TEDD Fluctuations
Karl Brown
2024-04-29
TEDD Analysis
Table 1
| AD (N=8) |
DLB (N=11) |
P-value | |
|---|---|---|---|
| Daily activity counts | |||
| Mean (SD) | 1620000 (232000) | 1240000 (473000) | 0.035 |
| Median [Min, Max] | 1620000 [1290000, 1950000] | 1370000 [407000, 1860000] | |
| Day activity | |||
| Mean (SD) | 868000 (160000) | 649000 (264000) | 0.039 |
| Median [Min, Max] | 876000 [657000, 1100000] | 740000 [238000, 931000] | |
| Night activity | |||
| Mean (SD) | 153000 (73300) | 122000 (84400) | 0.407 |
| Median [Min, Max] | 134000 [71700, 305000] | 95500 [29900, 262000] | |
| Drowsy | |||
| No | 5 (62.5%) | 2 (18.2%) | 0.135 |
| Yes | 3 (37.5%) | 9 (81.8%) | |
| Nap | |||
| No | 7 (87.5%) | 5 (45.5%) | 0.163 |
| Yes | 1 (12.5%) | 6 (54.5%) | |
| Illogical | |||
| No | 3 (37.5%) | 0 (0%) | 0.115 |
| Yes | 5 (62.5%) | 11 (100%) | |
| Stare | |||
| No | 6 (75.0%) | 4 (36.4%) | 0.23 |
| Yes | 2 (25.0%) | 7 (63.6%) | |
| Fluctuator | |||
| No | 6 (75.0%) | 2 (18.2%) | 0.045 |
| Yes | 2 (25.0%) | 9 (81.8%) |
Exploratory figures
High intradaily variability may indicate daytime napping and/or nighttime arousals
Values range from 0 to 1, with higher values indicating greater stability
Cleaveland Clinic Analysis
| Overall (N=171) |
|
|---|---|
| AGE_BASELINE | |
| Mean (SD) | 70.3 (6.51) |
| Median [Min, Max] | 70.0 [55.0, 89.0] |
| Missing | 1 (0.6%) |
| GENDER | |
| 1 | 146 (85.4%) |
| 2 | 24 (14.0%) |
| Missing | 1 (0.6%) |
| Baseline MoCA | |
| Mean (SD) | 19.7 (5.69) |
| Median [Min, Max] | 21.0 [6.00, 30.0] |
| Missing | 6 (3.5%) |
| Fluctuator (baseline) | |
| No | 66 (38.6%) |
| Yes | 71 (41.5%) |
| Missing | 34 (19.9%) |
| Fluctuator (month 12) | |
| No | 26 (15.2%) |
| Yes | 53 (31.0%) |
| Missing | 92 (53.8%) |
| Fluctuator (month 24) | |
| No | 20 (11.7%) |
| Yes | 35 (20.5%) |
| Missing | 116 (67.8%) |
| Fluctuator (month 36) | |
| No | 14 (8.2%) |
| Yes | 17 (9.9%) |
| Missing | 140 (81.9%) |
## # A tibble: 11 × 5
## # Groups: fluc_base, fluc_m12, fluc_m24 [7]
## fluc_base fluc_m12 fluc_m24 fluc_m36 n
## <chr> <chr> <chr> <chr> <int>
## 1 No No No No 1
## 2 No No No Yes 3
## 3 No No Yes No 1
## 4 No Yes No No 1
## 5 No Yes Yes No 2
## 6 No Yes Yes Yes 3
## 7 Yes No No No 1
## 8 Yes No No Yes 1
## 9 Yes Yes No No 2
## 10 Yes Yes Yes No 1
## 11 Yes Yes Yes Yes 4