| Characteristic | Overall N = 4051 |
With AVN N = 881 |
Without AVN N = 3171 |
p-value2 |
|---|---|---|---|---|
| Age (yr) | 35 (25, 47) | 40 (32, 48) | 34 (24, 47) | 0.007 |
| Female | 189 (47%) | 42 (48%) | 147 (46%) | 0.8 |
| Sickle Cell Type | 0.7 | |||
| SS | 297 (73%) | 66 (75%) | 231 (73%) | |
| SC | 72 (18%) | 13 (15%) | 59 (19%) | |
| SB+ (thalassemia) | 16 (4.0%) | 5 (5.7%) | 11 (3.5%) | |
| Other | 20 (4.9%) | 4 (4.5%) | 16 (5.0%) | |
| Alpha-thalassemia | 0.15 | |||
| Wild Type | 274 (68%) | 57 (65%) | 217 (68%) | |
| One Deletion | 123 (30%) | 27 (31%) | 96 (30%) | |
| Two Deletions | 8 (2.0%) | 4 (4.5%) | 4 (1.3%) | |
| Current Hydroxyurea Use | 165 (41%) | 45 (51%) | 120 (38%) | 0.025 |
| Hemoglobin F (%) | 5 (2, 10) | 7 (2, 13) | 4 (2, 9) | 0.038 |
| Hematocrit (%) | 26.9 (22.7, 31.5) | 27.9 (24.0, 31.0) | 26.4 (22.2, 31.5) | 0.3 |
| Hemoglobin (g/dL) | 9.2 (8.0, 10.8) | 9.4 (8.4, 10.9) | 9.1 (7.8, 10.8) | 0.4 |
| White Blood Cells (cells/µL) | 9.5 (7.4, 12.1) | 9.5 (7.0, 12.2) | 9.5 (7.5, 11.9) | 0.8 |
| History of Smoking | 126 (31%) | 35 (40%) | 91 (29%) | 0.047 |
| Presence of Chronic Pain | 146 (36%) | 47 (53%) | 99 (31%) | <0.001 |
| Number of VOC Episodes/Year | 1 (0, 2) | 1 (0, 3) | 1 (0, 2) | 0.007 |
| BMI | 23.7 (21.3, 27.4) | 24.4 (22.7, 27.7) | 23.5 (20.9, 27.1) | 0.067 |
| 1 Median (IQR); n (%) | ||||
| 2 Wilcoxon rank sum test; Pearson’s Chi-squared test; Fisher’s exact test | ||||