| Cohort | Mean Age | Median Age | Minimum Age | Maximum Age | Number of Individuals |
|---|---|---|---|---|---|
| 1 | 70.06 | 71.5 | 50 | 78 | 18 |
| 2 | 71.00 | 73.0 | 59 | 79 | 15 |
| 3 | 69.47 | 72.0 | 54 | 78 | 15 |
| 4 | 70.13 | 71.0 | 56 | 78 | 15 |
| Cohort | Mean Age | Median Age | Minimum Age | Maximum Age | Number of Individuals |
|---|---|---|---|---|---|
| 1 | 70.06 | 71.5 | 50 | 78 | 18 |
| 2 | 71.00 | 73.0 | 59 | 79 | 15 |
| 3 | 69.47 | 72.0 | 54 | 78 | 15 |
| 4 | 70.13 | 71.0 | 56 | 78 | 15 |
| Cohort | Mean Age | Median Age | Minimum Age | Maximum Age | Number of Individuals |
|---|---|---|---|---|---|
| 1 | 70.06 | 71.5 | 50 | 78 | 18 |
| 2 | 71.00 | 73.0 | 59 | 79 | 15 |
| 3 | 69.47 | 72.0 | 54 | 78 | 15 |
| 4 | 70.13 | 71.0 | 56 | 78 | 15 |
| Diabetes Stage | Hypertension Status | Count |
|---|---|---|
| Diabetic | No | 6 |
| Diabetic | Yes | 7 |
| Pre-diabetic | No | 2 |
| Pre-diabetic | Yes | 3 |
| Total | 18 |
| Diabetes Stage | Hypertension Status | Count |
|---|---|---|
| Diabetic | No | 5 |
| Diabetic | Yes | 10 |
| Not diabetic | Yes | 2 |
| Pre-diabetic | No | 2 |
| Pre-diabetic | Yes | 6 |
| Total | 25 |
| Diabetes Stage | Hypertension Status | Count |
|---|---|---|
| Diabetic | No | 8 |
| Not diabetic | Yes | 4 |
| Pre-diabetic | No | 5 |
| Pre-diabetic | Yes | 3 |
| Total | 20 |
| Diabetes Stage | Hypertension Status | Count |
|---|---|---|
| Diabetic | No | 4 |
| Diabetic | Yes | 4 |
| Not diabetic | Yes | 2 |
| Pre-diabetic | No | 5 |
| Pre-diabetic | Yes | 7 |
| Total | 22 |
| Diabetes Stage | Hypertension Status | Count |
|---|---|---|
| Diabetic | No | 23 |
| Diabetic | Yes | 21 |
| Not diabetic | Yes | 8 |
| Pre-diabetic | No | 14 |
| Pre-diabetic | Yes | 19 |
| Total | 85 |
| Diagnostic Cohort | Count |
|---|---|
| Pre-diabetes+Hypertension | 15 |
| Pre-diabetes+No hypertension | 11 |
| Diabetes+Hypertension | 14 |
| Diabetes+No Hypertension | 18 |
| No diabetes+Hypertension | 5 |
| Total | 63 |
## Warning: There was 1 warning in `summarize()`.
## ℹ In argument: `mean_final = mean(as.integer(get(final_var)), na.rm = TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## There was 1 warning in `summarize()`.
## ℹ In argument: `mean_final = mean(as.integer(get(final_var)), na.rm = TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## Warning: There were 2 warnings in `summarize()`.
## The first warning was:
## ℹ In argument: `mean_baseline = mean(as.integer(get(baseline_var)), na.rm =
## TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## ℹ Run `dplyr::last_dplyr_warnings()` to see the 1 remaining warning.
| Cohort | Mean Baseline A1C | Mean Midpoint A1C | Mean Final A1C | Difference (Final - Baseline) A1C |
|---|---|---|---|---|
| Cohort 1 | 6.28 | 6.06 | 6.12 | -0.15 |
| Cohort 2 | 6.14 | 5.80 | 5.93 | -0.21 |
| Cohort 3 | 6.00 | 5.47 | 5.46 | -0.54 |
| Cohort 4 | 6.00 | 5.86 | 5.64 | -0.36 |
| Cohort | Mean Baseline glucose | Mean Midpoint glucose | Mean Final glucose | Difference (Final - Baseline) glucose |
|---|---|---|---|---|
| Cohort 1 | 129.33 | 116.06 | 119.62 | -9.71 |
| Cohort 2 | 110.79 | 108.47 | 113.07 | 2.28 |
| Cohort 3 | 121.00 | 105.27 | 105.64 | -15.36 |
| Cohort 4 | 102.27 | 101.14 | 101.43 | -0.84 |
| Cohort | Mean Baseline weight | Mean Midpoint weight | Mean Final weight | Difference (Final - Baseline) weight |
|---|---|---|---|---|
| Cohort 1 | 151.56 | 145.94 | 140.13 | -11.42 |
| Cohort 2 | 144.55 | 138.86 | 139.69 | -4.85 |
| Cohort 3 | 149.00 | 136.86 | 133.86 | -15.14 |
| Cohort 4 | 160.40 | 155.14 | 153.36 | -7.04 |
| Cohort | Mean Baseline BMI | Mean Midpoint BMI | Mean Final BMI | Difference (Final - Baseline) BMI |
|---|---|---|---|---|
| Cohort 1 | 26.61 | 25.53 | 24.57 | -2.04 |
| Cohort 2 | 26.27 | 25.33 | 25.54 | -0.73 |
| Cohort 3 | 26.93 | 25.57 | 25.00 | -1.93 |
| Cohort 4 | 29.00 | 27.71 | 27.36 | -1.64 |
| Cohort | Mean Baseline cholest | Mean Midpoint cholest | Mean Final cholest | Difference (Final - Baseline) cholest |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 181.50 | 178.60 | 195.83 | 14.33 |
| Cohort 3 | 191.20 | 176.71 | 175.43 | -15.77 |
| Cohort 4 | 179.71 | 162.86 | 184.43 | 4.71 |
| Cohort | Mean Baseline LDL | Mean Midpoint LDL | Mean Final LDL | Difference (Final - Baseline) LDL |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 100.57 | 98.47 | 110.08 | 9.51 |
| Cohort 3 | 110.73 | 105.20 | 99.71 | -11.02 |
| Cohort 4 | 105.40 | 89.64 | 107.50 | 2.10 |
| Cohort | Mean Baseline HDL | Mean Midpoint HDL | Mean Final HDL | Difference (Final - Baseline) HDL |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 59.69 | 59.33 | 60.31 | 0.62 |
| Cohort 3 | 54.07 | 54.47 | 54.71 | 0.65 |
| Cohort 4 | 54.53 | 52.64 | 57.50 | 2.97 |
## Warning: There was 1 warning in `summarize()`.
## ℹ In argument: `mean_final = mean(as.integer(get(final_var)), na.rm = TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## Warning: There was 1 warning in `summarize()`.
## ℹ In argument: `mean_final = mean(as.integer(get(final_var)), na.rm = TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## Warning: There were 2 warnings in `summarize()`.
## The first warning was:
## ℹ In argument: `mean_baseline = mean(as.integer(get(baseline_var)), na.rm =
## TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## ℹ Run `dplyr::last_dplyr_warnings()` to see the 1 remaining warning.
| Cohort | Mean Baseline A1C | Mean Midpoint A1C | Mean Final A1C | Difference (Final - Baseline) A1C |
|---|---|---|---|---|
| Cohort 1 | 6.28 | 6.06 | 6.12 | -0.15 |
| Cohort 2 | 6.14 | 5.80 | 5.93 | -0.21 |
| Cohort 3 | 6.00 | 5.47 | 5.46 | -0.54 |
| Cohort 4 | 6.00 | 5.86 | 5.64 | -0.36 |
| Cohort | Mean Baseline glucose | Mean Midpoint glucose | Mean Final glucose | Difference (Final - Baseline) glucose |
|---|---|---|---|---|
| Cohort 1 | 129.33 | 116.06 | 119.62 | -9.71 |
| Cohort 2 | 110.79 | 108.47 | 113.07 | 2.28 |
| Cohort 3 | 121.00 | 105.27 | 105.64 | -15.36 |
| Cohort 4 | 102.27 | 101.14 | 101.43 | -0.84 |
| Cohort | Mean Baseline weight | Mean Midpoint weight | Mean Final weight | Difference (Final - Baseline) weight |
|---|---|---|---|---|
| Cohort 1 | 151.56 | 145.94 | 140.13 | -11.42 |
| Cohort 2 | 144.55 | 138.86 | 139.69 | -4.85 |
| Cohort 3 | 149.00 | 136.86 | 133.86 | -15.14 |
| Cohort 4 | 160.40 | 155.14 | 153.36 | -7.04 |
| Cohort | Mean Baseline BMI | Mean Midpoint BMI | Mean Final BMI | Difference (Final - Baseline) BMI |
|---|---|---|---|---|
| Cohort 1 | 26.61 | 25.53 | 24.57 | -2.04 |
| Cohort 2 | 26.27 | 25.33 | 25.54 | -0.73 |
| Cohort 3 | 26.93 | 25.57 | 25.00 | -1.93 |
| Cohort 4 | 29.00 | 27.71 | 27.36 | -1.64 |
| Cohort | Mean Baseline cholest | Mean Midpoint cholest | Mean Final cholest | Difference (Final - Baseline) cholest |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 181.50 | 178.60 | 195.83 | 14.33 |
| Cohort 3 | 191.20 | 176.71 | 175.43 | -15.77 |
| Cohort 4 | 179.71 | 162.86 | 184.43 | 4.71 |
| Cohort | Mean Baseline LDL | Mean Midpoint LDL | Mean Final LDL | Difference (Final - Baseline) LDL |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 100.57 | 98.47 | 110.08 | 9.51 |
| Cohort 3 | 110.73 | 105.20 | 99.71 | -11.02 |
| Cohort 4 | 105.40 | 89.64 | 107.50 | 2.10 |
| Cohort | Mean Baseline HDL | Mean Midpoint HDL | Mean Final HDL | Difference (Final - Baseline) HDL |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 59.69 | 59.33 | 60.31 | 0.62 |
| Cohort 3 | 54.07 | 54.47 | 54.71 | 0.65 |
| Cohort 4 | 54.53 | 52.64 | 57.50 | 2.97 |
## Warning: There was 1 warning in `summarize()`.
## ℹ In argument: `mean_final = mean(as.integer(get(final_var)), na.rm = TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## Warning: There was 1 warning in `summarize()`.
## ℹ In argument: `mean_final = mean(as.integer(get(final_var)), na.rm = TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## Warning: There were 2 warnings in `summarize()`.
## The first warning was:
## ℹ In argument: `mean_baseline = mean(as.integer(get(baseline_var)), na.rm =
## TRUE)`.
## Caused by warning in `mean()`:
## ! NAs introduced by coercion
## ℹ Run `dplyr::last_dplyr_warnings()` to see the 1 remaining warning.
| Cohort | Mean Baseline A1C | Mean Midpoint A1C | Mean Final A1C | Difference (Final - Baseline) A1C |
|---|---|---|---|---|
| Cohort 1 | 6.28 | 6.06 | 6.12 | -0.15 |
| Cohort 2 | 6.14 | 5.80 | 5.93 | -0.21 |
| Cohort 3 | 6.00 | 5.47 | 5.46 | -0.54 |
| Cohort 4 | 6.00 | 5.86 | 5.64 | -0.36 |
| Cohort | Mean Baseline glucose | Mean Midpoint glucose | Mean Final glucose | Difference (Final - Baseline) glucose |
|---|---|---|---|---|
| Cohort 1 | 129.33 | 116.06 | 119.62 | -9.71 |
| Cohort 2 | 110.79 | 108.47 | 113.07 | 2.28 |
| Cohort 3 | 121.00 | 105.27 | 105.64 | -15.36 |
| Cohort 4 | 102.27 | 101.14 | 101.43 | -0.84 |
| Cohort | Mean Baseline weight | Mean Midpoint weight | Mean Final weight | Difference (Final - Baseline) weight |
|---|---|---|---|---|
| Cohort 1 | 151.56 | 145.94 | 140.13 | -11.42 |
| Cohort 2 | 144.55 | 138.86 | 139.69 | -4.85 |
| Cohort 3 | 149.00 | 136.86 | 133.86 | -15.14 |
| Cohort 4 | 160.40 | 155.14 | 153.36 | -7.04 |
| Cohort | Mean Baseline BMI | Mean Midpoint BMI | Mean Final BMI | Difference (Final - Baseline) BMI |
|---|---|---|---|---|
| Cohort 1 | 26.61 | 25.53 | 24.57 | -2.04 |
| Cohort 2 | 26.27 | 25.33 | 25.54 | -0.73 |
| Cohort 3 | 26.93 | 25.57 | 25.00 | -1.93 |
| Cohort 4 | 29.00 | 27.71 | 27.36 | -1.64 |
| Cohort | Mean Baseline cholest | Mean Midpoint cholest | Mean Final cholest | Difference (Final - Baseline) cholest |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 181.50 | 178.60 | 195.83 | 14.33 |
| Cohort 3 | 191.20 | 176.71 | 175.43 | -15.77 |
| Cohort 4 | 179.71 | 162.86 | 184.43 | 4.71 |
| Cohort | Mean Baseline LDL | Mean Midpoint LDL | Mean Final LDL | Difference (Final - Baseline) LDL |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 100.57 | 98.47 | 110.08 | 9.51 |
| Cohort 3 | 110.73 | 105.20 | 99.71 | -11.02 |
| Cohort 4 | 105.40 | 89.64 | 107.50 | 2.10 |
| Cohort | Mean Baseline HDL | Mean Midpoint HDL | Mean Final HDL | Difference (Final - Baseline) HDL |
|---|---|---|---|---|
| Cohort 1 | NaN | NaN | NaN | NaN |
| Cohort 2 | 59.69 | 59.33 | 60.31 | 0.62 |
| Cohort 3 | 54.07 | 54.47 | 54.71 | 0.65 |
| Cohort 4 | 54.53 | 52.64 | 57.50 | 2.97 |
| Metric | Cohort | Diagnostic Cohort | Total (N) | Mean Baseline | Mean Midpoint | Mean Final | Difference (Final - Baseline) |
|---|---|---|---|---|---|---|---|
| A1C | 1 | Pre-diabetes+Hypertension | 3 | 6.00 | 5.93 | 5.97 | -0.03 |
| A1C | 1 | Pre-diabetes+No hypertension | 2 | 6.05 | 5.80 | 5.95 | -0.10 |
| A1C | 1 | Diabetes+Hypertension | 7 | 7.03 | 6.73 | 6.63 | -0.40 |
| A1C | 1 | Diabetes+No Hypertension | 6 | 7.32 | 6.90 | 6.86 | -0.46 |
| A1C | 2 | Pre-diabetes+Hypertension | 3 | 6.20 | 5.90 | 6.00 | -0.20 |
| A1C | 2 | Pre-diabetes+No hypertension | 1 | 6.10 | 6.00 | 6.00 | -0.10 |
| A1C | 2 | Diabetes+Hypertension | 6 | 6.50 | 6.58 | 6.67 | 0.17 |
| A1C | 2 | Diabetes+No Hypertension | 4 | 7.08 | 6.42 | 6.55 | -0.53 |
| A1C | 2 | No diabetes+Hypertension | 1 | 5.30 | 5.60 | 5.60 | 0.30 |
| A1C | 3 | Pre-diabetes+Hypertension | 3 | 5.97 | 5.83 | 5.90 | -0.07 |
| A1C | 3 | Pre-diabetes+No hypertension | 4 | 5.68 | 5.60 | 5.72 | 0.05 |
| A1C | 3 | Diabetes+No Hypertension | 5 | 7.78 | 6.74 | 6.67 | -1.11 |
| A1C | 3 | No diabetes+Hypertension | 3 | 5.50 | 5.63 | 5.63 | 0.13 |
| A1C | 4 | Pre-diabetes+Hypertension | 6 | 6.07 | 6.04 | 5.95 | -0.12 |
| A1C | 4 | Pre-diabetes+No hypertension | 4 | 5.95 | 5.92 | 5.88 | -0.08 |
| A1C | 4 | Diabetes+Hypertension | 1 | 7.70 | 6.60 | 6.50 | -1.20 |
| A1C | 4 | Diabetes+No Hypertension | 3 | 7.37 | 7.17 | 7.40 | 0.03 |
| A1C | 4 | No diabetes+Hypertension | 1 | 5.50 | 5.50 | 5.40 | -0.10 |
| glucose | 1 | Pre-diabetes+Hypertension | 3 | 105.33 | 98.00 | 100.00 | -5.33 |
| glucose | 1 | Pre-diabetes+No hypertension | 2 | 115.50 | 97.00 | 97.50 | -18.00 |
| glucose | 1 | Diabetes+Hypertension | 7 | 135.43 | 110.14 | 123.83 | -11.60 |
| glucose | 1 | Diabetes+No Hypertension | 6 | 138.83 | 142.80 | 135.20 | -3.63 |
| glucose | 2 | Pre-diabetes+Hypertension | 3 | 94.00 | 99.67 | 113.67 | 19.67 |
| glucose | 2 | Pre-diabetes+No hypertension | 1 | 98.00 | 92.00 | 100.00 | 2.00 |
| glucose | 2 | Diabetes+Hypertension | 6 | 112.17 | 116.67 | 115.00 | 2.83 |
| glucose | 2 | Diabetes+No Hypertension | 4 | 125.75 | 111.25 | 118.00 | -7.75 |
| glucose | 2 | No diabetes+Hypertension | 1 | 89.00 | 91.00 | 93.00 | 4.00 |
| glucose | 3 | Pre-diabetes+Hypertension | 3 | 102.00 | 95.00 | 94.67 | -7.33 |
| glucose | 3 | Pre-diabetes+No hypertension | 4 | 108.50 | 96.50 | 96.75 | -11.75 |
| glucose | 3 | Diabetes+No Hypertension | 5 | 157.80 | 120.22 | 132.75 | -25.05 |
| glucose | 3 | No diabetes+Hypertension | 3 | 95.33 | 102.33 | 92.33 | -3.00 |
| glucose | 4 | Pre-diabetes+Hypertension | 6 | 101.50 | 104.00 | 98.00 | -3.50 |
| glucose | 4 | Pre-diabetes+No hypertension | 4 | 88.75 | 97.50 | 93.50 | 4.75 |
| glucose | 4 | Diabetes+Hypertension | 1 | 133.00 | 119.00 | 107.00 | -26.00 |
| glucose | 4 | Diabetes+No Hypertension | 3 | 112.67 | 98.00 | 127.50 | 14.83 |
| glucose | 4 | No diabetes+Hypertension | 1 | 99.00 | 93.00 | 96.00 | -3.00 |
| weight | 1 | Pre-diabetes+Hypertension | 3 | 173.67 | 170.00 | 165.33 | -8.33 |
| weight | 1 | Pre-diabetes+No hypertension | 2 | 153.00 | 141.00 | 131.00 | -22.00 |
| weight | 1 | Diabetes+Hypertension | 7 | 136.29 | 132.21 | 118.80 | -17.49 |
| weight | 1 | Diabetes+No Hypertension | 6 | 157.83 | 152.80 | 150.00 | -7.83 |
| weight | 2 | Pre-diabetes+Hypertension | 3 | 186.00 | 176.67 | 177.00 | -9.00 |
| weight | 2 | Pre-diabetes+No hypertension | 1 | 113.00 | 117.00 | 119.00 | 6.00 |
| weight | 2 | Diabetes+Hypertension | 6 | 138.50 | 137.33 | 136.22 | -2.28 |
| weight | 2 | Diabetes+No Hypertension | 4 | 154.33 | 130.00 | 132.50 | -21.83 |
| weight | 2 | No diabetes+Hypertension | 1 | 88.00 | 83.00 | 84.00 | -4.00 |
| weight | 3 | Pre-diabetes+Hypertension | 3 | 144.80 | 137.67 | 132.83 | -11.97 |
| weight | 3 | Pre-diabetes+No hypertension | 4 | 148.25 | 139.00 | 139.25 | -9.00 |
| weight | 3 | Diabetes+No Hypertension | 5 | 152.38 | 129.50 | 126.50 | -25.88 |
| weight | 3 | No diabetes+Hypertension | 3 | 150.13 | 143.17 | 137.67 | -12.47 |
| weight | 4 | Pre-diabetes+Hypertension | 6 | 149.45 | 146.51 | 143.23 | -6.22 |
| weight | 4 | Pre-diabetes+No hypertension | 4 | 161.00 | 155.50 | 154.15 | -6.85 |
| weight | 4 | Diabetes+Hypertension | 1 | 233.00 | 218.00 | 218.00 | -15.00 |
| weight | 4 | Diabetes+No Hypertension | 3 | 152.33 | 148.67 | 152.00 | -0.33 |
| weight | 4 | No diabetes+Hypertension | 1 | 176.00 | 154.00 | 150.00 | -26.00 |
| BMI | 1 | Pre-diabetes+Hypertension | 3 | 29.54 | 28.51 | 27.64 | -1.90 |
| BMI | 1 | Pre-diabetes+No hypertension | 2 | 26.91 | 23.44 | 22.67 | -4.23 |
| BMI | 1 | Diabetes+Hypertension | 7 | 26.09 | 25.24 | 23.22 | -2.87 |
| BMI | 1 | Diabetes+No Hypertension | 6 | 27.27 | 26.36 | 26.34 | -0.93 |
| BMI | 2 | Pre-diabetes+Hypertension | 3 | 31.95 | 30.04 | 30.82 | -1.14 |
| BMI | 2 | Pre-diabetes+No hypertension | 1 | 23.62 | 24.04 | 24.03 | 0.41 |
| BMI | 2 | Diabetes+Hypertension | 6 | 24.26 | 25.70 | 24.86 | 0.60 |
| BMI | 2 | Diabetes+No Hypertension | 4 | 29.79 | 22.95 | 25.67 | -4.12 |
| BMI | 2 | No diabetes+Hypertension | 1 | 20.00 | 19.65 | 19.88 | -0.12 |
| BMI | 3 | Pre-diabetes+Hypertension | 3 | 27.38 | 26.52 | 25.56 | -1.82 |
| BMI | 3 | Pre-diabetes+No hypertension | 4 | 28.29 | 26.64 | 26.31 | -1.98 |
| BMI | 3 | Diabetes+No Hypertension | 5 | 26.94 | 24.34 | 24.17 | -2.77 |
| BMI | 3 | No diabetes+Hypertension | 3 | 27.97 | 26.97 | 26.01 | -1.96 |
| BMI | 4 | Pre-diabetes+Hypertension | 6 | 28.60 | 27.73 | 26.74 | -1.86 |
| BMI | 4 | Pre-diabetes+No hypertension | 4 | 26.76 | 25.41 | 25.10 | -1.66 |
| BMI | 4 | Diabetes+Hypertension | 1 | 40.88 | 39.30 | 39.30 | -1.58 |
| BMI | 4 | Diabetes+No Hypertension | 3 | 29.61 | 28.49 | 29.75 | 0.14 |
| BMI | 4 | No diabetes+Hypertension | 1 | 34.75 | 29.09 | 28.30 | -6.45 |
| cholest | 1 | Pre-diabetes+Hypertension | 3 | NaN | NaN | NaN | NaN |
| cholest | 1 | Pre-diabetes+No hypertension | 2 | NaN | NaN | NaN | NaN |
| cholest | 1 | Diabetes+Hypertension | 7 | NaN | NaN | NaN | NaN |
| cholest | 1 | Diabetes+No Hypertension | 6 | NaN | NaN | NaN | NaN |
| cholest | 2 | Pre-diabetes+Hypertension | 3 | 213.00 | 204.67 | 228.33 | 15.33 |
| cholest | 2 | Pre-diabetes+No hypertension | 1 | 156.00 | 157.00 | 160.00 | 4.00 |
| cholest | 2 | Diabetes+Hypertension | 6 | 175.50 | 178.00 | 190.25 | 14.75 |
| cholest | 2 | Diabetes+No Hypertension | 4 | 170.75 | 148.75 | 174.67 | 3.92 |
| cholest | 2 | No diabetes+Hypertension | 1 | 223.00 | 245.00 | 220.00 | -3.00 |
| cholest | 3 | Pre-diabetes+Hypertension | 3 | 188.67 | 178.67 | 170.00 | -18.67 |
| cholest | 3 | Pre-diabetes+No hypertension | 4 | 223.00 | 190.00 | 187.50 | -35.50 |
| cholest | 3 | Diabetes+No Hypertension | 5 | 189.80 | 173.40 | 161.00 | -28.80 |
| cholest | 3 | No diabetes+Hypertension | 3 | 153.67 | 167.00 | 184.00 | 30.33 |
| cholest | 4 | Pre-diabetes+Hypertension | 6 | 174.50 | 155.60 | 188.67 | 14.17 |
| cholest | 4 | Pre-diabetes+No hypertension | 4 | 170.50 | 169.00 | 177.25 | 6.75 |
| cholest | 4 | Diabetes+Hypertension | 1 | 212.00 | 166.00 | 186.00 | -26.00 |
| cholest | 4 | Diabetes+No Hypertension | 3 | 145.00 | 146.00 | 155.50 | 10.50 |
| cholest | 4 | No diabetes+Hypertension | 1 | 285.00 | 222.00 | 244.00 | -41.00 |
| LDL | 1 | Pre-diabetes+Hypertension | 3 | NaN | NaN | NaN | NaN |
| LDL | 1 | Pre-diabetes+No hypertension | 2 | NaN | NaN | NaN | NaN |
| LDL | 1 | Diabetes+Hypertension | 7 | NaN | NaN | NaN | NaN |
| LDL | 1 | Diabetes+No Hypertension | 6 | NaN | NaN | NaN | NaN |
| LDL | 2 | Pre-diabetes+Hypertension | 3 | 135.00 | 131.00 | 142.67 | 7.67 |
| LDL | 2 | Pre-diabetes+No hypertension | 1 | 92.00 | 93.00 | 91.00 | -1.00 |
| LDL | 2 | Diabetes+Hypertension | 6 | 91.50 | 92.83 | 101.80 | 10.30 |
| LDL | 2 | Diabetes+No Hypertension | 4 | 97.00 | 78.75 | 102.67 | 5.67 |
| LDL | 2 | No diabetes+Hypertension | 1 | 109.00 | 119.00 | 95.00 | -14.00 |
| LDL | 3 | Pre-diabetes+Hypertension | 3 | 105.00 | 104.50 | 91.60 | -13.40 |
| LDL | 3 | Pre-diabetes+No hypertension | 4 | 138.50 | 127.00 | 110.50 | -28.00 |
| LDL | 3 | Diabetes+No Hypertension | 5 | 112.80 | 98.08 | 86.75 | -26.05 |
| LDL | 3 | No diabetes+Hypertension | 3 | 76.00 | 89.00 | 111.00 | 35.00 |
| LDL | 4 | Pre-diabetes+Hypertension | 6 | 101.50 | 82.80 | 108.17 | 6.67 |
| LDL | 4 | Pre-diabetes+No hypertension | 4 | 105.00 | 100.50 | 107.75 | 2.75 |
| LDL | 4 | Diabetes+Hypertension | 1 | 122.00 | 88.00 | 118.00 | -4.00 |
| LDL | 4 | Diabetes+No Hypertension | 3 | 80.00 | 68.00 | 72.00 | -8.00 |
| LDL | 4 | No diabetes+Hypertension | 1 | 190.00 | 147.00 | 163.00 | -27.00 |
| HDL | 1 | Pre-diabetes+Hypertension | 3 | NaN | NaN | NaN | NaN |
| HDL | 1 | Pre-diabetes+No hypertension | 2 | NaN | NaN | NaN | NaN |
| HDL | 1 | Diabetes+Hypertension | 7 | NaN | NaN | NaN | NaN |
| HDL | 1 | Diabetes+No Hypertension | 6 | NaN | NaN | NaN | NaN |
| HDL | 2 | Pre-diabetes+Hypertension | 3 | 48.00 | 44.00 | 50.00 | 2.00 |
| HDL | 2 | Pre-diabetes+No hypertension | 1 | 51.00 | 50.00 | 52.00 | 1.00 |
| HDL | 2 | Diabetes+Hypertension | 6 | 60.28 | 65.00 | 62.20 | 1.92 |
| HDL | 2 | Diabetes+No Hypertension | 4 | 55.67 | 51.50 | 52.67 | -3.00 |
| HDL | 2 | No diabetes+Hypertension | 1 | 101.00 | 112.00 | 113.00 | 12.00 |
| HDL | 3 | Pre-diabetes+Hypertension | 3 | 65.67 | 59.77 | 60.80 | -4.87 |
| HDL | 3 | Pre-diabetes+No hypertension | 4 | 53.50 | 54.50 | 57.75 | 4.25 |
| HDL | 3 | Diabetes+No Hypertension | 5 | 43.60 | 46.38 | 44.25 | 0.65 |
| HDL | 3 | No diabetes+Hypertension | 3 | 60.67 | 63.00 | 58.67 | -2.00 |
| HDL | 4 | Pre-diabetes+Hypertension | 6 | 55.50 | 52.40 | 62.00 | 6.50 |
| HDL | 4 | Pre-diabetes+No hypertension | 4 | 50.75 | 50.75 | 51.50 | 0.75 |
| HDL | 4 | Diabetes+Hypertension | 1 | 53.00 | 46.00 | 40.00 | -13.00 |
| HDL | 4 | Diabetes+No Hypertension | 3 | 55.57 | 58.63 | 66.00 | 10.43 |
| HDL | 4 | No diabetes+Hypertension | 1 | 63.00 | 51.00 | 55.00 | -8.00 |
| Metric | Cohort | Diagnostic Cohort | Total (N) | Mean Baseline | Mean Midpoint | Mean Final | Difference (Final - Baseline) |
|---|---|---|---|---|---|---|---|
| A1C | 1 | Diabetes | 13 | 7.16 | 6.80 | 6.74 | -0.43 |
| A1C | 1 | Pre-diabetes | 5 | 6.02 | 5.88 | 5.96 | -0.06 |
| A1C | 2 | Diabetes | 10 | 6.73 | 6.52 | 6.62 | -0.11 |
| A1C | 2 | Pre-diabetes | 4 | 6.17 | 5.92 | 6.00 | -0.17 |
| A1C | 2 | No diabetes | 1 | 5.30 | 5.60 | 5.60 | 0.30 |
| A1C | 3 | Diabetes | 5 | 7.78 | 6.74 | 6.67 | -1.11 |
| A1C | 3 | Pre-diabetes | 7 | 5.80 | 5.70 | 5.80 | 0.00 |
| A1C | 3 | No diabetes | 3 | 5.50 | 5.63 | 5.63 | 0.13 |
| A1C | 4 | Diabetes | 4 | 7.45 | 7.03 | 7.10 | -0.35 |
| A1C | 4 | Pre-diabetes | 10 | 6.02 | 5.99 | 5.92 | -0.10 |
| A1C | 4 | No diabetes | 1 | 5.50 | 5.50 | 5.40 | -0.10 |
| glucose | 1 | Diabetes | 13 | 137.00 | 123.75 | 129.00 | -8.00 |
| glucose | 1 | Pre-diabetes | 5 | 109.40 | 97.60 | 99.00 | -10.40 |
| glucose | 2 | Diabetes | 10 | 117.60 | 114.50 | 116.20 | -1.40 |
| glucose | 2 | Pre-diabetes | 4 | 95.33 | 97.75 | 110.25 | 14.92 |
| glucose | 2 | No diabetes | 1 | 89.00 | 91.00 | 93.00 | 4.00 |
| glucose | 3 | Diabetes | 5 | 157.80 | 120.22 | 132.75 | -25.05 |
| glucose | 3 | Pre-diabetes | 7 | 105.71 | 95.86 | 95.86 | -9.86 |
| glucose | 3 | No diabetes | 3 | 95.33 | 102.33 | 92.33 | -3.00 |
| glucose | 4 | Diabetes | 4 | 117.75 | 103.25 | 120.67 | 2.92 |
| glucose | 4 | Pre-diabetes | 10 | 96.40 | 101.11 | 96.20 | -0.20 |
| glucose | 4 | No diabetes | 1 | 99.00 | 93.00 | 96.00 | -3.00 |
| weight | 1 | Diabetes | 13 | 146.23 | 140.79 | 134.40 | -11.83 |
| weight | 1 | Pre-diabetes | 5 | 165.40 | 158.40 | 151.60 | -13.80 |
| weight | 2 | Diabetes | 10 | 145.29 | 134.89 | 135.29 | -10.00 |
| weight | 2 | Pre-diabetes | 4 | 161.67 | 161.75 | 162.50 | 0.83 |
| weight | 2 | No diabetes | 1 | 88.00 | 83.00 | 84.00 | -4.00 |
| weight | 3 | Diabetes | 5 | 152.38 | 129.50 | 126.50 | -25.88 |
| weight | 3 | Pre-diabetes | 7 | 146.77 | 138.43 | 136.50 | -10.27 |
| weight | 3 | No diabetes | 3 | 150.13 | 143.17 | 137.67 | -12.47 |
| weight | 4 | Diabetes | 4 | 172.50 | 166.00 | 174.00 | 1.50 |
| weight | 4 | Pre-diabetes | 10 | 154.07 | 150.51 | 147.60 | -6.47 |
| weight | 4 | No diabetes | 1 | 176.00 | 154.00 | 150.00 | -26.00 |
| BMI | 1 | Diabetes | 13 | 26.63 | 25.71 | 24.61 | -2.02 |
| BMI | 1 | Pre-diabetes | 5 | 28.49 | 26.49 | 25.66 | -2.83 |
| BMI | 2 | Diabetes | 10 | 26.63 | 24.91 | 25.06 | -1.57 |
| BMI | 2 | Pre-diabetes | 4 | 29.18 | 28.54 | 29.12 | -0.06 |
| BMI | 2 | No diabetes | 1 | 20.00 | 19.65 | 19.88 | -0.12 |
| BMI | 3 | Diabetes | 5 | 26.94 | 24.34 | 24.17 | -2.77 |
| BMI | 3 | Pre-diabetes | 7 | 27.90 | 26.59 | 25.99 | -1.91 |
| BMI | 3 | No diabetes | 3 | 27.97 | 26.97 | 26.01 | -1.96 |
| BMI | 4 | Diabetes | 4 | 32.43 | 31.19 | 32.93 | 0.51 |
| BMI | 4 | Pre-diabetes | 10 | 27.86 | 26.70 | 26.08 | -1.78 |
| BMI | 4 | No diabetes | 1 | 34.75 | 29.09 | 28.30 | -6.45 |
| cholest | 1 | Diabetes | 13 | NaN | NaN | NaN | NaN |
| cholest | 1 | Pre-diabetes | 5 | NaN | NaN | NaN | NaN |
| cholest | 2 | Diabetes | 10 | 173.60 | 166.30 | 183.57 | 9.97 |
| cholest | 2 | Pre-diabetes | 4 | 194.00 | 192.75 | 211.25 | 17.25 |
| cholest | 2 | No diabetes | 1 | 223.00 | 245.00 | 220.00 | -3.00 |
| cholest | 3 | Diabetes | 5 | 189.80 | 173.40 | 161.00 | -28.80 |
| cholest | 3 | Pre-diabetes | 7 | 208.29 | 184.33 | 180.00 | -28.29 |
| cholest | 3 | No diabetes | 3 | 153.67 | 167.00 | 184.00 | 30.33 |
| cholest | 4 | Diabetes | 4 | 167.33 | 151.00 | 165.67 | -1.67 |
| cholest | 4 | Pre-diabetes | 10 | 172.90 | 161.56 | 184.10 | 11.20 |
| cholest | 4 | No diabetes | 1 | 285.00 | 222.00 | 244.00 | -41.00 |
| LDL | 1 | Diabetes | 13 | NaN | NaN | NaN | NaN |
| LDL | 1 | Pre-diabetes | 5 | NaN | NaN | NaN | NaN |
| LDL | 2 | Diabetes | 10 | 93.70 | 87.20 | 102.12 | 8.42 |
| LDL | 2 | Pre-diabetes | 4 | 120.67 | 121.50 | 129.75 | 9.08 |
| LDL | 2 | No diabetes | 1 | 109.00 | 119.00 | 95.00 | -14.00 |
| LDL | 3 | Diabetes | 5 | 112.80 | 98.08 | 86.75 | -26.05 |
| LDL | 3 | Pre-diabetes | 7 | 124.14 | 117.36 | 102.40 | -21.74 |
| LDL | 3 | No diabetes | 3 | 76.00 | 89.00 | 111.00 | 35.00 |
| LDL | 4 | Diabetes | 4 | 90.50 | 73.00 | 87.33 | -3.17 |
| LDL | 4 | Pre-diabetes | 10 | 102.90 | 90.67 | 108.00 | 5.10 |
| LDL | 4 | No diabetes | 1 | 190.00 | 147.00 | 163.00 | -27.00 |
| HDL | 1 | Diabetes | 13 | NaN | NaN | NaN | NaN |
| HDL | 1 | Pre-diabetes | 5 | NaN | NaN | NaN | NaN |
| HDL | 2 | Diabetes | 10 | 58.74 | 59.60 | 58.62 | -0.12 |
| HDL | 2 | Pre-diabetes | 4 | 49.00 | 45.50 | 50.50 | 1.50 |
| HDL | 2 | No diabetes | 1 | 101.00 | 112.00 | 113.00 | 12.00 |
| HDL | 3 | Diabetes | 5 | 43.60 | 46.38 | 44.25 | 0.65 |
| HDL | 3 | Pre-diabetes | 7 | 58.71 | 56.76 | 59.06 | 0.34 |
| HDL | 3 | No diabetes | 3 | 60.67 | 63.00 | 58.67 | -2.00 |
| HDL | 4 | Diabetes | 4 | 54.92 | 55.48 | 57.33 | 2.41 |
| HDL | 4 | Pre-diabetes | 10 | 53.60 | 51.67 | 57.80 | 4.20 |
| HDL | 4 | No diabetes | 1 | 63.00 | 51.00 | 55.00 | -8.00 |
| Metric | Cohort | Diagnostic Cohort | Total (N) | Mean Baseline | Mean Midpoint | Mean Final | Difference (Final - Baseline) |
|---|---|---|---|---|---|---|---|
| A1C | 1 | Hypertension | 10 | 6.72 | 6.49 | 6.41 | -0.31 |
| A1C | 1 | No hypertension | 8 | 7.00 | 6.59 | 6.60 | -0.40 |
| A1C | 2 | Hypertension | 10 | 6.30 | 6.28 | 6.36 | 0.06 |
| A1C | 2 | No hypertension | 5 | 6.88 | 6.34 | 6.44 | -0.44 |
| A1C | 3 | Hypertension | 6 | 5.78 | 5.73 | 5.77 | -0.01 |
| A1C | 3 | No hypertension | 9 | 6.84 | 6.23 | 6.13 | -0.72 |
| A1C | 4 | Hypertension | 8 | 6.20 | 6.04 | 5.95 | -0.25 |
| A1C | 4 | No hypertension | 7 | 6.56 | 6.46 | 6.38 | -0.17 |
| glucose | 1 | Hypertension | 10 | 126.40 | 106.50 | 115.89 | -10.51 |
| glucose | 1 | No hypertension | 8 | 133.00 | 129.71 | 124.43 | -8.57 |
| glucose | 2 | Hypertension | 10 | 105.56 | 109.00 | 112.40 | 6.84 |
| glucose | 2 | No hypertension | 5 | 120.20 | 107.40 | 114.40 | -5.80 |
| glucose | 3 | Hypertension | 6 | 98.67 | 98.67 | 93.50 | -5.17 |
| glucose | 3 | No hypertension | 9 | 135.89 | 109.68 | 114.75 | -21.14 |
| glucose | 4 | Hypertension | 8 | 105.12 | 104.57 | 98.88 | -6.25 |
| glucose | 4 | No hypertension | 7 | 99.00 | 97.71 | 104.83 | 5.83 |
| weight | 1 | Hypertension | 10 | 147.50 | 143.55 | 136.25 | -11.25 |
| weight | 1 | No hypertension | 8 | 156.62 | 149.43 | 144.57 | -12.05 |
| weight | 2 | Hypertension | 10 | 144.86 | 143.70 | 143.23 | -1.63 |
| weight | 2 | No hypertension | 5 | 144.00 | 126.75 | 128.00 | -16.00 |
| weight | 3 | Hypertension | 6 | 147.47 | 140.42 | 135.25 | -12.22 |
| weight | 3 | No hypertension | 9 | 150.54 | 134.25 | 132.88 | -17.67 |
| weight | 4 | Hypertension | 8 | 163.21 | 157.79 | 153.43 | -9.79 |
| weight | 4 | No hypertension | 7 | 157.29 | 152.57 | 153.43 | -3.85 |
| BMI | 1 | Hypertension | 10 | 27.12 | 26.22 | 24.88 | -2.24 |
| BMI | 1 | No hypertension | 8 | 27.18 | 25.53 | 25.12 | -2.06 |
| BMI | 2 | Hypertension | 10 | 25.85 | 26.47 | 26.15 | 0.30 |
| BMI | 2 | No hypertension | 5 | 28.25 | 23.32 | 25.12 | -3.13 |
| BMI | 3 | Hypertension | 6 | 27.67 | 26.74 | 25.78 | -1.89 |
| BMI | 3 | No hypertension | 9 | 27.62 | 25.49 | 25.24 | -2.38 |
| BMI | 4 | Hypertension | 8 | 30.90 | 29.57 | 28.50 | -2.40 |
| BMI | 4 | No hypertension | 7 | 27.98 | 26.73 | 26.65 | -1.33 |
| cholest | 1 | Hypertension | 10 | NaN | NaN | NaN | NaN |
| cholest | 1 | No hypertension | 8 | NaN | NaN | NaN | NaN |
| cholest | 2 | Hypertension | 10 | 189.11 | 192.70 | 208.25 | 19.14 |
| cholest | 2 | No hypertension | 5 | 167.80 | 150.40 | 171.00 | 3.20 |
| cholest | 3 | Hypertension | 6 | 171.17 | 172.83 | 177.00 | 5.83 |
| cholest | 3 | No hypertension | 9 | 204.56 | 179.62 | 174.25 | -30.31 |
| cholest | 4 | Hypertension | 8 | 193.00 | 166.57 | 195.25 | 2.25 |
| cholest | 4 | No hypertension | 7 | 162.00 | 159.14 | 170.00 | 8.00 |
| LDL | 1 | Hypertension | 10 | NaN | NaN | NaN | NaN |
| LDL | 1 | No hypertension | 8 | NaN | NaN | NaN | NaN |
| LDL | 2 | Hypertension | 10 | 103.11 | 106.90 | 114.67 | 11.56 |
| LDL | 2 | No hypertension | 5 | 96.00 | 81.60 | 99.75 | 3.75 |
| LDL | 3 | Hypertension | 6 | 90.50 | 96.75 | 101.30 | 10.80 |
| LDL | 3 | No hypertension | 9 | 124.22 | 110.93 | 98.62 | -25.60 |
| LDL | 4 | Hypertension | 8 | 115.12 | 92.71 | 116.25 | 1.12 |
| LDL | 4 | No hypertension | 7 | 94.29 | 86.57 | 95.83 | 1.55 |
| HDL | 1 | Hypertension | 10 | NaN | NaN | NaN | NaN |
| HDL | 1 | No hypertension | 8 | NaN | NaN | NaN | NaN |
| HDL | 2 | Hypertension | 10 | 62.08 | 63.40 | 63.78 | 1.70 |
| HDL | 2 | No hypertension | 5 | 54.50 | 51.20 | 52.50 | -2.00 |
| HDL | 3 | Hypertension | 6 | 63.17 | 61.38 | 59.73 | -3.43 |
| HDL | 3 | No hypertension | 9 | 48.00 | 49.99 | 51.00 | 3.00 |
| HDL | 4 | Hypertension | 8 | 56.12 | 51.29 | 58.38 | 2.25 |
| HDL | 4 | No hypertension | 7 | 52.81 | 54.13 | 56.33 | 3.52 |