2024_Eficacia analgesica meloxicam vs ibuprofeno control dolor post exodoncia

#packages

library("tidyverse")
library("Publish")

#df

#gather df2 en Hora y EVA

df2 <- df %>% 
  gather(Hora,EVA,X1.HORA:X72.HORA)

#C.I

ci.mean(df2$EVA~ df2$Medicamento*df2$Hora, data=df2)

 df2$Hora df2$Medicamento mean CI-95%     
 X1.HORA  Ibuprofeno      2.74 [1.83;3.64]
 X1.HORA  Meloxicam       3.82 [2.87;4.77]
 X2.HORA  Ibuprofeno      2.32 [1.54;3.10]
 X2.HORA  Meloxicam       3.65 [2.78;4.51]
 X24.HORA Ibuprofeno      1.15 [0.62;1.67]
 X24.HORA Meloxicam       1.44 [0.88;2.00]
 X3.HORA  Ibuprofeno      2.15 [1.42;2.87]
 X3.HORA  Meloxicam       3.26 [2.41;4.12]
 X4.HORA  Ibuprofeno      2.12 [1.42;2.81]
 X4.HORA  Meloxicam       3.09 [2.26;3.92]
 X48.HORA Ibuprofeno      1.00 [0.52;1.48]
 X48.HORA Meloxicam       1.00 [0.47;1.53]
 X5.HORA  Ibuprofeno      2.15 [1.44;2.86]
 X5.HORA  Meloxicam       2.79 [2.05;3.54]
 X6.HORA  Ibuprofeno      2.18 [1.42;2.94]
 X6.HORA  Meloxicam       2.68 [1.98;3.37]
 X7.HORA  Ibuprofeno      2.18 [1.42;2.94]
 X7.HORA  Meloxicam       2.41 [1.71;3.11]
 X72.HORA Ibuprofeno      0.62 [0.23;1.00]
 X72.HORA Meloxicam       0.47 [0.17;0.77]

#grafica

df2 %>% 
  group_by(Medicamento, Hora) %>% 
  summarise(promedio = mean(EVA), desviacion = sd(EVA))

`summarise()` has grouped output by 'Medicamento'. You can override using the `.groups` argument.

df2 %>% 
  group_by(Medicamento, Hora) %>% 
  summarise(promedio = mean(EVA), desviacion = sd(EVA)) %>% 
ggplot(aes(x = Hora, y = promedio, color = Medicamento, group = Medicamento)) +
  geom_line() +
  geom_point() +
  
  labs(x = "Hora",
       y = "Promedio EVA",
       color = "Medicamento") +
  theme_minimal()

`summarise()` has grouped output by 'Medicamento'. You can override using the `.groups` argument.

#ANOVA

summary(Repeated.Measures.ANOVA)

                          Df Sum Sq Mean Sq F value   Pr(>F)    
df2$Hora                   9  497.8   55.31  13.428  < 2e-16 ***
df2$Medicamento            1   61.8   61.80  15.005 0.000118 ***
df2$Hora:df2$Medicamento   9   39.5    4.39   1.066 0.386130    
Residuals                660 2718.4    4.12                     
---
Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1

TukeyHSD(Repeated.Measures.ANOVA)

  Tukey multiple comparisons of means
    95% family-wise confidence level

Fit: aov(formula = df2$EVA ~ df2$Hora + df2$Medicamento + df2$Hora * df2$Medicamento)

$`df2$Hora`
                         diff         lwr        upr     p adj
X2.HORA-X1.HORA   -0.29411765 -1.39905250  0.8108172 0.9978177
X24.HORA-X1.HORA  -1.98529412 -3.09022897 -0.8803593 0.0000008
X3.HORA-X1.HORA   -0.57352941 -1.67846426  0.5314054 0.8239145
X4.HORA-X1.HORA   -0.67647059 -1.78140544  0.4284643 0.6390499
X48.HORA-X1.HORA  -2.27941176 -3.38434661 -1.1744769 0.0000000
X5.HORA-X1.HORA   -0.80882353 -1.91375838  0.2961113 0.3748476
X6.HORA-X1.HORA   -0.85294118 -1.95787603  0.2519937 0.2977189
X7.HORA-X1.HORA   -0.98529412 -2.09022897  0.1196407 0.1282977
X72.HORA-X1.HORA  -2.73529412 -3.84022897 -1.6303593 0.0000000
X24.HORA-X2.HORA  -1.69117647 -2.79611132 -0.5862416 0.0000643
X3.HORA-X2.HORA   -0.27941176 -1.38434661  0.8255231 0.9985387
X4.HORA-X2.HORA   -0.38235294 -1.48728779  0.7225819 0.9848033
X48.HORA-X2.HORA  -1.98529412 -3.09022897 -0.8803593 0.0000008
X5.HORA-X2.HORA   -0.51470588 -1.61964073  0.5902290 0.9002864
X6.HORA-X2.HORA   -0.55882353 -1.66375838  0.5461113 0.8453599
X7.HORA-X2.HORA   -0.69117647 -1.79611132  0.4137584 0.6093767
X72.HORA-X2.HORA  -2.44117647 -3.54611132 -1.3362416 0.0000000
X3.HORA-X24.HORA   1.41176471  0.30682986  2.5166996 0.0022520
X4.HORA-X24.HORA   1.30882353  0.20388868  2.4137584 0.0070511
X48.HORA-X24.HORA -0.29411765 -1.39905250  0.8108172 0.9978177
X5.HORA-X24.HORA   1.17647059  0.07153574  2.2814054 0.0263895
X6.HORA-X24.HORA   1.13235294  0.02741809  2.2372878 0.0393903
X7.HORA-X24.HORA   1.00000000 -0.10493485  2.1049348 0.1152912
X72.HORA-X24.HORA -0.75000000 -1.85493485  0.3549348 0.4893057
X4.HORA-X3.HORA   -0.10294118 -1.20787603  1.0019937 0.9999997
X48.HORA-X3.HORA  -1.70588235 -2.81081720 -0.6009475 0.0000524
X5.HORA-X3.HORA   -0.23529412 -1.34022897  0.8696407 0.9996331
X6.HORA-X3.HORA   -0.27941176 -1.38434661  0.8255231 0.9985387
X7.HORA-X3.HORA   -0.41176471 -1.51669955  0.6931701 0.9747857
X72.HORA-X3.HORA  -2.16176471 -3.26669955 -1.0568299 0.0000000
X48.HORA-X4.HORA  -1.60294118 -2.70787603 -0.4980063 0.0002117
X5.HORA-X4.HORA   -0.13235294 -1.23728779  0.9725819 0.9999973
X6.HORA-X4.HORA   -0.17647059 -1.28140544  0.9284643 0.9999671
X7.HORA-X4.HORA   -0.30882353 -1.41375838  0.7961113 0.9968225
X72.HORA-X4.HORA  -2.05882353 -3.16375838 -0.9538887 0.0000002
X5.HORA-X48.HORA   1.47058824  0.36565339  2.5755231 0.0011243
X6.HORA-X48.HORA   1.42647059  0.32153574  2.5314054 0.0018983
X7.HORA-X48.HORA   1.29411765  0.18918280  2.3990525 0.0082338
X72.HORA-X48.HORA -0.45588235 -1.56081720  0.6490525 0.9513372
X6.HORA-X5.HORA   -0.04411765 -1.14905250  1.0608172 1.0000000
X7.HORA-X5.HORA   -0.17647059 -1.28140544  0.9284643 0.9999671
X72.HORA-X5.HORA  -1.92647059 -3.03140544 -0.8215357 0.0000020
X7.HORA-X6.HORA   -0.13235294 -1.23728779  0.9725819 0.9999973
X72.HORA-X6.HORA  -1.88235294 -2.98728779 -0.7774181 0.0000040
X72.HORA-X7.HORA  -1.75000000 -2.85493485 -0.6450652 0.0000281

$`df2$Medicamento`
                            diff       lwr       upr     p adj
Meloxicam -Ibuprofeno  0.6029412 0.2973022 0.9085802 0.0001179

$`df2$Hora:df2$Medicamento`
                                                   diff         lwr         upr     p adj
X2.HORA:Ibuprofeno -X1.HORA:Ibuprofeno    -4.117647e-01 -2.16331542  1.33978600 0.9999991
X24.HORA:Ibuprofeno -X1.HORA:Ibuprofeno   -1.588235e+00 -3.33978600  0.16331542 0.1333036
X3.HORA:Ibuprofeno -X1.HORA:Ibuprofeno    -5.882353e-01 -2.33978600  1.16331542 0.9997523
X4.HORA:Ibuprofeno -X1.HORA:Ibuprofeno    -6.176471e-01 -2.36919777  1.13390365 0.9995055
X48.HORA:Ibuprofeno -X1.HORA:Ibuprofeno   -1.735294e+00 -3.48684483  0.01625659 0.0555461
X5.HORA:Ibuprofeno -X1.HORA:Ibuprofeno    -5.882353e-01 -2.33978600  1.16331542 0.9997523
X6.HORA:Ibuprofeno -X1.HORA:Ibuprofeno    -5.588235e-01 -2.31037424  1.19272718 0.9998828
X7.HORA:Ibuprofeno -X1.HORA:Ibuprofeno    -5.588235e-01 -2.31037424  1.19272718 0.9998828
X72.HORA:Ibuprofeno -X1.HORA:Ibuprofeno   -2.117647e+00 -3.86919777 -0.36609635 0.0031671
X1.HORA:Meloxicam -X1.HORA:Ibuprofeno      1.088235e+00 -0.66331542  2.83978600 0.7929663
X2.HORA:Meloxicam -X1.HORA:Ibuprofeno      9.117647e-01 -0.83978600  2.66331542 0.9500622
X24.HORA:Meloxicam -X1.HORA:Ibuprofeno    -1.294118e+00 -3.04566836  0.45743306 0.4836985
X3.HORA:Meloxicam -X1.HORA:Ibuprofeno      5.294118e-01 -1.22213895  2.28096248 0.9999479
X4.HORA:Meloxicam -X1.HORA:Ibuprofeno      3.529412e-01 -1.39860953  2.10449189 0.9999999
X48.HORA:Meloxicam -X1.HORA:Ibuprofeno    -1.735294e+00 -3.48684483  0.01625659 0.0555461
X5.HORA:Meloxicam -X1.HORA:Ibuprofeno      5.882353e-02 -1.69272718  1.81037424 1.0000000
X6.HORA:Meloxicam -X1.HORA:Ibuprofeno     -5.882353e-02 -1.81037424  1.69272718 1.0000000
X7.HORA:Meloxicam -X1.HORA:Ibuprofeno     -3.235294e-01 -2.07508012  1.42802130 1.0000000
X72.HORA:Meloxicam -X1.HORA:Ibuprofeno    -2.264706e+00 -4.01625659 -0.51315517 0.0008664
X24.HORA:Ibuprofeno -X2.HORA:Ibuprofeno   -1.176471e+00 -2.92802130  0.57508012 0.6687117
X3.HORA:Ibuprofeno -X2.HORA:Ibuprofeno    -1.764706e-01 -1.92802130  1.57508012 1.0000000
X4.HORA:Ibuprofeno -X2.HORA:Ibuprofeno    -2.058824e-01 -1.95743306  1.54566836 1.0000000
X48.HORA:Ibuprofeno -X2.HORA:Ibuprofeno   -1.323529e+00 -3.07508012  0.42802130 0.4382857
X5.HORA:Ibuprofeno -X2.HORA:Ibuprofeno    -1.764706e-01 -1.92802130  1.57508012 1.0000000
X6.HORA:Ibuprofeno -X2.HORA:Ibuprofeno    -1.470588e-01 -1.89860953  1.60449189 1.0000000
X7.HORA:Ibuprofeno -X2.HORA:Ibuprofeno    -1.470588e-01 -1.89860953  1.60449189 1.0000000
X72.HORA:Ibuprofeno -X2.HORA:Ibuprofeno   -1.705882e+00 -3.45743306  0.04566836 0.0669131
X1.HORA:Meloxicam -X2.HORA:Ibuprofeno      1.500000e+00 -0.25155071  3.25155071 0.2101039
X2.HORA:Meloxicam -X2.HORA:Ibuprofeno      1.323529e+00 -0.42802130  3.07508012 0.4382857
X24.HORA:Meloxicam -X2.HORA:Ibuprofeno    -8.823529e-01 -2.63390365  0.86919777 0.9635623
X3.HORA:Meloxicam -X2.HORA:Ibuprofeno      9.411765e-01 -0.81037424  2.69272718 0.9332411
X4.HORA:Meloxicam -X2.HORA:Ibuprofeno      7.647059e-01 -0.98684483  2.51625659 0.9922382
X48.HORA:Meloxicam -X2.HORA:Ibuprofeno    -1.323529e+00 -3.07508012  0.42802130 0.4382857
X5.HORA:Meloxicam -X2.HORA:Ibuprofeno      4.705882e-01 -1.28096248  2.22213895 0.9999917
X6.HORA:Meloxicam -X2.HORA:Ibuprofeno      3.529412e-01 -1.39860953  2.10449189 0.9999999
X7.HORA:Meloxicam -X2.HORA:Ibuprofeno      8.823529e-02 -1.66331542  1.83978600 1.0000000
X72.HORA:Meloxicam -X2.HORA:Ibuprofeno    -1.852941e+00 -3.60449189 -0.10139047 0.0250439
X3.HORA:Ibuprofeno -X24.HORA:Ibuprofeno    1.000000e+00 -0.75155071  2.75155071 0.8885591
X4.HORA:Ibuprofeno -X24.HORA:Ibuprofeno    9.705882e-01 -0.78096248  2.72213895 0.9128042
X48.HORA:Ibuprofeno -X24.HORA:Ibuprofeno  -1.470588e-01 -1.89860953  1.60449189 1.0000000
X5.HORA:Ibuprofeno -X24.HORA:Ibuprofeno    1.000000e+00 -0.75155071  2.75155071 0.8885591
X6.HORA:Ibuprofeno -X24.HORA:Ibuprofeno    1.029412e+00 -0.72213895  2.78096248 0.8604364
X7.HORA:Ibuprofeno -X24.HORA:Ibuprofeno    1.029412e+00 -0.72213895  2.78096248 0.8604364
X72.HORA:Ibuprofeno -X24.HORA:Ibuprofeno  -5.294118e-01 -2.28096248  1.22213895 0.9999479
X1.HORA:Meloxicam -X24.HORA:Ibuprofeno     2.676471e+00  0.92491988  4.42802130 0.0000141
X2.HORA:Meloxicam -X24.HORA:Ibuprofeno     2.500000e+00  0.74844929  4.25155071 0.0000895
X24.HORA:Meloxicam -X24.HORA:Ibuprofeno    2.941176e-01 -1.45743306  2.04566836 1.0000000
X3.HORA:Meloxicam -X24.HORA:Ibuprofeno     2.117647e+00  0.36609635  3.86919777 0.0031671
X4.HORA:Meloxicam -X24.HORA:Ibuprofeno     1.941176e+00  0.18962576  3.69272718 0.0130892
X48.HORA:Meloxicam -X24.HORA:Ibuprofeno   -1.470588e-01 -1.89860953  1.60449189 1.0000000
X5.HORA:Meloxicam -X24.HORA:Ibuprofeno     1.647059e+00 -0.10449189  3.39860953 0.0955231
X6.HORA:Meloxicam -X24.HORA:Ibuprofeno     1.529412e+00 -0.22213895  3.28096248 0.1816559
X7.HORA:Meloxicam -X24.HORA:Ibuprofeno     1.264706e+00 -0.48684483  3.01625659 0.5300707
X72.HORA:Meloxicam -X24.HORA:Ibuprofeno   -6.764706e-01 -2.42802130  1.07508012 0.9983070
X4.HORA:Ibuprofeno -X3.HORA:Ibuprofeno    -2.941176e-02 -1.78096248  1.72213895 1.0000000
X48.HORA:Ibuprofeno -X3.HORA:Ibuprofeno   -1.147059e+00 -2.89860953  0.60449189 0.7125631
X5.HORA:Ibuprofeno -X3.HORA:Ibuprofeno    -2.087219e-14 -1.75155071  1.75155071 1.0000000
X6.HORA:Ibuprofeno -X3.HORA:Ibuprofeno     2.941176e-02 -1.72213895  1.78096248 1.0000000
X7.HORA:Ibuprofeno -X3.HORA:Ibuprofeno     2.941176e-02 -1.72213895  1.78096248 1.0000000
X72.HORA:Ibuprofeno -X3.HORA:Ibuprofeno   -1.529412e+00 -3.28096248  0.22213895 0.1816559
X1.HORA:Meloxicam -X3.HORA:Ibuprofeno      1.676471e+00 -0.07508012  3.42802130 0.0801705
X2.HORA:Meloxicam -X3.HORA:Ibuprofeno      1.500000e+00 -0.25155071  3.25155071 0.2101039
X24.HORA:Meloxicam -X3.HORA:Ibuprofeno    -7.058824e-01 -2.45743306  1.04566836 0.9970732
X3.HORA:Meloxicam -X3.HORA:Ibuprofeno      1.117647e+00 -0.63390365  2.86919777 0.7541665
X4.HORA:Meloxicam -X3.HORA:Ibuprofeno      9.411765e-01 -0.81037424  2.69272718 0.9332411
X48.HORA:Meloxicam -X3.HORA:Ibuprofeno    -1.147059e+00 -2.89860953  0.60449189 0.7125631
X5.HORA:Meloxicam -X3.HORA:Ibuprofeno      6.470588e-01 -1.10449189  2.39860953 0.9990629
X6.HORA:Meloxicam -X3.HORA:Ibuprofeno      5.294118e-01 -1.22213895  2.28096248 0.9999479
X7.HORA:Meloxicam -X3.HORA:Ibuprofeno      2.647059e-01 -1.48684483  2.01625659 1.0000000
X72.HORA:Meloxicam -X3.HORA:Ibuprofeno    -1.676471e+00 -3.42802130  0.07508012 0.0801705
X48.HORA:Ibuprofeno -X4.HORA:Ibuprofeno   -1.117647e+00 -2.86919777  0.63390365 0.7541665
X5.HORA:Ibuprofeno -X4.HORA:Ibuprofeno     2.941176e-02 -1.72213895  1.78096248 1.0000000
X6.HORA:Ibuprofeno -X4.HORA:Ibuprofeno     5.882353e-02 -1.69272718  1.81037424 1.0000000
X7.HORA:Ibuprofeno -X4.HORA:Ibuprofeno     5.882353e-02 -1.69272718  1.81037424 1.0000000
X72.HORA:Ibuprofeno -X4.HORA:Ibuprofeno   -1.500000e+00 -3.25155071  0.25155071 0.2101039
X1.HORA:Meloxicam -X4.HORA:Ibuprofeno      1.705882e+00 -0.04566836  3.45743306 0.0669131
X2.HORA:Meloxicam -X4.HORA:Ibuprofeno      1.529412e+00 -0.22213895  3.28096248 0.1816559
X24.HORA:Meloxicam -X4.HORA:Ibuprofeno    -6.764706e-01 -2.42802130  1.07508012 0.9983070
X3.HORA:Meloxicam -X4.HORA:Ibuprofeno      1.147059e+00 -0.60449189  2.89860953 0.7125631
X4.HORA:Meloxicam -X4.HORA:Ibuprofeno      9.705882e-01 -0.78096248  2.72213895 0.9128042
X48.HORA:Meloxicam -X4.HORA:Ibuprofeno    -1.117647e+00 -2.86919777  0.63390365 0.7541665
X5.HORA:Meloxicam -X4.HORA:Ibuprofeno      6.764706e-01 -1.07508012  2.42802130 0.9983070
X6.HORA:Meloxicam -X4.HORA:Ibuprofeno      5.588235e-01 -1.19272718  2.31037424 0.9998828
X7.HORA:Meloxicam -X4.HORA:Ibuprofeno      2.941176e-01 -1.45743306  2.04566836 1.0000000
X72.HORA:Meloxicam -X4.HORA:Ibuprofeno    -1.647059e+00 -3.39860953  0.10449189 0.0955231
X5.HORA:Ibuprofeno -X48.HORA:Ibuprofeno    1.147059e+00 -0.60449189  2.89860953 0.7125631
X6.HORA:Ibuprofeno -X48.HORA:Ibuprofeno    1.176471e+00 -0.57508012  2.92802130 0.6687117
X7.HORA:Ibuprofeno -X48.HORA:Ibuprofeno    1.176471e+00 -0.57508012  2.92802130 0.6687117
X72.HORA:Ibuprofeno -X48.HORA:Ibuprofeno  -3.823529e-01 -2.13390365  1.36919777 0.9999997
X1.HORA:Meloxicam -X48.HORA:Ibuprofeno     2.823529e+00  1.07197870  4.57508012 0.0000028
X2.HORA:Meloxicam -X48.HORA:Ibuprofeno     2.647059e+00  0.89550811  4.39860953 0.0000193
X24.HORA:Meloxicam -X48.HORA:Ibuprofeno    4.411765e-01 -1.31037424  2.19272718 0.9999971
X3.HORA:Meloxicam -X48.HORA:Ibuprofeno     2.264706e+00  0.51315517  4.01625659 0.0008664
X4.HORA:Meloxicam -X48.HORA:Ibuprofeno     2.088235e+00  0.33668458  3.83978600 0.0040552
X48.HORA:Meloxicam -X48.HORA:Ibuprofeno    5.773160e-15 -1.75155071  1.75155071 1.0000000
X5.HORA:Meloxicam -X48.HORA:Ibuprofeno     1.794118e+00  0.04256694  3.54566836 0.0376775
X6.HORA:Meloxicam -X48.HORA:Ibuprofeno     1.676471e+00 -0.07508012  3.42802130 0.0801705
X7.HORA:Meloxicam -X48.HORA:Ibuprofeno     1.411765e+00 -0.33978600  3.16331542 0.3127654
X72.HORA:Meloxicam -X48.HORA:Ibuprofeno   -5.294118e-01 -2.28096248  1.22213895 0.9999479
X6.HORA:Ibuprofeno -X5.HORA:Ibuprofeno     2.941176e-02 -1.72213895  1.78096248 1.0000000
X7.HORA:Ibuprofeno -X5.HORA:Ibuprofeno     2.941176e-02 -1.72213895  1.78096248 1.0000000
X72.HORA:Ibuprofeno -X5.HORA:Ibuprofeno   -1.529412e+00 -3.28096248  0.22213895 0.1816559
X1.HORA:Meloxicam -X5.HORA:Ibuprofeno      1.676471e+00 -0.07508012  3.42802130 0.0801705
X2.HORA:Meloxicam -X5.HORA:Ibuprofeno      1.500000e+00 -0.25155071  3.25155071 0.2101039
X24.HORA:Meloxicam -X5.HORA:Ibuprofeno    -7.058824e-01 -2.45743306  1.04566836 0.9970732
X3.HORA:Meloxicam -X5.HORA:Ibuprofeno      1.117647e+00 -0.63390365  2.86919777 0.7541665
X4.HORA:Meloxicam -X5.HORA:Ibuprofeno      9.411765e-01 -0.81037424  2.69272718 0.9332411
X48.HORA:Meloxicam -X5.HORA:Ibuprofeno    -1.147059e+00 -2.89860953  0.60449189 0.7125631
X5.HORA:Meloxicam -X5.HORA:Ibuprofeno      6.470588e-01 -1.10449189  2.39860953 0.9990629
X6.HORA:Meloxicam -X5.HORA:Ibuprofeno      5.294118e-01 -1.22213895  2.28096248 0.9999479
X7.HORA:Meloxicam -X5.HORA:Ibuprofeno      2.647059e-01 -1.48684483  2.01625659 1.0000000
X72.HORA:Meloxicam -X5.HORA:Ibuprofeno    -1.676471e+00 -3.42802130  0.07508012 0.0801705
X7.HORA:Ibuprofeno -X6.HORA:Ibuprofeno    -3.108624e-15 -1.75155071  1.75155071 1.0000000
X72.HORA:Ibuprofeno -X6.HORA:Ibuprofeno   -1.558824e+00 -3.31037424  0.19272718 0.1560866
X1.HORA:Meloxicam -X6.HORA:Ibuprofeno      1.647059e+00 -0.10449189  3.39860953 0.0955231
X2.HORA:Meloxicam -X6.HORA:Ibuprofeno      1.470588e+00 -0.28096248  3.22213895 0.2414689
X24.HORA:Meloxicam -X6.HORA:Ibuprofeno    -7.352941e-01 -2.48684483  1.01625659 0.9951426
X3.HORA:Meloxicam -X6.HORA:Ibuprofeno      1.088235e+00 -0.66331542  2.83978600 0.7929663
X4.HORA:Meloxicam -X6.HORA:Ibuprofeno      9.117647e-01 -0.83978600  2.66331542 0.9500622
X48.HORA:Meloxicam -X6.HORA:Ibuprofeno    -1.176471e+00 -2.92802130  0.57508012 0.6687117
X5.HORA:Meloxicam -X6.HORA:Ibuprofeno      6.176471e-01 -1.13390365  2.36919777 0.9995055
X6.HORA:Meloxicam -X6.HORA:Ibuprofeno      5.000000e-01 -1.25155071  2.25155071 0.9999784
X7.HORA:Meloxicam -X6.HORA:Ibuprofeno      2.352941e-01 -1.51625659  1.98684483 1.0000000
X72.HORA:Meloxicam -X6.HORA:Ibuprofeno    -1.705882e+00 -3.45743306  0.04566836 0.0669131
X72.HORA:Ibuprofeno -X7.HORA:Ibuprofeno   -1.558824e+00 -3.31037424  0.19272718 0.1560866
X1.HORA:Meloxicam -X7.HORA:Ibuprofeno      1.647059e+00 -0.10449189  3.39860953 0.0955231
X2.HORA:Meloxicam -X7.HORA:Ibuprofeno      1.470588e+00 -0.28096248  3.22213895 0.2414689
X24.HORA:Meloxicam -X7.HORA:Ibuprofeno    -7.352941e-01 -2.48684483  1.01625659 0.9951426
X3.HORA:Meloxicam -X7.HORA:Ibuprofeno      1.088235e+00 -0.66331542  2.83978600 0.7929663
X4.HORA:Meloxicam -X7.HORA:Ibuprofeno      9.117647e-01 -0.83978600  2.66331542 0.9500622
X48.HORA:Meloxicam -X7.HORA:Ibuprofeno    -1.176471e+00 -2.92802130  0.57508012 0.6687117
X5.HORA:Meloxicam -X7.HORA:Ibuprofeno      6.176471e-01 -1.13390365  2.36919777 0.9995055
X6.HORA:Meloxicam -X7.HORA:Ibuprofeno      5.000000e-01 -1.25155071  2.25155071 0.9999784
X7.HORA:Meloxicam -X7.HORA:Ibuprofeno      2.352941e-01 -1.51625659  1.98684483 1.0000000
X72.HORA:Meloxicam -X7.HORA:Ibuprofeno    -1.705882e+00 -3.45743306  0.04566836 0.0669131
X1.HORA:Meloxicam -X72.HORA:Ibuprofeno     3.205882e+00  1.45433164  4.95743306 0.0000000
X2.HORA:Meloxicam -X72.HORA:Ibuprofeno     3.029412e+00  1.27786105  4.78096248 0.0000002
X24.HORA:Meloxicam -X72.HORA:Ibuprofeno    8.235294e-01 -0.92802130  2.57508012 0.9821223
X3.HORA:Meloxicam -X72.HORA:Ibuprofeno     2.647059e+00  0.89550811  4.39860953 0.0000193
X4.HORA:Meloxicam -X72.HORA:Ibuprofeno     2.470588e+00  0.71903752  4.22213895 0.0001204
X48.HORA:Meloxicam -X72.HORA:Ibuprofeno    3.823529e-01 -1.36919777  2.13390365 0.9999997
X5.HORA:Meloxicam -X72.HORA:Ibuprofeno     2.176471e+00  0.42491988  3.92802130 0.0019083
X6.HORA:Meloxicam -X72.HORA:Ibuprofeno     2.058824e+00  0.30727282  3.81037424 0.0051707
X7.HORA:Meloxicam -X72.HORA:Ibuprofeno     1.794118e+00  0.04256694  3.54566836 0.0376775
X72.HORA:Meloxicam -X72.HORA:Ibuprofeno   -1.470588e-01 -1.89860953  1.60449189 1.0000000
X2.HORA:Meloxicam -X1.HORA:Meloxicam      -1.764706e-01 -1.92802130  1.57508012 1.0000000
X24.HORA:Meloxicam -X1.HORA:Meloxicam     -2.382353e+00 -4.13390365 -0.63080223 0.0002867
X3.HORA:Meloxicam -X1.HORA:Meloxicam      -5.588235e-01 -2.31037424  1.19272718 0.9998828
X4.HORA:Meloxicam -X1.HORA:Meloxicam      -7.352941e-01 -2.48684483  1.01625659 0.9951426
X48.HORA:Meloxicam -X1.HORA:Meloxicam     -2.823529e+00 -4.57508012 -1.07197870 0.0000028
X5.HORA:Meloxicam -X1.HORA:Meloxicam      -1.029412e+00 -2.78096248  0.72213895 0.8604364
X6.HORA:Meloxicam -X1.HORA:Meloxicam      -1.147059e+00 -2.89860953  0.60449189 0.7125631
X7.HORA:Meloxicam -X1.HORA:Meloxicam      -1.411765e+00 -3.16331542  0.33978600 0.3127654
X72.HORA:Meloxicam -X1.HORA:Meloxicam     -3.352941e+00 -5.10449189 -1.60139047 0.0000000
X24.HORA:Meloxicam -X2.HORA:Meloxicam     -2.205882e+00 -3.95743306 -0.45433164 0.0014724
X3.HORA:Meloxicam -X2.HORA:Meloxicam      -3.823529e-01 -2.13390365  1.36919777 0.9999997
X4.HORA:Meloxicam -X2.HORA:Meloxicam      -5.588235e-01 -2.31037424  1.19272718 0.9998828
X48.HORA:Meloxicam -X2.HORA:Meloxicam     -2.647059e+00 -4.39860953 -0.89550811 0.0000193
X5.HORA:Meloxicam -X2.HORA:Meloxicam      -8.529412e-01 -2.60449189  0.89860953 0.9741109
X6.HORA:Meloxicam -X2.HORA:Meloxicam      -9.705882e-01 -2.72213895  0.78096248 0.9128042
X7.HORA:Meloxicam -X2.HORA:Meloxicam      -1.235294e+00 -2.98684483  0.51625659 0.5767996
X72.HORA:Meloxicam -X2.HORA:Meloxicam     -3.176471e+00 -4.92802130 -1.42491988 0.0000000
X3.HORA:Meloxicam -X24.HORA:Meloxicam      1.823529e+00  0.07197870  3.57508012 0.0307942
X4.HORA:Meloxicam -X24.HORA:Meloxicam      1.647059e+00 -0.10449189  3.39860953 0.0955231
X48.HORA:Meloxicam -X24.HORA:Meloxicam    -4.411765e-01 -2.19272718  1.31037424 0.9999971
X5.HORA:Meloxicam -X24.HORA:Meloxicam      1.352941e+00 -0.39860953  3.10449189 0.3943692
X6.HORA:Meloxicam -X24.HORA:Meloxicam      1.235294e+00 -0.51625659  2.98684483 0.5767996
X7.HORA:Meloxicam -X24.HORA:Meloxicam      9.705882e-01 -0.78096248  2.72213895 0.9128042
X72.HORA:Meloxicam -X24.HORA:Meloxicam    -9.705882e-01 -2.72213895  0.78096248 0.9128042
X4.HORA:Meloxicam -X3.HORA:Meloxicam      -1.764706e-01 -1.92802130  1.57508012 1.0000000
X48.HORA:Meloxicam -X3.HORA:Meloxicam     -2.264706e+00 -4.01625659 -0.51315517 0.0008664
X5.HORA:Meloxicam -X3.HORA:Meloxicam      -4.705882e-01 -2.22213895  1.28096248 0.9999917
X6.HORA:Meloxicam -X3.HORA:Meloxicam      -5.882353e-01 -2.33978600  1.16331542 0.9997523
X7.HORA:Meloxicam -X3.HORA:Meloxicam      -8.529412e-01 -2.60449189  0.89860953 0.9741109
X72.HORA:Meloxicam -X3.HORA:Meloxicam     -2.794118e+00 -4.54566836 -1.04256694 0.0000038
X48.HORA:Meloxicam -X4.HORA:Meloxicam     -2.088235e+00 -3.83978600 -0.33668458 0.0040552
X5.HORA:Meloxicam -X4.HORA:Meloxicam      -2.941176e-01 -2.04566836  1.45743306 1.0000000
X6.HORA:Meloxicam -X4.HORA:Meloxicam      -4.117647e-01 -2.16331542  1.33978600 0.9999991
X7.HORA:Meloxicam -X4.HORA:Meloxicam      -6.764706e-01 -2.42802130  1.07508012 0.9983070
X72.HORA:Meloxicam -X4.HORA:Meloxicam     -2.617647e+00 -4.36919777 -0.86609635 0.0000264
X5.HORA:Meloxicam -X48.HORA:Meloxicam      1.794118e+00  0.04256694  3.54566836 0.0376775
X6.HORA:Meloxicam -X48.HORA:Meloxicam      1.676471e+00 -0.07508012  3.42802130 0.0801705
X7.HORA:Meloxicam -X48.HORA:Meloxicam      1.411765e+00 -0.33978600  3.16331542 0.3127654
X72.HORA:Meloxicam -X48.HORA:Meloxicam    -5.294118e-01 -2.28096248  1.22213895 0.9999479
X6.HORA:Meloxicam -X5.HORA:Meloxicam      -1.176471e-01 -1.86919777  1.63390365 1.0000000
X7.HORA:Meloxicam -X5.HORA:Meloxicam      -3.823529e-01 -2.13390365  1.36919777 0.9999997
X72.HORA:Meloxicam -X5.HORA:Meloxicam     -2.323529e+00 -4.07508012 -0.57197870 0.0005021
X7.HORA:Meloxicam -X6.HORA:Meloxicam      -2.647059e-01 -2.01625659  1.48684483 1.0000000
X72.HORA:Meloxicam -X6.HORA:Meloxicam     -2.205882e+00 -3.95743306 -0.45433164 0.0014724
X72.HORA:Meloxicam -X7.HORA:Meloxicam     -1.941176e+00 -3.69272718 -0.18962576 0.0130892

print(posthoc)

    Pairwise comparisons using t tests with pooled SD 

data:  df2$EVA and df2$Medicamento 

           Ibuprofeno 
Meloxicam  0.00036    

P value adjustment method: bonferroni