#Table 1

table1(~Gender_Legal_Sex+age_10year+htn+dm+cad+chf+copd+nsaid+beta_blockers+statins+ace_arb+ppi+diur+immunosuppressant+vaccine_ACTUAL+renal_group2+cancer+pre_cre_freq_cat+pre_inpt_freq_cat+as.factor(new_renal_outcome_status)+as.factor(new_dm_outcome_status)+as.factor(new_cv_outcome_status)+sglt2i+ccb+statins+
                   pre_HGB_365days_cat+pre_ALB_365days_cat+pre_WBC_365days_cat+pre_sodium_365days_cat+pre_potassium_365days_cat+pre_urine_proetein_ratio_365days_cat|case,data=matched_final)

	0 (N=840)	1 (N=840)	Overall (N=1680)
Gender_Legal_Sex
Female	450 (53.6%)	430 (51.2%)	880 (52.4%)
Male	390 (46.4%)	410 (48.8%)	800 (47.6%)
age_10year
Mean (SD)	7.34 (1.33)	7.32 (1.33)	7.33 (1.33)
Median [Min, Max]	7.50 [2.15, 10.0]	7.50 [2.18, 10.4]	7.50 [2.15, 10.4]
htn
0	130 (15.5%)	128 (15.2%)	258 (15.4%)
1	710 (84.5%)	712 (84.8%)	1422 (84.6%)
dm
0	446 (53.1%)	432 (51.4%)	878 (52.3%)
1	394 (46.9%)	408 (48.6%)	802 (47.7%)
cad
0	383 (45.6%)	407 (48.5%)	790 (47.0%)
1	457 (54.4%)	433 (51.5%)	890 (53.0%)
chf
0	751 (89.4%)	752 (89.5%)	1503 (89.5%)
1	89 (10.6%)	88 (10.5%)	177 (10.5%)
copd
0	689 (82.0%)	697 (83.0%)	1386 (82.5%)
1	151 (18.0%)	143 (17.0%)	294 (17.5%)
nsaid
0	673 (80.1%)	675 (80.4%)	1348 (80.2%)
1	167 (19.9%)	165 (19.6%)	332 (19.8%)
beta_blockers
0	495 (58.9%)	483 (57.5%)	978 (58.2%)
1	345 (41.1%)	357 (42.5%)	702 (41.8%)
statins
0	424 (50.5%)	420 (50.0%)	844 (50.2%)
1	416 (49.5%)	420 (50.0%)	836 (49.8%)
ace_arb
0	515 (61.3%)	498 (59.3%)	1013 (60.3%)
1	325 (38.7%)	342 (40.7%)	667 (39.7%)
ppi
0	568 (67.6%)	568 (67.6%)	1136 (67.6%)
1	272 (32.4%)	272 (32.4%)	544 (32.4%)
diur
0	530 (63.1%)	524 (62.4%)	1054 (62.7%)
1	310 (36.9%)	316 (37.6%)	626 (37.3%)
immunosuppressant
0	792 (94.3%)	796 (94.8%)	1588 (94.5%)
1	48 (5.7%)	44 (5.2%)	92 (5.5%)
vaccine_ACTUAL
0	126 (15.0%)	113 (13.5%)	239 (14.2%)
1	714 (85.0%)	727 (86.5%)	1441 (85.8%)
renal_group2
eGFR <30, no ESKD	58 (6.9%)	54 (6.4%)	112 (6.7%)
eGFR 30-44.9, no ESKD	177 (21.1%)	194 (23.1%)	371 (22.1%)
eGFR 45-59.9, no ESKD	506 (60.2%)	498 (59.3%)	1004 (59.8%)
ESKD	99 (11.8%)	94 (11.2%)	193 (11.5%)
cancer
0	473 (56.3%)	486 (57.9%)	959 (57.1%)
1	367 (43.7%)	354 (42.1%)	721 (42.9%)
pre_cre_freq_cat
1	181 (21.5%)	176 (21.0%)	357 (21.3%)
2-4	659 (78.5%)	664 (79.0%)	1323 (78.8%)
pre_inpt_freq_cat
0	617 (73.5%)	621 (73.9%)	1238 (73.7%)
1-2	124 (14.8%)	118 (14.0%)	242 (14.4%)
3+	99 (11.8%)	101 (12.0%)	200 (11.9%)
as.factor(new_renal_outcome_status)
0	790 (94.0%)	811 (96.5%)	1601 (95.3%)
1	50 (6.0%)	29 (3.5%)	79 (4.7%)
as.factor(new_dm_outcome_status)
0	814 (96.9%)	823 (98.0%)	1637 (97.4%)
1	26 (3.1%)	17 (2.0%)	43 (2.6%)
as.factor(new_cv_outcome_status)
0	686 (81.7%)	688 (81.9%)	1374 (81.8%)
1	154 (18.3%)	152 (18.1%)	306 (18.2%)
sglt2i
0	801 (95.4%)	791 (94.2%)	1592 (94.8%)
1	39 (4.6%)	49 (5.8%)	88 (5.2%)
ccb
0	582 (69.3%)	580 (69.0%)	1162 (69.2%)
1	258 (30.7%)	260 (31.0%)	518 (30.8%)
pre_HGB_365days_cat
Missing	40 (4.8%)	82 (9.8%)	122 (7.3%)
Q1	200 (23.8%)	192 (22.9%)	392 (23.3%)
Q2	204 (24.3%)	187 (22.3%)	391 (23.3%)
Q3	174 (20.7%)	189 (22.5%)	363 (21.6%)
Q4	222 (26.4%)	190 (22.6%)	412 (24.5%)
pre_ALB_365days_cat
Missing	136 (16.2%)	119 (14.2%)	255 (15.2%)
Q1	162 (19.3%)	261 (31.1%)	423 (25.2%)
Q2	179 (21.3%)	154 (18.3%)	333 (19.8%)
Q3	212 (25.2%)	183 (21.8%)	395 (23.5%)
Q4	151 (18.0%)	123 (14.6%)	274 (16.3%)
pre_WBC_365days_cat
Missing	40 (4.8%)	82 (9.8%)	122 (7.3%)
Q1	191 (22.7%)	233 (27.7%)	424 (25.2%)
Q2	189 (22.5%)	166 (19.8%)	355 (21.1%)
Q3	209 (24.9%)	167 (19.9%)	376 (22.4%)
Q4	211 (25.1%)	192 (22.9%)	403 (24.0%)
pre_sodium_365days_cat
Missing	7 (0.8%)	5 (0.6%)	12 (0.7%)
Q1	237 (28.2%)	293 (34.9%)	530 (31.5%)
Q2	211 (25.1%)	197 (23.5%)	408 (24.3%)
Q3	221 (26.3%)	205 (24.4%)	426 (25.4%)
Q4	164 (19.5%)	140 (16.7%)	304 (18.1%)
pre_potassium_365days_cat
Missing	12 (1.4%)	15 (1.8%)	27 (1.6%)
Q1	224 (26.7%)	234 (27.9%)	458 (27.3%)
Q2	204 (24.3%)	196 (23.3%)	400 (23.8%)
Q3	198 (23.6%)	209 (24.9%)	407 (24.2%)
Q4	202 (24.0%)	186 (22.1%)	388 (23.1%)
pre_urine_proetein_ratio_365days_cat
<=0.1	14 (1.7%)	4 (0.5%)	18 (1.1%)
>0.1	30 (3.6%)	19 (2.3%)	49 (2.9%)
Not checked	796 (94.8%)	817 (97.3%)	1613 (96.0%)

1.Univariate coxph new_renal_outcome

Characteristic	N	HR¹	95% CI¹	p-value
case	1,680
0		—	—
1		0.57	0.36, 0.91	0.017
age_bl	1,680	1.01	0.99, 1.03	0.403
vaccine_ACTUAL	1,680
0		—	—
1		1.14	0.58, 2.22	0.702
Gender_Legal_Sex	1,680
Female		—	—
Male		1.07	0.69, 1.67	0.748
htn	1,680
0		—	—
1		1.63	0.78, 3.39	0.191
dm	1,680
0		—	—
1		1.19	0.77, 1.83	0.427
cad	1,680
0		—	—
1		1.11	0.72, 1.73	0.632
chf	1,680
0		—	—
1		1.39	0.75, 2.60	0.298
copd	1,680
0		—	—
1		1.50	0.91, 2.48	0.110
subclass	1,680	1.00	1.00, 1.00	0.588
¹ HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph new_renal_outcome

Characteristic	N	HR¹	95% CI¹	p-value
case	1,680
0		—	—
1		0.57	0.36, 0.90	0.017
age_bl	1,680	1.00	0.98, 1.02	0.662
vaccine_ACTUAL	1,680
0		—	—
1		1.07	0.55, 2.12	0.834
Gender_Legal_Sex	1,680
Female		—	—
Male		1.12	0.71, 1.75	0.626
htn	1,680
0		—	—
1		1.47	0.64, 3.39	0.361
dm	1,680
0		—	—
1		1.09	0.67, 1.77	0.721
cad	1,680
0		—	—
1		0.89	0.54, 1.45	0.629
chf	1,680
0		—	—
1		1.22	0.63, 2.37	0.553
copd	1,680
0		—	—
1		1.40	0.82, 2.38	0.212
¹ HR = Hazard Ratio, CI = Confidence Interval

2.Univariate coxph new_dm_outcome

Characteristic	N	HR¹	95% CI¹	p-value
case	1,680
0		—	—
1		0.65	0.36, 1.19	0.162
age_bl	1,680	0.98	0.96, 1.00	0.070
vaccine_ACTUAL	1,680
0		—	—
1		1.02	0.43, 2.43	0.965
Gender_Legal_Sex	1,680
Female		—	—
Male		1.05	0.57, 1.93	0.881
htn	1,680
0		—	—
1		1.78	0.64, 4.98	0.270
cad	1,680
0		—	—
1		0.84	0.46, 1.56	0.586
chf	1,680
0		—	—
1		1.97	0.85, 4.55	0.112
copd	1,680
0		—	—
1		1.25	0.61, 2.56	0.544
subclass	1,680	1.00	1.00, 1.00	0.116
¹ HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph new_dm_outcome

Characteristic	N	HR¹	95% CI¹	p-value
case	1,680
0		—	—
1		0.64	0.35, 1.17	0.147
age_bl	1,680	0.98	0.96, 1.00	0.054
vaccine_ACTUAL	1,680
0		—	—
1		1.10	0.43, 2.85	0.842
Gender_Legal_Sex	1,680
Female		—	—
Male		1.07	0.59, 1.97	0.816
htn	1,680
0		—	—
1		2.19	0.72, 6.66	0.169
cad	1,680
0		—	—
1		0.65	0.32, 1.32	0.230
chf	1,680
0		—	—
1		2.29	0.87, 6.06	0.094
copd	1,680
0		—	—
1		1.23	0.57, 2.65	0.596
¹ HR = Hazard Ratio, CI = Confidence Interval

3.Univariate coxph new_cv_outcome

Characteristic	N	HR¹	95% CI¹	p-value
case	1,680
0		—	—
1		0.99	0.79, 1.24	0.938
age_bl	1,680	1.01	1.00, 1.02	0.011
vaccine_ACTUAL	1,680
0		—	—
1		0.96	0.70, 1.32	0.800
Gender_Legal_Sex	1,680
Female		—	—
Male		1.08	0.86, 1.36	0.497
htn	1,680
0		—	—
1		2.27	1.50, 3.43	<0.001
dm	1,680
0		—	—
1		1.77	1.41, 2.22	<0.001
copd	1,680
0		—	—
1		1.74	1.33, 2.26	<0.001
subclass	1,680	1.00	1.00, 1.00	0.178
¹ HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph new_cv_outcome

Characteristic	N	HR¹	95% CI¹	p-value
case	1,680
0		—	—
1		0.98	0.78, 1.23	0.882
age_bl	1,680	1.01	1.00, 1.02	0.078
vaccine_ACTUAL	1,680
0		—	—
1		0.87	0.63, 1.19	0.377
Gender_Legal_Sex	1,680
Female		—	—
Male		1.08	0.86, 1.36	0.492
htn	1,680
0		—	—
1		1.65	1.06, 2.56	0.026
dm	1,680
0		—	—
1		1.57	1.24, 1.99	<0.001
copd	1,680
0		—	—
1		1.56	1.19, 2.04	0.001
¹ HR = Hazard Ratio, CI = Confidence Interval

Univariate coxph death 30 days

Characteristic	N	HR¹	95% CI¹	p-value
case	1,680
0		—	—
1		4.84	1.84, 12.8	0.001
age_bl	1,680	1.07	1.02, 1.11	0.005
vaccine_ACTUAL	1,680
0		—	—
1		0.20	0.10, 0.42	<0.001
Gender_Legal_Sex	1,680
Female		—	—
Male		1.18	0.57, 2.45	0.657
htn	1,680
0		—	—
1		0.57	0.24, 1.32	0.187
dm	1,680
0		—	—
1		0.67	0.32, 1.40	0.286
cad	1,680
0		—	—
1		1.26	0.60, 2.63	0.538
chf	1,680
0		—	—
1		0.63	0.15, 2.66	0.529
copd	1,680
0		—	—
1		2.13	0.97, 4.66	0.059
subclass	1,680	1.00	1.00, 1.00	0.059
¹ HR = Hazard Ratio, CI = Confidence Interval

Multivariate coxph death 30 days

Characteristic	N	HR¹	95% CI¹	p-value
case	1,680
0		—	—
1		4.71	1.85, 12.0	0.001
age_bl	1,680	1.07	1.03, 1.11	<0.001
vaccine_ACTUAL	1,680
0		—	—
1		0.15	0.07, 0.30	<0.001
Gender_Legal_Sex	1,680
Female		—	—
Male		1.20	0.56, 2.58	0.636
htn	1,680
0		—	—
1		0.41	0.18, 0.92	0.030
dm	1,680
0		—	—
1		0.68	0.29, 1.58	0.369
copd	1,680
0		—	—
1		2.82	1.22, 6.51	0.015
cad	1,680
0		—	—
1		1.62	0.81, 3.25	0.171
chf	1,680
0		—	—
1		0.52	0.11, 2.44	0.405
¹ HR = Hazard Ratio, CI = Confidence Interval

hosp_outcome 30 days

## Registered S3 method overwritten by 'gdata':
##   method         from     
##   reorder.factor DescTools

## 
##  
##    Cell Contents
## |-------------------------|
## |                       N |
## | Chi-square contribution |
## |           N / Row Total |
## |           N / Col Total |
## |         N / Table Total |
## |-------------------------|
## 
##  
## Total Observations in Table:  1680 
## 
##  
##                            | matched_final$case 
## matched_final$hosp_outcome |         0 |         1 | Row Total | 
## ---------------------------|-----------|-----------|-----------|
##                          0 |       840 |       765 |      1605 | 
##                            |     1.752 |     1.752 |           | 
##                            |     0.523 |     0.477 |     0.955 | 
##                            |     1.000 |     0.911 |           | 
##                            |     0.500 |     0.455 |           | 
## ---------------------------|-----------|-----------|-----------|
##                          1 |         0 |        75 |        75 | 
##                            |    37.500 |    37.500 |           | 
##                            |     0.000 |     1.000 |     0.045 | 
##                            |     0.000 |     0.089 |           | 
##                            |     0.000 |     0.045 |           | 
## ---------------------------|-----------|-----------|-----------|
##               Column Total |       840 |       840 |      1680 | 
##                            |     0.500 |     0.500 |           | 
## ---------------------------|-----------|-----------|-----------|
## 
##

Characteristic	N	HR¹	95% CI¹	p-value
age_bl	1,680	1.02	1.00, 1.04	0.021
vaccine_ACTUAL	1,680
0		—	—
1		0.78	0.43, 1.42	0.417
Gender_Legal_Sex	1,680
Female		—	—
Male		1.07	0.68, 1.69	0.762
htn	1,680
0		—	—
1		2.58	1.04, 6.36	0.040
dm	1,680
0		—	—
1		1.56	0.99, 2.47	0.054
copd	1,680
0		—	—
1		1.61	0.96, 2.70	0.069
subclass	1,680	1.00	1.00, 1.00	0.509
¹ HR = Hazard Ratio, CI = Confidence Interval

Univariate logistic regression critical illness 30 days hospitalized

## 
##  
##    Cell Contents
## |-------------------------|
## |                       N |
## | Chi-square contribution |
## |           N / Row Total |
## |           N / Col Total |
## |         N / Table Total |
## |-------------------------|
## 
##  
## Total Observations in Table:  75 
## 
##  
##                                       | matched_final$case 
## matched_final$Critical_illness_30days |         0 |         1 | Row Total | 
## --------------------------------------|-----------|-----------|-----------|
##                                     0 |         0 |        63 |        63 | 
##                                       |       NaN |     0.000 |           | 
##                                       |     0.000 |     1.000 |     0.840 | 
##                                       |       NaN |     0.840 |           | 
##                                       |     0.000 |     0.840 |           | 
## --------------------------------------|-----------|-----------|-----------|
##                                     1 |         0 |        12 |        12 | 
##                                       |       NaN |     0.000 |           | 
##                                       |     0.000 |     1.000 |     0.160 | 
##                                       |       NaN |     0.160 |           | 
##                                       |     0.000 |     0.160 |           | 
## --------------------------------------|-----------|-----------|-----------|
##                          Column Total |         0 |        75 |        75 | 
##                                       |     0.000 |     1.000 |           | 
## --------------------------------------|-----------|-----------|-----------|
## 
##

Characteristic	N	OR¹	95% CI¹	p-value
age_bl	75	1.03	0.97, 1.09	0.389
vaccine_ACTUAL	75
0		—	—
1		0.57	0.14, 2.88	0.448
Gender_Legal_Sex	75
Female		—	—
Male		1.03	0.29, 3.63	0.960
htn	75
0		—	—
1		0.25	0.04, 2.07	0.155
dm	75
0		—	—
1		0.66	0.19, 2.32	0.508
cad	75
0		—	—
1		0.81	0.23, 2.99	0.735
chf	75
0		—	—
1		1.20	0.17, 5.60	0.831
copd	75
0		—	—
1		0.98	0.20, 3.77	0.977
¹ OR = Odds Ratio, CI = Confidence Interval

aim12_anlysis

2024-09-05

1.Univariate coxph new_renal_outcome

Multivariate coxph new_renal_outcome

2.Univariate coxph new_dm_outcome

Multivariate coxph new_dm_outcome

3.Univariate coxph new_cv_outcome

Multivariate coxph new_cv_outcome

Univariate coxph death 30 days

Multivariate coxph death 30 days

hosp_outcome 30 days

Univariate logistic regression critical illness 30 days hospitalized