TEDD Fluctuations
Karl Brown
2024-04-29
TEDD Analysis
Table 1
| AD (N=8) |
DLB (N=11) |
P-value | |
|---|---|---|---|
| Daily activity counts | |||
| Mean (SD) | 1620000 (232000) | 1240000 (473000) | 0.035 |
| Median [Min, Max] | 1620000 [1290000, 1950000] | 1370000 [407000, 1860000] | |
| Day activity | |||
| Mean (SD) | 868000 (160000) | 649000 (264000) | 0.039 |
| Median [Min, Max] | 876000 [657000, 1100000] | 740000 [238000, 931000] | |
| Night activity | |||
| Mean (SD) | 153000 (73300) | 122000 (84400) | 0.407 |
| Median [Min, Max] | 134000 [71700, 305000] | 95500 [29900, 262000] | |
| Drowsy | |||
| No | 5 (62.5%) | 2 (18.2%) | 0.135 |
| Yes | 3 (37.5%) | 9 (81.8%) | |
| Nap | |||
| No | 7 (87.5%) | 5 (45.5%) | 0.163 |
| Yes | 1 (12.5%) | 6 (54.5%) | |
| Illogical | |||
| No | 3 (37.5%) | 0 (0%) | 0.115 |
| Yes | 5 (62.5%) | 11 (100%) | |
| Stare | |||
| No | 6 (75.0%) | 4 (36.4%) | 0.23 |
| Yes | 2 (25.0%) | 7 (63.6%) | |
| Fluctuator | |||
| No | 6 (75.0%) | 2 (18.2%) | 0.045 |
| Yes | 2 (25.0%) | 9 (81.8%) | |
| Hallucinations | |||
| No | 8 (100%) | 2 (18.2%) | 0.002 |
| Yes | 0 (0%) | 9 (81.8%) | |
| Delusions | |||
| No | 8 (100%) | 5 (45.5%) | 0.043 |
| Yes | 0 (0%) | 6 (54.5%) |
##
## Welch Two Sample t-test
##
## data: act_fluc$daily_counts by act_fluc$Status
## t = 2.3105, df = 15.309, p-value = 0.03518
## alternative hypothesis: true difference in means between group AD and group DLB is not equal to 0
## 95 percent confidence interval:
## 30043.74 729443.23
## sample estimates:
## mean in group AD mean in group DLB
## 1617650 1237907Exploratory figures
Other activity measures
High intradaily variability may indicate daytime napping and/or nighttime arousals
Values range from 0 to 1, with higher values indicating greater stability
UPDRS
MoCA
NPI
##
## H: No H: Yes
## MF: No 8 0
## MF: Yes 2 9##
## D: No D: Yes
## MF: No 8 0
## MF: Yes 5 6
AAI
## # A tibble: 15 × 3
## newID AA_Over Status
## <chr> <dbl> <chr>
## 1 001 65.6 AD
## 2 003 8.2 DLB
## 3 005 80.1 AD
## 4 006 0 AD
## 5 007 18.3 DLB
## 6 008 3.2 DLB
## 7 011 32.3 AD
## 8 012 3.30 DLB
## 9 014 34.9 DLB
## 10 016 8.4 AD
## 11 017 20.9 AD
## 12 018 17.1 AD
## 13 019 22.1 DLB
## 14 020 4.62 DLB
## 15 022 6.19 DLB
Cleaveland Clinic Analysis
| Overall (N=171) |
|
|---|---|
| Baseline age | |
| Mean (SD) | 70.3 (6.51) |
| Median [Min, Max] | 70.0 [55.0, 89.0] |
| Missing | 1 (0.6%) |
| Gender | |
| 1 | 146 (85.4%) |
| 2 | 24 (14.0%) |
| Missing | 1 (0.6%) |
| Baseline MoCA | |
| Mean (SD) | 19.7 (5.69) |
| Median [Min, Max] | 21.0 [6.00, 30.0] |
| Missing | 6 (3.5%) |
| Baseline question 1 | |
| 0 | 44 (25.7%) |
| 1 | 91 (53.2%) |
| 9 | 3 (1.8%) |
| Missing | 33 (19.3%) |
| Baseline question 2 | |
| 0 | 67 (39.2%) |
| 1 | 66 (38.6%) |
| 9 | 5 (2.9%) |
| Missing | 33 (19.3%) |
| Baseline question 3 | |
| 0 | 28 (16.4%) |
| 1 | 108 (63.2%) |
| 9 | 2 (1.2%) |
| Missing | 33 (19.3%) |
| Baseline question 4 | |
| 0 | 63 (36.8%) |
| 1 | 70 (40.9%) |
| 9 | 5 (2.9%) |
| Missing | 33 (19.3%) |
| Fluctuator (baseline) | |
| No | 66 (38.6%) |
| Yes | 71 (41.5%) |
| Missing | 34 (19.9%) |
| Fluctuator (month 12) | |
| No | 26 (15.2%) |
| Yes | 53 (31.0%) |
| Missing | 92 (53.8%) |
| Fluctuator (month 24) | |
| No | 20 (11.7%) |
| Yes | 35 (20.5%) |
| Missing | 116 (67.8%) |
| Fluctuator (month 36) | |
| No | 14 (8.2%) |
| Yes | 17 (9.9%) |
| Missing | 140 (81.9%) |
| Baseline UPDRS score | |
| Mean (SD) | 28.9 (15.7) |
| Median [Min, Max] | 27.0 [0, 80.0] |
| Missing | 12 (7.0%) |
| Month 12 UPDRS score | |
| Mean (SD) | 30.2 (17.6) |
| Median [Min, Max] | 28.0 [2.00, 87.0] |
| Missing | 80 (46.8%) |
| Month 24 UPDRS score | |
| Mean (SD) | 33.4 (19.3) |
| Median [Min, Max] | 31.0 [1.00, 83.0] |
| Missing | 116 (67.8%) |
| Month 36 UPDRS score | |
| Mean (SD) | 33.3 (17.7) |
| Median [Min, Max] | 32.5 [2.00, 71.0] |
| Missing | 141 (82.5%) |
Table 1 by baseline fluctuation status
| No (N=66) |
Yes (N=71) |
Overall (N=137) |
|
|---|---|---|---|
| Baseline age | |||
| Mean (SD) | 69.8 (6.35) | 70.5 (6.38) | 70.2 (6.35) |
| Median [Min, Max] | 70.0 [57.0, 84.0] | 70.0 [55.0, 86.0] | 70.0 [55.0, 86.0] |
| Gender | |||
| 1 | 57 (86.4%) | 60 (84.5%) | 117 (85.4%) |
| 2 | 9 (13.6%) | 11 (15.5%) | 20 (14.6%) |
| Baseline MoCA | |||
| Mean (SD) | 21.3 (5.15) | 19.2 (5.80) | 20.2 (5.58) |
| Median [Min, Max] | 22.0 [10.0, 30.0] | 20.0 [7.00, 29.0] | 21.0 [7.00, 30.0] |
| Missing | 2 (3.0%) | 1 (1.4%) | 3 (2.2%) |
| Baseline question 1 | |||
| 0 | 42 (63.6%) | 2 (2.8%) | 44 (32.1%) |
| 1 | 22 (33.3%) | 69 (97.2%) | 91 (66.4%) |
| 9 | 1 (1.5%) | 0 (0%) | 1 (0.7%) |
| Missing | 1 (1.5%) | 0 (0%) | 1 (0.7%) |
| Baseline question 2 | |||
| 0 | 49 (74.2%) | 18 (25.4%) | 67 (48.9%) |
| 1 | 13 (19.7%) | 53 (74.6%) | 66 (48.2%) |
| 9 | 3 (4.5%) | 0 (0%) | 3 (2.2%) |
| Missing | 1 (1.5%) | 0 (0%) | 1 (0.7%) |
| Baseline question 3 | |||
| 0 | 28 (42.4%) | 0 (0%) | 28 (20.4%) |
| 1 | 37 (56.1%) | 71 (100%) | 108 (78.8%) |
| 9 | 0 (0%) | 0 (0%) | 0 (0%) |
| Missing | 1 (1.5%) | 0 (0%) | 1 (0.7%) |
| Baseline question 4 | |||
| 0 | 48 (72.7%) | 15 (21.1%) | 63 (46.0%) |
| 1 | 16 (24.2%) | 54 (76.1%) | 70 (51.1%) |
| 9 | 1 (1.5%) | 2 (2.8%) | 3 (2.2%) |
| Missing | 1 (1.5%) | 0 (0%) | 1 (0.7%) |
| Fluctuator (baseline) | |||
| No | 66 (100%) | 0 (0%) | 66 (48.2%) |
| Yes | 0 (0%) | 71 (100%) | 71 (51.8%) |
| Fluctuator (month 12) | |||
| No | 16 (24.2%) | 9 (12.7%) | 25 (18.2%) |
| Yes | 17 (25.8%) | 32 (45.1%) | 49 (35.8%) |
| Missing | 33 (50.0%) | 30 (42.3%) | 63 (46.0%) |
| Fluctuator (month 24) | |||
| No | 14 (21.2%) | 5 (7.0%) | 19 (13.9%) |
| Yes | 13 (19.7%) | 19 (26.8%) | 32 (23.4%) |
| Missing | 39 (59.1%) | 47 (66.2%) | 86 (62.8%) |
| Fluctuator (month 36) | |||
| No | 6 (9.1%) | 4 (5.6%) | 10 (7.3%) |
| Yes | 8 (12.1%) | 9 (12.7%) | 17 (12.4%) |
| Missing | 52 (78.8%) | 58 (81.7%) | 110 (80.3%) |
| Baseline UPDRS score | |||
| Mean (SD) | 27.0 (18.0) | 29.0 (13.6) | 28.1 (15.8) |
| Median [Min, Max] | 25.0 [0, 80.0] | 28.5 [2.00, 68.0] | 27.0 [0, 80.0] |
| Missing | 5 (7.6%) | 1 (1.4%) | 6 (4.4%) |
| Month 12 UPDRS score | |||
| Mean (SD) | 29.0 (22.1) | 29.7 (13.5) | 29.4 (18.1) |
| Median [Min, Max] | 26.0 [2.00, 87.0] | 30.5 [5.00, 60.0] | 28.0 [2.00, 87.0] |
| Missing | 33 (50.0%) | 37 (52.1%) | 70 (51.1%) |
| Month 24 UPDRS score | |||
| Mean (SD) | 29.3 (20.1) | 36.1 (18.5) | 32.6 (19.4) |
| Median [Min, Max] | 29.0 [1.00, 83.0] | 33.0 [3.00, 75.0] | 31.0 [1.00, 83.0] |
| Missing | 45 (68.2%) | 51 (71.8%) | 96 (70.1%) |
| Month 36 UPDRS score | |||
| Mean (SD) | 26.0 (16.7) | 38.2 (15.1) | 31.5 (16.8) |
| Median [Min, Max] | 28.0 [2.00, 54.0] | 39.0 [7.00, 57.0] | 34.0 [2.00, 57.0] |
| Missing | 55 (83.3%) | 62 (87.3%) | 117 (85.4%) |
UPDRS scores vs. Fluctuation status
##
## Welch Two Sample t-test
##
## data: cc_fluc$updrs_base by cc_fluc$fluc_base
## t = -0.68672, df = 110.94, p-value = 0.4937
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -7.524567 3.651499
## sample estimates:
## mean in group No mean in group Yes
## 27.04918 28.98571##
## Welch Two Sample t-test
##
## data: cc_fluc$updrs_m12 by cc_fluc$fluc_m12
## t = 0.42765, df = 22.416, p-value = 0.673
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -9.434806 14.343378
## sample estimates:
## mean in group No mean in group Yes
## 28.21429 25.76000##
## Welch Two Sample t-test
##
## data: cc_fluc$updrs_m24 by cc_fluc$fluc_m24
## t = -1.2797, df = 19.449, p-value = 0.2157
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -23.512377 5.652237
## sample estimates:
## mean in group No mean in group Yes
## 28.45455 37.38462##
## Welch Two Sample t-test
##
## data: cc_fluc$updrs_m36 by cc_fluc$fluc_m36
## t = -0.91326, df = 2.241, p-value = 0.4485
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -74.48349 46.15016
## sample estimates:
## mean in group No mean in group Yes
## 27.33333 41.50000
MoCA scores vs. Fluctuation status
##
## Welch Two Sample t-test
##
## data: cc_fluc$moca_base by cc_fluc$fluc_base
## t = 2.2136, df = 131.89, p-value = 0.02858
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## 0.2227708 3.9656221
## sample estimates:
## mean in group No mean in group Yes
## 21.26562 19.17143##
## Welch Two Sample t-test
##
## data: cc_fluc$moca_m12 by cc_fluc$fluc_m12
## t = 0.20603, df = 28.385, p-value = 0.8382
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -3.887147 4.757147
## sample estimates:
## mean in group No mean in group Yes
## 18.875 18.440##
## Welch Two Sample t-test
##
## data: cc_fluc$moca_m24 by cc_fluc$fluc_m24
## t = 0.322, df = 20.042, p-value = 0.7508
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -5.394339 7.364036
## sample estimates:
## mean in group No mean in group Yes
## 18.16667 17.18182
CDR vs. Fluctuation status
##
## Welch Two Sample t-test
##
## data: cc_fluc$cdr_base by cc_fluc$fluc_base
## t = -0.6546, df = 70.037, p-value = 0.5149
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -1.8129261 0.9169433
## sample estimates:
## mean in group No mean in group Yes
## 4.661765 5.109756##
## Welch Two Sample t-test
##
## data: cc_fluc$cdr_m12 by cc_fluc$fluc_m12
## t = 0.30801, df = 15.122, p-value = 0.7623
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -2.419817 3.237999
## sample estimates:
## mean in group No mean in group Yes
## 5.909091 5.500000##
## Welch Two Sample t-test
##
## data: cc_fluc$cdr_m24 by cc_fluc$fluc_m24
## t = -0.88223, df = 14.638, p-value = 0.3919
## alternative hypothesis: true difference in means between group No and group Yes is not equal to 0
## 95 percent confidence interval:
## -4.884696 2.029140
## sample estimates:
## mean in group No mean in group Yes
## 5.350000 6.777778
Measuring consistency
## # A tibble: 11 × 5
## # Groups: fluc_base, fluc_m12, fluc_m24 [7]
## fluc_base fluc_m12 fluc_m24 fluc_m36 n
## <chr> <chr> <chr> <chr> <int>
## 1 No No No No 1
## 2 No No No Yes 3
## 3 No No Yes No 1
## 4 No Yes No No 1
## 5 No Yes Yes No 2
## 6 No Yes Yes Yes 3
## 7 Yes No No No 1
## 8 Yes No No Yes 1
## 9 Yes Yes No No 2
## 10 Yes Yes Yes No 1
## 11 Yes Yes Yes Yes 4## # A tibble: 6 × 7
## fluc_base fluc_m12 fluc_m24 fluc_m36 initial final group
## <chr> <chr> <chr> <chr> <dbl> <dbl> <chr>
## 1 Yes Yes No No 1 0 Improvement
## 2 Yes Yes Yes <NA> 1 1 Consistent yes
## 3 No No No <NA> 0 0 Consistent no
## 4 No Yes <NA> <NA> 0 1 Progression
## 5 Yes No No Yes 1 1 Inconsistent
## 6 No No Yes No 0 0 Inconsistent| Overall (N=171) |
|
|---|---|
| Group | |
| Consistent no | 15 (8.8%) |
| Consistent yes | 38 (22.2%) |
| Improvement | 12 (7.0%) |
| Inconsistent | 8 (4.7%) |
| Progression | 18 (10.5%) |
| Missing | 80 (46.8%) |
| Overall (N=91) |
|
|---|---|
| Group | |
| Consistent no | 15 (16.5%) |
| Consistent yes | 38 (41.8%) |
| Improvement | 12 (13.2%) |
| Inconsistent | 8 (8.8%) |
| Progression | 18 (19.8%) |
Spaghetti plots for people who “progressed”
Spaghetti plots for people who “improved”
Spaghetti plots for consistent yes
Attrition
