| Non-CT (N=487) | CT (N=19) | p-value | |
|---|---|---|---|
| Hypercoagulable Disorder - No | 471(96.7%) | 17(89.5%) | 0.1429 |
| Hypercoagulable Disorder - Yes | 16(3.3%) | 2(10.5%) | |
| Filter Indication - Anticoagulation Failure | 41(8.4%) | 2(10.5%) | 0.0276 |
| Filter Indication - Calf DVT or PE with contraindication to anticoagulation | 383(78.6%) | 15(78.9%) | |
| Filter Indication - Other | 7(1.4%) | 2(10.5%) | |
| Filter Indication - Prophylactic | 56(11.5%) | 0(0%) | |
| Dwell time (days) | 106 (70, 160) | 220 (159, 303) | 0.002 |
| Retrieval Intent - Non-Perm | 328(67.4%) | 14(73.7%) | 0.6281 |
| Retrieval Intent - Perm | 159(32.6%) | 5(26.3%) | |
| Age (years) | 64 (53, 71) | 58 (49.5, 64.5) | 0.163 |
| Sex - Female | 202(41.5%) | 8(42.1%) | 1 |
| Sex - Male | 285(58.5%) | 11(57.9%) | |
| Clot Location - Calf | 31(6.4%) | 2(10.5%) | 0.377 |
| Clot Location - Iliocaval | 21(4.3%) | 1(5.3%) | |
| Clot Location - Iliocaval and pulmonary embolus | 5(1%) | 1(5.3%) | |
| Clot Location - Leg | 196(40.2%) | 8(42.1%) | |
| Clot Location - Leg and pulmonary embolus | 112(23%) | 2(10.5%) | |
| Clot Location - Pulmonary embolus | 115(23.6%) | 5(26.3%) | |
| Clot Location - Not applicable | 7(1.4%) | 0(0%) | |
| Follow-up time (days) | 52.5 (9.8, 193.5) | 663 (218.5, 729) | 0.009 |
Denali IVC filter study
Statistical analysis
Variables are compared between caval thrombosis vs non-caval thrombosis and between worsening clot vs non-worsening clot below. Quantitative variables are summarized by median (inter-quartile range; IQR) and tested by the Wilcoxon rank sum test; Categorical variables are summarized by N (%) and tested by the Fisher exact test.
Variable correlations with caval thrombosis
Variable correlations with worsening clot
| Non-WC (N=456) | WC (N=50) | p-value | |
|---|---|---|---|
| Hypercoagulable Disorder - No | 440(96.5%) | 48(96%) | 0.6954 |
| Hypercoagulable Disorder - Yes | 16(3.5%) | 2(4%) | |
| Filter Indication - Anticoagulation Failure | 39(8.6%) | 4(8%) | 0.5143 |
| Filter Indication - Calf DVT or PE with contraindication to anticoagulation | 360(78.9%) | 38(76%) | |
| Filter Indication - Other | 7(1.5%) | 2(4%) | |
| Filter Indication - Prophylactic | 50(11%) | 6(12%) | |
| Dwell time (days) | 106 (69.8, 154) | 160 (76, 240.5) | 0.018 |
| Retrieval Intent - Non-perm | 306(67.1%) | 36(72%) | 0.5281 |
| Retrieval Attempted - Perm | 150(32.9%) | 14(28%) | |
| Age (years) | 64 (53, 71) | 61 (50.2, 69) | 0.204 |
| Sex - Female | 189(41.4%) | 21(42%) | 1 |
| Sex - Male | 267(58.6%) | 29(58%) | |
| Clot Location - Calf | 28(6.1%) | 5(10%) | 0.3 |
| Clot Location - Iliocaval | 19(4.2%) | 3(6%) | |
| Clot Location - Iliocaval and pulmonary embolus | 4(0.9%) | 2(4%) | |
| Clot Location - Leg | 187(41%) | 17(34%) | |
| Clot Location - Leg and pulmonary embolus | 104(22.8%) | 10(20%) | |
| Clot Location - Pulmonary embolus | 108(23.7%) | 12(24%) | |
| Clot Location - Not applicable | 6(1.3%) | 1(2%) | |
| Follow-up time (days) | 56 (10.5, 226.2) | 182 (165, 340) | 0.153 |
Kaplan–Meier curve for thrombosis
The Kaplan–Meier curve for caval thrombosis/occlusion is plotted below.
