Section

TCGA-PDAC correlations

Correlograms

Two versions as requested. Notice the label colors of the genes do not match what is currently in the poster. The posters version of this plot contained both TCGA (including the non-PDACs) and CPTAC individuals; so we lost quite a bit of power for the survival models which is why only FZD8 is significant. If you want to keep this plot a few recomenndations: 1) drop the label colors, or 2) use a p < 0.1 for the labels as the colored labels for ‘weak-evidence’ of effecting prognosis.

Gene data

Mouse Survivial

For some reason I have 2 fewer animals than what is in the poster; Double check

## 
##          KPC KPC-Fzd6 Het  KPC-Fzd6 KO 
##           19           16           16

CPTAC Survivial by FZD6 expression

With and without labels

## 
## High  Low  Mid 
##   34   34   66

8 year survivial probability

This differs from what is in the poster as that plot still contained the non PDAC persons, this one is the updated version.

Test for 3B

p = 0.048 using a Fisher’s exact test; significantly different

## 
##  Fisher's Exact Test for Count Data
## 
## data:  df$geno and df$pres
## p-value = 0.04762
## alternative hypothesis: true odds ratio is not equal to 1
## 95 percent confidence interval:
##  0.6944485       Inf
## sample estimates:
## odds ratio 
##        Inf