Model_1: lm(log_BMI ~ SEX + AGE + DIABETES + Individual_Geno)

Standard Association Analysis

Anova Table

Summary Table

Paternal Association Analysis

Maternal Association Analysis

Post Hoc Test: TukeyHSD Test for Pairwise Differences Comparison between Heterozygotes

Formally test the difference in effect size between maternally-inherited and paternally-inherited alleles

1st Way: Use Self-Defined Contrast Matrix

2nd Way: Change the reference level as one of the heterozygotes, and re-do the linear model

Model_2: lm(log_BMI ~ SEX + AGE + DIABETES + Indiv_Geno + F_BMI)

Standard Association Analysis

Anova Table

Summary Table

Paternal Association Analysis

Anova Table

Summary Table

Maternal Association Analysis

Anova Table

Summary Table

TukeyHSD Test

Formally test the difference in effect size between maternally-inherited and paternally-inherited alleles

1st Way: Use Self-Defined Contrast Matrix

2nd Way: Change the reference level as one of the heterozygotes, and re-do the linear model

Model_3: lm(log_BMI ~ SEX + AGE + DIABETES + Indiv_Geno + M_BMI)

Standard Association Analysis

Anova Table

Summary Table

Paternal Association Analysis

Anova Table

Summary Table

Maternal Association Analysis

Anova Table

Summary Table

TukeyHSD Test

Formally test the difference in effect size between maternally-inherited and paternally-inherited alleles

1st Way: Use Self-Defined Contrast Matrix

2nd Way: Change the reference level as one of the heterozygotes, and re-do the linear model

Model_4: lm(log_BMI ~ SEX + AGE + DIABETES + Indiv_Geno + F_BMI + M_BMI)

Standard Association Analysis

Anova Table

Summary Table

Paternal Association Analysis

Anova Table

Summary Table

Maternal Association Analysis

Anova Table

Summary Table

TukeyHSD Test

Formally test the difference in effect size between maternally-inherited and paternally-inherited alleles

1st Way: Use Self-Defined Contrast Matrix

2nd Way: Change the reference level as one of the heterozygotes, and re-do the linear model

Model_5: lm(log_BMI ~ SEX + AGE + DIABETES + Indiv_Geno + F_BMI + M_BMI + F_BMI * M_BMI)

Standard Association Analysis

Anova Table

Summary Table

Paternal Association Analysis

Anova Table

Summary Table

Maternal Association Analysis

Anova Table

Summary Table

TukeyHSD Test

Formally test the difference in effect size between maternally-inherited and paternally-inherited alleles

1st Way: Use Self-Defined Contrast Matrix

2nd Way: Change the reference level as one of the heterozygotes, and re-do the linear model

Model_6: lm(log_BMI ~ SEX + AGE + DIABETES + Indiv_Geno + F_BMI + M_BMI + F_BMI * Indiv_Geno + M_BMI * Indiv_Geno)

Standard Association Analysis

Anova Table

Summary Table

Paternal Association

Anova Table

Summary Table

Maternal Association

Anova Table

Summary Table

Formally test the difference in effect size between maternally-inherited and paternally-inherited alleles

1st Way: Use Self-Defined Contrast Matrix

2nd Way: Change the reference level as one of the heterozygotes, and re-do the linear model