 (0.877, 0.949)
P06 P07 -14.8 -2.6% (-76.8%, 71.5%) 182.7 0.901 (0.852, 0.934)
P08 -30.0 -5.2% (-76.9%, 66.4%) 191.3 0.89 (0.838, 0.926)
P09 -77.9 -19.6% (-90.4%, 51.2%) 320.2 0.755 (0.657, 0.828)
P10 -35.5 -9.2% (-82.7%, 64.3%) 259.5 0.826 (0.74, 0.885)
P07 P08 -15.7 -3.2% (-57.6%, 51.1%) 137.7 0.948 (0.921, 0.966)
P09 -62.1 -17% (-71.3%, 37.3%) 268.9 0.833 (0.76, 0.884)
P10 -28.3 -9.2% (-75.6%, 57.2%) 197.4 0.902 (0.85, 0.937)
P08 P09 -48.6 -16.9% (-70%, 36.3%) 259.3 0.858 (0.792, 0.905)
P10 -1.4 -5% (-68.9%, 58.9%) 126.4 0.962 (0.939, 0.976)
P09 P10 41.7 9.3% (-47.3%, 65.8%) 275.1 0.846 (0.772, 0.898)
II P01 P02 61.3 7.8% (-22.3%, 37.9%) 331.3 0.917 (0.899, 0.932)
P03 136.8 14.5% (-61.7%, 90.8%) 739.3 0.551 (0.43, 0.652)
P04 138.7 16.9% (-55.7%, 89.6%) 731.9 0.502 (0.424, 0.572)
P05 186.3 22.4% (-73.9%, 118.8%) 867.3 0.35 (0.225, 0.463)
P06 207.5 27.2% (-70.1%, 124.5%) 911.6 0.285 (0.161, 0.401)
P07 185.4 23.8% (-67.3%, 114.8%) 786.3 0.381 (0.262, 0.489)
P08 171.2 21.8% (-57.3%, 100.9%) 817.2 0.372 (0.29, 0.448)
P09 32.2 0.7% (-72.7%, 74.1%) 498.9 0.73 (0.612, 0.816)
P10 209.3 23.5% (-81.9%, 128.9%) 985.7 0.279 (0.137, 0.409)
P02 P03 76.1 8.8% (-59%, 76.5%) 500.1 0.682 (0.571, 0.768)
P04 69.7 8.7% (-52.2%, 69.5%) 467.5 0.692 (0.623, 0.75)
P05 105.5 14.3% (-65.6%, 94.3%) 549.6 0.575 (0.452, 0.678)
P06 131.8 20.9% (-67.1%, 109%) 619.6 0.453 (0.312, 0.574)
P07 117.2 16.5% (-64.6%, 97.7%) 549.8 0.545 (0.421, 0.649)
P08 107.3 15% (-59.7%, 89.7%) 563.1 0.529 (0.443, 0.605)
P09 -7.2 -4.3% (-67.7%, 59%) 366.4 0.82 (0.727, 0.884)
P10 116.3 16.4% (-77.9%, 110.6%) 606.7 0.517 (0.365, 0.642)
P03 P04 12.7 3.3% (-48.7%, 55.4%) 338.8 0.81 (0.726, 0.87)
P05 43.4 8.2% (-54%, 70.3%) 345.5 0.771 (0.678, 0.84)
P06 71.5 16.1% (-53.3%, 85.6%) 391.5 0.69 (0.576, 0.778)
P07 63.1 12.4% (-56%, 80.8%) 405.4 0.664 (0.544, 0.758)
P08 42.7 9.8% (-38.9%, 58.5%) 272.5 0.856 (0.795, 0.899)
P09 -32.2 -6.6% (-73.6%, 60.4%) 397.9 0.753 (0.631, 0.838)
P10 39.7 8.4% (-72.5%, 89.3%) 458.4 0.642 (0.493, 0.755)
P04 P05 36.2 7.9% (-47.6%, 63.4%) 189.4 0.917 (0.879, 0.943)
P06 56.7 12.9% (-45.8%, 71.6%) 235.5 0.861 (0.802, 0.903)
P07 49.0 8.7% (-46.7%, 64.2%) 254.9 0.842 (0.776, 0.89)
P08 27.4 5.7% (-39.9%, 51.3%) 158.6 0.929 (0.908, 0.946)
P09 -54.6 -12.8% (-67.6%, 41.9%) 256.4 0.865 (0.802, 0.909)
P10 25.6 5.9% (-61.2%, 73.1%) 262.9 0.864 (0.794, 0.911)
P05 P06 24.0 7.1% (-59.1%, 73.3%) 233.5 0.863 (0.798, 0.908)
P07 15.5 2.1% (-61.7%, 65.9%) 257.6 0.831 (0.754, 0.886)
P08 0.1 1.2% (-62.5%, 64.9%) 211.4 0.898 (0.847, 0.932)
P09 -80.4 -17.2% (-87.2%, 52.7%) 313.1 0.771 (0.679, 0.839)
P10 -4.7 -0.7% (-66.9%, 65.6%) 285.0 0.826 (0.736, 0.888)
P06 P07 -7.4 -3.7% (-60.7%, 53.2%) 223.2 0.87 (0.806, 0.913)
P08 -24.4 -6.3% (-65.3%, 52.8%) 187.9 0.911 (0.867, 0.941)
P09 -105.1 -23.7% (-88.9%, 41.4%) 307.6 0.736 (0.642, 0.808)
P10 -38.8 -8.9% (-77.4%, 59.5%) 257.7 0.83 (0.744, 0.889)
P07 P08 -20.1 -3.7% (-61.1%, 53.6%) 248.5 0.846 (0.774, 0.896)
P09 -92.1 -19.2% (-85.3%, 47%) 293.7 0.787 (0.701, 0.85)
P10 -34.0 -6.1% (-65.5%, 53.3%) 243.3 0.852 (0.774, 0.904)
P08 P09 -80.2 -17.3% (-77.5%, 43%) 284.5 0.805 (0.728, 0.862)
P10 -10.8 -1.6% (-75.3%, 72.1%) 270.0 0.836 (0.751, 0.894)
P09 P10 57.5 11.9% (-53.5%, 77.3%) 275.1 0.851 (0.778, 0.901)
III P01 P02 22.3 5.6% (-22.9%, 34%) 272.1 0.96 (0.946, 0.969)
P03 179.8 18.5% (-63.4%, 100.3%) 895.0 0.434 (0.315, 0.539)
P04 113.4 12% (-54.3%, 78.2%) 705.5 0.614 (0.537, 0.681)
P05 200.5 23.7% (-64.1%, 111.6%) 935.0 0.381 (0.256, 0.493)
P06 207.6 22.8% (-63.9%, 109.5%) 969.4 0.318 (0.2, 0.427)
P07 196.0 23.1% (-59.8%, 106%) 897.5 0.394 (0.281, 0.497)
P08 156.2 19.6% (-52.7%, 91.8%) 782.7 0.462 (0.383, 0.535)
P09 97.8 8.1% (-67.4%, 83.7%) 673.5 0.541 (0.401, 0.656)
P10 207.5 21.2% (-74.9%, 117.2%) 960.9 0.378 (0.239, 0.502)
P02 P03 120.8 11.2% (-59.2%, 81.6%) 730.8 0.547 (0.43, 0.646)
P04 78.2 5.3% (-55.5%, 66.1%) 596.3 0.7 (0.633, 0.757)
P05 131.1 16.2% (-61.3%, 93.8%) 701.8 0.534 (0.41, 0.639)
P06 146.6 16.6% (-63.7%, 96.8%) 775.3 0.41 (0.28, 0.525)
P07 124.2 14.7% (-55.9%, 85.4%) 699.9 0.506 (0.384, 0.61)
P08 132.0 13.9% (-61.2%, 89%) 752.9 0.477 (0.395, 0.551)
P09 49.8 2% (-65.8%, 69.8%) 515.5 0.672 (0.547, 0.767)
P10 145.8 13.6% (-72.6%, 99.7%) 822.2 0.461 (0.317, 0.585)
P03 P04 -17.9 -4.2% (-35.8%, 27.4%) 150.4 0.959 (0.939, 0.973)
P05 19.5 6.5% (-43%, 56.1%) 286.7 0.851 (0.782, 0.9)
P06 34.6 7.5% (-49.4%, 64.4%) 287.2 0.828 (0.753, 0.882)
P07 24.3 5.9% (-40.1%, 51.9%) 276.8 0.845 (0.775, 0.895)
P08 14.6 4.6% (-38.7%, 47.8%) 244.5 0.884 (0.83, 0.922)
P09 -2.3 -3.4% (-60.8%, 54.1%) 244.0 0.889 (0.828, 0.929)
P10 5.1 1.9% (-65.6%, 69.5%) 251.1 0.893 (0.834, 0.932)
P04 P05 34.4 9.7% (-40.4%, 59.8%) 285.9 0.85 (0.781, 0.899)
P06 46.3 9.6% (-41.4%, 60.6%) 280.1 0.834 (0.763, 0.885)
P07 42.1 10.2% (-29.8%, 50.1%) 249.4 0.87 (0.813, 0.911)
P08 42.9 8% (-33.2%, 49.2%) 298.4 0.84 (0.798, 0.874)
P09 14.8 0.3% (-54.9%, 55.5%) 240.7 0.893 (0.836, 0.931)
P10 20.5 6.2% (-59.5%, 72%) 258.8 0.884 (0.822, 0.926)
P05 P06 13.4 0.4% (-61%, 61.8%) 279.8 0.839 (0.767, 0.89)
P07 4.5 -0.5% (-58.3%, 57.3%) 335.4 0.774 (0.676, 0.845)
P08 -2.4 -0.9% (-49.1%, 47.2%) 257.8 0.871 (0.81, 0.913)
P09 -14.1 -7.3% (-79.5%, 64.9%) 374.8 0.739 (0.612, 0.83)
P10 -9.2 -4.3% (-81.1%, 72.6%) 402.5 0.733 (0.604, 0.824)
P06 P07 -8.4 -1.3% (-59%, 56.3%) 263.5 0.84 (0.765, 0.893)
P08 -13.8 -1.6% (-50.6%, 47.3%) 167.3 0.935 (0.902, 0.957)
P09 -32.7 -7.8% (-64.2%, 48.7%) 233.4 0.866 (0.797, 0.912)
P10 -20.9 -2.5% (-78.8%, 73.8%) 347.8 0.766 (0.653, 0.846)
P07 P08 -18.9 -2.5% (-44.8%, 39.7%) 179.2 0.923 (0.886, 0.948)
P09 -31.0 -9% (-64.7%, 46.6%) 219.7 0.885 (0.825, 0.926)
P10 -20.4 -3.2% (-69.9%, 63.5%) 308.2 0.822 (0.731, 0.884)
P08 P09 -10.7 -6.2% (-64.4%, 52%) 211.2 0.908 (0.856, 0.942)
P10 -4.2 -2.4% (-76.7%, 71.9%) 310.8 0.825 (0.735, 0.886)
P09 P10 0.6 3.6% (-61.7%, 68.8%) 229.3 0.905 (0.851, 0.94)
IVA P01 P02 34.7 7.2% (-21.2%, 35.5%) 253.0 0.965 (0.955, 0.974)
P03 112.6 12.2% (-54.2%, 78.7%) 739.9 0.647 (0.538, 0.735)
P04 91.6 10.4% (-52.4%, 73.3%) 663.0 0.703 (0.635, 0.761)
P05 168.2 21.1% (-57.1%, 99.3%) 853.8 0.48 (0.358, 0.585)
P06 165.8 19.8% (-60.3%, 99.8%) 861.1 0.483 (0.357, 0.592)
P07 171.3 23.8% (-55.3%, 102.9%) 842.5 0.474 (0.347, 0.584)
P08 141.3 17.4% (-50.2%, 84.9%) 753.4 0.561 (0.487, 0.628)
P09 53.3 4.9% (-67.6%, 77.3%) 507.1 0.752 (0.644, 0.831)
P10 181.5 22.2% (-74.1%, 118.6%) 948.0 0.427 (0.274, 0.559)
P02 P03 51.5 2.6% (-50.7%, 56%) 557.7 0.767 (0.679, 0.833)
P04 48.3 2.4% (-48.7%, 53.5%) 547.2 0.781 (0.724, 0.827)
P05 114.0 12% (-55.8%, 79.8%) 685.7 0.602 (0.489, 0.696)
P06 119.7 12.1% (-60.6%, 84.8%) 711.2 0.582 (0.461, 0.682)
P07 117.1 14.3% (-50.8%, 79.4%) 678.0 0.601 (0.483, 0.697)
P08 100.4 9.8% (-52%, 71.6%) 638.7 0.641 (0.571, 0.701)
P09 12.7 -4% (-66.1%, 58.1%) 363.5 0.86 (0.788, 0.908)
P10 110.8 13.1% (-78.5%, 104.7%) 720.4 0.585 (0.441, 0.7)
P03 P04 13.4 3.4% (-36.5%, 43.4%) 187.7 0.962 (0.943, 0.975)
P05 52.3 9.6% (-29.7%, 49%) 242.8 0.914 (0.879, 0.94)
P06 55.6 9.7% (-39.7%, 59%) 278.4 0.895 (0.849, 0.927)
P07 70.5 14.9% (-37.9%, 67.6%) 319.4 0.854 (0.792, 0.898)
P08 42.4 8% (-20.6%, 36.5%) 139.9 0.968 (0.955, 0.977)
P09 26.4 -0.2% (-65.6%, 65.2%) 335.3 0.873 (0.806, 0.918)
P10 50.3 11.6% (-59.3%, 82.5%) 237.9 0.929 (0.892, 0.953)
P04 P05 41.2 7.1% (-29.1%, 43.2%) 190.1 0.946 (0.926, 0.961)
P06 43.4 6.8% (-39.6%, 53.2%) 231.9 0.927 (0.895, 0.949)
P07 58.5 11.9% (-30.8%, 54.7%) 254.1 0.905 (0.865, 0.933)
P08 46.6 6.7% (-37.8%, 51.1%) 290.6 0.886 (0.856, 0.91)
P09 9.3 -3.7% (-68.7%, 61.2%) 310.5 0.889 (0.83, 0.928)
P10 33.9 7.3% (-66.1%, 80.7%) 303.4 0.895 (0.842, 0.931)
P05 P06 4.1 0.5% (-40.1%, 41.2%) 159.3 0.962 (0.942, 0.975)
P07 16.4 5% (-33.3%, 43.3%) 150.5 0.963 (0.944, 0.976)
P08 -4.6 -1% (-30.2%, 28.2%) 155.1 0.964 (0.946, 0.976)
P09 -24.2 -9.1% (-68.8%, 50.6%) 238.5 0.92 (0.875, 0.949)
P10 -5.4 -0.3% (-55.8%, 55.1%) 232.3 0.928 (0.887, 0.954)
P06 P07 12.9 4.4% (-35.4%, 44.1%) 189.0 0.946 (0.918, 0.965)
P08 -8.1 -1.2% (-41.1%, 38.7%) 208.8 0.937 (0.905, 0.959)
P09 -26.8 -8% (-71.3%, 55.4%) 321.3 0.859 (0.783, 0.91)
P10 -10.7 0.1% (-56.3%, 56.5%) 257.5 0.914 (0.865, 0.946)
P07 P08 -19.8 -5.5% (-47.2%, 36.3%) 229.0 0.921 (0.882, 0.948)
P09 -41.3 -13% (-73.6%, 47.5%) 238.0 0.913 (0.866, 0.944)
P10 -25.8 -5.2% (-64.4%, 54%) 286.2 0.889 (0.828, 0.929)
P08 P09 -14.9 -7.3% (-64%, 49.3%) 278.3 0.9 (0.843, 0.936)
P10 3.0 4.5% (-64.3%, 73.3%) 161.6 0.966 (0.947, 0.979)
P09 P10 4.2 4.7% (-55.3%, 64.7%) 302.3 0.886 (0.822, 0.929)
IVB P01 P02 18.1 5.3% (-16%, 26.5%) 198.8 0.978 (0.971, 0.984)
P03 113.4 11.5% (-54.8%, 77.8%) 702.3 0.668 (0.563, 0.752)
P04 93.3 9.5% (-45.7%, 64.7%) 583.2 0.735 (0.677, 0.784)
P05 164.8 21.3% (-52.7%, 95.2%) 785.2 0.522 (0.405, 0.622)
P06 164.8 21.1% (-51%, 93.1%) 741.5 0.558 (0.453, 0.648)
P07 166.4 22% (-44.3%, 88.4%) 753.6 0.542 (0.434, 0.634)
P08 144.0 17.8% (-51.8%, 87.4%) 743.2 0.522 (0.444, 0.592)
P09 76.8 7.2% (-67.1%, 81.6%) 589.2 0.641 (0.512, 0.742)
P10 169.0 20.7% (-69.4%, 110.7%) 869.0 0.472 (0.323, 0.599)
P02 P03 81.9 4.3% (-60.7%, 69.4%) 715.2 0.636 (0.518, 0.73)
P04 65.5 3.4% (-50.4%, 57.2%) 550.6 0.752 (0.693, 0.8)
P05 123.6 12.9% (-57.4%, 83.3%) 739.1 0.553 (0.432, 0.655)
P06 140.3 15% (-59.4%, 89.5%) 739.9 0.533 (0.418, 0.631)
P07 119.0 13.6% (-46.3%, 73.4%) 671.1 0.602 (0.494, 0.691)
P08 122.7 12.4% (-59.6%, 84.5%) 731.0 0.502 (0.419, 0.576)
P09 30.5 -0.9% (-69.9%, 68.1%) 414.7 0.786 (0.69, 0.855)
P10 137.6 13.9% (-77.3%, 105%) 875.4 0.452 (0.29, 0.588)
P03 P04 7.3 1.6% (-38.2%, 41.4%) 324.3 0.883 (0.828, 0.921)
P05 54.8 10.7% (-27.8%, 49.3%) 258.4 0.903 (0.864, 0.932)
P06 64.3 11.7% (-41.3%, 64.6%) 338.7 0.837 (0.772, 0.885)
P07 63.9 12.1% (-29.7%, 53.9%) 325.4 0.844 (0.784, 0.889)
P08 40.9 9.1% (-29.1%, 47.3%) 208.4 0.94 (0.915, 0.958)
P09 40.2 3.1% (-67.9%, 74.2%) 434.0 0.752 (0.639, 0.833)
P10 53.6 11.7% (-62.7%, 86%) 455.4 0.763 (0.652, 0.842)
P04 P05 46.9 9.3% (-33.9%, 52.5%) 305.8 0.863 (0.803, 0.906)
P06 54.9 9.8% (-40.3%, 59.8%) 297.3 0.864 (0.805, 0.905)
P07 54.9 10.4% (-24.3%, 45.2%) 244.1 0.901 (0.86, 0.931)
P08 45.8 8.5% (-32.8%, 49.8%) 311.3 0.842 (0.798, 0.877)
P09 22.1 0% (-63.6%, 63.7%) 290.9 0.874 (0.809, 0.918)
P10 37.6 8.7% (-62.5%, 79.9%) 365.1 0.834 (0.75, 0.892)
P05 P06 9.5 1.4% (-47.6%, 50.5%) 282.2 0.869 (0.807, 0.912)
P07 8.4 1.4% (-32.1%, 34.9%) 153.6 0.96 (0.941, 0.974)
P08 -12.6 -1.1% (-39.9%, 37.7%) 218.6 0.927 (0.89, 0.951)
P09 -7.2 -5.7% (-72.9%, 61.5%) 319.4 0.839 (0.754, 0.897)
P10 -11.2 -0.7% (-61.1%, 59.7%) 339.2 0.838 (0.754, 0.896)
P06 P07 -1.0 0.2% (-47.4%, 47.7%) 245.8 0.896 (0.845, 0.931)
P08 -23.5 -2.4% (-53.7%, 48.8%) 230.7 0.913 (0.87, 0.942)
P09 -20.2 -8.1% (-74.1%, 57.8%) 338.6 0.81 (0.71, 0.878)
P10 -19.0 -2.2% (-67.9%, 63.4%) 299.3 0.87 (0.801, 0.916)
P07 P08 -24.0 -3.1% (-45%, 38.9%) 235.0 0.908 (0.864, 0.938)
P09 -18.0 -7.8% (-67.5%, 52%) 254.9 0.889 (0.827, 0.93)
P10 -23.1 -3.5% (-56.1%, 49.2%) 282.9 0.88 (0.817, 0.923)
P08 P09 4.4 -5% (-79.5%, 69.5%) 346.8 0.813 (0.717, 0.879)
P10 1.8 1.3% (-71.4%, 74%) 333.8 0.85 (0.77, 0.903)
P09 P10 -13.1 1.3% (-56.8%, 59.4%) 263.2 0.899 (0.844, 0.935)
V P01 P02 27.8 4.9% (-9.5%, 19.2%) 163.2 0.986 (0.983, 0.989)
P03 120.8 11.4% (-50.1%, 72.9%) 776.0 0.636 (0.527, 0.724)
P04 76.8 6.9% (-44.6%, 58.3%) 611.7 0.775 (0.72, 0.82)
P05 155.6 21% (-45.7%, 87.6%) 836.4 0.568 (0.454, 0.664)
P06 160.9 17.9% (-49.2%, 85.1%) 866.2 0.527 (0.411, 0.626)
P07 133.5 16.3% (-45%, 77.7%) 741.7 0.624 (0.515, 0.714)
P08 135.3 15.4% (-42.6%, 73.5%) 783.0 0.58 (0.505, 0.647)
P09 27.2 1.9% (-42.3%, 46%) 283.4 0.923 (0.885, 0.948)
P10 169.1 16.5% (-72.5%, 105.6%) 1043.4 0.43 (0.27, 0.567)
P02 P03 87.1 5.6% (-51.2%, 62.4%) 697.5 0.662 (0.556, 0.748)
P04 41.8 1.2% (-43.5%, 45.8%) 509.8 0.826 (0.778, 0.864)
P05 99.0 13.6% (-41.2%, 68.4%) 636.0 0.695 (0.595, 0.774)
P06 111.9 11.8% (-50.8%, 74.3%) 678.5 0.641 (0.533, 0.728)
P07 85.2 9.2% (-42.3%, 60.7%) 612.8 0.709 (0.609, 0.787)
P08 106.3 10.9% (-45.7%, 67.5%) 682.4 0.635 (0.562, 0.698)
P09 2.4 -3.3% (-46.3%, 39.7%) 239.8 0.939 (0.905, 0.961)
P10 120.3 10.6% (-76.2%, 97.4%) 903.0 0.501 (0.338, 0.636)
P03 P04 -14.7 -2% (-30.1%, 26.1%) 193.0 0.962 (0.944, 0.975)
P05 29.1 9.7% (-23.7%, 43%) 231.2 0.939 (0.909, 0.959)
P06 42.2 7.5% (-29.8%, 44.9%) 280.2 0.903 (0.86, 0.934)
P07 29.5 6.5% (-24.2%, 37.3%) 267.8 0.919 (0.879, 0.945)
P08 33.3 6.6% (-17.5%, 30.7%) 214.5 0.938 (0.911, 0.957)
P09 1.5 -2% (-46.2%, 42.3%) 261.0 0.929 (0.889, 0.955)
P10 26.8 6.6% (-57.1%, 70.3%) 348.3 0.881 (0.818, 0.924)
P04 P05 46.5 12.7% (-17.5%, 43%) 186.1 0.955 (0.935, 0.969)
P06 57.6 10.3% (-27.7%, 48.4%) 241.0 0.923 (0.891, 0.946)
P07 43.6 8.7% (-20.3%, 37.6%) 218.6 0.943 (0.917, 0.961)
P08 54.8 9.1% (-25.5%, 43.7%) 296.7 0.896 (0.868, 0.918)
P09 9.2 -0.9% (-43.4%, 41.6%) 212.2 0.953 (0.926, 0.97)
P10 32.5 7.3% (-50.7%, 65.4%) 284.4 0.919 (0.875, 0.948)
P05 P06 12.3 -1.6% (-38%, 34.7%) 153.1 0.97 (0.955, 0.98)
P07 0.0 -3.1% (-31.6%, 25.4%) 155.3 0.972 (0.957, 0.981)
P08 4.8 -2.1% (-34.3%, 30.1%) 225.0 0.931 (0.897, 0.954)
P09 -31.9 -11.4% (-61.1%, 38.3%) 287.8 0.901 (0.846, 0.938)
P10 -2.9 -1.4% (-64.7%, 62%) 246.6 0.938 (0.902, 0.961)
P06 P07 -14.4 -1.8% (-29.7%, 26.1%) 158.0 0.968 (0.952, 0.979)
P08 -7.2 -0.8% (-37.8%, 36.2%) 206.9 0.938 (0.906, 0.959)
P09 -44.5 -10.5% (-62.6%, 41.5%) 274.8 0.901 (0.846, 0.937)
P10 -23.2 -1.2% (-66.2%, 63.8%) 254.8 0.927 (0.888, 0.952)
P07 P08 -0.5 0.1% (-25.9%, 26.1%) 166.3 0.96 (0.939, 0.974)
P09 -32.2 -8.1% (-50.5%, 34.3%) 224.4 0.935 (0.898, 0.958)
P10 -8.0 0.2% (-56.2%, 56.7%) 226.9 0.947 (0.917, 0.967)
P08 P09 -30.7 -8.6% (-47.2%, 30%) 160.6 0.965 (0.945, 0.977)
P10 -0.5 2.2% (-62.8%, 67.2%) 300.8 0.887 (0.827, 0.928)
P09 P10 23.7 5.3% (-42.9%, 53.4%) 259.4 0.919 (0.872, 0.949)
VI P01 P02 30.7 6.2% (-9.3%, 21.7%) 168.8 0.986 (0.982, 0.989)
P03 82.5 7.2% (-43.6%, 58%) 614.1 0.793 (0.718, 0.85)
P04 78.8 7% (-41%, 55.1%) 604.2 0.794 (0.744, 0.834)
P05 148.0 16.9% (-46%, 79.8%) 816.2 0.609 (0.502, 0.697)
P06 160.9 18.1% (-55.9%, 92%) 878.8 0.544 (0.427, 0.643)
P07 131.5 17.1% (-36.9%, 71.2%) 646.5 0.711 (0.627, 0.779)
P08 127.6 15.1% (-37.5%, 67.8%) 720.8 0.67 (0.607, 0.725)
P09 48.6 6.9% (-41.7%, 55.4%) 373.1 0.872 (0.814, 0.914)
P10 183.0 19.7% (-67.7%, 107.1%) 1001.5 0.466 (0.318, 0.593)
P02 P03 45.5 0% (-48.9%, 48.9%) 582.0 0.798 (0.72, 0.857)
P04 41.1 0.1% (-44.1%, 44.2%) 541.4 0.82 (0.772, 0.858)
P05 98.0 9.4% (-49.9%, 68.6%) 670.7 0.674 (0.571, 0.756)
P06 116.9 11.7% (-63.4%, 86.7%) 730.7 0.607 (0.49, 0.703)
P07 80.6 8.7% (-36.7%, 54.1%) 538.7 0.776 (0.699, 0.835)
P08 97.1 9.2% (-43.8%, 62.2%) 662.9 0.688 (0.623, 0.743)
P09 6.8 -0.5% (-43.1%, 42.1%) 174.9 0.968 (0.951, 0.98)
P10 130.3 12.2% (-74.5%, 99%) 890.9 0.513 (0.356, 0.642)
P03 P04 16.9 3.1% (-28.5%, 34.6%) 229.3 0.953 (0.93, 0.968)
P05 57.5 9.7% (-27.9%, 47.4%) 319.4 0.899 (0.857, 0.93)
P06 79.0 12.7% (-45.1%, 70.5%) 369.4 0.858 (0.801, 0.9)
P07 66.7 11.4% (-27.5%, 50.4%) 327.7 0.889 (0.844, 0.922)
P08 57.0 11.4% (-26.3%, 49%) 293.0 0.91 (0.872, 0.937)
P09 31.5 5.6% (-40.9%, 52.2%) 274.8 0.92 (0.876, 0.949)
P10 87.4 14.9% (-64.4%, 94.1%) 540.4 0.747 (0.634, 0.828)
P04 P05 39.2 7.4% (-29.2%, 44.1%) 186.6 0.958 (0.938, 0.971)
P06 48.6 8.7% (-44.8%, 62.2%) 261.7 0.92 (0.883, 0.945)
P07 42.4 8% (-20.8%, 36.8%) 160.9 0.966 (0.951, 0.976)
P08 51.0 8.9% (-21.9%, 39.6%) 247.8 0.931 (0.912, 0.945)
P09 26.8 4% (-42.6%, 50.7%) 252.2 0.931 (0.893, 0.956)
P10 51.6 10.8% (-53.5%, 75.2%) 280.0 0.917 (0.873, 0.946)
P05 P06 18.9 2.7% (-61%, 66.4%) 326.2 0.878 (0.819, 0.918)
P07 8.8 1.7% (-30%, 33.3%) 204.9 0.953 (0.929, 0.969)
P08 1.9 1.8% (-32.3%, 35.8%) 113.0 0.985 (0.978, 0.991)
P09 -8.6 -2.6% (-54.1%, 48.9%) 319.6 0.883 (0.818, 0.926)
P10 17.7 3% (-67.1%, 73%) 417.2 0.823 (0.73, 0.885)
P06 P07 -12.2 -1.7% (-63.3%, 59.8%) 312.5 0.887 (0.831, 0.925)
P08 -13.6 -0.4% (-65.6%, 64.8%) 339.6 0.866 (0.801, 0.911)
P09 -22.5 -5.1% (-70.9%, 60.8%) 274.5 0.91 (0.859, 0.943)
P10 1.6 2.7% (-83.5%, 88.9%) 394.3 0.839 (0.753, 0.897)
P07 P08 -4.9 0.8% (-36.7%, 38.2%) 264.6 0.919 (0.878, 0.946)
P09 -16.7 -4.6% (-50%, 40.9%) 206.5 0.95 (0.92, 0.968)
P10 10.3 1.9% (-63%, 66.9%) 312.9 0.899 (0.843, 0.936)
P08 P09 -12.7 -5.6% (-58.4%, 47.2%) 356.2 0.854 (0.775, 0.906)
P10 27.8 4.3% (-77.4%, 86%) 460.1 0.761 (0.645, 0.843)
P09 P10 10.0 1.9% (-38.5%, 42.3%) 164.7 0.968 (0.949, 0.98)
VII P01 P02 27.8 5.1% (-17.3%, 27.5%) 210.2 0.977 (0.969, 0.982)
P03 81.1 5.5% (-60.8%, 71.7%) 637.2 0.746 (0.652, 0.817)
P04 65.0 5.8% (-49.6%, 61.2%) 533.9 0.819 (0.773, 0.856)
P05 149.6 13.5% (-64.8%, 91.7%) 849.4 0.521 (0.402, 0.622)
P06 149.7 14.3% (-56.6%, 85.3%) 844.5 0.529 (0.41, 0.63)
P07 136.0 17.3% (-60.1%, 94.7%) 693.0 0.646 (0.541, 0.73)
P08 114.1 11.7% (-46.1%, 69.5%) 695.9 0.643 (0.575, 0.701)
P09 26.8 0.7% (-67.9%, 69.4%) 459.0 0.807 (0.713, 0.872)
P10 138.7 17.9% (-67.7%, 103.4%) 836.2 0.596 (0.455, 0.708)
P02 P03 50.0 1.1% (-60.1%, 62.4%) 648.8 0.697 (0.585, 0.784)
P04 34.2 0% (-52.2%, 52.1%) 518.2 0.818 (0.769, 0.857)
P05 100.4 7.4% (-57.2%, 72%) 765.6 0.566 (0.442, 0.668)
P06 111.3 10.4% (-55.4%, 76.2%) 759.2 0.573 (0.451, 0.674)
P07 94.4 12% (-53.1%, 77.1%) 660.2 0.646 (0.531, 0.738)
P08 84.5 6.6% (-49.9%, 63.1%) 652.9 0.659 (0.589, 0.72)
P09 -13.5 -4.1% (-59.6%, 51.4%) 314.9 0.893 (0.833, 0.932)
P10 98.8 14% (-73.9%, 101.9%) 813.9 0.587 (0.432, 0.709)
P03 P04 -1.0 3% (-47.8%, 53.9%) 179.3 0.972 (0.957, 0.981)
P05 53.8 8% (-40.7%, 56.6%) 352.0 0.861 (0.806, 0.901)
P06 62.8 10.5% (-36.7%, 57.7%) 368.6 0.849 (0.788, 0.893)
P07 62.7 13.5% (-52.8%, 79.8%) 369.0 0.852 (0.79, 0.897)
P08 36.8 5.7% (-39.7%, 51.2%) 318.9 0.89 (0.845, 0.923)
P09 24.0 2.6% (-65.2%, 70.5%) 475.8 0.785 (0.679, 0.859)
P10 44.6 13.1% (-58.7%, 85%) 435.0 0.843 (0.762, 0.898)
P04 P05 52.1 5.3% (-53.2%, 63.8%) 314.7 0.883 (0.837, 0.917)
P06 61.1 8% (-50.3%, 66.3%) 328.7 0.872 (0.821, 0.91)
P07 54.8 10.1% (-56.3%, 76.5%) 260.3 0.92 (0.886, 0.944)
P08 47.0 6.3% (-38.6%, 51.2%) 303.1 0.893 (0.865, 0.916)
P09 16.1 -2.3% (-79.9%, 75.2%) 432.5 0.817 (0.724, 0.88)
P10 41.0 9.7% (-69.1%, 88.5%) 325.2 0.908 (0.858, 0.941)
P05 P06 9.0 3.1% (-32.9%, 39.2%) 140.7 0.972 (0.958, 0.982)
P07 8.0 6% (-48.9%, 60.9%) 303.9 0.879 (0.821, 0.919)
P08 -11.2 -0.8% (-33%, 31.4%) 144.3 0.971 (0.956, 0.981)
P09 -23.7 -3.4% (-62.8%, 55.9%) 310.5 0.882 (0.818, 0.924)
P10 -16.5 5.9% (-58.3%, 70%) 333.4 0.885 (0.828, 0.923)
P06 P07 -1.0 2% (-61.1%, 65.1%) 359.6 0.833 (0.754, 0.888)
P08 -18.7 -3.7% (-42.4%, 35%) 157.2 0.965 (0.947, 0.977)
P09 -35.5 -7% (-65.9%, 51.8%) 313.4 0.876 (0.81, 0.92)
P10 -22.5 3.6% (-61.2%, 68.5%) 359.7 0.867 (0.801, 0.912)
P07 P08 -28.7 -6.9% (-58.2%, 44.4%) 234.7 0.921 (0.882, 0.948)
P09 -36.2 -9.5% (-80.7%, 61.7%) 430.8 0.774 (0.661, 0.853)
P10 -25.6 -0.5% (-71.1%, 70%) 327.2 0.895 (0.839, 0.932)
P08 P09 -15.1 -3.5% (-66.7%, 59.7%) 373.7 0.833 (0.746, 0.893)
P10 17.6 10.1% (-57.3%, 77.5%) 274.6 0.915 (0.868, 0.945)
P09 P10 17.1 7.4% (-46.4%, 61.2%) 264.2 0.924 (0.88, 0.953)
VIII P01 P02 31.1 5.2% (-16.3%, 26.8%) 178.5 0.983 (0.978, 0.987)
P03 85.1 6.9% (-59.1%, 72.9%) 659.9 0.738 (0.64, 0.812)
P04 79.2 6.7% (-49.1%, 62.5%) 632.7 0.756 (0.7, 0.804)
P05 152.3 15.5% (-61.6%, 92.7%) 908.9 0.516 (0.388, 0.624)
P06 163.2 16.7% (-59.3%, 92.7%) 903.7 0.508 (0.382, 0.615)
P07 132.0 16% (-57.2%, 89.2%) 695.4 0.655 (0.546, 0.742)
P08 124.6 13.7% (-49.2%, 76.7%) 763.0 0.604 (0.528, 0.67)
P09 40.9 1.4% (-61.2%, 64%) 461.0 0.778 (0.686, 0.846)
P10 168.8 19.5% (-75%, 113.9%) 970.6 0.471 (0.317, 0.6)
P02 P03 45.7 0.9% (-54.7%, 56.5%) 581.8 0.764 (0.67, 0.834)
P04 38.4 0.7% (-51.3%, 52.7%) 514.8 0.815 (0.766, 0.855)
P05 101.5 9.4% (-57%, 75.8%) 730.3 0.601 (0.478, 0.701)
P06 114.0 11.3% (-58.6%, 81.3%) 726.5 0.608 (0.486, 0.707)
P07 85.1 9.6% (-53.3%, 72.4%) 598.6 0.709 (0.605, 0.789)
P08 88.5 8.2% (-50.9%, 67.4%) 660.0 0.663 (0.589, 0.726)
P09 3.3 -3.7% (-60.2%, 52.8%) 362.0 0.843 (0.767, 0.896)
P10 115.9 14.1% (-76.9%, 105.1%) 816.9 0.547 (0.389, 0.673)
P03 P04 7.5 0.3% (-31.7%, 32.3%) 176.9 0.973 (0.961, 0.982)
P05 49.0 9.1% (-25.6%, 43.7%) 240.5 0.939 (0.914, 0.957)
P06 72.6 11.9% (-38.4%, 62.2%) 357.9 0.864 (0.808, 0.905)
P07 58.6 11.4% (-34.7%, 57.5%) 253.5 0.93 (0.901, 0.951)
P08 47.7 9% (-26.6%, 44.6%) 315.0 0.894 (0.847, 0.927)
P09 39.4 2.3% (-59.5%, 64.1%) 445.3 0.79 (0.7, 0.855)
P10 66.8 14.4% (-51.8%, 80.5%) 382.6 0.865 (0.801, 0.91)
P04 P05 42.5 9.3% (-35.8%, 54.3%) 229.3 0.941 (0.913, 0.96)
P06 64.8 11.3% (-38.9%, 61.5%) 291.9 0.898 (0.853, 0.93)
P07 49.8 10.8% (-39.5%, 61.2%) 214.9 0.946 (0.92, 0.963)
P08 44.1 7.6% (-33%, 48.1%) 239.9 0.931 (0.91, 0.947)
P09 27.1 1.3% (-60.4%, 63%) 347.9 0.857 (0.79, 0.903)
P10 53.7 13.6% (-54.9%, 82%) 322.3 0.895 (0.841, 0.932)
P05 P06 23.5 3.3% (-45.2%, 51.9%) 294.9 0.897 (0.847, 0.931)
P07 8.8 2.4% (-41.5%, 46.3%) 226.7 0.943 (0.914, 0.962)
P08 7.1 0.7% (-39.4%, 40.8%) 273.5 0.914 (0.871, 0.943)
P09 1.6 -4.3% (-66.5%, 57.8%) 353.5 0.845 (0.767, 0.898)
P10 12.0 6.3% (-66.5%, 79.1%) 395.2 0.842 (0.758, 0.898)
P06 P07 -13.5 -0.7% (-46.8%, 45.4%) 228.7 0.94 (0.909, 0.96)
P08 -20.6 -2.9% (-43.2%, 37.4%) 212.0 0.943 (0.914, 0.962)
P09 -25.6 -7.9% (-70.2%, 54.5%) 330.8 0.85 (0.77, 0.904)
P10 -2.8 4.5% (-65%, 74%) 270.8 0.924 (0.881, 0.952)
P07 P08 -9.0 -2.4% (-45%, 40.1%) 227.0 0.939 (0.908, 0.96)
P09 -15.1 -7.3% (-71.6%, 57%) 345.2 0.843 (0.762, 0.899)
P10 -0.1 2.3% (-63.6%, 68.2%) 292.4 0.915 (0.866, 0.946)
P08 P09 -9.0 -5.9% (-63.2%, 51.4%) 309.4 0.875 (0.81, 0.919)
P10 21.9 7.8% (-58.9%, 74.5%) 282.7 0.906 (0.855, 0.939)
P09 P10 15.1 6.7% (-42.3%, 55.7%) 220.8 0.93 (0.89, 0.956)

References

Raunig, David L, Lisa M McShane, Gene Pennello, Constantine Gatsonis, Paul L Carson, James T Voyvodic, Richard L Wahl, et al. 2014. “Quantitative Imaging Biomarkers: A Review of Statistical Methods for Technical Performance Assessment.” Statistical Methods in Medical Research 24 (1): 27–67. https://doi.org/10.1177/0962280214537344.