Tableone

Full Sample Description

Overall
n 2559
age_at_visit (mean (SD)) 58.95 (14.20)
education (mean (SD)) 15.87 (2.63)
ftldcdr_sb (mean (SD)) 4.93 (5.37)
sex = Male (%) 1270 ( 49.6)
ftldcdr_glob (%)
0 783 ( 30.6)
0.5 450 ( 17.6)
1 648 ( 25.3)
2 546 ( 21.3)
3 132 ( 5.2)
genetic_factor (%)
C9 282 ( 14.1)
C9 and GRN 3 ( 0.2)
GRN 130 ( 6.5)
MAPT 129 ( 6.5)
none 1449 ( 72.7)
family_gene.controlvscase = Carrier (%) 22 (100.0)
Overall
n 2559
moca_total (mean (SD)) 21.92 (6.89)
uds3_ef (mean (SD)) -1.21 (1.45)
traila_ratio (mean (SD)) 0.76 (0.42)
trailb_ratio (mean (SD)) 0.32 (0.20)
dig_fwd_sum (mean (SD)) 7.35 (2.76)
dig_back_sum (mean (SD)) 5.74 (2.84)
mint_total (mean (SD)) 23.70 (8.25)
flu_animal (mean (SD)) 16.10 (8.76)
flu_veg (mean (SD)) 10.40 (5.95)
flu_fwords (mean (SD)) 10.49 (6.05)
flu_lwords (mean (SD)) 9.94 (5.79)
benson_copy (mean (SD)) 14.42 (3.06)
benson_delay (mean (SD)) 9.61 (4.64)
craft_v_immed (mean (SD)) 16.28 (9.20)
craft_v_delay (mean (SD)) 13.77 (9.15)

Sample by genetic mutation status

C9 C9 and GRN GRN MAPT none p test
n 282 3 130 129 1449
age_at_visit (mean (SD)) 51.20 (14.62) 33.67 (13.65) 56.11 (13.22) 45.28 (13.68) 61.50 (12.83) <0.001
education (mean (SD)) 15.72 (2.50) 14.00 (2.00) 15.48 (2.91) 15.52 (2.49) 16.00 (2.61) 0.028
ftldcdr_sb (mean (SD)) 3.64 (5.54) 0.00 (0.00) 4.70 (6.75) 3.24 (5.38) 5.35 (5.20) <0.001
sex = Male (%) 121 ( 42.9) 1 ( 33.3) 63 ( 48.5) 54 ( 41.9) 749 (51.7) 0.026
ftldcdr_glob (%) <0.001
0 147 ( 52.1) 3 (100.0) 65 ( 50.0) 69 ( 53.5) 336 (23.2)
0.5 40 ( 14.2) 0 ( 0.0) 13 ( 10.0) 24 ( 18.6) 278 (19.2)
1 33 ( 11.7) 0 ( 0.0) 22 ( 16.9) 11 ( 8.5) 421 (29.1)
2 53 ( 18.8) 0 ( 0.0) 17 ( 13.1) 20 ( 15.5) 340 (23.5)
3 9 ( 3.2) 0 ( 0.0) 13 ( 10.0) 5 ( 3.9) 74 ( 5.1)
family_gene.controlvscase = Carrier (%) 12 (100.0) 0 ( NaN) 7 (100.0) 2 (100.0) 0 ( NaN) NA
Overall C9 C9 and GRN GRN MAPT none p test
n 2559 282 3 130 129 1449
moca_total (mean (SD)) 21.92 (6.89) 24.35 (5.96) 28.00 (1.00) 22.46 (7.78) 23.56 (6.59) 21.36 (6.76) <0.001
uds3_ef (mean (SD)) -1.21 (1.45) -0.62 (1.35) -0.18 (0.24) -0.77 (1.48) -0.50 (1.42) -1.42 (1.39) <0.001
traila_ratio (mean (SD)) 0.76 (0.42) 0.89 (0.41) 0.64 (0.08) 0.88 (0.42) 1.00 (0.47) 0.71 (0.41) <0.001
trailb_ratio (mean (SD)) 0.32 (0.20) 0.38 (0.18) 0.33 (0.06) 0.37 (0.18) 0.44 (0.22) 0.29 (0.20) <0.001
dig_fwd_sum (mean (SD)) 7.35 (2.76) 8.08 (2.72) 10.33 (0.58) 7.36 (2.89) 8.29 (2.51) 7.19 (2.72) <0.001
dig_back_sum (mean (SD)) 5.74 (2.84) 6.58 (2.84) 8.67 (1.53) 5.95 (3.06) 7.03 (2.85) 5.49 (2.74) <0.001
mint_total (mean (SD)) 23.70 (8.25) 26.75 (4.65) 29.00 (NA) 25.73 (6.79) 24.15 (6.74) 22.94 (8.80) NA
flu_animal (mean (SD)) 16.10 (8.76) 19.81 (7.81) 24.33 (2.52) 19.00 (9.06) 19.22 (7.87) 14.78 (8.56) <0.001
flu_veg (mean (SD)) 10.40 (5.95) 12.39 (5.28) 16.67 (3.06) 12.56 (6.20) 12.08 (5.17) 9.67 (5.92) <0.001
flu_fwords (mean (SD)) 10.49 (6.05) 12.28 (5.63) 14.00 (4.36) 12.43 (7.25) 12.71 (6.57) 9.75 (5.79) <0.001
flu_lwords (mean (SD)) 9.94 (5.79) 11.70 (5.57) 11.33 (3.51) 11.15 (6.50) 12.26 (6.12) 9.26 (5.52) <0.001
benson_copy (mean (SD)) 14.42 (3.06) 15.02 (2.07) 15.33 (0.58) 14.43 (3.10) 15.31 (2.13) 14.23 (3.15) <0.001
benson_delay (mean (SD)) 9.61 (4.64) 11.11 (3.43) 13.33 (2.08) 10.34 (3.95) 10.82 (4.84) 9.09 (4.79) <0.001
craft_v_immed (mean (SD)) 16.28 (9.20) 19.50 (8.55) 19.33 (5.69) 18.28 (8.19) 18.56 (8.70) 15.31 (9.17) <0.001
craft_v_delay (mean (SD)) 13.77 (9.15) 17.48 (8.32) 16.00 (5.20) 15.92 (8.33) 15.78 (9.38) 12.75 (9.06) <0.001

Sample by baseline CDR+NACC-FTLD Global

0 0.5 1 2 3 p test
n 783 450 648 546 132
age_at_visit (mean (SD)) 45.25 (13.57) 63.53 (11.51) 65.83 (7.92) 65.09 (9.19) 65.42 (9.96) <0.001
education (mean (SD)) 16.07 (2.48) 15.90 (2.70) 16.00 (2.65) 15.53 (2.66) 15.45 (2.91) 0.001
ftldcdr_sb (mean (SD)) 0.00 (0.00) 1.94 (0.99) 5.40 (1.48) 10.44 (2.63) 19.21 (3.31) <0.001
sex = Male (%) 308 (39.3) 219 (48.7) 384 ( 59.3) 311 ( 57.0) 48 ( 36.4) <0.001
genetic_factor (%) <0.001
C9 147 (23.7) 40 (11.3) 33 ( 6.8) 53 ( 12.3) 9 ( 8.9)
C9 and GRN 3 ( 0.5) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0)
GRN 65 (10.5) 13 ( 3.7) 22 ( 4.5) 17 ( 4.0) 13 ( 12.9)
MAPT 69 (11.1) 24 ( 6.8) 11 ( 2.3) 20 ( 4.7) 5 ( 5.0)
none 336 (54.2) 278 (78.3) 421 ( 86.4) 340 ( 79.1) 74 ( 73.3)
family_gene.controlvscase = Carrier (%) 0 ( NaN) 0 ( NaN) 9 (100.0) 10 (100.0) 3 (100.0) NA
Overall 0 0.5 1 2 3 p test
n 2559 783 450 648 546 132
moca_total (mean (SD)) 21.92 (6.89) 27.32 (2.21) 23.56 (4.19) 19.45 (5.88) 15.80 (6.91) 8.68 (5.81) <0.001
uds3_ef (mean (SD)) -1.21 (1.45) 0.23 (0.74) -1.22 (1.05) -1.96 (1.08) -2.47 (0.92) -2.84 (0.90) <0.001
traila_ratio (mean (SD)) 0.76 (0.42) 1.11 (0.37) 0.70 (0.30) 0.55 (0.29) 0.46 (0.26) 0.30 (0.22) <0.001
trailb_ratio (mean (SD)) 0.32 (0.20) 0.47 (0.17) 0.27 (0.14) 0.21 (0.14) 0.17 (0.12) 0.12 (0.15) <0.001
dig_fwd_sum (mean (SD)) 7.35 (2.76) 8.98 (2.37) 7.07 (2.38) 6.55 (2.71) 6.04 (2.45) 5.49 (2.30) <0.001
dig_back_sum (mean (SD)) 5.74 (2.84) 7.73 (2.29) 5.71 (2.26) 4.76 (2.54) 3.86 (2.36) 2.33 (2.28) <0.001
mint_total (mean (SD)) 23.70 (8.25) 28.51 (1.61) 24.34 (7.21) 21.91 (9.17) 20.76 (9.49) 19.29 (8.93) <0.001
flu_animal (mean (SD)) 16.10 (8.76) 24.01 (5.72) 16.34 (6.81) 11.70 (6.57) 9.02 (6.01) 5.21 (4.47) <0.001
flu_veg (mean (SD)) 10.40 (5.95) 15.46 (4.16) 10.43 (4.65) 7.57 (4.83) 5.78 (4.13) 4.28 (5.17) <0.001
flu_fwords (mean (SD)) 10.49 (6.05) 15.35 (4.63) 10.52 (4.73) 7.98 (4.93) 5.94 (4.49) 3.48 (3.44) <0.001
flu_lwords (mean (SD)) 9.94 (5.79) 14.49 (4.36) 10.02 (4.88) 7.53 (4.78) 5.57 (4.17) 3.19 (3.04) <0.001
benson_copy (mean (SD)) 14.42 (3.06) 15.67 (1.29) 14.80 (2.20) 13.99 (3.21) 12.92 (4.05) 9.51 (5.25) <0.001
benson_delay (mean (SD)) 9.61 (4.64) 12.78 (2.59) 10.09 (3.65) 7.96 (4.42) 6.09 (4.79) 3.89 (3.42) <0.001
craft_v_immed (mean (SD)) 16.28 (9.20) 22.73 (6.54) 17.33 (8.16) 12.48 (8.15) 9.65 (7.57) 5.89 (6.56) <0.001
craft_v_delay (mean (SD)) 13.77 (9.15) 20.59 (6.65) 14.48 (8.08) 9.64 (7.72) 6.99 (6.98) 3.52 (4.93) <0.001

UDS Forrest plots (regressions)

##          ftldcdr_sb   Estimate     CI.low    CI.high
## 1              moca -0.5879184 -0.6134545 -0.5623822
## 2  uds-ef composite -0.5478974 -0.5781611 -0.5176336
## 3     trail b ratio -0.3553617 -0.3886509 -0.3220724
## 4     trail a ratio -0.2885095 -0.3193023 -0.2577167
## 5            ds fwd -0.2422995 -0.2744909 -0.2101082
## 6            ds bwd -0.3544093 -0.3847968 -0.3240218
## 7              mint -0.2612629 -0.2993843 -0.2231414
## 8           animals -0.4905436 -0.5199415 -0.4611457
## 9               veg -0.4454622 -0.4751724 -0.4157519
## 10        words (f) -0.4120403 -0.4413342 -0.3827463
## 11        words (l) -0.4029442 -0.4320911 -0.3737973
## 12      benson copy -0.2796925 -0.3096507 -0.2497343
## 13    benson recall -0.4102557 -0.4392742 -0.3812372
## 14     craft immed. -0.3865760 -0.4151680 -0.3579840
## 15      craft delay -0.3957941 -0.4245973 -0.3669908
##         psprs_total     Estimate      CI.low      CI.high
## 1              moca  0.071949452  0.01674157  0.127157336
## 2  uds-ef composite -0.238399242 -0.29520822 -0.181590260
## 3     trail b ratio -0.233234183 -0.27975304 -0.186715324
## 4     trail a ratio -0.191224367 -0.23753892 -0.144909810
## 5            ds fwd -0.044947072 -0.08692287 -0.002971273
## 6            ds bwd -0.146815670 -0.19195431 -0.101677027
## 7              mint  0.237006834  0.18548769  0.288525976
## 8           animals -0.050607737 -0.10405468  0.002839202
## 9               veg -0.002563708 -0.05287755  0.047750136
## 10        words (f) -0.157188288 -0.20512578 -0.109250799
## 11        words (l) -0.159025766 -0.20675245 -0.111299087
## 12      benson copy -0.287608843 -0.32703408 -0.248183603
## 13    benson recall  0.083429138  0.03702830  0.129829972
## 14     craft immed.  0.113920904  0.06734911  0.160492700
## 15      craft delay  0.117607538  0.06935507  0.165860007
##         updrs_score     Estimate      CI.low      CI.high
## 1              moca  0.078548045  0.02364202  0.133454075
## 2  uds-ef composite -0.218132427 -0.27388444 -0.162380413
## 3     trail b ratio -0.249662369 -0.29593744 -0.203387293
## 4     trail a ratio -0.194481089 -0.24001002 -0.148952156
## 5            ds fwd -0.048052511 -0.08940436 -0.006700662
## 6            ds bwd -0.134473534 -0.17907873 -0.089868336
## 7              mint  0.207769379  0.15798030  0.257558461
## 8           animals -0.056158623 -0.10905530 -0.003261948
## 9               veg -0.006160131 -0.05598594  0.043665674
## 10        words (f) -0.137743679 -0.18476986 -0.090717493
## 11        words (l) -0.153644936 -0.19997035 -0.107319527
## 12      benson copy -0.280334819 -0.31915400 -0.241515634
## 13    benson recall  0.061816683  0.01662413  0.107009238
## 14     craft immed.  0.108431136  0.06226143  0.154600845
## 15      craft delay  0.105434474  0.05805619  0.152812760
##          alsfrs_sum     Estimate      CI.low       CI.high
## 1              moca -0.053944678 -0.10764728 -0.0002420765
## 2  uds-ef composite  0.166790497  0.11119916  0.2223818332
## 3     trail b ratio  0.200602583  0.15510689  0.2460982750
## 4     trail a ratio  0.190104351  0.14305983  0.2371488693
## 5            ds fwd  0.054368326  0.01354903  0.0951876238
## 6            ds bwd  0.123581036  0.07918431  0.1679777672
## 7              mint -0.200723972 -0.25177275 -0.1496751985
## 8           animals  0.035344202 -0.01689928  0.0875876805
## 9               veg  0.004422006 -0.04509570  0.0539397152
## 10        words (f)  0.125563908  0.07913930  0.1719885183
## 11        words (l)  0.135512116  0.08955339  0.1814708391
## 12      benson copy  0.292859067  0.25629554  0.3294225899
## 13    benson recall -0.062505683 -0.10749589 -0.0175154731
## 14     craft immed. -0.104006469 -0.14888297 -0.0591299678
## 15      craft delay -0.101182444 -0.14758764 -0.0547772437
##           npi_total     Estimate       CI.low    CI.high
## 1              moca  0.103705014  0.050372097 0.15703793
## 2  uds-ef composite  0.073795748  0.021668992 0.12592250
## 3     trail b ratio  0.061950160  0.013979914 0.10992041
## 4     trail a ratio  0.052584479  0.004954105 0.10021485
## 5            ds fwd  0.036181971 -0.002059812 0.07442375
## 6            ds bwd  0.028908398 -0.012900722 0.07071752
## 7              mint  0.041499904 -0.006734340 0.08973415
## 8           animals  0.057969357  0.008481113 0.10745760
## 9               veg  0.039225784 -0.007260977 0.08571255
## 10        words (f)  0.048780910  0.004546641 0.09301518
## 11        words (l)  0.067394349  0.023142506 0.11164619
## 12      benson copy  0.104917958  0.066616743 0.14321917
## 13    benson recall -0.007137480 -0.051651863 0.03737690
## 14     craft immed. -0.009133067 -0.052670551 0.03440442
## 15      craft delay -0.023590649 -0.068371870 0.02119057
##           faq_total    Estimate       CI.low      CI.high
## 1              moca -0.09237027 -0.126342361 -0.058398181
## 2  uds-ef composite -0.13157064 -0.163967258 -0.099174021
## 3     trail b ratio -0.06153034 -0.089352595 -0.033708079
## 4     trail a ratio -0.04703942 -0.073504532 -0.020574308
## 5            ds fwd -0.01620046 -0.039902817  0.007501894
## 6            ds bwd -0.04962062 -0.075833598 -0.023407644
## 7              mint  0.03341363 -0.000345581  0.067172839
## 8           animals -0.06044458 -0.090897004 -0.029992161
## 9               veg -0.08085095 -0.109861120 -0.051840778
## 10        words (f) -0.05089730 -0.078671938 -0.023122654
## 11        words (l) -0.05420562 -0.081223324 -0.027187924
## 12      benson copy -0.03405761 -0.057490171 -0.010625045
## 13    benson recall -0.08679709 -0.114491437 -0.059102740
## 14     craft immed. -0.04319216 -0.070946541 -0.015437785
## 15      craft delay -0.06224799 -0.090270526 -0.034225464
##           snq_total   Estimate     CI.low   CI.high
## 1              moca 0.52222855 0.46830903 0.5761481
## 2  uds-ef composite 0.45268440 0.40044619 0.5049226
## 3     trail b ratio 0.19933963 0.14946181 0.2492175
## 4     trail a ratio 0.17915620 0.12994179 0.2283706
## 5            ds fwd 0.19323916 0.15339676 0.2330816
## 6            ds bwd 0.23052155 0.18716050 0.2738826
## 7              mint 0.19762156 0.14409056 0.2511526
## 8           animals 0.37921496 0.32916198 0.4292679
## 9               veg 0.31461573 0.26714625 0.3620852
## 10        words (f) 0.31433057 0.27000915 0.3586520
## 11        words (l) 0.32806885 0.28413984 0.3719978
## 12      benson copy 0.08124793 0.03944472 0.1230511
## 13    benson recall 0.13893200 0.09100664 0.1868574
## 14     craft immed. 0.28966476 0.24571697 0.3336126
## 15      craft delay 0.23897348 0.19383840 0.2841086
##     sboc_desc_total    Estimate      CI.low      CI.high
## 1              moca -0.29741517 -0.34926496 -0.245565381
## 2  uds-ef composite -0.16059801 -0.21316513 -0.108030897
## 3     trail b ratio -0.03119767 -0.07934039  0.016945049
## 4     trail a ratio -0.05348831 -0.10019206 -0.006784559
## 5            ds fwd -0.06562414 -0.10448984 -0.026758445
## 6            ds bwd -0.07704149 -0.11933512 -0.034747874
## 7              mint -0.19568211 -0.24477494 -0.146589289
## 8           animals -0.19270441 -0.24220874 -0.143200076
## 9               veg -0.16781840 -0.21429088 -0.121345922
## 10        words (f) -0.09410617 -0.13870478 -0.049507574
## 11        words (l) -0.10293648 -0.14712789 -0.058745067
## 12      benson copy -0.01847762 -0.05718611  0.020230874
## 13    benson recall -0.21838630 -0.26218791 -0.174584687
## 14     craft immed. -0.22093423 -0.26321244 -0.178656015
## 15      craft delay -0.22407789 -0.26725588 -0.180899908
##    sboc_behav_total    Estimate      CI.low     CI.high
## 1              moca -0.32097206 -0.37567969 -0.26626442
## 2  uds-ef composite -0.16175750 -0.21680932 -0.10670569
## 3     trail b ratio -0.03714485 -0.08744258  0.01315289
## 4     trail a ratio -0.08352625 -0.13376152 -0.03329099
## 5            ds fwd -0.07370237 -0.11431328 -0.03309145
## 6            ds bwd -0.05797410 -0.10183472 -0.01411348
## 7              mint -0.27664791 -0.32741214 -0.22588367
## 8           animals -0.19373406 -0.24532492 -0.14214319
## 9               veg -0.19577224 -0.24420130 -0.14734317
## 10        words (f) -0.09642285 -0.14340234 -0.04944335
## 11        words (l) -0.09248909 -0.13900122 -0.04597695
## 12      benson copy  0.02824425 -0.01203820  0.06852669
## 13    benson recall -0.25130583 -0.29679900 -0.20581266
## 14     craft immed. -0.24688580 -0.29109730 -0.20267430
## 15      craft delay -0.25786153 -0.30297415 -0.21274891
##             iri_emp     Estimate      CI.low       CI.high
## 1              moca -0.110657380 -0.16758170 -0.0537330555
## 2  uds-ef composite -0.044604122 -0.10092875  0.0117205112
## 3     trail b ratio -0.040190611 -0.09309253  0.0127113043
## 4     trail a ratio -0.054111260 -0.10918413  0.0009616106
## 5            ds fwd -0.018127935 -0.06008170  0.0238258261
## 6            ds bwd -0.021026367 -0.06708148  0.0250287476
## 7              mint -0.045778733 -0.09519860  0.0036411360
## 8           animals -0.091963448 -0.14610993 -0.0378169676
## 9               veg -0.068884266 -0.11997169 -0.0177968377
## 10        words (f) -0.004116312 -0.05244557  0.0442129423
## 11        words (l) -0.011089544 -0.05961348  0.0374343936
## 12      benson copy -0.116888536 -0.15708051 -0.0766965599
## 13    benson recall -0.087526928 -0.13530962 -0.0397442350
## 14     craft immed. -0.054126717 -0.10048027 -0.0077731647
## 15      craft delay -0.047894141 -0.09588832  0.0001000398
##              iri_pt      Estimate       CI.low      CI.high
## 1              moca -0.0473369438 -0.104522439  0.009848551
## 2  uds-ef composite  0.0087815151 -0.047566409  0.065129440
## 3     trail b ratio -0.0208568226 -0.073451612  0.031737966
## 4     trail a ratio -0.0007638558 -0.056850834  0.055323123
## 5            ds fwd -0.0151822600 -0.056997315  0.026632795
## 6            ds bwd -0.0233787864 -0.068924297  0.022166724
## 7              mint  0.0396053124 -0.008193271  0.087403896
## 8           animals -0.0328841768 -0.086766291  0.020997937
## 9               veg  0.0077421212 -0.043255746  0.058739989
## 10        words (f)  0.0088773532 -0.039450628  0.057205334
## 11        words (l)  0.0088195613 -0.039337921  0.056977043
## 12      benson copy -0.1283261962 -0.168609727 -0.088042665
## 13    benson recall -0.0491958352 -0.097239852 -0.001151818
## 14     craft immed.  0.0449757772 -0.001186608  0.091138162
## 15      craft delay  0.0357776703 -0.011992242  0.083547583
##            rsms_sen     Estimate      CI.low      CI.high
## 1              moca -0.047245190 -0.09728935  0.002798969
## 2  uds-ef composite  0.005713362 -0.04389590  0.055322627
## 3     trail b ratio -0.037085108 -0.08255952  0.008389299
## 4     trail a ratio -0.023923415 -0.07123174  0.023384909
## 5            ds fwd -0.011566160 -0.04858897  0.025456652
## 6            ds bwd -0.029339936 -0.06982229  0.011142417
## 7              mint  0.087656193  0.04404320  0.131269186
## 8           animals  0.008652195 -0.03888358  0.056187966
## 9               veg  0.015078460 -0.02968048  0.059837401
## 10        words (f) -0.003865272 -0.04624289  0.038512346
## 11        words (l)  0.003613030 -0.03865049  0.045876552
## 12      benson copy -0.150623508 -0.18564879 -0.115598230
## 13    benson recall -0.025314594 -0.06707227  0.016443087
## 14     craft immed.  0.017022112 -0.02378652  0.057830742
## 15      craft delay  0.019611668 -0.02233970  0.061563041
##        rsms_selfpre      Estimate       CI.low     CI.high
## 1              moca -0.0084331610 -0.060996237  0.04412992
## 2  uds-ef composite  0.1149315162  0.063980287  0.16588275
## 3     trail b ratio  0.0554730104  0.007852489  0.10309353
## 4     trail a ratio  0.0415606351 -0.007990405  0.09111168
## 5            ds fwd  0.0341233535 -0.004199729  0.07244644
## 6            ds bwd  0.0362571057 -0.005636553  0.07815076
## 7              mint  0.0333983698 -0.011752388  0.07854913
## 8           animals  0.0696187521  0.020415021  0.11882248
## 9               veg  0.0599455165  0.013907464  0.10598357
## 10        words (f)  0.0702001777  0.026582197  0.11381816
## 11        words (l)  0.0938570952  0.050170696  0.13754349
## 12      benson copy -0.0954155213 -0.132334399 -0.05849664
## 13    benson recall -0.0001828693 -0.043548414  0.04318268
## 14     craft immed.  0.0489607444  0.006669069  0.09125242
## 15      craft delay  0.0547385616  0.011376141  0.09810098
##          rsms_total     Estimate       CI.low     CI.high
## 1              moca -0.032370527 -0.082477132  0.01773608
## 2  uds-ef composite  0.060091450  0.011173949  0.10900895
## 3     trail b ratio  0.006456274 -0.038723566  0.05163611
## 4     trail a ratio  0.001963461 -0.044979193  0.04890612
## 5            ds fwd  0.012436065 -0.024259314  0.04913145
## 6            ds bwd  0.003304911 -0.036789537  0.04339936
## 7              mint  0.062254447  0.019015031  0.10549386
## 8           animals  0.041218360 -0.005887952  0.08832467
## 9               veg  0.036020316 -0.008164354  0.08020499
## 10        words (f)  0.032217659 -0.009624656  0.07405997
## 11        words (l)  0.049608021  0.007858323  0.09135772
## 12      benson copy -0.129917592 -0.164951907 -0.09488328
## 13    benson recall -0.012151499 -0.053542330  0.02923933
## 14     craft immed.  0.033142882 -0.007268527  0.07355429
## 15      craft delay  0.037291873 -0.004103526  0.07868727
##         frontal_roi    Estimate       CI.low    CI.high
## 1              moca  0.19668282  0.090060931 0.30330471
## 2  uds-ef composite  0.16987382  0.063623406 0.27612424
## 3     trail b ratio  0.09951573  0.016790785 0.18224067
## 4     trail a ratio  0.09838669  0.013105717 0.18366767
## 5            ds fwd  0.06524392 -0.010109300 0.14059714
## 6            ds bwd  0.10334756  0.026779583 0.17991554
## 7              mint -0.06096415 -0.162704997 0.04077669
## 8           animals  0.04890314 -0.045724858 0.14353113
## 9               veg  0.07783731 -0.007980248 0.16365486
## 10        words (f)  0.10149943  0.014663908 0.18833495
## 11        words (l)  0.08460334 -0.002466617 0.17167330
## 12      benson copy  0.12279833  0.042496408 0.20310026
## 13    benson recall  0.10706750  0.016803341 0.19733165
## 14     craft immed.  0.13505864  0.046364429 0.22375285
## 15      craft delay  0.18385936  0.095813168 0.27190556
##        parietal_roi    Estimate      CI.low    CI.high
## 1              moca  0.20293229  0.09818474 0.30767984
## 2  uds-ef composite  0.16623672  0.06170933 0.27076412
## 3     trail b ratio  0.12391464  0.04304194 0.20478734
## 4     trail a ratio  0.05909026 -0.02088647 0.13906699
## 5            ds fwd  0.05372649 -0.02048824 0.12794122
## 6            ds bwd  0.12273829  0.04778142 0.19769516
## 7              mint -0.01604564 -0.11486185 0.08277057
## 8           animals  0.03861059 -0.05285667 0.13007786
## 9               veg  0.12621751  0.04248561 0.20994941
## 10        words (f)  0.06681243 -0.01896804 0.15259289
## 11        words (l)  0.07459311 -0.01114250 0.16032872
## 12      benson copy  0.20291109  0.12627257 0.27954960
## 13    benson recall  0.11811268  0.02994976 0.20627560
## 14     craft immed.  0.08019911 -0.00752618 0.16792440
## 15      craft delay  0.11334948  0.02569559 0.20100338
##        temporal_roi    Estimate        CI.low    CI.high
## 1              moca 0.278918865  0.1838356904 0.37400204
## 2  uds-ef composite 0.133881523  0.0359907701 0.23177228
## 3     trail b ratio 0.031406423 -0.0458628131 0.10867566
## 4     trail a ratio 0.039729341 -0.0406589116 0.12011759
## 5            ds fwd 0.010532291 -0.0589138200 0.07997840
## 6            ds bwd 0.009562946 -0.0614301899 0.08055608
## 7              mint 0.323575292  0.2380987287 0.40905186
## 8           animals 0.134337688  0.0493672761 0.21930810
## 9               veg 0.196145851  0.1198291459 0.27246256
## 10        words (f) 0.051231244 -0.0288992954 0.13136178
## 11        words (l) 0.064792182 -0.0152528172 0.14483718
## 12      benson copy 0.074488700  0.0002367551 0.14874064
## 13    benson recall 0.228821577  0.1489739461 0.30866921
## 14     craft immed. 0.119185666  0.0377399123 0.20063142
## 15      craft delay 0.169860309  0.0891178786 0.25060274
##       occipital_roi    Estimate       CI.low    CI.high
## 1              moca  0.16756119  0.056923509 0.27819887
## 2  uds-ef composite  0.17008111  0.060445031 0.27971720
## 3     trail b ratio  0.08973559  0.003737106 0.17573408
## 4     trail a ratio  0.08033236 -0.005991461 0.16665618
## 5            ds fwd  0.07570245 -0.001899206 0.15330410
## 6            ds bwd  0.12216913  0.043484538 0.20085373
## 7              mint -0.02568151 -0.129917374 0.07855435
## 8           animals  0.02005817 -0.077218598 0.11733493
## 9               veg  0.09254430  0.004202136 0.18088646
## 10        words (f)  0.10267514  0.013120760 0.19222952
## 11        words (l)  0.09585961  0.006189728 0.18552949
## 12      benson copy  0.13286165  0.050466390 0.21525690
## 13    benson recall  0.08757240 -0.005451848 0.18059665
## 14     craft immed.  0.10380927  0.011981091 0.19563745
## 15      craft delay  0.11610606  0.024082144 0.20812999
##       nfl3_mean_log    Estimate      CI.low      CI.high
## 1              moca -0.20504498 -0.26560225 -0.144487708
## 2  uds-ef composite -0.37910222 -0.43437512 -0.323829332
## 3     trail b ratio -0.20686145 -0.25738251 -0.156340390
## 4     trail a ratio -0.19823716 -0.25074063 -0.145733681
## 5            ds fwd -0.10049679 -0.14461091 -0.056382670
## 6            ds bwd -0.15939027 -0.20550293 -0.113277601
## 7              mint -0.13461911 -0.19144525 -0.077792970
## 8           animals -0.29956943 -0.35349015 -0.245648700
## 9               veg -0.22742706 -0.27895809 -0.175896033
## 10        words (f) -0.24215226 -0.29010485 -0.194199675
## 11        words (l) -0.27916909 -0.32641200 -0.231926187
## 12      benson copy -0.04944736 -0.09250113 -0.006393603
## 13    benson recall -0.06774707 -0.11819820 -0.017295942
## 14     craft immed. -0.11995189 -0.16886572 -0.071038050
## 15      craft delay -0.11446377 -0.16481554 -0.064112011

UDS early detection

## [1]  379 1832
## 
##         C9 C9 and GRN        GRN       MAPT       none 
##         79          2         46         33        219 
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
##            c9vsnone    Estimate     CI.low     CI.high
## 1              moca -0.12149082 -0.3787379  0.13575625
## 2  uds-ef composite -0.18493216 -0.4306005  0.06073616
## 3     trail b ratio -0.23511479 -0.4810810  0.01085142
## 4     trail a ratio -0.22154406 -0.4636075  0.02051942
## 5            ds fwd -0.02394200 -0.2871070  0.23922295
## 6            ds bwd -0.05598279 -0.3162760  0.20431041
## 7              mint -0.14719408 -0.4257722  0.13138401
## 8           animals -0.29309872 -0.5500772 -0.03612028
## 9               veg -0.30366782 -0.5695066 -0.03782901
## 10        words (f) -0.05665932 -0.3101677  0.19684905
## 11        words (l)  0.01639177 -0.2476744  0.28045794
## 12      benson copy -0.32701316 -0.5993875 -0.05463878
## 13    benson recall -0.25178057 -0.5194882  0.01592709
## 14     craft immed. -0.09001340 -0.3649260  0.18489919
## 15      craft delay -0.16655184 -0.4406703  0.10756660
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
##           grnvsnone      Estimate      CI.low    CI.high
## 1              moca -0.0407583294 -0.36113377 0.27961712
## 2  uds-ef composite -0.0283538998 -0.34200125 0.28529345
## 3     trail b ratio -0.0580367089 -0.35918929 0.24311588
## 4     trail a ratio -0.2178996722 -0.51642385 0.08062451
## 5            ds fwd -0.1432076663 -0.46270361 0.17628828
## 6            ds bwd  0.0303165438 -0.28922098 0.34985406
## 7              mint -0.0191970620 -0.37985720 0.34146308
## 8           animals -0.1000092374 -0.42918163 0.22916315
## 9               veg  0.1924169878 -0.13089648 0.51573045
## 10        words (f)  0.2963340217 -0.03099102 0.62365906
## 11        words (l) -0.0008569346 -0.32438158 0.32266771
## 12      benson copy -0.0810869070 -0.40590621 0.24373240
## 13    benson recall -0.1408965569 -0.47149158 0.18969847
## 14     craft immed. -0.2450830803 -0.56880937 0.07864321
## 15      craft delay -0.1592486554 -0.48395514 0.16545783
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
## [1] "In progress, does not work yet"
##          maptvsnone      Estimate      CI.low    CI.high
## 1              moca -0.0407583294 -0.36113377 0.27961712
## 2  uds-ef composite -0.0283538998 -0.34200125 0.28529345
## 3     trail b ratio -0.0580367089 -0.35918929 0.24311588
## 4     trail a ratio -0.2178996722 -0.51642385 0.08062451
## 5            ds fwd -0.1432076663 -0.46270361 0.17628828
## 6            ds bwd  0.0303165438 -0.28922098 0.34985406
## 7              mint -0.0191970620 -0.37985720 0.34146308
## 8           animals -0.1000092374 -0.42918163 0.22916315
## 9               veg  0.1924169878 -0.13089648 0.51573045
## 10        words (f)  0.2963340217 -0.03099102 0.62365906
## 11        words (l) -0.0008569346 -0.32438158 0.32266771
## 12      benson copy -0.0810869070 -0.40590621 0.24373240
## 13    benson recall -0.1408965569 -0.47149158 0.18969847
## 14     craft immed. -0.2450830803 -0.56880937 0.07864321
## 15      craft delay -0.1592486554 -0.48395514 0.16545783
## 
##   0   1 
##   9 160 
## 
##  Descriptive statistics by group 
## group: 0
##    vars n  mean  sd median trimmed  mad   min max range skew kurtosis   se
## X1    1 7 -0.37 1.1  -0.57   -0.37 0.61 -1.93 1.2  3.13 0.21    -1.51 0.41
## ------------------------------------------------------------ 
## group: 1
##    vars   n mean   sd median trimmed  mad   min  max range  skew kurtosis   se
## X1    1 154 0.12 0.75   0.11    0.13 0.79 -1.89 2.13  4.02 -0.11     0.14 0.06
##      mut_vs_famcont    Estimate      CI.low     CI.high
## 1              moca -0.04425983 -0.16848983  0.07997017
## 2  uds-ef composite  0.08862596 -0.06098143  0.23823335
## 3     trail b ratio -0.01144449 -0.16716256  0.14427358
## 4     trail a ratio  0.04074652 -0.09759640  0.17908945
## 5            ds fwd  0.08910548 -0.05763383  0.23584480
## 6            ds bwd  0.10641248 -0.03568258  0.24850753
## 7              mint -0.02699277 -0.17423145  0.12024590
## 8           animals -0.04142803 -0.20052178  0.11766572
## 9               veg  0.04036607 -0.12328160  0.20401374
## 10        words (f)  0.07676849 -0.05698396  0.21052093
## 11        words (l)  0.01431016 -0.12786207  0.15648239
## 12      benson copy -0.01118691 -0.14823786  0.12586404
## 13    benson recall -0.09403601 -0.23625133  0.04817930
## 14     craft immed. -0.06060082 -0.20209390  0.08089225
## 15      craft delay -0.16843922 -0.30846691 -0.02841153

UDS power analysis

UDS power analysis: CDR>0, mut+

## 
## Attaching package: 'effectsize'
## The following object is masked from 'package:psych':
## 
##     phi

## 
##   C9  GRN MAPT 
##   72   34   39
list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.4719884 -1.6914795 0.7475028 1677 655
uds3_ef_v2 uds3_ef_diff -0.4910308 -1.6685969 0.6865353 1445 565
traila_ratio_v2 traila_ratio_diff -0.2335328 -1.1505186 0.6834530 3873 1513
trailb_ratio_v2 trailb_ratio_diff -0.3265544 -1.4304760 0.7773672 2871 1122
dig_fwd_sum_v2 dig_fwd_sum_diff -0.1961206 -1.0939729 0.7017317 5265 2057
dig_back_sum_v2 dig_back_sum_diff -0.2707438 -1.2454840 0.7039965 3256 1272
mint_total_v2 mint_total_diff -0.2708433 -1.4671930 0.9255065 4901 1915
flu_animal_v2 flu_animal_diff -0.3933764 -1.2684914 0.4817386 1243 486
flu_veg_v2 flu_veg_diff -0.2172052 -1.1920962 0.7576858 5060 1977
flu_fwords_v2 flu_fwords_diff -0.1702049 -0.9451926 0.6047827 5208 2035
flu_lwords_v2 flu_lwords_diff -0.1419364 -1.0509121 0.7670392 10301 4024
benson_copy_v2 benson_copy_diff -0.1760947 -1.3686512 1.0164618 11520 4500
benson_delay_v2 benson_delay_diff -0.1074311 -1.1397297 0.9248675 23191 9059
craft_v_immed_v2 craft_v_immed_diff -0.3589964 -1.3210150 0.6030222 1804 705
craft_v_delay_v2 craft_v_delay_diff -0.3530198 -1.3415580 0.6355184 1970 770

UDS power analysis: CDR > 0, MAPT

## 
## MAPT 
##   35
list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.4968000 -1.4327150 0.4391150 892 349
uds3_ef_v2 uds3_ef_diff -0.5200204 -1.5224484 0.4824076 934 365
traila_ratio_v2 traila_ratio_diff -0.2080911 -0.9665810 0.5503989 3337 1304
trailb_ratio_v2 trailb_ratio_diff -0.4218631 -1.5971252 0.7533991 1950 762
dig_fwd_sum_v2 dig_fwd_sum_diff -0.0134996 -0.8157054 0.7887063 886930 346457
dig_back_sum_v2 dig_back_sum_diff -0.1802572 -1.1779921 0.8174776 7695 3006
mint_total_v2 mint_total_diff -0.4247707 -1.9543914 1.1048499 3257 1273
flu_animal_v2 flu_animal_diff -0.4032241 -1.0143466 0.2078984 577 226
flu_veg_v2 flu_veg_diff -0.2487125 -1.0953173 0.5978922 2911 1137
flu_fwords_v2 flu_fwords_diff -0.0242767 -0.7205112 0.6719577 206580 80695
flu_lwords_v2 flu_lwords_diff -0.4379637 -0.9983888 0.1224614 412 161
benson_copy_v2 benson_copy_diff -0.2546396 -1.6055362 1.0962570 7069 2762
benson_delay_v2 benson_delay_diff -0.0172799 -1.0472345 1.0126748 892304 348557
craft_v_immed_v2 craft_v_immed_diff -0.1813338 -1.0082871 0.6456196 5224 2041
craft_v_delay_v2 craft_v_delay_diff -0.2484221 -1.0929364 0.5960923 2903 1134

UDS power analysis: CDR > 0, C9

## 
## C9 
## 67
list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.3440581 -1.6095936 0.9214774 3399 1328
uds3_ef_v2 uds3_ef_diff -0.3529413 -1.3772654 0.6713827 2116 827
traila_ratio_v2 traila_ratio_diff -0.0827587 -0.8718167 0.7062993 22833 8919
trailb_ratio_v2 trailb_ratio_diff -0.1944537 -1.0000445 0.6111372 4311 1684
dig_fwd_sum_v2 dig_fwd_sum_diff -0.2758813 -1.0811106 0.5293481 2140 836
dig_back_sum_v2 dig_back_sum_diff -0.2876689 -1.1986613 0.6233235 2519 984
mint_total_v2 mint_total_diff -0.1241590 -1.1449749 0.8966569 16979 6633
flu_animal_v2 flu_animal_diff -0.3640973 -1.3148244 0.5866299 1713 669
flu_veg_v2 flu_veg_diff -0.1224789 -1.1170426 0.8720847 16562 6470
flu_fwords_v2 flu_fwords_diff -0.2283597 -0.8775271 0.4208077 2030 793
flu_lwords_v2 flu_lwords_diff -0.0101199 -0.9899077 0.9696680 2354354 919670
benson_copy_v2 benson_copy_diff -0.0631214 -0.8512754 0.7250327 39159 15297
benson_delay_v2 benson_delay_diff -0.0483813 -0.9810217 0.8842591 93332 36458
craft_v_immed_v2 craft_v_immed_diff -0.3461550 -1.2779815 0.5856715 1821 711
craft_v_delay_v2 craft_v_delay_diff -0.3860862 -1.4308304 0.6586581 1840 719

UDS power analysis: CDR > 0, GRN

## 
## GRN 
##  34
list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.8362763 -2.259870 0.5873172 728 285
uds3_ef_v2 uds3_ef_diff -1.0448722 -2.808068 0.7183233 716 280
traila_ratio_v2 traila_ratio_diff -0.9632880 -2.168967 0.2423912 394 154
trailb_ratio_v2 trailb_ratio_diff -0.7986341 -2.649834 1.0525661 1350 528
dig_fwd_sum_v2 dig_fwd_sum_diff -0.4871035 -1.687541 0.7133337 1526 596
dig_back_sum_v2 dig_back_sum_diff -0.3545088 -1.519938 0.8109202 2715 1061
mint_total_v2 mint_total_diff -0.7473087 -1.528450 0.0338324 275 108
flu_animal_v2 flu_animal_diff -0.4437048 -1.475971 0.5885609 1360 531
flu_veg_v2 flu_veg_diff -0.4540616 -1.594120 0.6859964 1584 619
flu_fwords_v2 flu_fwords_diff -0.3951392 -1.541259 0.7509809 2114 826
flu_lwords_v2 flu_lwords_diff -0.1942760 -1.300014 0.9114618 8137 3179
benson_copy_v2 benson_copy_diff -0.5490034 -2.410815 1.3128084 2889 1129
benson_delay_v2 benson_delay_diff -0.4235651 -1.654440 0.8073092 2121 829
craft_v_immed_v2 craft_v_immed_diff -0.7860111 -1.747081 0.1750590 376 147
craft_v_delay_v2 craft_v_delay_diff -0.5896426 -1.600097 0.4208118 738 289

UDS power analysis syndrome subsets

UDS power analysis syndrome subsets: description

ad als bvftd cbs cu dementia with lewy bodies lvppa mci nvppa other pd psp svppa p test ad als bvftd cbs cu dementia with lewy bodies lvppa mci nvppa other pd psp svppa p test
n 5 10 218 26 484 1 6 65 38 22 3 16 48 5 10 218 26 484 1 6 65 38 22 3 16 48
sex = Male (%) 1 (20.0) 8 (80.0) 133 (61.0) 14 (53.8) 189 ( 39.0) 1 (100.0) 2 (33.3) 31 ( 47.7) 16 (42.1) 10 (45.5) 2 ( 66.7) 10 ( 62.5) 28 ( 58.3) <0.001 1 (20.0) 8 (80.0) 133 (61.0) 14 (53.8) 189 ( 39.0) 1 (100.0) 2 (33.3) 31 ( 47.7) 16 (42.1) 10 (45.5) 2 ( 66.7) 10 ( 62.5) 28 ( 58.3) <0.001
ftldcdr_glob (%) <0.001 <0.001
0 0 ( 0.0) 1 (10.0) 0 ( 0.0) 1 ( 3.8) 484 (100.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 13 (59.1) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 1 (10.0) 0 ( 0.0) 1 ( 3.8) 484 (100.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 13 (59.1) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0)
0.5 1 (20.0) 2 (20.0) 26 (11.9) 9 (34.6) 0 ( 0.0) 0 ( 0.0) 2 (33.3) 65 (100.0) 15 (39.5) 7 (31.8) 3 (100.0) 6 ( 37.5) 14 ( 29.2) 1 (20.0) 2 (20.0) 26 (11.9) 9 (34.6) 0 ( 0.0) 0 ( 0.0) 2 (33.3) 65 (100.0) 15 (39.5) 7 (31.8) 3 (100.0) 6 ( 37.5) 14 ( 29.2)
1 2 (40.0) 4 (40.0) 90 (41.3) 10 (38.5) 0 ( 0.0) 0 ( 0.0) 3 (50.0) 0 ( 0.0) 19 (50.0) 0 ( 0.0) 0 ( 0.0) 8 ( 50.0) 24 ( 50.0) 2 (40.0) 4 (40.0) 90 (41.3) 10 (38.5) 0 ( 0.0) 0 ( 0.0) 3 (50.0) 0 ( 0.0) 19 (50.0) 0 ( 0.0) 0 ( 0.0) 8 ( 50.0) 24 ( 50.0)
2 2 (40.0) 3 (30.0) 89 (40.8) 5 (19.2) 0 ( 0.0) 1 (100.0) 1 (16.7) 0 ( 0.0) 3 ( 7.9) 1 ( 4.5) 0 ( 0.0) 1 ( 6.2) 10 ( 20.8) 2 (40.0) 3 (30.0) 89 (40.8) 5 (19.2) 0 ( 0.0) 1 (100.0) 1 (16.7) 0 ( 0.0) 3 ( 7.9) 1 ( 4.5) 0 ( 0.0) 1 ( 6.2) 10 ( 20.8)
3 0 ( 0.0) 0 ( 0.0) 13 ( 6.0) 1 ( 3.8) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 1 ( 2.6) 1 ( 4.5) 0 ( 0.0) 1 ( 6.2) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 13 ( 6.0) 1 ( 3.8) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 1 ( 2.6) 1 ( 4.5) 0 ( 0.0) 1 ( 6.2) 0 ( 0.0)
genetic_factor (%) <0.001 <0.001
C9 0 ( 0.0) 6 (75.0) 45 (22.6) 0 ( 0.0) 108 ( 24.1) 0 ( 0.0) 0 ( 0.0) 17 ( 27.9) 2 ( 6.5) 7 (38.9) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 6 (75.0) 45 (22.6) 0 ( 0.0) 108 ( 24.1) 0 ( 0.0) 0 ( 0.0) 17 ( 27.9) 2 ( 6.5) 7 (38.9) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0)
C9 and GRN 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 3 ( 0.7) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 3 ( 0.7) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0)
GRN 2 (50.0) 0 ( 0.0) 14 ( 7.0) 5 (19.2) 52 ( 11.6) 0 ( 0.0) 2 (40.0) 7 ( 11.5) 3 ( 9.7) 4 (22.2) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 2 (50.0) 0 ( 0.0) 14 ( 7.0) 5 (19.2) 52 ( 11.6) 0 ( 0.0) 2 (40.0) 7 ( 11.5) 3 ( 9.7) 4 (22.2) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0)
MAPT 2 (50.0) 0 ( 0.0) 26 (13.1) 1 ( 3.8) 56 ( 12.5) 0 ( 0.0) 0 ( 0.0) 8 ( 13.1) 0 ( 0.0) 2 (11.1) 2 ( 66.7) 0 ( 0.0) 0 ( 0.0) 2 (50.0) 0 ( 0.0) 26 (13.1) 1 ( 3.8) 56 ( 12.5) 0 ( 0.0) 0 ( 0.0) 8 ( 13.1) 0 ( 0.0) 2 (11.1) 2 ( 66.7) 0 ( 0.0) 0 ( 0.0)
none 0 ( 0.0) 2 (25.0) 114 (57.3) 20 (76.9) 229 ( 51.1) 1 (100.0) 3 (60.0) 29 ( 47.5) 26 (83.9) 5 (27.8) 1 ( 33.3) 13 (100.0) 42 (100.0) 0 ( 0.0) 2 (25.0) 114 (57.3) 20 (76.9) 229 ( 51.1) 1 (100.0) 3 (60.0) 29 ( 47.5) 26 (83.9) 5 (27.8) 1 ( 33.3) 13 (100.0) 42 (100.0)
Overall ad als bvftd cbs cu dementia with lewy bodies lvppa mci nvppa other pd psp svppa p test
n 971 5 10 218 26 484 1 6 65 38 22 3 16 48
moca_total (mean (SD)) 24.04 (6.06) 21.80 (3.96) 22.90 (3.63) 19.17 (6.88) 17.81 (6.83) 27.31 (2.29) 20.00 (NA) 13.40 (7.77) 25.42 (3.13) 20.71 (6.19) 26.56 (4.71) 23.33 (2.08) 20.64 (5.90) 15.87 (6.67) NA
uds3_ef (mean (SD)) -0.63 (1.34) -1.12 (1.18) -1.71 (0.87) -1.79 (1.20) -2.14 (1.19) 0.21 (0.73) -1.61 (NA) -1.79 (0.96) -0.52 (0.83) -1.98 (0.89) 0.09 (1.06) -1.32 (0.97) -2.58 (1.15) -2.03 (0.90) NA
traila_ratio (mean (SD)) 0.92 (0.42) 0.79 (0.20) 0.44 (0.20) 0.61 (0.29) 0.45 (0.26) 1.13 (0.36) 0.51 (NA) 0.60 (0.18) 0.89 (0.31) 0.58 (0.25) 1.09 (0.45) 0.55 (0.36) 0.35 (0.19) 0.65 (0.31) NA
trailb_ratio (mean (SD)) 0.38 (0.19) 0.22 (0.16) 0.18 (0.13) 0.24 (0.14) 0.15 (0.14) 0.48 (0.16) 0.20 (NA) 0.15 (0.08) 0.35 (0.14) 0.20 (0.10) 0.42 (0.17) 0.27 (0.12) 0.14 (0.11) 0.24 (0.13) NA
dig_fwd_sum (mean (SD)) 8.05 (2.66) 8.75 (2.22) 6.60 (1.78) 6.85 (2.55) 5.68 (2.36) 8.96 (2.33) 7.00 (NA) 4.75 (2.22) 8.31 (2.18) 4.88 (2.24) 9.44 (2.64) 8.33 (1.53) 7.14 (2.80) 6.93 (2.58) NA
dig_back_sum (mean (SD)) 6.59 (2.80) 7.25 (2.06) 5.40 (1.43) 4.85 (2.66) 3.82 (2.40) 7.76 (2.30) 4.00 (NA) 3.25 (1.50) 6.71 (2.26) 4.09 (2.18) 8.17 (2.01) 5.33 (2.31) 3.50 (2.71) 5.64 (2.84) NA
mint_total (mean (SD)) 24.89 (7.67) 14.50 (10.61) 24.00 (6.08) 23.44 (7.69) 23.11 (8.56) 28.50 (1.57) 29.00 (NA) 22.00 (10.23) 26.67 (3.41) 25.18 (6.59) 25.78 (9.05) 28.00 (2.00) 26.56 (4.50) 7.98 (8.42) NA
flu_animal (mean (SD)) 19.24 (8.18) 17.60 (11.84) 14.70 (5.23) 13.43 (7.39) 11.86 (7.66) 23.57 (5.60) 17.00 (NA) 15.50 (5.92) 20.40 (6.61) 12.03 (5.79) 22.00 (7.77) 18.00 (5.29) 11.57 (5.80) 8.02 (5.23) NA
flu_veg (mean (SD)) 12.26 (5.80) 11.25 (8.10) 8.67 (4.00) 7.97 (5.16) 7.91 (5.85) 15.31 (4.17) 6.00 (NA) 9.00 (2.58) 12.58 (3.63) 8.40 (4.43) 14.78 (4.89) 10.33 (5.51) 7.50 (4.50) 4.07 (4.24) NA
flu_fwords (mean (SD)) 12.37 (5.90) 9.60 (3.85) 9.70 (3.59) 8.34 (5.27) 7.64 (4.91) 15.23 (4.72) 6.00 (NA) 9.25 (3.77) 12.97 (4.04) 6.63 (4.00) 15.56 (4.73) 8.67 (6.03) 4.86 (4.87) 7.33 (4.68) NA
flu_lwords (mean (SD)) 11.69 (5.61) 12.60 (6.35) 8.50 (3.60) 7.71 (5.10) 7.55 (5.47) 14.33 (4.44) 8.00 (NA) 9.25 (5.19) 12.00 (3.88) 6.48 (3.95) 15.28 (4.85) 9.33 (5.86) 5.86 (4.74) 7.10 (4.51) NA
benson_copy (mean (SD)) 15.07 (2.41) 16.60 (0.55) 13.30 (3.40) 14.47 (2.88) 11.11 (5.70) 15.64 (1.27) 15.00 (NA) 13.00 (6.06) 15.27 (1.46) 14.00 (4.11) 16.06 (1.30) 14.67 (0.58) 11.00 (3.96) 15.00 (1.96) NA
benson_delay (mean (SD)) 10.81 (4.24) 6.40 (4.04) 9.44 (4.07) 7.70 (4.72) 7.00 (4.68) 12.67 (2.59) 12.00 (NA) 6.75 (4.57) 10.97 (3.34) 10.31 (4.64) 13.61 (2.35) 10.67 (3.21) 7.86 (3.68) 6.78 (5.17) NA
craft_v_immed (mean (SD)) 18.81 (8.74) 15.00 (8.41) 16.70 (8.73) 13.38 (8.36) 14.10 (8.62) 22.64 (6.56) 22.00 (NA) 8.00 (2.16) 20.92 (7.24) 13.61 (8.30) 20.67 (8.25) 11.33 (4.04) 15.93 (8.39) 6.93 (6.83) NA
craft_v_delay (mean (SD)) 16.28 (8.81) 10.75 (9.36) 14.44 (7.50) 9.66 (7.75) 12.05 (9.28) 20.44 (6.69) 18.00 (NA) 8.75 (4.99) 17.82 (7.94) 11.10 (7.63) 18.72 (7.75) 8.00 (2.65) 13.64 (7.59) 5.91 (6.81) NA

UDS power analysis syndrome subsets: df.cu

list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff 0.2883779 -0.2508437 0.8275995 879 343
uds3_ef_v2 uds3_ef_diff 0.2164030 -0.4871537 0.9199597 2655 1037
traila_ratio_v2 traila_ratio_diff 0.0734920 -0.8387163 0.9857003 38696 15116
trailb_ratio_v2 trailb_ratio_diff 0.0583094 -0.8512016 0.9678203 61108 23871
dig_fwd_sum_v2 dig_fwd_sum_diff 0.0950456 -0.7580742 0.9481653 20236 7905
dig_back_sum_v2 dig_back_sum_diff 0.1451184 -0.6895806 0.9798173 8310 3246
mint_total_v2 mint_total_diff 0.3909008 0.0148666 0.7669350 233 91
flu_animal_v2 flu_animal_diff 0.1644715 -0.6762394 1.0051824 6563 2564
flu_veg_v2 flu_veg_diff 0.1207781 -0.6400660 0.8816223 9968 3894
flu_fwords_v2 flu_fwords_diff 0.1706189 -0.7581930 1.0994307 7444 2908
flu_lwords_v2 flu_lwords_diff 0.1302636 -0.7856119 1.0461390 12417 4850
benson_copy_v2 benson_copy_diff 0.1525644 -0.3602405 0.6653694 2838 1109
benson_delay_v2 benson_delay_diff 0.1473818 -0.5670022 0.8617659 5902 2306
craft_v_immed_v2 craft_v_immed_diff 0.1632511 -0.6667673 0.9932694 6493 2537
craft_v_delay_v2 craft_v_delay_diff 0.1639067 -0.6745018 1.0023152 6572 2568

UDS power analysis syndrome subsets: bvftd

list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.5877455 -1.8008357 0.6253447 1070 418
uds3_ef_v2 uds3_ef_diff -0.4813484 -1.5573530 0.5946562 1256 491
traila_ratio_v2 traila_ratio_diff -0.2353923 -1.0196379 0.5488533 2788 1089
trailb_ratio_v2 trailb_ratio_diff -0.2776958 -1.3253426 0.7699510 3575 1397
dig_fwd_sum_v2 dig_fwd_sum_diff -0.1413663 -1.1025470 0.8198145 11612 4536
dig_back_sum_v2 dig_back_sum_diff -0.2651747 -1.2735574 0.7432080 3632 1419
mint_total_v2 mint_total_diff -0.4372580 -1.6114457 0.7369297 1812 708
flu_animal_v2 flu_animal_diff -0.3861719 -1.2311675 0.4588237 1203 470
flu_veg_v2 flu_veg_diff -0.3173842 -1.1668214 0.5320529 1800 703
flu_fwords_v2 flu_fwords_diff -0.3120649 -1.0173057 0.3931758 1283 502
flu_lwords_v2 flu_lwords_diff -0.2257801 -0.9497182 0.4981580 2583 1009
benson_copy_v2 benson_copy_diff -0.3127605 -1.6828127 1.0572918 4820 1883
benson_delay_v2 benson_delay_diff -0.3080012 -1.2954767 0.6794743 2582 1009
craft_v_immed_v2 craft_v_immed_diff -0.3803933 -1.3284737 0.5676871 1561 610
craft_v_delay_v2 craft_v_delay_diff -0.3379533 -1.3073274 0.6314207 2067 808

UDS power analysis syndrome subsets: cbs

list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.3016946 -1.4010121 0.7976229 3335 1303
uds3_ef_v2 uds3_ef_diff -0.4983573 -1.7285041 0.7317894 1531 598
traila_ratio_v2 traila_ratio_diff -0.4469539 -1.2924473 0.3985395 899 352
trailb_ratio_v2 trailb_ratio_diff -0.6543575 -1.5532922 0.2445773 474 186
dig_fwd_sum_v2 dig_fwd_sum_diff -0.0986893 -1.2271859 1.0298073 32842 12829
dig_back_sum_v2 dig_back_sum_diff -0.0889928 -0.9345612 0.7565756 22675 8858
mint_total_v2 mint_total_diff -0.2472614 -0.9539823 0.4594594 2052 802
flu_animal_v2 flu_animal_diff -0.3533723 -1.3609053 0.6541607 2042 798
flu_veg_v2 flu_veg_diff -0.2116151 -0.8354916 0.4122613 2183 853
flu_fwords_v2 flu_fwords_diff -0.4491375 -0.9633613 0.0650863 330 129
flu_lwords_v2 flu_lwords_diff -0.2148486 -0.6968773 0.2671801 1265 494
benson_copy_v2 benson_copy_diff -0.9203110 -2.7331903 0.8925683 975 381
benson_delay_v2 benson_delay_diff -0.2297654 -1.5515721 1.0920414 8313 3247
craft_v_immed_v2 craft_v_immed_diff -0.2320252 -0.8981847 0.4341344 2071 809
craft_v_delay_v2 craft_v_delay_diff -0.3760748 -1.3828794 0.6307298 1801 704

UDS power analysis syndrome subsets: mci

list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.0709142 -1.1676767 1.0258484 60079 23468
uds3_ef_v2 uds3_ef_diff 0.0800335 -0.8702978 1.0303648 35414 13834
traila_ratio_v2 traila_ratio_diff 0.0527469 -0.8215182 0.9270120 69001 26954
trailb_ratio_v2 trailb_ratio_diff 0.1227198 -0.5789103 0.8243499 8210 3207
dig_fwd_sum_v2 dig_fwd_sum_diff -0.1287794 -1.0636300 0.8060713 13236 5171
dig_back_sum_v2 dig_back_sum_diff -0.0086344 -0.8402073 0.8229385 2329656 910022
mint_total_v2 mint_total_diff 0.0897026 -0.7171728 0.8965780 20322 7939
flu_animal_v2 flu_animal_diff -0.0228421 -0.9802363 0.9345522 441232 172357
flu_veg_v2 flu_veg_diff 0.0869499 -0.5879162 0.7618159 15131 5911
flu_fwords_v2 flu_fwords_diff -0.0444454 -0.9728752 0.8839843 109598 42812
flu_lwords_v2 flu_lwords_diff 0.1136010 -0.9238013 1.1510032 20946 8182
benson_copy_v2 benson_copy_diff -0.0212167 -1.0485754 1.0061419 588904 230041
benson_delay_v2 benson_delay_diff 0.0860965 -0.8798146 1.0520075 31613 12349
craft_v_immed_v2 craft_v_immed_diff -0.0961376 -1.1264733 0.9341981 28849 11270
craft_v_delay_v2 craft_v_delay_diff -0.1295156 -1.1160080 0.8569767 14572 5692

UDS power analysis syndrome subsets: nvppa

list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.6448427 -1.8163045 0.5266191 829 324
uds3_ef_v2 uds3_ef_diff 0.0160992 -1.8695743 1.9017727 3445745 1345994
traila_ratio_v2 traila_ratio_diff -0.1868796 -0.7357554 0.3619962 2167 847
trailb_ratio_v2 trailb_ratio_diff -0.0752413 -0.9031761 0.7526936 30412 11880
dig_fwd_sum_v2 dig_fwd_sum_diff 0.1440803 -1.3421006 1.6302612 26724 10439
dig_back_sum_v2 dig_back_sum_diff -0.0849898 -1.7253930 1.5554134 93568 36550
mint_total_v2 mint_total_diff -0.4818249 -1.9891037 1.0254539 2458 961
flu_animal_v2 flu_animal_diff -0.0650003 -0.9037552 0.7737545 41822 16337
flu_veg_v2 flu_veg_diff 0.0859041 -2.0371184 2.2089265 153405 59924
flu_fwords_v2 flu_fwords_diff -0.0967868 -0.8111048 0.6175313 13681 5344
flu_lwords_v2 flu_lwords_diff -0.0608521 -0.6375715 0.5158673 22560 8813
benson_copy_v2 benson_copy_diff -0.3339722 -1.9105617 1.2426173 5598 2187
benson_delay_v2 benson_delay_diff -0.3721843 -1.4043553 0.6599866 1932 755
craft_v_immed_v2 craft_v_immed_diff -0.2379065 -1.1225516 0.6467387 3473 1357
craft_v_delay_v2 craft_v_delay_diff -0.2068934 -0.9870912 0.5733045 3572 1396

UDS power analysis syndrome subsets: psp

list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.4189415 -1.4763406 0.6384576 1600 625
uds3_ef_v2 uds3_ef_diff 0.2229590 -0.5150798 0.9609978 2753 1076
traila_ratio_v2 traila_ratio_diff -0.0315985 -0.6688984 0.6057014 102168 39910
trailb_ratio_v2 trailb_ratio_diff -0.0778584 -0.6381399 0.4824231 13007 5081
dig_fwd_sum_v2 dig_fwd_sum_diff 0.0896162 -0.7491510 0.9283834 22003 8595
dig_back_sum_v2 dig_back_sum_diff 0.0510076 -0.7224249 0.8244402 57748 22558
mint_total_v2 mint_total_diff 0.1221007 -0.6577446 0.9019460 10246 4003
flu_animal_v2 flu_animal_diff -0.0844555 -1.0150932 0.8461821 30498 11913
flu_veg_v2 flu_veg_diff -0.3614506 -0.9797755 0.2568742 735 288
flu_fwords_v2 flu_fwords_diff 0.1217411 -0.3677485 0.6112307 4061 1587
flu_lwords_v2 flu_lwords_diff -0.3569472 -0.9157617 0.2018673 616 241
benson_copy_v2 benson_copy_diff -0.2151276 -1.6937271 1.2634720 11865 4635
benson_delay_v2 benson_delay_diff -0.1422431 -1.3611072 1.0766210 18442 7204
craft_v_immed_v2 craft_v_immed_diff 0.0105321 -1.0769962 1.0980604 2677970 1046082
craft_v_delay_v2 craft_v_delay_diff 0.0467175 -0.7166354 0.8100705 67058 26195

UDS power analysis syndrome subsets: svppa

list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.5611746 -1.3941711 0.2718218 554 217
uds3_ef_v2 uds3_ef_diff -0.2190989 -1.1666428 0.7284449 4698 1835
traila_ratio_v2 traila_ratio_diff -0.3124502 -0.9466939 0.3217936 1035 405
trailb_ratio_v2 trailb_ratio_diff -0.0570931 -0.7697418 0.6555556 39133 15287
dig_fwd_sum_v2 dig_fwd_sum_diff 0.0353265 -0.8456185 0.9162715 156190 61012
dig_back_sum_v2 dig_back_sum_diff -0.4810478 -1.4495018 0.4874063 1018 398
mint_total_v2 mint_total_diff -0.2275278 -0.9656886 0.5106330 2644 1033
flu_animal_v2 flu_animal_diff -0.2764071 -0.7801430 0.2273288 835 326
flu_veg_v2 flu_veg_diff -0.1997438 -0.6668640 0.2673765 1374 537
flu_fwords_v2 flu_fwords_diff -0.1721029 -0.8951826 0.5509768 4434 1732
flu_lwords_v2 flu_lwords_diff -0.1765232 -0.8898215 0.5367751 4102 1602
benson_copy_v2 benson_copy_diff -0.0876300 -1.3163646 1.1411046 49382 19290
benson_delay_v2 benson_delay_diff -0.1228513 -1.2032681 0.9575654 19426 7589
craft_v_immed_v2 craft_v_immed_diff -0.0334459 -0.6632239 0.5963321 89053 34787
craft_v_delay_v2 craft_v_delay_diff -0.1970334 -0.8535035 0.4594367 2789 1090

UDS power analysis syndrome subsets: ad+lvppa

list.diff.uds beta.store CI.low CI.high sample_size.25 sample_size.40
moca_total_v2 moca_total_diff -0.4638726 -1.4436695 0.5159243 1121 438
uds3_ef_v2 uds3_ef_diff -0.3569858 -0.7903716 0.0764001 371 145
traila_ratio_v2 traila_ratio_diff -0.1650122 -1.1680024 0.8379779 9280 3625
trailb_ratio_v2 trailb_ratio_diff 0.1683831 0.0016148 0.3351514 247 97
dig_fwd_sum_v2 dig_fwd_sum_diff -0.4717185 -1.1262484 0.1828114 484 189
dig_back_sum_v2 dig_back_sum_diff -0.0652687 -0.4270138 0.2964764 7716 3014
mint_total_v2 mint_total_diff -1.2913414 -3.0047004 0.4220176 443 173
flu_animal_v2 flu_animal_diff -0.4458478 -1.1775807 0.2858851 677 265
flu_veg_v2 flu_veg_diff -0.6469850 -1.7839837 0.4900138 776 303
flu_fwords_v2 flu_fwords_diff -0.0551235 -0.9729119 0.8626649 69626 27198
flu_lwords_v2 flu_lwords_diff -0.2340216 -1.6331453 1.1651021 8978 3507
benson_copy_v2 benson_copy_diff -0.2981957 -1.0108229 0.4144316 1435 561
benson_delay_v2 benson_delay_diff -0.5378561 -1.1950829 0.1193706 375 147
craft_v_immed_v2 craft_v_immed_diff 0.1084594 -0.8840074 1.1009262 21031 8216
craft_v_delay_v2 craft_v_delay_diff -0.1808918 -1.2548425 0.8930589 8853 3459