| Multivariate model fitting comparisons to test the relative contributions of additive genetic (A), common environment (C), and non-shared environmental (E) influences, including PRSs | |||||||||||||
| Model | ep | -2LL | df | Δ2LL | Δdf | p | AIC | Submodel | A | C | E | β21-ROI PRS | β31-SU PRS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nucleus Accumbens | |||||||||||||
| ACE+β21+β31 | 11.00 | 14 007.25 | 5 167.00 | - | - | - | 14 029.25 | ACE | 0.716(0.548 - 0.884) | -0.017(-0.152 - 0.116) | 0.287(0.24 - 0.347) | 0.088(0.039 - 0.137) | 0.051(0.002 - 0.099) |
| AE+β21 | 9.00 | 14 011.42 | 5 169.00 | 4.11 | 1.00 | 0.04 | 14 029.42 | AE | 0.698(0.615 - 0.783) | - | 0(0 - 0) | 0.05(0.002 - 0.099) | 0.004(-0.044 - 0.052) |
| AE+β21+β31 | 10.00 | 14 007.31 | 5 168.00 | - | - | - | 14 027.31 | AE | 0.698(0.615 - 0.783) | - | 0(0 - 0) | 0.05(0.002 - 0.099) | 0.004(-0.044 - 0.052) |
| AE+β31 | 9.00 | 14 019.84 | 5 169.00 | 12.53 | 1.00 | 0.00 | 14 037.84 | AE | 0.698(0.615 - 0.783) | - | 0(0 - 0) | 0.05(0.002 - 0.099) | 0.004(-0.044 - 0.052) |
| CE+β21+β31 | 10.00 | 14 060.08 | 5 168.00 | - | - | - | 14 080.08 | CE | - | 0.427(0.361 - 0.5) | 0.56(0.512 - 0.614) | 0.086(0.038 - 0.134) | 0.048(0.001 - 0.096) |
| E+β21+β31 | 9.00 | 14 254.54 | 5 169.00 | - | - | - | 14 272.54 | E | - | - | 0.987(0.927 - 1.053) | 0.089(0.044 - 0.134) | 0.053(0.008 - 0.099) |
| Cortical Surface Area | |||||||||||||
| ACE+β21+β31 | 11.00 | - | 5 164.00 | - | - | - | 13 675.67 | ACE | 0.533(0.419 - 0.649) | - | 0.182(0.152 - 0.22) | 0.126(0.079 - 0.174) | 0.062(0.015 - 0.109) |
| Cortical Thickness | |||||||||||||
| AE+β21 | 8.00 | - | 5 167.00 | - | 1.00 | 0.38 | 13 939.14 | AE | 0.684(0.606 - 0.765) | - | 0(0 - 0) | 0.195(0.147 - 0.244) | -0.022(-0.07 - 0.026) |
| Caudate | |||||||||||||
| AE+β21+β31 | 10.00 | 13 746.03 | 5 168.00 | 0.61 | 1.00 | 0.44 | 13 766.03 | AE | 0.806(0.737 - 0.88) | - | 0.143(0.12 - 0.171) | - | - |
| Amygdala | |||||||||||||
| AE+β21+β31 | 10.00 | 14 013.80 | 5 168.00 | 0.98 | 1.00 | 0.32 | 14 033.80 | AE | 0.698(0.615 - 0.783) | - | 0.29(0.246 - 0.344) | 0.088(0.039 - 0.137) | 0.05(0.002 - 0.099) |
| Hippocampus | |||||||||||||
| AE+β21+β31 | 9.00 | - | 5 169.00 | - | - | - | 13 966.01 | AE | 0.755(0.678 - 0.837) | - | 0.228(0.192 - 0.271) | 0.135(0.086 - 0.184) | 0.005(-0.044 - 0.054) |
| Putamen | |||||||||||||
| AE+β21 | 9.00 | - | 5 169.00 | - | 1.00 | 0.22 | 13 629.20 | AE | 0.872(0.806 - 0.944) | - | 0.089(0.074 - 0.107) | 0.196(0.148 - 0.244) | 0.03(-0.018 - 0.078) |
| Thalamus | |||||||||||||
| AE+β21 | 9.00 | - | 5 169.00 | - | 1.00 | 0.17 | 13 975.50 | AE | 0.691(0.597 - 0.787) | - | 0.311(0.258 - 0.377) | 0.112(0.061 - 0.162) | 0.029(-0.021 - 0.079) |
| Note: * adjusted for age, sex, total intracranial volume, and the top 10 genetic principal components. PRS = Nucleus Accumbens , SU&SUD = ep = number of estimated parameters, -2LL = -2 x log-likelihood, Δ-2LL = change in -2 x log-likelihood, Δdf = change in degrees of freedom, AIC = Akaike Information Criteria, β21=causal path from corresponding brain structure PRS to brain structure, β31=causal path from SU/SUD PRS to brain structure | |||||||||||||